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Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs. Biomaterials. 2022 09; 288:121701.
Seo JW, Ajenjo J, Wu B, Robinson E, Raie MN, Wang J, Tumbale SK, Buccino P, Anders DA, Shen B, Habte FG, Beinat C, James ML, Reyes ST, Ravindra Kumar S, Miles TF, Lee JT, Gradinaru V, Ferrara KW. PMID: 35985893; PMCID: PMC9621732.
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Cells
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In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift. Biomaterials. 2022 02; 281:121339.
Kheirolomoom A, Kare AJ, Ingham ES, Paulmurugan R, Robinson ER, Baikoghli M, Inayathullah M, Seo JW, Wang J, Fite BZ, Wu B, Tumbale SK, Raie MN, Cheng RH, Nichols L, Borowsky AD, Ferrara KW. PMID: 35078042; PMCID: PMC8892572.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice. Nucl Med Biol. 2021 Jul-Aug; 98-99:8-17.
Aghevlian S, Wu B, Raie MN, Tumbale SK, Kare AJ, Seo JW, Ferrara KW. PMID: 33962357; PMCID: PMC8486004.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun. 2020 04 30; 11(1):2102.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. PMID: 32355221; PMCID: PMC7193641.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Enhanced delivery of AAV-like nanoparticles after blood-brain barrier disruption in a mouse model. 2017 IEEE International Ultrasonics Symposium (IUS). 2019 Oct 1; 884-887.
Foiret FJ, Seo SJ, Zhang ZH, Kakwere KH, Mahakian ML, Tam TS, Ferrara FK. .
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A Scalable Method for Squalenoylation and Assembly of Multifunctional 64Cu-Labeled Squalenoylated Gemcitabine Nanoparticles. Nanotheranostics. 2018; 2(4):387-402.
Tucci ST, Seo JW, Kakwere H, Kheirolomoom A, Ingham ES, Mahakian LM, Tam S, Tumbale S, Baikoghli M, Cheng RH, Ferrara KW. PMID: 30324084; PMCID: PMC6170330.
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PubMed Mentions:
5 Fields:
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CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols. Clin Cancer Res. 2018 10 15; 24(20):4976-4987.
Seo JW, Tavaré R, Mahakian LM, Silvestrini MT, Tam S, Ingham ES, Salazar FB, Borowsky AD, Wu AM, Ferrara KW. PMID: 29967252; PMCID: PMC6215696.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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Dynamic contrast enhanced MRI detects changes in vascular transport rate constants following treatment with thermally-sensitive liposomal doxorubicin. J Control Release. 2017 06 28; 256:203-213.
Fite BZ, Kheirolomoom A, Foiret JL, Seo JW, Mahakian LM, Ingham ES, Tam SM, Borowsky AD, Curry FE, Ferrara KW. PMID: 28395970; PMCID: PMC5545100.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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2-Acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetrahydroisoquinoline exhibits anti-inflammatory properties and protects the nigral dopaminergic neurons. Eur J Pharmacol. 2016 Jan 15; 771:152-61.
Son HJ, Han SH, Lee JA, Lee CS, Seo JW, Chi DY, Hwang O. PMID: 26687634.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Ultrasound ablation enhances drug accumulation and survival in mammary carcinoma models. J Clin Invest. 2016 Jan; 126(1):99-111.
Wong AW, Fite BZ, Liu Y, Kheirolomoom A, Seo JW, Watson KD, Mahakian LM, Tam SM, Zhang H, Foiret J, Borowsky AD, Ferrara KW. PMID: 26595815; PMCID: PMC4701551.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Self-assembled 20-nm (64)Cu-micelles enhance accumulation in rat glioblastoma. J Control Release. 2015 Dec 28; 220(Pt A):51-60.
Seo JW, Ang J, Mahakian LM, Tam S, Fite B, Ingham ES, Beyer J, Forsayeth J, Bankiewicz KS, Xu T, Ferrara KW. PMID: 26437259; PMCID: PMC4688122.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice. ACS Nano. 2015 Sep 22; 9(9):8885-97.
Kheirolomoom A, Kim CW, Seo JW, Kumar S, Son DJ, Gagnon MK, Ingham ES, Ferrara KW, Jo H. PMID: 26308181; PMCID: PMC4581466.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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The pharmacokinetics of Zr-89 labeled liposomes over extended periods in a murine tumor model. Nucl Med Biol. 2015 Feb; 42(2):155-63.
Seo JW, Mahakian LM, Tam S, Qin S, Ingham ES, Meares CF, Ferrara KW. PMID: 25451215; PMCID: PMC4281498.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Effect of alkyl length of peptide-polymer amphiphile on cargo encapsulation stability and pharmacokinetics of 3-helix micelles. Biomacromolecules. 2014 Aug 11; 15(8):2963-70.
Dube N, Seo JW, Dong H, Shu JY, Lund R, Mahakian LM, Ferrara KW, Xu T. PMID: 24988250; PMCID: PMC4130244.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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AETIQ: a novel synthetic compound with anti-inflammatory properties in activated microglia. Inflammation. 2014 Jun; 37(3):766-74.
Son HJ, Shin N, Shin EJ, Chi DY, Seo JW, Lee CS, Hwang O. PMID: 24402420.
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AnimalsCells
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Comparison of PET imaging with 64Cu-liposomes and 18F-FDG in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch model of oral dysplasia and squamous cell carcinoma. Mol Imaging Biol. 2014 Apr; 16(2):284-92.
Mahakian LM, Farwell DG, Zhang H, Seo JW, Poirier B, Tinling SP, Afify AM, Haynam EM, Shaye D, Ferrara KW. PMID: 24019092; PMCID: PMC3984137.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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(64)Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic plaque. Bioconjug Chem. 2014 Feb 19; 25(2):231-9.
Seo JW, Baek H, Mahakian LM, Kusunose J, Hamzah J, Ruoslahti E, Ferrara KW. PMID: 24433095; PMCID: PMC4311647.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. J Control Release. 2013 Dec 28; 172(3):812-22.
Thorsen F, Fite B, Mahakian LM, Seo JW, Qin S, Harrison V, Johnson S, Ingham E, Caskey C, Sundstrøm T, Meade TJ, Harter PN, Skaftnesmo KO, Ferrara KW. PMID: 24161382; PMCID: PMC3922207.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
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Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers. Biomacromolecules. 2013 Oct 14; 14(10):3697-705.
Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T. PMID: 24050265; PMCID: PMC3923314.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Quantitation of nanoparticle accumulation in flow using optimized microfluidic chambers. J Drug Target. 2014 Jan; 22(1):48-56.
Kusunose J, Gagnon MK, Seo JW, Ferrara KW. PMID: 24079404; PMCID: PMC4004627.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Ann Biomed Eng. 2014 Feb; 42(2):280-98.
Qin S, Fite BZ, Gagnon MK, Seo JW, Curry FR, Thorsen F, Ferrara KW. PMID: 24018607; PMCID: PMC3943857.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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A phantom for visualization of three-dimensional drug release by ultrasound-induced mild hyperthermia. Med Phys. 2013 Aug; 40(8):083301.
Lai CY, Kruse D, Seo JW, Kheirolomoom A, Ferrara KW. PMID: 23927360; PMCID: PMC3739833.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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A comparison of image contrast with (64)Cu-labeled long circulating liposomes and (18)F-FDG in a murine model of mammary carcinoma. Am J Nucl Med Mol Imaging. 2013; 3(1):32-43.
Wong AW, Ormsby E, Zhang H, Seo JW, Mahakian LM, Caskey CF, Ferrara KW. PMID: 23342299; PMCID: PMC3545363.
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PubMed Mentions:
16
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The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nat Commun. 2013; 4:3000.
Son DJ, Kumar S, Takabe W, Kim CW, Ni CW, Alberts-Grill N, Jang IH, Kim S, Kim W, Won Kang S, Baker AH, Woong Seo J, Ferrara KW, Jo H. PMID: 24346612; PMCID: PMC3923891.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Long-circulating 15 nm micelles based on amphiphilic 3-helix peptide-PEG conjugates. ACS Nano. 2012 Jun 26; 6(6):5320-9.
Dong H, Dube N, Shu JY, Seo JW, Mahakian LM, Ferrara KW, Xu T. PMID: 22545944; PMCID: PMC3531550.
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PubMed Mentions:
26 Fields:
Translation:
Animals
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New synthetic method for benzofurans from 2-(cyanomethyl)phenyl derivatives. Tetrahedron. 2012 May 1; 68(21):3942-3947.
Kim KH, Seo SJ, Lee LM, Shin SD, Kim KH, Cho CH, Lee LB, Chi CD. .
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A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP. Br J Pharmacol. 2012 Apr; 165(7):2213-27.
Son HJ, Lee JA, Shin N, Choi JH, Seo JW, Chi DY, Lee CS, Kim EM, Choe H, Hwang O. PMID: 21951056; PMCID: PMC3413858.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors. Cancer Res. 2012 Mar 15; 72(6):1485-93.
Watson KD, Lai CY, Qin S, Kruse DE, Lin YC, Seo JW, Cardiff RD, Mahakian LM, Beegle J, Ingham ES, Curry FR, Reed RK, Ferrara KW. PMID: 22282664; PMCID: PMC3357123.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7154-9.
Hamzah J, Kotamraju VR, Seo JW, Agemy L, Fogal V, Mahakian LM, Peters D, Roth L, Gagnon MK, Ferrara KW, Ruoslahti E. PMID: 21482787; PMCID: PMC3084060.
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PubMed Mentions:
37 Fields:
Translation:
Animals
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Novel method to label solid lipid nanoparticles with 64cu for positron emission tomography imaging. Bioconjug Chem. 2011 Apr 20; 22(4):808-18.
Andreozzi E, Seo JW, Ferrara K, Louie A. PMID: 21388194; PMCID: PMC3086097.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Positron emission tomography imaging of the stability of Cu-64 labeled dipalmitoyl and distearoyl lipids in liposomes. J Control Release. 2011 Apr 10; 151(1):28-34.
Seo JW, Qin S, Mahakian LM, Watson KD, Kheirolomoom A, Ferrara KW. PMID: 21241753; PMCID: PMC3140766.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity. Mol Pharm. 2010 Dec 06; 7(6):1948-58.
Kheirolomoom A, Mahakian LM, Lai CY, Lindfors HA, Seo JW, Paoli EE, Watson KD, Haynam EM, Ingham ES, Xing L, Cheng RH, Borowsky AD, Cardiff RD, Ferrara KW. PMID: 20925429; PMCID: PMC3037269.
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PubMed Mentions:
30 Fields:
Translation:
Animals
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Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET. Clin Cancer Res. 2011 Feb 01; 17(3):550-9.
Rygh CB, Qin S, Seo JW, Mahakian LM, Zhang H, Adamson R, Chen JQ, Borowsky AD, Cardiff RD, Reed RK, Curry FR, Ferrara KW. PMID: 21106723; PMCID: PMC3107124.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Liposomal Cu-64 labeling method using bifunctional chelators: poly(ethylene glycol) spacer and chelator effects. Bioconjug Chem. 2010 Jul 21; 21(7):1206-15.
Seo JW, Mahakian LM, Kheirolomoom A, Zhang H, Meares CF, Ferdani R, Anderson CJ, Ferrara KW. PMID: 20568726; PMCID: PMC2943334.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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An imaging-driven model for liposomal stability and circulation. Mol Pharm. 2010 Feb 01; 7(1):12-21.
Qin S, Seo JW, Zhang H, Qi J, Curry FR, Ferrara KW. PMID: 19621944; PMCID: PMC2867051.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation. J Control Release. 2010 Apr 02; 143(1):13-22.
Paoli EE, Kruse DE, Seo JW, Zhang H, Kheirolomoom A, Watson KD, Chiu P, Stahlberg H, Ferrara KW. PMID: 20006659; PMCID: PMC2861564.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Imaging nanoparticle stability and activation in vivo. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:4580-1.
Ferrara KW, Seo JW, Zhang H. PMID: 19963843.
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Animals
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A novel method to label preformed liposomes with 64Cu for positron emission tomography (PET) imaging. Bioconjug Chem. 2008 Dec; 19(12):2577-84.
Seo JW, Zhang H, Kukis DL, Meares CF, Ferrara KW. PMID: 18991368; PMCID: PMC2756669.
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PubMed Mentions:
53 Fields:
Translation:
Animals
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Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model. Biomaterials. 2008 Apr; 29(12):1976-88.
Zhang H, Kusunose J, Kheirolomoom A, Seo JW, Qi J, Watson KD, Lindfors HA, Ruoslahti E, Sutcliffe JL, Ferrara KW. PMID: 18255141; PMCID: PMC2475513.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Convenient one-pot synthesis of 2,2-bis-(4-hydroxyphenyl)-cyclopentanone. J Org Chem. 2008 Jan 18; 73(2):715-8.
Seo JW, Kim HJ, Lee BS, Katzenellenbogen JA, Chi DY. PMID: 18088140.
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Translation:
Cells
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Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur J Med Chem. 2008 Jun; 43(6):1160-70.
Seo JW, Srisook E, Son HJ, Hwang O, Cha YN, Chi DY. PMID: 17980460.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds. Tetrahedron Letters. 2007 Jun 1; 48(23):3953-3957.
Sirion SU, Kim KH, Lee LJ, Seo SJ, Lee LB, Lee LS, Oh OS, Chi CD. .
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Synthesis and biodistribution of fluorine-18-labeled fluorocyclofenils for imaging the estrogen receptor. Nucl Med Biol. 2007 May; 34(4):383-90.
Seo JW, Chi DY, Dence CS, Welch MJ, Katzenellenbogen JA. PMID: 17499727; PMCID: PMC1948026.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer. J Med Chem. 2006 Apr 20; 49(8):2496-511.
Seo JW, Comninos JS, Chi DY, Kim DW, Carlson KE, Katzenellenbogen JA. PMID: 16610793; PMCID: PMC2522267.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide. Bioorg Med Chem Lett. 2005 Jul 15; 15(14):3369-73.
Seo JW, Srisook E, Son HJ, Hwang O, Cha YN, Chi DY. PMID: 15953725.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Hydroxylation of alkyl halides with water in ionic liquid: significantly enhanced nucleophilicity of water. J Org Chem. 2004 Apr 30; 69(9):3186-9.
Kim DW, Hong DJ, Seo JW, Kim HS, Kim HK, Song CE, Chi DY. PMID: 15104461.
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PubMed Mentions:
4 Fields:
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Syntheses and radical scavenging activities of resveratrol derivatives. Bioorg Med Chem Lett. 2004 Jan 19; 14(2):463-6.
Lee HJ, Seo JW, Lee BH, Chung KH, Chi DY. PMID: 14698182.
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PubMed Mentions:
4 Fields: