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Aldrin V Gomes

TitleAsst Prof
InstitutionUniversity of California Davis
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes A, Irving TC, Szczesna-Cordary D. Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. Proc Natl Acad Sci U S A. 2018 Mar 06; 115(10):E2338-E2347. PMID: 29463717.
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    2. Mishra M, Tiwari S, Gomes A. Protein purification and analysis: next generation Western blotting techniques. Expert Rev Proteomics. 2017 Nov; 14(11):1037-1053. PMID: 28974114.
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    3. Inceoglu B, Bettaieb A, Haj FG, Gomes A, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:68-78. PMID: 28847566.
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    4. Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes A, Wang Y, Burghardt TP, Szczesna-Cordary D. Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovasc Res. 2017 Aug 01; 113(10):1124-1136. PMID: 28371863.
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    5. Gilda JE, Gomes A. Proteasome dysfunction in cardiomyopathies. J Physiol. 2017 Jun 15; 595(12):4051-4071. PMID: 28181243.
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    6. Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes A, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res. 2017 05 30; 326:69-76. PMID: 28259677.
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    7. Nguyen S, Siu R, Dewey S, Cui Z, Gomes A. Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Front Physiol. 2016; 7:520. PMID: 27895589.
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    8. Carbonell T, Alva N, Sanchez-Nuño S, Dewey S, Gomes A. Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxid Med Cell Longev. 2016; 2016:9324692. PMID: 27800122.
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    9. Ghosh R, Goswami SK, Feitoza LF, Hammock B, Gomes A. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 2016 Nov 15; 223:923-935. PMID: 27589040.
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    10. Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes A. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016 05; 94:131-144. PMID: 27049794.
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    11. Gilda JE, Lai X, Witzmann FA, Gomes A. Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations. Mol Cell Proteomics. 2016 06; 15(6):1962-81. PMID: 27022107.
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    12. Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes A. The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 2016 07 01; 601:88-96. PMID: 26919894; PMCID: PMC4899223 [Available on 07/01/17].
    13. Landry M, Gomes A. Antibodies: Half of samples fail protein-blot tests. Nature. 2016 Jan 07; 529(7584):25. PMID: 26738583.
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    14. West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes A, Bodine SC, Baar K. Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15; 594(2):453-68. PMID: 26548696; PMCID: PMC4713726 [Available on 01/15/17].
    15. Gomes A, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 2015 Dec; 36(6):447-61. PMID: 26668058; PMCID: PMC4847725 [Available on 12/14/16].
    16. Gomes A, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015; 2015:849095. PMID: 26523200; PMCID: PMC4617440.
    17. Ghosh R, Alajbegovic A, Gomes A. NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev. 2015; 2015:536962. PMID: 26457127; PMCID: PMC4592725.
    18. Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes A. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015; 10(8):e0135392. PMID: 26287535.
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    19. Carbonell T, Gomes A. Dynamic regulation of the proteasome by systolic overload. J Mol Cell Cardiol. 2015 Oct; 87:1-3. PMID: 26219953.
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    20. Negroni JA, Morotti S, Lascano EC, Gomes A, Grandi E, Puglisi JL, Bers DM. ß-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. PMID: 25724724; PMCID: PMC4380575.
    21. Gilda JE, Gomes A. Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 2015; 1295:381-91. PMID: 25820735.
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    22. Ghosh R, Gilda JE, Gomes A. The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 2014 Oct; 11(5):549-60. PMID: 25059473; PMCID: PMC4791038.
    23. Jamart C, Gomes A, Dewey S, Deldicque L, Raymackers JM, Francaux M. Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord. 2014 May 22; 15:166. PMID: 24885455; PMCID: PMC4041039.
    24. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes A, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. PMID: 24525589; PMCID: PMC3947856.
    25. Narasimhan M, Hong J, Atieno N, Muthusamy VR, Davidson CJ, Abu-Rmaileh N, Richardson RS, Gomes A, Hoidal JR, Rajasekaran NS. Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells. Free Radic Biol Med. 2014 Jun; 71:402-14. PMID: 24613379; PMCID: PMC4493911.
    26. Puglisi JL, Goldspink PH, Gomes A, Utter MS, Bers DM, Solaro RJ. Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 2014 Jun 15; 552-553:50-9. PMID: 24480308; PMCID: PMC4043955.
    27. Gomes A. Genetics of proteasome diseases. Scientifica (Cairo). 2013; 2013:637629. PMID: 24490108; PMCID: PMC3892944.
    28. Cui Z, Hwang SM, Gomes A. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan; 34(1):96-109. PMID: 24164898; PMCID: PMC3911280.
    29. Cui Z, Gilda JE, Gomes A. Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 2014 Feb 01; 446:44-52. PMID: 24141075; PMCID: PMC3901411.
    30. Cui Z, Scruggs SB, Gilda JE, Ping P, Gomes A. Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 2014 Jun; 71:32-42. PMID: 24140722.
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    31. Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes A, Shelton GD, Lieber RL, Chen J. Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 2014 Jan 01; 23(1):209-25. PMID: 23975679; PMCID: PMC3916749.
    32. Dewey S, Lai X, Witzmann FA, Sohal M, Gomes A. Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy. J Proteome Res. 2013 Sep 06; 12(9):3920-33. PMID: 23848590.
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    33. Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes A, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 01; 100(1):63-73. PMID: 23761402; PMCID: PMC3778956.
    34. Gilda JE, Gomes A. Stain-Free total protein staining is a superior loading control to ß-actin for Western blots. Anal Biochem. 2013 Sep 15; 440(2):186-8. PMID: 23747530; PMCID: PMC3809032.
    35. Rajagopalan V, Zhao M, Reddy S, Fajardo G, Wang X, Dewey S, Gomes A, Bernstein D. Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H551-62. PMID: 23729213; PMCID: PMC3891246.
    36. Gilda JE, Gomes A. How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. J Mol Cell Cardiol. 2013 Sep; 62:108-10. PMID: 23732927.
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    37. Szczesna-Cordary D, Morimoto S, Gomes A, Moore JR. Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012; 2012:870942. PMID: 23304510; PMCID: PMC3529434.
    38. Iorga A, Dewey S, Partow-Navid R, Gomes A, Eghbali M. Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice. PLoS One. 2012; 7(11):e48601. PMID: 23166589; PMCID: PMC3499532.
    39. Pinto JR, Gomes A, Jones MA, Liang J, Nguyen S, Miller T, Parvatiyar MS, Potter JD. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 2012 Oct 26; 287(44):37362-70. PMID: 22977240; PMCID: PMC3481333.
    40. Gomes A, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 2012 Jul; 26(7):2986-99. PMID: 22508689; PMCID: PMC3382096.
    41. Xu Q, Cui Z, Venkatraman G, Gomes A. The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophys Rev. 2012 Jun; 4(2):125-135. PMID: 28510094.
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    42. Cui Z, Dewey S, Gomes A. Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am J Cardiovasc Dis. 2011; 1(3):274-92. PMID: 22254205; PMCID: PMC3253522.
    43. Hwee DT, Gomes A, Bodine SC. Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E967-77. PMID: 21828340; PMCID: PMC3214003.
    44. Dewey S, Xu Q, Gomes A. Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 2010 Nov; 49(5):715-8. PMID: 20705073; PMCID: PMC2949537.
    45. Divald A, Kivity S, Wang P, Hochhauser E, Roberts B, Teichberg S, Gomes A, Powell SR. Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res. 2010 Jun 25; 106(12):1829-38. PMID: 20431057.
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    46. Dewey S, Gomes A. Non-antigen processing immunoproteasomes in diabetic hearts? J Mol Cell Cardiol. 2010 Jul; 49(1):1-4. PMID: 20382154.
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    47. Xu Q, Dewey S, Nguyen S, Gomes A. Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes. J Mol Cell Cardiol. 2010 May; 48(5):899-909. PMID: 20298698.
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    48. Tikunova SB, Liu B, Swindle N, Little SC, Gomes A, Swartz DR, Davis JP. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010 Mar 09; 49(9):1975-84. PMID: 20128626; PMCID: PMC2845643.
    49. Willott RH, Gomes A, Chang AN, Parvatiyar MS, Pinto JR, Potter JD. Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function? J Mol Cell Cardiol. 2010 May; 48(5):882-92. PMID: 19914256.
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    50. Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P. Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009 Feb; 46(2):268-77. PMID: 19027023; PMCID: PMC3661410.
    51. Gomes A, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb; 8(2):302-15. PMID: 18931337; PMCID: PMC2634581.
    52. Wen Y, Pinto JR, Gomes A, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 2008 Jul 18; 283(29):20484-94. PMID: 18430738; PMCID: PMC2459290.
    53. Baldán A, Gomes A, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol. 2008 Mar 01; 180(5):3560-8. PMID: 18292583.
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    54. Drews O, Wildgruber R, Zong C, Sukop U, Nissum M, Weber G, Gomes A, Ping P. Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol Cell Proteomics. 2007 Nov; 6(11):2021-31. PMID: 17660509.
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    55. Gomes A, Zong C, Ping P. Protein degradation by the 26S proteasome system in the normal and stressed myocardium. Antioxid Redox Signal. 2006 Sep-Oct; 8(9-10):1677-91. PMID: 16987021.
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    56. Gomes A, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P. Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006 Aug 18; 99(4):362-71. PMID: 16857966.
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    57. Zong C, Gomes A, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P. Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006 Aug 18; 99(4):372-80. PMID: 16857963.
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    58. Gomes A, Harada K, Potter JD. A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin. J Mol Cell Cardiol. 2005 Nov; 39(5):754-65. PMID: 16005017.
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    59. Gomes A, Liang J, Potter JD. Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J Biol Chem. 2005 Sep 02; 280(35):30909-15. PMID: 15961398.
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    60. Gomes A, Zong C, Edmondson RD, Berhane BT, Wang GW, Le S, Young G, Zhang J, Vondriska TM, Whitelegge JP, Jones RC, Joshua IG, Thyparambil S, Pantaleon D, Qiao J, Loo J, Ping P. The murine cardiac 26S proteasome: an organelle awaiting exploration. Ann N Y Acad Sci. 2005 Jun; 1047:197-207. PMID: 16093497.
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    61. Gomes A, Venkatraman G, Potter JD. The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 2005 Jun; 1047:30-7. PMID: 16093482.
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    62. Venkatraman G, Gomes A, Kerrick WG, Potter JD. Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J Biol Chem. 2005 May 06; 280(18):17584-92. PMID: 15623536.
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    63. Gomes A, Venkatraman G, Davis JP, Tikunova SB, Engel P, Solaro RJ, Potter JD. Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem. 2004 Nov 26; 279(48):49579-87. PMID: 15358779.
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    64. Gomes A, Potter JD. Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem. 2004 08; 263(1-2):99-114. PMID: 15524171.
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    65. Gomes A, Barnes JA, Harada K, Potter JD. Role of troponin T in disease. Mol Cell Biochem. 2004 08; 263(1-2):115-29. PMID: 15524172.
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    66. Yuan T, Gomes A, Barnes JA, Hunter HN, Vogel HJ. Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch Biochem Biophys. 2004 Jan 15; 421(2):192-206. PMID: 14984199.
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    67. Venkatraman G, Harada K, Gomes A, Kerrick WG, Potter JD. Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J Biol Chem. 2003 Oct 24; 278(43):41670-6. PMID: 12923187.
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    68. Gomes A, Potter JD, Szczesna-Cordary D. The role of troponins in muscle contraction. IUBMB Life. 2002 Dec; 54(6):323-33. PMID: 12665242.
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    69. Gomes A, Guzman G, Zhao J, Potter JD. Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J Biol Chem. 2002 Sep 20; 277(38):35341-9. PMID: 12093807.
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    70. Barnes JA, Gomes A. Proteolytic signals in the primary structure of annexins. Mol Cell Biochem. 2002 Feb; 231(1-2):1-7. PMID: 11952151.
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    71. Lang R, Gomes A, Zhao J, Housmans PR, Miller T, Potter JD. Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy. J Biol Chem. 2002 Apr 05; 277(14):11670-8. PMID: 11801593.
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