Jerold A Last

Title(s)Professor, Pulmonary, Critical Care, and Sleep Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    International Training Program in Environmental Toxicology and Public Health
    NIH/FIC D43TW005718Sep 29, 2001 - Feb 28, 2013
    Role: Principal Investigator
    NIH/NHLBI R01HL032690Apr 1, 1985 - Mar 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA. Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. J Immunol. 2018 Jun 01; 200(11):3840-3856. PMID: 29703864.
      View in: PubMed
    2. Cagle LA, Franzi LM, Linderholm AL, Last JA, Adams JY, Harper RW, Kenyon NJ. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS One. 2017; 12(11):e0187419. PMID: 29112971.
      View in: PubMed
    3. Cagle LA, Franzi LM, Epstein SE, Kass PH, Last JA, Kenyon NJ. Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol. Anesthesiol Res Pract. 2017; 2017:9161040. PMID: 28210272.
      View in: PubMed
    4. Franzi LM, Linderholm AL, Rabowsky M, Last JA. Lung toxicity in mice of airborne particulate matter from a modern layer hen facility containing Proposition 2-compliant animal caging. Toxicol Ind Health. 2017 Mar; 33(3):211-221. PMID: 26939833.
      View in: PubMed
    5. Zeki AA, Bratt JM, Chang KY, Franzi LM, Ott S, Silveria M, Fiehn O, Last JA, Kenyon NJ. Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins. Physiol Rep. 2015 May 11; 3(5). PMID: 25969462; PMCID: PMC4463814.
    6. Zeki AA, Oldham J, Wilson M, Fortenko O, Goyal V, Last M, Last A, Patel A, Last JA, Kenyon NJ. Statin use and asthma control in patients with severe asthma. BMJ Open. 2013 Aug 13; 3(8). PMID: 23943778.
      View in: PubMed
    7. Williams KM, Franzi LM, Last JA. Cell-specific oxidative stress and cytotoxicity after wildfire coarse particulate matter instillation into mouse lung. Toxicol Appl Pharmacol. 2013 Jan 01; 266(1):48-55. PMID: 23142465; PMCID: PMC3546532.
    8. Franzi LM, Bratt JM, Williams KM, Last JA. Why is particulate matter produced by wildfires toxic to lung macrophages? Toxicol Appl Pharmacol. 2011 Dec 01; 257(2):182-8. PMID: 21945489; PMCID: PMC3221783.
    9. Bratt JM, Zeki AA, Last JA, Kenyon NJ. Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma. J Biomed Res. 2011 Sep; 25(5):299-308. PMID: 23554705; PMCID: PMC3596726.
    10. Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Transl Res. 2010 Dec; 156(6):335-49. PMID: 21078495; PMCID: PMC2990975.
    11. Bratt JM, Williams K, Rabowsky MF, Last MS, Franzi LM, Last JA, Kenyon NJ. Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent. Mediators Inflamm. 2010; 2010. PMID: 20953358; PMCID: PMC2952819.
    12. Wegesser TC, Franzi LM, Mitloehner FM, Eiguren-Fernandez A, Last JA. Lung antioxidant and cytokine responses to coarse and fine particulate matter from the great California wildfires of 2008. Inhal Toxicol. 2010 Jun; 22(7):561-70. PMID: 20388000.
      View in: PubMed
    13. Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):350-60. PMID: 20448054; PMCID: PMC3095936.
    14. Bratt JM, Franzi LM, Linderholm AL, O'Roark EM, Kenyon NJ, Last JA. Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2010 Jan 01; 242(1):1-8. PMID: 19800904; PMCID: PMC3221650.
    15. Zeki AA, Franzi L, Last J, Kenyon NJ. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):731-40. PMID: 19608720; PMCID: PMC2778150.
    16. Wegesser TC, Last JA. Mouse lung inflammation after instillation of particulate matter collected from a working dairy barn. Toxicol Appl Pharmacol. 2009 May 01; 236(3):348-57. PMID: 19272399; PMCID: PMC2680696.
    17. Wegesser TC, Pinkerton KE, Last JA. California wildfires of 2008: coarse and fine particulate matter toxicity. Environ Health Perspect. 2009 Jun; 117(6):893-7. PMID: 19590679; PMCID: PMC2702402.
    18. Bratt JM, Franzi LM, Linderholm AL, Last MS, Kenyon NJ, Last JA. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2009 Feb 01; 234(3):273-80. PMID: 19027033; PMCID: PMC2666129.
    19. Kenyon NJ, Bratt JM, Linderholm AL, Last MS, Last JA. Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol Appl Pharmacol. 2008 Aug 01; 230(3):269-75. PMID: 18439639; PMCID: PMC2578817.
    20. Wegesser TC, Last JA. Lung response to coarse PM: bioassay in mice. Toxicol Appl Pharmacol. 2008 Jul 15; 230(2):159-66. PMID: 18384828; PMCID: PMC2517986.
    21. Kenyon NJ, Last MS, Eiserich JP, Morrissey BM, Temple LM, Last JA. Differentiation of the roles of NO from airway epithelium and inflammatory cells in ozone-induced lung inflammation. Toxicol Appl Pharmacol. 2006 Sep 15; 215(3):250-9. PMID: 16643973; PMCID: PMC1594585.
    22. Last JA, Gohil K, Mathrani VC, Kenyon NJ. Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicol Appl Pharmacol. 2005 Oct 15; 208(2):117-26. PMID: 16183385.
      View in: PubMed
    23. Lee K, Smith JL, Last JA. Absence of respiratory inflammatory reaction of elemental sulfur using the California Pesticide Illness Database and a mouse model. J Agromedicine. 2005; 10(3):41-7. PMID: 16537315.
      View in: PubMed
    24. Last JA, Ward R, Temple L, Pinkerton KE, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles. Inhal Toxicol. 2004 Feb; 16(2):93-102. PMID: 15204782.
      View in: PubMed
    25. Last JA, Ward R, Temple L, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. Inhal Toxicol. 2004 Jan; 16(1):33-43. PMID: 14744663.
      View in: PubMed
    26. Kenyon NJ, Gohil K, Last JA. Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences. Toxicol Appl Pharmacol. 2003 Aug 15; 191(1):2-11. PMID: 12915099.
      View in: PubMed
    27. Gohil K, Cross CE, Last JA. Ozone-induced disruptions of lung transcriptomes. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):719-28. PMID: 12763052.
      View in: PubMed
    28. Kenyon NJ, Ward RW, Last JA. Airway fibrosis in a mouse model of airway inflammation. Toxicol Appl Pharmacol. 2003 Jan 15; 186(2):90-100. PMID: 12639500.
      View in: PubMed
    29. Last JA. The missing link: the story of Karl Paul Link. Toxicol Sci. 2002 Mar; 66(1):4-6. PMID: 11861967.
      View in: PubMed
    30. Kenyon NJ, van der Vliet A, Schock BC, Okamoto T, McGrew GM, Last JA. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L540-5. PMID: 11839550.
      View in: PubMed
    31. Last JA. A visitor's impressions of major environmental toxicity issues in the Mercosur. Toxicology. 2001 Jan 02; 156(2-3):175-8. PMID: 11243236.
      View in: PubMed
    32. Last JA, Pinkerton KE. Chronic exposure of rats to ozone and sulfuric acid aerosol: biochemical and structural responses. Toxicology. 1997 Jan 15; 116(1-3):133-46. PMID: 9020514.
      View in: PubMed