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Heather K Knych, PhD; DVM

Title(s)Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
Phone530-752-8700
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Reed RA, Knych HK, Barletta M, Sakai DM, Ruch MM, Smyth CA, Ryan CA. Pharmacokinetics and pharmacodynamics of hydromorphone after intravenous and intramuscular administration in horses. Vet Anaesth Analg. 2019 Nov 05. PMID: 31959534.
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    2. Ozawa SM, Hawkins MG, Drazenovich TL, Kass PH, Knych HK. Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2019 Oct; 80(10):963-968. PMID: 31556710.
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    3. Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2019 Nov; 42(6):617-623. PMID: 31490561.
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    4. Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM. Concentrations of medetomidine enantiomers and vatinoxan, an a2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. Vet Anaesth Analg. 2020 Jan; 47(1):47-52. PMID: 31761600.
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    5. Knych HK, Arthur RM, Kanarr KL, McKemie DS, Kass PH. Detection, pharmacokinetics, and selected pharmacodynamic effects of methamphetamine following a single transmucosal and intravenous administration to exercised Thoroughbred horses. Drug Test Anal. 2019 Sep; 11(9):1431-1443. PMID: 31218824.
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    6. Knych HK, Baden RW, Gretler SR, McKemie DS. Characterization of the in vitro CYP450 mediated metabolism of the polymorphic CYP2D6 probe drug codeine in horses. Biochem Pharmacol. 2019 Oct; 168:184-192. PMID: 31295464.
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    7. Mackiewicz AL, Salyards GW, Knych HK, Hill AE, Christe KL. Pharmacokinetics of a Long-lasting, Highly Concentrated Buprenorphine Solution after Subcutaneous Administration in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2019 Jul 01; 58(4):501-509. PMID: 31227029.
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    8. Seddighi R, Knych HK, Cox SK, Sun X, Moorhead KA, Doherty TJ. Evaluation of the sedative effects and pharmacokinetics of detomidine gel administered intravaginally to horses. Vet Anaesth Analg. 2019 Nov; 46(6):772-779. PMID: 31474339.
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    9. Berryhill EH, Knych H, Edman JM, Magdesian KG. Pharmacokinetics of single doses of maropitant citrate in adult horses. J Vet Pharmacol Ther. 2019 Jul; 42(4):487-491. PMID: 31190332.
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    10. Patel T, Magdesian KG, Estell KE, Edman JM, Knych HK. Pharmacokinetics of chloramphenicol base in horses and comparison to compounded formulations. J Vet Pharmacol Ther. 2019 Nov; 42(6):609-616. PMID: 31162675.
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    11. Norris JW, Watson JL, Tablin F, Kozikowski TA, Knych HK. Pharmacokinetics and competitive pharmacodynamics of ADP-induced platelet activation after oral administration of clopidogrel to horses. Am J Vet Res. 2019 May; 80(5):505-512. PMID: 31034271.
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    12. Hamamoto-Hardman BD, Steffey EP, Weiner D, McKemie DS, Kass P, Knych HK. Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses. J Vet Pharmacol Ther. 2019 Jul; 42(4):401-410. PMID: 30919469.
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    13. Knych HK, Arthur RM, McKemie DS, Seminoff K, Hamamoto-Hardman B, Kass PH. Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses. Drug Test Anal. 2019 Jun; 11(6):792-803. PMID: 30499176.
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    14. Guzman DS, Houck EL, Knych HKD, Beaufrère H, Paul-Murphy JR. Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Dec; 79(12):1239-1245. PMID: 30457903.
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    15. Reed R, Barletta M, Mitchell K, Hanafi A, Bullington A, Knych H, Quandt J, Ryan C, Giguère S. The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses. Vet Anaesth Analg. 2019 May; 46(3):395-404. PMID: 30930095.
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    16. Cenani A, Brosnan RJ, Knych HK. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019; 103(1-2):10-16. PMID: 30332672.
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    17. Knych HK, Mama KR, Moore CE, Hill AE, McKEMIE DS. Plasma and synovial fluid concentrations and cartilage toxicity of bupivacaine following intra-articular administration of a liposomal formulation to horses. Equine Vet J. 2019 May; 51(3):408-414. PMID: 30182426.
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    18. Knych HK, Arthur RM, McKemie DS, Baden R, Oldberg N, Kass PH. Pharmacokinetics of intravenous flumetasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse. Equine Vet J. 2019 Mar; 51(2):238-245. PMID: 30080272.
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    19. Houck EL, Guzman DS, Beaufrère H, Knych HK, Paul-Murphy JR. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 79(8):820-827. PMID: 30058846.
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    20. Conley AJ, Scholtz EL, Legacki EL, Corbin CJ, Knych HK, Dujovne GD, Ball BA, Moeller BC, Stanley SD. 5a-dihydroprogesterone concentrations and synthesis in non-pregnant mares. J Endocrinol. 2018 07; 238(1):25-32. PMID: 29853526.
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    21. Knych HK, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D. L- and D-threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses. Drug Test Anal. 2018 Oct; 10(10):1508-1517. PMID: 29786965.
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    22. Pascoe PJ, Pypendop BH, Pavez Phillips JC, DiMaio Knych HK, Sanchez-Migallon Guzman D, Hawkins MG. Pharmacokinetics of fentanyl after intravenous administration in isoflurane-anesthetized red-tailed hawks (Buteo jamaicensis) and Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):606-613. PMID: 30085853.
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    23. Hawkins MG, Pascoe PJ, DiMaio Knych HK, Drazenovich TL, Kass PH, Sanchez-Migallon Guzman D. Effects of three fentanyl plasma concentrations on the minimum alveolar concentration of isoflurane in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2018 Jun; 79(6):600-605. PMID: 30085862.
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    24. Knych HK, Seminoff K, McKemie DS. Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses. Drug Test Anal. 2018 Mar 25. PMID: 29575649.
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    25. Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018 May; 32(3):1283-1289. PMID: 29572958.
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    26. Sadar MJ, Knych HK, Drazenovich TL, Paul-Murphy JR. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar; 79(3):260-266. PMID: 29466036.
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    27. Kilcoyne I, Nieto JE, Knych HK, Dechant JE. Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses. Am J Vet Res. 2018 Mar; 79(3):282-286. PMID: 29466037.
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    28. Knych HK, Seminoff K, McKemie DS, Kass PH. Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2018 Aug; 41(4):522-535. PMID: 29457257.
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    29. Garg N, Hansson A, Knych HK, Stanley SD, Thevis M, Bondesson U, Hedeland M, Globisch D. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018 01 31; 16(5):698-702. PMID: 29319101.
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    30. Gleeson MD, Guzman DS, Knych HK, Kass PH, Drazenovich TL, Hawkins MG. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan; 79(1):13-20. PMID: 29287158.
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    31. Hansson A, Knych H, Stanley S, Berndtson E, Jackson L, Bondesson U, Thevis M, Hedeland M. Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 01; 1074-1075:91-98. PMID: 29334634.
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    32. Knych HK, Harrison L, Chouicha N, Kass PH. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Vet J. 2018 Jul; 50(4):504-512. PMID: 29044706.
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    33. Knych HK, Wilson WD, Vale A, Kass PH, Arthur RM, Jones JH. Effectiveness of furosemide in attenuating exercise-induced pulmonary haemorrhage in horses when administered at 4- and 24-h prior to high-speed training. Equine Vet J. 2018 May; 50(3):350-355. PMID: 28963734.
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    34. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther. 2018 Apr; 41(2):230-238. PMID: 29067696.
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    35. Knych HK, Vale A, Wilson WD, Kass PH, Arthur RM, Jones JH. Pharmacokinetics of furosemide administered 4 and 24 hours prior to high-speed exercise in horses. J Vet Pharmacol Ther. 2018 Apr; 41(2):224-229. PMID: 29057472.
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    36. Knych HK, Mama KR, Steffey EP, Stanley SD, Kass PH. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training. Am J Vet Res. 2017 Oct; 78(10):1182-1192. PMID: 28945130.
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    37. Smith CK, Seddighi R, Cox SK, Sun X, Knych HK, Doherty TJ. Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs. Vet Anaesth Analg. 2017 Nov; 44(6):1287-1295. PMID: 29074303.
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    38. Knych HK, Stanley SD, McKemie DS, Arthur RM, Bondesson U, Hedeland M, Thevis M, Kass PH. Pharmacokinetics and pharmacodynamics of meldonium in exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1392-1399. PMID: 28513092.
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    39. Salyards GW, Lemoy MJ, Knych HK, Hill AE, Christe KL. Pharmacokinetics of a Novel, Transdermal Fentanyl Solution in Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2017 Jul 01; 56(4):443-451. PMID: 28724494.
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    40. Guzman DS, Knych HK, Olsen GH, Paul-Murphy JR. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun; 31(2):102-107. PMID: 28644085.
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    41. Laniesse D, Smith DA, Knych HK, Mosley C, Guzman DS, Beaufrère H. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun; 78(6):677-687. PMID: 28541144.
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    42. Laniesse D, Guzman DS, Knych HK, Smith DA, Mosley C, Paul-Murphy JR, Beaufrère H. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2017 Jun; 78(6):688-694. PMID: 28541145.
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    43. Barnett SE, Sellon DC, Hines MT, Seino KK, Knych HK. Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream. Am J Vet Res. 2017 Apr; 78(4):405-411. PMID: 28346003.
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    44. Knych HK, Stanley SD, Harrison LM, Mckemie DS. Pharmacokinetics of betamethasone in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. Drug Test Anal. 2017 Sep; 9(9):1385-1391. PMID: 28117560.
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    45. Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul; 44(4):755-765. PMID: 28734855.
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    46. Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan; 44(1):86-97. PMID: 27426730.
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    47. Knych HK. Nonsteroidal Anti-inflammatory Drug Use in Horses. Vet Clin North Am Equine Pract. 2017 Apr; 33(1):1-15. PMID: 28190614.
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    48. Burton JH, Knych HK, Stanley SD, Rebhun RB. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide. Vet Comp Oncol. 2017 Dec; 15(4):1558-1563. PMID: 28120478.
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    49. Knych HK, Stanley SD, McKemie DS, Steinmetz SJ. Pharmacokinetics and selected pharmacodynamics of romifidine following low-dose intravenous administration in combination with exercise to quarter horses. J Vet Pharmacol Ther. 2017 Oct; 40(5):569-574. PMID: 28097665.
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    50. Corado CR, McKemie DS, Knych HK. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun; 9(6):880-887. PMID: 27580591.
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    51. Knych HK, Stanley SD, McKemie DS, Arthur RM, Kass PH. Pharmacokinetic and pharmacodynamics of xylazine administered to exercised thoroughbred horses. Drug Test Anal. 2017 May; 9(5):713-720. PMID: 27492623.
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    52. Corado CR, McKemie DS, Knych HK. Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds. Am J Vet Res. 2016 Sep; 77(9):1029-35. PMID: 27580115.
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    53. Knych HK, Harrison LM, Steinmetz SJ, Chouicha N, Kass PH. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. BMC Genomics. 2016 08 09; 17:596. PMID: 27506674.
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    54. Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug; 77(8):833-45. PMID: 27463546.
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    55. Aleman M, Davis E, Knych H, Guedes A, Smith F, Madigan JE. Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses. J Vet Intern Med. 2016 Jul; 30(4):1322-6. PMID: 27362367.
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    56. McFarlane D, Banse H, Knych HK, Maxwell LK. Pharmacokinetic and pharmacodynamic properties of pergolide mesylate following long-term administration to horses with pituitary pars intermedia dysfunction. J Vet Pharmacol Ther. 2017 Apr; 40(2):158-164. PMID: 27301465.
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    57. Knych HK, Stanley SD, Arthur RM, McKemie DS. Disposition of the anti-ulcer medications ranitidine, cimetidine, and omeprazole following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2017 Jan; 40(1):92-96. PMID: 27292271.
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    58. Waugh L, Knych H, Cole G, D'Agostino J. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS). J Zoo Wildl Med. 2016 Jun; 47(2):468-73. PMID: 27468018.
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    59. Knych HK, Stanley SD, Arthur RM, McKemie DS. Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):522-4. PMID: 27121892.
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    60. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016 Apr 15; 30(7):833-42. PMID: 26969924.
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    61. Messenger KM, Hopfensperger M, Knych HK, Papich MG. Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs. Am J Vet Res. 2016 Apr; 77(4):413-20. PMID: 27027842.
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    62. Knych HK, Stanley SD, Seminoff KN, McKemie DS, Kass PH. Pharmacokinetics of methocarbamol and phenylbutazone in exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Oct; 39(5):469-77. PMID: 26924025.
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    63. Barletta M, Kleine SA, Hofmeister EH, Thoresen M, Peroni JF, Knych HK, Scharf AM, Quandt JE. Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl. Am J Vet Res. 2016 Feb; 77(2):119-26. PMID: 27027704.
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    64. Puschner B, Bautista AC, McKemie DS, Gallego SM, Woods LW, Moore CE, Knych HK. Serum, milk, and tissue monensin concentrations in cattle with adequate and potentially toxic dietary levels of monensin: pharmacokinetics and diagnostic interpretation. J Vet Pharmacol Ther. 2016 Aug; 39(4):363-72. PMID: 26763112.
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    65. Knych HK, Stanley SD, Benson D, Arthur RM. Pharmacokinetics of guaifenesin following administration of multiple doses to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2016 Aug; 39(4):416-9. PMID: 26763117.
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    66. Knych HK, Vidal MA, Chouicha N, Mitchell M, Kass PH. Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra-articular administration of triamcinolone acetonide in exercised horses. Equine Vet J. 2017 Jan; 49(1):107-115. PMID: 26518341.
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    67. Knych HK, Steffey EP, White AM, McKemie DS. Effects of age on the pharmacokinetics of tramadol and its active metabolite, O-desmethyltramadol following intravenous administration to foals. Equine Vet J. 2016 Jan; 48(1):65-71. PMID: 27030842.
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    68. Knych HK, Arthur RM, Steinmetz S, McKemie DS. Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses. Vet J. 2016 Jan; 207:196-8. PMID: 27152386.
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    69. Burton JH, Stanley SD, Knych HK, Rodriguez CO, Skorupski KA, Rebhun RB. Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. J Vet Intern Med. 2016 Jan-Feb; 30(1):242-6. PMID: 26682700.
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    70. Corado CR, McKemie DS, Young A, Knych HK. Evidence for polymorphism in the cytochrome P450 2D50 gene in horses. J Vet Pharmacol Ther. 2016 Jun; 39(3):245-54. PMID: 26441153.
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    71. Knych HK, Harrison LM, White A, McKemie DS. Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. 2016 Jan; 8(1):141-7. PMID: 26333097.
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    72. Salyards GW, Knych HK, Hill AE, Kelly KR, Christe KL. Pharmacokinetics of Ceftiofur Crystalline Free Acid in Male Rhesus Macaques (Macaca mulatta) after Subcutaneous Administration. J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):557-63. PMID: 26424255.
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    73. Guedes A, Knych H, Hood D. Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol. Equine Vet J. 2016 Jul; 48(4):528-31. PMID: 25832551.
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    74. Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Vet Anaesth Analg. 2016 Jan; 43(1):35-43. PMID: 25943714.
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    75. Molter CM, Barbosa L, Johnson S, Knych HK, Chinnadurai SK, Wack RF. Pharmacokinetics of a single subcutaneous dose of sustained release buprenorphine in northern elephant seals (Mirounga angustirostris). J Zoo Wildl Med. 2015 Mar; 46(1):52-61. PMID: 25831576.
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    76. Knych HK, Arthur RM, McKemie DS, Chapman N. Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses. J Vet Pharmacol Ther. 2015 Aug; 38(4):313-20. PMID: 25582761.
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    77. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes. Drug Test Anal. 2015 Aug; 7(8):673-83. PMID: 25560998.
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    78. Knych HK, Steffey EP, Mitchell MM, Casbeer HC. Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals. Equine Vet J. 2015 01; 47(1):72-7. PMID: 25263971.
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    79. Knych HK, Arthur RM, Mitchell MM, Holser I, Poppenga R, Smith LL, Helm MN, Sams RA, Gaskill CL. Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses. Drug Test Anal. 2015 Jul; 7(7):619-25. PMID: 25327415.
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    80. Swain EA, Magdesian KG, Kass PH, Edman JE, Knych HK. Pharmacokinetics of metronidazole in foals: influence of age within the neonatal period. J Vet Pharmacol Ther. 2015 Jun; 38(3):227-34. PMID: 25271172.
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    81. Knych HK, Steffey EP, Casbeer HC, Mitchell MM. Disposition, behavioural and physiological effects of escalating doses of intravenously administered fentanyl to young foals. Equine Vet J. 2015 Sep; 47(5):592-8. PMID: 24978306.
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    82. Knych HK, Arthur RM, Stanley SD, McKemie DS. Disposition and metabolic profile of the weak androgen Dehydroepiandrosterone (DHEA) following administration as part of a nutritional supplement to exercised horses. Drug Test Anal. 2015 Jan; 7(1):39-47. PMID: 25242721.
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    83. Knych HK, Steinmetz SJ, McKemie DS. Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses. J Vet Pharmacol Ther. 2015 Apr; 38(2):113-22. PMID: 25131315.
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    84. Gustavsen KA, Guzman DS, Knych HK, Petritz OA, Olsen GH, Paul-Murphy JR. Pharmacokinetics of buprenorphine hydrochloride following intramuscular and intravenous administration to American kestrels (Falco sparverius). Am J Vet Res. 2014 Aug; 75(8):711-5. PMID: 25061701.
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    85. Knych HK, Steffey EP, McKemie DS. Preliminary pharmacokinetics of morphine and its major metabolites following intravenous administration of four doses to horses. J Vet Pharmacol Ther. 2014 Aug; 37(4):374-81. PMID: 24479785.
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    86. Knych HK, Stanley SD, Arthur RM, Mitchell MM. Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Vet J. 2014 Nov; 46(6):734-8. PMID: 24393414.
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    87. Guedes AG, Knych HK, Soares JH, Brosnan RJ. Pharmacokinetics and physiological effects of repeated oral administrations of tramadol in horses. J Vet Pharmacol Ther. 2014 Jun; 37(3):269-78. PMID: 24180699.
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    88. Knych HK, Stanley SD. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse. Vet Anaesth Analg. 2014 Jan; 41(1):36-47. PMID: 24134603.
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    89. Knych HK, Mitchell MM, Steinmetz SJ, McKemie DS. Detection, pharmacokinetics and cardiac effects following administration of clenbuterol to exercised horses. Equine Vet J. 2014 May; 46(3):380-5. PMID: 23773115.
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    90. Knych HK, Harrison LM, Casbeer HC, McKemie DS. Disposition of methylprednisolone acetate in plasma, urine, and synovial fluid following intra-articular administration to exercised thoroughbred horses. J Vet Pharmacol Ther. 2014 Apr; 37(2):125-32. PMID: 23876165.
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    91. Knych HK, Vidal MA, Casbeer HC, McKemie DS. Pharmacokinetics of triamcinolone acetonide following intramuscular and intra-articular administration to exercised Thoroughbred horses. Equine Vet J. 2013 Nov; 45(6):715-20. PMID: 23574452.
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    92. Nieto JE, Maher O, Stanley SD, Knych HK, Snyder JR. Pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. Am J Vet Res. 2013 Apr; 74(4):550-6. PMID: 23531062.
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    93. Casbeer HC, Knych HK. Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. Vet J. 2013 Jun; 196(3):504-9. PMID: 23321455.
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    94. Knych HK, Corado CR, McKemie DS, Steffey EP. Pharmacokinetics and selected pharmacodynamic effects of tramadol following intravenous administration to the horse. Equine Vet J. 2013 Jul; 45(4):490-6. PMID: 23145962.
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    95. DiMaio Knych HK, Covarrubias V, Steffey EP. Effect of yohimbine on detomidine induced changes in behavior, cardiac and blood parameters in the horse. Vet Anaesth Analg. 2012 Nov; 39(6):574-83. PMID: 23035904.
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