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Jonathan R Young

TitleASST PROF OF CLIN-HCOMP
InstitutionUniversity of California Davis
DepartmentRadiology
Address4860 Y St
CA 95817
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Young JR, Pope WB, Bobinski M. Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol. AJNR Am J Neuroradiol. 2018 Aug 09. PMID: 30093477.
      View in: PubMed
    2. Coy H, Young JR, Douek ML, Pantuck A, Brown MS, Sayre J, Raman SS. Association of qualitative and quantitative imaging features on multiphasic multidetector CT with tumor grade in clear cell renal cell carcinoma. Abdom Radiol (NY). 2018 Jul 09. PMID: 29987358.
      View in: PubMed
    3. Young JR, Coy H, Kim HJ, Douek M, Sisk A, Pantuck AJ, Raman SS. Clear cell renal cell carcinoma: identifying PTEN expression on multiphasic MDCT. Abdom Radiol (NY). 2018 Jun 27. PMID: 29946925.
      View in: PubMed
    4. Young JR, Qiao J, Orosz I, Salamon N, Franke MA, Kim HJ, Pope WB. Gadolinium deposition within the paediatric brain: no increased intrinsic T1-weighted signal intensity within the dentate nucleus following the administration of a minimum of four doses of the macrocyclic agent gadobutrol. Eur Radiol. 2018 May 09. PMID: 29744642.
      View in: PubMed
    5. Young JR, Coy H, Kim HJ, Douek M, Sisk A, Belldegrun A, Pantuck AJ, Raman SS. Utility of multiphasic multidetector computed tomography in discriminating between clear cell renal cell carcinomas with high and low carbonic anhydrase-IX expression. Abdom Radiol (NY). 2018 Mar 08. PMID: 29520426.
      View in: PubMed
    6. Siu T, Brubaker J, Fuller P, Torres L, Zeng H, Close J, Mampreian DM, Shi F, Liu D, Fradera X, Johnson K, Bays N, Kadic E, He F, Goldenblatt P, Shaffer L, Patel SB, Lesburg CA, Alpert C, Dorosh L, Deshmukh SV, Yu H, Klappenbach J, Elwood F, Dinsmore CJ, Fernandez R, Moy L, Young JR. The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14; 60(23):9676-9690. PMID: 29156136.
      View in: PubMed
    7. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Type 1 papillary renal cell carcinoma: differentiation from Type 2 papillary RCC on multiphasic MDCT. Abdom Radiol (NY). 2017 Jul; 42(7):1911-1918. PMID: 28265706.
      View in: PubMed
    8. Coy H, Young JR, Douek ML, Brown MS, Sayre J, Raman SS. Quantitative computer-aided diagnostic algorithm for automated detection of peak lesion attenuation in differentiating clear cell from papillary and chromophobe renal cell carcinoma, oncocytoma, and fat-poor angiomyolipoma on multiphasic multidetector computed tomography. Abdom Radiol (NY). 2017 Jul; 42(7):1919-1928. PMID: 28280876.
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    9. Young JR, Young JA, Margolis DJA, Sauk S, Sayre J, Pantuck AJ, Raman SS. Sarcomatoid Renal Cell Carcinoma and Collecting Duct Carcinoma: Discrimination From Common Renal Cell Carcinoma Subtypes and Benign RCC Mimics on Multiphasic MDCT. Acad Radiol. 2017 Oct; 24(10):1226-1232. PMID: 28528853.
      View in: PubMed
    10. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear Cell Renal Cell Carcinoma: Identifying the Loss of the Y Chromosome on Multiphasic MDCT. AJR Am J Roentgenol. 2017 Aug; 209(2):333-338. PMID: 28504543.
      View in: PubMed
    11. Young JR, Coy H, Kim HJ, Douek M, Lo P, Pantuck AJ, Raman SS. Performance of Relative Enhancement on Multiphasic MRI for the Differentiation of Clear Cell Renal Cell Carcinoma (RCC) From Papillary and Chromophobe RCC Subtypes and Oncocytoma. AJR Am J Roentgenol. 2017 Apr; 208(4):812-819. PMID: 28125273.
      View in: PubMed
    12. Young JR, Coy H, Douek M, Lo P, Sayre J, Pantuck AJ, Raman SS. Clear cell renal cell carcinoma: identifying the gain of chromosome 12 on multiphasic MDCT. Abdom Radiol (NY). 2017 Jan; 42(1):236-241. PMID: 27519835.
      View in: PubMed
    13. Young JR, Young JA, Margolis DJ, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear cell renal cell carcinoma: identifying the gain of chromosome 20 on multiphasic MDCT. Abdom Radiol (NY). 2016 Nov; 41(11):2175-2181. PMID: 27315079.
      View in: PubMed
    14. Simov V, Deshmukh SV, Dinsmore CJ, Elwood F, Fernandez RB, Garcia Y, Gibeau C, Gunaydin H, Jung J, Katz JD, Kraybill B, Lapointe B, Patel SB, Siu T, Su H, Young JR. Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1803-8. PMID: 26927423.
      View in: PubMed
    15. Lee-Felker SA, Felker ER, Tan N, Margolis DJ, Young JR, Sayre J, Raman SS. Qualitative and quantitative MDCT features for differentiating clear cell renal cell carcinoma from other solid renal cortical masses. AJR Am J Roentgenol. 2014 Nov; 203(5):W516-24. PMID: 25341166.
      View in: PubMed
    16. Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Young JA, Hsu M, Raman SS. Clear cell renal cell carcinoma: multiphasic MDCT enhancement can predict the loss of chromosome 8p. Abdom Imaging. 2014 Jun; 39(3):543-9. PMID: 24573763.
      View in: PubMed
    17. Haidle AM, Zabierek AA, Childers KK, Rosenstein C, Mathur A, Altman MD, Chan G, Xu L, Bachman E, Mo JR, Bouthillette M, Rush T, Tempest P, Marshall CG, Young JR. Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms. Bioorg Med Chem Lett. 2014 Apr 15; 24(8):1968-73. PMID: 24666646.
      View in: PubMed
    18. Siu T, Kumarasinghe SE, Altman MD, Katcher M, Northrup A, White C, Rosenstein C, Mathur A, Xu L, Chan G, Bachman E, Bouthillette M, Dinsmore CJ, Marshall CG, Young JR. The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization. Bioorg Med Chem Lett. 2014 Mar 15; 24(6):1466-71. PMID: 24582987.
      View in: PubMed
    19. Northrup AB, Katcher MH, Altman MD, Chenard M, Daniels MH, Deshmukh SV, Falcone D, Guerin DJ, Hatch H, Li C, Lu W, Lutterbach B, Allison TJ, Patel SB, Reilly JF, Reutershan M, Rickert KW, Rosenstein C, Soisson SM, Szewczak AA, Walker D, Wilson K, Young JR, Pan BS, Dinsmore CJ. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. J Med Chem. 2013 Mar 28; 56(6):2294-310. PMID: 23379595.
      View in: PubMed
    20. Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS. Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology. 2013 May; 267(2):444-53. PMID: 23382290.
      View in: PubMed
    21. Kraus M, Wang Y, Aleksandrowicz D, Bachman E, Szewczak AA, Walker D, Xu L, Bouthillette M, Childers KM, Dolinski B, Haidle AM, Kopinja J, Lee L, Lim J, Little KD, Ma Y, Mathur A, Mo JR, O'Hare E, Otte RD, Taoka BM, Wang W, Yin H, Zabierek AA, Zhang W, Zhao S, Zhu J, Young JR, Marshall CG. Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera. PLoS One. 2012; 7(5):e37207. PMID: 22623993; PMCID: PMC3356383.
    22. McGill ML, Devinsky O, Kelly C, Milham M, Castellanos FX, Quinn BT, DuBois J, Young JR, Carlson C, French J, Kuzniecky R, Halgren E, Thesen T. Default mode network abnormalities in idiopathic generalized epilepsy. Epilepsy Behav. 2012 Mar; 23(3):353-9. PMID: 22381387; PMCID: PMC4407647.
    23. Lim J, Taoka B, Otte RD, Spencer K, Dinsmore CJ, Altman MD, Chan G, Rosenstein C, Sharma S, Su HP, Szewczak AA, Xu L, Yin H, Zugay-Murphy J, Marshall CG, Young JR. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem. 2011 Oct 27; 54(20):7334-49. PMID: 21942426.
      View in: PubMed
    24. Pope WB, Young JR, Ellingson BM. Advances in MRI assessment of gliomas and response to anti-VEGF therapy. Curr Neurol Neurosci Rep. 2011 Jun; 11(3):336-44. PMID: 21234719; PMCID: PMC3075404.
    25. Siu T, Kozina ES, Jung J, Rosenstein C, Mathur A, Altman MD, Chan G, Xu L, Bachman E, Mo JR, Bouthillette M, Rush T, Dinsmore CJ, Marshall CG, Young JR. The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7421-5. PMID: 21044843.
      View in: PubMed
    26. Ma Y, Zhao S, Zhu J, Bettano KA, Qu X, Marshall CG, Young JR, Kohl NE, Scott ML, Zhang W, Wang Y. Real-time bioluminescence imaging of polycythemia vera development in mice. Biochim Biophys Acta. 2009 Nov; 1792(11):1073-9. PMID: 19715759.
      View in: PubMed
    27. Pope WB, Kim HJ, Huo J, Alger J, Brown MS, Gjertson D, Sai V, Young JR, Tekchandani L, Cloughesy T, Mischel PS, Lai A, Nghiemphu P, Rahmanuddin S, Goldin J. Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009 Jul; 252(1):182-9. PMID: 19561256.
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    28. Morriello GJ, Devita RJ, Mills SG, Young JR, Lin P, Doss G, Chicchi GG, Demartino J, Kurtz MM, Tsao KL, Carlson E, Townson K, Wheeldon A, Boyce S, Collinson N, Rupniak N, Moore S. Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists. Bioorg Med Chem. 2008 Mar 01; 16(5):2156-70. PMID: 18248994.
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    29. Young JR, Eid R, Turner C, DeVita RJ, Kurtz MM, Tsao KL, Chicchi GG, Wheeldon A, Carlson E, Mills SG. Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists. Bioorg Med Chem Lett. 2007 Oct 01; 17(19):5310-5. PMID: 17723300.
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    30. Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, Burns HD, Hargreaves RJ, Mills SG. The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5191-8. PMID: 17637506.
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    31. Jiang J, Hoang M, Young JR, Chaung D, Eid R, Turner C, Lin P, Tong X, Wang J, Tan C, Feighner S, Palyha O, Hreniuk DL, Pan J, Sailer AW, MacNeil DJ, Howard A, Shearman L, Stribling S, Camacho R, Strack A, Van der Ploeg LH, Goulet MT, DeVita RJ. 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorg Med Chem Lett. 2006 Oct 15; 16(20):5270-4. PMID: 16919456.
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    32. DeVita RJ, Parikh M, Jiang J, Fair JA, Young JR, Walsh TF, Goulet MT, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP, Wyvratt MJ. Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 15; 14(22):5599-603. PMID: 15482932.
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    33. Young JR, Huang SX, Walsh TF, Wyvratt MJ, Yang YT, Yudkovitz JB, Cui J, Mount GR, Ren RN, Wu TJ, Shen X, Lyons KA, Mao AH, Carlin JR, Karanam BV, Vincent SH, Cheng K, Goulet MT. 2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain. Bioorg Med Chem Lett. 2002 Mar 11; 12(5):827-32. PMID: 11859012.
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