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Leighton T Izu

Title(s)Associate Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-0324
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    Collapse Research Activities and Funding
    Mechanics and Energetics in Cardiac Arrhythmias and Heart Failure
    NIH/NHLBI R13HL139086Feb 15, 2018 - Jan 31, 2019
    Role: Co-Principal Investigator
    Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias
    NIH/NHLBI R13HL110618Apr 1, 2012 - Mar 31, 2013
    Role: Co-Principal Investigator
    Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System in
    NIH/NHLBI R01HL090880Jul 1, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Calcium Waves in Atrial Cells
    NIH/NHLBI K25HL068704Jan 22, 2002 - Nov 30, 2006
    Role: Principal Investigator
    UNITARY CALCIUM CURRENTS TRIGGER CALCIUM SPARKS
    NIH/NHLBI F32HL009651May 31, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. J Physiol. 2019 Dec 02. PMID: 31789427.
      View in: PubMed
    2. Lee JH, Park S, Perez-Flores MC, Wang W, Kim HJ, Izu L, Gratton MA, Chiamvimonvat N, Yamoah EN. Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice. Sci Rep. 2019 Aug 20; 9(1):12128. PMID: 31431657.
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    3. Hegyi B, Chen-Izu Y, Izu LT, Bányász T. Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and ß-adrenergic stimulation. Can J Physiol Pharmacol. 2019 Aug; 97(8):773-780. PMID: 31091413.
      View in: PubMed
    4. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and ß-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. PMID: 30879336.
      View in: PubMed
    5. Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y. ß-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018 10; 123:168-179. PMID: 30240676.
      View in: PubMed
    6. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 03 16; 8(1):4670. PMID: 29549309.
      View in: PubMed
    7. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. PMID: 29531045.
      View in: PubMed
    8. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and ß-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005852. PMID: 29437761.
      View in: PubMed
    9. Coulibaly Z, Chen-Izu Y, Izu LT. Avoiding phantasms. Cardiovasc Res. 2017 12 01; 113(14):1703-1704. PMID: 29036639.
      View in: PubMed
    10. Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). PMID: 29025768.
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    11. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu LT, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 08; 109:27-37. PMID: 28668303.
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    12. Chen-Izu Y, Izu LT. Mechano-chemo-transduction in cardiac myocytes. J Physiol. 2017 06 15; 595(12):3949-3958. PMID: 28098356.
      View in: PubMed
    13. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. PMID: 27808412.
      View in: PubMed
    14. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu LT. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. PMID: 27653489.
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    15. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. PMID: 27500929.
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    16. Izu LT, Bányász T, Chen-Izu Y. Optimizing Population Variability to Maximize Benefit. PLoS One. 2015; 10(12):e0143475. PMID: 26650247.
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    17. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. PMID: 26643875.
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    18. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu LT, Banyasz T. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):173-6. PMID: 26463508.
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    19. Chen-Izu Y, Izu LT. Measuring the metrics: Correlating t-tubule structure and muscle contraction in the intact heart. J Mol Cell Cardiol. 2015 Aug; 85:153-4. PMID: 26031703.
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    20. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
      View in: PubMed
    21. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289.
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    22. Banyasz T, Szentandrássy N, Magyar J, Szabo Z, Nánási PP, Chen-Izu Y, Izu LT. An emerging antiarrhythmic target: late sodium current. Curr Pharm Des. 2015; 21(8):1073-90. PMID: 25354179.
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    23. Xie Y, Izu LT, Bers DM, Sato D. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys J. 2014 Mar 18; 106(6):1391-7. PMID: 24655514.
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    24. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. PMID: 24643800.
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    25. Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu LT, Chen-Izu Y. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov; 466(11):2067-76. PMID: 24535581.
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    26. Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar; 68:1-11. PMID: 24389341.
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    27. Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014 Feb 14; 114(4):607-15. PMID: 24323672.
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    28. Shaw J, Izu L, Chen-Izu Y. Mechanical analysis of single myocyte contraction in a 3-D elastic matrix. PLoS One. 2013; 8(10):e75492. PMID: 24098388.
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    29. Horvath B, Banyasz T, Jian Z, Hegyi B, Kistamas K, Nanasi PP, Izu LT, Chen-Izu Y. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol. 2013 Nov; 64:59-68. PMID: 24012538.
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    30. Izu LT, Xie Y, Sato D, Bányász T, Chen-Izu Y. Ca²? waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. PMID: 23220129.
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    31. Jonnalagadda D, Izu LT, Whiteheart SW. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood. 2012 Dec 20; 120(26):5209-16. PMID: 23086755.
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    32. Izu LT, Chen-Izu Y. Une cellule type? J Mol Cell Cardiol. 2012 May; 52(5):921-2. PMID: 22326436.
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    33. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes. Heart Rhythm. 2012 Jan; 9(1):134-42. PMID: 21884673.
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    34. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol. 2011 Mar; 50(3):578-81. PMID: 21215755.
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    35. Chen-Izu Y, Izu LT. Cellular cartography. Biophys J. 2010 Dec 15; 99(12):3861-2. PMID: 21156126.
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    36. Satin J, Itzhaki I, Rapoport S, Schroder EA, Izu L, Arbel G, Beyar R, Balke CW, Schiller J, Gepstein L. Calcium handling in human embryonic stem cell-derived cardiomyocytes. Stem Cells. 2008 Aug; 26(8):1961-72. PMID: 18483424.
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    37. Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu LT, Balke CW. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol. 2008 Mar; 93(3):370-82. PMID: 18156167.
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    38. Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, Izu LT, Balke CW. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3301-10. PMID: 17873027.
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    39. Izu LT, Bányász T, Balke CW, Chen-Izu Y. Eavesdropping on the social lives of Ca(2+) sparks. Biophys J. 2007 Nov 15; 93(10):3408-20. PMID: 17675349.
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    40. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. PMID: 17630346.
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    41. Bányász T, Chen-Izu Y, Balke CW, Izu LT. A new approach to the detection and statistical classification of Ca2+ sparks. Biophys J. 2007 Jun 15; 92(12):4458-65. PMID: 17400702.
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    42. Izu LT, Means SA, Shadid JN, Chen-Izu Y, Balke CW. Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J. 2006 Jul 01; 91(1):95-112. PMID: 16603499.
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    43. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu LT. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006 Jul 01; 91(1):1-13. PMID: 16603500.
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    44. Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003 Mar 01; 547(Pt 2):441-51. PMID: 12562899.
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    45. Izu LT, William Balke C. The Ca2+ synapse redo: a matter of location, location, location. Circ Res. 2002 Aug 23; 91(4):276-7. PMID: 12193458.
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    46. Izu LT, McCulle SL, Ferreri-Jacobia MT, Devor DC, Duffey ME. Vasoactive intestinal peptide-stimulated Cl- secretion: activation of cAMP-dependent K+ channels. J Membr Biol. 2002 Apr 01; 186(3):145-57. PMID: 12148841.
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    47. Izu LT, Mauban JR, Balke CW, Wier WG. Large currents generate cardiac Ca2+ sparks. Biophys J. 2001 Jan; 80(1):88-102. PMID: 11159385.
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    48. Izu LT, Wier WG, Balke CW. Evolution of cardiac calcium waves from stochastic calcium sparks. Biophys J. 2001 Jan; 80(1):103-20. PMID: 11159386.
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    49. Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J. 2000 Nov; 79(5):2547-56. PMID: 11053129.
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    50. Izu LT, Wier WG, Balke CW. Theoretical analysis of the Ca2+ spark amplitude distribution. Biophys J. 1998 Sep; 75(3):1144-62. PMID: 9726917.
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    51. Shorofsky SR, Izu L, Wier WG, Balke CW. Ca2+ sparks triggered by patch depolarization in rat heart cells. Circ Res. 1998 Mar 09; 82(4):424-9. PMID: 9506702.
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    52. Li M, Vemulapalli R, Ullah A, Izu L, Duffey ME, Lance P. Downregulation of a human colonic sialyltransferase by a secondary bile acid and a phorbol ester. Am J Physiol. 1998 03; 274(3):G599-606. PMID: 9530163.
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    53. Izu L, Li M, DeMuro R, Duffey ME. G proteins activate ionic conductances at multiple sites in T84 cells. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1222-31. PMID: 9142847.
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    54. Izu LT, Spangler RA. A class of parametrically excited calcium oscillation detectors. Biophys J. 1995 Apr; 68(4):1621-9. PMID: 7787048.
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    55. Kim WK, Johnson RG, Izu LT, Rabin RA. Chronic ethanol exposure inhibits ATP-stimulated but not KCl-stimulated dopamine release in PC 12 cells. J Pharmacol Exp Ther. 1994 Jul; 270(1):336-41. PMID: 8035329.
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    56. Dennison D, Frauenheim KA, Izu L. The DINE microcomputer program: an innovative curricular approach. Health Educ. 1983 Mar-Apr; 14(2):44-7. PMID: 6443908.
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    57. Montaldo PL, Loddo M, Multineddu R, Petrini L, Fois M, Pisano MR, Satta L, Lixi M, Leo P, Isu L. [Evolution of systolic time intervals after prolonged opotherapy in hypothyroid patients]. Boll Soc Ital Cardiol. 1981; 26(4):345-52. PMID: 7340868.
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