Andrew Garreth Edwards

Title(s)Assistant Adjunct Professor, Pharmacology
SchoolUniversity of California, Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca2+ -handling protein variation. J Physiol. 2022 Sep 16. Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. PMID: 36114707.
      View in: PubMed   Mentions: 2     Fields:    
    2. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. J Physiol. 2022 Sep 12. Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E. PMID: 36094888.
      View in: PubMed   Mentions:    Fields:    
    3. Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications. Sci Adv. 2021 Nov 19; 7(47):eabg0927. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Pritoni M, Ripplinger CM, Bers DM, Edwards AG, Grandi E. PMID: 34788089; PMCID: PMC8598003.
      View in: PubMed   Mentions: 4     Fields:    
    4. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 08; 110(2):380-391. Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. PMID: 33772748; PMCID: PMC8316283.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 10; 177(19):4497-4515. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. PMID: 32667679; PMCID: PMC7484508.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Arrhythmogenic Current Generation by Myofilament-Triggered Ca2+ Release and Sarcomere Heterogeneity. Biophys J. 2019 12 17; 117(12):2471-2485. Timmermann V, Edwards AG, Wall ST, Sundnes J, McCulloch AD. PMID: 31810659; PMCID: PMC6990379.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    7. Properties of cardiac conduction in a cell-based computational model. PLoS Comput Biol. 2019 05; 15(5):e1007042. Jæger KH, Edwards AG, McCulloch A, Tveito A. PMID: 31150383; PMCID: PMC6561587.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    8. Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia. Circ Arrhythm Electrophysiol. 2019 04; 12(4):e007045. Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettil? V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, R?sj? H, Louch WE. PMID: 30943765.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations. Cereb Cortex. 2019 02 01; 29(2):875-891. M?ki-Marttunen T, Krull F, Bettella F, Hagen E, N?ss S, Ness TV, Moberget T, Elvs?shagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT. PMID: 30475994; PMCID: PMC6319172.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    10. Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems. Sci Rep. 2018 12 04; 8(1):17626. Tveito A, Jæger KH, Huebsch N, Charrez B, Edwards AG, Wall S, Healy KE. PMID: 30514966; PMCID: PMC6279833.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    11. 3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes. J Physiol. 2019 01; 597(2):399-418. Shen X, van den Brink J, Hou Y, Colli D, Le C, Kolstad TR, MacQuaide N, Carlson CR, Kekenes-Huskey PM, Edwards AG, Soeller C, Louch WE. PMID: 30412283; PMCID: PMC6332759.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    12. Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation. PLoS One. 2018; 13(11):e0207100. Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK. PMID: 30399185; PMCID: PMC6219810.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes. Elife. 2018 10 30; 7. Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE. PMID: 30375974; PMCID: PMC6245731.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    14. Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges. Front Physiol. 2018; 9:1221. Vagos M, van Herck IGM, Sundnes J, Arevalo HJ, Edwards AG, Koivum?ki JT. PMID: 30233399; PMCID: PMC6131668.
      View in: PubMed   Mentions: 18  
    15. 33 Calcium Signaling in Cardiomyocyte Models With Realistic Geometries. . 2018 Jan 1; 314-324. Edwards EA, Hake HJ, Michailova MA, Hoshijima HM, McCulloch MA. .
      View in: Publisher Site   Mentions:
    16. Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Transl Psychiatry. 2017 11 17; 7(11):5. M?ki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA. PMID: 30446648; PMCID: PMC5802468.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    17. An integrative appraisal of mechano-electric feedback mechanisms in the heart. Prog Biophys Mol Biol. 2017 11; 130(Pt B):404-417. Timmermann V, Dejgaard LA, Haugaa KH, Edwards AG, Sundnes J, McCulloch AD, Wall ST. PMID: 28851517; PMCID: PMC5716869.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons. Front Comput Neurosci. 2017; 11:27. Tveito A, J?ger KH, Lines GT, Paszkowski L, Sundnes J, Edwards AG, Maki-Marttunen T, Halnes G, Einevoll GT. PMID: 28484385; PMCID: PMC5401906.
      View in: PubMed   Mentions: 17  
    19. Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling. Clin Med Insights Cardiol. 2017; 11:1179546817698602. Maleckar MM, Edwards AG, Louch WE, Lines GT. PMID: 28469494; PMCID: PMC5392018.
      View in: PubMed   Mentions: 6  
    20. Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus. Clin Med Insights Cardiol. 2017; 11:1179546816686061. Edwards AG, Louch WE. PMID: 28469490; PMCID: PMC5392019.
      View in: PubMed   Mentions: 37  
    21. Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states. Math Biosci. 2016 07; 277:126-35. Tveito A, Lines GT, Edwards AG, McCulloch A. PMID: 27154008; PMCID: PMC4894014.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    22. Field-measured drag area is a key correlate of level cycling time trial performance. PeerJ. 2015; 3:e1144. Peterman JE, Lim AC, Ignatz RI, Edwards AG, Byrnes WC. PMID: 26290797; PMCID: PMC4540006.
      View in: PubMed   Mentions:
    23. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. PMID: 26241847; PMCID: PMC4734906.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    24. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291; PMCID: PMC4376416.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    25. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. J Mol Cell Cardiol. 2014 Nov; 76:265-74. Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens JH, McCulloch AD. PMID: 25257915; PMCID: PMC4250283.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    26. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. PMID: 25236710; PMCID: PMC4301603.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    27. CaMKII comes of age in cardiac health and disease. Front Pharmacol. 2014; 5:154. Grandi E, Edwards AG, Herren AW, Bers DM. PMID: 25071573; PMCID: PMC4080132.
      View in: PubMed   Mentions: 6  
    28. Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia. Front Pharmacol. 2014; 5:110. Vincent KP, McCulloch AD, Edwards AG. PMID: 24994983; PMCID: PMC4062880.
      View in: PubMed   Mentions: 10  
    29. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. J Physiol. 2014 Mar 15; 592(6):1181-97. Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. PMID: 24421356; PMCID: PMC3961080.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    30. 33 Calcium Signaling in Cardiomyocyte Models With Realistic Geometries. . 2014 Jan 1; 331-340. Michailova MA, Edwards EA, Hake HJ, Hoshijima HM, McCulloch MA. .
      View in: Publisher Site   Mentions:
    31. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opin Ther Targets. 2013 Aug; 17(8):889-903. Westenbrink BD, Edwards AG, McCulloch AD, Brown JH. PMID: 23789646; PMCID: PMC5551677.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    32. Conference report from the 2012 AHA scientific sessions in Los Angeles. Expert Opin Ther Targets. 2013 Jun; 17(6):733-7. Westenbrink BD, Edwards AG, Miyamoto S. PMID: 23642039.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    33. Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue. Prog Biophys Mol Biol. 2012 Oct-Nov; 110(2-3):295-304. Tveito A, Lines GT, Edwards AG, Maleckar MM, Michailova A, Hake J, McCulloch A. PMID: 22841534; PMCID: PMC3484180.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit. J Physiol. 2012 Sep 15; 590(18):4403-22. Hake J, Edwards AG, Yu Z, Kekenes-Huskey PM, Michailova AP, McCammon JA, Holst MJ, Hoshijima M, McCulloch AD. PMID: 22495592; PMCID: PMC3477749.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    35. Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes. Math Biosci. 2012 Apr; 236(2):97-107. Tveito A, Lines GT, Hake J, Edwards AG. PMID: 22391458; PMCID: PMC3320113.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    36. Measuring changes in aerodynamic/rolling resistances by cycle-mounted power meters. Med Sci Sports Exerc. 2011 May; 43(5):853-60. Lim AC, Homestead EP, Edwards AG, Carver TC, Kram R, Byrnes WC. PMID: 20881880.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. What for nature, and who to nurture? J Appl Physiol (1985). 2011 01; 110(1):283; discussion 294. Donato AJ, Edwards AG. PMID: 21542159.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):739-42. Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL. PMID: 20934448; PMCID: PMC3010207.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    39. Accuracy of optimized branched algorithms to assess activity-specific physical activity energy expenditure. Med Sci Sports Exerc. 2010 Apr; 42(4):672-82. Edwards AG, Hill JO, Byrnes WC, Browning RC. PMID: 19952842; PMCID: PMC2888697.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction. J Physiol. 2009 Dec 01; 587(Pt 23):5723-37. Edwards AG, Rees ML, Gioscia RA, Zachman DK, Lynch JM, Browder JC, Chicco AJ, Moore RL. PMID: 19805744; PMCID: PMC2805381.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Aerodynamic characteristics as determinants of the drafting effect in cycling. Med Sci Sports Exerc. 2007 Jan; 39(1):170-6. Edwards AG, Byrnes WC. PMID: 17218899.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans