Martin Privalsky

Title(s)Distinguished Professor, Microbiology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harrus D, Déméné H, Vasquez E, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A. Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential. Thyroid. 2018 Dec; 28(12):1708-1722. PMID: 30235988.
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    2. Jimenez R, Privalsky ML. A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor. Mol Cell Endocrinol. 2017 05 15; 447:87-97. PMID: 28257829.
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    3. Privalsky ML, Snyder CA, Goodson ML. Corepressor diversification by alternative mRNA splicing is species specific. BMC Evol Biol. 2016 10 19; 16(1):221. PMID: 27756201.
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    4. Snyder CA, Goodson ML, Schroeder AC, Privalsky ML. Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling. Mol Cell Endocrinol. 2015 Sep 15; 413:228-35. PMID: 26166430; PMCID: PMC4556269.
    5. Goodson ML, Young BM, Snyder CA, Schroeder AC, Privalsky ML. Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance. Mol Cell Biol. 2014 Nov 15; 34(22):4104-14. PMID: 25182530; PMCID: PMC4248719.
    6. Schroeder AC, Privalsky ML. Thyroid hormones, t3 and t4, in the brain. Front Endocrinol (Lausanne). 2014; 5:40. PMID: 24744751; PMCID: PMC3978256.
    7. Schroeder A, Jimenez R, Young B, Privalsky ML. The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors. Mol Endocrinol. 2014 May; 28(5):745-57. PMID: 24673558; PMCID: PMC4004778.
    8. Hahm JB, Schroeder AC, Privalsky ML. The two major isoforms of thyroid hormone receptor, TRa1 and TRß1, preferentially partner with distinct panels of auxiliary proteins. Mol Cell Endocrinol. 2014 Mar 05; 383(1-2):80-95. PMID: 24325866.
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    9. Hahm JB, Privalsky ML. Research resource: identification of novel coregulators specific for thyroid hormone receptor-ß2. Mol Endocrinol. 2013 May; 27(5):840-59. PMID: 23558175; PMCID: PMC3634115.
    10. Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest. 2012 Jul; 122(7):2428-38. PMID: 22684107; PMCID: PMC3386813.
    11. Mengeling BJ, Goodson ML, Bourguet W, Privalsky ML. SMRTe, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors a and ß. Mol Cell Endocrinol. 2012 Apr 04; 351(2):306-16. PMID: 22266197; PMCID: PMC3288673.
    12. Goodson ML, Mengeling BJ, Jonas BA, Privalsky ML. Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem. 2011 Dec 30; 286(52):44988-99. PMID: 22065574; PMCID: PMC3247966.
    13. Zhu XG, Kim DW, Goodson ML, Privalsky ML, Cheng SY. NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol. 2011 Jun; 46(3):233-44. PMID: 21389087.
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    14. Rosen MD, Privalsky ML. Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res. 2011; 2011:361304. PMID: 21760978.
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    15. Lee S, Young BM, Wan W, Chan IH, Privalsky ML. A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol. 2011 Jul; 25(7):1111-25. PMID: 21622532; PMCID: PMC3125096.
    16. Rosen MD, Chan IH, Privalsky ML. Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas. Mol Endocrinol. 2011 Aug; 25(8):1311-25. PMID: 21622534; PMCID: PMC3146248.
    17. Mengeling BJ, Phan TQ, Goodson ML, Privalsky ML. Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants. J Biol Chem. 2011 Feb 11; 286(6):4236-47. PMID: 21131350; PMCID: PMC3039402.
    18. Varlakhanova N, Hahm JB, Privalsky ML. Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Mol Cell Endocrinol. 2011 Jan 30; 332(1-2):180-8. PMID: 20965228; PMCID: PMC3011023.
    19. Hsia EY, Goodson ML, Zou JX, Privalsky ML, Chen HW. Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev. 2010 Oct 30; 62(13):1227-37. PMID: 20933027; PMCID: PMC5004779.
    20. Varlakhanova N, Snyder C, Jose S, Hahm JB, Privalsky ML. Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain. Mol Cell Biol. 2010 Mar; 30(6):1434-45. PMID: 20065040; PMCID: PMC2832498.
    21. Chan IH, Privalsky ML. A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation. Mol Cancer Res. 2010 Jan; 8(1):15-23. PMID: 20053725; PMCID: PMC2808454.
    22. Phan TQ, Jow MM, Privalsky ML. DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified. Mol Cell Endocrinol. 2010 May 05; 319(1-2):88-98. PMID: 19945505; PMCID: PMC3270409.
    23. Chan IH, Privalsky ML. Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1. Mol Endocrinol. 2009 Nov; 23(11):1758-75. PMID: 19628582; PMCID: PMC2775939.
    24. Privalsky ML, Lee S, Hahm JB, Young BM, Fong RN, Chan IH. The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors. J Biol Chem. 2009 Jul 17; 284(29):19554-63. PMID: 19487700; PMCID: PMC2740581.
    25. Rosen MD, Privalsky ML. Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity. Mol Endocrinol. 2009 Aug; 23(8):1183-92. PMID: 19407221; PMCID: PMC2718749.
    26. Goodson ML, Farboud B, Privalsky ML. High throughput analysis of nuclear receptor-cofactor interactions. Methods Mol Biol. 2009; 505:157-69. PMID: 19117144.
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    27. Chan IH, Borowsky AD, Privalsky ML. A cautionary note as to the use of pBi-L and related luciferase/transgenic vectors in the study of thyroid endocrinology. Thyroid. 2008 Jun; 18(6):665-6. PMID: 18578620; PMCID: PMC2962860.
    28. Mengeling BJ, Lee S, Privalsky ML. Coactivator recruitment is enhanced by thyroid hormone receptor trimers. Mol Cell Endocrinol. 2008 Jan 02; 280(1-2):47-62. PMID: 18006144; PMCID: PMC2197157.
    29. Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky ML. Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol. 2007 Aug; 21(8):1924-39. PMID: 17519355; PMCID: PMC2675559.
    30. Goodson ML, Farboud B, Privalsky ML. An improved high throughput protein-protein interaction assay for nuclear hormone receptors. Nucl Recept Signal. 2007 Mar 09; 5:e002. PMID: 17464356; PMCID: PMC1853068.
    31. Lee S, Privalsky ML. Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene. 2005 Oct 13; 24(45):6737-52. PMID: 16007162; PMCID: PMC2706103.
    32. McKenzie GJ, Stevenson P, Ward G, Papadia S, Bading H, Chawla S, Privalsky M, Hardingham GE. Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. J Neurochem. 2005 Apr; 93(1):171-85. PMID: 15773917.
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    33. Wan W, Farboud B, Privalsky ML. Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol. 2005 Jun; 19(6):1529-42. PMID: 15802373.
      View in: PubMed
    34. Lee S, Privalsky ML. Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol. 2005 Apr; 19(4):863-78. PMID: 15650024; PMCID: PMC2675561.
    35. Goodson ML, Jonas BA, Privalsky ML. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem. 2005 Mar 04; 280(9):7493-503. PMID: 15632172; PMCID: PMC2720035.
    36. Harper R, Xu C, Di P, Chen Y, Privalsky M, Wu R. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):199-204. PMID: 15465002.
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    37. Jonas BA, Privalsky ML. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem. 2004 Dec 24; 279(52):54676-86. PMID: 15491994; PMCID: PMC2653424.
    38. Mengeling BJ, Pan F, Privalsky ML. Novel mode of deoxyribonucleic acid recognition by thyroid hormone receptors: thyroid hormone receptor beta-isoforms can bind as trimers to natural response elements comprised of reiterated half-sites. Mol Endocrinol. 2005 Jan; 19(1):35-51. PMID: 15459250.
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    39. Farboud B, Privalsky ML. Retinoic acid receptor-alpha is stabilized in a repressive state by its C-terminal, isotype-specific F domain. Mol Endocrinol. 2004 Dec; 18(12):2839-53. PMID: 15331758.
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    40. Hayakawa F, Privalsky ML. Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Cancer Cell. 2004 Apr; 5(4):389-401. PMID: 15093545.
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    41. Privalsky ML. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu Rev Physiol. 2004; 66:315-60. PMID: 14977406.
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    42. Privalsky ML. Activation incarnate. Dev Cell. 2003 Jul; 5(1):1-2. PMID: 12852843.
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    43. Farboud B, Hauksdottir H, Wu Y, Privalsky ML. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol. 2003 Apr; 23(8):2844-58. PMID: 12665583; PMCID: PMC152560.
    44. Hauksdottir H, Farboud B, Privalsky ML. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol Endocrinol. 2003 Mar; 17(3):373-85. PMID: 12554770.
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    45. Ruse MD, Privalsky ML, Sladek FM. Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Mol Cell Biol. 2002 Mar; 22(6):1626-38. PMID: 11865043; PMCID: PMC135595.
    46. Yoh SM, Privalsky ML. Molecular analysis of human resistance to thyroid hormone syndrome. Methods Mol Biol. 2002; 202:129-52. PMID: 12094601.
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    47. Yoh SM, Privalsky ML. Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor. Mol Cell Endocrinol. 2000 Jan 25; 159(1-2):109-24. PMID: 10687857.
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    48. Privalsky ML. Depudecin makes a debut. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3335-7. PMID: 9520362; PMCID: PMC33845.