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Jonathan K Leach

Title(s)Administrator, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone559-688-1731
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    1. Harvestine JN, Saiz Jr AM, Leach JK. Cell-secreted extracellular matrix influences cellular composition sequestered from unprocessed bone marrow aspirate for osteogenic grafts. Biomater Sci. 2019 Apr 23; 7(5):2091-2101. PMID: 30869662.
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    2. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. Non-destructive detection of matrix stabilization correlates with enhanced mechanical properties of self-assembled articular cartilage. J Tissue Eng Regen Med. 2019 Apr; 13(4):637-648. PMID: 30770656.
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    3. Ingavle GC, Gionet-Gonzales M, Vorwald CE, Bohannon LK, Clark K, Galuppo LD, Leach JK. Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model. Biomaterials. 2019 Mar; 197:119-128. PMID: 30641263.
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    4. Zhou X, Haudenschild AK, Sherlock BE, Hu JC, Leach JK, Athanasiou KA, Marcu L. Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging. J Biomed Opt. 2018 Dec; 23(12):1-8. PMID: 30578627.
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    5. Zhang J, Whitehead J, Liu Y, Yang Q, Leach JK, Liu GY. Direct Observation of Tunneling Nanotubes within Human Mesenchymal Stem Cell Spheroids. J Phys Chem B. 2018 Nov 01; 122(43):9920-9926. PMID: 30350968.
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    6. Hung BP, Harvestine JN, Saiz AM, Gonzalez-Fernandez T, Sahar DE, Weiss ML, Leach JK. Defining hydrogel properties to instruct lineage- and cell-specific mesenchymal differentiation. Biomaterials. 2019 Jan; 189:1-10. PMID: 30384124.
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    7. Arumugasaamy N, Navarro J, Kent Leach J, Kim PCW, Fisher JP. In Vitro Models for Studying Transport Across Epithelial Tissue Barriers. Ann Biomed Eng. 2019 Jan; 47(1):1-21. PMID: 30218224.
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    8. Mitra D, Yasui OW, Harvestine JN, Link JM, Hu JC, Athanasiou KA, Leach JK. Exogenous Lysyl Oxidase-Like 2 and Perfusion Culture Induce Collagen Crosslink Formation in Osteogenic Grafts. Biotechnol J. 2019 Mar; 14(3):e1700763. PMID: 30052320.
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    9. Haudenschild AK, Sherlock BE, Zhou X, Hu JC, Leach JK, Marcu L, Athanasiou KA. Nondestructive fluorescence lifetime imaging and time-resolved fluorescence spectroscopy detect cartilage matrix depletion and correlate with mechanical properties. Eur Cell Mater. 2018 07 27; 36:30-43. PMID: 30051455.
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    10. Gionet-Gonzales MA, Leach JK. Engineering principles for guiding spheroid function in the regeneration of bone, cartilage, and skin. Biomed Mater. 2018 03 21; 13(3):034109. PMID: 29460842.
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    11. Sherlock BE, Harvestine JN, Mitra D, Haudenschild A, Hu J, Athanasiou KA, Leach JK, Marcu L. Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging. J Biomed Opt. 2018 Mar; 23(3):1-9. PMID: 29512359.
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    12. Vorwald CE, Ho SS, Whitehead J, Leach JK. High-Throughput Formation of Mesenchymal Stem Cell Spheroids and Entrapment in Alginate Hydrogels. Methods Mol Biol. 2018; 1758:139-149. PMID: 29679328.
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    13. Ho SS, Keown AT, Addison B, Leach JK. Cell Migration and Bone Formation from Mesenchymal Stem Cell Spheroids in Alginate Hydrogels Are Regulated by Adhesive Ligand Density. Biomacromolecules. 2017 Dec 11; 18(12):4331-4340. PMID: 29131587.
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    14. Murphy KC, Whitehead J, Zhou D, Ho SS, Leach JK. Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids. Acta Biomater. 2017 12; 64:176-186. PMID: 28987783.
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    15. Orbay H, Busse B, Leach JK, Sahar DE. The Effects of Adipose-Derived Stem Cells Differentiated Into Endothelial Cells and Osteoblasts on Healing of Critical Size Calvarial Defects. J Craniofac Surg. 2017 Oct; 28(7):1874-1879. PMID: 28872512.
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    16. Mitra D, Whitehead J, Yasui OW, Leach JK. Bioreactor culture duration of engineered constructs influences bone formation by mesenchymal stem cells. Biomaterials. 2017 Nov; 146:29-39. PMID: 28898756.
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    17. Liu Y, Liu J, Fite BZ, Foiret J, Ilovitsh A, Leach JK, Dumont E, Caskey CF, Ferrara KW. Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity. Phys Med Biol. 2017 05 21; 62(10):4083-4106. PMID: 28426437.
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    18. Murphy KC, Whitehead J, Falahee PC, Zhou D, Simon SI, Leach JK. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids. Stem Cells. 2017 06; 35(6):1493-1504. PMID: 28276602.
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    19. Murphy KC, Hung BP, Browne-Bourne S, Zhou D, Yeung J, Genetos DC, Leach JK. Measurement of oxygen tension within mesenchymal stem cell spheroids. J R Soc Interface. 2017 02; 14(127). PMID: 28179546.
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    20. Harvestine JN, Vollmer NL, Ho SS, Zikry CA, Lee MA, Leach JK. Extracellular Matrix-Coated Composite Scaffolds Promote Mesenchymal Stem Cell Persistence and Osteogenesis. Biomacromolecules. 2016 11 14; 17(11):3524-3531. PMID: 27744699.
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    21. Thummala AS, Leach JK, Patterson E, O'Rear EA. Effect of encapsulation on plasminogen activator delivery to the microcirculation and its implications for bleeding. Clin Hemorheol Microcirc. 2016 Oct 05; 63(4):373-379. PMID: 26890102.
      View in: PubMed
    22. Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA, Leach JK. Bone Morphogenetic Protein-2 Promotes Human Mesenchymal Stem Cell Survival and Resultant Bone Formation When Entrapped in Photocrosslinked Alginate Hydrogels. Adv Healthc Mater. 2016 10; 5(19):2501-2509. PMID: 27581621.
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    23. Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. Binding to COMP Reduces the BMP2 Dose for Spinal Fusion in a Rat Model. Spine (Phila Pa 1976). 2016 Jul 15; 41(14):E829-36. PMID: 26679888.
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    24. Murphy KC, Hoch AI, Harvestine JN, Zhou D, Leach JK. Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through a2ß1 Signaling. Stem Cells Transl Med. 2016 09; 5(9):1229-37. PMID: 27365484.
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    25. Ho SS, Murphy KC, Binder BY, Vissers CB, Leach JK. Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels. Stem Cells Transl Med. 2016 Jun; 5(6):773-81. PMID: 27057004.
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    26. Hoch AI, Mittal V, Mitra D, Vollmer N, Zikry CA, Leach JK. Cell-secreted matrices perpetuate the bone-forming phenotype of differentiated mesenchymal stem cells. Biomaterials. 2016 Jan; 74:178-87. PMID: 26457835.
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    27. Murphy KC, Stilhano RS, Mitra D, Zhou D, Batarni S, Silva EA, Leach JK. Hydrogel biophysical properties instruct coculture-mediated osteogenic potential. FASEB J. 2016 Jan; 30(1):477-86. PMID: 26443826.
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    28. Binder BY, Williams PA, Silva EA, Leach JK. Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. Tissue Eng Part B Rev. 2015 Dec; 21(6):531-42. PMID: 26035484.
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    29. Binder BY, Sagun JE, Leach JK. Reduced serum and hypoxic culture conditions enhance the osteogenic potential of human mesenchymal stem cells. Stem Cell Rev. 2015 Jun; 11(3):387-93. PMID: 25173881.
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    30. Murphy KC, Hughbanks ML, Binder BY, Vissers CB, Leach JK. Engineered Fibrin Gels for Parallel Stimulation of Mesenchymal Stem Cell Proangiogenic and Osteogenic Potential. Ann Biomed Eng. 2015 Aug; 43(8):2010-21. PMID: 25527322.
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    31. Mejía Oneto JM, Gupta M, Leach JK, Lee M, Sutcliffe JL. Implantable biomaterial based on click chemistry for targeting small molecules. Acta Biomater. 2014 Dec; 10(12):5099-5105. PMID: 25162537.
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    32. Murphy KC, Fang SY, Leach JK. Human mesenchymal stem cell spheroids in fibrin hydrogels exhibit improved cell survival and potential for bone healing. Cell Tissue Res. 2014 Jul; 357(1):91-9. PMID: 24781147; PMCID: PMC4077909.
      View in: PubMed, PubMed Central
    33. Textor JA, Murphy KC, Leach JK, Tablin F. Ultrastructure and growth factor content of equine platelet-rich fibrin gels. Am J Vet Res. 2014 Apr; 75(4):392-401. PMID: 24669926.
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    34. Hoch AI, Leach JK. Concise review: optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applications. Stem Cells Transl Med. 2014 May; 3(5):643-52. PMID: 24682286.
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    35. Man AJ, Leach JK, Bannerman P. Redirection of neurite outgrowth by coupling chondroitin sulfate proteoglycans to polymer membranes. Ann Biomed Eng. 2014 Jun; 42(6):1271-81. PMID: 24570390.
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    36. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102(12):4480-90. PMID: 24616346; PMCID: PMC4145060.
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    37. Binder BY, Genetos DC, Leach JK. Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis. Tissue Eng Part A. 2014 Apr; 20(7-8):1156-64. PMID: 24131310; PMCID: PMC3993074.
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    38. Jose S, Hughbanks ML, Binder BY, Ingavle GC, Leach JK. Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels. Acta Biomater. 2014 May; 10(5):1955-64. PMID: 24468583.
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    39. Binder BY, Sondergaard CS, Nolta JA, Leach JK. Lysophosphatidic acid enhances stromal cell-directed angiogenesis. PLoS One. 2013; 8(12):e82134. PMID: 24312635.
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    40. Ingavle GC, Leach JK. Advancements in electrospinning of polymeric nanofibrous scaffolds for tissue engineering. Tissue Eng Part B Rev. 2014 Aug; 20(4):277-93. PMID: 24004443.
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    41. Bhat A, Hoch AI, Decaris ML, Leach JK. Alginate hydrogels containing cell-interactive beads for bone formation. FASEB J. 2013 Dec; 27(12):4844-52. PMID: 24005905.
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    42. Soicher MA, Christiansen BA, Stover SM, Leach JK, Fyhrie DP. Remineralization of demineralized bone matrix (DBM) via alternating solution immersion (ASI). J Mech Behav Biomed Mater. 2013 Oct; 26:109-18. PMID: 23759125; PMCID: PMC3713112.
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    43. Davis HE, Binder BY, Schaecher P, Yakoobinsky DD, Bhat A, Leach JK. Enhancing osteoconductivity of fibrin gels with apatite-coated polymer microspheres. Tissue Eng Part A. 2013 Aug; 19(15-16):1773-82. PMID: 23560390; PMCID: PMC3700018.
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    44. Murphy KC, Leach JK. A reproducible, high throughput method for fabricating fibrin gels. BMC Res Notes. 2012 Aug 08; 5:423. PMID: 22873708.
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    45. Decaris ML, Binder BY, Soicher MA, Bhat A, Leach JK. Cell-derived matrix coatings for polymeric scaffolds. Tissue Eng Part A. 2012 Oct; 18(19-20):2148-57. PMID: 22651377.
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    46. He J, Decaris ML, Leach JK. Bioceramic-mediated trophic factor secretion by mesenchymal stem cells enhances in vitro endothelial cell persistence and in vivo angiogenesis. Tissue Eng Part A. 2012 Jul; 18(13-14):1520-8. PMID: 22546052.
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    47. Hoch AI, Binder BY, Genetos DC, Leach JK. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One. 2012; 7(4):e35579. PMID: 22536411; PMCID: PMC3334972.
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    48. Decaris ML, Mojadedi A, Bhat A, Leach JK. Transferable cell-secreted extracellular matrices enhance osteogenic differentiation. Acta Biomater. 2012 Feb; 8(2):744-52. PMID: 22079209.
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    49. Bhat A, Boyadjiev SA, Senders CW, Leach JK. Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior. PLoS One. 2011; 6(10):e25990. PMID: 21998741.
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    50. Man AJ, Davis HE, Itoh A, Leach JK, Bannerman P. Neurite outgrowth in fibrin gels is regulated by substrate stiffness. Tissue Eng Part A. 2011 Dec; 17(23-24):2931-42. PMID: 21882895.
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    51. Wong ML, Leach JK, Athanasiou KA, Griffiths LG. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011 Nov; 32(32):8129-38. PMID: 21810537.
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    52. Davis HE, Case EM, Miller SL, Genetos DC, Leach JK. Osteogenic response to BMP-2 of hMSCs grown on apatite-coated scaffolds. Biotechnol Bioeng. 2011 Nov; 108(11):2727-35. PMID: 21656707; PMCID: PMC3178749.
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    53. Fite BZ, Decaris M, Sun Y, Sun Y, Lam A, Ho CK, Leach JK, Marcu L. Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging. Tissue Eng Part C Methods. 2011 Apr; 17(4):495-504. PMID: 21303258; PMCID: PMC3065732.
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    54. Decaris ML, Leach JK. Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation. Ann Biomed Eng. 2011 Apr; 39(4):1174-85. PMID: 21120695.
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    55. Toupadakis CA, Wong A, Genetos DC, Cheung WK, Borjesson DL, Ferraro GL, Galuppo LD, Leach JK, Owens SD, Yellowley CE. Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am J Vet Res. 2010 Oct; 71(10):1237-45. PMID: 20919913.
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    56. Davis HE, Miller SL, Case EM, Leach JK. Supplementation of fibrin gels with sodium chloride enhances physical properties and ensuing osteogenic response. Acta Biomater. 2011 Feb; 7(2):691-9. PMID: 20837168.
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    57. Rao RR, He J, Leach JK. Biomineralized composite substrates increase gene expression with nonviral delivery. J Biomed Mater Res A. 2010 Aug; 94(2):344-54. PMID: 20186740.
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    58. Davis HE, Leach JK. Designing bioactive delivery systems for tissue regeneration. Ann Biomed Eng. 2011 Jan; 39(1):1-13. PMID: 20676773; PMCID: PMC3010216.
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    59. Cheung WK, Working DM, Galuppo LD, Leach JK. Osteogenic comparison of expanded and uncultured adipose stromal cells. Cytotherapy. 2010 Jul; 12(4):554-62. PMID: 20370353.
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    60. He J, Genetos DC, Yellowley CE, Leach JK. Oxygen tension differentially influences osteogenic differentiation of human adipose stem cells in 2D and 3D cultures. J Cell Biochem. 2010 May; 110(1):87-96. PMID: 20213746.
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    61. Genetos DC, Cheung WK, Decaris ML, Leach JK. Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF. J Mol Neurosci. 2010 Mar; 40(3):360-6. PMID: 20107925; PMCID: PMC2825316.
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    62. He J, Genetos DC, Leach JK. Osteogenesis and trophic factor secretion are influenced by the composition of hydroxyapatite/poly(lactide-co-glycolide) composite scaffolds. Tissue Eng Part A. 2010 Jan; 16(1):127-37. PMID: 19642853; PMCID: PMC2811060.
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    63. Davis HE, Rao RR, He J, Leach JK. Biomimetic scaffolds fabricated from apatite-coated polymer microspheres. J Biomed Mater Res A. 2009 Sep 15; 90(4):1021-31. PMID: 18655148.
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    64. Leu A, Stieger SM, Dayton P, Ferrara KW, Leach JK. Angiogenic response to bioactive glass promotes bone healing in an irradiated calvarial defect. Tissue Eng Part A. 2009 Apr; 15(4):877-85. PMID: 18795867.
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    65. Decaris ML, Lee CI, Yoder MC, Tarantal AF, Leach JK. Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells. Angiogenesis. 2009; 12(4):303-11. PMID: 19544080.
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    66. Rocha FG, Sundback CA, Krebs NJ, Leach JK, Mooney DJ, Ashley SW, Vacanti JP, Whang EE. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials. 2008 Jul; 29(19):2884-90. PMID: 18396329.
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    67. Leach JK, Mooney DJ. Synthetic extracellular matrices for tissue engineering. Pharm Res. 2008 May; 25(5):1209-11. PMID: 18266090.
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    68. Leu A, Leach JK. Proangiogenic potential of a collagen/bioactive glass substrate. Pharm Res. 2008 May; 25(5):1222-9. PMID: 18049878.
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    69. Riddle KW, Kong HJ, Leach JK, Fischbach C, Cheung C, Anseth KS, Mooney DJ. Modifying the proliferative state of target cells to control DNA expression and identifying cell types transfected in vivo. Mol Ther. 2007 Feb; 15(2):361-8. PMID: 17235315.
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    70. Sedrakyan S, Zhou ZY, Perin L, Leach K, Mooney D, Kim TH. Tissue engineering of a small hand phalanx with a porously casted polylactic acid-polyglycolic acid copolymer. Tissue Eng. 2006 Sep; 12(9):2675-83. PMID: 16995801.
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    71. Leach JK. Multifunctional cell-instructive materials for tissue regeneration. Regen Med. 2006 Jul; 1(4):447-55. PMID: 17465837.
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    72. Leach JK, Kaigler D, Wang Z, Krebsbach PH, Mooney DJ. Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials. 2006 Jun; 27(17):3249-55. PMID: 16490250.
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    73. Kong HJ, Liu J, Riddle K, Matsumoto T, Leach K, Mooney DJ. Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat Mater. 2005 Jun; 4(6):460-4. PMID: 15895097.
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    74. Leach JK, Patterson E, O'Rear EA. Distributed intraclot thrombolysis: mechanism of accelerated thrombolysis with encapsulated plasminogen activators. J Thromb Haemost. 2004 Sep; 2(9):1548-55. PMID: 15333029.
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    75. Leach JK, Mooney DJ. Bone engineering by controlled delivery of osteoinductive molecules and cells. Expert Opin Biol Ther. 2004 Jul; 4(7):1015-27. PMID: 15268670.
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    76. Leach JK, Patterson E, O'Rear EA. Encapsulation of a plasminogen activator speeds reperfusion, lessens infarct and reduces blood loss in a canine model of coronary artery thrombosis. Thromb Haemost. 2004 Jun; 91(6):1213-8. PMID: 15175809.
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    77. Leach JK, Patterson E, O'Rear EA. Improving thrombolysis with encapsulated plasminogen activators and clinical relevance to myocardial infarction and stroke. Clin Hemorheol Microcirc. 2004; 30(3-4):225-8. PMID: 15258347.
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    78. Leach JK, O'Rear EA, Patterson E, Miao Y, Johnson AE. Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. Thromb Haemost. 2003 Jul; 90(1):64-70. PMID: 12876627.
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    79. Thummala AS, Leach JK, O'Rear EA. Factors affecting the particle size and in vitro release of bovine serum albumin from polyethylene glycol microparticles. Biomed Sci Instrum. 2003; 39:318-23. PMID: 12724913.
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    80. Leach JK, Hinman A, O'Rear EA. Investigation of deformability, viscosity, and aggregation of mPEG-modified erythrocytes. Biomed Sci Instrum. 2002; 38:333-8. PMID: 12085627.
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