Julian Halmai

Title(s)Assistant Professor in Residence, Med: Neurology
SchoolSchool of Medicine
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    1. Durable HTT silencing using non-evolved dCas9 epigenome editors in patient-derived cells. Mol Ther Nucleic Acids. 2025 Jun 10; 36(2):102561. Waldo JJ, Halmai JANM, Singh A, Gonzalez CE, Chen YA, Carthen SA, Nolta JA, Fink KD. PMID: 40520366; PMCID: PMC12163160.
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    2. A de novo missense mutation in PPP2R5D alters dopamine pathways and morphology of iPSC-derived midbrain neurons. Stem Cells. 2025 Jan 17; 43(1). Carter JL, Halmai JANM, Waldo JJ, Vij PA, Anguiano M, Villegas IJ, Du YX, Nolta J, Fink KD. PMID: 39460716; PMCID: PMC11811633.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Epigenetic editing for autosomal dominant neurological disorders. Front Genome Ed. 2024; 6:1304110. Waldo JJ, Halmai JANM, Fink KD. PMID: 38510848; PMCID: PMC10950933.
      View in: PubMed   Mentions: 3  
    4. Role of MEF2C in the Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Stem Cells. 2023 04 25; 41(4):341-353. Li T, Conroy KL, Kim AM, Halmai J, Gao K, Moreno E, Wang A, Passerini AG, Nolta JA, Zhou P. PMID: 36639926; PMCID: PMC10128960.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model. Mol Ther. 2023 04 05; 31(4):1088-1105. O'Geen H, Beitnere U, Garcia MS, Adhikari A, Cameron DL, Fenton TA, Copping NA, Deng P, Lock S, Halmai JANM, Villegas IJ, Liu J, Wang D, Fink KD, Silverman JL, Segal DJ. PMID: 36641623; PMCID: PMC10124086.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    6. Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency. Hum Mol Genet. 2022 09 10; 31(18):3032-3050. Adhikari A, Buchanan FKB, Fenton TA, Cameron DL, Halmai JANM, Copping NA, Fink KD, Silverman JL. PMID: 35445702; PMCID: PMC9476626.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    7. Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids. Diagnostics (Basel). 2022 Mar 24; 12(4). DeFelice BC, Fiehn O, Belafsky P, Ditterich C, Moore M, Abouyared M, Beliveau AM, Farwell DG, Bewley AF, Clayton SM, Archard JA, Pavlic J, Rao S, Kuhn M, Deng P, Halmai J, Fink KD, Birkeland AC, Anderson JD. PMID: 35453845; PMCID: PMC9024570.
      View in: PubMed   Mentions: 8  
    8. An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models. Front Mol Neurosci. 2021; 14:789913. Deng P, Halmai JANM, Beitnere U, Cameron D, Martinez ML, Lee CC, Waldo JJ, Thongphanh K, Adhikari A, Copping N, Petkova SP, Lee RD, Lock S, Palomares M, O'Geen H, Carter J, Gonzalez CE, Buchanan FKB, Anderson JD, Fierro FA, Nolta JA, Tarantal AF, Silverman JL, Segal DJ, Fink KD. PMID: 35153670; PMCID: PMC8829036.
      View in: PubMed   Mentions: 3  
    9. Cell-Based Delivery Approaches for DNA-Binding Domains to the Central Nervous System. Curr Neuropharmacol. 2021; 19(12):2125-2140. Deng P, Halmai J, Waldo JJ, Fink KD. PMID: 33998992; PMCID: PMC9185769.
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    10. The iNs and Outs of Direct Reprogramming to Induced Neurons. Front Genome Ed. 2020; 2:7. Carter JL, Halmai JANM, Fink KD. PMID: 34713216; PMCID: PMC8525349.
      View in: PubMed   Mentions: 12  
    11. Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Nucleic Acids Res. 2020 03 18; 48(5):2372-2387. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. PMID: 31925439; PMCID: PMC7049732.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    12. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019 May 03; 12(1):26. O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. PMID: 31053162; PMCID: PMC6498470.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    13. Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation. Biochem Biophys Res Commun. 2019 05 14; 512(4):729-735. Showalter MR, Wancewicz B, Fiehn O, Archard JA, Clayton S, Wagner J, Deng P, Halmai J, Fink KD, Bauer G, Fury B, Perotti NH, Apperson M, Butters J, Belafsky P, Farwell G, Kuhn M, Nolta JA, Anderson JD. PMID: 30926165; PMCID: PMC6682414.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    14. Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion. Stem Cells Dev. 2019 03 15; 28(6):398-409. Yuan O, Lin C, Wagner J, Archard JA, Deng P, Halmai J, Bauer G, Fink KD, Fury B, Perotti NH, Walker JE, Pollock K, Apperson M, Butters J, Belafsky P, Farwell DG, Kuhn M, Nolta J, Anderson JD. PMID: 30638129; PMCID: PMC6441283.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    15. Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy. Sci Rep. 2018 07 27; 8(1):11348. Napoli E, Song G, Panoutsopoulos A, Riyadh MA, Kaushik G, Halmai J, Levenson R, Zarbalis KS, Giulivi C. PMID: 30054502; PMCID: PMC6063930.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    16. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Res. 2017 Sep 29; 45(17):9901-9916. O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ. PMID: 28973434; PMCID: PMC5622328.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    17. Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation. Biochem J. 2016 11 01; 473(21):3871-3888. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. PMID: 27555610; PMCID: PMC7014977.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    18. Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. Front Mol Neurosci. 2016; 9:71. Giulivi C, Napoli E, Tassone F, Halmai J, Hagerman R. PMID: 27570505; PMCID: PMC4981605.
      View in: PubMed   Mentions: 20  
    19. [Not Available]. Orvostort Kozl. 1974; 71-72:137-50. Halmai J. PMID: 11627424.
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    20. [Not Available]. Veroff Int Ges Gesch Pharm. 1972; 38:129-34. Halmai J. PMID: 11609480.
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    21. Common thyme (Thymus vulgaris) as employed for the ancient methods of embalming. Ther Hung. 1972; 20(4):162-5. Halmai J. PMID: 4601333.
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    22. [Not Available]. Orvostort Kozl. 1971; 57-59:303-10. Halmai J. PMID: 11626257.
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    23. [Daniel Wágner and his reform plants]. Orv Hetil. 1970 Dec 27; 111(52):3089-91. Halmai J. PMID: 4924847.
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    24. [Friedrich Wöhler, destroyer of the "vis vital" myth]. Orv Hetil. 1970 Dec 27; 111(52):3091-3. Halmai J. PMID: 4924848.
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    25. [Antal Fauser, minerologist, pharmacist]. Orv Hetil. 1970 Dec 13; 111(50):2970-1. Halmai J. PMID: 4923880.
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    26. [Not Available]. Veroff Int Ges Gesch Pharm. 1970; 36:73-8. Halmai J. PMID: 11626293.
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    27. [Not Available]. Orvostort Kozl. 1970; Suppl 4:111-22. Halmai J. PMID: 11626226.
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    28. [ndre Deér, founder of the Hungarian Pharmacological Society]. Orv Hetil. 1969 Jun 29; 110(26):1511-2. Halmai J. PMID: 4893480.
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    29. [Dr. Miklos Matolcsy, founder of the pharmacy of the Budapest University Medical School]. Orv Hetil. 1969 Jun 01; 110(22):1277-8. Halmai J. PMID: 4893784.
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    30. [Not Available]. Burgenl Heimatbl. 1969; 31(4):181-7. Halmai J. PMID: 11631738.
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    31. [Endre Deér and the Hungarian Society of Pharmacists]. Acta Pharm Hung. 1969 Jan; 39(1):1-9. Halmai J. PMID: 4887759.
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    32. [In commemoration of Pál Kitaibel]. Orv Hetil. 1968 May 19; 109(20):1097-100. Halmai J. PMID: 4882313.
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    33. [The physicist of Nagy-Kun. (Gábor Kátai)]. Orv Hetil. 1968 Mar 24; 109(12):649-51. Halmai J. PMID: 4881385.
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    34. [J. B. Caventou]. Orv Hetil. 1968 Feb 11; 109(6):319-21. Halmai J. PMID: 4879397.
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    35. [Zamenhof and the esperanto language]. Orv Hetil. 1967 Jul 30; 108(31):1473-7. Halmai J. PMID: 4864977.
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    36. [Piotr Wierzbicki--physician and botanist]. Orv Hetil. 1967 Jul 02; 108(27):1281-4. Halmai J. PMID: 4864767.
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    37. [The Hungarian Scheele. (Endre Kazay)]. Orv Hetil. 1967 Feb 12; 108(7):318-80. Halmai J. PMID: 4859771.
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    38. [On the change in part of the day of the solasodin content of the medicinal nightshade (Solanum laciniatum Ait.)]. Acta Pharm Hung. 1967 Jan; 37(1):30-4. Váradi J, Csapó E, Halmai J. PMID: 6063067.
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    39. [The pharmacist from Köping (Carl Wilhelm Scheele)]. Orv Hetil. 1966 Nov 20; 107(47):2240-3. Halmai J. PMID: 5342119.
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    40. [The inventor of morphine. (F. W. Sertürner)]. Orv Hetil. 1966 May 08; 107(19):895-7. Halmai J. PMID: 5326676.
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    41. [ERNST ABBE, A SOCIAL REFORMER]. Orv Hetil. 1965 Mar 07; 106:463-6. HALMAI J. PMID: 14335936.
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    42. [CASPAR BAUHIN]. Orv Hetil. 1965 Feb 07; 106:276-7. HALMAI J. PMID: 14256510.
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    43. [ANDRAS BEYTHE, AUTHOR OF THE "FIVES KOENUEV" (HERBAL)]. Orv Hetil. 1964 Nov 15; 105:2197-8. HALMAI J. PMID: 14218026.
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    44. [PROFESSOR OF CHEMISTRY AND BOTANY OF THE UNIVERSITY OF NAGYSZOMBAT (J'OSEF JAKAB WINTERL)]. Orv Hetil. 1964 Aug 23; 105:1613-5. WINTERL JJ, HALMAI J. PMID: 14177218.
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    45. [PROFESSOR OF CHEMISTRY AND BOTANY OF THE UNIVERSITY OF NAGYSZOMBAT (J'OSEF JAKAB WINTERL)]. Orv Hetil. 1964 Aug 23; 105:1613-5. HALMAI J. PMID: 14179886.
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    46. [THE USE OF MEDICINAL PLANTS IN THE HUNGARIAN PEOPLE'S REPUBLIC]. Pharm Prax. 1964; 19:57-9. HALMAI J. PMID: 14245710.
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    47. [17TH REPORT ON THE REGULAR MEETING OF THE ZENTRALE GUTACHTERAUSSCHUSS FUER ARZNEIMITTELVERKEHR ON 19 SEPTEMBER 1963]. Pharm Prax. 1964; 19:59-64. HALMAI J. PMID: 14245711.
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    48. [ANTONY LEEUWENHOEK]. Orv Hetil. 1963 Oct 06; 104:1906-7. HALMAI J. PMID: 14153626.
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    49. [Justus LIEBIG]. Orv Hetil. 1963 Aug 11; 104:1523-4. HALMAI J. PMID: 13952197.
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    50. [Samuel DIOSZEGI]. Orv Hetil. 1963 Jul 28; 104:1425-6. HALMAI J. PMID: 13952196.
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    51. [Lajos WINKLER]. Orv Hetil. 1963 Jun 30; 104:1235-6. HALMAI J. PMID: 13952198.
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    52. [Endre KAZAY]. Orv Hetil. 1963 May 05; 104:846-7. HALMAI J. PMID: 13952201.
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    53. [Carl Wihelm SCHEELE]. Orv Hetil. 1963 Jan 27; 104:170-1. HALMAI J. PMID: 13952200.
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    54. [Peter MELIUSZ JUHASZ]. Orv Hetil. 1963 Jan 13; 104:77-8. HALMAI J. PMID: 13952199.
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    55. [Not Available]. Gyogyszeresz. 1955 Feb 01; 10(2):36. HALMAI J. PMID: 24543576.
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    56. [40 Years of the Pharmaceutic Institute]. Gyogyszeresz. 1955 Jan 01; 10(1):14-5. HALMAI J. PMID: 24543569.
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    57. [Production of medicinal herbs]. Gyogyszeresz. 1954 Jun 01; 9(6):113-4. HALMAI J. PMID: 24543151.
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    58. Tiliae flos. Gyogyszeresz. 1953 Oct 01; 8(10):174-5. HALMAI J. PMID: 24542975.
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    59. [New medicinal plant extracts in the Soviet Union]. Gyogyszeresz. 1953 May 01; 8(5):86-7. HALMAI J. PMID: 24542664.
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    60. [The rose hip]. Gyogyszeresz. 1953 Apr 01; 8(4):80. HALMAI J. PMID: 24542518.
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    61. [Uniform writing in pharmacology and pharmacopeia]. Gyogyszeresz. 1951 Dec; 6(12):271-2. HALMAI J. PMID: 24542305.
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