Christopher S Fraser

InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sokabe M, Fraser C. Toward a Kinetic Understanding of Eukaryotic Translation. Cold Spring Harb Perspect Biol. 2018 Jun 29. PMID: 29959192.
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    2. Avanzino BC, Fuchs G, Fraser C. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. Proc Natl Acad Sci U S A. 2017 Sep 05; 114(36):9611-9616. PMID: 28827335.
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    3. Sokabe M, Fraser C. A helicase-independent activity of eIF4A in promoting mRNA recruitment to the human ribosome. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6304-6309. PMID: 28559306.
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    4. Barbosa NM, Boldrin PE, Rossi D, Yamamoto PA, Watanabe TF, Serrão VH, Hershey JW, Fraser C, Valentini SR, Zanelli CF. Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis. Amino Acids. 2016 10; 48(10):2363-74. PMID: 27388480.
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    5. Rossi D, Barbosa NM, Galvão FC, Boldrin PE, Hershey JW, Zanelli CF, Fraser C, Valentini SR. Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome. PLoS One. 2016; 11(4):e0154205. PMID: 27115996; PMCID: PMC4845985.
    6. García-García C, Frieda KL, Feoktistova K, Fraser C, Block SM. RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase. Science. 2015 Jun 26; 348(6242):1486-8. PMID: 26113725; PMCID: PMC4605566.
    7. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser C, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
    8. Fraser C. Quantitative studies of mRNA recruitment to the eukaryotic ribosome. Biochimie. 2015 Jul; 114:58-71. PMID: 25742741; PMCID: PMC4458453.
    9. Sokabe M, Fraser C. Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. J Biol Chem. 2014 Nov 14; 289(46):31827-36. PMID: 25246524; PMCID: PMC4231660.
    10. Avanzino BC, Fraser C. DEAD box unwinding caught in the act. Structure. 2014 Jul 08; 22(7):931-2. PMID: 25007220; PMCID: PMC4122117.
    11. Andaya A, Villa N, Jia W, Fraser C, Leary JA. Phosphorylation stoichiometries of human eukaryotic initiation factors. Int J Mol Sci. 2014 Jun 27; 15(7):11523-38. PMID: 24979134; PMCID: PMC4139797.
    12. Özes AR, Feoktistova K, Avanzino BC, Baldwin EP, Fraser C. Real-time fluorescence assays to monitor duplex unwinding and ATPase activities of helicases. Nat Protoc. 2014 Jul; 9(7):1645-61. PMID: 24945382.
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    13. Villa N, Do A, Hershey JW, Fraser C. Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. J Biol Chem. 2013 Nov 15; 288(46):32932-40. PMID: 24092755; PMCID: PMC3829144.
    14. Feoktistova K, Tuvshintogs E, Do A, Fraser C. Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13339-44. PMID: 23901100; PMCID: PMC3746923.
    15. Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser C, Nagar B. Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure. 2013 Apr 02; 21(4):517-27. PMID: 23478064; PMCID: PMC3659266.
    16. Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser C, Doudna JA, Nogales E, Cate JH. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20473-8. PMID: 22135459; PMCID: PMC3251073.
    17. Sokabe M, Fraser C, Hershey JW. The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res. 2012 Jan; 40(2):905-13. PMID: 21940399; PMCID: PMC3258154.
    18. Andaya A, Jia W, Sokabe M, Fraser C, Hershey JW, Leary JA. Phosphorylation of human eukaryotic initiation factor 2?: novel site identification and targeted PKC involvement. J Proteome Res. 2011 Oct 07; 10(10):4613-23. PMID: 21854064; PMCID: PMC3210080.
    19. Özes AR, Feoktistova K, Avanzino BC, Fraser C. Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. J Mol Biol. 2011 Sep 30; 412(4):674-87. PMID: 21840318; PMCID: PMC3175293.
    20. Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser C, Park MH. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 2011 Jan 01; 433(1):205-13. PMID: 20942800.
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    21. Park JH, Dias CA, Lee SB, Valentini SR, Sokabe M, Fraser C, Park MH. Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes. Protein Eng Des Sel. 2011 Mar; 24(3):301-9. PMID: 21131325; PMCID: PMC3038461.
    22. Fraser C. The molecular basis of translational control. Prog Mol Biol Transl Sci. 2009; 90:1-51. PMID: 20374738.
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    23. Fraser C, Hershey JW, Doudna JA. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat Struct Mol Biol. 2009 Apr; 16(4):397-404. PMID: 19287397; PMCID: PMC2689074.
    24. Zhou M, Sandercock AM, Fraser C, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18139-44. PMID: 18599441; PMCID: PMC2587604.
    25. Pöyry TA, Kaminski A, Connell EJ, Fraser C, Jackson RJ. The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 2007 Dec 01; 21(23):3149-62. PMID: 18056426; PMCID: PMC2081980.
    26. Fraser C, Berry KE, Hershey JW, Doudna JA. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell. 2007 Jun 22; 26(6):811-9. PMID: 17588516.
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    27. Fraser C, Doudna JA. Quantitative studies of ribosome conformational dynamics. Q Rev Biophys. 2007 May; 40(2):163-89. PMID: 18072984.
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    28. Damoc E, Fraser C, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics. 2007 Jul; 6(7):1135-46. PMID: 17322308.
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    29. Fraser C, Doudna JA. Structural and mechanistic insights into hepatitis C viral translation initiation. Nat Rev Microbiol. 2007 Jan; 5(1):29-38. PMID: 17128284.
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    30. Siridechadilok B, Fraser C, Hall RJ, Doudna JA, Nogales E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science. 2005 Dec 02; 310(5753):1513-5. PMID: 16322461.
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    31. Fraser C, Hershey JW. Movement in ribosome translocation. J Biol. 2005; 4(2):8. PMID: 15985151; PMCID: PMC1175999.
    32. Ji H, Fraser C, Yu Y, Leary J, Doudna JA. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):16990-5. PMID: 15563596; PMCID: PMC534415.
    33. Fraser C, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem. 2004 Mar 05; 279(10):8946-56. PMID: 14688252.
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    34. Mayeur GL, Fraser C, Peiretti F, Block KL, Hershey JW. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. Eur J Biochem. 2003 Oct; 270(20):4133-9. PMID: 14519125.
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