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Jonathan R Young

Title(s)Assistant Professor, Radiology
SchoolUniversity of California, Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Coy H, Young JR, Pantuck AJ, Douek ML, Sisk A, Magyar C, Brown MS, Sayre J, Raman SS. Association of tumor grade, enhancement on multiphasic CT and microvessel density in patients with clear cell renal cell carcinoma. Abdom Radiol (NY). 2019 Oct 24. PMID: 31650375.
      View in: PubMed
    2. Banov MD, Young JR, Dunn T, Szabo ST. Efficacy and safety of ketamine in the management of anxiety and anxiety spectrum disorders: a review of the literature. CNS Spectr. 2019 Jul 24; 1-12. PMID: 31339086.
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    3. Coy H, Hsieh K, Wu W, Nagarajan MB, Young JR, Douek ML, Brown MS, Scalzo F, Raman SS. Deep learning and radiomics: the utility of Google TensorFlowâ„¢ Inception in classifying clear cell renal cell carcinoma and oncocytoma on multiphasic CT. Abdom Radiol (NY). 2019 Jun; 44(6):2009-2020. PMID: 30778739.
      View in: PubMed
    4. Coy H, Young JR, Douek ML, Pantuck A, Brown MS, Sayre J, Raman SS. Association of qualitative and quantitative imaging features on multiphasic multidetector CT with tumor grade in clear cell renal cell carcinoma. Abdom Radiol (NY). 2019 01; 44(1):180-189. PMID: 29987358.
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    5. Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS. Clear cell renal cell carcinoma: identifying PTEN expression on multiphasic MDCT. Abdom Radiol (NY). 2018 12; 43(12):3410-3417. PMID: 29946925.
      View in: PubMed
    6. Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS. Association of the Gross Appearance of Intratumoral Vascularity at MDCT With the Carbonic Anhydrase IX Score in Clear Cell Renal Cell Carcinoma. AJR Am J Roentgenol. 2018 12; 211(6):1254-1258. PMID: 30300009.
      View in: PubMed
    7. Young JR, Coy H, Kim HJ, Douek M, Sisk A, Belldegrun A, Pantuck AJ, Raman SS. Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression. Abdom Radiol (NY). 2018 10; 43(10):2734-2742. PMID: 29520426.
      View in: PubMed
    8. Young JR, Pope WB, Bobinski M. Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol. AJNR Am J Neuroradiol. 2018 09; 39(9):1604-1608. PMID: 30093477.
      View in: PubMed
    9. Young JR, Qiao J, Orosz I, Salamon N, Franke MA, Kim HJ, Pope WB. Gadolinium deposition within the paediatric brain: no increased intrinsic T1-weighted signal intensity within the dentate nucleus following the administration of a minimum of four doses of the macrocyclic agent gadobutrol. Eur Radiol. 2018 Nov; 28(11):4882-4889. PMID: 29744642.
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    10. Young JR, Orosz I, Franke MA, Kim HJ, Woodworth D, Ellingson BM, Salamon N, Pope WB. Gadolinium deposition in the paediatric brain: T1-weighted hyperintensity within the dentate nucleus following repeated gadolinium-based contrast agent administration. Clin Radiol. 2018 03; 73(3):290-295. PMID: 29208312.
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    11. Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, Mampreian DM, Shi F, Liu D, Fradera X, Johnson K, Bays N, Kadic E, He F, Goldenblatt P, Shaffer L, Patel SB, Lesburg CA, Alpert C, Dorosh L, Deshmukh SV, Yu H, Klappenbach J, Elwood F, Dinsmore CJ, Fernandez R, Moy L, Young JR. The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 12 14; 60(23):9676-9690. PMID: 29156136.
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    12. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Type 1 papillary renal cell carcinoma: differentiation from Type 2 papillary RCC on multiphasic MDCT. Abdom Radiol (NY). 2017 07; 42(7):1911-1918. PMID: 28265706.
      View in: PubMed
    13. Coy H, Young JR, Douek ML, Brown MS, Sayre J, Raman SS. Quantitative computer-aided diagnostic algorithm for automated detection of peak lesion attenuation in differentiating clear cell from papillary and chromophobe renal cell carcinoma, oncocytoma, and fat-poor angiomyolipoma on multiphasic multidetector computed tomography. Abdom Radiol (NY). 2017 07; 42(7):1919-1928. PMID: 28280876.
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    14. Young JR, Young JA, Margolis DJA, Sauk S, Sayre J, Pantuck AJ, Raman SS. Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. Acad Radiol. 2017 10; 24(10):1226-1232. PMID: 28528853.
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    15. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying the Loss of the Y Chromosome on Multiphasic MDCT. AJR Am J Roentgenol. 2017 Aug; 209(2):333-338. PMID: 28504543.
      View in: PubMed
    16. Young JR, Coy H, Kim HJ, Douek M, Lo P, Pantuck AJ, Raman SS. Performance of Relative Enhancement on Multiphasic MRI for the Differentiation of Clear Cell Renal Cell Carcinoma (RCC) From Papillary and Chromophobe RCC Subtypes and Oncocytoma. AJR Am J Roentgenol. 2017 Apr; 208(4):812-819. PMID: 28125273.
      View in: PubMed
    17. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear cell renal cell carcinoma: identifying the gain of chromosome 12 on multiphasic MDCT. Abdom Radiol (NY). 2017 01; 42(1):236-241. PMID: 27519835.
      View in: PubMed
    18. Young JR, Young JA, Margolis DJ, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT. Abdom Radiol (NY). 2016 11; 41(11):2175-2181. PMID: 27315079.
      View in: PubMed
    19. Simov V, Deshmukh SV, Dinsmore CJ, Elwood F, Fernandez RB, Garcia Y, Gibeau C, Gunaydin H, Jung J, Katz JD, Kraybill B, Lapointe B, Patel SB, Siu T, Su H, Young JR. Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1803-8. PMID: 26927423.
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    20. Lee-Felker SA, Felker ER, Tan N, Margolis DJ, Young JR, Sayre J, Raman SS. Qualitative and quantitative MDCT features for differentiating clear cell renal cell carcinoma from other solid renal cortical masses. AJR Am J Roentgenol. 2014 Nov; 203(5):W516-24. PMID: 25341166.
      View in: PubMed
    21. Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Young JA, Hsu M, Raman SS. Clear cell renal cell carcinoma: multiphasic MDCT enhancement can predict the loss of chromosome 8p. Abdom Imaging. 2014 Jun; 39(3):543-9. PMID: 24573763.
      View in: PubMed
    22. Haidle AM, Zabierek AA, Childers KK, Rosenstein C, Mathur A, Altman MD, Chan G, Xu L, Bachman E, Mo JR, Bouthillette M, Rush T, Tempest P, Marshall CG, Young JR. Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms. Bioorg Med Chem Lett. 2014 Apr 15; 24(8):1968-73. PMID: 24666646.
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    23. Siu T, Kumarasinghe SE, Altman MD, Katcher M, Northrup A, White C, Rosenstein C, Mathur A, Xu L, Chan G, Bachman E, Bouthillette M, Dinsmore CJ, Marshall CG, Young JR. The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization. Bioorg Med Chem Lett. 2014 Mar 15; 24(6):1466-71. PMID: 24582987.
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    24. Northrup AB, Katcher MH, Altman MD, Chenard M, Daniels MH, Deshmukh SV, Falcone D, Guerin DJ, Hatch H, Li C, Lu W, Lutterbach B, Allison TJ, Patel SB, Reilly JF, Reutershan M, Rickert KW, Rosenstein C, Soisson SM, Szewczak AA, Walker D, Wilson K, Young JR, Pan BS, Dinsmore CJ. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. J Med Chem. 2013 Mar 28; 56(6):2294-310. PMID: 23379595.
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    25. Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology. 2013 May; 267(2):444-53. PMID: 23382290.
      View in: PubMed
    26. Kraus M, Wang Y, Aleksandrowicz D, Bachman E, Szewczak AA, Walker D, Xu L, Bouthillette M, Childers KM, Dolinski B, Haidle AM, Kopinja J, Lee L, Lim J, Little KD, Ma Y, Mathur A, Mo JR, O'Hare E, Otte RD, Taoka BM, Wang W, Yin H, Zabierek AA, Zhang W, Zhao S, Zhu J, Young JR, Marshall CG. Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera. PLoS One. 2012; 7(5):e37207. PMID: 22623993.
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    27. McGill ML, Devinsky O, Kelly C, Milham M, Castellanos FX, Quinn BT, DuBois J, Young JR, Carlson C, French J, Kuzniecky R, Halgren E, Thesen T. Default mode network abnormalities in idiopathic generalized epilepsy. Epilepsy Behav. 2012 Mar; 23(3):353-9. PMID: 22381387.
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    28. Lim J, Taoka B, Otte RD, Spencer K, Dinsmore CJ, Altman MD, Chan G, Rosenstein C, Sharma S, Su HP, Szewczak AA, Xu L, Yin H, Zugay-Murphy J, Marshall CG, Young JR. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem. 2011 Oct 27; 54(20):7334-49. PMID: 21942426.
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    29. Pope WB, Young JR, Ellingson BM. Advances in MRI assessment of gliomas and response to anti-VEGF therapy. Curr Neurol Neurosci Rep. 2011 Jun; 11(3):336-44. PMID: 21234719.
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    30. Pope WB, Lai A, Mehta R, Kim HJ, Qiao J, Young JR, Xue X, Goldin J, Brown MS, Nghiemphu PL, Tran A, Cloughesy TF. Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. AJNR Am J Neuroradiol. 2011 May; 32(5):882-9. PMID: 21330401.
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    31. Siu T, Kozina ES, Jung J, Rosenstein C, Mathur A, Altman MD, Chan G, Xu L, Bachman E, Mo JR, Bouthillette M, Rush T, Dinsmore CJ, Marshall CG, Young JR. The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7421-5. PMID: 21044843.
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    32. Ma Y, Zhao S, Zhu J, Bettano KA, Qu X, Marshall CG, Young JR, Kohl NE, Scott ML, Zhang W, Wang Y. Real-time bioluminescence imaging of polycythemia vera development in mice. Biochim Biophys Acta. 2009 Nov; 1792(11):1073-9. PMID: 19715759.
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    33. Pope WB, Kim HJ, Huo J, Alger J, Brown MS, Gjertson D, Sai V, Young JR, Tekchandani L, Cloughesy T, Mischel PS, Lai A, Nghiemphu P, Rahmanuddin S, Goldin J. Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009 Jul; 252(1):182-9. PMID: 19561256.
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    34. Morriello GJ, Devita RJ, Mills SG, Young JR, Lin P, Doss G, Chicchi GG, Demartino J, Kurtz MM, Tsao KL, Carlson E, Townson K, Wheeldon A, Boyce S, Collinson N, Rupniak N, Moore S. Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists. Bioorg Med Chem. 2008 Mar 01; 16(5):2156-70. PMID: 18248994.
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    35. Young JR, Eid R, Turner C, DeVita RJ, Kurtz MM, Tsao KL, Chicchi GG, Wheeldon A, Carlson E, Mills SG. Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists. Bioorg Med Chem Lett. 2007 Oct 01; 17(19):5310-5. PMID: 17723300.
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    36. Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, Burns HD, Hargreaves RJ, Mills SG. The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5191-8. PMID: 17637506.
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    37. Jiang J, Hoang M, Young JR, Chaung D, Eid R, Turner C, Lin P, Tong X, Wang J, Tan C, Feighner S, Palyha O, Hreniuk DL, Pan J, Sailer AW, MacNeil DJ, Howard A, Shearman L, Stribling S, Camacho R, Strack A, Van der Ploeg LH, Goulet MT, DeVita RJ. 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorg Med Chem Lett. 2006 Oct 15; 16(20):5270-4. PMID: 16919456.
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    38. DeVita RJ, Parikh M, Jiang J, Fair JA, Young JR, Walsh TF, Goulet MT, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP, Wyvratt MJ. Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 15; 14(22):5599-603. PMID: 15482932.
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    39. Young JR, Huang SX, Walsh TF, Wyvratt MJ, Yang YT, Yudkovitz JB, Cui J, Mount GR, Ren RN, Wu TJ, Shen X, Lyons KA, Mao AH, Carlin JR, Karanam BV, Vincent SH, Cheng K, Goulet MT. 2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain. Bioorg Med Chem Lett. 2002 Mar 11; 12(5):827-32. PMID: 11859012.
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