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Robert H Fairclough

Title(s)Professor Emeritus, Neurology
SchoolUniversity of California, Davis
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    STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
    NIH/NINDS P01NS024304Jan 1, 1987 - Sep 30, 1992
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Trinh VB, Foster AJ, Fairclough RH. Design, synthesis, and characterization of a 39 amino acid peptide mimic of the main immunogenic region of the Torpedo acetylcholine receptor. Mol Immunol. 2014 May; 59(1):79-90. PMID: 24491490.
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    2. Morell SW, Trinh VB, Gudipati E, Friend A, Page NA, Agius MA, Richman DP, Fairclough RH. Structural characterization of the main immunogenic region of the Torpedo acetylcholine receptor. Mol Immunol. 2014 Mar; 58(1):116-31. PMID: 24333757.
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    3. Lee TE, Chuang AR, Marek MS, Doniach S, Fairclough RH. Redistribution of terbium ions across acetylcholine receptor-enriched membranes induced by agonist desensitization. Biophys J. 2009 Apr 08; 96(7):2637-47. PMID: 19348747.
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    4. Fairclough RH. Recalled to life: resurrection of diffusion-enhanced fluorescence energy transfer. Biophys J. 2006 Aug 15; 91(4):1143-4. PMID: 16751244.
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    5. Fairclough RH, Agius MA, Gudipati E, Silvian L, Hamaoka B, Beltzner CC, Lin MY, Chuang AR, Richman DP. Agonist-induced transitions of the acetylcholine receptor. Ann N Y Acad Sci. 2003 Sep; 998:101-13. PMID: 14592867.
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    6. Agius MA, Richman DP, Fairclough RH, Aarli J, Gilhus NE, Romi F. Three forms of immune myasthenia. Ann N Y Acad Sci. 2003 Sep; 998:453-6. PMID: 14592914.
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    7. Fairclough RH, Twaddle GM, Gudipati E, Lin MY, Richman DP. Differential surface accessibility of alpha(187-199) in the Torpedo acetylcholine receptor alpha subunits. J Mol Biol. 1998 Sep 18; 282(2):317-30. PMID: 9735290.
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    8. Fairclough RH, Twaddle GM, Gudipati E, Stone RJ, Richman DP, Burkwall DA, Josephs R. Mapping the mAb 383C epitope to alpha 2(187-199) of the Torpedo acetylcholine receptor on the three-dimensional model. J Mol Biol. 1998 Sep 18; 282(2):301-15. PMID: 9735289.
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    9. Fairclough RH, Gudipati E, Lin MY, Twaddle GM, Richman DP, Burkwall DA, Josephs R. A role for alpha(187-199) in the conversion of agonist binding energy to the opening of the acetylcholine receptor ion channel. Ann N Y Acad Sci. 1998 May 13; 841:87-92. PMID: 9668223.
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    10. Gudipati E, Silvian L, Katta V, Fairclough RH. Distance between alpha-Cys 192 of the acetylcholine receptor and rhodamine-labeled alpha-bungarotoxin complexed to the receptor. Ann N Y Acad Sci. 1998 May 13; 841:104-7. PMID: 9668227.
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    11. Lin MY, Twaddle GM, Gudipati E, Fairclough RH. Measurement of the dissociation rate constants of alpha-bungarotoxin from the acetylcholine receptor low- and high-affinity tubocurarine sites. Ann N Y Acad Sci. 1998 May 13; 841:108-10. PMID: 9668228.
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    12. Agius MA, Maselli RA, Zhu S, Fairclough RH, Lin MY, Ellis W. Rhodamine-labeled alpha-bungarotoxin allows visualization of end plates in congenital end plate acetylcholinesterase deficiency (CEAD). Ann N Y Acad Sci. 1998 May 13; 841:207-9. PMID: 9668242.
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    13. Richman DP, Agius MA, Kirvan CA, Gomez CM, Fairclough RH, Dupont BL, Maselli RA. Antibody effector mechanisms in myasthenia gravis. The complement hypothesis. Ann N Y Acad Sci. 1998 May 13; 841:450-65. PMID: 9668274.
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    14. Agius MA, Zhu S, Lee EK, Aarli JA, Kirvan C, Fairclough RH, Maselli R. Antibodies to AChR, synapse-organizing proteins, titin, and other muscle proteins in Morvan's fibrillary chorea. Ann N Y Acad Sci. 1998 May 13; 841:522-4. PMID: 9668285.
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    15. Agius MA, Zhu S, Fairclough RH. Antirapsyn antibodies in chronic procainamide-associated myopathy (CPAM). Ann N Y Acad Sci. 1998 May 13; 841:527-9. PMID: 9668287.
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    16. Lin MY, Twaddle GM, Gudipati E, Richman DP, Fairclough RH. MAb 383C binds to the alpha-subunit of the acetylcholine receptor associated with the high-affinity tubocurarine site. Ann N Y Acad Sci. 1998 May 13; 841:101-3. PMID: 9668226.
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    17. Agius MA, Twaddle GM, Fairclough RH. Epitope spreading in experimental autoimmune myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:365-7. PMID: 9668260.
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    18. Agius MA, Zhu S, Kirvan CA, Schafer AL, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. PMID: 9668284.
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    19. Xu Q, Fairclough RH, Richman DP. Interaction of antiacetylcholine receptor monoclonal antibodies with the acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:172-4. PMID: 7689303.
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    20. Xu Q, Fairclough RH, Richman DP. Effects of D-penicillamine on multiple immunogenic epitopes of the acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:335-8. PMID: 7689309.
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    21. Xu Q, Agius M, Gudipati E, Fairclough RH, Richman DP. An immunogenic self-peptide for T cells in mice with experimental myasthenia. Ann N Y Acad Sci. 1993 Jun 21; 681:1-4. PMID: 8357155.
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    22. Fairclough RH, Josephs R, Richman DP. Imaging ligand binding sites on the Torpedo acetylcholine receptor. Ann N Y Acad Sci. 1993 Jun 21; 681:113-25. PMID: 7689302.
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    23. Xu Q, Twaddle GM, Richman DP, Fairclough RH. Characterization of the epitope of an antiacetylcholine receptor antibody that inhibits fifty percent of alpha-bungarotoxin binding. Ann N Y Acad Sci. 1993 Jun 21; 681:175-8. PMID: 7689304.
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    24. Richman DP, Wollmann RL, Maselli RA, Gomez CM, Corey AL, Agius MA, Fairclough RH. Effector mechanisms of myasthenic antibodies. Ann N Y Acad Sci. 1993 Jun 21; 681:264-73. PMID: 8357166.
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    25. Richman DP, Fairclough RH, Xu Q, Agius MA. Noninflammatory immune mechanisms in diseases of the nervous system. Res Publ Assoc Res Nerv Ment Dis. 1990; 68:55-65. PMID: 2183319.
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    26. Agius MA, Geannopoulos CJ, Fairclough RH, Richman DP. Monoclonal anti-idiotopic antibodies against myasthenia-inducing anti-acetylcholine receptor monoclonal antibodies. Preponderance of nonparatope-directed antibodies affecting antigen binding. J Immunol. 1988 Jan 01; 140(1):62-8. PMID: 3257231.
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    27. Blair DA, Mihovilovic M, Agius MA, Fairclough RH, Richman DP. Human x human hybridomas from patients with myasthenia gravis: possible tools for idiotypic therapy for myasthenia. Ann N Y Acad Sci. 1987; 505:155-67. PMID: 3500665.
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    28. Fairclough RH, Miake-Lye RC, Stroud RM, Hodgson KO, Doniach S. Location of terbium binding sites on acetylcholine receptor-enriched membranes. J Mol Biol. 1986 Jun 20; 189(4):673-80. PMID: 3783687.
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    29. Fairclough RH, Finer-Moore J, Love RA, Kristofferson D, Desmeules PJ, Stroud RM. Subunit organization and structure of an acetylcholine receptor. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 1:9-20. PMID: 6586365.
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    30. Kistler J, Stroud RM, Klymkowsky MW, Lalancette RA, Fairclough RH. Structure and function of an acetylcholine receptor. Biophys J. 1982 Jan; 37(1):371-83. PMID: 7055628.
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    31. Lee CC, Wells BD, Fairclough RH, Cantor CR. Fluorescence studies of the location of proteins L7 and L12 on the Escherichia coli ribosome. J Biol Chem. 1981 Jan 10; 256(1):49-53. PMID: 7005217.
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    32. Fairclough RH, Cantor CR. An energy transfer equilibrium between two identical copies of a ribosome-bound fluorescent transfer RNA analogue: implications for the possible structure of codon-anticodon complexes. J Mol Biol. 1979 Aug 25; 132(4):587-601. PMID: 393827.
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    33. Fairclough RH, Cantor CR, Wintermeyer W, Zachau HG. Fluorescence studies of the binding of a yeast tRNAPhe derivative to Escherichia coli ribosomes. J Mol Biol. 1979 Aug 25; 132(4):557-73. PMID: 393825.
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    34. Fairclough RH, Cantor CR. The distance between the anticodon loops of two tRNAs bound to the 70 S Escherichia coli ribosome. J Mol Biol. 1979 Aug 25; 132(4):575-86. PMID: 393826.
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    35. Fairclough RH, Cantor CR. The use of singlet-singlet energy transfer to study macromolecular assemblies. Methods Enzymol. 1978; 48:347-79. PMID: 345054.
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    36. Huang KH, Fairclough RH, Cantor CR. Singlet energy transfer studies of the arrangement of proteins in the 30 S Escherichia coli ribosome. J Mol Biol. 1975 Oct 05; 97(4):443-70. PMID: 241859.
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    37. Cantor CR, Fairclough RH, Newmark RA. Oligonucleotide interactions. II. Differences in base stacking in linear and cyclic deoxythymidine oligonucleotides. Biochemistry. 1969 Sep; 8(9):3610-7. PMID: 5820657.
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