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Leighton T Izu

TitleASSOC PROF-HCOMP
InstitutionUniversity of California Davis
DepartmentMED: PHARMACOLOGY
Address1275 Med Sci Drive
CA 95616
Phone530-752-0324
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanics and Energetics in Cardiac Arrhythmias and Heart Failure
    NIH/NHLBI R13HL139086Feb 15, 2018 - Jan 31, 2019
    Role: Co-Principal Investigator
    Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias
    NIH/NHLBI R13HL110618Apr 1, 2012 - Mar 31, 2013
    Role: Co-Principal Investigator
    Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System in
    NIH/NHLBI R01HL090880Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Calcium Waves in Atrial Cells
    NIH/NHLBI K25HL068704Jan 22, 2002 - Nov 30, 2006
    Role: Principal Investigator
    UNITARY CALCIUM CURRENTS TRIGGER CALCIUM SPARKS
    NIH/NHLBI F32HL009651May 31, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu L, Chiamvimonvat N. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 Mar 16; 8(1):4670. PMID: 29549309.
      View in: PubMed
    2. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu L, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13):E3036-E3044. PMID: 29531045.
      View in: PubMed
    3. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu L, Chen-Izu Y, Bers DM. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and ß-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 Feb; 11(2):e005852. PMID: 29437761.
      View in: PubMed
    4. Coulibaly Z, Chen-Izu Y, Izu L. Avoiding phantasms. Cardiovasc Res. 2017 Dec 01; 113(14):1703-1704. PMID: 29036639.
      View in: PubMed
    5. Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu L, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). PMID: 29025768.
      View in: PubMed
    6. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu L, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 Aug; 109:27-37. PMID: 28668303.
      View in: PubMed
    7. Chen-Izu Y, Izu L. Mechano-chemo-transduction in cardiac myocytes. J Physiol. 2017 Jun 15; 595(12):3949-3958. PMID: 28098356.
      View in: PubMed
    8. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 Apr 01; 595(7):2229-2252. PMID: 27808412.
      View in: PubMed
    9. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu L. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. PMID: 27653489.
      View in: PubMed
    10. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu L, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. PMID: 27500929.
      View in: PubMed
    11. Izu L, Bányász T, Chen-Izu Y. Optimizing Population Variability to Maximize Benefit. PLoS One. 2015; 10(12):e0143475. PMID: 26650247.
      View in: PubMed
    12. Awasthi S, Izu L, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood B, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 Jan 22; 118(2):e19-28. PMID: 26643875; PMCID: PMC4740258 [Available on 01/22/17].
    13. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu L, Banyasz T. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):173-6. PMID: 26463508.
      View in: PubMed
    14. Chen-Izu Y, Izu L. Measuring the metrics: Correlating t-tubule structure and muscle contraction in the intact heart. J Mol Cell Cardiol. 2015 Aug; 85:153-4. PMID: 26031703.
      View in: PubMed
    15. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu L, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
      View in: PubMed
    16. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289; PMCID: PMC4376414.
    17. Jian Z, Han H, Zhang T, Puglisi J, Izu L, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. PMID: 24643800; PMCID: PMC4103414.
    18. Xie Y, Izu L, Bers DM, Sato D. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys J. 2014 Mar 18; 106(6):1391-7. PMID: 24655514; PMCID: PMC3984988.
    19. Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu L, Chen-Izu Y. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov; 466(11):2067-76. PMID: 24535581; PMCID: PMC4138296.
    20. Torres NS, Sachse FB, Izu L, Goldhaber JI, Spitzer KW, Bridge JH. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar; 68:1-11. PMID: 24389341.
      View in: PubMed
    21. Shaw J, Izu L, Chen-Izu Y. Mechanical analysis of single myocyte contraction in a 3-D elastic matrix. PLoS One. 2013; 8(10):e75492. PMID: 24098388; PMCID: PMC3789722.
    22. Horvath B, Banyasz T, Jian Z, Hegyi B, Kistamas K, Nanasi PP, Izu L, Chen-Izu Y. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol. 2013 Nov; 64:59-68. PMID: 24012538; PMCID: PMC3856763.
    23. Izu L, Xie Y, Sato D, Bányász T, Chen-Izu Y. Ca²? waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. PMID: 23220129.
      View in: PubMed
    24. Izu L, Chen-Izu Y. Une cellule type? J Mol Cell Cardiol. 2012 May; 52(5):921-2. PMID: 22326436; PMCID: PMC3727390.
    25. Banyasz T, Horvath B, Jian Z, Izu L, Chen-Izu Y. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes. Heart Rhythm. 2012 Jan; 9(1):134-42. PMID: 21884673; PMCID: PMC3252888.
    26. Banyasz T, Horvath B, Jian Z, Izu L, Chen-Izu Y. Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol. 2011 Mar; 50(3):578-81. PMID: 21215755; PMCID: PMC3047417.
    27. Chen-Izu Y, Izu L. Cellular cartography. Biophys J. 2010 Dec 15; 99(12):3861-2. PMID: 21156126; PMCID: PMC3000499.
    28. Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu L, Balke CW. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol. 2008 Mar; 93(3):370-82. PMID: 18156167.
      View in: PubMed
    29. Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, Izu L, Balke CW. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3301-10. PMID: 17873027.
      View in: PubMed
    30. Izu L, Bányász T, Balke CW, Chen-Izu Y. Eavesdropping on the social lives of Ca(2+) sparks. Biophys J. 2007 Nov 15; 93(10):3408-20. PMID: 17675349; PMCID: PMC2072070.
    31. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu L, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. PMID: 17630346.
      View in: PubMed
    32. Bányász T, Chen-Izu Y, Balke CW, Izu L. A new approach to the detection and statistical classification of Ca2+ sparks. Biophys J. 2007 Jun 15; 92(12):4458-65. PMID: 17400702; PMCID: PMC1877760.
    33. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu L. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006 Jul 01; 91(1):1-13. PMID: 16603500; PMCID: PMC1479079.
    34. Izu L, Means SA, Shadid JN, Chen-Izu Y, Balke CW. Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J. 2006 Jul 01; 91(1):95-112. PMID: 16603499; PMCID: PMC1479049.
    35. Kirk MM, Izu L, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003 Mar 01; 547(Pt 2):441-51. PMID: 12562899; PMCID: PMC2342655.
    36. Izu L, William Balke C. The Ca2+ synapse redo: a matter of location, location, location. Circ Res. 2002 Aug 23; 91(4):276-7. PMID: 12193458.
      View in: PubMed