Michael S Denison

InstitutionUniversity of California Davis
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    1. Dou L, Poitevin S, Sallée M, Addi T, Gondouin B, McKay N, Denison M, Jourde-Chiche N, Duval-Sabatier A, Cerini C, Brunet P, Dignat-George F, Burtey S. Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease. Kidney Int. 2018 Apr; 93(4):986-999. PMID: 29395338.
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    2. Lam MM, Engwall M, Denison M, Larsson M. Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. Environ Toxicol Chem. 2018 Feb; 37(2):385-397. PMID: 28834568.
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    3. Datta S, He G, Tomilov A, Sahdeo S, Denison M, Cortopassi G. In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride. Environ Health Perspect. 2017 08 22; 125(8):087015. PMID: 28885978.
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    4. Neale PA, Altenburger R, Aït-Aïssa S, Brion F, Busch W, de Aragão Umbuzeiro G, Denison M, Du Pasquier D, Hilscherová K, Hollert H, Morales DA, Novák J, Schlichting R, Seiler TB, Serra H, Shao Y, Tindall AJ, Tollefsen KE, Williams TD, Escher BI. Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water. Water Res. 2017 10 15; 123:734-750. PMID: 28728110.
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    5. Malisch R, Denison M, Fiedler H, Fürst P, Hoogenboom RLAP, Schaechtele A, Schrenk D, van den Berg M. Do PCDD/PCDF standard solutions used in dioxin analysis pose a risk as potentially acutely toxic to lab personnel? Chemosphere. 2017 Oct; 185:489-498. PMID: 28715759.
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    6. Corrada D, Denison M, Bonati L. Structural modeling of the AhR:ARNT complex in the bHLH-PASA-PASB region elucidates the key determinants of dimerization. Mol Biosyst. 2017 May 02; 13(5):981-990. PMID: 28393157.
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    7. Anderson CG, Joshi G, Bair DA, Oriol C, He G, Parikh SJ, Denison M, Scow KM. Use of nuclear receptor luciferase-based bioassays to detect endocrine active chemicals in a biosolids-biochar amended soil. Chemosphere. 2017 Aug; 181:160-167. PMID: 28437741.
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    8. Elshenawy OH, Abdelhamid G, Soshilov AA, Denison M, El-Kadi AO. Down-regulation of cytochrome P450 1A1 by monomethylarsonous acid in human HepG2 cells. Toxicol Lett. 2017 Mar 15; 270:34-50. PMID: 28189647.
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    9. Denison M, Faber SC. And Now for Something Completely Different: Diversity in Ligand-Dependent Activation of Ah Receptor Responses. Curr Opin Toxicol. 2017 Feb; 2:124-131. PMID: 28845473.
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    10. Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison M, Soshilov A, Weaver E, Safe S. Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. Toxicol Sci. 2017 02; 155(2):458-473. PMID: 27837168.
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    11. Joshi G, Schmidt R, Scow KM, Denison M, Hristova KR. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology. 2016 09; 162(9):1563-1571. PMID: 27450417.
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    12. Corrada D, Soshilov AA, Denison M, Bonati L. Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation. PLoS Comput Biol. 2016 06; 12(6):e1004981. PMID: 27295348.
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    13. Croes K, Van den Heuvel R, Van den Bril B, Staelens J, Denison M, Van Langenhove K, Vandermarken T, Elskens M. Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. Environ Res. 2016 10; 150:66-72. PMID: 27257826.
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    14. Bak SM, Iida M, Soshilov AA, Denison M, Iwata H, Kim EY. Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 and AHR2 in the red seabream (Pagrus major). Arch Toxicol. 2017 Jan; 91(1):301-312. PMID: 27188387.
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    15. Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, Denison M, Fangue NA, Connon RE. Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls. Arch Environ Contam Toxicol. 2016 Aug; 71(2):210-23. PMID: 27155869.
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    16. Brennan JC, Bassal A, He G, Denison M. Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor a and ß for improved detection of estrogenic/antiestrogenic chemicals. Environ Toxicol Chem. 2016 Jan; 35(1):91-100. PMID: 26139245; PMCID: PMC4772679 [Available on 01/01/17].
    17. Khedidji S, Croes K, Yassaa N, Ladji R, Denison M, Baeyens W, Elskens M. Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay. Environ Sci Pollut Res Int. 2017 May; 24(13):11868-11877. PMID: 26611627.
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    18. Neale PA, Ait-Aissa S, Brack W, Creusot N, Denison M, Deutschmann B, Hilscherová K, Hollert H, Krauss M, Novák J, Schulze T, Seiler TB, Serra H, Shao Y, Escher BI. Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling. Environ Sci Technol. 2015 Dec 15; 49(24):14614-24. PMID: 26516785.
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    19. Caron-Beaudoin É, Denison M, Sanderson JT. Effects of Neonicotinoids on Promoter-Specific Expression and Activity of Aromatase (CYP19) in Human Adrenocortical Carcinoma (H295R) and Primary Umbilical Vein Endothelial (HUVEC) Cells. Toxicol Sci. 2016 Jan; 149(1):134-44. PMID: 26464060.
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    20. Brennan JC, He G, Tsutsumi T, Zhao J, Wirth E, Fulton MH, Denison M. Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection Limits. Environ Sci Technol. 2015 Oct 06; 49(19):11903-12. PMID: 26366531; PMCID: PMC4772899 [Available on 10/06/16].
    21. Croes K, Debaillie P, Van den Bril B, Staelens J, Vandermarken T, Van Langenhove K, Denison M, Leermakers M, Elskens M. Assessment of estrogenic activity in PM10 air samples with the ERE-CALUX bioassay: Method optimization and implementation at an urban location in Flanders (Belgium). Chemosphere. 2016 Feb; 144:392-8. PMID: 26383266.
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    22. Peng C, Muthusamy S, Xia Q, Lal V, Denison M, Ng JC. Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells. Mutagenesis. 2015 Sep; 30(5):593-602. PMID: 26085548.
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    23. DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison M. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol. 2015 Jun 15; 28(6):1176-85. PMID: 26001051; PMCID: PMC4469569.
    24. Shoots J, Fraccalvieri D, Franks DG, Denison M, Hahn ME, Bonati L, Powell WH. An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Environ Sci Technol. 2015 Jun 02; 49(11):6993-7001. PMID: 25941739; PMCID: PMC4454367.
    25. Joshi G, Schmidt R, Scow KM, Denison M, Hristova KR. Gene mdpC plays a regulatory role in the methyl-tert-butyl ether degradation pathway of Methylibium petroleiphilum strain PM1. FEMS Microbiol Lett. 2015 Apr; 362(7). PMID: 25724531; PMCID: PMC4459789.
    26. Mexia N, Gaitanis G, Velegraki A, Soshilov A, Denison M, Magiatis P. Pityriazepin and other potent AhR ligands isolated from Malassezia furfur yeast. Arch Biochem Biophys. 2015 Apr 01; 571:16-20. PMID: 25721496; PMCID: PMC4454357.
    27. Maayah ZH, Ghebeh H, Alhaider AA, El-Kadi AO, Soshilov AA, Denison M, Ansari MA, Korashy HM. Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway. Toxicol Appl Pharmacol. 2015 Apr 15; 284(2):217-26. PMID: 25697376.
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    28. Bittner GD, Denison M, Yang CZ, Stoner MA, He G. Chemicals having estrogenic activity can be released from some bisphenol A-free, hard and clear, thermoplastic resins. Environ Health. 2014 Dec 04; 13:103. PMID: 25477047; PMCID: PMC4298073.
    29. Frauenstein K, Tigges J, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison M, Vogel CF, Haarmann-Stemmann T. Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol. 2015 Aug; 89(8):1329-36. PMID: 25082669; PMCID: PMC4454626.
    30. Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison M, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. 2014 Jul 10; 511(7508):184-90. PMID: 24930766; PMCID: PMC4098076.
    31. Novotna A, Korhonova M, Bartonkova I, Soshilov AA, Denison M, Bogdanova K, Kolar M, Bednar P, Dvorak Z. Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor. PLoS One. 2014; 9(7):e101832. PMID: 25000292; PMCID: PMC4084896.
    32. Ghorbanzadeh M, van Ede KI, Larsson M, van Duursen MB, Poellinger L, Lücke-Johansson S, Machala M, Pencíková K, Vondrácek J, van den Berg M, Denison M, Ringsted T, Andersson PL. In vitro and in silico derived relative effect potencies of ah-receptor-mediated effects by PCDD/Fs and PCBs in rat, mouse, and guinea pig CALUX cell lines. Chem Res Toxicol. 2014 Jul 21; 27(7):1120-32. PMID: 24901989.
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    33. Soshilov AA, Denison M. Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis. Mol Cell Biol. 2014 May; 34(9):1707-19. PMID: 24591650; PMCID: PMC3993610.
    34. Addeck A, Croes K, Van Langenhove K, Denison M, Afify AS, Gao Y, Elskens M, Baeyens W. Time-integrated monitoring of dioxin-like polychlorinated biphenyls (dl-PCBs) in aquatic environments using the ceramic toximeter and the CALUX bioassay. Talanta. 2014 Mar; 120:413-8. PMID: 24468390; PMCID: PMC4379351.
    35. Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison M. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-?B. J Biol Chem. 2014 Jan 17; 289(3):1866-75. PMID: 24302727; PMCID: PMC3894361.
    36. DeGroot DE, Hayashi A, Denison M. Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. Arch Biochem Biophys. 2014 Jan 01; 541:13-20. PMID: 24200861; PMCID: PMC3875388.
    37. Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison M, Chris Le X, Klotz LO, El-Kadi AO. Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 2014 Feb; 67:171-87. PMID: 24161444.
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    38. DeGroot DE, Denison M. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure. Toxicol Sci. 2014 Jan; 137(1):102-13. PMID: 24136190; PMCID: PMC3924043.
    39. Brander SM, Connon RE, He G, Hobbs JA, Smalling KL, Teh SJ, White JW, Werner I, Denison M, Cherr GN. From 'omics to otoliths: responses of an estuarine fish to endocrine disrupting compounds across biological scales. PLoS One. 2013; 8(9):e74251. PMID: 24086325; PMCID: PMC3783432.
    40. Addeck A, Croes K, Van Langenhove K, Denison M, Elhamalawy A, Elskens M, Baeyens W. Time-integrated monitoring of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in urban and industrial wastewaters using a ceramic toximeter and the CALUX bioassay. Chemosphere. 2014 Jan; 94:27-35. PMID: 24075528; PMCID: PMC4308619.
    41. Brennan JC, Denison M, Holstege DM, Magiatis P, Dallas JL, Gutierrez EG, Soshilov AA, Millam JR. 2,3-cis-2R,3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complement Altern Med. 2013 Jun 14; 13:133. PMID: 23768005; PMCID: PMC3695784.
    42. Hu Q, He G, Zhao J, Soshilov A, Denison M, Zhang A, Yin H, Fraccalvieri D, Bonati L, Xie Q, Zhao B. Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS One. 2013; 8(6):e66258. PMID: 23776647; PMCID: PMC3679084.
    43. Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison M, Zapletalova M, Anzenbacher P, Dvorak Z. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett. 2013 Jul 31; 221(1):1-8. PMID: 23735880; PMCID: PMC3759295.
    44. van den Berg M, Denison M, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE. Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. Toxicol Sci. 2013 Jun; 133(2):197-208. PMID: 23492812; PMCID: PMC3663561.
    45. Magiatis P, Pappas P, Gaitanis G, Mexia N, Melliou E, Galanou M, Vlachos C, Stathopoulou K, Skaltsounis AL, Marselos M, Velegraki A, Denison M, Bassukas ID. Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. J Invest Dermatol. 2013 Aug; 133(8):2023-30. PMID: 23448877; PMCID: PMC3714356.
    46. Odio C, Holzman SA, Denison M, Fraccalvieri D, Bonati L, Franks DG, Hahn ME, Powell WH. Specific ligand binding domain residues confer low dioxin responsiveness to AHR1ß of Xenopus laevis. Biochemistry. 2013 Mar 12; 52(10):1746-54. PMID: 23394719; PMCID: PMC3669666.
    47. Zhao B, Bohonowych JE, Timme-Laragy A, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison M. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One. 2013; 8(2):e56860. PMID: 23441220; PMCID: PMC3575475.
    48. Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison M, Anzenbacher P, Dvorak Z. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett. 2013 Apr 26; 218(3):253-9. PMID: 23419638; PMCID: PMC3644221.
    49. Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison M. Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry. 2013 Jan 29; 52(4):714-25. PMID: 23286227; PMCID: PMC3568667.
    50. Brander SM, He G, Smalling KL, Denison M, Cherr GN. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec; 31(12):2848-55. PMID: 23007834; PMCID: PMC3529915.
    51. Wall RJ, He G, Denison M, Congiu C, Onnis V, Fernandes A, Bell DR, Rose M, Rowlands JC, Balboni G, Mellor IR. Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. Toxicology. 2012 Jul 16; 297(1-3):26-33. PMID: 22507882; PMCID: PMC3515069.
    52. Tiong CT, Chen C, Zhang SJ, Li J, Soshilov A, Denison M, Lee LS, Tam VH, Wong SP, Xu HE, Yong EL. A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERa protein. Carcinogenesis. 2012 May; 33(5):1089-97. PMID: 22345291; PMCID: PMC3334513.
    53. Motto I, Bordogna A, Soshilov AA, Denison M, Bonati L. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011 Nov 28; 51(11):2868-81. PMID: 21981577; PMCID: PMC3263330.
    54. El Gendy MA, Soshilov AA, Denison M, El-Kadi AO. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol. 2012 Feb; 50(2):353-62. PMID: 22037238; PMCID: PMC3281145.
    55. Addeck A, Croes K, Van Langenhove K, Denison M, Elskens M, Baeyens W. Dioxin analysis in water by using a passive sampler and CALUX bioassay. Talanta. 2012 Jan 15; 88:73-8. PMID: 22265472.
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    56. El Gendy MA, Soshilov AA, Denison M, El-Kadi AO. Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. Toxicol Lett. 2012 Jan 05; 208(1):51-61. PMID: 22001777; PMCID: PMC3263333.
    57. Denison M, Soshilov AA, He G, DeGroot DE, Zhao B. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci. 2011 Nov; 124(1):1-22. PMID: 21908767; PMCID: PMC3196658.
    58. Soshilov A, Denison M. Ligand displaces heat shock protein 90 from overlapping binding sites within the aryl hydrocarbon receptor ligand-binding domain. J Biol Chem. 2011 Oct 07; 286(40):35275-82. PMID: 21856752; PMCID: PMC3186366.
    59. Korashy HM, Anwar-Mohamed A, Soshilov AA, Denison M, El-Kadi AO. The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation. Chem Res Toxicol. 2011 Sep 19; 24(9):1540-8. PMID: 21732638; PMCID: PMC3263331.
    60. He G, Tsutsumi T, Zhao B, Baston DS, Zhao J, Heath-Pagliuso S, Denison M. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci. 2011 Oct; 123(2):511-22. PMID: 21775728; PMCID: PMC3179681.
    61. Van Langenhove K, Croes K, Denison M, Elskens M, Baeyens W. The CALUX bio-assay: analytical comparison between mouse hepatoma cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin response elements. Talanta. 2011 Sep 30; 85(4):2039-46. PMID: 21872055.
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    62. He G, Zhao B, Denison M. Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environ Toxicol Chem. 2011 Aug; 30(8):1915-25. PMID: 21590714; PMCID: PMC3263332.
    63. Aung HH, Lame MW, Gohil K, He G, Denison M, Rutledge JC, Wilson DW. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol Genomics. 2011 Aug 16; 43(15):917-29. PMID: 21652769; PMCID: PMC4631546.
    64. Baston DS, Denison M. Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta. 2011 Feb 15; 83(5):1415-21. PMID: 21238730; PMCID: PMC3036574.
    65. Lee YC, Oslund KL, Thai P, Velichko S, Fujisawa T, Duong T, Denison M, Wu R. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):270-6. PMID: 20971882; PMCID: PMC3175556.
    66. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison M, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10; 329(5997):1345-8. PMID: 20688981; PMCID: PMC3033342.
    67. Zhao B, Degroot DE, Hayashi A, He G, Denison M. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci. 2010 Oct; 117(2):393-403. PMID: 20634293; PMCID: PMC2940411.
    68. Zhao B, Baston DS, Khan E, Sorrentino C, Denison M. Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci China Chem. 2010 May; 53(5):1010-1016. PMID: 21394221.
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    69. Kennedy K, Macova M, Bartkow ME, Hawker DW, Zhao B, Denison M, Mueller JF. Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmos Pollut Res. 2010 Jan 01; 1(1):50-58. PMID: 21552507.
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    70. Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison M, Pessah IN, Hammock BD. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect. 2009 Dec; 117(12):1867-72. PMID: 20049205; PMCID: PMC2799460.
    71. Pandini A, Soshilov AA, Song Y, Zhao J, Bonati L, Denison M. Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis. Biochemistry. 2009 Jun 30; 48(25):5972-83. PMID: 19456125; PMCID: PMC2859071.
    72. Kanematsu M, Hayashi A, Denison M, Young TM. Characterization and potential environmental risks of leachate from shredded rubber mulches. Chemosphere. 2009 Aug; 76(7):952-8. PMID: 19450864; PMCID: PMC2735888.
    73. Kennedy K, Macova M, Leusch F, Bartkow ME, Hawker DW, Zhao B, Denison M, Mueller JF. Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity. Anal Bioanal Chem. 2009 Jul; 394(5):1413-21. PMID: 19430962; PMCID: PMC2864012.
    74. Jaikanlaya C, Settachan D, Denison M, Ruchirawat M, van den Berg M. PCBs contamination in seafood species at the Eastern Coast of Thailand. Chemosphere. 2009 Jun; 76(2):239-49. PMID: 19375780; PMCID: PMC2855220.
    75. Palumbo AJ, Denison M, Doroshov SI, Tjeerdema RS. Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus). Environ Toxicol Chem. 2009 Aug; 28(8):1749-55. PMID: 19292566; PMCID: PMC2858920.
    76. Rochester JR, Klasing KC, Stevenson L, Denison M, Berry W, Millam JR. Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks. Reprod Toxicol. 2009 Jan; 27(1):63-71. PMID: 19103282; PMCID: PMC2858001.
    77. La Merrill M, Baston DS, Denison M, Birnbaum LS, Pomp D, Threadgill DW. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E203-10. PMID: 18840765; PMCID: PMC2636987.
    78. Soshilov A, Denison M. Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem. 2008 Nov 21; 283(47):32995-3005. PMID: 18806268; PMCID: PMC2583286.
    79. Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison M, Lasley B, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect. 2008 Sep; 116(9):1203-10. PMID: 18795164; PMCID: PMC2535623.
    80. Lawrence BP, Denison M, Novak H, Vorderstrasse BA, Harrer N, Neruda W, Reichel C, Woisetschläger M. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15; 112(4):1158-65. PMID: 18270326; PMCID: PMC2515129.
    81. Bohonowych JE, Zhao B, Timme-Laragy A, Jung D, Di Giulio RT, Denison M. Newspapers and newspaper ink contain agonists for the ah receptor. Toxicol Sci. 2008 Apr; 102(2):278-90. PMID: 18203687; PMCID: PMC2855230.
    82. Cahill TM, Groskova D, Charles MJ, Sanborn JR, Denison M, Baker L. Atmospheric concentrations of polybrominated diphenyl ethers at near-source sites. Environ Sci Technol. 2007 Sep 15; 41(18):6370-7. PMID: 17948781.
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    83. Brown DJ, Orelien J, Gordon JD, Chu AC, Chu MD, Nakamura M, Handa H, Kayama F, Denison M, Clark GC. Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data. Environ Sci Technol. 2007 Jun 15; 41(12):4354-60. PMID: 17626436; PMCID: PMC2877589.
    84. Nording M, Denison M, Baston D, Persson Y, Spinnel E, Haglund P. Analysis of dioxins in contaminated soils with the calux and caflux bioassays, an immunoassay, and gas chromatography/high-resolution mass spectrometry. Environ Toxicol Chem. 2007 Jun; 26(6):1122-9. PMID: 17571676; PMCID: PMC2858913.
    85. Bohonowych JE, Denison M. Persistent binding of ligands to the aryl hydrocarbon receptor. Toxicol Sci. 2007 Jul; 98(1):99-109. PMID: 17431010; PMCID: PMC2857992.
    86. Hu W, Sorrentino C, Denison M, Kolaja K, Fielden MR. Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun; 71(6):1475-86. PMID: 17327465.
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    87. Pandini A, Denison M, Song Y, Soshilov AA, Bonati L. Structural and functional characterization of the aryl hydrocarbon receptor ligand binding domain by homology modeling and mutational analysis. Biochemistry. 2007 Jan 23; 46(3):696-708. PMID: 17223691; PMCID: PMC2860805.
    88. Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci. 2006 Oct; 93(2):223-41. PMID: 16829543.
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    89. Klein GP, Hodge EM, Diamond ML, Yip A, Dann T, Stern G, Denison M, Harper PA. Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity in vitro. Environ Health Perspect. 2006 May; 114(5):697-703. PMID: 16675423; PMCID: PMC1459922.
    90. Zhao B, Baston DS, Hammock B, Denison M. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol. 2006; 20(3):103-13. PMID: 16788953; PMCID: PMC3032054.
    91. Windal I, Denison M, Birnbaum LS, Van Wouwe N, Baeyens W, Goeyens L. Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. Environ Sci Technol. 2005 Oct 01; 39(19):7357-64. PMID: 16245802.
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    92. Jeong SH, Cho JH, Park JM, Denison M. Rapid bioassay for the determination of dioxins and dioxin-like PCDFs and PCBs in meat and animal feeds. J Anal Toxicol. 2005 Apr; 29(3):156-62. PMID: 15842757.
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    93. Sanderson JT, Hordijk J, Denison M, Springsteel MF, Nantz MH, van den Berg M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov; 82(1):70-9. PMID: 15319488.
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    94. Denison M, Zhao B, Baston DS, Clark GC, Murata H, Han D. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta. 2004 Aug 08; 63(5):1123-33. PMID: 18969542.
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    95. Brown DJ, Van Overmeire I, Goeyens L, Denison M, De Vito MJ, Clark GC. Analysis of Ah receptor pathway activation by brominated flame retardants. Chemosphere. 2004 Jun; 55(11):1509-18. PMID: 15099731.
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    96. Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene. 2004 May 27; 23(25):4400-12. PMID: 15077192.
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    97. Han D, Nagy SR, Denison M. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors. 2004; 20(1):11-22. PMID: 15096657.
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    98. Monk SA, Denison M, Rice RH. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys. 2003 Nov 15; 419(2):158-69. PMID: 14592459.
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    99. Jeuken A, Keser BJ, Khan E, Brouwer A, Koeman J, Denison M. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. J Agric Food Chem. 2003 Aug 27; 51(18):5478-87. PMID: 12926901.
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    100. Arrieta DE, Ontiveros CC, Li WW, Garcia JH, Denison M, McDonald JD, Burchiel SW, Washburn BS. Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border. Environ Health Perspect. 2003 Aug; 111(10):1299-305. PMID: 12896850; PMCID: PMC1241610.
    101. Lashley MR, Niedzinski EJ, Rogers JM, Denison M, Nantz MH. Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. Bioorg Med Chem. 2002 Dec; 10(12):4075-82. PMID: 12413861.
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    102. Ziccardi MH, Gardner IA, Mazet JA, Denison M. Application of the luciferase cell culture bioassay for the detection of refined petroleum products. Mar Pollut Bull. 2002 Oct; 44(10):983-91. PMID: 12474956.
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    103. Han D, Denison M, Tachibana H, Yamada K. Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes. Biol Pharm Bull. 2002 Oct; 25(10):1263-7. PMID: 12392075.
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    104. Ziccardi MH, Gardner IA, Denison M. Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons. Environ Toxicol Chem. 2002 Oct; 21(10):2027-33. PMID: 12371477.
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    105. Denison M, Pandini A, Nagy SR, Baldwin EP, Bonati L. Ligand binding and activation of the Ah receptor. Chem Biol Interact. 2002 Sep 20; 141(1-2):3-24. PMID: 12213382.
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    106. Nagy SR, Denison M. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun. 2002 Aug 30; 296(4):799-805. PMID: 12200118.
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    107. Natarajan K, Overstreet JW, Rogers JM, Denison M, Chen J, Lohstroh PN, McConnell DS, Lasley BL. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environ Health Perspect. 2002 Aug; 110(8):791-5. PMID: 12153760; PMCID: PMC1240950.
    108. Rushing SR, Denison M. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch Biochem Biophys. 2002 Jul 15; 403(2):189-201. PMID: 12139968.
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    109. Ziccardi MH, Mazet JA, Gardner IA, Boyce WM, Denison M. Validation of a cell culture bioassay for detection of petroleum exposure in mink (Mustela vison) as a model for detection in sea otters (Enhydra lutris). Am J Vet Res. 2002 Jul; 63(7):963-8. PMID: 12118676.
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    110. Han DH, Denison M, Tachibana H, Yamada K. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul; 66(7):1479-87. PMID: 12224631.
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    111. Rogers JM, Denison M. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol Pharmacol. 2002 Jun; 61(6):1393-403. PMID: 12021401.
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    112. Denison M, Rogers JM, Rushing SR, Jones CL, Tetangco SC, Heath-Pagliuso S. Analysis of the aryl hydrocarbon receptor (AhR) signal transduction pathway. Curr Protoc Toxicol. 2002 May; Chapter 4:Unit4.8. PMID: 20945300.
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    113. Nagy SR, Sanborn JR, Hammock BD, Denison M. Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists. Toxicol Sci. 2002 Feb; 65(2):200-10. PMID: 11812924.
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    114. Nagy SR, Liu G, Lam KS, Denison M. Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry. 2002 Jan 22; 41(3):861-8. PMID: 11790108.
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    115. Denison M, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol. 2003; 43:309-34. PMID: 12540743.
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    116. Liu PC, Moreno-Aliaga MJ, Dunlap DY, Hu XM, Denison M, Matsumura F. Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells. J Biochem Mol Toxicol. 2002; 16(2):70-83. PMID: 11979424.
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