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Florin Despa

TitleAsst Prof
InstitutionUniversity of California Davis
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stewart BD, Scott CE, McCoy TP, Yin G, Despa F, Despa S, Kekenes-Huskey PM. Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes. Cell Calcium. 2018 May; 71:65-74. PMID: 29604965.
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    2. Liu M, Hoskins A, Verma N, Bers DM, Despa S, Despa F. Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium. Biochim Biophys Acta. 2018 May; 1864(5 Pt B):1923-1930. PMID: 29066284.
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    3. Ly H, Verma N, Wu F, Liu M, Saatman KE, Nelson PT, Slevin JT, Goldstein LB, Biessels GJ, Despa F. Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. Ann Neurol. 2017 Aug; 82(2):208-222. PMID: 28696548.
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    4. Van Steenbergen A, Balteau M, Ginion A, Ferté L, Battault S, Ravenstein CM, Balligand JL, Daskalopoulos EP, Gilon P, Despa F, Despa S, Vanoverschelde JL, Horman S, Koepsell H, Berry G, Hue L, Bertrand L, Beauloye C. Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart. Sci Rep. 2017 Jan 27; 7:41166. PMID: 28128227.
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    5. Liu M, Verma N, Peng X, Srodulski S, Morris A, Chow M, Hersh LB, Chen J, Zhu H, Netea MG, Margulies KB, Despa S, Despa F. Hyperamylinemia Increases IL-1ß Synthesis in the Heart via Peroxidative Sarcolemmal Injury. Diabetes. 2016 09; 65(9):2772-83. PMID: 27335231.
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    6. Verma N, Ly H, Liu M, Chen J, Zhu H, Chow M, Hersh LB, Despa F. Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1ß Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. J Alzheimers Dis. 2016 05 05; 53(1):259-72. PMID: 27163815; PMCID: PMC4920720.
    7. Ilaiwy A, Liu M, Parry TL, Bain JR, Newgard CB, Schisler JC, Muehlbauer MJ, Despa F, Willis MS. Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo. Metabolomics. 2016 May; 12(5). PMID: 28775675.
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    8. Ly H, Despa F. Hyperamylinemia as a risk factor for accelerated cognitive decline in diabetes. Expert Rev Proteomics. 2015; 12(6):575-7. PMID: 26503000; PMCID: PMC4913469.
    9. Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa S. Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. J Am Heart Assoc. 2015 Aug 27; 4(9):e002183. PMID: 26316524; PMCID: PMC4599504.
    10. Guan H, Chow KM, Song E, Verma N, Despa F, Hersh LB. The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. PLoS One. 2015; 10(7):e0133263. PMID: 26191799; PMCID: PMC4507941.
    11. Srodulski S, Sharma S, Bachstetter AB, Brelsfoard JM, Pascual C, Xie XS, Saatman KE, Van Eldik LJ, Despa F. Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Mol Neurodegener. 2014 Aug 22; 9:30. PMID: 25149184; PMCID: PMC4144699.
    12. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc. 2014 Aug 21; 3(4). PMID: 25146704.
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    13. Despa F, Decarli C. Amylin: what might be its role in Alzheimer's disease and how could this affect therapy? Expert Rev Proteomics. 2013 Oct; 10(5):403-5. PMID: 24117198; PMCID: PMC4068803.
    14. Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM, Bers DM. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 2013 Oct 17; 502(7471):372-6. PMID: 24077098; PMCID: PMC3801227.
    15. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F. Amylin deposition in the brain: A second amyloid in Alzheimer disease? Ann Neurol. 2013 Oct; 74(4):517-26. PMID: 23794448; PMCID: PMC3818462.
    16. Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H853-62. PMID: 22865388; PMCID: PMC3469704.
    17. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. PMID: 22275486; PMCID: PMC3303627.
    18. Walton JH, Berry RS, Despa F. Amyloid oligomer formation probed by water proton magnetic resonance spectroscopy. Biophys J. 2011 May 04; 100(9):2302-8. PMID: 21539800; PMCID: PMC3149262.
    19. Ionescu-Tirgoviste C, Despa F. Biophysical alteration of the secretory track in ß-cells due to molecular overcrowding: the relevance for diabetes. Integr Biol (Camb). 2011 Mar; 3(3):173-9. PMID: 21180710.
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    20. Despa F, Berry RS. ß-Cell dysfunction under hyperglycemic stress: a molecular model. J Diabetes Sci Technol. 2010 Nov 01; 4(6):1447-56. PMID: 21129340; PMCID: PMC3005055.
    21. Despa F. Endoplasmic reticulum overcrowding as a mechanism of beta-cell dysfunction in diabetes. Biophys J. 2010 Apr 21; 98(8):1641-8. PMID: 20409485; PMCID: PMC2856141.
    22. Despa F, Luo JT, Li J, Duan Y, Lam KS. Cholic acid micelles--controlling the size of the aqueous cavity by PEGylation. Phys Chem Chem Phys. 2010 Feb 21; 12(7):1589-94. PMID: 20126774.
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    23. Despa F, Basati S, Zhang ZD, D'Andrea J, Reilly JP, Bodnar EN, Lee RC. Electromuscular incapacitation results from stimulation of spinal reflexes. Bioelectromagnetics. 2009 Jul; 30(5):411-21. PMID: 19353595.
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    24. Despa F. Dilation of the endoplasmic reticulum in beta cells due to molecular overcrowding? Kinetic simulations of extension limits and consequences on proinsulin synthesis. Biophys Chem. 2009 Mar; 140(1-3):115-21. PMID: 19121888.
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    25. Despa F, Fernández A, Scott LR, Berry RS. Hydration profiles of amyloidogenic molecular structures. J Biol Phys. 2008 Dec; 34(6):577-90. PMID: 19669515; PMCID: PMC2603265.
    26. Despa F, Berry RS. Hydrophobe-water interactions: methane as a model. Biophys J. 2008 Nov 01; 95(9):4241-5. PMID: 18676647; PMCID: PMC2567944.
    27. Despa F. Water confined in reverse micelles--probe tool in biomedical informatics. Phys Chem Chem Phys. 2008 Aug 28; 10(32):4740-7. PMID: 18688516.
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    28. Collins JM, Despa F, Lee RC. Structural and functional recovery of electropermeabilized skeletal muscle in-vivo after treatment with surfactant poloxamer 188. Biochim Biophys Acta. 2007 May; 1768(5):1238-46. PMID: 17382288; PMCID: PMC1919408.
    29. Despa F, Berry RS. The origin of long-range attraction between hydrophobes in water. Biophys J. 2007 Jan 15; 92(2):373-8. PMID: 16997876; PMCID: PMC1751411.
    30. Lee RC, Despa F, Guo L, Betala P, Kuo A, Thiyagarajan P. Surfactant copolymers prevent aggregation of heat denatured lysozyme. Ann Biomed Eng. 2006 Jul; 34(7):1190-200. PMID: 16786393; PMCID: PMC3027126.
    31. Despa F, Orgill DP, Lee RC. Molecular crowding effects on protein stability. Ann N Y Acad Sci. 2005 Dec; 1066:54-66. PMID: 16533918.
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    32. Despa F. Biological water: Its vital role in macromolecular structure and function. Ann N Y Acad Sci. 2005 Dec; 1066:1-11. PMID: 16533915.
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    33. Gissel H, Despa F, Collins J, Mustafi D, Rojahn K, Karczmar G, Lee R. Magnetic resonance imaging of changes in muscle tissues after membrane trauma. Ann N Y Acad Sci. 2005 Dec; 1066:272-85. PMID: 16533931.
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    34. Despa F, Orgill DP, Lee RC. Effects of crowding on the thermal stability of heterogeneous protein solutions. Ann Biomed Eng. 2005 Aug; 33(8):1125-31. PMID: 16133920.
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    35. Despa F, Orgill DP, Neuwalder J, Lee RC. The relative thermal stability of tissue macromolecules and cellular structure in burn injury. Burns. 2005 Aug; 31(5):568-77. PMID: 15993302.
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    36. Despa F, Wales DJ, Berry RS. Archetypal energy landscapes: dynamical diagnosis. J Chem Phys. 2005 Jan 08; 122(2):024103. PMID: 15638568.
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    37. Lee RC, Despa F. Distinguishing electroporation from thermal injuries in electrical shock by MR imaging. Conf Proc IEEE Eng Med Biol Soc. 2005; 6:6544-6. PMID: 17281769.
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    38. Despa F, Fernández A, Berry RS. Dielectric modulation of biological water. Phys Rev Lett. 2004 Nov 26; 93(22):228104. PMID: 15601122.
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    39. Despa F, Berry RS. How much can an intermediate state influence competing reactive pathways? J Chem Phys. 2004 Mar 15; 120(11):5164-8. PMID: 15267386.
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    40. Despa F, Orgill DP, Lee RC. Stability of cellular proteins under supraphysiological temperatures. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5440-3. PMID: 17271577.
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    41. Lee RC, Despa F, Collins JC, Karczmar G, Tenchov B. Magnetic resonance imaging of muscle electroporation injury. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5451-4. PMID: 17271580.
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