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John C Rutledge, MD

Title(s)Professor, Cardiovascular Medicine
SchoolUniversity of California, Davis
AddressHousestaff Building (UCD Med Center)
CA 95817
Phone916-734-1516
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Intramuscular Lipids in Muscle Anabolic Resistance
    NIH/NIAMS R01AR070031Apr 1, 2016 - Mar 31, 2021
    Role: Co-Principal Investigator
    Role of lipid droplets in neurovascular inflammation
    NIH/NIA R01AG045541Sep 15, 2014 - May 31, 2019
    Role: Principal Investigator
    Brain Microvascular Determinants of Alzheimers Disease
    NIH/NIA R01AG039094Aug 15, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Imaging Lipoprotein-Endothelial Cell Interactions
    NIH/NHLBI R01HL078615Sep 22, 2004 - Aug 31, 2008
    Role: Principal Investigator
    Effects of a high glycemic load diet on vascular system
    NIH/NHLBI R01HL071488Sep 30, 2002 - Aug 31, 2005
    Role: Principal Investigator
    Interactions of Lipoproteins with the Vascular Wall
    NIH/NHLBI R01HL055667Aug 1, 1996 - Aug 31, 2012
    Role: Principal Investigator
    EXTRACELLULAR TRANSPORT OF LOW DENSITY LIPOPROTEIN
    NIH/NHLBI K11HL002112Aug 1, 1990 - Jul 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Lipotoxic Injury Differentially Regulates Brain Microvascular Gene Expression in Male Mice. Nutrients. 2020 Jun 13; 12(6). Nuthikattu S, Milenkovic D, Rutledge JC, Villablanca AC. PMID: 32545722.
      View in: PubMed   Mentions:    Fields:    
    2. Endotoxin May Not Be the Major Cause of Postprandial Inflammation in Adults Who Consume a Single High-Fat or Moderately High-Fat Meal. J Nutr. 2020 May 01; 150(5):1303-1312. Mo Z, Huang S, Burnett DJ, Rutledge JC, Hwang DH. PMID: 32040591.
      View in: PubMed   Mentions:    Fields:    
    3. The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice. Sci Rep. 2019 12 13; 9(1):19058. Nuthikattu S, Milenkovic D, Rutledge J, Villablanca A. PMID: 31836762.
      View in: PubMed   Mentions: 1     Fields:    
    4. Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury. Free Radic Biol Med. 2019 11 01; 143:25-46. Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss JC, Wilson DW, Rutledge JC, Aung HH. PMID: 31356870.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Inhibition of perilipin 2 expression reduces pro-inflammatory gene expression and increases lipid droplet size. Food Funct. 2018 Dec 13; 9(12):6245-6256. Norman JE, Aung HH, Wilson DW, Rutledge JC. PMID: 30402637.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice. Food Funct. 2018 Feb 21; 9(2):1187-1198. Yokoyama AS, Dunaway K, Rutkowsky J, Rutledge JC, Milenkovic D. PMID: 29372223.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet. PLoS One. 2018; 13(2):e0191909. Rutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC. PMID: 29444171.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review. Curr Pharm Des. 2018; 24(17):1827-1831. Norman JE, Rutkowsky J, Bodine S, Rutledge JC. PMID: 29623829.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. High-Intensity Statin Therapy Is Associated With Improved Survival in Patients With Peripheral Artery Disease. J Am Heart Assoc. 2017 07 15; 6(7). Foley TR, Singh GD, Kokkinidis DG, Choy HK, Pham T, Amsterdam EA, Rutledge JC, Waldo SW, Armstrong EJ, Laird JR. PMID: 28711864.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. DNA methylation alterations in Alzheimer's disease. Environ Epigenet. 2017 May; 3(2):dvx008. Yokoyama AS, Rutledge JC, Medici V. PMID: 29492310.
      View in: PubMed   Mentions:
    11. Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C500-C516. Lee LL, Aung HH, Wilson DW, Anderson SE, Rutledge JC, Rutkowsky JM. PMID: 28077357.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline. Am J Neurodegener Dis. 2016; 5(5):171-177. Wang M, Norman JE, Srinivasan VJ, Rutledge JC. PMID: 28078193.
      View in: PubMed   Mentions:
    13. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Nov; 11(11):804-818. Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. PMID: 27611852.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial. J Nutr. 2016 07; 146(7):1411-9. Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, Bonnel EL, Woodhouse LR, Zunino SJ, Peerson JM, Lee JY, Rutledge JC, Hwang DH. PMID: 27306892.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res. 2016 06; 57(6):955-68. Aung HH, Altman R, Nyunt T, Kim J, Nuthikattu S, Budamagunta M, Voss JC, Wilson D, Rutledge JC, Villablanca AC. PMID: 27087439.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice. Metab Syndr Relat Disord. 2016 May; 14(4):202-9. Syed R, Shibata NM, Kharbanda KK, Su RJ, Olson K, Yokoyama A, Rutledge JC, Chmiel KJ, Kim K, Halsted CH, Medici V. PMID: 26881897.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-ß Receptor Pathway in Human Aortic Endothelial Cells. PLoS One. 2015; 10(12):e0145523. Eiselein L, Nyunt T, Lamé MW, Ng KF, Wilson DW, Rutledge JC, Aung HH. PMID: 26709509.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med. 2016 10; 76(4):1246-51. Ng KF, Anderson S, Mayo P, Aung HH, Walton JH, Rutledge JC. PMID: 26485349.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):479-82. Walton JH, Ng KF, Anderson SE, Rutledge JC. PMID: 25998382.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys. 2014 Oct 21; 16(39):21595-21601. Yahiatène I, Aung HH, Wilson DW, Rutledge JC. PMID: 25189785.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. A systems biology analysis of brain microvascular endothelial cell lipotoxicity. BMC Syst Biol. 2014 Jul 04; 8:80. Aung HH, Tsoukalas A, Rutledge JC, Tagkopoulos I. PMID: 24993133.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. The Postprandial Effects of a Moderately High-Fat Meal on Lipid Profiles and Vascular Inflammation in Alzheimer's Disease Patients: A Pilot Study. J Gen Pract (Los Angel). 2014; 2(6). Altman R, Keenan AH, Newman JW, Rutledge JC. PMID: 26029731.
      View in: PubMed   Mentions:
    23. Postprandial VLDL lipolysis products increase monocyte adhesion and lipid droplet formation via activation of ERK2 and NF?B. Am J Physiol Heart Circ Physiol. 2014 Jan 01; 306(1):H109-20. den Hartigh LJ, Altman R, Norman JE, Rutledge JC. PMID: 24163071.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. Coronary artery revascularization in patients with diabetes mellitus. Circulation. 2013 Oct 08; 128(15):1675-85. Armstrong EJ, Rutledge JC, Rogers JH. PMID: 24100481.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    25. Inflammasome-mediated secretion of IL-1ß in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol. 2013 Oct 15; 191(8):4337-47. Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH. PMID: 24043885.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    26. Global T-wave inversions with isolated hypomagnesemia. J Emerg Med. 2013 Oct; 45(4):e107-11. Tsai TF, Browning AC, Rutledge J. PMID: 23896055.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Induction of ATF3 gene network by triglyceride-rich lipoprotein lipolysis products increases vascular apoptosis and inflammation. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2088-96. Aung HH, Lame MW, Gohil K, An CI, Wilson DW, Rutledge JC. PMID: 23868936.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    28. Testosterone-derived estradiol production by male endothelium is robust and dependent on p450 aromatase via estrogen receptor alpha. Springerplus. 2013 Dec; 2(1):214. Villablanca AC, Tetali S, Altman R, Ng KF, Rutledge JC. PMID: 23741647.
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    29. Probiotic administration in congenital heart disease: a pilot study. J Perinatol. 2013 Sep; 33(9):691-7. Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L, Schegg T, Rutledge JC, Raff G, Mills DA, Underwood MA. PMID: 23599119.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation. PLoS One. 2012; 7(11):e50513. den Hartigh LJ, Altman R, Hutchinson R, Petrlova J, Budamagunta MS, Tetali SD, Lagerstedt JO, Voss JC, Rutledge JC. PMID: 23209766.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. HIV infection and atherosclerosis: evaluating the drivers of inflammation. Eur J Prev Cardiol. 2013 Oct; 20(5):720-8. Maniar A, Ellis C, Asmuth D, Pollard R, Rutledge J. PMID: 22556374.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr. 2011 Aug 15; 57(5):363-70. Ellis CL, Ma ZM, Mann SK, Li CS, Wu J, Knight TH, Yotter T, Hayes TL, Maniar AH, Troia-Cancio PV, Overman HA, Torok NJ, Albanese A, Rutledge JC, Miller CJ, Pollard RB, Asmuth DM. PMID: 21436711.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    33. A tale of two plaques: convergent mechanisms of T-cell-mediated inflammation in psoriasis and atherosclerosis. Exp Dermatol. 2011 Jul; 20(7):544-9. Armstrong AW, Voyles SV, Armstrong EJ, Fuller EN, Rutledge JC. PMID: 21692858.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    34. Role of triglyceride-rich lipoproteins in renal injury. Contrib Nephrol. 2011; 170:165-171. Ng KF, Aung HH, Rutledge JC. PMID: 21659769.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    35. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics. 2011 Aug 16; 43(15):917-29. Aung HH, Lame MW, Gohil K, He G, Denison MS, Rutledge JC, Wilson DW. PMID: 21652769.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Angiogenesis and oxidative stress: common mechanisms linking psoriasis with atherosclerosis. J Dermatol Sci. 2011 Jul; 63(1):1-9. Armstrong AW, Voyles SV, Armstrong EJ, Fuller EN, Rutledge JC. PMID: 21600738.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    37. Lipid-cell interactions in human monocytes investigated by doubly-resonant coherent anti-Stokes Raman scattering microscopy. J Biomed Opt. 2011 Feb; 16(2):021117. Weeks T, Schie I, den Hartigh LJ, Rutledge JC, Huser T. PMID: 21361680.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. Imaging apolipoprotein AI in vivo. NMR Biomed. 2011 Aug; 24(7):916-24. Sriram R, Lagerstedt JO, Petrlova J, Samardzic H, Kreutzer U, Xie H, Kaysen GA, Desreux JF, Thonon D, Jacques V, Van Loan M, Rutledge JC, Oda MN, Voss JC, Jue T. PMID: 21264979.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Intestinal microbiota and blue baby syndrome: probiotic therapy for term neonates with cyanotic congenital heart disease. Gut Microbes. 2010 Nov-Dec; 1(6):359-66. Ellis CL, Rutledge JC, Underwood MA. PMID: 21468216.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Maternal and neonatal exposure to environmental tobacco smoke targets pro-inflammatory genes in neonatal arteries. J Cardiovasc Transl Res. 2010 Dec; 3(6):696-703. Villablanca AC, Pinkerton KE, Rutledge JC. PMID: 20890690.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsPHPublic Health
    41. Label-free imaging and analysis of the effects of lipolysis products on primary hepatocytes. J Biophotonics. 2011 Jun; 4(6):425-34. Schie IW, Wu J, Weeks T, Zern MA, Rutledge JC, Huser T. PMID: 20878906.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. The vascular contribution to Alzheimer's disease. Clin Sci (Lond). 2010 Aug 05; 119(10):407-21. Altman R, Rutledge JC. PMID: 20684749.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    43. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G440-8. de La Serre CB, Ellis CL, Lee J, Hartman AL, Rutledge JC, Raybould HE. PMID: 20508158.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    44. Role of triglyceride-rich lipoproteins in diabetic nephropathy. Nat Rev Nephrol. 2010 Jun; 6(6):361-70. Rutledge JC, Ng KF, Aung HH, Wilson DW. PMID: 20440276.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    45. Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes. J Immunol. 2010 Apr 01; 184(7):3927-36. den Hartigh LJ, Connolly-Rohrbach JE, Fore S, Huser TR, Rutledge JC. PMID: 20208007.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    46. VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation. J Lipid Res. 2010 Jun; 51(6):1273-83. Tetali SD, Budamagunta MS, Simion C, den Hartigh LJ, Kálai T, Hideg K, Hatters DM, Weisgraber KH, Voss JC, Rutledge JC. PMID: 19965582.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    47. Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. J Immunol. 2009 Nov 15; 183(10):6767-77. Barnholt KE, Kota RS, Aung HH, Rutledge JC. PMID: 19846878.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    48. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J Physiol. 2009 Dec 01; 587(Pt 23):5753-65. Sitnick M, Bodine SC, Rutledge JC. PMID: 19822547.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    49. Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo. J Cell Mol Med. 2010 Jun; 14(6B):1408-18. Ballinger ML, Osman N, Hashimura K, de Haan JB, Jandeleit-Dahm K, Allen T, Tannock LR, Rutledge JC, Little PJ. PMID: 19754668.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    50. 17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice. J Cardiovasc Transl Res. 2009 Sep; 2(3):289-99. Villablanca AC, Tenwolde A, Lee M, Huck M, Mumenthaler S, Rutledge JC. PMID: 19654889.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    51. Inflammation associated with the postprandial lipolysis of triglyceride-rich lipoproteins by lipoprotein lipase. Curr Atheroscler Rep. 2009 May; 11(3):199-205. Higgins LJ, Rutledge JC. PMID: 19361351.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    52. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation. J Lipid Res. 2009 Feb; 50(2):204-13. Wang L, Gill R, Pedersen TL, Higgins LJ, Newman JW, Rutledge JC. PMID: 18812596.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    53. Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H237-44. Wang L, Sapuri-Butti AR, Aung HH, Parikh AN, Rutledge JC. PMID: 18487440.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    54. Simultaneous forward and epi-CARS microscopy with a single detector by time-correlated single photon counting. Opt Express. 2008 Feb 04; 16(3):2168-75. Schie IW, Weeks T, McNerney GP, Fore S, Sampson JK, Wachsmann-Hogiu S, Rutledge JC, Huser T. PMID: 18542297.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    55. Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB. Vascul Pharmacol. 2008 Feb-Mar; 48(2-3):76-84. Altman R, Motton DD, Kota RS, Rutledge JC. PMID: 18255343.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    56. Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development. J Lipid Res. 2008 Mar; 49(3):521-30. Huang F, Thompson JC, Wilson PG, Aung HH, Rutledge JC, Tannock LR. PMID: 18033753.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    57. Monocyte chemoattractant protein-1 or macrophage inflammatory protein-1alpha deficiency does not affect angiotensin II-induced intimal hyperplasia in carotid artery ligation model. Cardiovasc Pathol. 2007 Jul-Aug; 16(4):231-6. Zhang LN, da Cunha V, Martin-McNulty B, Rutledge J, Vergona R, Sullivan ME, Wang YX. PMID: 17637431.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    58. Urokinase-type plasminogen activator deficiency (uPA-KO) prevented carotid artery ligation-induced vascular remodeling in mice. Transl Res. 2007 Feb; 149(2):70-5. Martin-McNulty B, Zhang L, da Cunha V, Vincelette J, Rutledge JC, Vergona R, Sullivan ME, Wang YX. PMID: 17240317.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    59. Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2745-53. Eiselein L, Wilson DW, Lamé MW, Rutledge JC. PMID: 17259442.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    60. Triglyceride-rich lipoproteins prime aortic endothelium for an enhanced inflammatory response to tumor necrosis factor-alpha. Circ Res. 2007 Feb 16; 100(3):381-90. Ting HJ, Stice JP, Schaff UY, Hui DY, Rutledge JC, Knowlton AA, Passerini AG, Simon SI. PMID: 17234968.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    61. Postprandial monocyte activation in response to meals with high and low glycemic loads in overweight women. Am J Clin Nutr. 2007 Jan; 85(1):60-5. Motton DD, Keim NL, Tenorio FA, Horn WF, Rutledge JC. PMID: 17209178.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    62. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect. 2007 Mar; 115(3):403-9. Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI. PMID: 17431490.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    63. Apolipoprotein E3- and nitric oxide-dependent modulation of endothelial cell inflammatory responses. Arterioscler Thromb Vasc Biol. 2007 Feb; 27(2):339-45. Mullick AE, Powers AF, Kota RS, Tetali SD, Eiserich JP, Rutledge JC. PMID: 17138935.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    64. Hyperglycemia and loss of ovarian hormones mediate atheroma formation through endothelial layer disruption and increased permeability. Am J Physiol Regul Integr Comp Physiol. 2007 Feb; 292(2):R723-30. Benton J, Powers A, Eiselein L, Fitch R, Wilson D, Villablanca AC, Rutledge JC. PMID: 17272672.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    65. Hyperhomocysteinemia increases arterial permeability and stiffness in mice. Am J Physiol Regul Integr Comp Physiol. 2006 Nov; 291(5):R1349-54. Mullick AE, Zaid UB, Athanassious CN, Lentz SR, Rutledge JC, Symons JD. PMID: 16793933.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    66. C-terminal interactions of apolipoprotein E4 respond to the postprandial state. J Lipid Res. 2006 Jul; 47(7):1358-65. Tetali SD, Budamagunta MS, Voss JC, Rutledge JC. PMID: 16632798.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    67. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. Int J Obes (Lond). 2006 Oct; 30(10):1545-56. Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL. PMID: 16552410.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    68. Regulation of gene expression in RAW 264.7 macrophage cell line by interferon-gamma. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1137-46. Kota RS, Rutledge JC, Gohil K, Kumar A, Enelow RI, Ramana CV. PMID: 16516165.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    69. Endothelial NO synthase deficiency promotes smooth muscle progenitor cells in association with upregulation of stromal cell-derived factor-1alpha in a mouse model of carotid artery ligation. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):765-72. Zhang LN, Wilson DW, da Cunha V, Sullivan ME, Vergona R, Rutledge JC, Wang YX. PMID: 16456092.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    70. Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):814-8. Symons JD, Zaid UB, Athanassious CN, Mullick AE, Lentz SR, Rutledge JC. PMID: 16424349.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    71. Interaction between mild hypercholesterolemia, HDL-cholesterol levels, and angiotensin II in intimal hyperplasia in mice. J Lipid Res. 2006 Mar; 47(3):476-83. da Cunha V, Martin-McNulty B, Vincelette J, Zhang L, Rutledge JC, Wilson DW, Vergona R, Sullivan ME, Wang YX. PMID: 16371646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    72. Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1190-8. Fitch RM, Rutledge JC, Wang YX, Powers AF, Tseng JL, Clary T, Rubanyi GM. PMID: 16272204.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    73. Raman spectroscopic analysis of biochemical changes in individual triglyceride-rich lipoproteins in the pre- and postprandial state. Anal Chem. 2005 Sep 15; 77(18):5870-6. Chan JW, Motton D, Rutledge JC, Keim NL, Huser T. PMID: 16159116.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    74. Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H181-91. Symons JD, Rutledge JC, Simonsen U, Pattathu RA. PMID: 16143648.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    75. Postprandial elevation of tissue factor antigen in the blood of healthy adults. Thromb Haemost. 2005 Sep; 94(3):504-9. Motton DD, Mackman N, Tilley RE, Rutledge JC. PMID: 16268463.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    76. Differential effects of lipoprotein lipase on tumor necrosis factor-alpha and interferon-gamma-mediated gene expression in human endothelial cells. J Biol Chem. 2005 Sep 02; 280(35):31076-84. Kota RS, Ramana CV, Tenorio FA, Enelow RI, Rutledge JC. PMID: 15994321.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    77. Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation. Atherosclerosis. 2005 Jan; 178(1):9-17. da Cunha V, Tham DM, Martin-McNulty B, Deng G, Ho JJ, Wilson DW, Rutledge JC, Vergona R, Sullivan ME, Wang YX. PMID: 15585195.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    78. The challenge of type 1 diabetes mellitus. ILAR J. 2004; 45(3):231-6. Eiselein L, Schwartz HJ, Rutledge JC. PMID: 15229371.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    79. Postprandial lipemia and cardiovascular disease. Curr Atheroscler Rep. 2003 Nov; 5(6):437-44. Hyson D, Rutledge JC, Berglund L. PMID: 14525676.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    80. 17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Sep 01; 23(9):1627-32. Martin-McNulty B, Tham DM, da Cunha V, Ho JJ, Wilson DW, Rutledge JC, Deng GG, Vergona R, Sullivan ME, Wang YX. PMID: 12855485.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    81. Modulation of vascular inflammation by PPARs. Drug News Perspect. 2003 Mar; 16(2):109-16. Tham DM, Wang YX, Rutledge JC. PMID: 12792672.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    82. Differential regulation of gene expression by ovariectomy in mouse aorta. Physiol Genomics. 2003 Feb 06; 12(3):175-85. Villablanca AC, Lewis KA, Tham D, Rutledge JC. PMID: 12464683.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    83. Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall. Arterioscler Thromb Vasc Biol. 2002 Dec 01; 22(12):2080-5. Mullick AE, Deckelbaum RJ, Goldberg IJ, Al-Haideri M, Rutledge JC. PMID: 12482838.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    84. Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs. Physiol Genomics. 2002 Oct 02; 11(1):21-30. Tham DM, Martin-McNulty B, Wang YX, Wilson DW, Vergona R, Sullivan ME, Dole W, Rutledge JC. PMID: 12361987.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    85. Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2002 Dec; 283(6):R1442-9. Tham DM, Martin-McNulty B, Wang YX, Da Cunha V, Wilson DW, Athanassious CN, Powers AF, Sullivan ME, Rutledge JC. PMID: 12388474.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    86. Reactive carbonyls from tobacco smoke increase arterial endothelial layer injury. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H591-7. Mullick AE, McDonald JM, Melkonian G, Talbot P, Pinkerton KE, Rutledge JC. PMID: 12124206.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    87. Apolipoprotein E mediates the retention of high-density lipoproteins by mouse carotid arteries and cultured arterial smooth muscle cell extracellular matrices. Circ Res. 2002 Jun 28; 90(12):1333-9. Olin-Lewis K, Benton JL, Rutledge JC, Baskin DG, Wight TN, Chait A. PMID: 12089072.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    88. Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function. Arterioscler Thromb Vasc Biol. 2002 May 01; 22(5):772-80. Symons JD, Mullick AE, Ensunsa JL, Ma AA, Rutledge JC. PMID: 12006389.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    89. Postprandial lipemia is associated with platelet and monocyte activation and increased monocyte cytokine expression in normolipemic men. Clin Appl Thromb Hemost. 2002 Apr; 8(2):147-55. Hyson DA, Paglieroni TG, Wun T, Rutledge JC. PMID: 12121056.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    90. Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cells. J Appl Physiol (1985). 2002 Mar; 92(3):1064-73. Villablanca AC, Lewis KA, Rutledge JC. PMID: 11842041.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    91. Links between food and vascular disease. Am J Clin Nutr. 2002 Jan; 75(1):4. Rutledge JC. PMID: 11756052.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    92. Chronic estradiol treatment attenuates stiffening, glycoxidation, and permeability in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2001 Nov; 281(5):H2204-10. Mullick AE, Walsh BA, Reiser KM, Rutledge JC. PMID: 11668084.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    93. Predictors of plasma triglyceride elevation in patients participating in a coronary atherosclerosis treatment program. J Cardiopulm Rehabil. 2001 Mar-Apr; 21(2):73-9. Parks EJ, Rutledge JC, Davis PA, Hyson DA, Schneeman BO, Kappagoda CT. PMID: 11314287.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans. Cardiovascular Health Study Collaborative Research Group. Circulation. 2000 Oct 10; 102(15):1773-9. Ariyo AA, Haan M, Tangen CM, Rutledge JC, Cushman M, Dobs A, Furberg CD. PMID: 11023931.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    95. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol. 2000 May; 35(6):1628-37. Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW, Gardin JM, Rutledge JE, Boineau RC. PMID: 10807470.
      View in: PubMed   Mentions: 247     Fields:    Translation:Humans
    96. Direct visualization of lipid deposition and reverse lipid transport in a perfused artery : roles of VLDL and HDL. Circ Res. 2000 Apr 14; 86(7):768-73. Rutledge JC, Mullick AE, Gardner G, Goldberg IJ. PMID: 10764410.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    97. Smoking and cardiovascular disease. Clin Chest Med. 2000 Mar; 21(1):159-72. Villablanca AC, McDonald JM, Rutledge JC. PMID: 10763097.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsPHPublic Health
    98. 17beta-estradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation. J Lipid Res. 2000 Jan; 41(1):134-41. Walsh BA, Mullick AE, Banka CE, Rutledge JC. PMID: 10627511.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    99. Lifestyle modification program in management of patients with coronary artery disease: the clinical experience in a tertiary care hospital. J Cardiopulm Rehabil. 1999 Jul-Aug; 19(4):226-34. Rutledge JC, Hyson DA, Garduno D, Cort DA, Paumer L, Kappagoda CT. PMID: 10453429.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    100. 17 beta-estradiol reduces glycoxidative damage in the artery wall. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):840-6. Walsh BA, Busch BL, Mullick AE, Reiser KM, Rutledge JC. PMID: 10195907.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    101. Modified LDL-mediated increases in endothelial layer permeability are attenuated with 17 beta-estradiol. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):854-61. Gardner G, Banka CL, Roberts KA, Mullick AE, Rutledge JC. PMID: 10195909.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    102. 17beta-estradiol reduces tumor necrosis factor-alpha-mediated LDL accumulation in the artery wall. J Lipid Res. 1999 Mar; 40(3):387-96. Walsh BA, Mullick AE, Walzem RL, Rutledge JC. PMID: 10064726.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    103. Reduced oxidative susceptibility of LDL from patients participating in an intensive atherosclerosis treatment program. Am J Clin Nutr. 1998 Oct; 68(4):778-85. Parks EJ, German JB, Davis PA, Frankel EN, Kappagoda CT, Rutledge JC, Hyson DA, Schneeman BO. PMID: 9771854.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    104. Regression of severe atherosclerotic plaque in patients with mild elevation of LDL cholesterol. J Investig Med. 1997 Dec; 45(9):536-41. Schaefer S, Hussein H, Gershony GR, Rutledge JC, Kappagoda CT. PMID: 9444880.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    105. Nitric oxide mediates LDL uptake in the artery wall in response to high concentrations of 17 beta-estradiol. Arterioscler Thromb Vasc Biol. 1997 Oct; 17(10):2123-31. Roberts KA, Woo MM, Rutledge JC. PMID: 9351381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    106. Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products. Circ Res. 1997 Jun; 80(6):819-28. Rutledge JC, Woo MM, Rezai AA, Curtiss LK, Goldberg IJ. PMID: 9168784.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    107. Effect of environmental tobacco smoke on LDL accumulation in the artery wall. Circulation. 1996 Nov 01; 94(9):2248-53. Roberts KA, Rezai AA, Pinkerton KE, Rutledge JC. PMID: 8901679.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsPHPublic Health
    108. Solvent drag of LDL across mammalian endothelial barriers with increased permeability. Am J Physiol. 1995 May; 268(5 Pt 2):H1982-91. Rutledge JC, Curry FE, Blanche P, Krauss RM. PMID: 7771548.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    109. Substance P increases microvascular permeability via nitric oxide-mediated convective pathways. Am J Physiol. 1995 Apr; 268(4 Pt 2):R1060-8. Nguyen LS, Villablanca AC, Rutledge JC. PMID: 7537470.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    110. Lipoprotein lipase (LpL) affects low density lipoprotein (LDL) flux through vascular tissue: evidence that LpL increases LDL accumulation in vascular tissue. J Lipid Res. 1994 Jul; 35(7):1152-60. Rutledge JC, Goldberg IJ. PMID: 7525821.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    111. Temperature and hydrostatic pressure-dependent pathways of low-density lipoprotein transport across microvascular barrier. Am J Physiol. 1992 Jan; 262(1 Pt 2):H234-45. Rutledge JC. PMID: 1733315.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    112. Extravascular distribution of low-density lipoprotein and dextran in a high-permeability state. Microvasc Res. 1990 Jul; 40(1):137-56. Rutledge JC, Pagakis SN. PMID: 1697925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    113. Low density lipoprotein transport across a microvascular endothelial barrier after permeability is increased. Circ Res. 1990 Feb; 66(2):486-95. Rutledge JC, Curry FR, Lenz JF, Davis PA. PMID: 1688742.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    114. Graded modulation of frog microvessel permeability to albumin using ionophore A23187. Am J Physiol. 1990 Feb; 258(2 Pt 2):H587-98. Curry FE, Joyner WL, Rutledge JC. PMID: 2106799.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    115. Modulation of microvessel wall charge by plasma glycoprotein orosomucoid. Am J Physiol. 1989 Nov; 257(5 Pt 2):H1354-9. Curry FE, Rutledge JC, Lenz JF. PMID: 2589490.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    116. Effect of intravenous enalaprilat in moderate and severe systemic hypertension. Am J Cardiol. 1988 Nov 15; 62(16):1062-7. Rutledge J, Ayers C, Davidson R, DiPette D, Guthrie G, Fisher M, Schwartz S, Rucinska E. PMID: 2847522.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    117. Aldosterone reverses potassium-induced food aversions in adrenalectomized rats. Physiol Behav. 1988; 42(2):137-40. Rabinowitz L, Castonguay TW, Rutledge JC. PMID: 3368531.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    118. Kaliuretic regulatory factors in the rat. Am J Physiol. 1987 Dec; 253(6 Pt 2):F1182-96. Rutledge JC, Rabinowitz L. PMID: 3425727.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    119. Malignant hypertension and asymmetric septal hypertrophy in a 43-year-old black man. West J Med. 1986 Sep; 145(3):356-61. Rutledge JC, Eng A, Silva J. PMID: 3765616.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    120. Symptomatic and silent myocardial ischemia during exercise testing in coronary artery disease. Am J Cardiol. 1986 Aug 15; 58(4):43B-46B. Amsterdam EA, Martschinske R, Laslett LJ, Rutledge JC, Vera Z. PMID: 3751902.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    121. Clinical evaluation of oral mexiletine therapy in the treatment of ventricular arrhythmias. J Am Coll Cardiol. 1985 Oct; 6(4):780-4. Rutledge JC, Harris F, Amsterdam EA. PMID: 4031292.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    122. Effects of nitroglycerin on myocardial ischemia and its clinical manifestations in severe coronary heart disease. Bibl Cardiol. 1985; (39):118-28. Amsterdam EA, Laslett L, Rutledge JC, Zakauddin V. PMID: 3939511.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    123. Differential diagnosis and clinical approach to the patient with acute chest pain. Cardiol Clin. 1984 May; 2(2):257-68. Rutledge JC, Amsterdam EA. PMID: 6399867.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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