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Kevork Hagopian

TitlePROJ SCIENTIST-FY
InstitutionUniversity of California Davis
DepartmentVM: MOLECULAR BIO SCIENCES
AddressCA 95616
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 01; 27(5):1156. PMID: 29719228.
      View in: PubMed
    2. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. PMID: 28877457.
      View in: PubMed
    3. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. PMID: 28133633.
      View in: PubMed
    4. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-85. PMID: 27059956; PMCID: PMC4933453 [Available on 06/10/17].
    5. Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. PMID: 25880638; PMCID: PMC4400099.
    6. Villalba JM, López-Domínguez JA, Chen Y, Khraiwesh H, González-Reyes JA, Del Río LF, Gutiérrez-Casado E, Del Río M, Calvo-Rubio M, Ariza J, de Cabo R, López-Lluch G, Navas P, Hagopian K, Burón MI, Ramsey JJ. The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice. Biogerontology. 2015 Oct; 16(5):655-70. PMID: 25860863; PMCID: PMC4555094 [Available on 10/01/16].
    7. López-Domínguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, Villalba JM, López-Lluch G, Navas P, McDonald RB. The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. J Gerontol A Biol Sci Med Sci. 2015 Oct; 70(10):1181-8. PMID: 25313149; PMCID: PMC4612357 [Available on 10/01/16].
    8. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. PMID: 25257068; PMCID: PMC4244234.
    9. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. PMID: 24336818; PMCID: PMC4172037.
    10. Hagopian K, Soo Hoo R, López-Domínguez JA, Ramsey JJ. Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations. Life Sci. 2013 Dec 05; 93(24):941-8. PMID: 24140885; PMCID: PMC3886717.
    11. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, McDonald RB, Ramsey JJ. The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction. Biosci Rep. 2012 Dec 13; 33(1):83-95. PMID: 23098316; PMCID: PMC3522480.
    12. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. PMID: 22683097; PMCID: PMC3442136.
    13. Chen Y, Hagopian K, McDonald RB, Bibus D, López-Lluch G, Villalba JM, Navas P, Ramsey JJ. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J Gerontol A Biol Sci Med Sci. 2012 Nov; 67(11):1121-31. PMID: 22503990; PMCID: PMC3636677.
    14. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012 Feb; 11(1):162-8. PMID: 22081964.
      View in: PubMed
    15. Hagopian K, Chen Y, Simmons Domer K, Soo Hoo R, Bentley T, McDonald RB, Ramsey JJ. Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver. J Bioenerg Biomembr. 2011 Jun; 43(3):227-36. PMID: 21505800; PMCID: PMC3131738.
    16. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. PMID: 21040401; PMCID: PMC4157392.
    17. Hagopian K, Weber KL, Hwee DT, Van Eenennaam AL, López-Lluch G, Villalba JM, Burón I, Navas P, German JB, Watkins SM, Chen Y, Wei A, McDonald RB, Ramsey JJ. Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. PLoS One. 2010 Sep 13; 5(9):e12696. PMID: 20856881; PMCID: PMC2938348.
    18. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. PMID: 19892704; PMCID: PMC2801244.
    19. Hagopian K, Ramsey JJ, Weindruch R. Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver. Biogerontology. 2009 Aug; 10(4):471-9. PMID: 18953666; PMCID: PMC2700840.
    20. Asami DK, McDonald RB, Hagopian K, Horwitz BA, Warman D, Hsiao A, Warden C, Ramsey JJ. Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice. Exp Gerontol. 2008 Dec; 43(12):1069-76. PMID: 18852040; PMCID: PMC2614627.
    21. Hagopian K, Ramsey JJ, Weindruch R. Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Biosci Rep. 2008 Apr; 28(2):107-15. PMID: 18429748; PMCID: PMC2538689.
    22. Hagopian K. Rat liver xanthine oxidoreductase: effect of adenine on the oxidase and dehydrogenase activities. Ital J Biochem. 2007 Mar; 56(1):6-17. PMID: 17511349.
      View in: PubMed
    23. Ramsey JJ, Hagopian K. Energy expenditure and restriction of energy intake: could energy restriction alter energy expenditure in companion animals? J Nutr. 2006 07; 136(7 Suppl):1958S-1966S. PMID: 16772468.
      View in: PubMed
    24. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab. 2005 Sep; 289(3):E429-38. PMID: 15886224.
      View in: PubMed
    25. Hagopian K, Ramsey JJ, Weindruch R. Serine utilization in mouse liver: influence of caloric restriction and aging. FEBS Lett. 2005 Mar 28; 579(9):2009-13. PMID: 15792811.
      View in: PubMed
    26. Ramsey JJ, Kemnitz JW, Newton W, Hagopian K, Patterson TA, Swick AG. Food intake in rhesus monkeys following central administration of orexins. Regul Pept. 2005 Jan 15; 124(1-3):209-14. PMID: 15544861.
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    27. Ramsey JJ, Harper ME, Humble SJ, Koomson EK, Ram JJ, Bevilacqua L, Hagopian K. Influence of mitochondrial membrane fatty acid composition on proton leak and H2O2 production in liver. Comp Biochem Physiol B Biochem Mol Biol. 2005 Jan; 140(1):99-108. PMID: 15621515.
      View in: PubMed
    28. Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ. Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. Am J Physiol Endocrinol Metab. 2005 Apr; 288(4):E674-84. PMID: 15562252.
      View in: PubMed
    29. Hagopian K, Ramsey JJ, Weindruch R. Fructose metabolizing enzymes from mouse liver: influence of age and caloric restriction. Biochim Biophys Acta. 2005 Jan 18; 1721(1-3):37-43. PMID: 15652177.
      View in: PubMed
    30. Hagopian K, Ramsey JJ, Weindruch R. Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction. Exp Gerontol. 2004 Aug; 39(8):1145-54. PMID: 15288689.
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    31. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab. 2004 May; 286(5):E852-61. PMID: 14736705.
      View in: PubMed
    32. Ramsey JJ, Hagopian K, Kenny TM, Koomson EK, Bevilacqua L, Weindruch R, Harper ME. Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E31-40. PMID: 14662512.
      View in: PubMed
    33. Hagopian K, Ramsey JJ, Weindruch R. Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver. Exp Gerontol. 2003 Mar; 38(3):267-78. PMID: 12581790.
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    34. Hagopian K, Ramsey JJ, Weindruch R. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Exp Gerontol. 2003 Mar; 38(3):253-66. PMID: 12581789.
      View in: PubMed