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Martin L Privalsky

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jimenez R, Privalsky M. A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor. Mol Cell Endocrinol. 2017 May 15; 447:87-97. PMID: 28257829.
      View in: PubMed
    2. Privalsky M, Snyder CA, Goodson ML. Corepressor diversification by alternative mRNA splicing is species specific. BMC Evol Biol. 2016 10 19; 16(1):221. PMID: 27756201.
      View in: PubMed
    3. Snyder CA, Goodson ML, Schroeder AC, Privalsky M. Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling. Mol Cell Endocrinol. 2015 Sep 15; 413:228-35. PMID: 26166430; PMCID: PMC4556269.
    4. Goodson ML, Young BM, Snyder CA, Schroeder AC, Privalsky M. Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance. Mol Cell Biol. 2014 Nov 15; 34(22):4104-14. PMID: 25182530; PMCID: PMC4248719.
    5. Schroeder AC, Privalsky M. Thyroid hormones, t3 and t4, in the brain. Front Endocrinol (Lausanne). 2014; 5:40. PMID: 24744751; PMCID: PMC3978256.
    6. Schroeder A, Jimenez R, Young B, Privalsky M. The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors. Mol Endocrinol. 2014 May; 28(5):745-57. PMID: 24673558; PMCID: PMC4004778.
    7. Hahm JB, Schroeder AC, Privalsky M. The two major isoforms of thyroid hormone receptor, TRa1 and TRß1, preferentially partner with distinct panels of auxiliary proteins. Mol Cell Endocrinol. 2014 Mar 05; 383(1-2):80-95. PMID: 24325866.
      View in: PubMed
    8. Zota AR, Linderholm L, Park JS, Petreas M, Guo T, Privalsky M, Zoeller RT, Woodruff TJ. Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California. Environ Sci Technol. 2013 Oct 15; 47(20):11776-84. PMID: 24066858; PMCID: PMC4086273.
    9. Hahm JB, Privalsky M. Research resource: identification of novel coregulators specific for thyroid hormone receptor-ß2. Mol Endocrinol. 2013 May; 27(5):840-59. PMID: 23558175; PMCID: PMC3634115.
    10. Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky M, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest. 2012 Jul; 122(7):2428-38. PMID: 22684107; PMCID: PMC3386813.
    11. Mengeling BJ, Goodson ML, Bourguet W, Privalsky M. SMRTe, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors a and ß. Mol Cell Endocrinol. 2012 Apr 04; 351(2):306-16. PMID: 22266197; PMCID: PMC3288673.
    12. Goodson ML, Mengeling BJ, Jonas BA, Privalsky M. Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation. J Biol Chem. 2011 Dec 30; 286(52):44988-99. PMID: 22065574; PMCID: PMC3247966.
    13. Zhu XG, Kim DW, Goodson ML, Privalsky M, Cheng SY. NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. J Mol Endocrinol. 2011 Jun; 46(3):233-44. PMID: 21389087.
      View in: PubMed
    14. Rosen MD, Privalsky M. Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res. 2011; 2011:361304. PMID: 21760978; PMCID: PMC3134260.
    15. Lee S, Young BM, Wan W, Chan IH, Privalsky M. A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Mol Endocrinol. 2011 Jul; 25(7):1111-25. PMID: 21622532; PMCID: PMC3125096.
    16. Rosen MD, Chan IH, Privalsky M. Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas. Mol Endocrinol. 2011 Aug; 25(8):1311-25. PMID: 21622534; PMCID: PMC3146248.
    17. Mengeling BJ, Phan TQ, Goodson ML, Privalsky M. Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants. J Biol Chem. 2011 Feb 11; 286(6):4236-47. PMID: 21131350; PMCID: PMC3039402.
    18. Varlakhanova N, Hahm JB, Privalsky M. Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Mol Cell Endocrinol. 2011 Jan 30; 332(1-2):180-8. PMID: 20965228; PMCID: PMC3011023.
    19. Hsia EY, Goodson ML, Zou JX, Privalsky M, Chen HW. Nuclear receptor coregulators as a new paradigm for therapeutic targeting. Adv Drug Deliv Rev. 2010 Oct 30; 62(13):1227-37. PMID: 20933027; PMCID: PMC5004779.
    20. Varlakhanova N, Snyder C, Jose S, Hahm JB, Privalsky M. Estrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain. Mol Cell Biol. 2010 Mar; 30(6):1434-45. PMID: 20065040; PMCID: PMC2832498.
    21. Chan IH, Privalsky M. A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation. Mol Cancer Res. 2010 Jan; 8(1):15-23. PMID: 20053725; PMCID: PMC2808454.
    22. Phan TQ, Jow MM, Privalsky M. DNA recognition by thyroid hormone and retinoic acid receptors: 3,4,5 rule modified. Mol Cell Endocrinol. 2010 May 05; 319(1-2):88-98. PMID: 19945505; PMCID: PMC3270409.
    23. Chan IH, Privalsky M. Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1. Mol Endocrinol. 2009 Nov; 23(11):1758-75. PMID: 19628582; PMCID: PMC2775939.
    24. Privalsky M, Lee S, Hahm JB, Young BM, Fong RN, Chan IH. The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors. J Biol Chem. 2009 Jul 17; 284(29):19554-63. PMID: 19487700; PMCID: PMC2740581.
    25. Rosen MD, Privalsky M. Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity. Mol Endocrinol. 2009 Aug; 23(8):1183-92. PMID: 19407221; PMCID: PMC2718749.
    26. Goodson ML, Farboud B, Privalsky M. High throughput analysis of nuclear receptor-cofactor interactions. Methods Mol Biol. 2009; 505:157-69. PMID: 19117144.
      View in: PubMed
    27. Chan IH, Borowsky AD, Privalsky M. A cautionary note as to the use of pBi-L and related luciferase/transgenic vectors in the study of thyroid endocrinology. Thyroid. 2008 Jun; 18(6):665-6. PMID: 18578620; PMCID: PMC2962860.
    28. Mengeling BJ, Lee S, Privalsky M. Coactivator recruitment is enhanced by thyroid hormone receptor trimers. Mol Cell Endocrinol. 2008 Jan 02; 280(1-2):47-62. PMID: 18006144; PMCID: PMC2197157.
    29. Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky M. Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. Mol Endocrinol. 2007 Aug; 21(8):1924-39. PMID: 17519355; PMCID: PMC2675559.
    30. Goodson ML, Farboud B, Privalsky M. An improved high throughput protein-protein interaction assay for nuclear hormone receptors. Nucl Recept Signal. 2007 Mar 09; 5:e002. PMID: 17464356; PMCID: PMC1853068.
    31. Lee S, Privalsky M. Multiple mutations contribute to repression by the v-Erb A oncoprotein. Oncogene. 2005 Oct 13; 24(45):6737-52. PMID: 16007162; PMCID: PMC2706103.
    32. McKenzie GJ, Stevenson P, Ward G, Papadia S, Bading H, Chawla S, Privalsky M, Hardingham GE. Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. J Neurochem. 2005 Apr; 93(1):171-85. PMID: 15773917.
      View in: PubMed
    33. Wan W, Farboud B, Privalsky M. Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants that selectively impair beta2 isoform function. Mol Endocrinol. 2005 Jun; 19(6):1529-42. PMID: 15802373.
      View in: PubMed
    34. Lee S, Privalsky M. Heterodimers of retinoic acid receptors and thyroid hormone receptors display unique combinatorial regulatory properties. Mol Endocrinol. 2005 Apr; 19(4):863-78. PMID: 15650024; PMCID: PMC2675561.
    35. Goodson ML, Jonas BA, Privalsky M. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem. 2005 Mar 04; 280(9):7493-503. PMID: 15632172; PMCID: PMC2720035.
    36. Harper R, Xu C, Di P, Chen Y, Privalsky M, Wu R. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):199-204. PMID: 15465002.
      View in: PubMed
    37. Jonas BA, Privalsky M. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J Biol Chem. 2004 Dec 24; 279(52):54676-86. PMID: 15491994; PMCID: PMC2653424.
    38. Mengeling BJ, Pan F, Privalsky M. Novel mode of deoxyribonucleic acid recognition by thyroid hormone receptors: thyroid hormone receptor beta-isoforms can bind as trimers to natural response elements comprised of reiterated half-sites. Mol Endocrinol. 2005 Jan; 19(1):35-51. PMID: 15459250.
      View in: PubMed
    39. Farboud B, Privalsky M. Retinoic acid receptor-alpha is stabilized in a repressive state by its C-terminal, isotype-specific F domain. Mol Endocrinol. 2004 Dec; 18(12):2839-53. PMID: 15331758.
      View in: PubMed
    40. Hayakawa F, Privalsky M. Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. Cancer Cell. 2004 Apr; 5(4):389-401. PMID: 15093545.
      View in: PubMed
    41. Hayakawa F, Towatari M, Ozawa Y, Tomita A, Privalsky M, Saito H. Functional regulation of GATA-2 by acetylation. J Leukoc Biol. 2004 Mar; 75(3):529-40. PMID: 15001660.
      View in: PubMed
    42. Privalsky M. The role of corepressors in transcriptional regulation by nuclear hormone receptors. Annu Rev Physiol. 2004; 66:315-60. PMID: 14977406.
      View in: PubMed
    43. Privalsky M. Activation incarnate. Dev Cell. 2003 Jul; 5(1):1-2. PMID: 12852843.
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    44. Farboud B, Hauksdottir H, Wu Y, Privalsky M. Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression. Mol Cell Biol. 2003 Apr; 23(8):2844-58. PMID: 12665583; PMCID: PMC152560.
    45. Hauksdottir H, Farboud B, Privalsky M. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. Mol Endocrinol. 2003 Mar; 17(3):373-85. PMID: 12554770.
      View in: PubMed
    46. Ruse MD, Privalsky M, Sladek FM. Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain. Mol Cell Biol. 2002 Mar; 22(6):1626-38. PMID: 11865043; PMCID: PMC135595.
    47. Yoh SM, Privalsky M. Molecular analysis of human resistance to thyroid hormone syndrome. Methods Mol Biol. 2002; 202:129-52. PMID: 12094601.
      View in: PubMed