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Gino A Cortopassi

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi G, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 01; 27(5):1156. PMID: 29719228.
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    2. Finno CJ, Bordbari MH, Gianino G, Ming-Whitfield B, Burns E, Merkel J, Britton M, Durbin-Johnson B, Sloma EA, McMackin M, Cortopassi G, Rivas V, Barro M, Tran CK, Gennity I, Habib H, Xu L, Puschner B, Miller AD. An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. Free Radic Biol Med. 2018 May 20; 120:289-302. PMID: 29526809.
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    3. Yu AK, Datta S, McMackin MZ, Cortopassi G. Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules. Hum Mol Genet. 2017 Dec 15; 26(24):4929-4936. PMID: 29040550.
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    4. Teixeira J, Amorim R, Santos K, Soares P, Datta S, Cortopassi G, Serafim TL, Sardão VA, Garrido J, Borges F, Oliveira PJ. Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative. Toxicology. 2018 01 15; 393:123-139. PMID: 29141199.
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    5. Kathrani A, Larsen JA, Cortopassi G, Datta S, Fascetti AJ. A descriptive pilot study of cytokine production following stimulation of ex-vivo whole blood with commercial therapeutic feline hydrolyzed diets in individual healthy immunotolerant cats. BMC Vet Res. 2017 Oct 06; 13(1):297. PMID: 28985721.
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    6. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi G, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. PMID: 28877457.
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    7. Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. PMID: 28885978.
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    8. Hayashi G, Jasoliya M, Sahdeo S, Saccà F, Pane C, Filla A, Marsili A, Puorro G, Lanzillo R, Brescia Morra V, Cortopassi G. Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans. Hum Mol Genet. 2017 08 01; 26(15):2864-2873. PMID: 28460056.
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    9. Jasoliya MJ, McMackin MZ, Henderson CK, Perlman SL, Cortopassi G. Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans. Hum Mol Genet. 2017 07 15; 26(14):2627-2633. PMID: 28444186.
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    10. Scharadin TM, He W, Yiannakou Y, Tomilov AA, Saldana M, Cortopassi G, Carraway KL, Coleman MA, Henderson PT. Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLoS One. 2017; 12(6):e0177761. PMID: 28586369.
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    11. Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi G. The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Invest Ophthalmol Vis Sci. 2017 04 01; 58(4):2406-2412. PMID: 28444329.
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    12. Song L, McMackin M, Nguyen A, Cortopassi G. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiol Dis. 2017 Apr; 100:30-38. PMID: 28042097.
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    13. Song L, Yu A, Murray K, Cortopassi G. Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. 2017 02 15; 1657:232-244. PMID: 28027875.
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    14. Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G. A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. 2016 Nov; 31:79-83. PMID: 27717841.
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    15. Tian J, Yang G, Chen HY, Hsu DK, Tomilov A, Olson KA, Dehnad A, Fish SR, Cortopassi G, Zhao B, Liu FT, Gershwin ME, Török NJ, Jiang JX. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016 12; 30(12):4202-4213. PMID: 27630169.
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    16. McMackin MZ, Henderson CK, Cortopassi G. Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia. Behav Brain Res. 2017 01 01; 316:183-188. PMID: 27575947.
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    17. Datta S, Tomilov A, Cortopassi G. Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. 2016 09; 30:177-86. PMID: 27497748; PMCID: PMC5039017 [Available on 09/01/17].
    18. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi G, Ramsey JJ. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. PMID: 28133633.
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    19. Darr CR, Varner DD, Teague S, Cortopassi G, Datta S, Meyers SA. Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production. Biol Reprod. 2016 08; 95(2):34. PMID: 27335066.
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    20. Darr CR, Cortopassi G, Datta S, Varner DD, Meyers SA. Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media. Theriogenology. 2016 Sep 15; 86(5):1382-92. PMID: 27242178.
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    21. Hayashi G, Cortopassi G. Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia. PLoS One. 2016; 11(4):e0153574. PMID: 27078885; PMCID: PMC4831832.
    22. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-85. PMID: 27059956; PMCID: PMC4933453 [Available on 06/10/17].
    23. Shen Y, McMackin MZ, Shan Y, Raetz A, David S, Cortopassi G. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. PLoS One. 2016; 11(3):e0151026. PMID: 26954031; PMCID: PMC4783034.
    24. Shan Y, Cortopassi G. Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. Mitochondrion. 2016 Jan; 26:94-103. PMID: 26702583.
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    25. Hayashi G, Cortopassi G. Oxidative stress in inherited mitochondrial diseases. Free Radic Biol Med. 2015 Nov; 88(Pt A):10-7. PMID: 26073122.
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    26. Hagopian K, Tomilov AA, Kim K, Cortopassi G, Ramsey JJ. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. PMID: 25880638; PMCID: PMC4400099.
    27. Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi G, Erickson JD, Maezawa I. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci. 2015 Feb 11; 35(6):2516-29. PMID: 25673846; PMCID: PMC4323531.
    28. Yu AK, Song L, Murray KD, van der List D, Sun C, Shen Y, Xia Z, Cortopassi G. Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum Mol Genet. 2015 May 15; 24(10):2848-60. PMID: 25652399; PMCID: PMC4406296.
    29. Song L, Cortopassi G. Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. 2015 Jan 12; 1594:82-91. PMID: 25446449.
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    30. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. PMID: 25257068; PMCID: PMC4244234.
    31. Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi G. Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6848-62. PMID: 25113747; PMCID: PMC4245046.
    32. Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014 Dec 20; 23(25):6838-47. PMID: 25104852; PMCID: PMC4245045.
    33. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. PMID: 25034306; PMCID: PMC4142054.
    34. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi G, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. PMID: 24336818; PMCID: PMC4172037.
    35. Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi G. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model. Antioxid Redox Signal. 2013 Nov 01; 19(13):1481-93. PMID: 23350650; PMCID: PMC3797453.
    36. Fash DM, Khdour OM, Sahdeo SJ, Goldschmidt R, Jaruvangsanti J, Dey S, Arce PM, Collin VC, Cortopassi G, Hecht SM. Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection. Bioorg Med Chem. 2013 Apr 15; 21(8):2346-2354. PMID: 23473946.
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    37. Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem. 2013 Mar 01; 434(1):105-11. PMID: 23219563; PMCID: PMC3557602.
    38. Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. J Am Heart Assoc. 2012 Oct; 1(5):e003012. PMID: 23316298; PMCID: PMC3541627.
    39. Song L, Shan Y, Lloyd KC, Cortopassi G. Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. 2012 Dec 01; 21(23):5147-58. PMID: 22949510; PMCID: PMC3607469.
    40. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi G, McDonald RB, Ramsey JJ. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. PMID: 22683097; PMCID: PMC3442136.
    41. Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69. PMID: 22619361; PMCID: PMC3380313.
    42. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012 Feb; 11(1):162-8. PMID: 22081964.
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    43. Shan Y, Cortopassi G. HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis. Hum Mol Genet. 2012 Apr 01; 21(7):1457-69. PMID: 22171070; PMCID: PMC3298274.
    44. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi G. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. PMID: 21040401; PMCID: PMC4157392.
    45. Duveau DY, Arce PM, Schoenfeld RA, Raghav N, Cortopassi G, Hecht SM. Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorg Med Chem. 2010 Sep 01; 18(17):6429-41. PMID: 20691600; PMCID: PMC3818132.
    46. Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G. Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion. 2010 Mar; 10(2):143-50. PMID: 20005986; PMCID: PMC3119038.
    47. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi G. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. PMID: 19892704; PMCID: PMC2801244.
    48. Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi G, Rucker RB. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 01; 285(1):142-52. PMID: 19861415; PMCID: PMC2804159.
    49. Lu C, Schoenfeld R, Shan Y, Tsai HJ, Hammock B, Cortopassi G. Frataxin deficiency induces Schwann cell inflammation and death. Biochim Biophys Acta. 2009 Nov; 1792(11):1052-61. PMID: 19679182; PMCID: PMC3563672.
    50. Silva JM, Wong A, Carelli V, Cortopassi G. Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol Dis. 2009 May; 34(2):357-65. PMID: 19233273.
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    51. Rolo AP, Palmeira CM, Cortopassi G. Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 2009 Feb 01; 385(1):176-8. PMID: 18950600; PMCID: PMC2656379.
    52. Kakhlon O, Manning H, Breuer W, Melamed-Book N, Lu C, Cortopassi G, Munnich A, Cabantchik ZI. Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation. Blood. 2008 Dec 15; 112(13):5219-27. PMID: 18796625.
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    53. Prigione A, Cortopassi G. Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins. Aging Cell. 2007 Oct; 6(5):619-30. PMID: 17651460.
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    54. Prigione A, Cortopassi G. Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12. Autophagy. 2007 Jul-Aug; 3(4):377-80. PMID: 17457038.
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    55. Napoli E, Morin D, Bernhardt R, Buckpitt A, Cortopassi G. Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells. Biochim Biophys Acta. 2007 Jul; 1772(7):773-80. PMID: 17499976.
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    56. Shan Y, Napoli E, Cortopassi G. Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones. Hum Mol Genet. 2007 Apr 15; 16(8):929-41. PMID: 17331979.
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    57. Lu C, Cortopassi G. Frataxin knockdown causes loss of cytoplasmic iron-sulfur cluster functions, redox alterations and induction of heme transcripts. Arch Biochem Biophys. 2007 Jan 01; 457(1):111-22. PMID: 17098208; PMCID: PMC1847786.
    58. Alemi M, Prigione A, Wong A, Schoenfeld R, DiMauro S, Hirano M, Taroni F, Cortopassi G. Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med. 2007 Jan 01; 42(1):32-43. PMID: 17157191; PMCID: PMC1927835.
    59. Cortopassi G, Danielson S, Alemi M, Zhan SS, Tong W, Carelli V, Martinuzzi A, Marzuki S, Majamaa K, Wong A. Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts. Mitochondrion. 2006 Aug; 6(4):161-75. PMID: 16815102.
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    60. Napoli E, Taroni F, Cortopassi G. Frataxin, iron-sulfur clusters, heme, ROS, and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):506-16. PMID: 16677095; PMCID: PMC1805116.
    61. Schoenfeld RA, Napoli E, Wong A, Zhan S, Reutenauer L, Morin D, Buckpitt AR, Taroni F, Lonnerdal B, Ristow M, Puccio H, Cortopassi G. Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15; 14(24):3787-99. PMID: 16239244.
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    62. Danielson SR, Carelli V, Tan G, Martinuzzi A, Schapira AH, Savontaus ML, Cortopassi G. Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process. Brain. 2005 May; 128(Pt 5):1026-37. PMID: 15728653.
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    63. Tan G, Napoli E, Taroni F, Cortopassi G. Decreased expression of genes involved in sulfur amino acid metabolism in frataxin-deficient cells. Hum Mol Genet. 2003 Jul 15; 12(14):1699-711. PMID: 12837693.
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    64. Wong A, Cortopassi G. High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader. Biochem Biophys Res Commun. 2002 Nov 15; 298(5):750-4. PMID: 12419317.
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    65. Cortopassi G. A neutral theory predicts multigenic aging and increased concentrations of deleterious mutations on the mitochondrial and Y chromosomes. Free Radic Biol Med. 2002 Sep 01; 33(5):605-10. PMID: 12208346.
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    66. Cortopassi G. Fixation of deleterious alleles, evolution and human aging. Mech Ageing Dev. 2002 Apr 30; 123(8):851-5. PMID: 12044933.
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    67. Wong A, Cavelier L, Collins-Schramm HE, Seldin MF, McGrogan M, Savontaus ML, Cortopassi G. Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells. Hum Mol Genet. 2002 Feb 15; 11(4):431-8. PMID: 11854175.
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    68. Wong A, Cortopassi G. Reproducible quantitative PCR of mitochondrial and nuclear DNA copy number using the LightCycler. Methods Mol Biol. 2002; 197:129-37. PMID: 12013791.
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    69. Danielson SR, Wong A, Carelli V, Martinuzzi A, Schapira AH, Cortopassi G. Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis. J Biol Chem. 2002 Feb 22; 277(8):5810-5. PMID: 11741983.
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