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Heather Knych

TitleASSOC PROF OF CLIN-FY
InstitutionUniversity of California Davis
DepartmentCA ANIMAL HLTH&FOOD SAFETY LAB
AddressK.L. Maddy Equine Analytical Chemistry Laboratory
CA 95616
Phone530-752-8700
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Houck EL, Guzman DS, Beaufrère H, Knych H, Paul-Murphy JR. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 79(8):820-827. PMID: 30058846.
      View in: PubMed
    2. Knych H, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D. L- and D-threo Ethylphenidate Concentrations, Pharmacokinetics and Pharmacodynamics in Horses. Drug Test Anal. 2018 May 22. PMID: 29786965.
      View in: PubMed
    3. Knych H, Seminoff K, McKemie DS. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Test Anal. 2018 Mar 25. PMID: 29575649.
      View in: PubMed
    4. Balcomb CC, Heller MC, Chigerwe M, Knych H, Meyer AM. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 Mar 23. PMID: 29572958.
      View in: PubMed
    5. Sadar MJ, Knych H, Drazenovich TL, Paul-Murphy JR. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar; 79(3):260-266. PMID: 29466036.
      View in: PubMed
    6. Kilcoyne I, Nieto JE, Knych H, Dechant JE. Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses. Am J Vet Res. 2018 Mar; 79(3):282-286. PMID: 29466037.
      View in: PubMed
    7. Garg N, Hansson A, Knych H, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018 Jan 31; 16(5):698-702. PMID: 29319101.
      View in: PubMed
    8. Gleeson MD, Guzman DS, Knych H, Kass PH, Drazenovich TL, Hawkins MG. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan; 79(1):13-20. PMID: 29287158.
      View in: PubMed
    9. Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M. Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 01; 1074-1075:91-98. PMID: 29334634.
      View in: PubMed
    10. Knych H, Mama KR, Steffey EP, Stanley SD, Kass PH. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. Am J Vet Res. 2017 Oct; 78(10):1182-1192. PMID: 28945130.
      View in: PubMed
    11. Smith CK, Seddighi R, Cox SK, Sun X, Knych H, Doherty TJ. Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs. Vet Anaesth Analg. 2017 Nov; 44(6):1287-1295. PMID: 29074303.
      View in: PubMed
    12. Knych H, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH. Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1392-1399. PMID: 28513092.
      View in: PubMed
    13. Salyards GW, Lemoy MJ, Knych H, Hill AE, Christe KL. Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2017 Jul 01; 56(4):443-451. PMID: 28724494.
      View in: PubMed
    14. Laniesse D, Smith DA, Knych H, Mosley C, Guzman DS, Beaufrère H. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun; 78(6):677-687. PMID: 28541144.
      View in: PubMed
    15. Laniesse D, Guzman DS, Knych H, Smith DA, Mosley C, Paul-Murphy JR, Beaufrère H. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2017 Jun; 78(6):688-694. PMID: 28541145.
      View in: PubMed
    16. Guzman DS, Knych H, Olsen GH, Paul-Murphy JR. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun; 31(2):102-107. PMID: 28644085.
      View in: PubMed
    17. Barnett SE, Sellon DC, Hines MT, Seino KK, Knych H. Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream. Am J Vet Res. 2017 Apr; 78(4):405-411. PMID: 28346003.
      View in: PubMed
    18. Knych H, Stanley SD, Harrison LM, Mckemie DS. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1385-1391. PMID: 28117560.
      View in: PubMed
    19. Hector RC, Rezende ML, Mama KR, Steffey EP, Knych H, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul; 44(4):755-765. PMID: 28734855.
      View in: PubMed
    20. Cenani A, Brosnan RJ, Madigan S, Knych H, Madigan JE. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. PMID: 27426730.
      View in: PubMed
    21. Knych H. Nonsteroidal Anti-inflammatory Drug Use in Horses. Vet Clin North Am Equine Pract. 2017 Apr; 33(1):1-15. PMID: 28190614.
      View in: PubMed
    22. Corado CR, McKemie DS, Knych H. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun; 9(6):880-887. PMID: 27580591.
      View in: PubMed
    23. Knych H, Stanley SD, McKemie DS, Arthur RM, Kass PH. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses. Drug Test Anal. 2017 May; 9(5):713-720. PMID: 27492623.
      View in: PubMed
    24. Corado CR, McKemie DS, Knych H. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep; 77(9):1029-35. PMID: 27580115.
      View in: PubMed
    25. Knych H, Harrison LM, Steinmetz SJ, Chouicha N, Kass PH. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. BMC Genomics. 2016 08 09; 17:596. PMID: 27506674; PMCID: PMC4979108.
    26. Sebbag L, Thomasy SM, Woodward AP, Knych H, Maggs DJ. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug; 77(8):833-45. PMID: 27463546.
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    27. Waugh L, Knych H, Cole G, D'Agostino J. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). J Zoo Wildl Med. 2016 Jun; 47(2):468-73. PMID: 27468018.
      View in: PubMed
    28. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016 Apr 15; 30(7):833-42. PMID: 26969924.
      View in: PubMed
    29. Messenger KM, Hopfensperger M, Knych H, Papich MG. Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs. Am J Vet Res. 2016 Apr; 77(4):413-20. PMID: 27027842.
      View in: PubMed
    30. Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych H, Scharf AM, Quandt JE. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb; 77(2):119-26. PMID: 27027704.
      View in: PubMed
    31. Knych H, Arthur RM, Steinmetz S, McKemie DS. Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. Vet J. 2016 Jan; 207:196-8. PMID: 27152386.
      View in: PubMed
    32. Knych H, Harrison LM, White A, McKemie DS. Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. 2016 Jan; 8(1):141-7. PMID: 26333097.
      View in: PubMed
    33. Salyards GW, Knych H, Hill AE, Kelly KR, Christe KL. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration. J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):557-63. PMID: 26424255; PMCID: PMC4587625.
    34. Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2016 Jan; 43(1):35-43. PMID: 25943714.
      View in: PubMed
    35. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes. Drug Test Anal. 2015 Aug; 7(8):673-83. PMID: 25560998.
      View in: PubMed
    36. Gustavsen KA, Guzman DS, Knych H, Petritz OA, Olsen GH, Paul-Murphy JR. Pharmacokinetics of buprenorphine hydrochloride following intramuscular and intravenous administration to American kestrels (Falco sparverius). Am J Vet Res. 2014 Aug; 75(8):711-5. PMID: 25061701.
      View in: PubMed
    37. Knych H, Stanley SD. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Vet Anaesth Analg. 2014 Jan; 41(1):36-47. PMID: 24134603.
      View in: PubMed
    38. Nieto JE, Maher O, Stanley SD, Knych H, Snyder JR. Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Am J Vet Res. 2013 Apr; 74(4):550-6. PMID: 23531062.
      View in: PubMed
    39. Knych H, Corado CR, McKemie DS, Steffey EP. Pharmacokinetics and selected pharmacodynamic effects of tramadol following intravenous administration to the horse. Equine Vet J. 2013 Jul; 45(4):490-6. PMID: 23145962.
      View in: PubMed
    40. DiMaio Knych HK, Covarrubias V, Steffey EP. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Vet Anaesth Analg. 2012 Nov; 39(6):574-83. PMID: 23035904.
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    41. Knych H, Corado CR, McKemie DS, Scholtz E, Sams R. Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. J Vet Pharmacol Ther. 2013 Aug; 36(4):389-98. PMID: 23061925.
      View in: PubMed
    42. Knych H, Steffey EP, Stanley SD. The effects of yohimbine on the pharmacokinetic parameters of detomidine in the horse. Vet Anaesth Analg. 2012 May; 39(3):221-9. PMID: 22405129.
      View in: PubMed
    43. Knych H, Casbeer HC, McKemie DS, Arthur RM. Pharmacokinetics and pharmacodynamics of butorphanol following intravenous administration to the horse. J Vet Pharmacol Ther. 2013 Feb; 36(1):21-30. PMID: 22339417.
      View in: PubMed
    44. Dimaio Knych HK, Stanley SD. Pharmacokinetics and pharmacodynamics of detomidine following sublingual administration to horses. Am J Vet Res. 2011 Oct; 72(10):1378-85. PMID: 21962281.
      View in: PubMed
    45. Pavez JC, Hawkins MG, Pascoe PJ, Knych H, Kass PH. Effect of fentanyl target-controlled infusions on isoflurane minimum anaesthetic concentration and cardiovascular function in red-tailed hawks (Buteo jamaicensis). Vet Anaesth Analg. 2011 Jul; 38(4):344-51. PMID: 21672126.
      View in: PubMed
    46. DiMaio Knych HK, Arthur RM, Taylor A, Moeller BC, Stanley SD. Pharmacokinetics and metabolism of dantrolene in horses. J Vet Pharmacol Ther. 2011 Jun; 34(3):238-46. PMID: 21492188.
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    47. Dimaio Knych HK, Steffey EP, Deuel JL, Shepard RA, Stanley SD. Pharmacokinetics of yohimbine following intravenous administration to horses. J Vet Pharmacol Ther. 2011 Feb; 34(1):58-63. PMID: 21219345.
      View in: PubMed
    48. Dimaio Knych HK, Steffey EP, Stanley SD. Pharmacokinetics and pharmacodynamics of three intravenous doses of yohimbine in the horse. J Vet Pharmacol Ther. 2011 Aug; 34(4):359-66. PMID: 20950351.
      View in: PubMed
    49. Knych H, McKemie DS, Stanley SD. Molecular cloning, expression, and initial characterization of members of the CYP3A family in horses. Drug Metab Dispos. 2010 Oct; 38(10):1820-7. PMID: 20587621.
      View in: PubMed
    50. Knych H, Steffey EP, Mama KR, Stanley SD. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. Am J Vet Res. 2009 Oct; 70(10):1193-200. PMID: 19795933.
      View in: PubMed
    51. DiMaio Knych HK, DeStefano Shields C, Buckpitt AR, Stanley SD. Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization. Arch Biochem Biophys. 2009 May 01; 485(1):49-55. PMID: 19245785.
      View in: PubMed
    52. DiMaio Knych HK, Stanley SD. Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. Biochem Pharmacol. 2008 Oct 01; 76(7):904-11. PMID: 18692486.
      View in: PubMed