Robert Fairclough • UC Davis Profiles

Robert H Fairclough

Title(s)	Professor Emeritus, Med: Neurology
School	School of Medicine
Address	510 C Med Neurosciences CA 95616
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Research

Research Activities and Funding

STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
NIH/NINDS P01NS024304Jan 1, 1987 - Sep 30, 1992
Role: Principal Investigator

ORNG Applications

Student Projects

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition. Int J Mol Sci. 2024 Jul 16; 25(14). Kwon HC, Fairclough RH, Chen TY. PMID: 39063037; PMCID: PMC11276645.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Biophysical and Pharmacological Insights to CLC Chloride Channels. Handb Exp Pharmacol. 2024; 283:1-34. Kwon HC, Fairclough RH, Chen TY. PMID: 35768555.

View in: PubMed Mentions: 1 Fields:
Pha Pharmacology
Translation:Humans
Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel. PLoS One. 2020; 15(12):e0240704. Kwon HC, Yu Y, Fairclough RH, Chen TY. PMID: 33362212; PMCID: PMC7757909.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Corrigendum to “Structural characterization of the main immunogenic region of the Torpedo acetylcholine receptor” [Mol. Immunol. 58 (2014) 116–131]. Molecular Immunology. 2014 May 1; 59(1):117. Morell MS, Trinh TV, Gudipati GE, Friend FA, Page PN, Agius AM, Richman RD, Fairclough FR. .

View in: Publisher Site Mentions:
Design, synthesis, and characterization of a 39 amino acid peptide mimic of the main immunogenic region of the Torpedo acetylcholine receptor. Mol Immunol. 2014 May; 59(1):79-90. Trinh VB, Foster AJ, Fairclough RH. PMID: 24491490.

View in: PubMed Mentions: 4 Fields:
All Allergy and Immunology Mol Molecular Biology
Translation:Animals Cells
Structural characterization of the main immunogenic region of the Torpedo acetylcholine receptor. Mol Immunol. 2014 Mar; 58(1):116-31. Morell SW, Trinh VB, Gudipati E, Friend A, Page NA, Agius MA, Richman DP, Fairclough RH. PMID: 24333757.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology Mol Molecular Biology
Translation:Humans Animals Cells
Redistribution of terbium ions across acetylcholine receptor-enriched membranes induced by agonist desensitization. Biophys J. 2009 Apr 08; 96(7):2637-47. Lee TE, Chuang AR, Marek MS, Doniach S, Fairclough RH. PMID: 19348747; PMCID: PMC2711283.

View in: PubMed Mentions: 1 Fields:
Bio Biophysics
Translation:Animals Cells
Recalled to life: resurrection of diffusion-enhanced fluorescence energy transfer. Biophys J. 2006 Aug 15; 91(4):1143-4. Fairclough RH. PMID: 16751244; PMCID: PMC1518659.

View in: PubMed Mentions: 1 Fields:
Bio Biophysics
Translation:Humans Animals Cells
Three forms of immune myasthenia. Ann N Y Acad Sci. 2003 Sep; 998:453-6. Agius MA, Richman DP, Fairclough RH, Aarli J, Gilhus NE, Romi F. PMID: 14592914.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans PHPublic Health
Agonist-induced transitions of the acetylcholine receptor. Ann N Y Acad Sci. 2003 Sep; 998:101-13. Fairclough RH, Agius MA, Gudipati E, Silvian L, Hamaoka B, Beltzner CC, Lin MY, Chuang AR, Richman DP. PMID: 14592867.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Animals Cells
Differential surface accessibility of alpha(187-199) in the Torpedo acetylcholine receptor alpha subunits. J Mol Biol. 1998 Sep 18; 282(2):317-30. Fairclough RH, Twaddle GM, Gudipati E, Lin MY, Richman DP. PMID: 9735290.

View in: PubMed Mentions: 2 Fields:
Mol Molecular Biology
Translation:Animals Cells
Mapping the mAb 383C epitope to alpha 2(187-199) of the Torpedo acetylcholine receptor on the three-dimensional model. J Mol Biol. 1998 Sep 18; 282(2):301-15. Fairclough RH, Twaddle GM, Gudipati E, Stone RJ, Richman DP, Burkwall DA, Josephs R. PMID: 9735289.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology
Translation:Animals Cells
Measurement of the dissociation rate constants of alpha-bungarotoxin from the acetylcholine receptor low- and high-affinity tubocurarine sites. Ann N Y Acad Sci. 1998 May 13; 841:108-10. Lin MY, Twaddle GM, Gudipati E, Fairclough RH. PMID: 9668228.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Cells
Rhodamine-labeled alpha-bungarotoxin allows visualization of end plates in congenital end plate acetylcholinesterase deficiency (CEAD). Ann N Y Acad Sci. 1998 May 13; 841:207-9. Agius MA, Maselli RA, Zhu S, Fairclough RH, Lin MY, Ellis W. PMID: 9668242.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Humans Cells
Distance between alpha-Cys 192 of the acetylcholine receptor and rhodamine-labeled alpha-bungarotoxin complexed to the receptor. Ann N Y Acad Sci. 1998 May 13; 841:104-7. Gudipati E, Silvian L, Katta V, Fairclough RH. PMID: 9668227.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. Agius MA, Zhu S, Kirvan CA, Schafer AL, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. PMID: 9668284.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Humans Animals Cells
MAb 383C binds to the alpha-subunit of the acetylcholine receptor associated with the high-affinity tubocurarine site. Ann N Y Acad Sci. 1998 May 13; 841:101-3. Lin MY, Twaddle GM, Gudipati E, Richman DP, Fairclough RH. PMID: 9668226.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
Epitope spreading in experimental autoimmune myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:365-7. Agius MA, Twaddle GM, Fairclough RH. PMID: 9668260.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Animals Cells
Antirapsyn antibodies in chronic procainamide-associated myopathy (CPAM). Ann N Y Acad Sci. 1998 May 13; 841:527-9. Agius MA, Zhu S, Fairclough RH. PMID: 9668287.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Animals
A role for alpha(187-199) in the conversion of agonist binding energy to the opening of the acetylcholine receptor ion channel. Ann N Y Acad Sci. 1998 May 13; 841:87-92. Fairclough RH, Gudipati E, Lin MY, Twaddle GM, Richman DP, Burkwall DA, Josephs R. PMID: 9668223.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
Antibody effector mechanisms in myasthenia gravis. The complement hypothesis. Ann N Y Acad Sci. 1998 May 13; 841:450-65. Richman DP, Agius MA, Kirvan CA, Gomez CM, Fairclough RH, Dupont BL, Maselli RA. PMID: 9668274.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Animals Cells
Antibodies to AChR, synapse-organizing proteins, titin, and other muscle proteins in Morvan's fibrillary chorea. Ann N Y Acad Sci. 1998 May 13; 841:522-4. Agius MA, Zhu S, Lee EK, Aarli JA, Kirvan C, Fairclough RH, Maselli R. PMID: 9668285.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Animals Cells
An immunogenic self-peptide for T cells in mice with experimental myasthenia. Ann N Y Acad Sci. 1993 Jun 21; 681:1-4. Xu Q, Agius M, Gudipati E, Fairclough RH, Richman DP. PMID: 8357155.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
Effects of D-penicillamine on multiple immunogenic epitopes of the acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:335-8. Xu Q, Fairclough RH, Richman DP. PMID: 7689309.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals
Effector mechanisms of myasthenic antibodies. Ann N Y Acad Sci. 1993 Jun 21; 681:264-73. Richman DP, Wollmann RL, Maselli RA, Gomez CM, Corey AL, Agius MA, Fairclough RH. PMID: 8357166.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Animals Cells
Imaging ligand binding sites on the Torpedo acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:113-25. Fairclough RH, Josephs R, Richman DP. PMID: 7689302.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Animals Cells
Characterization of the epitope of an antiacetylcholine receptor antibody that inhibits fifty percent of alpha-bungarotoxin binding. Ann N Y Acad Sci. 1993 Jun 21; 681:175-8. Xu Q, Twaddle GM, Richman DP, Fairclough RH. PMID: 7689304.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Cells
Interaction of antiacetylcholine receptor monoclonal antibodies with the acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:172-4. Xu Q, Fairclough RH, Richman DP. PMID: 7689303.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Animals Cells
Noninflammatory immune mechanisms in diseases of the nervous system. Res Publ Assoc Res Nerv Ment Dis. 1990; 68:55-65. Richman DP, Fairclough RH, Xu Q, Agius MA. PMID: 2183319.

View in: PubMed Mentions: Fields:
Neu Neurology Psy Psychiatry
Translation:Humans
Monoclonal anti-idiotopic antibodies against myasthenia-inducing anti-acetylcholine receptor monoclonal antibodies. Preponderance of nonparatope-directed antibodies affecting antigen binding. J Immunol. 1988 Jan 01; 140(1):62-8. Agius MA, Geannopoulos CJ, Fairclough RH, Richman DP. PMID: 3257231.

View in: PubMed Mentions: 3 Fields:
All Allergy and Immunology
Translation:Animals Cells
Human x human hybridomas from patients with myasthenia gravis: possible tools for idiotypic therapy for myasthenia. Ann N Y Acad Sci. 1987; 505:155-67. Blair DA, Mihovilovic M, Agius MA, Fairclough RH, Richman DP. PMID: 3500665.

View in: PubMed Mentions: Fields:
Sci Science
Translation:Humans Animals Cells
Location of terbium binding sites on acetylcholine receptor-enriched membranes. J Mol Biol. 1986 Jun 20; 189(4):673-80. Fairclough RH, Miake-Lye RC, Stroud RM, Hodgson KO, Doniach S. PMID: 3783687.

View in: PubMed Mentions: 5 Fields:
Mol Molecular Biology
Translation:Animals Cells
Subunit organization and structure of an acetylcholine receptor. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:9-20. Fairclough RH, Finer-Moore J, Love RA, Kristofferson D, Desmeules PJ, Stroud RM. PMID: 6586365.

View in: PubMed Mentions: 8 Fields:
Bio Biology
Translation:Animals Cells
Structure and function of an acetylcholine receptor. Biophys J. 1982 Jan; 37(1):371-83. Kistler J, Stroud RM, Klymkowsky MW, Lalancette RA, Fairclough RH. PMID: 7055628; PMCID: PMC1329155.

View in: PubMed Mentions: 60 Fields:
Bio Biophysics
Translation:Animals Cells
Fluorescence studies of the location of proteins L7 and L12 on the Escherichia coli ribosome. J Biol Chem. 1981 Jan 10; 256(1):49-53. Lee CC, Wells BD, Fairclough RH, Cantor CR. PMID: 7005217.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Cells
Fluorescence studies of the binding of a yeast tRNAPhe derivative to Escherichia coli ribosomes. J Mol Biol. 1979 Aug 25; 132(4):557-73. Fairclough RH, Cantor CR, Wintermeyer W, Zachau HG. PMID: 393825.

View in: PubMed Mentions: 6 Fields:
Mol Molecular Biology
Translation:Cells
The distance between the anticodon loops of two tRNAs bound to the 70 S Escherichia coli ribosome. J Mol Biol. 1979 Aug 25; 132(4):575-86. Fairclough RH, Cantor CR. PMID: 393826.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Cells
An energy transfer equilibrium between two identical copies of a ribosome-bound fluorescent transfer RNA analogue: implications for the possible structure of codon-anticodon complexes. J Mol Biol. 1979 Aug 25; 132(4):587-601. Fairclough RH, Cantor CR. PMID: 393827.

View in: PubMed Mentions: 3 Fields:
Mol Molecular Biology
Translation:Cells
The use of singlet-singlet energy transfer to study macromolecular assemblies. Methods Enzymol. 1978; 48:347-79. Fairclough RH, Cantor CR. PMID: 345054.

View in: PubMed Mentions: 50 Fields:
Bio Biochemistry
Translation:Cells
Singlet energy transfer studies of the arrangement of proteins in the 30 S Escherichia coli ribosome. J Mol Biol. 1975 Oct 05; 97(4):443-70. Huang KH, Fairclough RH, Cantor CR. PMID: 241859.

View in: PubMed Mentions: 9 Fields:
Mol Molecular Biology
Translation:Cells
Oligonucleotide interactions. II. Differences in base stacking in linear and cyclic deoxythymidine oligonucleotides. Biochemistry. 1969 Sep; 8(9):3610-7. Cantor CR, Fairclough RH, Newmark RA. PMID: 5820657.

View in: PubMed Mentions: 5 Fields:
Bio Biochemistry