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Heather K Knych

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
AddressK.L. Maddy Equine Analytical Chemistry Laboratory
CA 95616
Phone530-752-8700
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    1. Pharmacokinetics of mycophenolate mofetil following single-dose intravenous and single- and multiple-dose oral administration and clinicopathologic effects of mycophenolate mofetil following long-term oral administration in healthy horses. Am J Vet Res. 2021 Jun; 82(6):502-509. Knych HK, McKemie DS, Kanarr KL, White SD. PMID: 34032479.
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    2. SARCOCYSTOSIS IN A CAPTIVE FLOCK OF THICK-BILLED PARROTS (RHYNCHOPSITTA PACHYRHYNCHA) FROM 2005 TO 2016: MORBIDITY, MORTALITY, DIAGNOSTICS, AND MANAGEMENT STRATEGIES. J Zoo Wildl Med. 2021 Apr; 52(1):206-216. Rivas AE, Conley K, Seimon TA, Hollinger C, Knych H, Moore RP, Paré JA. PMID: 33827178.
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    3. Pharmacokinetics and effects on arachidonic acid metabolism of low doses of cannabidiol following oral administration to horses. Drug Test Anal. 2021 Mar 15. Ryan D, McKemie DS, Kass PH, Puschner B, Knych HK. PMID: 33723919.
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    4. Equine antimicrobial therapy: Current and past issues facing practitioners. J Vet Pharmacol Ther. 2021 Mar; 44(2):270-279. Knych HK, Magdesian KG. PMID: 33650183.
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    5. Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses. J Vet Pharmacol Ther. 2021 Feb 12. Shane SE, Langston VC, Wills RW, Denney WS, Knych H, Fontenot RL, Meyer RE, Natalini CC. PMID: 33576078.
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    6. Preliminary study of the stability of dexamethasone when added to commercial veterinary ear cleaners over a 90 day period. Vet Dermatol. 2021 Feb 02. Emery CB, Outerbridge CA, Knych HK, Lam ATH, Gomez-Vazquez JP, White SD. PMID: 33528860.
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    7. Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control. Metabolites. 2021 Feb 01; 11(2). Broberg MN, Knych H, Bondesson U, Pettersson C, Stanley S, Thevis M, Hedeland M. PMID: 33535528.
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    8. The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses. Equine Vet J. 2021 Jan 16. Skrzypczak H, Reed R, Brainard B, Sakai D, Barletta M, Quandt J, Smyth C, Ruch M, Knych H. PMID: 33453066.
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    9. INTRAVENOUS IOPAMIDOL PHARMACOKINETICS IN COMMON CARP (CYPRINUS CARPIO). J Zoo Wildl Med. 2021 Jan; 51(4):889-895. Kaufman M, Knych H, Brust K, Phillips K, McKemie D, Yun S, Kenelty K, Soto E. PMID: 33480569.
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    10. Effect of Meperidine on Equine Blood Histamine, Tryptase, and Immunoglobulin-E Concentrations. Front Vet Sci. 2020; 7:584922. Trenholme HN, Sakai DM, Berghaus LJ, Hanafi AL, Knych HK, Ryan CA, McHale B, Banovic F, Quandt JE, Barletta M, Reed RA. PMID: 33426016.
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    11. Pharmacokinetics of a Single Dose of Oral Meloxicam in Rehabilitated Wild Brown Pelicans (Pelecanus occidentalis). J Avian Med Surg. 2020 Dec; 34(4):329-337. Horgan MD, Knych HK, Siksay SE, Duerr RS. PMID: 33355409.
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    12. Pharmacokinetics and pharmacodynamics of meperidine after intramuscular and subcutaneous administration in horses. Vet Surg. 2020 Nov 26. Hanafi AL, Reed RA, Trenholme HN, Sakai DM, Ryan CA, Barletta M, Quandt JE, Knych HK. PMID: 33242227.
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    13. Pharmacokinetics of hydromorphone hydrochloride after intramuscular and intravenous administration of a single dose to orange-winged Amazon parrots (Amazona amazonica). Am J Vet Res. 2020 Nov; 81(11):894-898. Sanchez-Migallon Guzman D, Knych H, Douglas J, Paul-Murphy JR. PMID: 33107746.
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    14. Pharmacokinetic and Efficacy Study of Acyclovir Against Cyprinid Herpesvirus 3 in Cyprinus carpio. Front Vet Sci. 2020; 7:587952. Quijano Cardé EM, Yazdi Z, Yun S, Hu R, Knych H, Imai DM, Soto E. PMID: 33195621.
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    15. Drug content on receipt and over time for compounded formulations of famciclovir. J Feline Med Surg. 2020 Oct 06; 1098612X20961046. Johnson LR, Weaver PG, Forsythe LE, Thomasy SM, Knych HK. PMID: 33019848.
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    16. Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses. BMC Vet Res. 2020 Oct 01; 16(1):368. Hamamoto-Hardman BD, Steffey EP, McKemie DS, Kass PH, Knych HK. PMID: 32998730.
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    17. Pharmacokinetics of danofloxacin following intramuscular administration of a single dose in koi (Cyprinus carpio). Am J Vet Res. 2020 Sep; 81(9):708-713. Parker-Graham CA, Siniard WC, Byrne BA, Knych HK, Soto E. PMID: 33112164.
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    18. Identification and characterization of the enzymes responsible for the metabolism of the non-steroidal anti-inflammatory drugs, flunixin meglumine and phenylbutazone, in horses. J Vet Pharmacol Ther. 2021 Jan; 44(1):36-46. Knych HK, Finno CJ, Baden R, Arthur RM, McKemie DS. PMID: 32757313.
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    19. Equine uridine diphospho-glucuronosyltransferase 1A1, 2A1, 2B4, 2B31: cDNA cloning, expression and initial characterization of morphine metabolism. Vet Anaesth Analg. 2020 Nov; 47(6):763-772. Hamamoto-Hardman BD, Baden RW, McKemie DS, Knych HK. PMID: 32933848.
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    20. Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica). Am J Vet Res. 2020 Aug; 81(8):651-655. Berg KJ, Sanchez-Migallon Guzman D, Knych HK, Drazenovich TL, Paul-Murphy JR. PMID: 32700994.
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    21. Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves. Am J Vet Res. 2020 Aug; 81(8):673-680. Gamsjäger L, Vander Ley BL, Knych HK, McArthur GR, Heller MC. PMID: 32700995.
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    22. Sedative effects and pharmacokinetics of detomidine when administered intravenously and intravaginally as a gel in alpacas. Vet Anaesth Analg. 2020 Nov; 47(6):773-780. Chow NS, Seddighi R, Knych HK, Sun X, Doherty TJ. PMID: 32863105.
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    23. Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats. J Feline Med Surg. 2020 Dec; 22(12):1184-1190. Smith P, Tolbert MK, Gould E, Taylor A, Knych H, Messenger K. PMID: 32643979.
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    24. Serum concentrations, pharmacokinetic/pharmacodynamic modeling, and effects of dexamethasone on inflammatory mediators following intravenous and oral administration to exercised horses. Drug Test Anal. 2020 Aug; 12(8):1087-1101. Knych HK, Weiner D, Arthur RM, Baden R, McKemie DS, Kass PH. PMID: 32436346.
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    25. Physiologic effects of furosemide in combination with water restriction when administered at 4 and 24 hours prior to high-intensity treadmill training. J Vet Pharmacol Ther. 2020 Nov; 43(6):565-576. Knych HK, Wilson WD, Vale A, Kass PH, Steffey EP, Jones JH, Arthur RM. PMID: 32483865.
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    26. Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses. Vet Anaesth Analg. 2020 Sep; 47(5):694-704. Gretler SR, Finno CJ, McKemie DS, Kass PH, Knych HK. PMID: 32654915.
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    27. Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses. Equine Vet J. 2021 Jan; 53(1):102-116. Knych HK, Arthur RM, McKemie DS, Baden RW, Seminoff K, Kass PH. PMID: 32145701.
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    28. Pharmacokinetics of hydromorphone hydrochloride after intravenous and intramuscular administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2020 Apr; 81(4):361-366. Ambros B, Knych HK, Sadar MJ. PMID: 32228262.
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    29. Evaluation of Orally Administered Atorvastatin on Plasma Lipid and Biochemistry Profiles in Hypercholesterolemic Hispaniolan Amazon Parrots (Amazona ventralis). J Avian Med Surg. 2020 Mar 29; 34(1):32-40. Robertson JA, Guzman DS, Graham JL, Stanhope KL, Douglas JM, Havel PJ, Beaufrère H, Knych H, Tully TN, Paul-Murphy JR. PMID: 32237680.
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    30. Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia. J Vet Pharmacol Ther. 2020 Jul; 43(4):369-376. Guedes A, Knych H, Tucker L, Almeida DC, Baldo CF, Wendt-Hornickle E, Allweiler S. PMID: 32166760.
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    31. Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats. Front Vet Sci. 2020; 7:86. Yates LM, Aleman M, Knych HK, Knipe MF, Crowe CM, Chigerwe M. PMID: 32154280.
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    32. Pharmacokinetics and pharmacodynamics of clodronate disodium evaluated in plasma, synovial fluid and urine. Equine Vet J. 2020 Sep; 52(5):725-732. Krueger CR, Mitchell CF, Leise BS, Knych HK. PMID: 32003488.
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    33. Pharmacokinetics of maropitant citrate after oral administration of multiple doses in adult horses. J Vet Pharmacol Ther. 2020 May; 43(3):282-287. Berryhill EH, Knych H, Chigerwe M, Edman J, Magdesian KG. PMID: 32067245.
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    34. Pharmacokinetics and pharmacodynamics of hydromorphone after intravenous and intramuscular administration in horses. Vet Anaesth Analg. 2020 Mar; 47(2):210-218. Reed RA, Knych HK, Barletta M, Sakai DM, Ruch MM, Smyth CA, Ryan CA. PMID: 31959534.
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    35. Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2019 Oct; 80(10):963-968. Ozawa SM, Hawkins MG, Drazenovich TL, Kass PH, Knych HK. PMID: 31556710.
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    36. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2019 Nov; 42(6):617-623. Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS. PMID: 31490561.
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    37. Concentrations of medetomidine enantiomers and vatinoxan, an a2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. Vet Anaesth Analg. 2020 Jan; 47(1):47-52. Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM. PMID: 31761600.
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    38. Detection, pharmacokinetics, and selected pharmacodynamic effects of methamphetamine following a single transmucosal and intravenous administration to exercised Thoroughbred horses. Drug Test Anal. 2019 Sep; 11(9):1431-1443. Knych HK, Arthur RM, Kanarr KL, McKemie DS, Kass PH. PMID: 31218824.
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    39. Characterization of the in vitro CYP450 mediated metabolism of the polymorphic CYP2D6 probe drug codeine in horses. Biochem Pharmacol. 2019 10; 168:184-192. Knych HK, Baden RW, Gretler SR, McKemie DS. PMID: 31295464.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Pharmacokinetics of a Long-lasting, Highly Concentrated Buprenorphine Solution after Subcutaneous Administration in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2019 07 01; 58(4):501-509. Mackiewicz AL, Salyards GW, Knych HK, Hill AE, Christe KL. PMID: 31227029.
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    41. Evaluation of the sedative effects and pharmacokinetics of detomidine gel administered intravaginally to horses. Vet Anaesth Analg. 2019 Nov; 46(6):772-779. Seddighi R, Knych HK, Cox SK, Sun X, Moorhead KA, Doherty TJ. PMID: 31474339.
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    42. Pharmacokinetics of single doses of maropitant citrate in adult horses. J Vet Pharmacol Ther. 2019 Jul; 42(4):487-491. Berryhill EH, Knych H, Edman JM, Magdesian KG. PMID: 31190332.
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    43. Pharmacokinetics of chloramphenicol base in horses and comparison to compounded formulations. J Vet Pharmacol Ther. 2019 Nov; 42(6):609-616. Patel T, Magdesian KG, Estell KE, Edman JM, Knych HK. PMID: 31162675.
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    44. Pharmacokinetics and competitive pharmacodynamics of ADP-induced platelet activation after oral administration of clopidogrel to horses. Am J Vet Res. 2019 May; 80(5):505-512. Norris JW, Watson JL, Tablin F, Kozikowski TA, Knych HK. PMID: 31034271.
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    45. Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses. J Vet Pharmacol Ther. 2019 Jul; 42(4):401-410. Hamamoto-Hardman BD, Steffey EP, Weiner D, McKemie DS, Kass P, Knych HK. PMID: 30919469.
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    46. Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses. Drug Test Anal. 2019 Jun; 11(6):792-803. Knych HK, Arthur RM, McKemie DS, Seminoff K, Hamamoto-Hardman B, Kass PH. PMID: 30499176.
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    47. Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Dec; 79(12):1239-1245. Guzman DS, Houck EL, Knych HKD, Beaufrère H, Paul-Murphy JR. PMID: 30457903.
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    48. The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses. Vet Anaesth Analg. 2019 May; 46(3):395-404. Reed R, Barletta M, Mitchell K, Hanafi A, Bullington A, Knych H, Quandt J, Ryan C, Giguère S. PMID: 30930095.
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    49. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019; 103(1-2):10-16. Cenani A, Brosnan RJ, Knych HK. PMID: 30332672.
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    50. Plasma and synovial fluid concentrations and cartilage toxicity of bupivacaine following intra-articular administration of a liposomal formulation to horses. Equine Vet J. 2019 May; 51(3):408-414. Knych HK, Mama KR, Moore CE, Hill AE, McKEMIE DS. PMID: 30182426.
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    51. Pharmacokinetics of intravenous flumetasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse. Equine Vet J. 2019 Mar; 51(2):238-245. Knych HK, Arthur RM, McKemie DS, Baden R, Oldberg N, Kass PH. PMID: 30080272.
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    52. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 79(8):820-827. Houck EL, Guzman DS, Beaufrère H, Knych HK, Paul-Murphy JR. PMID: 30058846.
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    53. 5a-dihydroprogesterone concentrations and synthesis in non-pregnant mares. J Endocrinol. 2018 07; 238(1):25-32. Conley AJ, Scholtz EL, Legacki EL, Corbin CJ, Knych HK, Dujovne GD, Ball BA, Moeller BC, Stanley SD. PMID: 29853526.
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    54. L- and D-threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses. Drug Test Anal. 2018 Oct; 10(10):1508-1517. Knych HK, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D. PMID: 29786965.
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    55. Pharmacokinetics of fentanyl after intravenous administration in isoflurane-anesthetized red-tailed hawks (Buteo jamaicensis) and Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):606-613. Pascoe PJ, Pypendop BH, Pavez Phillips JC, DiMaio Knych HK, Sanchez-Migallon Guzman D, Hawkins MG. PMID: 30085853.
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    56. Effects of three fentanyl plasma concentrations on the minimum alveolar concentration of isoflurane in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):600-605. Hawkins MG, Pascoe PJ, DiMaio Knych HK, Drazenovich TL, Kass PH, Sanchez-Migallon Guzman D. PMID: 30085862.
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    57. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Test Anal. 2018 Mar 25. Knych HK, Seminoff K, McKemie DS. PMID: 29575649.
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    58. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 May; 32(3):1283-1289. Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. PMID: 29572958.
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    59. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar; 79(3):260-266. Sadar MJ, Knych HK, Drazenovich TL, Paul-Murphy JR. PMID: 29466036.
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    60. Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses. Am J Vet Res. 2018 Mar; 79(3):282-286. Kilcoyne I, Nieto JE, Knych HK, Dechant JE. PMID: 29466037.
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    61. Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2018 Aug; 41(4):522-535. Knych HK, Seminoff K, McKemie DS, Kass PH. PMID: 29457257.
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    62. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018 01 31; 16(5):698-702. Garg N, Hansson A, Knych HK, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D. PMID: 29319101.
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    63. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan; 79(1):13-20. Gleeson MD, Guzman DS, Knych HK, Kass PH, Drazenovich TL, Hawkins MG. PMID: 29287158.
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    64. Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 01; 1074-1075:91-98. Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M. PMID: 29334634.
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    65. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Vet J. 2018 Jul; 50(4):504-512. Knych HK, Harrison L, Chouicha N, Kass PH. PMID: 29044706.
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    66. Effectiveness of furosemide in attenuating exercise-induced pulmonary haemorrhage in horses when administered at 4- and 24-h prior to high-speed training. Equine Vet J. 2018 May; 50(3):350-355. Knych HK, Wilson WD, Vale A, Kass PH, Arthur RM, Jones JH. PMID: 28963734.
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    67. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2018 Apr; 41(2):230-238. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. PMID: 29067696.
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    68. Pharmacokinetics of furosemide administered 4 and 24 hours prior to high-speed exercise in horses. J Vet Pharmacol Ther. 2018 Apr; 41(2):224-229. Knych HK, Vale A, Wilson WD, Kass PH, Arthur RM, Jones JH. PMID: 29057472.
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    69. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. Am J Vet Res. 2017 Oct; 78(10):1182-1192. Knych HK, Mama KR, Steffey EP, Stanley SD, Kass PH. PMID: 28945130.
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    70. Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs. Vet Anaesth Analg. 2017 Nov; 44(6):1287-1295. Smith CK, Seddighi R, Cox SK, Sun X, Knych HK, Doherty TJ. PMID: 29074303.
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    71. Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1392-1399. Knych HK, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH. PMID: 28513092.
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    72. Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2017 Jul 01; 56(4):443-451. Salyards GW, Lemoy MJ, Knych HK, Hill AE, Christe KL. PMID: 28724494.
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    73. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun; 31(2):102-107. Guzman DS, Knych HK, Olsen GH, Paul-Murphy JR. PMID: 28644085.
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    74. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun; 78(6):677-687. Laniesse D, Smith DA, Knych HK, Mosley C, Guzman DS, Beaufrère H. PMID: 28541144.
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    75. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2017 Jun; 78(6):688-694. Laniesse D, Guzman DS, Knych HK, Smith DA, Mosley C, Paul-Murphy JR, Beaufrère H. PMID: 28541145.
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    76. Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream. Am J Vet Res. 2017 Apr; 78(4):405-411. Barnett SE, Sellon DC, Hines MT, Seino KK, Knych HK. PMID: 28346003.
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    77. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1385-1391. Knych HK, Stanley SD, Harrison LM, Mckemie DS. PMID: 28117560.
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    78. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul; 44(4):755-765. Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. PMID: 28734855.
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    79. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. PMID: 27426730.
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    80. Nonsteroidal Anti-inflammatory Drug Use in Horses. Vet Clin North Am Equine Pract. 2017 Apr; 33(1):1-15. Knych HK. PMID: 28190614.
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    81. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide. Vet Comp Oncol. 2017 Dec; 15(4):1558-1563. Burton JH, Knych HK, Stanley SD, Rebhun RB. PMID: 28120478.
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    82. Pharmacokinetics and selected pharmacodynamics of romifidine following low-dose intravenous administration in combination with exercise to quarter horses. J Vet Pharmacol Ther. 2017 Oct; 40(5):569-574. Knych HK, Stanley SD, McKemie DS, Steinmetz SJ. PMID: 28097665.
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    83. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun; 9(6):880-887. Corado CR, McKemie DS, Knych HK. PMID: 27580591.
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    84. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses. Drug Test Anal. 2017 May; 9(5):713-720. Knych HK, Stanley SD, McKemie DS, Arthur RM, Kass PH. PMID: 27492623.
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    85. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep; 77(9):1029-35. Corado CR, McKemie DS, Knych HK. PMID: 27580115.
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    86. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. BMC Genomics. 2016 08 09; 17:596. Knych HK, Harrison LM, Steinmetz SJ, Chouicha N, Kass PH. PMID: 27506674.
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    87. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug; 77(8):833-45. Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. PMID: 27463546.
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    88. Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses. J Vet Intern Med. 2016 Jul; 30(4):1322-6. Aleman M, Davis E, Knych H, Guedes A, Smith F, Madigan JE. PMID: 27362367.
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    89. Pharmacokinetic and pharmacodynamic properties of pergolide mesylate following long-term administration to horses with pituitary pars intermedia dysfunction. J Vet Pharmacol Ther. 2017 Apr; 40(2):158-164. McFarlane D, Banse H, Knych HK, Maxwell LK. PMID: 27301465.
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    90. Disposition of the anti-ulcer medications ranitidine, cimetidine, and omeprazole following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2017 Jan; 40(1):92-96. Knych HK, Stanley SD, Arthur RM, McKemie DS. PMID: 27292271.
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    91. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). J Zoo Wildl Med. 2016 Jun; 47(2):468-73. Waugh L, Knych H, Cole G, D'Agostino J. PMID: 27468018.
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    92. Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):522-4. Knych HK, Stanley SD, Arthur RM, McKemie DS. PMID: 27121892.
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    93. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016 Apr 15; 30(7):833-42. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. PMID: 26969924.
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    94. Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs. Am J Vet Res. 2016 Apr; 77(4):413-20. Messenger KM, Hopfensperger M, Knych HK, Papich MG. PMID: 27027842.
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    95. Pharmacokinetics of methocarbamol and phenylbutazone in exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):469-77. Knych HK, Stanley SD, Seminoff KN, McKemie DS, Kass PH. PMID: 26924025.
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    96. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb; 77(2):119-26. Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych HK, Scharf AM, Quandt JE. PMID: 27027704.
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    97. Serum, milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation. J Vet Pharmacol Ther. 2016 Aug; 39(4):363-72. Puschner B, Bautista AC, McKemie DS, Gallego SM, Woods LW, Moore CE, Knych HK. PMID: 26763112.
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    98. Pharmacokinetics of guaifenesin following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Aug; 39(4):416-9. Knych HK, Stanley SD, Benson D, Arthur RM. PMID: 26763117.
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    99. Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra-articular administration of triamcinolone acetonide in exercised horses. Equine Vet J. 2017 Jan; 49(1):107-115. Knych HK, Vidal MA, Chouicha N, Mitchell M, Kass PH. PMID: 26518341.
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    100. Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals. Equine Vet J. 2016 Jan; 48(1):65-71. Knych HK, Steffey EP, White AM, McKemie DS. PMID: 27030842.
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    101. Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. Vet J. 2016 Jan; 207:196-8. Knych HK, Arthur RM, Steinmetz S, McKemie DS. PMID: 27152386.
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    102. Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. J Vet Intern Med. 2016 Jan-Feb; 30(1):242-6. Burton JH, Stanley SD, Knych HK, Rodriguez CO, Skorupski KA, Rebhun RB. PMID: 26682700.
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    103. Evidence for polymorphism in the cytochrome P450 2D50 gene in horses. J Vet Pharmacol Ther. 2016 Jun; 39(3):245-54. Corado CR, McKemie DS, Young A, Knych HK. PMID: 26441153.
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    104. Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. 2016 Jan; 8(1):141-7. Knych HK, Harrison LM, White A, McKemie DS. PMID: 26333097.
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    105. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration. J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):557-63. Salyards GW, Knych HK, Hill AE, Kelly KR, Christe KL. PMID: 26424255.
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    106. Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol. Equine Vet J. 2016 Jul; 48(4):528-31. Guedes A, Knych H, Hood D. PMID: 25832551.
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    107. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2016 Jan; 43(1):35-43. Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. PMID: 25943714.
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    108. Pharmacokinetics of a single subcutaneous dose of sustained release buprenorphine in northern elephant seals (Mirounga angustirostris). J Zoo Wildl Med. 2015 Mar; 46(1):52-61. Molter CM, Barbosa L, Johnson S, Knych HK, Chinnadurai SK, Wack RF. PMID: 25831576.
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    109. Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses. J Vet Pharmacol Ther. 2015 Aug; 38(4):313-20. Knych HK, Arthur RM, McKemie DS, Chapman N. PMID: 25582761.
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    110. Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes. Drug Test Anal. 2015 Aug; 7(8):673-83. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. PMID: 25560998.
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    111. Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals. Equine Vet J. 2015 01; 47(1):72-7. Knych HK, Steffey EP, Mitchell MM, Casbeer HC. PMID: 25263971.
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    112. Chapter 13 Analgesic Pharmacology. . 2015 Jan 1; (Vet Anaesth Analg362009):55-57. Heather K. Knych. .
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    113. Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses. Drug Test Anal. 2015 Jul; 7(7):619-25. Knych HK, Arthur RM, Mitchell MM, Holser I, Poppenga R, Smith LL, Helm MN, Sams RA, Gaskill CL. PMID: 25327415.
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    114. Pharmacokinetics of metronidazole in foals: influence of age within the neonatal period. J Vet Pharmacol Ther. 2015 Jun; 38(3):227-34. Swain EA, Magdesian KG, Kass PH, Edman JE, Knych HK. PMID: 25271172.
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    115. Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals. Equine Vet J. 2015 Sep; 47(5):592-8. Knych HK, Steffey EP, Casbeer HC, Mitchell MM. PMID: 24978306.
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    116. Disposition and metabolic profile of the weak androgen Dehydroepiandrosterone (DHEA) following administration as part of a nutritional supplement to exercised horses. Drug Test Anal. 2015 Jan; 7(1):39-47. Knych HK, Arthur RM, Stanley SD, McKemie DS. PMID: 25242721.
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    117. Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses. J Vet Pharmacol Ther. 2015 Apr; 38(2):113-22. Knych HK, Steinmetz SJ, McKemie DS. PMID: 25131315.
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    118. Pharmacokinetics of buprenorphine hydrochloride following intramuscular and intravenous administration to American kestrels (Falco sparverius). Am J Vet Res. 2014 Aug; 75(8):711-5. Gustavsen KA, Guzman DS, Knych HK, Petritz OA, Olsen GH, Paul-Murphy JR. PMID: 25061701.
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    119. Preliminary pharmacokinetics of morphine and its major metabolites following intravenous administration of four doses to horses. J Vet Pharmacol Ther. 2014 Aug; 37(4):374-81. Knych HK, Steffey EP, McKemie DS. PMID: 24479785.
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    120. Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Vet J. 2014 Nov; 46(6):734-8. Knych HK, Stanley SD, Arthur RM, Mitchell MM. PMID: 24393414.
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    121. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2014 Jun; 37(3):269-78. Guedes AG, Knych HK, Soares JH, Brosnan RJ. PMID: 24180699.
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    122. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Vet Anaesth Analg. 2014 Jan; 41(1):36-47. Knych HK, Stanley SD. PMID: 24134603.
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    123. Detection, pharmacokinetics and cardiac effects following administration of clenbuterol to exercised horses. Equine Vet J. 2014 May; 46(3):380-5. Knych HK, Mitchell MM, Steinmetz SJ, McKemie DS. PMID: 23773115.
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    124. Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. J Vet Pharmacol Ther. 2014 Apr; 37(2):125-32. Knych HK, Harrison LM, Casbeer HC, McKemie DS. PMID: 23876165.
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    125. Pharmacokinetics of triamcinolone acetonide following intramuscular and intra-articular administration to exercised Thoroughbred horses. Equine Vet J. 2013 Nov; 45(6):715-20. Knych HK, Vidal MA, Casbeer HC, McKemie DS. PMID: 23574452.
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    126. Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Am J Vet Res. 2013 Apr; 74(4):550-6. Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR. PMID: 23531062.
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    127. Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. Vet J. 2013 Jun; 196(3):504-9. Casbeer HC, Knych HK. PMID: 23321455.
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    128. Pharmacokinetics and selected pharmacodynamic effects of tramadol following intravenous administration to the horse. Equine Vet J. 2013 Jul; 45(4):490-6. Knych HK, Corado CR, McKemie DS, Steffey EP. PMID: 23145962.
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    129. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Vet Anaesth Analg. 2012 Nov; 39(6):574-83. DiMaio Knych HK, Covarrubias V, Steffey EP. PMID: 23035904.
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    130. Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. J Vet Pharmacol Ther. 2013 Aug; 36(4):389-98. Knych HK, Corado CR, McKemie DS, Scholtz E, Sams R. PMID: 23061925.
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    131. The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse. Vet Anaesth Analg. 2012 May; 39(3):221-9. Knych HK, Steffey EP, Stanley SD. PMID: 22405129.
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    132. Pharmacokinetics and pharmacodynamics of butorphanol following intravenous administration to the horse. J Vet Pharmacol Ther. 2013 Feb; 36(1):21-30. Knych HK, Casbeer HC, McKemie DS, Arthur RM. PMID: 22339417.
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    133. Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses. Am J Vet Res. 2011 Oct; 72(10):1378-85. Dimaio Knych HK, Stanley SD. PMID: 21962281.
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    134. Distribution of flunixin meglumine and firocoxib into aqueous humor of horses. J Vet Intern Med. 2011 Sep-Oct; 25(5):1127-33. Hilton HG, Magdesian KG, Groth AD, Knych H, Stanley SD, Hollingsworth SR. PMID: 21781166.
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    135. Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis). Vet Anaesth Analg. 2011 Jul; 38(4):344-51. Pavez JC, Hawkins MG, Pascoe PJ, Knych HK, Kass PH. PMID: 21672126.
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    136. Pharmacokinetics and metabolism of dantrolene in horses. J Vet Pharmacol Ther. 2011 Jun; 34(3):238-46. DiMaio Knych HK, Arthur RM, Taylor A, Moeller BC, Stanley SD. PMID: 21492188.
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    137. Pharmacokinetics of yohimbine following intravenous administration to horses. J Vet Pharmacol Ther. 2011 Feb; 34(1):58-63. Dimaio Knych HK, Steffey EP, Deuel JL, Shepard RA, Stanley SD. PMID: 21219345.
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    138. Pharmacokinetics and pharmacodynamics of three intravenous doses of yohimbine in the horse. J Vet Pharmacol Ther. 2011 Aug; 34(4):359-66. Dimaio Knych HK, Steffey EP, Stanley SD. PMID: 20950351.
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    139. Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses. Drug Metab Dispos. 2010 Oct; 38(10):1820-7. Knych HK, McKemie DS, Stanley SD. PMID: 20587621.
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    140. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. Am J Vet Res. 2009 Oct; 70(10):1193-200. Knych HK, Steffey EP, Mama KR, Stanley SD. PMID: 19795933.
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    141. Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009 May 01; 485(1):49-55. DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD. PMID: 19245785.
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    142. Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol. 2008 Oct 01; 76(7):904-11. DiMaio Knych HK, Stanley SD. PMID: 18692486.
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