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Donald M Bers

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers D, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13):E3036-E3044. PMID: 29531045.
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    2. Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers D, Auwerx J, Nunnari J. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife. 2018 Feb 22; 7. PMID: 29469807.
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    3. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers D. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and ß-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 Feb; 11(2):e005852. PMID: 29437761.
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    4. Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers D, Anderson ME, Song LS, Fill M, Ai X. Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis. Circ Res. 2018 Mar 16; 122(6):821-835. PMID: 29352041.
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    5. Liu M, Hoskins A, Verma N, Bers D, Despa S, Despa F. Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium. Biochim Biophys Acta. 2018 May; 1864(5 Pt B):1923-1930. PMID: 29066284.
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    6. Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers D. Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart. Circ Res. 2017 Dec 08; 121(12):1379-1391. PMID: 28970285.
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    7. Sato D, Clancy CE, Bers D. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep; 3(9):e00388. PMID: 28924617.
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    8. da Silva RR, Goroso DG, Bers D, Puglisi JL. MarkoLAB: A simulator to study ionic channel's stochastic behavior. Comput Biol Med. 2017 Aug 01; 87:258-270. PMID: 28618338.
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    9. Yuen GK, Galice S, Bers D. Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes. J Mol Cell Cardiol. 2017 Jul; 108:158-169. PMID: 28587810.
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    10. Pereira L, Bare DJ, Galice S, Shannon TR, Bers D. ß-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway. J Mol Cell Cardiol. 2017 Jul; 108:8-16. PMID: 28476660.
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    11. Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers D, Pantano S, Zaccolo M. FRET biosensor uncovers cAMP nano-domains at ß-adrenergic targets that dictate precise tuning of cardiac contractility. Nat Commun. 2017 Apr 20; 8:15031. PMID: 28425435.
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    12. Bers D, Chen-Izu Y. K+ channels and cardiac electrophysiology. J Physiol. 2017 Apr 01; 595(7):2205-2207. PMID: 28370016.
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    13. Bartos DC, Morotti S, Ginsburg KS, Grandi E, Bers D. Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes. J Physiol. 2017 Apr 01; 595(7):2253-2268. PMID: 28008618.
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    14. Kennedy M, Bers D, Chiamvimonvat N, Sato D. Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans. J Physiol. 2017 Apr 01; 595(7):2285-2297. PMID: 27902841.
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    15. De Jesus NM, Wang L, Lai J, Rigor RR, Francis Stuart SD, Bers D, Lindsey ML, Ripplinger CM. Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction. Heart Rhythm. 2017 05; 14(5):727-736. PMID: 28111350.
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    16. Bers D. CALMing Down Arrhythmogenic Calmodulinopathies via a Precision Medicine Approach. Circ Res. 2017 Jan 06; 120(1):3-4. PMID: 28057778.
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    17. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers D, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 01; 595(7):2229-2252. PMID: 27808412.
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    18. Grandi E, Sanguinetti MC, Bartos DC, Bers D, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 Apr 01; 595(7):2209-2228. PMID: 27861921.
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    19. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers D, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016 Nov 08; 68(19):2086-2096. PMID: 27810048.
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    20. Himes RD, Smolin N, Kukol A, Bossuyt J, Bers D, Robia SL. L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes. Biochemistry. 2016 Nov 08; 55(44):6196-6204. PMID: 27718550.
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    21. Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers D, Cornea RL. High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels. SLAS Discov. 2017 Feb; 22(2):176-186. PMID: 27760856.
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    22. Bers D. Stabilizing ryanodine receptor gating quiets arrhythmogenic events in human heart failure and atrial fibrillation. Heart Rhythm. 2017 03; 14(3):420-421. PMID: 27725286.
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    23. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. PMID: 27576469.
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    24. Galice S, Bers D, Sato D. Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction. Biophys J. 2016 Jun 21; 110(12):2671-2677. PMID: 27332125; PMCID: PMC4919541 [Available on 06/21/17].
    25. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers D. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036.
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    26. Rebbeck RT, Nitu FR, Rohde D, Most P, Bers D, Thomas DD, Cornea RL. S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex. J Biol Chem. 2016 07 22; 291(30):15896-907. PMID: 27226555; PMCID: PMC4957069 [Available on 07/22/17].
    27. Hoeker GS, Hanafy MA, Oster RA, Bers D, Pogwizd SM. Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits. J Cardiovasc Pharmacol. 2016 Mar; 67(3):260-5. PMID: 26650851; PMCID: PMC4783262 [Available on 03/01/17].
    28. Sato D, Shannon TR, Bers D. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophys J. 2016 Jan 19; 110(2):382-390. PMID: 26789761.
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    29. Lu X, Kwong JQ, Molkentin JD, Bers D. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circ Res. 2016 Mar 04; 118(5):834-41. PMID: 26712344; PMCID: PMC4779382 [Available on 03/04/17].
    30. Bers D. Adrenergic Fight-or-Flight: S-NO Falls on PKA Targets. Circ Res. 2015 Oct 09; 117(9):747-9. PMID: 26450885; PMCID: PMC4608250 [Available on 10/09/16].
    31. Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers D. Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1472-80. PMID: 26407967.
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    32. Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers D, Sussman MA, Poizat C. Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J Biol Chem. 2015 Oct 16; 290(42):25411-26. PMID: 26324717; PMCID: PMC4646189 [Available on 10/16/16].
    33. Erickson JR, Nichols CB, Uchinoumi H, Stein ML, Bossuyt J, Bers D. S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II d. J Biol Chem. 2015 Oct 16; 290(42):25646-56. PMID: 26316536; PMCID: PMC4646208 [Available on 10/16/16].
    34. Morotti S, McCulloch AD, Bers D, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 07; 96:63-71. PMID: 26241847.
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    35. Ping P, Gustafsson ÅB, Bers D, Blatter LA, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyk J, Weiss JN, Wong R, Schwartz Longacre L. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 2015 Jul 17; 117(3):234-8. PMID: 26185209; PMCID: PMC4535701.
    36. Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers D, Molkentin JD. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Rep. 2015 Jul 07; 12(1):15-22. PMID: 26119742; PMCID: PMC4497842.
    37. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers D, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. PMID: 26095046; PMCID: PMC4546705.
    38. Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers D. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. J Mol Cell Cardiol. 2015 Aug; 85:240-8. PMID: 26092277; PMCID: PMC4530019.
    39. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers D, Brown JH. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362.
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    40. Wagner S, Maier LS, Bers D. Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death. Circ Res. 2015 Jun 05; 116(12):1956-70. PMID: 26044250; PMCID: PMC4458704.
    41. Herren AW, Weber DM, Rigor RR, Margulies KB, Phinney BS, Bers D. CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. J Proteome Res. 2015 May 01; 14(5):2298-311. PMID: 25815641.
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    42. Hammer KP, Ljubojevic S, Ripplinger CM, Pieske BM, Bers D. Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Jul; 84:1-9. PMID: 25828762; PMCID: PMC4500534.
    43. Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers D. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):3991-6. PMID: 25829540; PMCID: PMC4386405.
    44. Clancy CE, Chen-Izu Y, Bers D, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289; PMCID: PMC4376414.
    45. Shattock MJ, Ottolia M, Bers D, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291; PMCID: PMC4376416.
    46. Bers D, Chen-Izu Y. Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia. J Physiol. 2015 Mar 15; 593(6):1327-9. PMID: 25772288; PMCID: PMC4376413.
    47. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers D. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
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    48. Mattiazzi A, Bassani RA, Escobar AL, Palomeque J, Valverde CA, Vila Petroff M, Bers D. Chasing cardiac physiology and pathology down the CaMKII cascade. Am J Physiol Heart Circ Physiol. 2015 May 15; 308(10):H1177-91. PMID: 25747749; PMCID: PMC4436987.
    49. Ljubojevic S, Bers D. Nuclear calcium in cardiac myocytes. J Cardiovasc Pharmacol. 2015 Mar; 65(3):211-7. PMID: 25329749; PMCID: PMC4355307.
    50. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers D. ß-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. PMID: 25724724; PMCID: PMC4380575.
    51. Tardiff JC, Carrier L, Bers D, Poggesi C, Ferrantini C, Coppini R, Maier LS, Ashrafian H, Huke S, van der Velden J. Targets for therapy in sarcomeric cardiomyopathies. Cardiovasc Res. 2015 Apr 01; 105(4):457-70. PMID: 25634554; PMCID: PMC4402369.
    52. Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers D, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1880-5. PMID: 25583515; PMCID: PMC4330748.
    53. Ljubojevic S, Bers D. Measuring intranuclear and nuclear envelope [Ca(2+)] vs. cytosolic [Ca (2+)]. Methods Mol Biol. 2015; 1234:135-47. PMID: 25304354.
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    54. Bossuyt J, Bers D. Assessing GPCR and G protein signaling to the nucleus in live cells using fluorescent biosensors. Methods Mol Biol. 2015; 1234:149-59. PMID: 25304355.
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    55. Awad S, Al-Haffar KM, Marashly Q, Quijada P, Kunhi M, Al-Yacoub N, Wade FS, Mohammed SF, Al-Dayel F, Sutherland G, Assiri A, Sussman M, Bers D, Al-Habeeb W, Poizat C. Control of histone H3 phosphorylation by CaMKIId in response to haemodynamic cardiac stress. J Pathol. 2015 Mar; 235(4):606-18. PMID: 25421395; PMCID: PMC4383650.
    56. Svensson B, Oda T, Nitu FR, Yang Y, Cornea I, Chen-Izu Y, Fessenden JD, Bers D, Thomas DD, Cornea RL. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophys J. 2014 Nov 04; 107(9):2037-48. PMID: 25418089; PMCID: PMC4223179.
    57. De Jesus NM, Wang L, Herren AW, Wang J, Shenasa F, Bers D, Lindsey ML, Ripplinger CM. Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation. Heart Rhythm. 2015 Jan; 12(1):169-78. PMID: 25304682; PMCID: PMC4277908.
    58. Myles RC, Wang L, Bers D, Ripplinger CM. Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. J Physiol. 2015 Mar 15; 593(6):1479-93. PMID: 25772297; PMCID: PMC4376425.
    59. Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers D, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1205-13. PMID: 25236710; PMCID: PMC4301603.
    60. Sato D, Bartos DC, Ginsburg KS, Bers D. Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue. Biophys J. 2014 Sep 16; 107(6):1313-7. PMID: 25229139; PMCID: PMC4167289.
    61. Horvath B, Bers D. The late sodium current in heart failure: pathophysiology and clinical relevance. ESC Heart Fail. 2014 Sep; 1(1):26-40. PMID: 28834665.
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    62. Grandi E, Edwards AG, Herren AW, Bers D. CaMKII comes of age in cardiac health and disease. Front Pharmacol. 2014; 5:154. PMID: 25071573; PMCID: PMC4080132.
    63. Bers D, Morotti S. Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences. Front Pharmacol. 2014; 5:144. PMID: 24987371; PMCID: PMC4060732.
    64. Ljubojevic S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, Winkler C, Pritz E, Mittler T, Schmidt A, Sereinigg M, Wakula P, Zissimopoulos S, Bisping E, Post H, Marsche G, Bossuyt J, Bers D, Kockskämper J, Pieske B. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 2014 Jul 15; 130(3):244-55. PMID: 24928680; PMCID: PMC4101040.
    65. Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers D. Junctional cleft [Ca²?]i measurements using novel cleft-targeted Ca²? sensors. Circ Res. 2014 Jul 18; 115(3):339-47. PMID: 24871564; PMCID: PMC4132890.
    66. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers D, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. PMID: 24643800; PMCID: PMC4103414.
    67. Xie Y, Izu LT, Bers D, Sato D. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys J. 2014 Mar 18; 106(6):1391-7. PMID: 24655514; PMCID: PMC3984988.
    68. Xie Y, Grandi E, Bers D, Sato D. How does ß-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace. 2014 Mar; 16(3):452-7. PMID: 24569900; PMCID: PMC3934848.
    69. Wang L, Myles RC, De Jesus NM, Ohlendorf AK, Bers D, Ripplinger CM. Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circ Res. 2014 Apr 25; 114(9):1410-21. PMID: 24568740; PMCID: PMC4000583.
    70. Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL, Cornea RL, Bers D, Knollmann BC. Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res. 2014 Mar 28; 114(7):1114-24. PMID: 24563457; PMCID: PMC3990285.
    71. Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers D, Mohler PJ, Ziolo MT, Shannon TR. Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation. PLoS One. 2014; 9(2):e87495. PMID: 24498331; PMCID: PMC3911966.
    72. Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers D, Solaro RJ. Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 2014 Jun 15; 552-553:50-9. PMID: 24480308; PMCID: PMC4043955.
    73. Sato D, Bers D, Shiferaw Y. Formation of spatially discordant alternans due to fluctuations and diffusion of calcium. PLoS One. 2013; 8(12):e85365. PMID: 24392005; PMCID: PMC3877395.
    74. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers D, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672; PMCID: PMC3954117.
    75. Zhang DM, Chai Y, Erickson JR, Brown JH, Bers D, Lin YF. Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 2014 Mar 01; 592(5):971-90. PMID: 24277866; PMCID: PMC3948558.
    76. Bers D. Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction. Annu Rev Physiol. 2014; 76:107-27. PMID: 24245942.
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    77. Correll RN, Eder P, Burr AR, Despa S, Davis J, Bers D, Molkentin JD. Overexpression of the Na+/K+ ATPase a2 but not a1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res. 2014 Jan 17; 114(2):249-256. PMID: 24218169; PMCID: PMC4001807.
    78. Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers D. Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res. 2014 Jan 17; 114(2):295-306. PMID: 24186966; PMCID: PMC4004530.
    79. Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers D. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 2013 Oct 17; 502(7471):372-6. PMID: 24077098; PMCID: PMC3801227.
    80. Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers D, Wu JC. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013 Sep 10; 128(11 Suppl 1):S3-13. PMID: 24030418; PMCID: PMC3855862.
    81. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers D, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. PMID: 23897695; PMCID: PMC3896218.
    82. Awad S, Kunhi M, Little GH, Bai Y, An W, Bers D, Kedes L, Poizat C. Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. Nucleic Acids Res. 2013 Sep; 41(16):7656-72. PMID: 23804765; PMCID: PMC3763528.
    83. Bossuyt J, Bers D. Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling. J Mol Med (Berl). 2013 Aug; 91(8):907-16. PMID: 23775230; PMCID: PMC3962229.
    84. Herren AW, Bers D, Grandi E. Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H431-45. PMID: 23771687; PMCID: PMC3891248.
    85. Pavlovic D, Hall AR, Kennington EJ, Aughton K, Boguslavskyi A, Fuller W, Despa S, Bers D, Shattock MJ. Nitric oxide regulates cardiac intracellular Na? and Ca²? by modulating Na/K ATPase via PKCe and phospholemman-dependent mechanism. J Mol Cell Cardiol. 2013 Aug; 61:164-71. PMID: 23612119; PMCID: PMC3981027.
    86. Despa S, Bers D. Na? transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol. 2013 Aug; 61:2-10. PMID: 23608603; PMCID: PMC3720717.
    87. Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers D, Kranias EG, Cho C, Kim DH. Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Res Cardiol. 2013 May; 108(3):344. PMID: 23553082; PMCID: PMC4000265.
    88. Thomas RC, Bers D. Calcium-sensitive mini- and microelectrodes. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):305-9. PMID: 23547145.
      View in: PubMed
    89. Thomas RC, Bers D. How to make calcium-sensitive minielectrodes. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):370-3. PMID: 23547153.
      View in: PubMed
    90. Thomas RC, Bers D. How to make calcium-sensitive microelectrodes. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):374-8. PMID: 23547154.
      View in: PubMed
    91. Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers D, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation. 2013 Apr 23; 127(16):1677-91. PMID: 23519760; PMCID: PMC3870148.
    92. Lederer WJ, Bers D, Eisner DA. Calcium signaling in heart: multiscale, diverse, rapid, local, and remarkable. J Mol Cell Cardiol. 2013 May; 58:3-4. PMID: 23500389.
      View in: PubMed
    93. Neef S, Sag CM, Daut M, Bäumer H, Grefe C, El-Armouche A, DeSantiago J, Pereira L, Bers D, Backs J, Maier LS. While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIId-KO mice. J Mol Cell Cardiol. 2013 Jun; 59:107-16. PMID: 23473775; PMCID: PMC3738196.
    94. Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers D, Koch WJ. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One. 2013; 8(3):e57324. PMID: 23472081; PMCID: PMC3589474.
    95. Puglisi JL, Negroni JA, Chen-Izu Y, Bers D. The force-frequency relationship: insights from mathematical modeling. Adv Physiol Educ. 2013 Mar; 37(1):28-34. PMID: 23471245; PMCID: PMC3776472.
    96. Xie Y, Grandi E, Puglisi JL, Sato D, Bers D. ß-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61. PMID: 23481579; PMCID: PMC3628092.
    97. Ginsburg KS, Weber CR, Bers D. Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes. J Physiol. 2013 Apr 15; 591(8):2067-86. PMID: 23401616; PMCID: PMC3634520.
    98. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers D. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625; PMCID: PMC3690126.
    99. Bers D. Membrane receptor neighborhoods: snuggling up to the nucleus. Circ Res. 2013 Jan 18; 112(2):224-6. PMID: 23329788; PMCID: PMC3566243.
    100. Bers D, Shannon TR. Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes. J Mol Cell Cardiol. 2013 May; 58:59-66. PMID: 23321551; PMCID: PMC3628081.
    101. Lan F, Lee AS, Liang P, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers D, Robbins RC, Longaker MT, Wu JC. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell. 2013 Jan 03; 12(1):101-13. PMID: 23290139; PMCID: PMC3638033.
    102. Zhu Y, Ai X, Oster RA, Bers D, Pogwizd SM. Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits. Pflugers Arch. 2013 Jun; 465(6):805-18. PMID: 23242028; PMCID: PMC3634873.
    103. Lu X, Ginsburg KS, Kettlewell S, Bossuyt J, Smith GL, Bers D. Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release. Circ Res. 2013 Feb 01; 112(3):424-31. PMID: 23243207; PMCID: PMC3566246.
    104. Oda T, Yang Y, Nitu FR, Svensson B, Lu X, Fruen BR, Cornea RL, Bers D. In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Circ Res. 2013 Feb 01; 112(3):487-97. PMID: 23233753; PMCID: PMC3573756.
    105. Jin BE, Wulff H, Widdicombe JH, Zheng J, Bers D, Puglisi JL. A simple device to illustrate the Einthoven triangle. Adv Physiol Educ. 2012 Dec; 36(4):319-24. PMID: 23209014; PMCID: PMC3776430.
    106. Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers D. Na?/K?-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20756-61. PMID: 23185013; PMCID: PMC3528502.
    107. Chang CW, Lee L, Yu D, Dao K, Bossuyt J, Bers D. Acute ß-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation. J Biol Chem. 2013 Jan 04; 288(1):192-204. PMID: 23161540; PMCID: PMC3537013.
    108. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers D, Votruba M, Knowlton AA. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. PMID: 23316298; PMCID: PMC3541627.
    109. Bers D, Herren AW. Na(+) channel I-II loop mediates parallel genetic and phosphorylation-dependent gating changes. Circulation. 2012 Oct 23; 126(17):2042-6. PMID: 23091083; PMCID: PMC3502635.
    110. Despa S, Lingrel JB, Bers D. Na(+)/K)+)-ATPase a2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res. 2012 Sep 01; 95(4):480-6. PMID: 22739122; PMCID: PMC3422081.
    111. Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers D. CaMKIIdC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks. Biophys J. 2012 Jun 06; 102(11):2461-70. PMID: 22713561; PMCID: PMC3368151.
    112. Morotti S, Grandi E, Summa A, Ginsburg KS, Bers D. Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations. J Physiol. 2012 Sep 15; 590(18):4465-81. PMID: 22586219; PMCID: PMC3477752.
    113. Myles RC, Wang L, Kang C, Bers D, Ripplinger CM. Local ß-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res. 2012 May 25; 110(11):1454-64. PMID: 22539768; PMCID: PMC3396564.
    114. Sato D, Despa S, Bers D. Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes? Biophys J. 2012 Apr 18; 102(8):L31-3. PMID: 22768959; PMCID: PMC3328690.
    115. Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers D, Hudmon A. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem. 2012 Jun 08; 287(24):19856-69. PMID: 22514276; PMCID: PMC3370170.
    116. Bers D. Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res. 2012 Mar 16; 110(6):796-9. PMID: 22427320.
      View in: PubMed
    117. Camors E, Mohler PJ, Bers D, Despa S. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. J Mol Cell Cardiol. 2012 Jun; 52(6):1240-8. PMID: 22406428; PMCID: PMC3348355.
    118. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers D, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. PMID: 22275486; PMCID: PMC3303627.
    119. Ripplinger CM, Bers D. Human biological pacemakers: intrinsic variability and stability. Circulation. 2012 Feb 21; 125(7):856-8. PMID: 22261197.
      View in: PubMed
    120. Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers D, Molkentin JD. Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice. J Clin Invest. 2012 Jan; 122(1):280-90. PMID: 22133878; PMCID: PMC3248289.
    121. Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers D, Kranias EG. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. J Mol Cell Cardiol. 2012 Mar; 52(3):773-82. PMID: 22155237; PMCID: PMC3376549.
    122. Sato D, Bers D. How does stochastic ryanodine receptor-mediated Ca leak fail to initiate a Ca spark? Biophys J. 2011 Nov 16; 101(10):2370-9. PMID: 22098735; PMCID: PMC3218344.
    123. Guo T, Fruen BR, Nitu FR, Nguyen TD, Yang Y, Cornea RL, Bers D. FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. Biophys J. 2011 Nov 02; 101(9):2170-7. PMID: 22067155; PMCID: PMC3207159.
    124. Pereira L, Ruiz-Hurtado G, Morel E, Laurent AC, Métrich M, Domínguez-Rodríguez A, Lauton-Santos S, Lucas A, Benitah JP, Bers D, Lezoualc'h F, Gómez AM. Epac enhances excitation-transcription coupling in cardiac myocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):283-91. PMID: 22056318; PMCID: PMC3246099.
    125. Mishra S, Gray CB, Miyamoto S, Bers D, Brown JH. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011 Dec 09; 109(12):1354-62. PMID: 21998325; PMCID: PMC3241507.
    126. Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers D. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14; 109(9):1055-66. PMID: 21921263; PMCID: PMC3208665.
    127. Erickson JR, Patel R, Ferguson A, Bossuyt J, Bers D. Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res. 2011 Sep 16; 109(7):729-38. PMID: 21835909; PMCID: PMC3182829.
    128. Bossuyt J, Chang CW, Helmstadter K, Kunkel MT, Newton AC, Campbell KS, Martin JL, Bossuyt S, Robia SL, Bers D. Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin. J Biol Chem. 2011 Sep 23; 286(38):33390-400. PMID: 21795686; PMCID: PMC3190922.
    129. Bers D, Grandi E. Human atrial fibrillation: insights from computational electrophysiological models. Trends Cardiovasc Med. 2011 Jul; 21(5):145-50. PMID: 22732550; PMCID: PMC3384487.
    130. Saucerman JJ, Bers D. Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes. J Mol Cell Cardiol. 2012 Feb; 52(2):312-6. PMID: 21708171; PMCID: PMC3235247.
    131. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers D, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. PMID: 21597010; PMCID: PMC3132348.
    132. Bers D, Harris SP. Translational medicine: to the rescue of the failing heart. Nature. 2011 May 05; 473(7345):36-9. PMID: 21544138.
      View in: PubMed
    133. Wu L, Ma J, Li H, Wang C, Grandi E, Zhang P, Luo A, Bers D, Shryock JC, Belardinelli L. Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation. 2011 Apr 26; 123(16):1713-20. PMID: 21482963; PMCID: PMC4028960.
    134. Bers D. Calmodulin and S100A1 fine tune skeletal muscle E-C coupling. Focus on "Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1". Am J Physiol Cell Physiol. 2011 May; 300(5):C974-5. PMID: 21346150.
      View in: PubMed
    135. Picht E, Zima AV, Shannon TR, Duncan AM, Blatter LA, Bers D. Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release. Circ Res. 2011 Apr 01; 108(7):847-56. PMID: 21311044; PMCID: PMC3084972.
    136. Anderson ME, Brown JH, Bers D. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct; 51(4):468-73. PMID: 21276796; PMCID: PMC3158288.
    137. Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Anderson ME, Grandi E, Bers D, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-activated Ca/calmodulin kinase IId is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011 Mar 04; 108(5):555-65. PMID: 21252154; PMCID: PMC3065330.
    138. Bers D. Ca²?-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling. Heart Rhythm. 2011 Jul; 8(7):1101-4. PMID: 21255680; PMCID: PMC3129479.
    139. Song Q, Pallikkuth S, Bossuyt J, Bers D, Robia SL. Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase. J Biol Chem. 2011 Mar 18; 286(11):9120-6. PMID: 21220422; PMCID: PMC3059012.
    140. Puglisi JL, Yuan W, Timofeyev V, Myers RE, Chiamvimonvat N, Samarel AM, Bers D. Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. Am J Physiol Heart Circ Physiol. 2011 Feb; 300(2):H617-26. PMID: 21131481; PMCID: PMC3044063.
    141. Mishra S, Ling H, Grimm M, Zhang T, Bers D, Brown JH. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J Cardiovasc Pharmacol. 2010 Dec; 56(6):598-603. PMID: 20531218; PMCID: PMC2947575.
    142. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers D, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79. PMID: 21098440; PMCID: PMC3075419.
    143. Xu H, Ginsburg KS, Hall DD, Zimmermann M, Stein IS, Zhang M, Tandan S, Hill JA, Horne MC, Bers D, Hell JW. Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry. 2010 Dec 07; 49(48):10298-307. PMID: 21053940; PMCID: PMC3075818.
    144. Bers D. CaMKII inhibition in heart failure makes jump to human. Circ Res. 2010 Oct 29; 107(9):1044-6. PMID: 21030721.
      View in: PubMed
    145. Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers D. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIdC. J Mol Cell Cardiol. 2011 Jan; 50(1):230-8. PMID: 20971119.
      View in: PubMed
    146. Zima AV, Bovo E, Bers D, Blatter LA. Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol. 2010 Dec 01; 588(Pt 23):4743-57. PMID: 20962003; PMCID: PMC3010143.
    147. Han F, Bossuyt J, Martin JL, Despa S, Bers D. Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1363-9. PMID: 20861470; PMCID: PMC3006338.
    148. Bers D. Digitalis and Na/Ca exchange: old dog learns new mitochondrial tricks. J Mol Cell Cardiol. 2010 Nov; 49(5):713-4. PMID: 20708015; PMCID: PMC2949520.
    149. Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers D, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res. 2010 Sep 03; 107(5):659-66. PMID: 20616315; PMCID: PMC2933281.
    150. Santiago DJ, Curran JW, Bers D, Lederer WJ, Stern MD, Ríos E, Shannon TR. Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J. 2010 May 19; 98(10):2111-20. PMID: 20483318; PMCID: PMC2872235.
    151. Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, Fruen BR, Bers D. Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res. 2010 Jun 11; 106(11):1743-52. PMID: 20431056; PMCID: PMC2895429.
    152. Curran J, Brown KH, Santiago DJ, Pogwizd S, Bers D, Shannon TR. Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II. J Mol Cell Cardiol. 2010 Jul; 49(1):25-32. PMID: 20353795; PMCID: PMC2883657.
    153. Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers D, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2001-9. PMID: 20304816; PMCID: PMC2886636.
    154. Bers D. Calcium channels are ganging up in the sarcolemma. Circ Res. 2010 Mar 05; 106(4):625-6. PMID: 20203310; PMCID: PMC2839079.
    155. Grandi E, Morotti S, Ginsburg KS, Severi S, Bers D. Interplay of voltage and Ca-dependent inactivation of L-type Ca current. Prog Biophys Mol Biol. 2010 Sep; 103(1):44-50. PMID: 20184915; PMCID: PMC2907421.
    156. Bers D, Ginsburg KS. Minding the store of Ca2+ during ischaemia/reperfusion. Cardiovasc Res. 2010 Mar 01; 85(4):641-2. PMID: 20056726.
      View in: PubMed
    157. Bers D, Patton CW, Nuccitelli R. A practical guide to the preparation of Ca(2+) buffers. Methods Cell Biol. 2010; 99:1-26. PMID: 21035681.
      View in: PubMed
    158. Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers D, Brown JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010 Feb 05; 106(2):354-62. PMID: 19959778; PMCID: PMC2818826.
    159. Grandi E, Pasqualini FS, Bers D. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan; 48(1):112-21. PMID: 19835882; PMCID: PMC2813400.
    160. Bers D, Grandi E. Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels. J Cardiovasc Pharmacol. 2009 Sep; 54(3):180-7. PMID: 19333131; PMCID: PMC2784004.
    161. Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers D, Kelly DP. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1263-73. PMID: 19700627; PMCID: PMC2770758.
    162. Bossuyt J, Despa S, Han F, Hou Z, Robia SL, Lingrel JB, Bers D. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem. 2009 Sep 25; 284(39):26749-57. PMID: 19638348; PMCID: PMC2785363.
    163. Han F, Tucker AL, Lingrel JB, Despa S, Bers D. Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. Am J Physiol Cell Physiol. 2009 Sep; 297(3):C699-705. PMID: 19570895; PMCID: PMC2740389.
    164. Bers D, Despa S. Na/K-ATPase--an integral player in the adrenergic fight-or-flight response. Trends Cardiovasc Med. 2009 May; 19(4):111-8. PMID: 19818946; PMCID: PMC2761231.
    165. Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH, Heller Brown J. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009 May; 119(5):1230-40. PMID: 19381018; PMCID: PMC2673879.
    166. Wagner S, Hacker E, Grandi E, Weber SL, Dybkova N, Sossalla S, Sowa T, Fabritz L, Kirchhof P, Bers D, Maier LS. Ca/calmodulin kinase II differentially modulates potassium currents. Circ Arrhythm Electrophysiol. 2009 Jun; 2(3):285-94. PMID: 19808479; PMCID: PMC2734104.
    167. Andrienko TN, Picht E, Bers D. Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes. J Mol Cell Cardiol. 2009 Jun; 46(6):1027-36. PMID: 19345225; PMCID: PMC2683203.
    168. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, Peterson KL, Richard S, Bers D, Brown JH, Condorelli G. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol. 2009 Mar 23; 184(6):923-33. PMID: 19307602; PMCID: PMC2699149.
    169. Murphy E, Bers D, Rizzuto R. Mitochondria: from basic biology to cardiovascular disease. J Mol Cell Cardiol. 2009 Jun; 46(6):765-6. PMID: 19289126.
      View in: PubMed
    170. Bers D, Despa S. Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling. IUBMB Life. 2009 Mar; 61(3):215-21. PMID: 19243007; PMCID: PMC2669704.
    171. Bers D. Some just can't say enough in the new JMCC Point-Counterpoint feature. J Mol Cell Cardiol. 2009 Feb; 46(2):117. PMID: 19146998.
      View in: PubMed
    172. Waggoner JR, Ginsburg KS, Mitton B, Haghighi K, Robbins J, Bers D, Kranias EG. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H698-703. PMID: 19112098; PMCID: PMC2660221.
    173. Liang S, Yang F, Zhou C, Wang Y, Li S, Sun CK, Puglisi JL, Bers D, Sun C, Zheng J. Temperature-dependent activation of neurons by continuous near-infrared laser. Cell Biochem Biophys. 2009; 53(1):33-42. PMID: 19034696; PMCID: PMC4019448.
    174. Song Q, Saucerman JJ, Bossuyt J, Bers D. Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem. 2008 Nov 14; 283(46):31531-40. PMID: 18790737; PMCID: PMC2581591.
    175. Zima AV, Picht E, Bers D, Blatter LA. Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res. 2008 Oct 10; 103(8):e105-15. PMID: 18787194; PMCID: PMC2678058.
    176. Rudy Y, Ackerman MJ, Bers D, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 2008 Sep 09; 118(11):1202-11. PMID: 18779456; PMCID: PMC2908516.
    177. Huke S, Bers D. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun. 2008 Nov 07; 376(1):80-5. PMID: 18755143; PMCID: PMC2581610.
    178. Saucerman JJ, Bers D. Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J. 2008 Nov 15; 95(10):4597-612. PMID: 18689454; PMCID: PMC2576378.
    179. Bers D, Eisner D. Point/counterpoint: a new feature in the JMCC. J Mol Cell Cardiol. 2008 Jun; 44(6):949. PMID: 18541159.
      View in: PubMed
    180. Terentyev D, Kubalova Z, Valle G, Nori A, Vedamoorthyrao S, Terentyeva R, Viatchenko-Karpinski S, Bers D, Williams SC, Volpe P, Gyorke S. Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J. 2008 Aug; 95(4):2037-48. PMID: 18469084; PMCID: PMC2483765.
    181. Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers D, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 06; 102(11):1389-97. PMID: 18467626; PMCID: PMC2585979.
    182. Despa S, Tucker AL, Bers D. Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes. Circulation. 2008 Apr 08; 117(14):1849-55. PMID: 18362230; PMCID: PMC2854005.
    183. Kelly EM, Hou Z, Bossuyt J, Bers D, Robia SL. Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells. J Biol Chem. 2008 May 02; 283(18):12202-11. PMID: 18287099; PMCID: PMC2335368.
    184. Rice JJ, Wang F, Bers D, de Tombe PP. Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J. 2008 Sep; 95(5):2368-90. PMID: 18234826; PMCID: PMC2517033.
    185. Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers D. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008 Mar 28; 102(6):695-702. PMID: 18218981.
      View in: PubMed
    186. Bers D. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol. 2008; 70:23-49. PMID: 17988210.
      View in: PubMed
    187. Zima AV, Picht E, Bers D, Blatter LA. Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophys J. 2008 Mar 01; 94(5):1867-79. PMID: 18024505; PMCID: PMC2242770.
    188. Zhang T, Kohlhaas M, Backs J, Mishra S, Phillips W, Dybkova N, Chang S, Ling H, Bers D, Maier LS, Olson EN, Brown JH. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30; 282(48):35078-87. PMID: 17923476.
      View in: PubMed
    189. Guo T, Ai X, Shannon TR, Pogwizd SM, Bers D. Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circ Res. 2007 Oct 12; 101(8):802-10. PMID: 17704210.
      View in: PubMed
    190. Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers D. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007 Dec 01; 93(11):3835-47. PMID: 17704163; PMCID: PMC2084250.
    191. Bers D. Going to cAMP just got more complicated. J Physiol. 2007 Sep 01; 583(Pt 2):415-6. PMID: 17656427; PMCID: PMC2277018.
    192. Altamirano J, Bers D. Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circ Res. 2007 Sep 14; 101(6):590-7. PMID: 17641229.
      View in: PubMed
    193. Altamirano J, Bers D. Effect of intracellular Ca2+ and action potential duration on L-type Ca2+ channel inactivation and recovery from inactivation in rabbit cardiac myocytes. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H563-73. PMID: 17400724.
      View in: PubMed
    194. Despa S, Bers D. Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C321-7. PMID: 17392375.
      View in: PubMed
    195. Higgins ER, Goel P, Puglisi JL, Bers D, Cannell M, Sneyd J. Modelling calcium microdomains using homogenisation. J Theor Biol. 2007 Aug 21; 247(4):623-44. PMID: 17499276; PMCID: PMC1991275.
    196. Picht E, Zima AV, Blatter LA, Bers D. SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C1073-81. PMID: 17376815.
      View in: PubMed
    197. Bers D, Ginsburg KS. Na:Ca stoichiometry and cytosolic Ca-dependent activation of NCX in intact cardiomyocytes. Ann N Y Acad Sci. 2007 Mar; 1099:326-38. PMID: 17303827.
      View in: PubMed
    198. Curran J, Hinton MJ, Ríos E, Bers D, Shannon TR. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007 Feb 16; 100(3):391-8. PMID: 17234966.
      View in: PubMed
    199. Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers D, Dorn GW, Wang HS, Valdivia HH, Chu G, Kranias EG. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation. 2007 Jan 23; 115(3):300-9. PMID: 17224479.
      View in: PubMed
    200. Maier LS, Bers D, Brown JH. Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology. Cardiovasc Res. 2007 Mar 01; 73(4):629-30. PMID: 17258179.
      View in: PubMed
    201. Islamovic E, Duncan A, Bers D, Gerthoffer WT, Mestril R. Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection. J Mol Cell Cardiol. 2007 Apr; 42(4):862-9. PMID: 17292395.
      View in: PubMed
    202. Puglisi JL, Wehrmacher WH, Messmore H, Bers D. Pulmonary arterial hypertension. Compr Ther. 2007; 33(4):231-6. PMID: 18025615.
      View in: PubMed
    203. Huke S, Bers D. Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol. 2007 Mar; 42(3):590-9. PMID: 17239900; PMCID: PMC1857340.
    204. Bers D. Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda). 2006 Dec; 21:380-7. PMID: 17119150.
      View in: PubMed
    205. Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers D, Valdivia HH, Cheng H, Kass DA, Paolocci N. Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res. 2007 Jan 05; 100(1):96-104. PMID: 17138943; PMCID: PMC2769513.
    206. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers D, Maier LS. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 2006 Dec; 116(12):3127-38. PMID: 17124532; PMCID: PMC1654201.
    207. Berry RG, Despa S, Fuller W, Bers D, Shattock MJ. Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovasc Res. 2007 Jan 01; 73(1):92-100. PMID: 17157829.
      View in: PubMed
    208. Maier LS, Bers D. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 2007 Mar 01; 73(4):631-40. PMID: 17157285.
      View in: PubMed
    209. Han F, Bossuyt J, Despa S, Tucker AL, Bers D. Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res. 2006 Dec 08; 99(12):1376-83. PMID: 17095720.
      View in: PubMed
    210. Bers D. The beat goes on: diastolic noise that just won't quit. Circ Res. 2006 Oct 27; 99(9):921-3. PMID: 17068299.
      View in: PubMed
    211. Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers D. CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol. 2007 Jan; 42(1):196-205. PMID: 17052727; PMCID: PMC1828135.
    212. Bers D, Despa S, Bossuyt J. Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes. Ann N Y Acad Sci. 2006 Oct; 1080:165-77. PMID: 17132783.
      View in: PubMed
    213. Wu X, Bers D. Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium. 2007 Apr; 41(4):353-64. PMID: 16999996; PMCID: PMC1868497.
    214. Maier LS, Ziolo MT, Bossuyt J, Persechini A, Mestril R, Bers D. Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes. J Mol Cell Cardiol. 2006 Sep; 41(3):451-8. PMID: 16765983.
      View in: PubMed
    215. Picht E, DeSantiago J, Blatter LA, Bers D. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res. 2006 Sep 29; 99(7):740-8. PMID: 16946134.
      View in: PubMed
    216. Bossuyt J, Despa S, Martin JL, Bers D. Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J Biol Chem. 2006 Oct 27; 281(43):32765-73. PMID: 16943195.
      View in: PubMed
    217. Guo T, Zhang T, Mestril R, Bers D. Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res. 2006 Aug 18; 99(4):398-406. PMID: 16840718.
      View in: PubMed
    218. Altamirano J, Li Y, DeSantiago J, Piacentino V, Houser SR, Bers D. The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. J Physiol. 2006 Sep 15; 575(Pt 3):845-54. PMID: 16825310; PMCID: PMC1995692.
    219. Wu X, Bers D. Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res. 2006 Aug 04; 99(3):283-91. PMID: 16794184.
      View in: PubMed
    220. Bers D. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem J. 2006 May 15; 396(1):e1-3. PMID: 16626281; PMCID: PMC1450001.
    221. Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA, Mitton BA, Waggoner JR, Del Monte F, Park WJ, Dorn GW, Bers D, Kranias EG. Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. J Mol Cell Cardiol. 2006 May; 40(5):653-65. PMID: 16600288.
      View in: PubMed
    222. Bers D, Despa S. Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts. J Pharmacol Sci. 2006; 100(5):315-22. PMID: 16552170.
      View in: PubMed
    223. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers D. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006 Mar; 116(3):675-82. PMID: 16511602; PMCID: PMC1386110.
    224. Sun J, Picht E, Ginsburg KS, Bers D, Steenbergen C, Murphy E. Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res. 2006 Feb 17; 98(3):403-11. PMID: 16397145.
      View in: PubMed
    225. Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, Steen A, Wagner S, Chen L, Brown JH, Bers D, Maier LS. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res. 2006 Feb 03; 98(2):235-44. PMID: 16373600.
      View in: PubMed
    226. Ai X, Curran JW, Shannon TR, Bers D, Pogwizd SM. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005 Dec 09; 97(12):1314-22. PMID: 16269653.
      View in: PubMed
    227. Remus TP, Zima AV, Bossuyt J, Bare DJ, Martin JL, Blatter LA, Bers D, Mignery GA. Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. J Biol Chem. 2006 Jan 06; 281(1):608-16. PMID: 16249182.
      View in: PubMed
    228. Ginsburg KS, Bers D. Isoproterenol does not enhance Ca-dependent Na/Ca exchange current in intact rabbit ventricular myocytes. J Mol Cell Cardiol. 2005 Dec; 39(6):972-81. PMID: 16242149.
      View in: PubMed
    229. Brette F, Despa S, Bers D, Orchard CH. Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol. 2005 Nov; 39(5):804-12. PMID: 16198369.
      View in: PubMed
    230. Shannon TR, Wang F, Bers D. Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J. 2005 Dec; 89(6):4096-110. PMID: 16169970; PMCID: PMC1366975.
    231. Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers D, Dedman JR. Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H599-606. PMID: 16143658.
      View in: PubMed
    232. Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers D. Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res. 2005 Sep 16; 97(6):558-65. PMID: 16100047.
      View in: PubMed
    233. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers D. Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res. 2005 Aug 05; 97(3):252-9. PMID: 16002746.
      View in: PubMed
    234. Bers D, Guo T. Calcium signaling in cardiac ventricular myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:86-98. PMID: 16093487.
      View in: PubMed
    235. Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers D, Zinman B, Lakatta EG, Robbins J. Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation. 2005 May 10; 111(18):2330-8. PMID: 15867176; PMCID: PMC1314982.
    236. Bers D. Beyond beta blockers. Nat Med. 2005 Apr; 11(4):379-80. PMID: 15812516.
      View in: PubMed
    237. Ziolo MT, Martin JL, Bossuyt J, Bers D, Pogwizd SM. Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function. Circ Res. 2005 Apr 29; 96(8):815-7. PMID: 15790952.
      View in: PubMed
    238. Bare DJ, Kettlun CS, Liang M, Bers D, Mignery GA. Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem. 2005 Apr 22; 280(16):15912-20. PMID: 15710625.
      View in: PubMed
    239. Wehrmacher WH, Puglisi JL, Bers D, Messmore H. Sudden unexpected death. Compr Ther. 2005; 31(3):176-80. PMID: 16110125.
      View in: PubMed
    240. Teucher N, Prestle J, Seidler T, Currie S, Elliott EB, Reynolds DF, Schott P, Wagner S, Kogler H, Inesi G, Bers D, Hasenfuss G, Smith GL. Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation. 2004 Dec 07; 110(23):3553-9. PMID: 15505097.
      View in: PubMed
    241. Shannon TR, Wang F, Puglisi J, Weber C, Bers D. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J. 2004 Nov; 87(5):3351-71. PMID: 15347581; PMCID: PMC1304803.
    242. Chaudhary KW, Rossman EI, Piacentino V, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers D, Houser SR, Margulies KB. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart. J Am Coll Cardiol. 2004 Aug 18; 44(4):837-45. PMID: 15312868.
      View in: PubMed
    243. Bers D. Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol. 2004 Aug; 37(2):417-29. PMID: 15276012.
      View in: PubMed
    244. Despa S, Kockskämper J, Blatter LA, Bers D. Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy. Biophys J. 2004 Aug; 87(2):1360-8. PMID: 15298938; PMCID: PMC1304474.
    245. Bassani RA, Altamirano J, Puglisi JL, Bers D. Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes. J Physiol. 2004 Sep 01; 559(Pt 2):593-609. PMID: 15243136; PMCID: PMC1665117.
    246. Puglisi JL, Wang F, Bers D. Modeling the isolated cardiac myocyte. Prog Biophys Mol Biol. 2004 Jun-Jul; 85(2-3):163-78. PMID: 15142742.
      View in: PubMed
    247. Shannon TR, Bers D. Integrated Ca2+ management in cardiac myocytes. Ann N Y Acad Sci. 2004 May; 1015:28-38. PMID: 15201147.
      View in: PubMed
    248. Ziolo MT, Maier LS, Piacentino V, Bossuyt J, Houser SR, Bers D. Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients. Circulation. 2004 Apr 20; 109(15):1886-91. PMID: 15037528.
      View in: PubMed
    249. Pogwizd SM, Bers D. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med. 2004 Feb; 14(2):61-6. PMID: 15030791.
      View in: PubMed
    250. Ginsburg KS, Bers D. Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol. 2004 Apr 15; 556(Pt 2):463-80. PMID: 14724205; PMCID: PMC1664945.
    251. Weber CR, Piacentino V, Houser SR, Bers D. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation. 2003 Nov 04; 108(18):2224-9. PMID: 14557358.
      View in: PubMed
    252. Bers D, Eisner DA, Valdivia HH. Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res. 2003 Sep 19; 93(6):487-90. PMID: 14500331.
      View in: PubMed
    253. Shannon TR, Pogwizd SM, Bers D. Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res. 2003 Oct 03; 93(7):592-4. PMID: 12946948.
      View in: PubMed
    254. Lipsius SL, Bers D. Cardiac pacemaking: I(f) vs. Ca(2+), is it really that simple? J Mol Cell Cardiol. 2003 Aug; 35(8):891-3. PMID: 12878475.
      View in: PubMed
    255. Kirchhefer U, Neumann J, Bers D, Buchwalow IB, Fabritz L, Hanske G, Justus I, Riemann B, Schmitz W, Jones LR. Impaired relaxation in transgenic mice overexpressing junctin. Cardiovasc Res. 2003 Aug 01; 59(2):369-79. PMID: 12909320.
      View in: PubMed
    256. Ziolo MT, Bers D. The real estate of NOS signaling: location, location, location. Circ Res. 2003 Jun 27; 92(12):1279-81. PMID: 12829613.
      View in: PubMed
    257. Shannon TR, Guo T, Bers D. Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res. 2003 Jul 11; 93(1):40-5. PMID: 12791706.
      View in: PubMed
    258. Despa S, Bers D. Na/K pump current and [Na](i) in rabbit ventricular myocytes: local [Na](i) depletion and Na buffering. Biophys J. 2003 Jun; 84(6):4157-66. PMID: 12770918; PMCID: PMC1302994.
    259. Weber CR, Ginsburg KS, Bers D. Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current. Circ Res. 2003 May 16; 92(9):950-2. PMID: 12702644.
      View in: PubMed
    260. Bers D. Dynamic imaging in living cells: windows into local signaling. Sci STKE. 2003 Apr 08; 2003(177):PE13. PMID: 12684526.
      View in: PubMed
    261. Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers D. Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res. 2003 May 02; 92(8):904-11. PMID: 12676813.
      View in: PubMed
    262. Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J, Bers D, Brown JH. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res. 2003 May 02; 92(8):912-9. PMID: 12676814.
      View in: PubMed
    263. Pieske B, Houser SR, Hasenfuss G, Bers D. Sodium and the heart: a hidden key factor in cardiac regulation. Cardiovasc Res. 2003 Mar 15; 57(4):871-2. PMID: 12650864.
      View in: PubMed
    264. Pogwizd SM, Sipido KR, Verdonck F, Bers D. Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovasc Res. 2003 Mar 15; 57(4):887-96. PMID: 12650867.
      View in: PubMed
    265. Bers D, Barry WH, Despa S. Intracellular Na+ regulation in cardiac myocytes. Cardiovasc Res. 2003 Mar 15; 57(4):897-912. PMID: 12650868.
      View in: PubMed
    266. von Lewinski D, Stumme B, Maier LS, Luers C, Bers D, Pieske B. Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent. Cardiovasc Res. 2003 Mar 15; 57(4):1052-61. PMID: 12650883.
      View in: PubMed
    267. Brittsan AG, Ginsburg KS, Chu G, Yatani A, Wolska BM, Schmidt AG, Asahi M, MacLennan DH, Bers D, Kranias EG. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circ Res. 2003 Apr 18; 92(7):769-76. PMID: 12637367.
      View in: PubMed
    268. Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers D, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res. 2003 Apr 04; 92(6):651-8. PMID: 12600875.
      View in: PubMed
    269. Ginsburg KS, Weber CR, Despa S, Bers D. Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes. Ann N Y Acad Sci. 2002 Nov; 976:157-8. PMID: 12502556.
      View in: PubMed
    270. Weber CR, Piacentino V, Margulies KB, Bers D, Houser SR. Calcium influx via I(NCX) is favored in failing human ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:478-9. PMID: 12502599.
      View in: PubMed
    271. Pogwizd SM, Bers D. Na/Ca exchange in heart failure: contractile dysfunction and arrhythmogenesis. Ann N Y Acad Sci. 2002 Nov; 976:454-65. PMID: 12502595.
      View in: PubMed
    272. Piacentino V, Weber CR, Gaughan JP, Margulies KB, Bers D, Houser SR. Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Ann N Y Acad Sci. 2002 Nov; 976:466-71. PMID: 12502596.
      View in: PubMed
    273. Bers D, Weber CR. Na/Ca exchange function in intact ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:500-12. PMID: 12502604.
      View in: PubMed
    274. Shannon TR, Ginsburg KS, Bers D. Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res. 2002 Oct 04; 91(7):594-600. PMID: 12364387.
      View in: PubMed
    275. Maier LS, Bers D. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol. 2002 Aug; 34(8):919-39. PMID: 12234763.
      View in: PubMed
    276. Brandes R, Bers D. Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J. 2002 Aug; 83(2):587-604. PMID: 12124250; PMCID: PMC1302172.
    277. DeSantiago J, Maier LS, Bers D. Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol. 2002 Aug; 34(8):975-84. PMID: 12234767.
      View in: PubMed
    278. Zhou Z, Bers D. Time course of action of antagonists of mitochondrial Ca uptake in intact ventricular myocytes. Pflugers Arch. 2002 Oct; 445(1):132-8. PMID: 12397397.
      View in: PubMed
    279. Bers D. Sarcoplasmic reticulum Ca release in intact ventricular myocytes. Front Biosci. 2002 Jul 01; 7:d1697-711. PMID: 12086924.
      View in: PubMed
    280. Despa S, Islam MA, Weber CR, Pogwizd SM, Bers D. Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 2002 May 28; 105(21):2543-8. PMID: 12034663.
      View in: PubMed
    281. Bers D. Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference? J Mol Cell Cardiol. 2002 Apr; 34(4):369-73. PMID: 11991726.
      View in: PubMed
    282. Li Y, Kranias EG, Mignery GA, Bers D. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res. 2002 Feb 22; 90(3):309-16. PMID: 11861420.
      View in: PubMed
    283. Despa S, Islam MA, Pogwizd SM, Bers D. Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol. 2002 Feb 15; 539(Pt 1):133-43. PMID: 11850507; PMCID: PMC2290132.
    284. Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers D. Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res. 2002 Feb 08; 90(2):182-9. PMID: 11834711.
      View in: PubMed
    285. Bers D. Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res. 2002 Jan 11; 90(1):14-7. PMID: 11786512.
      View in: PubMed
    286. Bers D. Cardiac excitation-contraction coupling. Nature. 2002 Jan 10; 415(6868):198-205. PMID: 11805843.
      View in: PubMed
    287. Bers D, Pogwizd SM, Schlotthauer K. Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Res Cardiol. 2002; 97 Suppl 1:I36-42. PMID: 12479232.
      View in: PubMed
    288. Pogwizd SM, Bers D. Calcium cycling in heart failure: the arrhythmia connection. J Cardiovasc Electrophysiol. 2002 Jan; 13(1):88-91. PMID: 11843491.
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