Leigh G Griffiths

Title(s)Associate Professor, School of Veterinary Medicine
SchoolUniversity of California, Davis
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    1. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2022 Jan 12. Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. PMID: 35022664.
      View in: PubMed   Mentions:
    2. Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection. Transplantation. 2021 12 17. Gates KV, Panicker AJ, Biendarra-Tiegs SM, Vetr NG, Lopera Higuita M, Nelson TJ, Pereira NL, Griffiths LG. PMID: 34923540.
      View in: PubMed   Mentions:
    3. Impact of calcific aortic valve disease on valve mechanics. Biomech Model Mechanobiol. 2022 Feb; 21(1):55-77. Vogl BJ, Niemi NR, Griffiths LG, Alkhouli MA, Hatoum H. PMID: 34687365.
      View in: PubMed   Mentions:
    4. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng. 2021 10; 5(10):1131-1142. Yuk H, Wu J, Sarrafian TL, Mao X, Varela CE, Roche ET, Griffiths LG, Nabzdyk CS, Zhao X. PMID: 34373600.
      View in: PubMed   Mentions:
    5. Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. Proteomics Clin Appl. 2021 Jul; 15(4):e2170034. Gates KV, Xing Q, Griffiths LG. PMID: 34288511.
      View in: PubMed   Mentions:    Fields:    
    6. Tissue engineered bovine saphenous vein extracellular matrix scaffolds produced via antigen removal achieve high in vivo patency rates. Acta Biomater. 2021 10 15; 134:144-159. Lopera Higuita M, Lopera Giraldo JF, Sarrafian TL, Griffiths LG. PMID: 34192567; PMCID: PMC8542604.
      View in: PubMed   Mentions:
    7. Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. Sci Rep. 2021 02 25; 11(1):4607. Xing Q, Parvizi M, Lopera Higuita M, Griffiths LG. PMID: 33633241; PMCID: PMC7907089.
      View in: PubMed   Mentions: 2     Fields:    
    8. FLIm-Guided Raman Imaging to Study Cross-Linking and Calcification of Bovine Pericardium. Anal Chem. 2020 08 04; 92(15):10659-10667. Shaik TA, Alfonso-García A, Zhou X, Arnold KM, Haudenschild AK, Krafft C, Griffiths LG, Popp J, Marcu L. PMID: 32598134; PMCID: PMC7539574.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. Antigen removal process preserves function of small diameter venous valved conduits, whereas SDS-decellularization results in significant valvular insufficiency. Acta Biomater. 2020 04 15; 107:115-128. Lopera Higuita M, Griffiths LG. PMID: 32151701; PMCID: PMC7164717.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications. Tissue Eng Part B Rev. 2020 02; 26(1):26-45. Lopera Higuita M, Griffiths LG. PMID: 31663438; PMCID: PMC7041331.
      View in: PubMed   Mentions:
    11. Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. Sci Rep. 2019 11 13; 9(1):16688. Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L. PMID: 31723198; PMCID: PMC6853938.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. Methods Appl Fluoresc. 2019 Sep 20; 7(4):044003. Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L, Panitch A, Marcu L. PMID: 31505471; PMCID: PMC7539617.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Effect of cyclic deformation on xenogeneic heart valve biomaterials. PLoS One. 2019; 14(6):e0214656. Dalgliesh AJ, Parvizi M, Noble C, Griffiths LG. PMID: 31194770; PMCID: PMC6563958.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. Proteomics Clin Appl. 2019 07; 13(4):e1800129. Gates KV, Xing Q, Griffiths LG. PMID: 30548925; PMCID: PMC6565515.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. Graft-specific immune tolerance is determined by residual antigenicity of xenogeneic extracellular matrix scaffolds. Acta Biomater. 2018 10 01; 79:253-264. Dalgliesh AJ, Parvizi M, Lopera-Higuita M, Shklover J, Griffiths LG. PMID: 30130615; PMCID: PMC6349227.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. Ann Biomed Eng. 2018 Nov; 46(11):1870-1881. Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG, Marcu L. PMID: 30003502; PMCID: PMC7700017.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs. J Biophotonics. 2018 09; 11(9):e201700391. Alfonso-Garcia A, Shklover J, Sherlock BE, Panitch A, Griffiths LG, Marcu L. PMID: 29781171; PMCID: PMC7700018.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Chronic graft-specific cell-mediated immune response toward candidate xenogeneic biomaterial. Immunol Res. 2018 04; 66(2):288-298. Gates KV, Griffiths LG. PMID: 29446013.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. PMID: 29531045; PMCID: PMC5879679.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    20. Cardiac Non-Human Leukocyte Antigen Identification: Techniques and Troubles. Front Immunol. 2017; 8:1332. Gates KV, Pereira NL, Griffiths LG. PMID: 29093713; PMCID: PMC5651233.
      View in: PubMed   Mentions: 5     Fields:    
    21. Antigenicity of Bovine Pericardium Determined by a Novel Immunoproteomic Approach. Sci Rep. 2017 05 26; 7(1):2446. Gates KV, Dalgliesh AJ, Griffiths LG. PMID: 28550302; PMCID: PMC5446425.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Magnesium Presence Prevents Removal of Antigenic Nuclear-Associated Proteins from Bovine Pericardium for Heart Valve Engineering. Tissue Eng Part A. 2017 07; 23(13-14):609-621. Dalgliesh AJ, Liu ZZ, Griffiths LG. PMID: 28178887; PMCID: PMC5549833.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Effect of bovine pericardial extracellular matrix scaffold niche on seeded human mesenchymal stem cell function. Sci Rep. 2016 11 15; 6:37089. Liu ZZ, Wong ML, Griffiths LG. PMID: 27845391; PMCID: PMC5109049.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Xenogeneic cardiac extracellular matrix scaffolds with or without seeded mesenchymal stem cells exhibit distinct in vivo immunosuppressive and regenerative properties. Acta Biomater. 2016 11; 45:155-168. Papalamprou A, Chang CW, Vapniarsky N, Clark A, Walker N, Griffiths LG. PMID: 27445086.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Effect of Urea and Thiourea on Generation of Xenogeneic Extracellular Matrix Scaffolds for Tissue Engineering. Tissue Eng Part C Methods. 2016 07; 22(7):700-7. Wong ML, Wong JL, Horn RM, Sannajust KC, Rice DA, Griffiths LG. PMID: 27230226; PMCID: PMC4943467.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Mesenchymal Stem Cell Seeding of Porcine Small Intestinal Submucosal Extracellular Matrix for Cardiovascular Applications. PLoS One. 2016; 11(4):e0153412. Chang CW, Petrie T, Clark A, Lin X, Sondergaard CS, Griffiths LG. PMID: 27070546; PMCID: PMC4829265.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. In vivo xenogeneic scaffold fate is determined by residual antigenicity and extracellular matrix preservation. Biomaterials. 2016 Jun; 92:1-12. Wong ML, Wong JL, Vapniarsky N, Griffiths LG. PMID: 27031928; PMCID: PMC5289067.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Companion animals: Translational scientist's new best friends. Sci Transl Med. 2015 Oct 07; 7(308):308ps21. Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. PMID: 26446953; PMCID: PMC4806851.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    29. Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications. Proteomics Clin Appl. 2016 Jan; 10(1):39-50. Chang CW, Dalgliesh AJ, López JE, Griffiths LG. PMID: 26200932; PMCID: PMC4703519.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Cardiac Extracellular Matrix Scaffold Generated Using Sarcomeric Disassembly and Antigen Removal. Ann Biomed Eng. 2016 Apr; 44(4):1047-60. Papalamprou A, Griffiths LG. PMID: 26215309.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction. J Transl Med. 2015 Jun 06; 13:187. Hanes DW, Wong ML, Jenny Chang CW, Humphrey S, Grayson JK, Boyd WD, Griffiths LG. PMID: 26047812; PMCID: PMC4634919.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    32. Effect of pimobendan on the incidence of arrhythmias in small breed dogs with myxomatous mitral valve degeneration. J Vet Cardiol. 2015 Jun; 17(2):120-8. Lake-Bakaar GA, Singh MK, Kass PH, Griffiths LG. PMID: 26007710.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    33. Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts. J Biomed Opt. 2014 Aug; 19(8):080503. Fatakdawala H, Griffiths LG, Humphrey S, Marcu L. PMID: 25147960; PMCID: PMC4407666.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    34. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102(12):4480-90. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. PMID: 24616346; PMCID: PMC4145060.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater. 2014 May; 10(5):1806-16. Wong ML, Griffiths LG. PMID: 24486910; PMCID: PMC3976714.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    36. Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts. J Biomech. 2014 Jun 27; 47(9):1987-96. Cissell DD, Hu JC, Griffiths LG, Athanasiou KA. PMID: 24268315; PMCID: PMC4014533.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering. Acta Biomater. 2013 May; 9(5):6492-501. Wong ML, Wong JL, Athanasiou KA, Griffiths LG. PMID: 23321301.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    38. Aortic thrombosis in dogs: 31 cases (2000-2010). J Am Vet Med Assoc. 2012 Oct 01; 241(7):910-5. Lake-Bakaar GA, Johnson EG, Griffiths LG. PMID: 23013504.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    39. Aortopulmonary window characterized with two- and three-dimensional echocardiogram in a dog. J Vet Cardiol. 2012; 14(2):371-5. Jung S, Orvalho J, Griffiths LG. PMID: 22609088.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011 Nov; 32(32):8129-38. Wong ML, Leach JK, Athanasiou KA, Griffiths LG. PMID: 21810537.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    41. Echocardiographic assessment of interventricular and intraventricular mechanical synchrony in normal dogs. J Vet Cardiol. 2011 Jun; 13(2):115-26. Griffiths LG, Fransioli JR, Chigerwe M. PMID: 21641290.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    42. Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome. J Vet Cardiol. 2011 Jun; 13(2):91-9. Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon JA, Carter L, Orton EC. PMID: 21640677.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. ECG of the Month. Atrial fibrillation. J Am Vet Med Assoc. 2011 May 15; 238(10):1258-60. Jung S, Griffiths LG. PMID: 21568768.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    44. Surgery for cardiac disease in small animals: current techniques. Vet Clin North Am Small Anim Pract. 2010 Jul; 40(4):605-22. Griffiths LG. PMID: 20610014.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    45. Transvenous occlusion of patent ductus arteriosus in 56 consecutive dogs. J Vet Cardiol. 2010 Aug; 12(2):75-84. Blossom JE, Bright JM, Griffiths LG. PMID: 20594928.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    46. Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue. Electrophoresis. 2008 Nov; 29(22):4508-15. Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC. PMID: 18985661; PMCID: PMC2791994.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    47. Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials. 2008 Sep; 29(26):3514-20. Griffiths LG, Choe LH, Reardon KF, Dow SW, Christopher Orton E. PMID: 18514307; PMCID: PMC2518324.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    48. Transcatheter intravascular stent placement to relieve supravalvular pulmonic stenosis. J Vet Cardiol. 2006 Nov; 8(2):145-55. Griffiths LG, Bright JM, Chan KC. PMID: 19083348.
      View in: PubMed   Mentions: 1     Fields:    
    49. Decellularization of bovine pericardium for tissue-engineering by targeted removal of xenoantigens. J Heart Valve Dis. 2005 Mar; 14(2):212-7. Gonçalves AC, Griffiths LG, Anthony RV, Orton EC. PMID: 15792182.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    50. Evaluation of techniques and outcomes of mitral valve repair in dogs. J Am Vet Med Assoc. 2004 Jun 15; 224(12):1941-5. Griffiths LG, Orton EC, Boon JA. PMID: 15230448.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    51. Ultrasonography versus radiography for detection of fluid in the canine tympanic bulla. Vet Radiol Ultrasound. 2003 Mar-Apr; 44(2):210-3. Griffiths LG, Sullivan M, O'Neill T, Reid SW. PMID: 12718358.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals