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Natalie J Torok

Title(s)Professor, INTERNAL MEDICINE
SchoolUniversity of California, Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mikami K, Endo T, Sawada N, Igarashi G, Kimura M, Hasegawa T, Iino C, Tomita H, Sawada K, Nakaji S, Matsuzaka M, Torok NJ, Fukuda S. Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population. Cytokine. 2020 Feb; 126:154927. PMID: 31756645.
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    2. Zhao P, Han SN, Arumugam S, Yousaf MN, Qin Y, Jiang JX, Torok NJ, Chen Y, Mankash MS, Liu J, Li J, Iwakiri Y, Ouyang X. Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 01; 317(4):G387-G397. PMID: 31411894.
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    3. Torok NJ. Macrophage Nourishment in Nonalcoholic Steatohepatitis: A Novel Role for Ketone Bodies. Hepatology. 2019 Nov; 70(5):1856-1858. PMID: 31107977.
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    4. Torok NJ. P300, A New Player in Mechanosensitivity and Activation of Cancer-Associated Fibroblasts. Gastroenterology. 2018 06; 154(8):2025-2026. PMID: 29733834.
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    5. Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, LePine Pongratz R, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1a Transactivation in Steatohepatitis. Cell Metab. 2018 May 01; 27(5):1156. PMID: 29719229.
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    6. Tepper CG, Dang JHT, Stewart SL, Fang DM, Wong KA, Liu SY, Davis RR, Dao DY, Gregg JP, Török NJ, Chen MS. High frequency of the PNPLA3 rs738409 [G] single-nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease. Cancer. 2018 04 01; 124 Suppl 7:1583-1589. PMID: 29578593.
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    7. Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1a Transactivation in Steatohepatitis. Cell Metab. 2018 02 06; 27(2):339-350.e3. PMID: 29414684.
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    8. Zhou Z, Xu MJ, Cai Y, Wang W, Jiang JX, Varga ZV, Feng D, Pacher P, Kunos G, Torok NJ, Gao B. Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):399-413. PMID: 29552626.
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    9. Matsumoto M, Zhang J, Zhang X, Liu J, Jiang JX, Yamaguchi K, Taruno A, Katsuyama M, Iwata K, Ibi M, Cui W, Matsuno K, Marunaka Y, Itoh Y, Torok NJ, Yabe-Nishimura C. The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free Radic Biol Med. 2018 02 01; 115:412-420. PMID: 29274380.
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    10. Sasaki Y, Dehnad A, Fish S, Sato A, Jiang J, Tian J, Schröder K, Brandes R, Török NJ. NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease. Sci Rep. 2017 04 06; 7:46144. PMID: 28383062.
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    11. Haque A, Gheibi P, Stybayeva G, Gao Y, Torok N, Revzin A. Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury. Sci Rep. 2016 10 31; 6:36077. PMID: 27796316.
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    12. Tian J, Yang G, Chen HY, Hsu DK, Tomilov A, Olson KA, Dehnad A, Fish SR, Cortopassi G, Zhao B, Liu FT, Gershwin ME, Török NJ, Jiang JX. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016 12; 30(12):4202-4213. PMID: 27630169.
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    13. Torok NJ. Dysregulation of redox pathways in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G667-G674. PMID: 27562057.
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    14. Marsano JG, Torok NJ. Metabolic Syndrome Post-Liver Transplant: Can We Predict? Metab Syndr Relat Disord. 2016 08; 14(6):289-90. PMID: 27304753.
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    15. Török NJ. Extracellular vesicles and ceramide: new mediators for macrophage chemotaxis? J Lipid Res. 2016 Feb; 57(2):157-8. PMID: 26729816.
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    16. Torok NJ. Update on Alcoholic Hepatitis. Biomolecules. 2015 Nov 02; 5(4):2978-86. PMID: 26540078.
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    17. Torok NJ. Vascular adhesion protein 1 in nonalcoholic steatohepatitis: a novel biomarker? Hepatology. 2015 Oct; 62(4):1313-5. PMID: 26084585.
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    18. Akhtar E, Parikh DA, Torok NJ. Calciphylaxis in a Patient With Alcoholic Cirrhosis. ACG Case Rep J. 2015 Jul; 2(4):209-10. PMID: 26203440.
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    19. Serizawa N, Tian J, Fukada H, Baghy K, Scott F, Chen X, Kiss Z, Olson K, Hsu D, Liu FT, Török NJ, Zhao B, Jiang JX. Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation. Lab Invest. 2015 Oct; 95(10):1145-56. PMID: 26146960.
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    20. Asmuth DM, Pinchuk IV, Wu J, Vargas G, Chen X, Mann S, Albanese A, Ma ZM, Saroufeem R, Melcher GP, Troia-Cancio P, Torok NJ, Miller CJ, Powell DW. Role of intestinal myofibroblasts in HIV-associated intestinal collagen deposition and immune reconstitution following combination antiretroviral therapy. AIDS. 2015 May 15; 29(8):877-88. PMID: 25784439.
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    21. Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015 Aug; 149(2):468-80.e10. PMID: 25888330.
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    22. Torok NJ, Dranoff JA, Schuppan D, Friedman SL. Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014. Hepatology. 2015 Aug; 62(2):627-34. PMID: 25626988.
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    23. Jiang JX, Török NJ. MLK3 as a regulator of disease progression in Non-alcoholic steatohepatitis. Liver Int. 2014 Sep; 34(8):1131-2. PMID: 24690035.
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    24. McGahan JP, Bishop J, Webb J, Howell L, Torok N, Lamba R, Corwin MT. Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease. Int J Hepatol. 2013; 2013:174103. PMID: 24369506.
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    25. Jiang JX, Chen X, Fukada H, Serizawa N, Devaraj S, Török NJ. Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-a-converting enzyme activity in mice. Hepatology. 2013 Oct; 58(4):1339-48. PMID: 23703665.
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    26. Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, Török NJ, Jiang JX, Havel PJ, Lönnerdal B, Kim K, Halsted CH. Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology. 2013 Feb; 57(2):555-65. PMID: 22945834.
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    27. Jung CJ, Iyengar S, Blahnik KR, Jiang JX, Tahimic C, Torok NJ, de vere White RW, Farnham PJ, Zern M. Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFß tumor suppressor signaling pathways. Mol Cancer Res. 2012 Jul; 10(7):979-91. PMID: 22622027.
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    28. Jiang JX, Chen X, Serizawa N, Szyndralewiez C, Page P, Schröder K, Brandes RP, Devaraj S, Török NJ. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med. 2012 Jul 15; 53(2):289-96. PMID: 22618020.
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    29. Jiang JX, Chen X, Hsu DK, Baghy K, Serizawa N, Scott F, Takada Y, Takada Y, Fukada H, Chen J, Devaraj S, Adamson R, Liu FT, Török NJ. Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 15; 302(4):G439-46. PMID: 22159281.
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    30. Ellis CL, Ma ZM, Mann SK, Li CS, Wu J, Knight TH, Yotter T, Hayes TL, Maniar AH, Troia-Cancio PV, Overman HA, Torok NJ, Albanese A, Rutledge JC, Miller CJ, Pollard RB, Asmuth DM. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr. 2011 Aug 15; 57(5):363-70. PMID: 21436711.
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    31. Cui W, Matsuno K, Iwata K, Ibi M, Matsumoto M, Zhang J, Zhu K, Katsuyama M, Torok NJ, Yabe-Nishimura C. NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology. 2011 Sep 02; 54(3):949-58. PMID: 21618578.
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    32. Devaraj S, Torok N. Leptin: the missing link between obesity and heart disease? Atherosclerosis. 2011 Aug; 217(2):322-3. PMID: 21663911.
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    33. Jiang JX, Venugopal S, Serizawa N, Chen X, Scott F, Li Y, Adamson R, Devaraj S, Shah V, Gershwin ME, Friedman SL, Török NJ. Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology. 2010 Oct; 139(4):1375-84. PMID: 20685364.
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    34. Medici V, Ali MR, Seo S, Aoki CA, Rossaro L, Kim K, Fuller WD, Vidovszky TJ, Smith W, Jiang JX, Maganti K, Havel PJ, Kamboj A, Ramsamooj R, Török NJ. Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease. Obesity (Silver Spring). 2010 Dec; 18(12):2268-73. PMID: 20448542.
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    35. Selmi C, Torok NJ, Affronti A, Gershwin ME. Genomic variants associated with primary biliary cirrhosis. Genome Med. 2010 Jan 26; 2(1):5. PMID: 20193050.
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    36. Venugopal SK, Jiang J, Kim TH, Li Y, Wang SS, Torok NJ, Wu J, Zern MA. Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G101-6. PMID: 19892940.
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    37. Jiang JX, Mikami K, Venugopal S, Li Y, Török NJ. Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol. 2009 Jul; 51(1):139-48. PMID: 19457567.
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    38. Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology. 2009 Jan; 49(1):185-94. PMID: 18844235.
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    39. Silveira MG, Torok NJ, Gossard AA, Keach JC, Jorgensen RA, Petz JL, Lindor KD. Minocycline in the treatment of patients with primary sclerosing cholangitis: results of a pilot study. Am J Gastroenterol. 2009 Jan; 104(1):83-8. PMID: 19098854.
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    40. Jiang JX, Mikami K, Shah VH, Torok NJ. Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism. Hepatology. 2008 Nov; 48(5):1497-505. PMID: 18925608.
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    41. Török NJ. Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol. 2008; 43(5):315-21. PMID: 18592147.
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    42. Devaraj S, Torok N, Dasu MR, Samols D, Jialal I. Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. Arterioscler Thromb Vasc Biol. 2008 Jul; 28(7):1368-74. PMID: 18451326.
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    43. Jiang J, Torok N. Nonalcoholic steatohepatitis and the metabolic syndrome. Metab Syndr Relat Disord. 2008 Mar; 6(1):1-7. PMID: 18370830.
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    44. Torok NJ. Apoptotic cell death takes its toll. Hepatology. 2007 Nov; 46(5):1323-5. PMID: 17969040.
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    45. Seo S, Maganti K, Khehra M, Ramsamooj R, Tsodikov A, Bowlus C, McVicar J, Zern M, Torok N. De novo nonalcoholic fatty liver disease after liver transplantation. Liver Transpl. 2007 Jun; 13(6):844-7. PMID: 17029282.
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    46. Zhan SS, Jiang JX, Wu J, Halsted C, Friedman SL, Zern MA, Torok NJ. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology. 2006 Mar; 43(3):435-43. PMID: 16496318.
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    47. Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores GJ. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab Invest. 2003 May; 83(5):655-63. PMID: 12746475.
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    48. Török NJ, Higuchi H, Bronk S, Gores GJ. Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9. Cancer Res. 2002 Mar 15; 62(6):1648-53. PMID: 11912135.
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    49. Török NJ, Larusso EM, McNiven MA. Alterations in vesicle transport and cell polarity in rat hepatocytes subjected to mechanical or chemical cholestasis. Gastroenterology. 2001 Nov; 121(5):1176-84. PMID: 11677210.
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    50. Torok N, Gores GJ. Cholangiocarcinoma. Semin Gastrointest Dis. 2001 Apr; 12(2):125-32. PMID: 11352119.
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    51. Yoon Y, Török N, Krueger E, Oswald B, McNiven MA. Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes. Am J Physiol. 1998 04; 274(4):G757-66. PMID: 9575859.
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    52. Török N, Marks D, Hsiao K, Oswald BJ, McNiven MA. Vesicle movement in rat hepatocytes is reduced by ethanol exposure: alterations in microtubule-based motor enzymes. Gastroenterology. 1997 Dec; 113(6):1938-48. PMID: 9394734.
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    53. Török N, Urrutia R, Nakamura T, McNiven MA. Upregulation of molecular motor-encoding genes during hepatocyte growth factor- and epidermal growth factor-induced cell motility. J Cell Physiol. 1996 Jun; 167(3):422-33. PMID: 8655596.
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    54. Nagy P, Török N, Ladånyi A, Kopper L. Expression of transforming growth factor-beta 1 in human non-Hodgkin's lymphoma xenografts. J Natl Cancer Inst. 1991 Aug 21; 83(16):1174-5. PMID: 1886149.
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