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Paul J Hagerman

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jiraanont P, Kumar M, Tang HT, Espinal G, Hagerman P, Hagerman RJ, Chutabhakdikul N, Tassone F. Size and methylation mosaicism in males with Fragile X syndrome. Expert Rev Mol Diagn. 2017 Nov; 17(11):1023-1032. PMID: 28929824.
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    2. Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman P. Fragile X syndrome. Nat Rev Dis Primers. 2017 Sep 29; 3:17065. PMID: 28960184.
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    3. Lechpammer M, Martínez Cerdeno V, Hunsaker MR, Hah M, Gonzales H, Tisch S, Joffe R, Pamphlett R, Tassone F, Hagerman P, Bolitho SJ, Hagerman RJ. Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases. Croat Med J. 2017 Aug 31; 58(4):310-315. PMID: 28857524.
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    4. Robin G, López JR, Espinal GM, Hulsizer S, Hagerman P, Pessah IN. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2017 07 15; 26(14):2649-2666. PMID: 28444183.
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    5. Martínez-Cerdeño V, Lechpammer M, Hagerman P, Hagerman R. Two FMR1 premutation cases without nuclear inclusions. Mov Disord. 2017 Sep; 32(9):1328-1329. PMID: 28568317.
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    6. Jiraanont P, Sweha SR, AlOlaby RR, Silva M, Tang HT, Durbin-Johnson B, Schneider A, Espinal GM, Hagerman P, Rivera SM, Hessl D, Hagerman RJ, Chutabhakdikul N, Tassone F. Clinical and molecular correlates in fragile X premutation females. eNeurologicalSci. 2017 Jun; 7:49-56. PMID: 28971146.
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    7. Martínez-Cerdeño V, Lechpammer M, Noctor S, Ariza J, Hagerman P, Hagerman R. FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome. Clin Case Rep. 2017 May; 5(5):625-629. PMID: 28469864.
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    8. Ariza J, Rogers H, Hartvigsen A, Snell M, Dill M, Judd D, Hagerman P, Martínez-Cerdeño V. Iron accumulation and dysregulation in the putamen in fragile X-associated tremor/ataxia syndrome. Mov Disord. 2017 04; 32(4):585-591. PMID: 28233916.
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    9. Ariza J, Rogers H, Monterrubio A, Reyes-Miranda A, Hagerman P, Martínez-Cerdeño V. A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells. Cerebellum. 2016 10; 15(5):546-51. PMID: 27108270.
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    10. Rogers H, Ariza J, Monterrubio A, Hagerman P, Martínez-Cerdeño V. Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS. Cerebellum. 2016 10; 15(5):641-4. PMID: 27259564.
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    11. Hagerman RJ, Hagerman P. Fragile X-associated tremor/ataxia syndrome - features, mechanisms and management. Nat Rev Neurol. 2016 Jul; 12(7):403-12. PMID: 27340021.
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    12. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman P, Hagerman R, Lagna G, Hata A. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. PMID: 27273096.
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    13. Pham TT, Yin J, Eid JS, Adams E, Lam R, Turner SW, Loomis EW, Wang JY, Hagerman P, Hanes JW. Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications. Mol Genet Genomics. 2016 Jun; 291(3):1491-504. PMID: 26825750.
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    14. Hukema RK, Buijsen RA, Schonewille M, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Verhagen RF, van Dessel L, Maas A, Charlet-Berguerand N, De Zeeuw CI, Hagerman P, Berman RF, Willemsen R. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. 2015 Sep 01; 24(17):4948-57. PMID: 26060190; PMCID: PMC4527492.
    15. Hagerman P, Hagerman RJ. Fragile X-associated tremor/ataxia syndrome. Ann N Y Acad Sci. 2015 Mar; 1338:58-70. PMID: 25622649; PMCID: PMC4363162.
    16. Ariza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño V. Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. Brain Res. 2015 Feb 19; 1598:88-96. PMID: 25498860; PMCID: PMC4340768.
    17. Pretto DI, Eid JS, Yrigollen CM, Tang HT, Loomis EW, Raske C, Durbin-Johnson B, Hagerman P, Tassone F. Differential increases of specific FMR1 mRNA isoforms in premutation carriers. J Med Genet. 2015 Jan; 52(1):42-52. PMID: 25358671; PMCID: PMC4394606.
    18. Pretto D, Yrigollen CM, Tang HT, Williamson J, Espinal G, Iwahashi CK, Durbin-Johnson B, Hagerman RJ, Hagerman P, Tassone F. Clinical and molecular implications of mosaicism in FMR1 full mutations. Front Genet. 2014; 5:318. PMID: 25278957; PMCID: PMC4166380.
    19. Yang JC, Chi L, Teichholtz S, Schneider A, Nanakul R, Nowacki R, Seritan A, Reed B, DeCarli C, Iragui VJ, Kutas M, Hagerman P, Hagerman RJ, Olichney JM. ERP abnormalities elicited by word repetition in fragile X-associated tremor/ataxia syndrome (FXTAS) and amnestic MCI. Neuropsychologia. 2014 Oct; 63:34-42. PMID: 25111034; PMCID: PMC4194142.
    20. Tassone F, Hagerman P, Hagerman RJ. Fragile x premutation. J Neurodev Disord. 2014; 6(1):22. PMID: 25170346; PMCID: PMC4147873.
    21. Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. 2014 Jul; 17:116-25. PMID: 25034306; PMCID: PMC4142054.
    22. Yang JC, Niu YQ, Simon C, Seritan AL, Chen L, Schneider A, Moghaddam ST, Hagerman P, Hagerman RJ, Olichney JM. Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): a double-blind brain potential study. Neuropsychopharmacology. 2014 Nov; 39(12):2760-8. PMID: 24871547; PMCID: PMC4200486.
    23. Juang BT, Ludwig AL, Benedetti KL, Gu C, Collins K, Morales C, Asundi A, Wittmann T, L'Etoile N, Hagerman P. Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans. Hum Mol Genet. 2014 Sep 15; 23(18):4945-59. PMID: 24821701; PMCID: PMC4140470.
    24. Loomis EW, Sanz LA, Chédin F, Hagerman P. Transcription-associated R-loop formation across the human FMR1 CGG-repeat region. PLoS Genet. 2014 Apr; 10(4):e1004294. PMID: 24743386; PMCID: PMC3990486.
    25. Seritan AL, Nguyen DV, Mu Y, Tassone F, Bourgeois JA, Schneider A, Cogswell JB, Cook KR, Leehey MA, Grigsby J, Olichney JM, Adams PE, Legg W, Zhang L, Hagerman P, Hagerman RJ. Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2014 Mar; 75(3):264-71. PMID: 24345444; PMCID: PMC4296896.
    26. Ludwig AL, Espinal GM, Pretto DI, Jamal AL, Arque G, Tassone F, Berman RF, Hagerman P. CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size. Hum Mol Genet. 2014 Jun 15; 23(12):3228-38. PMID: 24463622; PMCID: PMC4030777.
    27. Hukema RK, Buijsen RA, Raske C, Severijnen LA, Nieuwenhuizen-Bakker I, Minneboo M, Maas A, de Crom R, Kros JM, Hagerman P, Berman RF, Willemsen R. Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo. Cell Cycle. 2014; 13(16):2600-8. PMID: 25486200; PMCID: PMC4614669.
    28. Yang JC, Simon C, Schneider A, Seritan AL, Hamilton L, Hagerman P, Hagerman RJ, Olichney JM. Abnormal semantic processing in females with fragile X-associated tremor/ataxia syndrome. Genes Brain Behav. 2014 Feb; 13(2):152-62. PMID: 24299169; PMCID: PMC3905835.
    29. Yang JC, Simon C, Niu YQ, Bogost M, Schneider A, Tassone F, Seritan A, Grigsby J, Hagerman P, Hagerman RJ, Olichney JM. Phenotypes of hypofrontality in older female fragile X premutation carriers. Ann Neurol. 2013 Aug; 74(2):275-83. PMID: 23686745; PMCID: PMC3906211.
    30. Hagerman R, Hagerman P. Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurol. 2013 Aug; 12(8):786-98. PMID: 23867198; PMCID: PMC3922535.
    31. Hagerman P. Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms. Acta Neuropathol. 2013 Jul; 126(1):1-19. PMID: 23793382; PMCID: PMC3904666.
    32. Pretto DI, Hunsaker MR, Cunningham CL, Greco CM, Hagerman RJ, Noctor SC, Hall DA, Hagerman P, Tassone F. Intranuclear inclusions in a fragile X mosaic male. Transl Neurodegener. 2013 May 21; 2(1):10. PMID: 23692864; PMCID: PMC3668897.
    33. Cao Z, Hulsizer S, Cui Y, Pretto DL, Kim KH, Hagerman P, Tassone F, Pessah IN. Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem. 2013 May 10; 288(19):13831-41. PMID: 23553633; PMCID: PMC3650419.
    34. Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman P, Todd PK, Charlet-Berguerand N. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Rep. 2013 Mar 28; 3(3):869-80. PMID: 23478018; PMCID: PMC3639429.
    35. Wang JM, Koldewyn K, Hashimoto R, Schneider A, Le L, Tassone F, Cheung K, Hagerman P, Hessl D, Rivera SM. Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding. Front Hum Neurosci. 2012; 6:297. PMID: 23115550; PMCID: PMC3483622.
    36. Wang JY, Hessl D, Iwahashi C, Cheung K, Schneider A, Hagerman RJ, Hagerman P, Rivera SM. Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles. Neuroimage. 2013 Jan 15; 65:288-98. PMID: 23063447; PMCID: PMC3540208.
    37. Loomis EW, Eid JS, Peluso P, Yin J, Hickey L, Rank D, McCalmon S, Hagerman RJ, Tassone F, Hagerman P. Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene. Genome Res. 2013 Jan; 23(1):121-8. PMID: 23064752; PMCID: PMC3530672.
    38. Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman P, Pessah IN. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. J Neurochem. 2012 Nov; 123(4):613-21. PMID: 22924671; PMCID: PMC3564636.
    39. Yang JC, Chan SH, Khan S, Schneider A, Nanakul R, Teichholtz S, Niu YQ, Seritan A, Tassone F, Grigsby J, Hagerman P, Hagerman RJ, Olichney JM. Neural substrates of executive dysfunction in fragile X-associated tremor/ataxia syndrome (FXTAS): a brain potential study. Cereb Cortex. 2013 Nov; 23(11):2657-66. PMID: 22918986; PMCID: PMC3792740.
    40. Winarni TI, Chonchaiya W, Sumekar TA, Ashwood P, Morales GM, Tassone F, Nguyen DV, Faradz SM, Van de Water J, Cook K, Hamlin A, Mu Y, Hagerman P, Hagerman RJ. Immune-mediated disorders among women carriers of fragile X premutation alleles. Am J Med Genet A. 2012 Oct; 158A(10):2473-81. PMID: 22903889; PMCID: PMC4105154.
    41. Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman P. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet. 2012 Sep 01; 21(17):3795-805. PMID: 22641815; PMCID: PMC3412379.
    42. Hagerman P. Current Gaps in Understanding the Molecular Basis of FXTAS. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23440729; PMCID: PMC3379894.
    43. Yrigollen CM, Durbin-Johnson B, Gane L, Nelson DL, Hagerman R, Hagerman P, Tassone F. AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome. Genet Med. 2012 Aug; 14(8):729-36. PMID: 22498846; PMCID: PMC3990283.
    44. Jenkins EC, Tassone F, Ye L, Hoogeveen AT, Brown WT, Hagerman RJ, Hagerman P. Reduced telomere length in individuals with FMR1 premutations and full mutations. Am J Med Genet A. 2012 May; 158A(5):1060-5. PMID: 22489017; PMCID: PMC3402180.
    45. Tassone F, Greco CM, Hunsaker MR, Seritan AL, Berman RF, Gane LW, Jacquemont S, Basuta K, Jin LW, Hagerman P, Hagerman RJ. Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS. Genes Brain Behav. 2012 Jul; 11(5):577-85. PMID: 22463693; PMCID: PMC3965773.
    46. Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman P, Pessah IN. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Hum Mol Genet. 2012 Jul 01; 21(13):2923-35. PMID: 22466801; PMCID: PMC3373240.
    47. Leehey MA, Hagerman P. Fragile X-associated tremor/ataxia syndrome. Handb Clin Neurol. 2012; 103:373-86. PMID: 21827901.
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    48. Selmeczy D, Koldewyn K, Wang JM, Lee A, Harvey D, Hessl DR, Tassone F, Adams P, Hagerman RJ, Hagerman P, Rivera SM. Investigation of amygdala volume in men with the fragile X premutation. Brain Imaging Behav. 2011 Dec; 5(4):285-94. PMID: 21786216; PMCID: PMC3982607.
    49. Stöger R, Genereux DP, Hagerman RJ, Hagerman P, Tassone F, Laird CD. Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome. PLoS One. 2011; 6(8):e23648. PMID: 21909353; PMCID: PMC3166088.
    50. Hessl D, Wang JM, Schneider A, Koldewyn K, Le L, Iwahashi C, Cheung K, Tassone F, Hagerman P, Rivera SM. Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation. Biol Psychiatry. 2011 Nov 01; 70(9):859-65. PMID: 21783174; PMCID: PMC3191264.
    51. Hunsaker MR, Greco CM, Spath MA, Smits AP, Navarro CS, Tassone F, Kros JM, Severijnen LA, Berry-Kravis EM, Berman RF, Hagerman P, Willemsen R, Hagerman RJ, Hukema RK. Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathol. 2011 Oct; 122(4):467-79. PMID: 21785977; PMCID: PMC3222079.
    52. Chen L, Hadd A, Sah S, Houghton JF, Filipovic-Sadic S, Zhang W, Hagerman P, Tassone F, Latham GJ. High-resolution methylation polymerase chain reaction for fragile X analysis: evidence for novel FMR1 methylation patterns undetected in Southern blot analyses. Genet Med. 2011 Jun; 13(6):528-538. PMID: 21430544; PMCID: PMC4043840.
    53. Hunsaker MR, Greco CM, Tassone F, Berman RF, Willemsen R, Hagerman RJ, Hagerman P. Rare intranuclear inclusions in the brains of 3 older adult males with fragile x syndrome: implications for the spectrum of fragile x-associated disorders. J Neuropathol Exp Neurol. 2011 Jun; 70(6):462-9. PMID: 21572337; PMCID: PMC3109086.
    54. Hagerman R, Au J, Hagerman P. FMR1 premutation and full mutation molecular mechanisms related to autism. J Neurodev Disord. 2011 Sep; 3(3):211-24. PMID: 21617890; PMCID: PMC3261276.
    55. Hall DA, Berry-Kravis E, Zhang W, Tassone F, Spector E, Zerbe G, Hagerman P, Ouyang B, Leehey MA. FMR1 gray-zone alleles: association with Parkinson's disease in women? Mov Disord. 2011 Aug 15; 26(10):1900-6. PMID: 21567456; PMCID: PMC3934001.
    56. Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C, Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman P, Giulivi C. Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug 01; 20(15):3079-92. PMID: 21558427; PMCID: PMC3131047.
    57. Narcisa V, Aguilar D, Nguyen DV, Campos L, Brodovsky J, White S, Adams P, Tassone F, Hagerman P, Hagerman RJ. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS. Curr Gerontol Geriatr Res. 2011; 2011:484713. PMID: 23008705; PMCID: PMC3114433.
    58. Tassone F, De Rubeis S, Carosi C, La Fata G, Serpa G, Raske C, Willemsen R, Hagerman P, Bagni C. Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles. Nucleic Acids Res. 2011 Aug; 39(14):6172-85. PMID: 21478165; PMCID: PMC3152321.
    59. Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE, Hagerman P. CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Hum Mol Genet. 2011 Jun 01; 20(11):2161-70. PMID: 21389081; PMCID: PMC3090194.
    60. Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman P, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism. 2011 Feb 08; 2(1):2. PMID: 21303513; PMCID: PMC3045897.
    61. Ludwig AL, Hershey JW, Hagerman P. Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning. J Mol Biol. 2011 Mar 18; 407(1):21-34. PMID: 21237174; PMCID: PMC3046292.
    62. Cunningham CL, Martínez Cerdeño V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman P, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Hum Mol Genet. 2011 Jan 01; 20(1):64-79. PMID: 20935171; PMCID: PMC3000676.
    63. Hagerman R, Hoem G, Hagerman P. Fragile X and autism: Intertwined at the molecular level leading to targeted treatments. Mol Autism. 2010 Sep 21; 1(1):12. PMID: 20858229; PMCID: PMC2954865.
    64. Ross-Inta C, Omanska-Klusek A, Wong S, Barrow C, Garcia-Arocena D, Iwahashi C, Berry-Kravis E, Hagerman RJ, Hagerman P, Giulivi C. Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome. Biochem J. 2010 Aug 01; 429(3):545-52. PMID: 20513237; PMCID: PMC4011071.
    65. Chen L, Hadd A, Sah S, Filipovic-Sadic S, Krosting J, Sekinger E, Pan R, Hagerman P, Stenzel TT, Tassone F, Latham GJ. An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis. J Mol Diagn. 2010 Sep; 12(5):589-600. PMID: 20616364; PMCID: PMC2928422.
    66. Paul R, Pessah IN, Gane L, Ono M, Hagerman P, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology. 2010 Aug; 31(4):399-402. PMID: 20466021; PMCID: PMC3918243.
    67. Garcia-Arocena D, Hagerman P. Advances in understanding the molecular basis of FXTAS. Hum Mol Genet. 2010 Apr 15; 19(R1):R83-9. PMID: 20430935; PMCID: PMC2875053.
    68. Adams PE, Adams JS, Nguyen DV, Hessl D, Brunberg JA, Tassone F, Zhang W, Koldewyn K, Rivera SM, Grigsby J, Zhang L, Decarli C, Hagerman P, Hagerman RJ. Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 05; 153B(3):775-85. PMID: 19908235; PMCID: PMC2868927.
    69. Sellier C, Rau F, Liu Y, Tassone F, Hukema RK, Gattoni R, Schneider A, Richard S, Willemsen R, Elliott DJ, Hagerman P, Charlet-Berguerand N. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J. 2010 Apr 07; 29(7):1248-61. PMID: 20186122; PMCID: PMC2857464.
    70. Filipovic-Sadic S, Sah S, Chen L, Krosting J, Sekinger E, Zhang W, Hagerman P, Stenzel TT, Hadd AG, Latham GJ, Tassone F. A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome. Clin Chem. 2010 Mar; 56(3):399-408. PMID: 20056738; PMCID: PMC4031651.
    71. Chen Y, Tassone F, Berman RF, Hagerman P, Hagerman RJ, Willemsen R, Pessah IN. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet. 2010 Jan 01; 19(1):196-208. PMID: 19846466; PMCID: PMC2792156.
    72. Raske C, Hagerman P. Molecular pathogenesis of fragile X-associated tremor/ataxia syndrome. J Investig Med. 2009 Dec; 57(8):825-9. PMID: 19794313; PMCID: PMC2787679.
    73. Garcia-Arocena D, Yang JE, Brouwer JR, Tassone F, Iwahashi C, Berry-Kravis EM, Goetz CG, Sumis AM, Zhou L, Nguyen DV, Campos L, Howell E, Ludwig A, Greco C, Willemsen R, Hagerman RJ, Hagerman P. Fibroblast phenotype in male carriers of FMR1 premutation alleles. Hum Mol Genet. 2010 Jan 15; 19(2):299-312. PMID: 19864489; PMCID: PMC2796892.
    74. Brega AG, Reynolds A, Bennett RE, Leehey MA, Bounds LS, Cogswell JB, Hagerman RJ, Hagerman P, Grigsby J. Functional status of men with the fragile X premutation, with and without the tremor/ataxia syndrome (FXTAS). Int J Geriatr Psychiatry. 2009 Oct; 24(10):1101-9. PMID: 19404994; PMCID: PMC4414034.
    75. Ludwig AL, Raske C, Tassone F, Garcia-Arocena D, Hershey JW, Hagerman P. Translation of the FMR1 mRNA is not influenced by AGG interruptions. Nucleic Acids Res. 2009 Nov; 37(20):6896-904. PMID: 19752155; PMCID: PMC2777427.
    76. Hagerman P, Stafstrom CE. Origins of epilepsy in fragile X syndrome. Epilepsy Curr. 2009 Jul-Aug; 9(4):108-12. PMID: 19693328; PMCID: PMC2728488.
    77. Dodds ED, Tassone F, Hagerman P, Lebrilla CB. Polymerase chain reaction, nuclease digestion, and mass spectrometry based assay for the trinucleotide repeat status of the fragile X mental retardation 1 gene. Anal Chem. 2009 Jul 01; 81(13):5533-40. PMID: 19514725; PMCID: PMC2744861.
    78. Zhang L, Coffey S, Lua LL, Greco CM, Schafer JA, Brunberg J, Borodyanskaya M, Agius MA, Apperson M, Leehey M, Tartaglia N, Tassone F, Hagerman P, Hagerman RJ. FMR1 premutation in females diagnosed with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 Jul; 80(7):812-4. PMID: 19531693.
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    79. Fernandez-Carvajal I, Lopez Posadas B, Pan R, Raske C, Hagerman P, Tassone F. Expansion of an FMR1 grey-zone allele to a full mutation in two generations. J Mol Diagn. 2009 Jul; 11(4):306-10. PMID: 19525339; PMCID: PMC2710706.
    80. Iwahashi C, Tassone F, Hagerman RJ, Yasui D, Parrott G, Nguyen D, Mayeur G, Hagerman P. A quantitative ELISA assay for the fragile x mental retardation 1 protein. J Mol Diagn. 2009 Jul; 11(4):281-9. PMID: 19460937; PMCID: PMC2710703.
    81. Fernandez-Carvajal I, Walichiewicz P, Xiaosen X, Pan R, Hagerman P, Tassone F. Screening for expanded alleles of the FMR1 gene in blood spots from newborn males in a Spanish population. J Mol Diagn. 2009 Jul; 11(4):324-9. PMID: 19460941; PMCID: PMC2710709.
    82. Bourgeois JA, Coffey SM, Rivera SM, Hessl D, Gane LW, Tassone F, Greco C, Finucane B, Nelson L, Berry-Kravis E, Grigsby J, Hagerman P, Hagerman RJ. A review of fragile X premutation disorders: expanding the psychiatric perspective. J Clin Psychiatry. 2009 Jun; 70(6):852-62. PMID: 19422761; PMCID: PMC2705685.
    83. Hagerman P. Incomplete financial disclosure in a commentary on testing for fragile X gene mutations throughout the life span. JAMA. 2009 Feb 11; 301(6):601-2. PMID: 19211466.
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    173. Tassone F, Hagerman RJ, Loesch DZ, Lachiewicz A, Taylor AK, Hagerman P. Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA. Am J Med Genet. 2000 Sep 18; 94(3):232-6. PMID: 10995510.
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    174. Tassone F, Hagerman RJ, Taylor AK, Mills JB, Harris SW, Gane LW, Hagerman P. Clinical involvement and protein expression in individuals with the FMR1 premutation. Am J Med Genet. 2000 Mar 13; 91(2):144-52. PMID: 10748416.
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    175. Tassone F, Hagerman RJ, Taylor AK, Gane LW, Godfrey TE, Hagerman P. Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am J Hum Genet. 2000 Jan; 66(1):6-15. PMID: 10631132; PMCID: PMC1288349.
    176. Hagerman P. Transient electric birefringence for determining global conformations of nonhelix elements and protein-induced bends in RNA. Methods Enzymol. 2000; 317:440-53. PMID: 10829294.
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    177. Tassone F, Hagerman RJ, Chamberlain WD, Hagerman P. Transcription of the FMR1 gene in individuals with fragile X syndrome. Am J Med Genet. 2000; 97(3):195-203. PMID: 11449488.
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    178. van Oppen MJ, Hislop NR, Hagerman P, Miller DJ. Gene content and organization in a segment of the mitochondrial genome of the scleractinian coral Acropora tenuis: major differences in gene order within the anthozoan subclass zoantharia. Mol Biol Evol. 1999 Dec; 16(12):1812-5. PMID: 10605123.
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    179. Frazer-Abel AA, Hagerman P. Determination of the angle between the acceptor and anticodon stems of a truncated mitochondrial tRNA. J Mol Biol. 1999 Jan 15; 285(2):581-93. PMID: 9878431.
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    180. Mills JB, Vacano E, Hagerman P. Flexibility of single-stranded DNA: use of gapped duplex helices to determine the persistence lengths of poly(dT) and poly(dA). J Mol Biol. 1999 Jan 08; 285(1):245-57. PMID: 9878403.
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    181. Friederich MW, Vacano E, Hagerman P. Global flexibility of tertiary structure in RNA: yeast tRNAPhe as a model system. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3572-7. PMID: 9520407; PMCID: PMC19877.
    182. Orr JW, Hagerman P, Williamson JR. Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA. J Mol Biol. 1998 Jan 23; 275(3):453-64. PMID: 9466923.
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    183. Zacharias M, Hagerman P. Influence of static and dynamic bends on the birefringence decay profile of RNA helices: Brownian dynamics simulations. Biophys J. 1997 Jul; 73(1):318-32. PMID: 9199796; PMCID: PMC1180933.
    184. Vacano E, Hagerman P. Analysis of birefringence decay profiles for nucleic acid helices possessing bends: the tau-ratio approach. Biophys J. 1997 Jul; 73(1):306-17. PMID: 9199795; PMCID: PMC1180932.
    185. Friederich MW, Hagerman P. The angle between the anticodon and aminoacyl acceptor stems of yeast tRNA(Phe) is strongly modulated by magnesium ions. Biochemistry. 1997 May 20; 36(20):6090-9. PMID: 9166779.
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    186. Hagerman P. Flexibility of RNA. Annu Rev Biophys Biomol Struct. 1997; 26:139-56. PMID: 9241416.
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    187. Hagerman P. Sometimes a great motion: the application of transient electric birefringence to the study of macromolecular structure. Curr Opin Struct Biol. 1996 Oct; 6(5):643-9. PMID: 8913687.
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    188. Hagerman P. Do basic region-leucine zipper proteins bend their DNA targets ... does it matter? Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):9993-6. PMID: 8816735; PMCID: PMC38322.
    189. Amiri KM, Hagerman P. The global conformation of an active hammerhead RNA during the process of self-cleavage. J Mol Biol. 1996 Aug 16; 261(2):125-34. PMID: 8757281.
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    190. Hagerman KR, Hagerman P. Helix rigidity of DNA: the meroduplex as an experimental paradigm. J Mol Biol. 1996 Jul 12; 260(2):207-23. PMID: 8764401.
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    191. Hagerman P, Amiri KM. Hammering away at RNA global structure. Curr Opin Struct Biol. 1996 Jun; 6(3):317-21. PMID: 8804834.
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    192. Hagerman P, Tinoco I. From sequence to structure to function. Curr Opin Struct Biol. 1996 06 01; 6(3):277-80. PMID: 8805487.
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    193. Zacharias M, Hagerman P. The influence of symmetric internal loops on the flexibility of RNA. J Mol Biol. 1996 Mar 29; 257(2):276-89. PMID: 8609623.
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    194. Leehey MA, Squassoni CA, Friederich MW, Mills JB, Hagerman P. A noncanonical tertiary conformation of a human mitochondrial transfer RNA. Biochemistry. 1995 Dec 19; 34(50):16235-9. PMID: 8845346.
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    195. Zacharias M, Hagerman P. The bend in RNA created by the trans-activation response element bulge of human immunodeficiency virus is straightened by arginine and by Tat-derived peptide. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6052-6. PMID: 7597079; PMCID: PMC41640.
    196. Friederich MW, Gast FU, Vacano E, Hagerman P. Determination of the angle between the anticodon and aminoacyl acceptor stems of yeast phenylalanyl tRNA in solution. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4803-7. PMID: 7761403; PMCID: PMC41795.
    197. Zacharias M, Hagerman P. Bulge-induced bends in RNA: quantification by transient electric birefringence. J Mol Biol. 1995 Mar 31; 247(3):486-500. PMID: 7536250.
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    198. Hodges-Garcia Y, Hagerman P. Investigation of the influence of cytosine methylation on DNA flexibility. J Biol Chem. 1995 Jan 06; 270(1):197-201. PMID: 7814373.
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    199. Amiri KM, Hagerman P. Global conformation of a self-cleaving hammerhead RNA. Biochemistry. 1994 Nov 15; 33(45):13172-7. PMID: 7947724.
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    200. Olmsted MC, Hagerman P. Excess counterion accumulation around branched nucleic acids. J Mol Biol. 1994 Nov 11; 243(5):919-29. PMID: 7525974.
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    201. Shen Z, Hagerman P. Conformation of the central, three-helix junction of the 5 S ribosomal RNA of Sulfolobus acidocaldarius. J Mol Biol. 1994 Aug 19; 241(3):415-30. PMID: 7520504.
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    202. Mills JB, Cooper JP, Hagerman P. Electrophoretic evidence that single-stranded regions of one or more nucleotides dramatically increase the flexibility of DNA. Biochemistry. 1994 Feb 22; 33(7):1797-803. PMID: 8110781.
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    203. Gast FU, Amiri KM, Hagerman P. Interhelix geometry of stems I and II of a self-cleaving hammerhead RNA. Biochemistry. 1994 Feb 22; 33(7):1788-96. PMID: 7509191.
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    204. Hodges-Garcia Y, Hagerman P. Cytosine methylation can induce local distortions in the structure of duplex DNA. Biochemistry. 1992 Aug 25; 31(33):7595-9. PMID: 1510946.
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    205. Hagerman P. Straightening out the bends in curved DNA. Biochim Biophys Acta. 1992 Jun 15; 1131(2):125-32. PMID: 1610891.
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    206. Gast FU, Hagerman P. Electrophoretic and hydrodynamic properties of duplex ribonucleic acid molecules transcribed in vitro: evidence that A-tracts do not generate curvature in RNA. Biochemistry. 1991 Apr 30; 30(17):4268-77. PMID: 2021619.
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    207. Hagerman P. RNA 'tetraloops': living in syn. Curr Biol. 1991 Feb; 1(1):50-2. PMID: 15336208.
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    208. Cooper JP, Hagerman P. Analysis of fluorescence energy transfer in duplex and branched DNA molecules. Biochemistry. 1990 Oct 02; 29(39):9261-8. PMID: 2271593.
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    209. Hagerman P, Ramadevi VA. Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. I. Computational analysis. J Mol Biol. 1990 Mar 20; 212(2):351-62. PMID: 2319603.
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    210. Taylor WH, Hagerman P. Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat. J Mol Biol. 1990 Mar 20; 212(2):363-76. PMID: 2319604.
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    211. Hagerman P. Pyrimidine 5-methyl groups influence the magnitude of DNA curvature. Biochemistry. 1990 Feb 27; 29(8):1980-3. PMID: 2328230.
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    212. Hagerman P. Sequence-directed curvature of DNA. Annu Rev Biochem. 1990; 59:755-81. PMID: 2197990.
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    213. Cooper JP, Hagerman P. Geometry of a branched DNA structure in solution. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7336-40. PMID: 2798413; PMCID: PMC298056.
    214. Hodges-Garcia Y, Hagerman P, Pettijohn DE. DNA ring closure mediated by protein HU. J Biol Chem. 1989 Sep 05; 264(25):14621-3. PMID: 2768236.
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    215. Hagerman P. Flexibility of DNA. Annu Rev Biophys Biophys Chem. 1988; 17:265-86. PMID: 3293588.
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    216. Cooper JP, Hagerman P. Gel electrophoretic analysis of the geometry of a DNA four-way junction. J Mol Biol. 1987 Dec 20; 198(4):711-9. PMID: 2828644.
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    217. Hagerman RJ, Jackson AW, Levitas A, Braden M, McBogg P, Kemper M, McGavran L, Berry R, Matus I, Hagerman P. Oral folic acid versus placebo in the treatment of males with the fragile X syndrome. Am J Med Genet. 1986 Jan-Feb; 23(1-2):241-62. PMID: 3513567.
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    218. Hagerman RJ, McBogg P, Hagerman P. The fragile X syndrome: history, diagnosis, and treatment. J Dev Behav Pediatr. 1983 Jun; 4(2):122-30. PMID: 6348096.
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