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Jerold A Last

Title(s)Professor, Pulmonary, Critical Care, and Sleep Medicine
SchoolUniversity of California, Davis
Phone530-752-6230
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    Collapse Research 
    Collapse Research Activities and Funding
    International Training Program in Environmental Toxicology and Public Health
    NIH/FIC D43TW005718Sep 29, 2001 - Feb 28, 2013
    Role: Principal Investigator
    LUNG COLLAGEN CROSSLINKING--BIOSYNTHESIS AND MATURATION
    NIH/NHLBI R01HL032690Apr 1, 1985 - Mar 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang DC, Li JM, Xu J, Oldham J, Phan SH, Last JA, Wu R, Chen CH. Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. FASEB J. 2019 Dec; 33(12):14354-14369. PMID: 31661644.
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    2. Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA. Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. J Immunol. 2018 06 01; 200(11):3840-3856. PMID: 29703864.
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    3. Cagle LA, Franzi LM, Linderholm AL, Last JA, Adams JY, Harper RW, Kenyon NJ. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS One. 2017; 12(11):e0187419. PMID: 29112971.
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    4. Cagle LA, Franzi LM, Epstein SE, Kass PH, Last JA, Kenyon NJ. Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol. Anesthesiol Res Pract. 2017; 2017:9161040. PMID: 28210272.
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    5. Franzi LM, Linderholm AL, Rabowsky M, Last JA. Lung toxicity in mice of airborne particulate matter from a modern layer hen facility containing Proposition 2-compliant animal caging. Toxicol Ind Health. 2017 Mar; 33(3):211-221. PMID: 26939833.
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    6. Zeki AA, Bratt JM, Chang KY, Franzi LM, Ott S, Silveria M, Fiehn O, Last JA, Kenyon NJ. Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins. Physiol Rep. 2015 May 11; 3(5). PMID: 25969462.
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    7. Zeki AA, Oldham J, Wilson M, Fortenko O, Goyal V, Last M, Last A, Patel A, Last JA, Kenyon NJ. Statin use and asthma control in patients with severe asthma. BMJ Open. 2013 Aug 13; 3(8). PMID: 23943778.
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    8. Morel N, Lassabe G, Elola S, Bondad M, Herrera S, Marí C, Last JA, Jensen O, Gonzalez-Sapienza G. A monoclonal antibody-based copro-ELISA kit for canine echinococcosis to support the PAHO effort for hydatid disease control in South America. PLoS Negl Trop Dis. 2013; 7(1):e1967. PMID: 23326610.
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    9. Pírez M, Gonzalez-Sapienza G, Sienra D, Ferrari G, Last M, Last JA, Brena BM. Limited analytical capacity for cyanotoxins in developing countries may hide serious environmental health problems: simple and affordable methods may be the answer. J Environ Manage. 2013 Jan 15; 114:63-71. PMID: 23220602.
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    10. Williams KM, Franzi LM, Last JA. Cell-specific oxidative stress and cytotoxicity after wildfire coarse particulate matter instillation into mouse lung. Toxicol Appl Pharmacol. 2013 Jan 01; 266(1):48-55. PMID: 23142465.
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    11. Rajal VB, Cid AG, Cruz MC, Poma HR, Cacciabue DG, Romano N, Moraga NB, Last JA. Increasing capacity for environmental engineering in Salta, Argentina. Am J Ind Med. 2013 Jan; 56(1):11-9. PMID: 22467330.
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    12. Franzi LM, Bratt JM, Williams KM, Last JA. Why is particulate matter produced by wildfires toxic to lung macrophages? Toxicol Appl Pharmacol. 2011 Dec 01; 257(2):182-8. PMID: 21945489.
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    13. Bratt JM, Zeki AA, Last JA, Kenyon NJ. Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma. J Biomed Res. 2011 Sep; 25(5):299-308. PMID: 23554705.
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    14. Tabares-da Rosa S, Rossotti M, Carleiza C, Carrión F, Pritsch O, Ahn KC, Last JA, Hammock BD, González-Sapienza G. Competitive selection from single domain antibody libraries allows isolation of high-affinity antihapten antibodies that are not favored in the llama immune response. Anal Chem. 2011 Sep 15; 83(18):7213-20. PMID: 21827167.
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    15. Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Transl Res. 2010 Dec; 156(6):335-49. PMID: 21078495.
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    16. Bratt JM, Williams K, Rabowsky MF, Last MS, Franzi LM, Last JA, Kenyon NJ. Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent. Mediators Inflamm. 2010; 2010. PMID: 20953358.
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    17. Rossotti MA, Carlomagno M, González-Techera A, Hammock BD, Last J, González-Sapienza G. Phage anti-immunocomplex assay for clomazone: two-site recognition increasing assay specificity and facilitating adaptation into an on-site format. Anal Chem. 2010 Nov 01; 82(21):8838-43. PMID: 20886819.
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    18. Wegesser TC, Franzi LM, Mitloehner FM, Eiguren-Fernandez A, Last JA. Lung antioxidant and cytokine responses to coarse and fine particulate matter from the great California wildfires of 2008. Inhal Toxicol. 2010 Jun; 22(7):561-70. PMID: 20388000.
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    19. Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):350-60. PMID: 20448054.
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    20. Carlomagno M, Mathó C, Cantou G, Sanborn JR, Last JA, Hammock BD, Roel A, González D, González-Sapienza G. A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture. J Agric Food Chem. 2010 Apr 14; 58(7):4367-71. PMID: 20302341.
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    21. Rajal VB, Cruz C, Last JA. Water quality issues and infant diarrhoea in a South American province. Glob Public Health. 2010; 5(4):348-63. PMID: 20473801.
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    22. Bratt JM, Franzi LM, Linderholm AL, O'Roark EM, Kenyon NJ, Last JA. Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2010 Jan 01; 242(1):1-8. PMID: 19800904.
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    23. Zeki AA, Franzi L, Last J, Kenyon NJ. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):731-40. PMID: 19608720.
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    24. Wegesser TC, Last JA. Mouse lung inflammation after instillation of particulate matter collected from a working dairy barn. Toxicol Appl Pharmacol. 2009 May 01; 236(3):348-57. PMID: 19272399.
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    25. Wegesser TC, Pinkerton KE, Last JA. California wildfires of 2008: coarse and fine particulate matter toxicity. Environ Health Perspect. 2009 Jun; 117(6):893-7. PMID: 19590679.
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    26. Bratt JM, Franzi LM, Linderholm AL, Last MS, Kenyon NJ, Last JA. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2009 Feb 01; 234(3):273-80. PMID: 19027033.
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    27. Trindade M, Nording M, Nichkova M, Spinnel E, Haglund P, Last MS, Gee S, Hammock B, Last JA, González-Sapienza G, Brena BM. Enzyme-linked immunosorbent assay for screening dioxin soil contamination by uncontrolled combustion during informal recycling in slums. Environ Toxicol Chem. 2008 Nov; 27(11):2224-32. PMID: 18522475.
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    28. Reigle KL, Di Lullo G, Turner KR, Last JA, Chervoneva I, Birk DE, Funderburgh JL, Elrod E, Germann MW, Surber C, Sanderson RD, San Antonio JD. Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesion. J Cell Biochem. 2008 Aug 01; 104(5):1684-98. PMID: 18348167.
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    29. González-Techera A, Umpiérrez-Failache M, Cardozo S, Obal G, Pritsch O, Last JA, Gee SJ, Hammock BD, González-Sapienza G. High-throughput method for ranking the affinity of peptide ligands selected from phage display libraries. Bioconjug Chem. 2008 May; 19(5):993-1000. PMID: 18393454.
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    30. Kenyon NJ, Bratt JM, Linderholm AL, Last MS, Last JA. Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol Appl Pharmacol. 2008 Aug 01; 230(3):269-75. PMID: 18439639.
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    31. Wegesser TC, Last JA. Lung response to coarse PM: bioassay in mice. Toxicol Appl Pharmacol. 2008 Jul 15; 230(2):159-66. PMID: 18384828.
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    32. González-Techera A, Kim HJ, Gee SJ, Last JA, Hammock BD, González-Sapienza G. Polyclonal antibody-based noncompetitive immunoassay for small analytes developed with short peptide loops isolated from phage libraries. Anal Chem. 2007 Dec 01; 79(23):9191-6. PMID: 17973501.
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    33. Ferraz N, Carnevia D, Nande G, Rossotti M, Miguez MN, Last JA, Gonzalez-Sapienza G. Specific immunoassays for endocrine disruptor monitoring using recombinant antigens cloned by degenerated primer PCR. Anal Bioanal Chem. 2007 Dec; 389(7-8):2195-202. PMID: 17922116.
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    34. González-Techera A, Vanrell L, Last JA, Hammock BD, González-Sapienza G. Phage anti-immune complex assay: general strategy for noncompetitive immunodetection of small molecules. Anal Chem. 2007 Oct 15; 79(20):7799-806. PMID: 17845007.
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    35. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol. 2007 Aug; 19(10):789-810. PMID: 17687713.
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    36. Mathrani VC, Kenyon NJ, Zeki A, Last JA. Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide? Curr Med Chem. 2007; 14(20):2204-13. PMID: 17691958.
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    37. Brena BM, Díaz L, Sienra D, Ferrari G, Ferraz N, Hellman U, Gonzalez-Sapienza G, Last JA. ITREOH building of regional capacity to monitor recreational water: development of a non-commercial microcystin ELISA and its impact on public health policy. Int J Occup Environ Health. 2006 Oct-Dec; 12(4):377-85. PMID: 17168226.
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    38. Kenyon NJ, Last MS, Eiserich JP, Morrissey BM, Temple LM, Last JA. Differentiation of the roles of NO from airway epithelium and inflammatory cells in ozone-induced lung inflammation. Toxicol Appl Pharmacol. 2006 Sep 15; 215(3):250-9. PMID: 16643973.
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    39. Lorenzo C, Last JA, González-Sapienza GG. The immunogenicity of Echinococcus granulosus antigen 5 is determined by its post-translational modifications. Parasitology. 2005 Nov; 131(Pt 5):669-77. PMID: 16255825.
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    40. Last JA, Gohil K, Mathrani VC, Kenyon NJ. Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicol Appl Pharmacol. 2005 Oct 15; 208(2):117-26. PMID: 16183385.
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    41. Cardozo S, González-Techera A, Last JA, Hammock BD, Kramer K, González-Sapienza GG. Analyte peptidomimetics selected from phage display peptide libraries: a systematic strategy for the development of environmental immunoassays. Environ Sci Technol. 2005 Jun 01; 39(11):4234-41. PMID: 15984805.
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    42. Lorenzo C, Ferreira HB, Monteiro KM, Rosenzvit M, Kamenetzky L, García HH, Vasquez Y, Naquira C, Sánchez E, Lorca M, Contreras M, Last JA, González-Sapienza GG. Comparative analysis of the diagnostic performance of six major Echinococcus granulosus antigens assessed in a double-blind, randomized multicenter study. J Clin Microbiol. 2005 Jun; 43(6):2764-70. PMID: 15956395.
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    43. Brena BM, Arellano L, Rufo C, Last MS, Montaño J, Egaña Cerni E, Gonzalez-Sapienza G, Last JA. ELISA as an affordable methodology for monitoring groundwater contamination by pesticides in low-income countries. Environ Sci Technol. 2005 Jun 01; 39(11):3896-903. PMID: 15984762.
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    44. Kenyon NJ, Last JA. Reversible and irreversible airway inflammation and fibrosis in mice exposed to inhaled ovalbumin. Inflamm Res. 2005 Feb; 54(2):57-65. PMID: 15750712.
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    45. Lee K, Smith JL, Last JA. Absence of respiratory inflammatory reaction of elemental sulfur using the California Pesticide Illness Database and a mouse model. J Agromedicine. 2005; 10(3):41-7. PMID: 16537315.
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    46. Ellahueñe MF, Pérez-Alzola LP, Farfán-Urzua M, González-Hormazabal P, Garay M, Olmedo MI, Last JA. Preliminary evaluation of DNA damage related with the smoking habit measured by the comet assay in whole blood cells. Cancer Epidemiol Biomarkers Prev. 2004 Jul; 13(7):1223-9. PMID: 15247134.
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    47. Last JA, Ward R, Temple L, Pinkerton KE, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles. Inhal Toxicol. 2004 Feb; 16(2):93-102. PMID: 15204782.
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    48. Rufo C, Hammock BD, Gee SJ, Last JA, González-Sapienza G. Robust and sensitive monoclonal enzyme-linked immunosorbent assay for the herbicide molinate. J Agric Food Chem. 2004 Jan 28; 52(2):182-7. PMID: 14733492.
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    49. Last JA, Ward R, Temple L, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. Inhal Toxicol. 2004 Jan; 16(1):33-43. PMID: 14744663.
      View in: PubMed
    50. Kenyon NJ, Ward RW, McGrew G, Last JA. TGF-beta1 causes airway fibrosis and increased collagen I and III mRNA in mice. Thorax. 2003 Sep; 58(9):772-7. PMID: 12947136.
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    51. Kenyon NJ, Gohil K, Last JA. Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences. Toxicol Appl Pharmacol. 2003 Aug 15; 191(1):2-11. PMID: 12915099.
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    52. Gohil K, Cross CE, Last JA. Ozone-induced disruptions of lung transcriptomes. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):719-28. PMID: 12763052.
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    53. Kenyon NJ, Ward RW, Last JA. Airway fibrosis in a mouse model of airway inflammation. Toxicol Appl Pharmacol. 2003 Jan 15; 186(2):90-100. PMID: 12639500.
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    54. Kenyon NJ, van der Vliet A, Schock BC, Okamoto T, McGrew GM, Last JA. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L540-5. PMID: 11839550.
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    55. Last JA. The missing link: the story of Karl Paul Link. Toxicol Sci. 2002 Mar; 66(1):4-6. PMID: 11861967.
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    56. Samimi A, Last JA. Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon. Toxicol Appl Pharmacol. 2001 Nov 01; 176(3):181-6. PMID: 11714250.
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    57. Samimi A, Last JA. Inhibition of lysyl hydroxylase by malathion and malaoxon. Toxicol Appl Pharmacol. 2001 May 01; 172(3):203-9. PMID: 11312648.
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    58. Last JA. A visitor's impressions of major environmental toxicity issues in the Mercosur. Toxicology. 2001 Jan 02; 156(2-3):175-8. PMID: 11243236.
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    59. Van Hoozen BE, Grimmer KL, Marelich GP, Armstrong LC, Last JA. Early phase collagen synthesis in lungs of rats exposed to bleomycin. Toxicology. 2000 May 19; 147(1):1-13. PMID: 10837927.
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    60. Wu R, Zhao YH, Plopper CG, Chang MM, Chmiel K, Cross JJ, Weir A, Last JA, Tarkington B. Differential expression of stress proteins in nonhuman primate lung and conducting airway after ozone exposure. Am J Physiol. 1999 09; 277(3):L511-22. PMID: 10484458.
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    61. Farman CA, Watkins K, van Hoozen B, Last JA, Witschi H, Pinkerton KE. Centriacinar remodeling and sustained procollagen gene expression after exposure to ozone and nitrogen dioxide. Am J Respir Cell Mol Biol. 1999 Feb; 20(2):303-11. PMID: 9922222.
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    62. Goldkorn T, Balaban N, Matsukuma K, Chea V, Gould R, Last J, Chan C, Chavez C. EGF-Receptor phosphorylation and signaling are targeted by H2O2 redox stress. Am J Respir Cell Mol Biol. 1998 Nov; 19(5):786-98. PMID: 9806743.
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    63. Last JA, Pinkerton KE. Chronic exposure of rats to ozone and sulfuric acid aerosol: biochemical and structural responses. Toxicology. 1997 Jan 15; 116(1-3):133-46. PMID: 9020514.
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    64. Reiser K, Summers P, Medrano JF, Rucker R, Last J, McDonald R. Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice. Am J Physiol. 1996 Sep; 271(3 Pt 2):R696-703. PMID: 8853393.
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    65. Gerriets JE, Reiser KM, Last JA. Lung collagen cross-links in rats with experimentally induced pulmonary fibrosis. Biochim Biophys Acta. 1996 Jun 07; 1316(2):121-31. PMID: 8672549.
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    66. Armstrong LC, Last JA. Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system. Biochim Biophys Acta. 1995 Oct 17; 1264(1):93-102. PMID: 7578263.
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    67. Sun W, Wu R, Last JA. Effects of exposure to environmental tobacco smoke on a human tracheobronchial epithelial cell line. Toxicology. 1995 Jun 26; 100(1-3):163-74. PMID: 7624873.
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    68. Costa DL, Tepper JS, Stevens MA, Watkinson WP, Doerfler DL, Gelzleichter TR, Last JA. Restrictive lung disease in rats exposed chronically to an urban profile of ozone. Am J Respir Crit Care Med. 1995 May; 151(5):1512-8. PMID: 7735608.
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    69. Catalano PJ, Chang LY, Harkema JR, Kaden DA, Last JA, Mellick PW, Parks WC, Pinkerton KE, Radhakrishnamurthy B, Ryan LM. Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XI: Integrative Summary. Res Rep Health Eff Inst. 1995 Apr; (65 Pt 11):1-54; discussion 55-85. PMID: 7598833.
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    70. O'Neill CA, van der Vliet A, Eiserich JP, Last JA, Halliwell B, Cross CE. Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid. Biochem Soc Symp. 1995; 61:139-52. PMID: 8660391.
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    71. Last JA, Sun WM, Witschi H. Ozone, NO, and NO2: oxidant air pollutants and more. Environ Health Perspect. 1994 Dec; 102 Suppl 10:179-84. PMID: 7705295.
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    72. Birnbaum SC, Kien N, Martucci RW, Gelzleichter TR, Witschi H, Hendrickx AG, Last JA. Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat. Toxicology. 1994 Nov-Dec; 94(1-3):69-80. PMID: 7801331.
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    73. Armstrong LC, Watkins K, Pinkerton KE, Last JA. Collagen mRNA content and distribution in the lungs of rats exposed to ozone. Am J Respir Cell Mol Biol. 1994 Jul; 11(1):25-34. PMID: 8018336.
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    74. Sun W, Wu R, Last JA. Coordinated expression of a 45 kD protein and ozone toxicity in a human bronchial epithelial cell line. Am J Respir Cell Mol Biol. 1994 Jun; 10(6):673-82. PMID: 7516174.
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    75. Witschi H, Lundgaard SM, Rajini P, Hendrickx AG, Last JA. Effects of exposure to nicotine and to sidestream smoke on pregnancy outcome in rats. Toxicol Lett. 1994 May; 71(3):279-86. PMID: 8160216.
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    76. Rajini P, Last JA, Pinkerton KE, Hendrickx AG, Witschi H. Decreased fetal weights in rats exposed to sidestream cigarette smoke. Fundam Appl Toxicol. 1994 Apr; 22(3):400-4. PMID: 8050635.
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    77. Last JA, Gelzleichter TR, Harkema J, Hawk S. Consequences of prolonged inhalation of ozone on Fischer-344/N rats: collaborative studies. Part I: Content and cross-linking of lung collagen. Res Rep Health Eff Inst. 1994 Apr; (65):1-29; discussion 31-40. PMID: 8037892.
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    78. Tarkington BK, Wu R, Sun WM, Nikula KJ, Wilson DW, Last JA. In vitro exposure of tracheobronchial epithelial cells and of tracheal explants to ozone. Toxicology. 1994 Mar 11; 88(1-3):51-68. PMID: 8160205.
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    79. Tarkington BK, Duvall TR, Last JA. Ozone exposure of cultured cells and tissues. Methods Enzymol. 1994; 234:257-65. PMID: 7808293.
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    80. Gerriets JE, Curwin SL, Last JA. Tendon hypertrophy is associated with increased hydroxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen. J Biol Chem. 1993 Dec 05; 268(34):25553-60. PMID: 8244992.
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    81. Last JA, Gelzleichter T, Harkema J, Parks WC, Mellick P. Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats. Toxicology. 1993 Nov 12; 84(1-3):83-102. PMID: 8266340.
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    82. Rajini P, Gelzleichter TR, Last JA, Witschi H. Airway epithelial labeling index as an indicator of ozone induced lung injury. Toxicology. 1993 Oct 25; 83(1-3):159-68. PMID: 8248943.
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    83. Last JA, Gelzleichter TR, Pinkerton KE, Walker RM, Witschi H. A new model of progressive pulmonary fibrosis in rats. Am Rev Respir Dis. 1993 Aug; 148(2):487-94. PMID: 8342914.
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    84. Rajini P, Gelzleichter TR, Last JA, Witschi H. Alveolar and airway cell kinetics in the lungs of rats exposed to nitrogen dioxide, ozone, and a combination of the two gases. Toxicol Appl Pharmacol. 1993 Aug; 121(2):186-92. PMID: 8346535.
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    85. Reiser KM, Amigable MA, Last JA. Nonenzymatic glycation of type I collagen. The effects of aging on preferential glycation sites. J Biol Chem. 1992 Dec 05; 267(34):24207-16. PMID: 1447170.
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    86. Gelzleichter TR, Witschi H, Last JA. Synergistic interaction of nitrogen dioxide and ozone on rat lungs: acute responses. Toxicol Appl Pharmacol. 1992 Sep; 116(1):1-9. PMID: 1529441.
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    87. Gelzleichter TR, Witschi H, Last JA. Concentration-response relationships of rat lungs to exposure to oxidant air pollutants: a critical test of Haber's Law for ozone and nitrogen dioxide. Toxicol Appl Pharmacol. 1992 Jan; 112(1):73-80. PMID: 1733050.
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    88. Last JA. Global atmospheric change: potential health effects of acid aerosol and oxidant gas mixtures. Environ Health Perspect. 1991 Dec; 96:151-7. PMID: 1820258.
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    89. Chen J, Armstrong LC, Liu SJ, Gerriets JE, Last JA. Silica increases cytosolic free calcium ion concentration of alveolar macrophages in vitro. Toxicol Appl Pharmacol. 1991 Nov; 111(2):211-20. PMID: 1659754.
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    90. Last JA, Gerriets JE, Armstrong LG, Gelzleichter TR, Reiser KM. Hydroxylation of collagen by lungs of rats administered bleomycin. Chest. 1991 Mar; 99(3 Suppl):70S. PMID: 1705202.
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    91. Last JA. Synergistic effects of air pollutants: ozone plus a respirable aerosol. Res Rep Health Eff Inst. 1991 Jan; (38):1-32; discussion 33-43. PMID: 2012683.
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    92. Wu R, Martin WR, Robinson CB, St George JA, Plopper CG, Kurland G, Last JA, Cross CE, McDonald RJ, Boucher R. Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Am J Respir Cell Mol Biol. 1990 Nov; 3(5):467-78. PMID: 2223101.
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    93. Last JA, Gerriets JE, Armstrong LC, Gelzleichter TR, Reiser KM. Hydroxylation of collagen by lungs of rats administered bleomycin. Am J Respir Cell Mol Biol. 1990 Jun; 2(6):543-8. PMID: 1693282.
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    94. Last JA, King TE, Nerlich AG, Reiser KM. Collagen cross-linking in adult patients with acute and chronic fibrotic lung disease. Molecular markers for fibrotic collagen. Am Rev Respir Dis. 1990 Feb; 141(2):307-13. PMID: 2301849.
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    95. Last JA, Armstrong LG, Reiser KM. Biosynthesis of collagen crosslinks. Int J Biochem. 1990; 22(6):559-64. PMID: 2199250.
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    96. Last JA, Reiser KM. Biosynthesis of collagen crosslinks. III. In vivo labeling and stability of lung collagen in rats with bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 1989 Aug; 1(2):111-7. PMID: 2482779.
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    97. Last JA, Summers P, Reiser KM. Biosynthesis of collagen crosslinks. II. In vivo labelling and stability of lung collagen in rats. Biochim Biophys Acta. 1989 Feb 24; 990(2):182-9. PMID: 2492830.
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    98. Last JA. Effects of inhaled acids on lung biochemistry. Environ Health Perspect. 1989 Feb; 79:115-9. PMID: 2707190.
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    99. Warren DL, Hyde DM, Last JA. Synergistic interaction of ozone and respirable aerosols on rat lungs. IV. Protection by quenchers of reactive oxygen species. Toxicology. 1988 Dec 16; 53(1):113-33. PMID: 3144057.
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    100. Tyler WS, Tyler NK, Last JA, Gillespie MJ, Barstow TJ. Comparison of daily and seasonal exposures of young monkeys to ozone. Toxicology. 1988 Jul; 50(2):131-44. PMID: 3388434.
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    101. Reiser KM, Hennessy SM, Last JA. Analysis of age-associated changes in collagen crosslinking in the skin and lung in monkeys and rats. Biochim Biophys Acta. 1987 Dec 07; 926(3):339-48. PMID: 3120785.
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    102. Tyler WS, Tyler NK, Last JA, Barstow TJ, Magliano DJ, Hinds DM. Effects of ozone on lung and somatic growth. Pair fed rats after ozone exposure and recovery periods. Toxicology. 1987 Oct 12; 46(1):1-20. PMID: 3660417.
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    103. Last JA, Warren DL. Synergistic interaction between nitrogen dioxide and respirable aerosols of sulfuric acid or sodium chloride on rat lungs. Toxicol Appl Pharmacol. 1987 Aug; 90(1):34-42. PMID: 3629590.
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    104. Reiser KM, Tyler WS, Hennessy SM, Dominguez JJ, Last JA. Long-term consequences of exposure to ozone. II. Structural alterations in lung collagen of monkeys. Toxicol Appl Pharmacol. 1987 Jul; 89(3):314-22. PMID: 3603563.
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    105. Warren DL, Last JA. Synergistic interaction of ozone and respirable aerosols on rat lungs. III. Ozone and sulfuric acid aerosol. Toxicol Appl Pharmacol. 1987 Apr; 88(2):203-16. PMID: 3564039.
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    106. Reiser KM, Last JA. A molecular marker for fibrotic collagen in lungs of infants with respiratory distress syndrome. Biochem Med Metab Biol. 1987 Feb; 37(1):16-21. PMID: 3566976.
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    107. Last JA, Warren DL, Pecquet-Goad E, Witschi H. Modification by ozone of lung tumor development in mice. J Natl Cancer Inst. 1987 Jan; 78(1):149-54. PMID: 3467123.
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    108. Reiser KM, Last JA. Collagen crosslinking in lungs of rats with experimental silicosis. Coll Relat Res. 1986 Oct; 6(4):313-23. PMID: 3816140.
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    109. Guth DJ, Warren DL, Last JA. Comparative sensitivity of measurements of lung damage made by bronchoalveolar lavage after short-term exposure of rats to ozone. Toxicology. 1986 Aug; 40(2):131-43. PMID: 3726890.
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    110. Warren DL, Guth DJ, Last JA. Synergistic interaction of ozone and respirable aerosols on rat lungs. II. Synergy between ammonium sulfate aerosol and various concentrations of ozone. Toxicol Appl Pharmacol. 1986 Jul; 84(3):470-9. PMID: 3726870.
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    111. Last JA, Hyde DM, Guth DJ, Warren DL. Synergistic interaction of ozone and respirable aerosols on rat lungs. I. Importance of aerosol acidity. Toxicology. 1986 Jun; 39(3):247-57. PMID: 3705087.
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    112. Geismar LS, Hennessey S, Reiser KM, Last JA. D-penicillamine prevents collagen accumulation in lungs of rats given bleomycin. Chest. 1986 Mar; 89(3 Suppl):153S-154S. PMID: 2419048.
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    113. Reiser KM, Tryka AF, Lindenschmidt RC, Last JA, Witschi HR. Changes in collagen cross-linking in bleomycin-induced pulmonary fibrosis. J Biochem Toxicol. 1986 Mar; 1(1):83-91. PMID: 2482891.
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    114. Reiser KM, Last JA. Biosynthesis of collagen crosslinks: in vivo labelling of neonatal skin, tendon, and bone in rats. Connect Tissue Res. 1986; 14(4):293-306. PMID: 2938883.
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    115. Reiser KM, Last JA. Early cellular events in pulmonary fibrosis. Exp Lung Res. 1986; 10(4):331-55. PMID: 3522217.
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    116. Myers BA, Dubick MA, Gerriets JE, Reiser KM, Last JA, Rucker RB. Lung collagen and elastin after ozone exposure in vitamin B-6-deficient rats. Toxicol Lett. 1986 Jan; 30(1):55-61. PMID: 3952773.
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    117. Last JA, Reiser KM. Effects of silica on lung collagen. Ciba Found Symp. 1986; 121:180-93. PMID: 2427284.
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    118. Cross CE, Warren D, Gerriets JE, Wilson DW, Halliwell B, Last JA. Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats. J Lab Clin Med. 1985 Oct; 106(4):433-8. PMID: 2413151.
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    119. Last JA. Changes in the collagen pathway in fibrosis. Fundam Appl Toxicol. 1985 Apr; 5(2):210-8. PMID: 3886468.
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    120. Hyde DM, Plopper CG, Weir AJ, Murnane RD, Warren DL, Last JA, Pepelko WE. Peribronchiolar fibrosis in lungs of cats chronically exposed to diesel exhaust. Lab Invest. 1985 Feb; 52(2):195-206. PMID: 2578585.
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    121. Critchfield JW, Dubick M, Last J, Cross CE, Rucker RB. Changes in response to ascorbic acid administered orally to rat pups: lung collagen, elastin and protein synthesis. J Nutr. 1985 Jan; 115(1):70-7. PMID: 3965669.
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    122. Shoemaker CT, Reiser KM, Goetzman BW, Last JA. Elevated ratios of type I/III collagen in the lungs of chronically ventilated neonates with respiratory distress. Pediatr Res. 1984 Nov; 18(11):1176-80. PMID: 6514444.
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    123. Myers BA, Dubick MA, Reiser KM, Gerriets JE, Last JA, Rucker RB. Ozone exposure, food restriction and protein deficiency: changes in collagen and elastin in rodent lung. Toxicol Lett. 1984 Oct; 23(1):43-9. PMID: 6485017.
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    124. Last JA, Reiser KM. Collagen biosynthesis. Environ Health Perspect. 1984 Apr; 55:169-77. PMID: 6428877.
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    125. Last JA, Hyde DM, Chang DP. A mechanism of synergistic lung damage by ozone and a respirable aerosol. Exp Lung Res. 1984; 7(3-4):223-35. PMID: 6525988.
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    126. Last JA, Reiser KM, Tyler WS, Rucker RB. Long-term consequences of exposure to ozone. I. Lung collagen content. Toxicol Appl Pharmacol. 1984 Jan; 72(1):111-8. PMID: 6710477.
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    127. Myers B, Dubick M, Last JA, Rucker RB. Elastin synthesis during perinatal lung development in the rat. Biochim Biophys Acta. 1983 Nov 22; 761(1):17-22. PMID: 6639962.
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    128. Myers BA, Dubick MA, Gerreits J, Rucker RB, Jackson AC, Reiser KM, Williams SM, Last JA. Protein deficiency: effects on lung mechanics and the accumulation of collagen and elastin in rat lung. J Nutr. 1983 Nov; 113(11):2308-15. PMID: 6631548.
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    129. Last JA. Biochemical alterations of lung structure as predictors of chronic lung disease. Environ Health Perspect. 1983 Oct; 52:159-63. PMID: 6653517.
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    130. Last JA, Gerriets JE, Hyde DM. Synergistic effects on rat lungs of mixtures of oxidant air pollutants (ozone or nitrogen dioxide) and respirable aerosols. Am Rev Respir Dis. 1983 Sep; 128(3):539-44. PMID: 6614649.
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    131. Dubick MA, Critchfield JW, Last JA, Cross CE, Rucker RB. Ascorbic acid turnover in the mouse following acute ozone exposure. Toxicology. 1983 Jul-Aug; 27(3-4):301-13. PMID: 6623478.
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    132. Koenig WJ, Cross CE, Hesterberg TW, Last JA. The smoking gun. Mechanism of methylprednisolone prevention of bleomycin-induced pulmonary fibrosis. Chest. 1983 May; 83(5 Suppl):5S-7S. PMID: 6188583.
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    133. Last JA, Siefkin AD, Reiser KM. Type I collagen content is increased in lungs of patients with adult respiratory distress syndrome. Thorax. 1983 May; 38(5):364-8. PMID: 6879485.
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    134. Reiser KM, Last JA. Type V collagen. Quantitation in normal lungs and in lungs of rats with bleomycin-induced pulmonary fibrosis. J Biol Chem. 1983 Jan 10; 258(1):269-75. PMID: 6184372.
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    135. Reiser KM, Haschek WM, Hesterberg TW, Last JA. Experimental silicosis. II. Long-term effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs. Am J Pathol. 1983 Jan; 110(1):30-40. PMID: 6295174.
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    136. Dubick MA, Last JA, Cross CE, Rucker RB. Interactions of ascorbic acid supplementation and bleomycin instillation on murine lung connective tissue metabolism. Drug Nutr Interact. 1983; 2(2):105-15. PMID: 6205840.
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    137. Haschek WM, Reiser KM, Klein-Szanto AJ, Kehrer JP, Smith LH, Last JA, Witschi HP. Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen. Cell kinetics and collagen metabolism. Am Rev Respir Dis. 1983 Jan; 127(1):28-34. PMID: 6849545.
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    138. Reiser KM, Last JA. Anomalous electrophoretic behavior of a cyanogen bromide peptide from type III collagen. Connect Tissue Res. 1983; 12(1):1-16. PMID: 6671378.
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    139. Frates RC, Kaizu TT, Last JA. Mucus glycoproteins secreted by respiratory epithelial tissue from cystic fibrosis patients. Pediatr Res. 1983 Jan; 17(1):30-4. PMID: 6835712.
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    140. Reiser KM, Hesterberg TW, Haschek WM, Last JA. Experimental silicosis. I. Acute effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs. Am J Pathol. 1982 May; 107(2):176-85. PMID: 7081382.
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    141. Haschek WM, Klein-Szanto AJ, Last JA, Reiser KM, Witschi H. Long-term morphologic and biochemical features of experimentally induced lung fibrosis in the mouse. Lab Invest. 1982 Apr; 46(4):438-49. PMID: 7070057.
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    142. Last JA, Dasgupta PK, DeCesare K, Tarkington BK. Inhalation toxicology of ammonium persulfate, an oxidant aerosol, in rats. Toxicol Appl Pharmacol. 1982 Apr; 63(2):257-63. PMID: 7089974.
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    143. Raabe OG, Tyler WS, Last JA, Schwartz LW, Lollini LO, Fisher GL, Wilson FD, Dungworth DL. Studies of the chronic inhalation of coal fly ash by rats. Ann Occup Hyg. 1982; 26(1-4):189-211. PMID: 7181265.
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    144. Last JA, Hesterberg TW, Reiser KM, Cross CE, Amis TC, Gunn C, Steffey EP, Grandy J, Henrickson R. Ozone-induced alterations in collagen metabolism of monkey lungs: use of biopsy-obtained lung tissue. Toxicol Appl Pharmacol. 1981 Sep 30; 60(3):579-85. PMID: 7292495.
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    145. Hesterberg TW, Gerriets JE, Reiser KM, Jackson AC, Cross CE, Last JA. Bleomycin-induced pulmonary fibrosis: correlation of biochemical, physiological, and histological changes. Toxicol Appl Pharmacol. 1981 Sep 15; 60(2):360-7. PMID: 6169174.
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    146. Cross CE, Hesterberg TW, Reiser KM, Last JA. Ozone toxicity as a model of lung fibrosis. Chest. 1981 Jul; 80(1 Suppl):52-4. PMID: 7249741.
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    147. Fedullo AJ. Prevention of increased rates of collagen synthesis by methylprednisolone. Am Rev Respir Dis. 1981 Jun; 123(6):697-8. PMID: 7271074.
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    148. Dubick MA, Rucker RB, Last JA, Lollini LO, Cross CE. Elastin turnover in murine lung after repeated ozone exposure. Toxicol Appl Pharmacol. 1981 Apr; 58(2):203-10. PMID: 7245196.
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    149. Dubick MA, Rucker RB, Cross CE, Last JA. Elastin metabolism in rodent lung. Biochim Biophys Acta. 1981 Feb 05; 672(3):303-6. PMID: 7213816.
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    150. Hesterberg TW, Last JA. Ozone-induced acute pulmonary fibrosis in rats. Prevention of increased rates of collagen synthesis by methylprednisolone. Am Rev Respir Dis. 1981 Jan; 123(1):47-52. PMID: 7458086.
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    151. Reiser KM, Last JA. Pulmonary fibrosis in experimental acute respiratory disease. Am Rev Respir Dis. 1981 Jan; 123(1):58-63. PMID: 6161575.
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    152. Last JA, Dasgupta PK, Etchison JR. Inhalation toxicology of sodium sulfite aerosols in rats. Toxicol Appl Pharmacol. 1980 Sep 15; 55(2):299-34. PMID: 6158767.
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    153. Last JA, Greenberg DB. Ozone-induced alterations in collagen metabolism of rat lungs II. Long-term exposures. Toxicol Appl Pharmacol. 1980 Aug; 55(1):108-14. PMID: 7423497.
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    154. Last JA, Kaizu T, Mossman BT. Glycoprotein synthesis by an established cell line from hamster tracheal epithelium. Exp Lung Res. 1980 Jun; 1(2):89-98. PMID: 7227345.
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    155. Reiser KM, Last JA. Quantitation of specific collagen types from lungs of small mammals. Anal Biochem. 1980 May 01; 104(1):87-98. PMID: 7386885.
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    156. Last JA, Kaizu T. Mucus glycoprotein secretion by tracheal explants: effects of pollutants. Environ Health Perspect. 1980 Apr; 35:131-7. PMID: 7408795.
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    157. Graham DR. Treatment of cryptococcal meningitis. N Engl J Med. 1979 Dec 27; 301(26):1451. PMID: 514334.
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    158. Last JA, Greenberg DB, Castleman WL. Ozone-induced alterations in collagen metabolism of rat lungs. Toxicol Appl Pharmacol. 1979 Nov; 51(2):247-58. PMID: 531890.
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    159. Reiser KM, Last JA. Silicosis and fibrogenesis: fact and artifact. Toxicology. 1979 May; 13(1):51-72. PMID: 229587.
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    160. Last JA, Raabe OG, Moore PF, Tarkington BK. Chromate inhibition of metabolism by rat tracheal explants. II. In vivo exposures. Toxicol Appl Pharmacol. 1979 Feb; 47(2):313-22. PMID: 452024.
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    161. Kaizu T, Lyons SA, Cross CE, Jennings MD, Last JA. Composition of glycoproteins secreted by tracheal explants from various animal species. Comp Biochem Physiol B. 1979; 62(3):195-200. PMID: 45551.
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    162. Greenberg DB, Lyons SA, Last JA. Paraquat-induced changes in the rate of collagen biosynthesis by rat lung explants. J Lab Clin Med. 1978 Dec; 92(6):1033-42. PMID: 739165.
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    163. Cross CE, Last JA. Paraquat goes to pot. Chest. 1978 Oct; 74(4):358-9. PMID: 699640.
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    164. Greenberg DB, Reiser KM, Last JA. Correlation of biochemical and morphologic manifestations of acute pulmonary fibrosis in rats administered paraquat. Chest. 1978 Oct; 74(4):421-5. PMID: 699655.
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    165. Last JA, Cross CE. A new model for health effects of air pollutants: evidence for synergistic effects of mixtures of ozone and sulfuric acid aerosols on rat lungs. J Lab Clin Med. 1978 Feb; 91(2):328-39. PMID: 621431.
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    166. Last JA, Jennings MD, Schwartz LW, Cross CE. Glycoprotein secretion by tracheal explants cultured from rats exposed to ozone. Am Rev Respir Dis. 1977 Oct; 116(4):695-703. PMID: 921053.
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    167. Last JA, Jennings ME, Moore PF. Chromate inhibition of metabolism by rat tracheal explants. Lab Invest. 1977 Sep; 37(3):276-9. PMID: 895069.
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    168. Cross CE, Last JA. Lack of correlation between glutathione peroxidase activities and slsceptibility to O2 toxicity in rat lungs. Res Commun Chem Pathol Pharmacol. 1977 Jul; 17(3):433-46. PMID: 897337.
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    169. Sninsky JJ, Last JA, Gilham PT. The use of terminal blocking groups for the specific joining of oligonucleotides in RNA ligase reactions containing equimolar concentrations of acceptor and donor molecules. Nucleic Acids Res. 1976 Nov; 3(11):3157-66. PMID: 1005114.
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    170. Varricchio F, Last JA. Transfer RNA of a collagen producing tissue, chick-embryo calvaria. Mol Biol Rep. 1976 Jul; 2(6):465-70. PMID: 986543.
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    171. Last JA, Anderson WF. Purification and properties of bacteriophage T4-induced RNA ligase. Arch Biochem Biophys. 1976 May; 174(1):167-76. PMID: 938049.
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    172. Last JA, Baer J, Millson C. Site of hydrolysis of collagen by hot trichloroacetic acid. Connect Tissue Res. 1976; 4(3):149-53. PMID: 134865.
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    173. Boedtker H, Crkvenjakov RB, Last JA, Doty P. The identification of collagen messenger RNA. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):4208-12. PMID: 4530295.
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    174. Barker JE, Last JA, Adams SL, Nienhuis AW, Anderson WF. Hemogloblin switching in sheep and goats: erythropoietin-dependent synthesis of hemoglobin C in goat bone-marrow cultures. Proc Natl Acad Sci U S A. 1973 Jun; 70(6):1739-43. PMID: 4515932.
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    175. Laskin AI, Last JA. Tetracyclines. Antibiot Chemother (1971). 1971; 17:1-28. PMID: 4950998.
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    176. Neidleman SL, Pan SC, Last JA, Dolfini JE. Chemical conversion of desacetylcephalothin lactone into desacetylcephalothin. The final link in a total synthesis of cephalosporanic acid derivatives. J Med Chem. 1970 May; 13(3):386-8. PMID: 5441127.
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    177. Parker WL, Aklonis C, Last JA. Bromal, the product of reaction of aspartic acid with N-bromosuccinimide. Experientia. 1970 Mar 15; 26(3):242-3. PMID: 4984734.
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    178. Last JA. Studies on the binding of tetracycline to ribosomes. Biochim Biophys Acta. 1969 Dec 16; 195(2):506-14. PMID: 4904394.
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    179. Last JA, Izaki K, Snell JF. The resistance of Escherichia coli to oxytetracycline. Can J Microbiol. 1969 Sep; 15(9):1077-83. PMID: 4906192.
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    180. Von Saltza MH, Last JA, Stapleton PG, Rathnum ML, Neidleman SL. Cyanomycin, its identity with pyocyanine. J Antibiot (Tokyo). 1969 Feb; 22(2):49-54. PMID: 4977004.
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    181. Last JA, Izaki K, Snell JF. Some effects of various tetracyclines on incorporation of amino acids into polypeptides by Escherichia coli extracts. Biochim Biophys Acta. 1969 Jan 21; 174(1):400-2. PMID: 4885697.
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    182. Last JA, Stanley WM, Salas M, Hille MB, Wahba AJ, Ochoa S. Translation of the genetic message, IV. UAA as a chain termination codon. Proc Natl Acad Sci U S A. 1967 Apr; 57(4):1062-7. PMID: 5231346.
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    183. Last JA, Shell JF. Microbiological transformation of oxytetracycline. Nature. 1966 Aug 27; 211(5052):1002-3. PMID: 5338766.
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    184. Stanley WM, Smith MA, Hille MB, Last JA. Studies on the genetic message. I. Preparation of oligonucleotide messengers of specified base sequence. Cold Spring Harb Symp Quant Biol. 1966; 31:99-102. PMID: 5237215.
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    185. Golub EE, Marble SJ, Meister A. Conversion of aminoacyl soluble RNA derivatives to the corresponding amino alcohols. Biochim Biophys Acta. 1965 Jul 15; 103(3):536-9. PMID: 5853500.
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    186. Last JA, Izaki K, Snell JF. The failure of tetracycline to bind to Escherichia coli ribosomes. Biochim Biophys Acta. 1965 Jul 15; 103(3):532-4. PMID: 5322494.
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