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Kevork Hagopian

Title(s)Scientist, School of Veterinary Medicine
SchoolUniversity of California, Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2018 May 01; 27(5):1156. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 29719228.
      View in: PubMed   Mentions: 4     Fields:    
    2. The influence of Shc proteins and high-fat diet on energy metabolism of mice. Cell Biochem Funct. 2017 Dec; 35(8):527-537. Baldassini WA, Ramsey JJ, Hagopian K, Lanna DPD. PMID: 29243276.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017 Sep 05; 26(3):539-546.e5. Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA. PMID: 28877457.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    4. Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. 2016 Sep; 7:273-286. Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. PMID: 28133633.
      View in: PubMed   Mentions:
    5. p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10; 291(24):12575-85. Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. PMID: 27059956.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. 2015; 10(4):e0124204. Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. PMID: 25880638.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice. Biogerontology. 2015 Oct; 16(5):655-70. Villalba JM, López-Domínguez JA, Chen Y, Khraiwesh H, González-Reyes JA, Del Río LF, Gutiérrez-Casado E, Del Río M, Calvo-Rubio M, Ariza J, de Cabo R, López-Lluch G, Navas P, Hagopian K, Burón MI, Ramsey JJ. PMID: 25860863.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. J Gerontol A Biol Sci Med Sci. 2015 Oct; 70(10):1181-8. López-Domínguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, Villalba JM, López-Lluch G, Navas P, McDonald RB. PMID: 25313149.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    9. Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. 2014 Dec; 13(6):1049-58. Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. PMID: 25257068.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. 2014 Oct; 69(10):1177-85. Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. PMID: 24336818.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    11. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction. Physiol Res. 2014; 63(1):57-71. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, Ramsey JJ. PMID: 24182343.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations. Life Sci. 2013 Dec 05; 93(24):941-8. Hagopian K, Soo Hoo R, López-Domínguez JA, Ramsey JJ. PMID: 24140885.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction. Biosci Rep. 2012 Dec 13; 33(1):83-95. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, McDonald RB, Ramsey JJ. PMID: 23098316.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    14. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012 Dec; 61(12):1703-13. Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. PMID: 22683097.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. The influence of dietary lipid composition on skeletal muscle mitochondria from mice following 1 month of calorie restriction. J Gerontol A Biol Sci Med Sci. 2012 Nov; 67(11):1121-31. Chen Y, Hagopian K, McDonald RB, Bibus D, López-Lluch G, Villalba JM, Navas P, Ramsey JJ. PMID: 22503990.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    16. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012 Feb; 11(1):162-8. Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. PMID: 22081964.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    17. Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver. J Bioenerg Biomembr. 2011 Jun; 43(3):227-36. Hagopian K, Chen Y, Simmons Domer K, Soo Hoo R, Bentley T, McDonald RB, Ramsey JJ. PMID: 21505800.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. PMID: 21040401.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    19. Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. PLoS One. 2010 Sep 13; 5(9):e12696. Hagopian K, Weber KL, Hwee DT, Van Eenennaam AL, López-Lluch G, Villalba JM, Burón I, Navas P, German JB, Watkins SM, Chen Y, Wei A, McDonald RB, Ramsey JJ. PMID: 20856881.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 2010 Jan 08; 285(2):1153-65. Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. PMID: 19892704.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    21. Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver. Biogerontology. 2009 Aug; 10(4):471-9. Hagopian K, Ramsey JJ, Weindruch R. PMID: 18953666.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice. Exp Gerontol. 2008 Dec; 43(12):1069-76. Asami DK, McDonald RB, Hagopian K, Horwitz BA, Warman D, Hsiao A, Warden C, Ramsey JJ. PMID: 18852040.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Biosci Rep. 2008 Apr; 28(2):107-15. Hagopian K, Ramsey JJ, Weindruch R. PMID: 18429748.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Rat liver xanthine oxidoreductase: effect of adenine on the oxidase and dehydrogenase activities. Ital J Biochem. 2007 Mar; 56(1):6-17. Hagopian K. PMID: 17511349.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. Energy expenditure and restriction of energy intake: could energy restriction alter energy expenditure in companion animals? J Nutr. 2006 07; 136(7 Suppl):1958S-1966S. Ramsey JJ, Hagopian K. PMID: 16772468.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    26. Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am J Physiol Endocrinol Metab. 2005 Sep; 289(3):E429-38. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. PMID: 15886224.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    27. Serine utilization in mouse liver: influence of caloric restriction and aging. FEBS Lett. 2005 Mar 28; 579(9):2009-13. Hagopian K, Ramsey JJ, Weindruch R. PMID: 15792811.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Food intake in rhesus monkeys following central administration of orexins. Regul Pept. 2005 Jan 15; 124(1-3):209-14. Ramsey JJ, Kemnitz JW, Newton W, Hagopian K, Patterson TA, Swick AG. PMID: 15544861.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Influence of mitochondrial membrane fatty acid composition on proton leak and H2O2 production in liver. Comp Biochem Physiol B Biochem Mol Biol. 2005 Jan; 140(1):99-108. Ramsey JJ, Harper ME, Humble SJ, Koomson EK, Ram JJ, Bevilacqua L, Hagopian K. PMID: 15621515.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand. 2004 Dec; 182(4):321-31. Harper ME, Bevilacqua L, Hagopian K, Weindruch R, Ramsey JJ. PMID: 15569093.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria. Am J Physiol Endocrinol Metab. 2005 Apr; 288(4):E674-84. Hagopian K, Harper ME, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ. PMID: 15562252.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    32. Fructose metabolizing enzymes from mouse liver: influence of age and caloric restriction. Biochim Biophys Acta. 2005 Jan 18; 1721(1-3):37-43. Hagopian K, Ramsey JJ, Weindruch R. PMID: 15652177.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    33. Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction. Exp Gerontol. 2004 Aug; 39(8):1145-54. Hagopian K, Ramsey JJ, Weindruch R. PMID: 15288689.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab. 2004 May; 286(5):E852-61. Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME. PMID: 14736705.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    35. Proton leak and hydrogen peroxide production in liver mitochondria from energy-restricted rats. Am J Physiol Endocrinol Metab. 2004 Jan; 286(1):E31-40. Ramsey JJ, Hagopian K, Kenny TM, Koomson EK, Bevilacqua L, Weindruch R, Harper ME. PMID: 14662512.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Exp Gerontol. 2003 Mar; 38(3):253-66. Hagopian K, Ramsey JJ, Weindruch R. PMID: 12581789.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver. Exp Gerontol. 2003 Mar; 38(3):267-78. Hagopian K, Ramsey JJ, Weindruch R. PMID: 12581790.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    38. Preparative electrophoretic method for the purification of a hydrophobic membrane protein: subunit c of the mitochondrial ATP synthase from rat liver. Anal Biochem. 1999 Sep 10; 273(2):240-51. Hagopian K. PMID: 10469495.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Antioxid Redox Signal. 1999; 1(1):71-81. Ripple MO, Hagopian K, Oberley TD, Schatten H, Weindruch R. PMID: 11225734.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    40. Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe. J Biol Chem. 1998 Feb 20; 273(8):4681-8. Jiang F, Kelly BL, Hagopian K, Greenberg ML. PMID: 9468529.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. The role of pyruvate dehydrogenase, phosphofructo-1-kinase and acetyl-CoA carboxylase in the regulation of fatty acid synthesis in the lactating rat mammary gland during the starved to re-fed transition. Biochim Biophys Acta. 1997 Oct 20; 1336(3):474-84. Hagopian K, Munday MR. PMID: 9367175.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    42. Late-infantile Batten disease: purification of the subunit c of the mitochondrial ATP synthase from storage material. Am J Med Genet. 1995 Jun 05; 57(2):272-8. Hagopian K, Lake BD, Winchester BG, Clark JB. PMID: 7668344.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    43. Regulation of fatty acid synthesis in lactating rat mammary gland in the fed to starved transition: asynchronous control of pyruvate dehydrogenase, phosphofructokinase and acetyl-CoA carboxylase. Comp Biochem Physiol B. 1991; 100(3):527-34. Hagopian K, Butt J, Munday MR. PMID: 1687675.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals