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Michael A Savageau

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lomnitz JG, Savageau M. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems. Sci Rep. 2016 08 31; 6:32375. PMID: 27578053.
      View in: PubMed
    2. Lomnitz JG, Savageau M. Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Front Genet. 2016; 7:118. PMID: 27462346; PMCID: PMC4940394.
    3. Lomnitz JG, Savageau M. Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire. NPJ Syst Biol Appl. 2015; 1. PMID: 26998346.
      View in: PubMed
    4. Fasani RA, Savageau M. Unrelated toxin-antitoxin systems cooperate to induce persistence. J R Soc Interface. 2015 Jul 06; 12(108):20150130. PMID: 26063817; PMCID: PMC4528579.
    5. Tolla DA, Kiley PJ, Lomnitz JG, Savageau M. Design principles of a conditional futile cycle exploited for regulation. Mol Biosyst. 2015 Jul; 11(7):1841-9. PMID: 25851148; PMCID: PMC4470783.
    6. Fasani RA, Savageau M. Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. Mol Biol Evol. 2014 Nov; 31(11):2865-78. PMID: 25118252; PMCID: PMC4209129.
    7. Lomnitz JG, Savageau M. Strategy revealing phenotypic differences among synthetic oscillator designs. ACS Synth Biol. 2014 Sep 19; 3(9):686-701. PMID: 25019938; PMCID: PMC4210169.
    8. Moura A, Savageau M, Alves R. Relative amino acid composition signatures of organisms and environments. PLoS One. 2013; 8(10):e77319. PMID: 24204807; PMCID: PMC3808408.
    9. Fasani RA, Savageau M. Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):E2528-37. PMID: 23781105; PMCID: PMC3703989.
    10. Lomnitz JG, Savageau M. Phenotypic deconstruction of gene circuitry. Chaos. 2013 Jun; 23(2):025108. PMID: 23822506; PMCID: PMC3695976.
    11. Williams K, Savageau M, Blumenthal RM. A bistable hysteretic switch in an activator-repressor regulated restriction-modification system. Nucleic Acids Res. 2013 Jul; 41(12):6045-57. PMID: 23630319; PMCID: PMC3695507.
    12. Martínez-Antonio A, Lomnitz JG, Sandoval S, Aldana M, Savageau M. Regulatory design governing progression of population growth phases in bacteria. PLoS One. 2012; 7(2):e30654. PMID: 22363461; PMCID: PMC3283595.
    13. Savageau M. Design of the lac gene circuit revisited. Math Biosci. 2011 May; 231(1):19-38. PMID: 21414326; PMCID: PMC3126112.
    14. Savageau M. Biomedical engineering strategies in system design space. Ann Biomed Eng. 2011 Apr; 39(4):1278-95. PMID: 21203848; PMCID: PMC3074507.
    15. Tolla DA, Savageau M. Phenotypic repertoire of the FNR regulatory network in Escherichia coli. Mol Microbiol. 2011 Jan; 79(1):149-65. PMID: 21166900; PMCID: PMC3075585.
    16. Coelho PM, Salvador A, Savageau M. Relating mutant genotype to phenotype via quantitative behavior of the NADPH redox cycle in human erythrocytes. PLoS One. 2010 Sep 28; 5(9). PMID: 20927393; PMCID: PMC2946920.
    17. Fasani RA, Savageau M. Automated construction and analysis of the design space for biochemical systems. Bioinformatics. 2010 Oct 15; 26(20):2601-9. PMID: 20823298; PMCID: PMC3025649.
    18. Tolla DA, Savageau M. Regulation of aerobic-to-anaerobic transitions by the FNR cycle in Escherichia coli. J Mol Biol. 2010 Apr 09; 397(4):893-905. PMID: 20156450; PMCID: PMC2867928.
    19. Reams AB, Kofoid E, Savageau M, Roth JR. Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination. Genetics. 2010 Apr; 184(4):1077-94. PMID: 20083614; PMCID: PMC2865909.
    20. Savageau M, Fasani RA. Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett. 2009 Dec 17; 583(24):3914-22. PMID: 19879266; PMCID: PMC2888490.
    21. Coelho PM, Salvador A, Savageau M. Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles. PLoS Comput Biol. 2009 Mar; 5(3):e1000319. PMID: 19300483; PMCID: PMC2650413.
    22. Savageau M, Coelho PM, Fasani RA, Tolla DA, Salvador A. Phenotypes and tolerances in the design space of biochemical systems. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6435-40. PMID: 19279208; PMCID: PMC2672487.
    23. Igoshin OA, Alves R, Savageau M. Hysteretic and graded responses in bacterial two-component signal transduction. Mol Microbiol. 2008 Jun; 68(5):1196-215. PMID: 18363790; PMCID: PMC4372536.
    24. Igoshin OA, Brody MS, Price CW, Savageau M. Distinctive topologies of partner-switching signaling networks correlate with their physiological roles. J Mol Biol. 2007 Jun 22; 369(5):1333-52. PMID: 17498739; PMCID: PMC2727513.
    25. Igoshin OA, Price CW, Savageau M. Signalling network with a bistable hysteretic switch controls developmental activation of the sigma transcription factor in Bacillus subtilis. Mol Microbiol. 2006 Jul; 61(1):165-84. PMID: 16824103.
      View in: PubMed
    26. Salvador A, Savageau M. Evolution of enzymes in a series is driven by dissimilar functional demands. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2226-31. PMID: 16461898; PMCID: PMC1413729.
    27. Alves R, Savageau M. Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes. Mol Microbiol. 2005 May; 56(4):1017-34. PMID: 15853887; PMCID: PMC1839009.
    28. Wall ME, Hlavacek WS, Savageau M. Design of gene circuits: lessons from bacteria. Nat Rev Genet. 2004 Jan; 5(1):34-42. PMID: 14708014.
      View in: PubMed
    29. Salvador A, Savageau M. Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14463-8. PMID: 14614139; PMCID: PMC283614.
    30. Wall ME, Hlavacek WS, Savageau M. Design principles for regulator gene expression in a repressible gene circuit. J Mol Biol. 2003 Sep 26; 332(4):861-76. PMID: 12972257.
      View in: PubMed
    31. Atkinson MR, Savageau M, Myers JT, Ninfa AJ. Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli. Cell. 2003 May 30; 113(5):597-607. PMID: 12787501.
      View in: PubMed
    32. Alves R, Savageau M. Comparative analysis of prototype two-component systems with either bifunctional or monofunctional sensors: differences in molecular structure and physiological function. Mol Microbiol. 2003 Apr; 48(1):25-51. PMID: 12657043.
      View in: PubMed
    33. Savageau M. Alternative designs for a genetic switch: analysis of switching times using the piecewise power-law representation. Math Biosci. 2002 Nov-Dec; 180:237-53. PMID: 12387925.
      View in: PubMed
    34. Savageau M. Design principles for elementary gene circuits: Elements, methods, and examples. Chaos. 2001 Mar; 11(1):142-159. PMID: 12779449.
      View in: PubMed
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