Sanda I Despa

TitleAsst Prof
InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stewart BD, Scott CE, McCoy TP, Yin G, Despa F, Despa S, Kekenes-Huskey PM. Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes. Cell Calcium. 2018 May; 71:65-74. PMID: 29604965.
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    2. Liu M, Hoskins A, Verma N, Bers DM, Despa S, Despa F. Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium. Biochim Biophys Acta. 2018 May; 1864(5 Pt B):1923-1930. PMID: 29066284.
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    3. Van Steenbergen A, Balteau M, Ginion A, Ferté L, Battault S, Ravenstein CM, Balligand JL, Daskalopoulos EP, Gilon P, Despa F, Despa S, Vanoverschelde JL, Horman S, Koepsell H, Berry G, Hue L, Bertrand L, Beauloye C. Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart. Sci Rep. 2017 Jan 27; 7:41166. PMID: 28128227.
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    4. Liu M, Verma N, Peng X, Srodulski S, Morris A, Chow M, Hersh LB, Chen J, Zhu H, Netea MG, Margulies KB, Despa S, Despa F. Hyperamylinemia Increases IL-1ß Synthesis in the Heart via Peroxidative Sarcolemmal Injury. Diabetes. 2016 09; 65(9):2772-83. PMID: 27335231.
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    5. Popescu I, Galice S, Mohler PJ, Despa S. Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts. Cardiovasc Res. 2016 Aug 01; 111(3):287-94. PMID: 27131508; PMCID: PMC4957489 [Available on 08/01/17].
    6. Despa S, Vigmond E. From Single Myocyte to Whole Heart: The Intricate Dance of Electrophysiology and Modeling. Circ Res. 2016 Jan 22; 118(2):184-6. PMID: 26838308; PMCID: PMC4743900 [Available on 01/22/17].
    7. Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa S. Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport. J Am Heart Assoc. 2015 Aug 27; 4(9):e002183. PMID: 26316524; PMCID: PMC4599504.
    8. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289; PMCID: PMC4376414.
    9. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc. 2014 Aug 21; 3(4). PMID: 25146704.
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    10. Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM. Junctional cleft [Ca²?]i measurements using novel cleft-targeted Ca²? sensors. Circ Res. 2014 Jul 18; 115(3):339-47. PMID: 24871564; PMCID: PMC4132890.
    11. Correll RN, Eder P, Burr AR, Despa S, Davis J, Bers DM, Molkentin JD. Overexpression of the Na+/K+ ATPase a2 but not a1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res. 2014 Jan 17; 114(2):249-256. PMID: 24218169; PMCID: PMC4001807.
    12. Avkiran M, Despa S, Shattock MJ. The salt of the earth: focus on Na? regulation in the cardiac myocyte. J Mol Cell Cardiol. 2013 Aug; 61:1. PMID: 23770060.
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    13. Pavlovic D, Hall AR, Kennington EJ, Aughton K, Boguslavskyi A, Fuller W, Despa S, Bers DM, Shattock MJ. Nitric oxide regulates cardiac intracellular Na? and Ca²? by modulating Na/K ATPase via PKCe and phospholemman-dependent mechanism. J Mol Cell Cardiol. 2013 Aug; 61:164-71. PMID: 23612119; PMCID: PMC3981027.
    14. Despa S, Bers DM. Na? transport in the normal and failing heart - remember the balance. J Mol Cell Cardiol. 2013 Aug; 61:2-10. PMID: 23608603; PMCID: PMC3720717.
    15. Khafaga M, Bossuyt J, Mamikonian L, Li JC, Lee LL, Yarov-Yarovoy V, Despa S, Bers DM. Na?/K?-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20756-61. PMID: 23185013; PMCID: PMC3528502.
    16. Guglielmino K, Jackson K, Harris TR, Vu V, Dong H, Dutrow G, Evans JE, Graham J, Cummings BP, Havel PJ, Chiamvimonvat N, Despa S, Hammock BD, Despa F. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H853-62. PMID: 22865388; PMCID: PMC3469704.
    17. Despa S, Lingrel JB, Bers DM. Na(+)/K)+)-ATPase a2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res. 2012 Sep 01; 95(4):480-6. PMID: 22739122; PMCID: PMC3422081.
    18. Sato D, Despa S, Bers DM. Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes? Biophys J. 2012 Apr 18; 102(8):L31-3. PMID: 22768959; PMCID: PMC3328690.
    19. Camors E, Mohler PJ, Bers DM, Despa S. Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity. J Mol Cell Cardiol. 2012 Jun; 52(6):1240-8. PMID: 22406428; PMCID: PMC3348355.
    20. Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608. PMID: 22275486; PMCID: PMC3303627.
    21. Han F, Bossuyt J, Martin JL, Despa S, Bers DM. Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1363-9. PMID: 20861470; PMCID: PMC3006338.
    22. Bossuyt J, Despa S, Han F, Hou Z, Robia SL, Lingrel JB, Bers DM. Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J Biol Chem. 2009 Sep 25; 284(39):26749-57. PMID: 19638348; PMCID: PMC2785363.
    23. Han F, Tucker AL, Lingrel JB, Despa S, Bers DM. Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. Am J Physiol Cell Physiol. 2009 Sep; 297(3):C699-705. PMID: 19570895; PMCID: PMC2740389.
    24. Bers DM, Despa S. Na/K-ATPase--an integral player in the adrenergic fight-or-flight response. Trends Cardiovasc Med. 2009 May; 19(4):111-8. PMID: 19818946; PMCID: PMC2761231.
    25. Bers DM, Despa S. Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling. IUBMB Life. 2009 Mar; 61(3):215-21. PMID: 19243007; PMCID: PMC2669704.
    26. Despa S, Tucker AL, Bers DM. Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes. Circulation. 2008 Apr 08; 117(14):1849-55. PMID: 18362230; PMCID: PMC2854005.
    27. Despa S, Bers DM. Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C321-7. PMID: 17392375.
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    28. Berry RG, Despa S, Fuller W, Bers DM, Shattock MJ. Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovasc Res. 2007 Jan 01; 73(1):92-100. PMID: 17157829.
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    29. Han F, Bossuyt J, Despa S, Tucker AL, Bers DM. Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res. 2006 Dec 08; 99(12):1376-83. PMID: 17095720.
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    30. Bers DM, Despa S, Bossuyt J. Regulation of Ca2+ and Na+ in normal and failing cardiac myocytes. Ann N Y Acad Sci. 2006 Oct; 1080:165-77. PMID: 17132783.
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    31. Bossuyt J, Despa S, Martin JL, Bers DM. Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J Biol Chem. 2006 Oct 27; 281(43):32765-73. PMID: 16943195.
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    32. Bers DM, Despa S. Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts. J Pharmacol Sci. 2006; 100(5):315-22. PMID: 16552170.
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    33. Baron S, Caplanusi A, van de Ven M, Radu M, Despa S, Lambrichts I, Ameloot M, Steels P, Smets I. Role of mitochondrial Na+ concentration, measured by CoroNa red, in the protection of metabolically inhibited MDCK cells. J Am Soc Nephrol. 2005 Dec; 16(12):3490-7. PMID: 16221870.
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    34. Brette F, Despa S, Bers DM, Orchard CH. Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes. J Mol Cell Cardiol. 2005 Nov; 39(5):804-12. PMID: 16198369.
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    35. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res. 2005 Aug 05; 97(3):252-9. PMID: 16002746.
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    36. Despa S, Kockskämper J, Blatter LA, Bers DM. Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy. Biophys J. 2004 Aug; 87(2):1360-8. PMID: 15298938; PMCID: PMC1304474.
    37. Smets I, Caplanusi A, Despa S, Molnar Z, Radu M, VandeVen M, Ameloot M, Steels P. Ca2+ uptake in mitochondria occurs via the reverse action of the Na+/Ca2+ exchanger in metabolically inhibited MDCK cells. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F784-94. PMID: 14665432.
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    38. Despa S, Bers DM. Na/K pump current and [Na](i) in rabbit ventricular myocytes: local [Na](i) depletion and Na buffering. Biophys J. 2003 Jun; 84(6):4157-66. PMID: 12770918; PMCID: PMC1302994.
    39. Bers DM, Barry WH, Despa S. Intracellular Na+ regulation in cardiac myocytes. Cardiovasc Res. 2003 Mar 15; 57(4):897-912. PMID: 12650868.
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    40. Ginsburg KS, Weber CR, Despa S, Bers DM. Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes. Ann N Y Acad Sci. 2002 Nov; 976:157-8. PMID: 12502556.
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    41. Despa S, Islam MA, Weber CR, Pogwizd SM, Bers DM. Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 2002 May 28; 105(21):2543-8. PMID: 12034663.
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    42. Despa S, Islam MA, Pogwizd SM, Bers DM. Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol. 2002 Feb 15; 539(Pt 1):133-43. PMID: 11850507; PMCID: PMC2290132.