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Heather K Knych, PhD; DVM

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
AddressK.L. Maddy Equine Analytical Chemistry Laboratory
CA 95616
Phone530-752-8700
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    1. Identification and characterization of the enzymes responsible for the metabolism of the non-steroidal anti-inflammatory drugs, flunixin meglumine and phenylbutazone, in horses. J Vet Pharmacol Ther. 2020 Aug 05. Knych HK, Finno CJ, Baden R, Arthur RM, McKemie DS. PMID: 32757313.
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    2. Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica). Am J Vet Res. 2020 Aug; 81(8):651-655. Berg KJ, Sanchez-Migallon Guzman D, Knych HK, Drazenovich TL, Paul-Murphy JR. PMID: 32700994.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves. Am J Vet Res. 2020 Aug; 81(8):673-680. Gamsjäger L, Vander Ley BL, Knych HK, McArthur GR, Heller MC. PMID: 32700995.
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    4. Sedative effects and pharmacokinetics of detomidine when administered intravenously and intravaginally as a gel in alpacas. Vet Anaesth Analg. 2020 Jul 27. Chow NS, Seddighi R, Knych HK, Sun X, Doherty TJ. PMID: 32863105.
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    5. Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats. J Feline Med Surg. 2020 Jul 09; 1098612X20917305. Smith P, Tolbert MK, Gould E, Taylor A, Knych H, Messenger K. PMID: 32643979.
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    6. Serum concentrations, pharmacokinetic/pharmacodynamic modeling, and effects of dexamethasone on inflammatory mediators following intravenous and oral administration to exercised horses. Drug Test Anal. 2020 Aug; 12(8):1087-1101. Knych HK, Weiner D, Arthur RM, Baden R, McKemie DS, Kass PH. PMID: 32436346.
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    7. Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high-intensity treadmill training. J Vet Pharmacol Ther. 2020 Jun 01. Knych HK, Wilson WD, Vale A, Kass PH, Steffey EP, Jones JH, Arthur RM. PMID: 32483865.
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    8. Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses. Vet Anaesth Analg. 2020 Apr 23. Gretler SR, Finno CJ, McKemie DS, Kass PH, Knych HK. PMID: 32654915.
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    9. Pharmacokinetics of hydromorphone hydrochloride after intravenous and intramuscular administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2020 Apr; 81(4):361-366. Ambros B, Knych HK, Sadar MJ. PMID: 32228262.
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    10. Evaluation of Orally Administered Atorvastatin on Plasma Lipid and Biochemistry Profiles in Hypercholesterolemic Hispaniolan Amazon Parrots (Amazona ventralis). J Avian Med Surg. 2020 Mar 29; 34(1):32-40. Robertson JA, Guzman DS, Graham JL, Stanhope KL, Douglas JM, Havel PJ, Beaufrère H, Knych H, Tully TN, Paul-Murphy JR. PMID: 32237680.
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    11. Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia. J Vet Pharmacol Ther. 2020 Jul; 43(4):369-376. Guedes A, Knych H, Tucker L, Almeida DC, Baldo CF, Wendt-Hornickle E, Allweiler S. PMID: 32166760.
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    12. Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses. Equine Vet J. 2020 Mar 07. Knych HK, Arthur RM, McKemie DS, Baden RW, Seminoff K, Kass PH. PMID: 32145701.
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    13. Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats. Front Vet Sci. 2020; 7:86. Yates LM, Aleman M, Knych HK, Knipe MF, Crowe CM, Chigerwe M. PMID: 32154280.
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    14. Pharmacokinetics and pharmacodynamics of clodronate disodium evaluated in plasma, synovial fluid and urine. Equine Vet J. 2020 Sep; 52(5):725-732. Krueger CR, Mitchell CF, Leise BS, Knych HK. PMID: 32003488.
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    15. Pharmacokinetics of maropitant citrate after oral administration of multiple doses in adult horses. J Vet Pharmacol Ther. 2020 May; 43(3):282-287. Berryhill EH, Knych H, Chigerwe M, Edman J, Magdesian KG. PMID: 32067245.
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    16. Pharmacokinetics and pharmacodynamics of hydromorphone after intravenous and intramuscular administration in horses. Vet Anaesth Analg. 2020 Mar; 47(2):210-218. Reed RA, Knych HK, Barletta M, Sakai DM, Ruch MM, Smyth CA, Ryan CA. PMID: 31959534.
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    17. Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2019 Oct; 80(10):963-968. Ozawa SM, Hawkins MG, Drazenovich TL, Kass PH, Knych HK. PMID: 31556710.
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    18. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2019 Nov; 42(6):617-623. Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS. PMID: 31490561.
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    19. Concentrations of medetomidine enantiomers and vatinoxan, an a2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. Vet Anaesth Analg. 2020 Jan; 47(1):47-52. Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM. PMID: 31761600.
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    20. Detection, pharmacokinetics, and selected pharmacodynamic effects of methamphetamine following a single transmucosal and intravenous administration to exercised Thoroughbred horses. Drug Test Anal. 2019 Sep; 11(9):1431-1443. Knych HK, Arthur RM, Kanarr KL, McKemie DS, Kass PH. PMID: 31218824.
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    21. Characterization of the in vitro CYP450 mediated metabolism of the polymorphic CYP2D6 probe drug codeine in horses. Biochem Pharmacol. 2019 10; 168:184-192. Knych HK, Baden RW, Gretler SR, McKemie DS. PMID: 31295464.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Pharmacokinetics of a Long-lasting, Highly Concentrated Buprenorphine Solution after Subcutaneous Administration in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2019 07 01; 58(4):501-509. Mackiewicz AL, Salyards GW, Knych HK, Hill AE, Christe KL. PMID: 31227029.
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    23. Evaluation of the sedative effects and pharmacokinetics of detomidine gel administered intravaginally to horses. Vet Anaesth Analg. 2019 Nov; 46(6):772-779. Seddighi R, Knych HK, Cox SK, Sun X, Moorhead KA, Doherty TJ. PMID: 31474339.
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    24. Pharmacokinetics of single doses of maropitant citrate in adult horses. J Vet Pharmacol Ther. 2019 Jul; 42(4):487-491. Berryhill EH, Knych H, Edman JM, Magdesian KG. PMID: 31190332.
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    25. Pharmacokinetics of chloramphenicol base in horses and comparison to compounded formulations. J Vet Pharmacol Ther. 2019 Nov; 42(6):609-616. Patel T, Magdesian KG, Estell KE, Edman JM, Knych HK. PMID: 31162675.
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    26. Pharmacokinetics and competitive pharmacodynamics of ADP-induced platelet activation after oral administration of clopidogrel to horses. Am J Vet Res. 2019 May; 80(5):505-512. Norris JW, Watson JL, Tablin F, Kozikowski TA, Knych HK. PMID: 31034271.
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    27. Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses. J Vet Pharmacol Ther. 2019 Jul; 42(4):401-410. Hamamoto-Hardman BD, Steffey EP, Weiner D, McKemie DS, Kass P, Knych HK. PMID: 30919469.
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    28. Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses. Drug Test Anal. 2019 Jun; 11(6):792-803. Knych HK, Arthur RM, McKemie DS, Seminoff K, Hamamoto-Hardman B, Kass PH. PMID: 30499176.
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    29. Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Dec; 79(12):1239-1245. Guzman DS, Houck EL, Knych HKD, Beaufrère H, Paul-Murphy JR. PMID: 30457903.
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    30. The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses. Vet Anaesth Analg. 2019 May; 46(3):395-404. Reed R, Barletta M, Mitchell K, Hanafi A, Bullington A, Knych H, Quandt J, Ryan C, Giguère S. PMID: 30930095.
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    31. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019; 103(1-2):10-16. Cenani A, Brosnan RJ, Knych HK. PMID: 30332672.
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    32. Plasma and synovial fluid concentrations and cartilage toxicity of bupivacaine following intra-articular administration of a liposomal formulation to horses. Equine Vet J. 2019 May; 51(3):408-414. Knych HK, Mama KR, Moore CE, Hill AE, McKEMIE DS. PMID: 30182426.
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    33. Pharmacokinetics of intravenous flumetasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse. Equine Vet J. 2019 Mar; 51(2):238-245. Knych HK, Arthur RM, McKemie DS, Baden R, Oldberg N, Kass PH. PMID: 30080272.
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    34. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 79(8):820-827. Houck EL, Guzman DS, Beaufrère H, Knych HK, Paul-Murphy JR. PMID: 30058846.
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    35. 5a-dihydroprogesterone concentrations and synthesis in non-pregnant mares. J Endocrinol. 2018 07; 238(1):25-32. Conley AJ, Scholtz EL, Legacki EL, Corbin CJ, Knych HK, Dujovne GD, Ball BA, Moeller BC, Stanley SD. PMID: 29853526.
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    36. L- and D-threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses. Drug Test Anal. 2018 Oct; 10(10):1508-1517. Knych HK, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D. PMID: 29786965.
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    37. Pharmacokinetics of fentanyl after intravenous administration in isoflurane-anesthetized red-tailed hawks (Buteo jamaicensis) and Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):606-613. Pascoe PJ, Pypendop BH, Pavez Phillips JC, DiMaio Knych HK, Sanchez-Migallon Guzman D, Hawkins MG. PMID: 30085853.
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    38. Effects of three fentanyl plasma concentrations on the minimum alveolar concentration of isoflurane in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):600-605. Hawkins MG, Pascoe PJ, DiMaio Knych HK, Drazenovich TL, Kass PH, Sanchez-Migallon Guzman D. PMID: 30085862.
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    39. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Test Anal. 2018 Mar 25. Knych HK, Seminoff K, McKemie DS. PMID: 29575649.
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    40. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 May; 32(3):1283-1289. Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. PMID: 29572958.
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    41. Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses. Am J Vet Res. 2018 Mar; 79(3):282-286. Kilcoyne I, Nieto JE, Knych HK, Dechant JE. PMID: 29466037.
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    42. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar; 79(3):260-266. Sadar MJ, Knych HK, Drazenovich TL, Paul-Murphy JR. PMID: 29466036.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    43. Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2018 Aug; 41(4):522-535. Knych HK, Seminoff K, McKemie DS, Kass PH. PMID: 29457257.
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    44. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018 01 31; 16(5):698-702. Garg N, Hansson A, Knych HK, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D. PMID: 29319101.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    45. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan; 79(1):13-20. Gleeson MD, Guzman DS, Knych HK, Kass PH, Drazenovich TL, Hawkins MG. PMID: 29287158.
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    46. Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 01; 1074-1075:91-98. Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M. PMID: 29334634.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    47. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Vet J. 2018 Jul; 50(4):504-512. Knych HK, Harrison L, Chouicha N, Kass PH. PMID: 29044706.
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    48. Effectiveness of furosemide in attenuating exercise-induced pulmonary haemorrhage in horses when administered at 4- and 24-h prior to high-speed training. Equine Vet J. 2018 May; 50(3):350-355. Knych HK, Wilson WD, Vale A, Kass PH, Arthur RM, Jones JH. PMID: 28963734.
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    49. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2018 Apr; 41(2):230-238. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. PMID: 29067696.
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    50. Pharmacokinetics of furosemide administered 4 and 24 hours prior to high-speed exercise in horses. J Vet Pharmacol Ther. 2018 Apr; 41(2):224-229. Knych HK, Vale A, Wilson WD, Kass PH, Arthur RM, Jones JH. PMID: 29057472.
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    51. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. Am J Vet Res. 2017 Oct; 78(10):1182-1192. Knych HK, Mama KR, Steffey EP, Stanley SD, Kass PH. PMID: 28945130.
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    52. Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs. Vet Anaesth Analg. 2017 Nov; 44(6):1287-1295. Smith CK, Seddighi R, Cox SK, Sun X, Knych HK, Doherty TJ. PMID: 29074303.
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    53. Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1392-1399. Knych HK, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH. PMID: 28513092.
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    54. Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2017 Jul 01; 56(4):443-451. Salyards GW, Lemoy MJ, Knych HK, Hill AE, Christe KL. PMID: 28724494.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    55. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun; 31(2):102-107. Guzman DS, Knych HK, Olsen GH, Paul-Murphy JR. PMID: 28644085.
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    56. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun; 78(6):677-687. Laniesse D, Smith DA, Knych HK, Mosley C, Guzman DS, Beaufrère H. PMID: 28541144.
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    57. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2017 Jun; 78(6):688-694. Laniesse D, Guzman DS, Knych HK, Smith DA, Mosley C, Paul-Murphy JR, Beaufrère H. PMID: 28541145.
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    58. Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream. Am J Vet Res. 2017 Apr; 78(4):405-411. Barnett SE, Sellon DC, Hines MT, Seino KK, Knych HK. PMID: 28346003.
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    59. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1385-1391. Knych HK, Stanley SD, Harrison LM, Mckemie DS. PMID: 28117560.
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    60. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul; 44(4):755-765. Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. PMID: 28734855.
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    61. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. PMID: 27426730.
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    62. Nonsteroidal Anti-inflammatory Drug Use in Horses. Vet Clin North Am Equine Pract. 2017 Apr; 33(1):1-15. Knych HK. PMID: 28190614.
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    63. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide. Vet Comp Oncol. 2017 Dec; 15(4):1558-1563. Burton JH, Knych HK, Stanley SD, Rebhun RB. PMID: 28120478.
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    64. Pharmacokinetics and selected pharmacodynamics of romifidine following low-dose intravenous administration in combination with exercise to quarter horses. J Vet Pharmacol Ther. 2017 Oct; 40(5):569-574. Knych HK, Stanley SD, McKemie DS, Steinmetz SJ. PMID: 28097665.
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    65. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun; 9(6):880-887. Corado CR, McKemie DS, Knych HK. PMID: 27580591.
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    66. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses. Drug Test Anal. 2017 May; 9(5):713-720. Knych HK, Stanley SD, McKemie DS, Arthur RM, Kass PH. PMID: 27492623.
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    67. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep; 77(9):1029-35. Corado CR, McKemie DS, Knych HK. PMID: 27580115.
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    68. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. BMC Genomics. 2016 08 09; 17:596. Knych HK, Harrison LM, Steinmetz SJ, Chouicha N, Kass PH. PMID: 27506674.
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    69. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug; 77(8):833-45. Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. PMID: 27463546.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    70. Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses. J Vet Intern Med. 2016 Jul; 30(4):1322-6. Aleman M, Davis E, Knych H, Guedes A, Smith F, Madigan JE. PMID: 27362367.
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    71. Pharmacokinetic and pharmacodynamic properties of pergolide mesylate following long-term administration to horses with pituitary pars intermedia dysfunction. J Vet Pharmacol Ther. 2017 Apr; 40(2):158-164. McFarlane D, Banse H, Knych HK, Maxwell LK. PMID: 27301465.
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    72. Disposition of the anti-ulcer medications ranitidine, cimetidine, and omeprazole following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2017 Jan; 40(1):92-96. Knych HK, Stanley SD, Arthur RM, McKemie DS. PMID: 27292271.
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    73. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). J Zoo Wildl Med. 2016 Jun; 47(2):468-73. Waugh L, Knych H, Cole G, D'Agostino J. PMID: 27468018.
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    74. Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):522-4. Knych HK, Stanley SD, Arthur RM, McKemie DS. PMID: 27121892.
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    75. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016 Apr 15; 30(7):833-42. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. PMID: 26969924.
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    76. Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs. Am J Vet Res. 2016 Apr; 77(4):413-20. Messenger KM, Hopfensperger M, Knych HK, Papich MG. PMID: 27027842.
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    77. Pharmacokinetics of methocarbamol and phenylbutazone in exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):469-77. Knych HK, Stanley SD, Seminoff KN, McKemie DS, Kass PH. PMID: 26924025.
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    78. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb; 77(2):119-26. Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych HK, Scharf AM, Quandt JE. PMID: 27027704.
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    79. Pharmacokinetics of guaifenesin following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Aug; 39(4):416-9. Knych HK, Stanley SD, Benson D, Arthur RM. PMID: 26763117.
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    80. Serum, milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation. J Vet Pharmacol Ther. 2016 Aug; 39(4):363-72. Puschner B, Bautista AC, McKemie DS, Gallego SM, Woods LW, Moore CE, Knych HK. PMID: 26763112.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    81. Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra-articular administration of triamcinolone acetonide in exercised horses. Equine Vet J. 2017 Jan; 49(1):107-115. Knych HK, Vidal MA, Chouicha N, Mitchell M, Kass PH. PMID: 26518341.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    82. Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals. Equine Vet J. 2016 Jan; 48(1):65-71. Knych HK, Steffey EP, White AM, McKemie DS. PMID: 27030842.
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    83. Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. Vet J. 2016 Jan; 207:196-8. Knych HK, Arthur RM, Steinmetz S, McKemie DS. PMID: 27152386.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    84. Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. J Vet Intern Med. 2016 Jan-Feb; 30(1):242-6. Burton JH, Stanley SD, Knych HK, Rodriguez CO, Skorupski KA, Rebhun RB. PMID: 26682700.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    85. Evidence for polymorphism in the cytochrome P450 2D50 gene in horses. J Vet Pharmacol Ther. 2016 Jun; 39(3):245-54. Corado CR, McKemie DS, Young A, Knych HK. PMID: 26441153.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    86. Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. 2016 Jan; 8(1):141-7. Knych HK, Harrison LM, White A, McKemie DS. PMID: 26333097.
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    87. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration. J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):557-63. Salyards GW, Knych HK, Hill AE, Kelly KR, Christe KL. PMID: 26424255.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    88. Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol. Equine Vet J. 2016 Jul; 48(4):528-31. Guedes A, Knych H, Hood D. PMID: 25832551.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    89. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2016 Jan; 43(1):35-43. Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. PMID: 25943714.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    90. Pharmacokinetics of a single subcutaneous dose of sustained release buprenorphine in northern elephant seals (Mirounga angustirostris). J Zoo Wildl Med. 2015 Mar; 46(1):52-61. Molter CM, Barbosa L, Johnson S, Knych HK, Chinnadurai SK, Wack RF. PMID: 25831576.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    91. Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses. J Vet Pharmacol Ther. 2015 Aug; 38(4):313-20. Knych HK, Arthur RM, McKemie DS, Chapman N. PMID: 25582761.
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    92. Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes. Drug Test Anal. 2015 Aug; 7(8):673-83. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. PMID: 25560998.
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    93. Chapter 13 Analgesic Pharmacology. . 2015 Jan 1; (Vet Anaesth Analg362009):55-57. Heather K. Knych. .
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    94. Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals. Equine Vet J. 2015 01; 47(1):72-7. Knych HK, Steffey EP, Mitchell MM, Casbeer HC. PMID: 25263971.
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    95. Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses. Drug Test Anal. 2015 Jul; 7(7):619-25. Knych HK, Arthur RM, Mitchell MM, Holser I, Poppenga R, Smith LL, Helm MN, Sams RA, Gaskill CL. PMID: 25327415.
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    96. Pharmacokinetics of metronidazole in foals: influence of age within the neonatal period. J Vet Pharmacol Ther. 2015 Jun; 38(3):227-34. Swain EA, Magdesian KG, Kass PH, Edman JE, Knych HK. PMID: 25271172.
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    97. Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals. Equine Vet J. 2015 Sep; 47(5):592-8. Knych HK, Steffey EP, Casbeer HC, Mitchell MM. PMID: 24978306.
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    98. Disposition and metabolic profile of the weak androgen Dehydroepiandrosterone (DHEA) following administration as part of a nutritional supplement to exercised horses. Drug Test Anal. 2015 Jan; 7(1):39-47. Knych HK, Arthur RM, Stanley SD, McKemie DS. PMID: 25242721.
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    99. Pharmacokinetics of buprenorphine hydrochloride following intramuscular and intravenous administration to American kestrels (Falco sparverius). Am J Vet Res. 2014 Aug; 75(8):711-5. Gustavsen KA, Guzman DS, Knych HK, Petritz OA, Olsen GH, Paul-Murphy JR. PMID: 25061701.
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    100. Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses. J Vet Pharmacol Ther. 2015 Apr; 38(2):113-22. Knych HK, Steinmetz SJ, McKemie DS. PMID: 25131315.
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    101. Preliminary pharmacokinetics of morphine and its major metabolites following intravenous administration of four doses to horses. J Vet Pharmacol Ther. 2014 Aug; 37(4):374-81. Knych HK, Steffey EP, McKemie DS. PMID: 24479785.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    102. Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Vet J. 2014 Nov; 46(6):734-8. Knych HK, Stanley SD, Arthur RM, Mitchell MM. PMID: 24393414.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    103. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2014 Jun; 37(3):269-78. Guedes AG, Knych HK, Soares JH, Brosnan RJ. PMID: 24180699.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    104. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Vet Anaesth Analg. 2014 Jan; 41(1):36-47. Knych HK, Stanley SD. PMID: 24134603.
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    105. Detection, pharmacokinetics and cardiac effects following administration of clenbuterol to exercised horses. Equine Vet J. 2014 May; 46(3):380-5. Knych HK, Mitchell MM, Steinmetz SJ, McKemie DS. PMID: 23773115.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCTClinical Trials
    106. Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. J Vet Pharmacol Ther. 2014 Apr; 37(2):125-32. Knych HK, Harrison LM, Casbeer HC, McKemie DS. PMID: 23876165.
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    107. Pharmacokinetics of triamcinolone acetonide following intramuscular and intra-articular administration to exercised Thoroughbred horses. Equine Vet J. 2013 Nov; 45(6):715-20. Knych HK, Vidal MA, Casbeer HC, McKemie DS. PMID: 23574452.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    108. Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Am J Vet Res. 2013 Apr; 74(4):550-6. Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR. PMID: 23531062.
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    109. Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. Vet J. 2013 Jun; 196(3):504-9. Casbeer HC, Knych HK. PMID: 23321455.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    110. Pharmacokinetics and selected pharmacodynamic effects of tramadol following intravenous administration to the horse. Equine Vet J. 2013 Jul; 45(4):490-6. Knych HK, Corado CR, McKemie DS, Steffey EP. PMID: 23145962.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    111. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Vet Anaesth Analg. 2012 Nov; 39(6):574-83. DiMaio Knych HK, Covarrubias V, Steffey EP. PMID: 23035904.
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    112. Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. J Vet Pharmacol Ther. 2013 Aug; 36(4):389-98. Knych HK, Corado CR, McKemie DS, Scholtz E, Sams R. PMID: 23061925.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    113. The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse. Vet Anaesth Analg. 2012 May; 39(3):221-9. Knych HK, Steffey EP, Stanley SD. PMID: 22405129.
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    114. Pharmacokinetics and pharmacodynamics of butorphanol following intravenous administration to the horse. J Vet Pharmacol Ther. 2013 Feb; 36(1):21-30. Knych HK, Casbeer HC, McKemie DS, Arthur RM. PMID: 22339417.
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    115. Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses. Am J Vet Res. 2011 Oct; 72(10):1378-85. Dimaio Knych HK, Stanley SD. PMID: 21962281.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    116. Distribution of flunixin meglumine and firocoxib into aqueous humor of horses. J Vet Intern Med. 2011 Sep-Oct; 25(5):1127-33. Hilton HG, Magdesian KG, Groth AD, Knych H, Stanley SD, Hollingsworth SR. PMID: 21781166.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    117. Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis). Vet Anaesth Analg. 2011 Jul; 38(4):344-51. Pavez JC, Hawkins MG, Pascoe PJ, Knych HK, Kass PH. PMID: 21672126.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCTClinical Trials
    118. Pharmacokinetics and metabolism of dantrolene in horses. J Vet Pharmacol Ther. 2011 Jun; 34(3):238-46. DiMaio Knych HK, Arthur RM, Taylor A, Moeller BC, Stanley SD. PMID: 21492188.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    119. Pharmacokinetics of yohimbine following intravenous administration to horses. J Vet Pharmacol Ther. 2011 Feb; 34(1):58-63. Dimaio Knych HK, Steffey EP, Deuel JL, Shepard RA, Stanley SD. PMID: 21219345.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    120. Pharmacokinetics and pharmacodynamics of three intravenous doses of yohimbine in the horse. J Vet Pharmacol Ther. 2011 Aug; 34(4):359-66. Dimaio Knych HK, Steffey EP, Stanley SD. PMID: 20950351.
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    121. Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses. Drug Metab Dispos. 2010 Oct; 38(10):1820-7. Knych HK, McKemie DS, Stanley SD. PMID: 20587621.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    122. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. Am J Vet Res. 2009 Oct; 70(10):1193-200. Knych HK, Steffey EP, Mama KR, Stanley SD. PMID: 19795933.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    123. Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009 May 01; 485(1):49-55. DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD. PMID: 19245785.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    124. Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol. 2008 Oct 01; 76(7):904-11. DiMaio Knych HK, Stanley SD. PMID: 18692486.
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