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Colleen E Clancy

TitleAssoc Prof
InstitutionUniversity of California Davis
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Agarwal SR, Gratwohl J, Cozad M, Yang PC, Clancy C, Harvey RD. Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes. Front Pharmacol. 2018; 9:332. PMID: 29740315.
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    2. Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy C, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Front Physiol. 2018; 9:207. PMID: 29706893.
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    3. Vorobyov I, Clancy C. Sex, drugs, and funky rhythms. Heart Rhythm. 2018 Apr; 15(4):485-486. PMID: 29605014.
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    4. DeMarco KR, Bekker S, Clancy C, Noskov SY, Vorobyov I. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Front Pharmacol. 2018; 9:26. PMID: 29449809.
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    5. Sato D, Clancy C, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep; 3(9):e00388. PMID: 28924617.
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    6. Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy C. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. J Physiol. 2017 Jul 15; 595(14):4695-4723. PMID: 28516454.
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    7. Chiamvimonvat N, Chen-Izu Y, Clancy C, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 01; 595(7):2229-2252. PMID: 27808412.
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    8. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy C. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. PMID: 27800622.
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    9. Kurokawa J, Kodama M, Clancy C, Furukawa T. Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes. Pharmacol Ther. 2016 Dec; 168:23-28. PMID: 27595633.
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    10. Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy C. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. J Mol Cell Cardiol. 2016 Oct; 99:151-161. PMID: 27545042.
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    11. Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy C. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. PLoS Comput Biol. 2016 Jul; 12(7):e1005005. PMID: 27409243; PMCID: PMC4943723.
    12. Gray B, Bagnall RD, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang PC, Clancy C, Sy RW, Semsarian C. A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2016 08; 13(8):1652-60. PMID: 27157848.
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    13. Zhang Y, Barocas VH, Berceli SA, Clancy C, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Ann Biomed Eng. 2016 09; 44(9):2642-60. PMID: 27138523.
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    14. Moreno JD, Lewis TJ, Clancy C. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. PLoS One. 2016; 11(3):e0150761. PMID: 26963710.
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    15. Clancy C, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. Multiscale Modeling in the Clinic: Drug Design and Development. Ann Biomed Eng. 2016 09; 44(9):2591-610. PMID: 26885640.
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    16. Agarwal SR, Clancy C, Harvey RD. Mechanisms Restricting Diffusion of Intracellular cAMP. Sci Rep. 2016 Jan 22; 6:19577. PMID: 26795432; PMCID: PMC4726171.
    17. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy C. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697; PMCID: PMC4784170.
    18. Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy C, Zhang XD, Chiamvimonvat N, Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016 Jan 29; 291(5):2499-509. PMID: 26515070; PMCID: PMC4732230 [Available on 01/29/17].
    19. Romero L, Trenor B, Yang PC, Saiz J, Clancy C. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2015 Oct; 87:271-82. PMID: 26859003; PMCID: PMC4935925.
    20. Perissinotti LL, Guo J, De Biase PM, Clancy C, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophys J. 2015 Mar 24; 108(6):1414-1424. PMID: 25809254.
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    21. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy C, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
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    22. Clancy C, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289; PMCID: PMC4376414.
    23. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy C, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291; PMCID: PMC4376416.
    24. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy C. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. J Physiol. 2015 Mar 15; 593(6):1429-42. PMID: 25545172; PMCID: PMC4376422.
    25. Yarov-Yarovoy V, Allen TW, Clancy C. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discov Today Dis Models. 2014; 14:3-10. PMID: 26635886.
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    26. Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy C, Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling. PLoS One. 2014; 9(4):e95835. PMID: 24752595; PMCID: PMC3994114.
    27. Romero L, Trenor B, Yang PC, Saiz J, Clancy C. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2014 Jul; 72:126-37. PMID: 24631769; PMCID: PMC4066959.
    28. Clancy C, Xiang YK. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. PMID: 24598634.
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    29. Sato D, Clancy C. Cardiac electrophysiological dynamics from the cellular level to the organ level. Biomed Eng Comput Biol. 2013; 5:69-75. PMID: 25288904; PMCID: PMC4147771.
    30. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy C. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. PMID: 23897695; PMCID: PMC3896218.
    31. Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy C, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. J Cardiovasc Electrophysiol. 2013 Sep; 24(9):1021-7. PMID: 23631727; PMCID: PMC4059362.
    32. Lewin N, Aksay E, Clancy C. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One. 2012; 7(10):e47250. PMID: 23071770; PMCID: PMC3470566.
    33. Yang PC, Clancy C. In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Front Physiol. 2012; 3:360. PMID: 23049511; PMCID: PMC3442371.
    34. Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy C. Computational approaches to understand cardiac electrophysiology and arrhythmias. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H766-83. PMID: 22886409; PMCID: PMC3774200.
    35. Kurokawa J, Kodama M, Furukawa T, Clancy C. Sex and gender aspects in antiarrhythmic therapy. Handb Exp Pharmacol. 2012; (214):237-63. PMID: 23027454.
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    36. Moreno JD, Clancy C. Pathophysiology of the cardiac late Na current and its potential as a drug target. J Mol Cell Cardiol. 2012 Mar; 52(3):608-19. PMID: 22198344; PMCID: PMC3816394.
    37. Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy C. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 2011 Aug 31; 3(98):98ra83. PMID: 21885405; PMCID: PMC3328405.
    38. Yang PC, Clancy C. Gender-based differences in cardiac diseases. J Biomed Res. 2011 Mar; 25(2):81-9. PMID: 23554675; PMCID: PMC3596698.
    39. Oren RV, Clancy C. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput Biol. 2010 Dec 23; 6(12):e1001041. PMID: 21203483; PMCID: PMC3009599.
    40. Yang PC, Clancy C. Effects of sex hormones on cardiac repolarization. J Cardiovasc Pharmacol. 2010 Aug; 56(2):123-9. PMID: 20164789.
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    41. Yang PC, Kurokawa J, Furukawa T, Clancy C. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput Biol. 2010 Jan 29; 6(1):e1000658. PMID: 20126530; PMCID: PMC2813260.
    42. Protas L, Oren RV, Clancy C, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. J Mol Cell Cardiol. 2010 Jan; 48(1):172-80. PMID: 19665465; PMCID: PMC2813407.
    43. Ahrens-Nicklas RC, Clancy C, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovasc Res. 2009 Jun 01; 82(3):439-47. PMID: 19264765; PMCID: PMC2682617.
    44. Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy C, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. J Physiol. 2009 Apr 01; 587(Pt 7):1513-25. PMID: 19171659; PMCID: PMC2678222.
    45. Akar FG, Clancy C. Arrhythmia models: in vivo, in vitro and in silico. Drug Discov Today Dis Models. 2009; 6(3):55-56. PMID: 21072326.
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    46. Moreno JD, Clancy C. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discov Today Dis Models. 2009; 6(3):71-84. PMID: 20652086.
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    47. Furukawa T, Kurokawa J, Clancy C. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Curr Cardiol Rev. 2008 Nov; 4(4):244-50. PMID: 20066131; PMCID: PMC2801855.
    48. Rudy Y, Ackerman MJ, Bers DM, Clancy C, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 2008 Sep 09; 118(11):1202-11. PMID: 18779456; PMCID: PMC2908516.
    49. Xu J, Clancy C. Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS One. 2008 Apr 30; 3(4):e2056. PMID: 18446231; PMCID: PMC2323611.
    50. Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy C, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 2007 Dec 18; 116(25):2913-22. PMID: 18056530.
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    51. Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy C, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13; 116(20):2325-45. PMID: 17998470.
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    52. Zhu ZI, Clancy C. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S47-50. PMID: 17993328.
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    53. Zhu ZI, Clancy C. L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3480-9. PMID: 17933974.
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    54. Clancy C, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52. PMID: 17761312.
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    55. Clancy C, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H66-75. PMID: 16997895; PMCID: PMC2034498.
    56. Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy C, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet. 2006 Oct 01; 15(19):2888-902. PMID: 16923798.
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    57. Zhu ZI, Clancy C. From mutation to clinical presentation: mechanisms in the black box. J Mol Cell Cardiol. 2005 Jun; 38(6):965-8. PMID: 15878172.
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    58. Terrenoire C, Clancy C, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res. 2005 Mar 18; 96(5):e25-34. PMID: 15731462.
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    59. Clancy C, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiol Rev. 2005 Jan; 85(1):33-47. PMID: 15618477.
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    60. Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy C, Escande D, Charpentier F. Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovasc Res. 2005 Jan 01; 65(1):128-37. PMID: 15621040.
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    61. Clancy C, Kass RS. Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J. 2004 Apr; 86(4):2606-14. PMID: 15041696; PMCID: PMC1304107.
    62. Glaaser IW, Kass RS, Clancy C. Mechanisms of genetic arrhythmias: from DNA to ECG. Prog Cardiovasc Dis. 2003 Nov-Dec; 46(3):259-70. PMID: 14685943.
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    63. Clancy C, Kass RS. Pharmacogenomics in the treatment of epilepsy. Pharmacogenomics. 2003 Nov; 4(6):747-51. PMID: 14596638.
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    64. Tateyama M, Rivolta I, Clancy C, Kass RS. Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. J Biol Chem. 2003 Nov 21; 278(47):46718-26. PMID: 14500710.
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    65. Clancy C, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. PMID: 12695286.
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    66. Liu H, Clancy C, Cormier J, Kass R. Mutations in cardiac sodium channels: clinical implications. Am J Pharmacogenomics. 2003; 3(3):173-9. PMID: 12814325.
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    67. Clancy C, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest. 2002 Nov; 110(9):1251-62. PMID: 12417563; PMCID: PMC151612.
    68. Clancy C, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. J Clin Invest. 2002 Oct; 110(8):1075-7. PMID: 12393842; PMCID: PMC150807.
    69. Rivolta I, Clancy C, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiol Genomics. 2002 Sep 03; 10(3):191-7. PMID: 12209021.
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    70. Splawski I, Timothy KW, Tateyama M, Clancy C, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002 Aug 23; 297(5585):1333-6. PMID: 12193783.
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    71. Liu H, Tateyama M, Clancy C, Abriel H, Kass RS. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. J Gen Physiol. 2002 Jul; 120(1):39-51. PMID: 12084774; PMCID: PMC2311398.
    72. Clancy C, Rudy Y. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 2002 Mar 12; 105(10):1208-13. PMID: 11889015; PMCID: PMC1997279.
    73. Clancy C, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. PMID: 12540747.
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