Leighton T Izu

Title(s)Professor, Pharmacology
SchoolSchool of Medicine
Phone530-752-0324
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanics and Energetics in Cardiac Arrhythmias and Heart Failure
    NIH R13HL139086Feb 15, 2018 - Jan 31, 2019
    Role: Co-Principal Investigator
    Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias
    NIH R13HL110618Apr 1, 2012 - Mar 31, 2013
    Role: Co-Principal Investigator
    Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System in
    NIH/NHLBI R01HL090880Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Calcium Waves in Atrial Cells
    NIH/NHLBI K25HL068704Jan 22, 2002 - Nov 30, 2006
    Role: Principal Investigator
    UNITARY CALCIUM CURRENTS TRIGGER CALCIUM SPARKS
    NIH/NHLBI F32HL009651May 31, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MapperPlus: Agnostic clustering of high-dimension data for precision medicine. PLOS Digit Health. 2023 Aug; 2(8):e0000307. Datta E, Ballal A, López JE, Izu LT. PMID: 37556425; PMCID: PMC10411786.
      View in: PubMed   Mentions:
    2. On QSAR-based cardiotoxicity modeling with the expressiveness-enhanced graph learning model and dual-threshold scheme. Front Physiol. 2023; 14:1156286. Wang H, Zhu G, Izu LT, Chen-Izu Y, Ono N, Altaf-Ul-Amin MD, Kanaya S, Huang M. PMID: 37228825; PMCID: PMC10203956.
      View in: PubMed   Mentions: 1  
    3. INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions. Physiol Mini Rev. 2023 May-Jun; 16(3):22-34. Chen-Izu Y, Hegyi B, Jian Z, Horvath B, Shaw JA, Banyasz T, Izu LT. PMID: 38107545; PMCID: PMC10722976.
      View in: PubMed   Mentions:
    4. A training pipeline of an arrhythmia classifier for atrial fibrillation detection using Photoplethysmography signal. Front Physiol. 2023; 14:1084837. Kudo S, Chen Z, Zhou X, Izu LT, Chen-Izu Y, Zhu X, Tamura T, Kanaya S, Huang M. PMID: 36744032; PMCID: PMC9892629.
      View in: PubMed   Mentions: 2  
    5. Erratum: Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback. iScience. 2022 Sep 16; 25(9):104810. Kazemi-Lari MA, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw JA, Wineman AS, Chen-Izu Y. PMID: 36034223; PMCID: PMC9399277.
      View in: PubMed   Mentions:
    6. Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback. iScience. 2022 Jul 15; 25(7):104667. Kazemi-Lari MA, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw JA, Wineman AS, Chen-Izu Y. PMID: 35860762; PMCID: PMC9289640.
      View in: PubMed   Mentions: 1  
    7. Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique. Front Physiol. 2022; 13:864002. Horváth B, Szentandrássy N, Dienes C, Kovács ZM, Nánási PP, Chen-Izu Y, Izu LT, Banyasz T. PMID: 35370800; PMCID: PMC8966222.
      View in: PubMed   Mentions: 1  
    8. Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Hegyi B, Shimkunas R, Jian Z, Izu LT, Bers DM, Chen-Izu Y. PMID: 34326268; PMCID: PMC8346795.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. A viscoelastic Eshelby inclusion model and analysis of the Cell-in-Gel system. Int J Eng Sci. 2021 Aug 01; 165. Kazemi-Lari MA, Shaw JA, Wineman AS, Shimkunas R, Jian Z, Hegyi B, Izu L, Chen-Izu Y. PMID: 34629507; PMCID: PMC8500226.
      View in: PubMed   Mentions: 4  
    10. Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes. Life (Basel). 2021 May 29; 11(6). Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, Shaw J, Banyasz T, Chen-Izu Y. PMID: 34072584; PMCID: PMC8227646.
      View in: PubMed   Mentions: 3  
    11. Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte. Circ Res. 2021 03 19; 128(6):772-774. Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. PMID: 33601939; PMCID: PMC7979518.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Balance Between Rapid Delayed Rectifier K+ Current and Late Na+ Current on Ventricular Repolarization: An Effective Antiarrhythmic Target? Circ Arrhythm Electrophysiol. 2020 04; 13(4):e008130. Hegyi B, Chen-Izu Y, Izu LT, Rajamani S, Belardinelli L, Bers DM, Bányász T. PMID: 32202931; PMCID: PMC7331791.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. J Physiol. 2020 04; 598(7):1285-1305. Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. PMID: 31789427; PMCID: PMC7127983.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    14. Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice. Sci Rep. 2019 08 20; 9(1):12128. Lee JH, Park S, Perez-Flores MC, Wang W, Kim HJ, Izu L, Gratton MA, Chiamvimonvat N, Yamoah EN. PMID: 31431657; PMCID: PMC6702171.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and β-adrenergic stimulation. Can J Physiol Pharmacol. 2019 Aug; 97(8):773-780. Hegyi B, Chen-Izu Y, Izu LT, Bányász T. PMID: 31091413; PMCID: PMC10286692.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and β-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336; PMCID: PMC6720130.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    17. β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018 10; 123:168-179. Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y. PMID: 30240676; PMCID: PMC6201263.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    18. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 03 16; 8(1):4670. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. PMID: 29549309; PMCID: PMC5856806.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    19. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. PMID: 29531045; PMCID: PMC5879679.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    20. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005852. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. PMID: 29437761; PMCID: PMC5813707.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    21. Avoiding phantasms. Cardiovasc Res. 2017 12 01; 113(14):1703-1704. Coulibaly Z, Chen-Izu Y, Izu LT. PMID: 29036639; PMCID: PMC5852615.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. PMID: 29025768; PMCID: PMC5662469.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 08; 109:27-37. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu LT, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N. PMID: 28668303; PMCID: PMC5995131.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Mechano-chemo-transduction in cardiac myocytes. J Physiol. 2017 06 15; 595(12):3949-3958. Chen-Izu Y, Izu LT. PMID: 28098356; PMCID: PMC5471413.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. PMID: 27808412; PMCID: PMC5374105.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    26. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu LT. PMID: 27653489; PMCID: PMC5034366.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. PMID: 27500929; PMCID: PMC4976940.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Optimizing Population Variability to Maximize Benefit. PLoS One. 2015; 10(12):e0143475. Izu LT, Bányász T, Chen-Izu Y. PMID: 26650247; PMCID: PMC4674128.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875; PMCID: PMC4740258.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):173-6. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu LT, Banyasz T. PMID: 26463508; PMCID: PMC4689637.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    31. Measuring the metrics: Correlating t-tubule structure and muscle contraction in the intact heart. J Mol Cell Cardiol. 2015 Aug; 85:153-4. Chen-Izu Y, Izu LT. PMID: 26031703.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. PMID: 25772289; PMCID: PMC4376414.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    33. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    34. An emerging antiarrhythmic target: late sodium current. Curr Pharm Des. 2015; 21(8):1073-90. Banyasz T, Szentandrássy N, Magyar J, Szabo Z, Nánási PP, Chen-Izu Y, Izu LT. PMID: 25354179.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    35. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. PMID: 24643800; PMCID: PMC4103414.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    36. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys J. 2014 Mar 18; 106(6):1391-7. Xie Y, Izu LT, Bers DM, Sato D. PMID: 24655514; PMCID: PMC3984988.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov; 466(11):2067-76. Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu LT, Chen-Izu Y. PMID: 24535581; PMCID: PMC4138296.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    38. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar; 68:1-11. Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH. PMID: 24389341; PMCID: PMC3942534.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    39. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. PMID: 24323672; PMCID: PMC3954117.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    40. Mechanical analysis of single myocyte contraction in a 3-D elastic matrix. PLoS One. 2013; 8(10):e75492. Shaw J, Izu L, Chen-Izu Y. PMID: 24098388; PMCID: PMC3789722.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    41. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol. 2013 Nov; 64:59-68. Horvath B, Banyasz T, Jian Z, Hegyi B, Kistamas K, Nanasi PP, Izu LT, Chen-Izu Y. PMID: 24012538; PMCID: PMC3856763.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    42. Ca²⁺ waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. Izu LT, Xie Y, Sato D, Bányász T, Chen-Izu Y. PMID: 23220129; PMCID: PMC3660086.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    43. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood. 2012 Dec 20; 120(26):5209-16. Jonnalagadda D, Izu LT, Whiteheart SW. PMID: 23086755; PMCID: PMC3537312.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    44. Une cellule type? J Mol Cell Cardiol. 2012 May; 52(5):921-2. Izu LT, Chen-Izu Y. PMID: 22326436; PMCID: PMC3727390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    45. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes. Heart Rhythm. 2012 Jan; 9(1):134-42. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. PMID: 21884673; PMCID: PMC3252888.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    46. Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol. 2011 Mar; 50(3):578-81. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. PMID: 21215755; PMCID: PMC3047417.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    47. Cellular cartography. Biophys J. 2010 Dec 15; 99(12):3861-2. Chen-Izu Y, Izu LT. PMID: 21156126; PMCID: PMC3000499.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    48. Calcium handling in human embryonic stem cell-derived cardiomyocytes. Stem Cells. 2008 Aug; 26(8):1961-72. Satin J, Itzhaki I, Rapoport S, Schroder EA, Izu L, Arbel G, Beyar R, Balke CW, Schiller J, Gepstein L. PMID: 18483424.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    49. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol. 2008 Mar; 93(3):370-82. Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu LT, Balke CW. PMID: 18156167.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    50. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3301-10. Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, Izu LT, Balke CW. PMID: 17873027.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    51. Eavesdropping on the social lives of Ca(2+) sparks. Biophys J. 2007 Nov 15; 93(10):3408-20. Izu LT, Bányász T, Balke CW, Chen-Izu Y. PMID: 17675349; PMCID: PMC2072070.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    52. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. PMID: 17630346.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    53. A new approach to the detection and statistical classification of Ca2+ sparks. Biophys J. 2007 Jun 15; 92(12):4458-65. Bányász T, Chen-Izu Y, Balke CW, Izu LT. PMID: 17400702; PMCID: PMC1877760.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    54. Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J. 2006 Jul 01; 91(1):95-112. Izu LT, Means SA, Shadid JN, Chen-Izu Y, Balke CW. PMID: 16603499; PMCID: PMC1479049.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    55. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006 Jul 01; 91(1):1-13. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu LT. PMID: 16603500; PMCID: PMC1479079.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    56. A memory-efficient finite element method for systems of reaction–diffusion equations with non-smooth forcing. Journal of Computational and Applied Mathematics. 2004 Aug 1; 169(2):431-458. Hanhart HA, Gobbert GM, Izu IL. .
      View in: Publisher Site   Mentions:
    57. Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003 Mar 01; 547(Pt 2):441-51. Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. PMID: 12562899; PMCID: PMC2342655.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    58. The Ca2+ synapse redo: a matter of location, location, location. Circ Res. 2002 Aug 23; 91(4):276-7. Izu LT, William Balke C. PMID: 12193458.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    59. Vasoactive intestinal peptide-stimulated Cl- secretion: activation of cAMP-dependent K+ channels. J Membr Biol. 2002 Apr 01; 186(3):145-57. Izu LT, McCulle SL, Ferreri-Jacobia MT, Devor DC, Duffey ME. PMID: 12148841.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    60. Evolution of cardiac calcium waves from stochastic calcium sparks. Biophys J. 2001 Jan; 80(1):103-20. Izu LT, Wier WG, Balke CW. PMID: 11159386; PMCID: PMC1301217.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    61. Large currents generate cardiac Ca2+ sparks. Biophys J. 2001 Jan; 80(1):88-102. Izu LT, Mauban JR, Balke CW, Wier WG. PMID: 11159385; PMCID: PMC1301216.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    62. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J. 2000 Nov; 79(5):2547-56. Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. PMID: 11053129; PMCID: PMC1301137.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    63. Theoretical analysis of the Ca2+ spark amplitude distribution. Biophys J. 1998 Sep; 75(3):1144-62. Izu LT, Wier WG, Balke CW. PMID: 9726917; PMCID: PMC1299790.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    64. Ca2+ sparks triggered by patch depolarization in rat heart cells. Circ Res. 1998 Mar 09; 82(4):424-9. Shorofsky SR, Izu L, Wier WG, Balke CW. PMID: 9506702.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    65. Downregulation of a human colonic sialyltransferase by a secondary bile acid and a phorbol ester. Am J Physiol. 1998 03; 274(3):G599-606. Li M, Vemulapalli R, Ullah A, Izu L, Duffey ME, Lance P. PMID: 9530163.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    66. G proteins activate ionic conductances at multiple sites in T84 cells. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1222-31. Izu L, Li M, DeMuro R, Duffey ME. PMID: 9142847.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    67. A class of parametrically excited calcium oscillation detectors. Biophys J. 1995 Apr; 68(4):1621-9. Izu LT, Spangler RA. PMID: 7787048; PMCID: PMC1282058.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    68. Chronic ethanol exposure inhibits ATP-stimulated but not KCl-stimulated dopamine release in PC 12 cells. J Pharmacol Exp Ther. 1994 Jul; 270(1):336-41. Kim WK, Johnson RG, Izu LT, Rabin RA. PMID: 8035329.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    69. The DINE microcomputer program: an innovative curricular approach. Health Educ. 1983 Mar-Apr; 14(2):44-7. Dennison D, Frauenheim KA, Izu L. PMID: 6443908.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    70. [Evolution of systolic time intervals after prolonged opotherapy in hypothyroid patients]. Boll Soc Ital Cardiol. 1981; 26(4):345-52. Montaldo PL, Loddo M, Multineddu R, Petrini L, Fois M, Pisano MR, Satta L, Lixi M, Leo P, Isu L. PMID: 7340868.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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