Kazuharu Furutani

Title(s)Assistant Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Address1275 Med Sci Drive
CA 95616
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 2022; 13:966463. Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 36188564; PMCID: PMC9523588.
      View in: PubMed   Mentions: 1  
    2. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Mol Pharmacol. 2022 Aug 30. Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. PMID: 36041862; PMCID: PMC9595204.
      View in: PubMed   Mentions: 1     Fields:    
    3. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes. J Pharmacol Sci. 2019 Aug; 140(4):325-330. Kodama M, Furutani K, Kimura R, Ando T, Sakamoto K, Nagamori S, Ashihara T, Kurachi Y, Sekino Y, Furukawa T, Kanda Y, Kurokawa J. PMID: 31279582.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Integrative and theoretical research on the architecture of a biological system and its disorder. J Physiol Sci. 2019 May; 69(3):433-451. Uchida S, Asai Y, Kariya Y, Tsumoto K, Hibino H, Honma M, Abe T, Nin F, Kurata Y, Furutani K, Suzuki H, Kitano H, Inoue R, Kurachi Y. PMID: 30868372; PMCID: PMC6456489.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations. J Gen Physiol. 2019 02 04; 151(2):214-230. Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. PMID: 30674563; PMCID: PMC6363420.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption. J Physiol. 2018 03 01; 596(5):743-746. Funato Y, Furutani K, Kurachi Y, Miki H. PMID: 29383719; PMCID: PMC5830418.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    8. Rebuttal from Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi and Hiroaki Miki. J Physiol. 2018 03 01; 596(5):751. Funato Y, Furutani K, Kurachi Y, Miki H. PMID: 29383723; PMCID: PMC5830423.
      View in: PubMed   Mentions: 6     Fields:    
    9. Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias. Sci Rep. 2017 09 07; 7(1):10771. Tsumoto K, Kurata Y, Furutani K, Kurachi Y. PMID: 28883639; PMCID: PMC5589958.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. Sci Rep. 2017 07 21; 7(1):6110. Chen IS, Furutani K, Kurachi Y. PMID: 28733581; PMCID: PMC5522400.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research. NPJ Syst Biol Appl. 2017; 3:1. Furutani K, Tsumoto K, Kurachi Y, for HD physiology project investigators. PMID: 28649429; PMCID: PMC5445586.
      View in: PubMed   Mentions: 3     Fields:    
    12. The Possible Role of TASK Channels in Rank-Ordered Recruitment of Motoneurons in the Dorsolateral Part of the Trigeminal Motor Nucleus. eNeuro. 2016 May-Jun; 3(3). Okamoto K, Emura N, Sato H, Fukatsu Y, Saito M, Tanaka C, Morita Y, Nishimura K, Kuramoto E, Xu Yin D, Furutani K, Okazawa M, Kurachi Y, Kaneko T, Maeda Y, Yamashiro T, Takada K, Toyoda H, Kang Y. PMID: 27482536; PMCID: PMC4951569.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach. J Physiol Sci. 2015 Mar; 65(2):195-200. Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y. PMID: 25585963.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    14. RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. J Physiol. 2014 Mar 15; 592(6):1237-48. Chen IS, Furutani K, Inanobe A, Kurachi Y. PMID: 24421355; PMCID: PMC3961084.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Systems pharmacology for cardiac ion channels. Drug Delivery System. 2014 Jan 1; 29(5):397. Furutani FK, Kurachi KY. .
      View in: Publisher Site   Mentions:
    16. Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. PLoS Genet. 2013; 9(12):e1003983. Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, Kurachi Y, Omori Y, Furukawa T, Tsuda T, Kuwabata S, Mizukami S, Kikuchi K, Miki H. PMID: 24339795; PMCID: PMC3854942.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    17. Pharmacophore modeling for hERG channel facilitation. Biochem Biophys Res Commun. 2012 Feb 03; 418(1):161-6. Yamakawa Y, Furutani K, Inanobe A, Ohno Y, Kurachi Y. PMID: 22244872.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    18. A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. Biochem Biophys Res Commun. 2011 Nov 11; 415(1):141-6. Furutani K, Yamakawa Y, Inanobe A, Iwata M, Ohno Y, Kurachi Y. PMID: 22020101.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    19. Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction. Eur Heart J. 2012 Jun; 33(11):1408-16. Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K. PMID: 21490055.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    20. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev. 2010 Jan; 90(1):291-366. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y. PMID: 20086079.
      View in: PubMed   Mentions: 652     Fields:    Translation:HumansAnimalsCells
    21. Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol. 2009 Jun; 75(6):1287-95. Furutani K, Ohno Y, Inanobe A, Hibino H, Kurachi Y. PMID: 19264848.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    22. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 2007 Apr 04; 26(7):1924-33. Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, Takeshima H. PMID: 17347645; PMCID: PMC1847665.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    23. Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8528-33. Furutani K, Okubo Y, Kakizawa S, Iino M. PMID: 16709674; PMCID: PMC1482525.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2004 Nov; 287(5):G1053-61. Nakamura E, Kataoka T, Furutani K, Jimbo K, Aihara T, Tanaka S, Ichikawa A, Ohtsu H, Okabe S. PMID: 15271653.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice. Gastroenterology. 2003 Dec; 125(6):1774-84. Aihara T, Fujishita T, Kanatani K, Furutani K, Nakamura E, Taketo MM, Matsui M, Chen D, Okabe S. PMID: 14724830.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. J Pharmacol Exp Ther. 2003 Oct; 307(1):331-8. Furutani K, Aihara T, Nakamura E, Tanaka S, Ichikawa A, Ohtsu H, Okabe S. PMID: 12893847.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    27. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacol Ther. 2003 Apr; 98(1):109-27. Aihara T, Nakamura E, Amagase K, Tomita K, Fujishita T, Furutani K, Okabe S. PMID: 12667890.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. [Regulatory mechanism of gastric acid secretion and mucosal integrity--an analysis with various gene deficient mice]. Nihon Yakurigaku Zasshi. 2002 Sep; 120(3):159-71. Okabe S, Furutani K, Maeda K, Aihara T, Fujishita T, Tonai S. PMID: 12271511.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals