Samantha Paige Harris

InstitutionUniversity of California Davis
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Mechanisms of Disease in a Novel Feline Model of Familial Hypertrophic
    NIH/NHLBI R21HL093603Jul 15, 2010 - Apr 30, 2014
    Role: Principal Investigator
    Role of Myosin Binding Protein-C in the Regulation of Myocardial Contraction
    NIH/NHLBI R01HL080367Sep 1, 2005 - Apr 30, 2022
    Role: Principal Investigator
    NIH/NHLBI F32HL010161Jul 1, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. van Dijk SJ, Kooiker KB, Napierski NC, Touma KD, Mazzalupo S, Harris S. Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation. J Mol Cell Cardiol. 2018 May 03; 119:116-124. PMID: 29729251.
      View in: PubMed
    2. McNamara JW, Li A, Lal S, Bos JM, Harris S, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG. MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PLoS One. 2017; 12(6):e0180064. PMID: 28658286.
      View in: PubMed
    3. McNamara JW, Li A, Smith NJ, Lal S, Graham RM, Kooiker KB, van Dijk SJ, Remedios CGD, Harris S, Cooke R. Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. J Mol Cell Cardiol. 2016 05; 94:65-71. PMID: 27021517.
      View in: PubMed
    4. Harris S, Belknap B, Van Sciver RE, White HD, Galkin VE. C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):1558-63. PMID: 26831109; PMCID: PMC4760775.
    5. van Dijk SJ, Bezold Kooiker K, Mazzalupo S, Yang Y, Kostyukova AS, Mustacich DJ, Hoye ER, Stern JA, Kittleson MD, Harris S. The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency. Arch Biochem Biophys. 2016 07 01; 601:133-40. PMID: 26777460.
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    6. Mun JY, Kensler RW, Harris S, Craig R. The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position. J Mol Cell Cardiol. 2016 Feb; 91:141-7. PMID: 26718724; PMCID: PMC4764391 [Available on 02/01/17].
    7. Kittleson MD, Meurs KM, Harris S. The genetic basis of hypertrophic cardiomyopathy in cats and humans. J Vet Cardiol. 2015 Dec; 17 Suppl 1:S53-73. PMID: 26776594.
      View in: PubMed
    8. Belknap B, Harris S, White HD. Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C. Biochemistry. 2014 Oct 28; 53(42):6717-24. PMID: 25265574; PMCID: PMC4211651.
    9. van Dijk SJ, Bezold KL, Harris S. Earning stripes: myosin binding protein-C interactions with actin. Pflugers Arch. 2014 Mar; 466(3):445-50. PMID: 24442149; PMCID: PMC4306388.
    10. Bezold KL, Shaffer JF, Khosa JK, Hoye ER, Harris S. A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin. J Biol Chem. 2013 Jul 26; 288(30):21496-505. PMID: 23782699; PMCID: PMC3724610.
    11. Bers DM, Harris S. Translational medicine: to the rescue of the failing heart. Nature. 2011 May 05; 473(7345):36-9. PMID: 21544138.
      View in: PubMed
    12. Harris S, Lyons RG, Bezold KL. In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament. Circ Res. 2011 Mar 18; 108(6):751-64. PMID: 21415409; PMCID: PMC3076008.
    13. Shaffer JF, Wong P, Bezold KL, Harris S. Functional differences between the N-terminal domains of mouse and human myosin binding protein-C. J Biomed Biotechnol. 2010; 2010:789798. PMID: 20379391; PMCID: PMC2850553.
    14. Jia W, Shaffer JF, Harris S, Leary JA. Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis. J Proteome Res. 2010 Apr 05; 9(4):1843-53. PMID: 20151718; PMCID: PMC3000796.
    15. Shaffer JF, Kensler RW, Harris S. The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner. J Biol Chem. 2009 May 01; 284(18):12318-27. PMID: 19269976; PMCID: PMC2673300.
    16. Razumova MV, Bezold KL, Tu AY, Regnier M, Harris S. Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. J Gen Physiol. 2008 Nov; 132(5):575-85. PMID: 18955596; PMCID: PMC2571974.
    17. Jeffries CM, Whitten AE, Harris S, Trewhella J. Small-angle X-ray scattering reveals the N-terminal domain organization of cardiac myosin binding protein C. J Mol Biol. 2008 Apr 04; 377(4):1186-99. PMID: 18313073.
      View in: PubMed
    18. Kensler RW, Harris S. The structure of isolated cardiac Myosin thick filaments from cardiac Myosin binding protein-C knockout mice. Biophys J. 2008 Mar 01; 94(5):1707-18. PMID: 17993479; PMCID: PMC2242758.
    19. Harris S, Rostkova E, Gautel M, Moss RL. Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism. Circ Res. 2004 Oct 29; 95(9):930-6. PMID: 15472117.
      View in: PubMed
    20. Palmer BM, Georgakopoulos D, Janssen PM, Wang Y, Alpert NR, Belardi DF, Harris S, Moss RL, Burgon PG, Seidman CE, Seidman JG, Maughan DW, Kass DA. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res. 2004 May 14; 94(9):1249-55. PMID: 15059932.
      View in: PubMed
    21. Korte FS, McDonald KS, Harris S, Moss RL. Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res. 2003 Oct 17; 93(8):752-8. PMID: 14500336.
      View in: PubMed
    22. Harris S, Bartley CR, Hacker TA, McDonald KS, Douglas PS, Greaser ML, Powers PA, Moss RL. Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res. 2002 Mar 22; 90(5):594-601. PMID: 11909824.
      View in: PubMed
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