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Heather Knych

TitleAssistant Professor
InstitutionUniversity of California Davis
DepartmentEquine Analytical Chemistry Program
AddressK.L. Maddy Equine Analytical Chemistry Laboratory
CA 95616
Phone530-752-8700
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Houck EL, Guzman DS, Beaufrère H, Knych HK, Paul-Murphy JR. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 79(8):820-827. PMID: 30058846.
      View in: PubMed
    2. Knych HK, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D. L- and D-threo Ethylphenidate Concentrations, Pharmacokinetics and Pharmacodynamics in Horses. Drug Test Anal. 2018 May 22. PMID: 29786965.
      View in: PubMed
    3. Knych HK, Seminoff K, McKemie DS. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Test Anal. 2018 Mar 25. PMID: 29575649.
      View in: PubMed
    4. Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 Mar 23. PMID: 29572958.
      View in: PubMed
    5. Sadar MJ, Knych HK, Drazenovich TL, Paul-Murphy JR. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar; 79(3):260-266. PMID: 29466036.
      View in: PubMed
    6. Kilcoyne I, Nieto JE, Knych HK, Dechant JE. Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses. Am J Vet Res. 2018 Mar; 79(3):282-286. PMID: 29466037.
      View in: PubMed
    7. Garg N, Hansson A, Knych HK, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018 Jan 31; 16(5):698-702. PMID: 29319101.
      View in: PubMed
    8. Gleeson MD, Guzman DS, Knych HK, Kass PH, Drazenovich TL, Hawkins MG. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan; 79(1):13-20. PMID: 29287158.
      View in: PubMed
    9. Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M. Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 01; 1074-1075:91-98. PMID: 29334634.
      View in: PubMed
    10. Knych HK, Mama KR, Steffey EP, Stanley SD, Kass PH. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. Am J Vet Res. 2017 Oct; 78(10):1182-1192. PMID: 28945130.
      View in: PubMed
    11. Smith CK, Seddighi R, Cox SK, Sun X, Knych HK, Doherty TJ. Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs. Vet Anaesth Analg. 2017 Nov; 44(6):1287-1295. PMID: 29074303.
      View in: PubMed
    12. Knych HK, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH. Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1392-1399. PMID: 28513092.
      View in: PubMed
    13. Salyards GW, Lemoy MJ, Knych HK, Hill AE, Christe KL. Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2017 Jul 01; 56(4):443-451. PMID: 28724494.
      View in: PubMed
    14. Laniesse D, Smith DA, Knych HK, Mosley C, Guzman DS, Beaufrère H. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun; 78(6):677-687. PMID: 28541144.
      View in: PubMed
    15. Laniesse D, Guzman DS, Knych HK, Smith DA, Mosley C, Paul-Murphy JR, Beaufrère H. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2017 Jun; 78(6):688-694. PMID: 28541145.
      View in: PubMed
    16. Guzman DS, Knych HK, Olsen GH, Paul-Murphy JR. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun; 31(2):102-107. PMID: 28644085.
      View in: PubMed
    17. Barnett SE, Sellon DC, Hines MT, Seino KK, Knych HK. Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream. Am J Vet Res. 2017 Apr; 78(4):405-411. PMID: 28346003.
      View in: PubMed
    18. Knych HK, Stanley SD, Harrison LM, Mckemie DS. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1385-1391. PMID: 28117560.
      View in: PubMed
    19. Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul; 44(4):755-765. PMID: 28734855.
      View in: PubMed
    20. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. PMID: 27426730.
      View in: PubMed
    21. Knych HK. Nonsteroidal Anti-inflammatory Drug Use in Horses. Vet Clin North Am Equine Pract. 2017 Apr; 33(1):1-15. PMID: 28190614.
      View in: PubMed
    22. Corado CR, McKemie DS, Knych HK. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun; 9(6):880-887. PMID: 27580591.
      View in: PubMed
    23. Knych HK, Stanley SD, McKemie DS, Arthur RM, Kass PH. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses. Drug Test Anal. 2017 May; 9(5):713-720. PMID: 27492623.
      View in: PubMed
    24. Corado CR, McKemie DS, Knych HK. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep; 77(9):1029-35. PMID: 27580115.
      View in: PubMed
    25. Knych HK, Harrison LM, Steinmetz SJ, Chouicha N, Kass PH. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. BMC Genomics. 2016 08 09; 17:596. PMID: 27506674; PMCID: PMC4979108.
    26. Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug; 77(8):833-45. PMID: 27463546.
      View in: PubMed
    27. Waugh L, Knych H, Cole G, D'Agostino J. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). J Zoo Wildl Med. 2016 Jun; 47(2):468-73. PMID: 27468018.
      View in: PubMed
    28. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016 Apr 15; 30(7):833-42. PMID: 26969924.
      View in: PubMed
    29. Messenger KM, Hopfensperger M, Knych HK, Papich MG. Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs. Am J Vet Res. 2016 Apr; 77(4):413-20. PMID: 27027842.
      View in: PubMed
    30. Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych HK, Scharf AM, Quandt JE. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb; 77(2):119-26. PMID: 27027704.
      View in: PubMed
    31. Knych HK, Arthur RM, Steinmetz S, McKemie DS. Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. Vet J. 2016 Jan; 207:196-8. PMID: 27152386.
      View in: PubMed
    32. Salyards GW, Knych HK, Hill AE, Kelly KR, Christe KL. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration. J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):557-63. PMID: 26424255; PMCID: PMC4587625.
    33. Knych HK, Harrison LM, White A, McKemie DS. Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. 2016 Jan; 8(1):141-7. PMID: 26333097.
      View in: PubMed
    34. Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2016 Jan; 43(1):35-43. PMID: 25943714.
      View in: PubMed
    35. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes. Drug Test Anal. 2015 Aug; 7(8):673-83. PMID: 25560998.
      View in: PubMed
    36. Gustavsen KA, Guzman DS, Knych HK, Petritz OA, Olsen GH, Paul-Murphy JR. Pharmacokinetics of buprenorphine hydrochloride following intramuscular and intravenous administration to American kestrels (Falco sparverius). Am J Vet Res. 2014 Aug; 75(8):711-5. PMID: 25061701.
      View in: PubMed
    37. Knych HK, Stanley SD. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Vet Anaesth Analg. 2014 Jan; 41(1):36-47. PMID: 24134603.
      View in: PubMed
    38. Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR. Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Am J Vet Res. 2013 Apr; 74(4):550-6. PMID: 23531062.
      View in: PubMed
    39. Knych HK, Corado CR, McKemie DS, Steffey EP. Pharmacokinetics and selected pharmacodynamic effects of tramadol following intravenous administration to the horse. Equine Vet J. 2013 Jul; 45(4):490-6. PMID: 23145962.
      View in: PubMed
    40. DiMaio Knych HK, Covarrubias V, Steffey EP. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Vet Anaesth Analg. 2012 Nov; 39(6):574-83. PMID: 23035904.
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    41. Knych HK, Corado CR, McKemie DS, Scholtz E, Sams R. Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. J Vet Pharmacol Ther. 2013 Aug; 36(4):389-98. PMID: 23061925.
      View in: PubMed
    42. Knych HK, Steffey EP, Stanley SD. The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse. Vet Anaesth Analg. 2012 May; 39(3):221-9. PMID: 22405129.
      View in: PubMed
    43. Knych HK, Casbeer HC, McKemie DS, Arthur RM. Pharmacokinetics and pharmacodynamics of butorphanol following intravenous administration to the horse. J Vet Pharmacol Ther. 2013 Feb; 36(1):21-30. PMID: 22339417.
      View in: PubMed
    44. Dimaio Knych HK, Stanley SD. Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses. Am J Vet Res. 2011 Oct; 72(10):1378-85. PMID: 21962281.
      View in: PubMed
    45. Pavez JC, Hawkins MG, Pascoe PJ, Knych HK, Kass PH. Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis). Vet Anaesth Analg. 2011 Jul; 38(4):344-51. PMID: 21672126.
      View in: PubMed
    46. DiMaio Knych HK, Arthur RM, Taylor A, Moeller BC, Stanley SD. Pharmacokinetics and metabolism of dantrolene in horses. J Vet Pharmacol Ther. 2011 Jun; 34(3):238-46. PMID: 21492188.
      View in: PubMed
    47. Dimaio Knych HK, Steffey EP, Deuel JL, Shepard RA, Stanley SD. Pharmacokinetics of yohimbine following intravenous administration to horses. J Vet Pharmacol Ther. 2011 Feb; 34(1):58-63. PMID: 21219345.
      View in: PubMed
    48. Dimaio Knych HK, Steffey EP, Stanley SD. Pharmacokinetics and pharmacodynamics of three intravenous doses of yohimbine in the horse. J Vet Pharmacol Ther. 2011 Aug; 34(4):359-66. PMID: 20950351.
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    49. Knych HK, McKemie DS, Stanley SD. Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses. Drug Metab Dispos. 2010 Oct; 38(10):1820-7. PMID: 20587621.
      View in: PubMed
    50. Knych HK, Steffey EP, Mama KR, Stanley SD. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. Am J Vet Res. 2009 Oct; 70(10):1193-200. PMID: 19795933.
      View in: PubMed
    51. DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD. Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009 May 01; 485(1):49-55. PMID: 19245785.
      View in: PubMed
    52. DiMaio Knych HK, Stanley SD. Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol. 2008 Oct 01; 76(7):904-11. PMID: 18692486.
      View in: PubMed