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Wei Yao

Title(s)Adjunct Professor, INTERNAL MEDICINE
SchoolUniversity of California, Davis
Phone916-734-0763
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang H, Xiao B, Jiang L, Yao W, Shen H, Xiang X. Inhibition of mesenchymal stromal cells' chemotactic effect to ameliorate paraquat-induced pulmonary fibrosis. Toxicol Lett. 2019 Jun 01; 307:1-10. PMID: 30658152.
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    2. Cortez-Toledo E, Rose M, Agu E, Dahlenburg H, Yao W, Nolta JA, Zhou P. Enhancing Retention of Human Bone Marrow Mesenchymal Stem Cells with Prosurvival Factors Promotes Angiogenesis in a Mouse Model of Limb Ischemia. Stem Cells Dev. 2019 01 15; 28(2):114-119. PMID: 30398391.
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    3. Awan B, Turkov D, Schumacher C, Jacobo A, McEnerney A, Ramsey A, Xu G, Park D, Kalomoiris S, Yao W, Jao LE, Allende ML, Lebrilla CB, Fierro FA. FGF2 Induces Migration of Human Bone Marrow Stromal Cells by Increasing Core Fucosylations on N-Glycans of Integrins. Stem Cell Reports. 2018 08 14; 11(2):325-333. PMID: 29983388.
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    4. Kot A, Zhong ZA, Zhang H, Lay YE, Lane NE, Yao W. Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells. J Mol Endocrinol. 2017 11; 59(4):351-363. PMID: 28871061.
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    5. Zhang H, Kot A, Lay YE, Fierro FA, Chen H, Lane NE, Yao W. Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med. 2017 10; 6(10):1880-1893. PMID: 28792122.
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    6. Zhong ZA, Kot A, Lay YE, Zhang H, Jia J, Lane NE, Yao W. Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition. J Bone Miner Res. 2017 Sep; 32(9):1841-1852. PMID: 28569405.
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    7. Dai WW, Wang LB, Jin GQ, Wu HJ, Zhang J, Wang CL, Wei YJ, Lee JH, Lay YE, Yao W. Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro. Planta Med. 2017 Jul; 83(11):888-894. PMID: 28388784.
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    8. Mohan G, Lay EY, Berka H, Ringwood L, Kot A, Chen H, Yao W, Lane NE. A Novel Hybrid Compound LLP2A-Ale Both Prevented and Rescued the Osteoporotic Phenotype in a Mouse Model of Glucocorticoid-Induced Osteoporosis. Calcif Tissue Int. 2017 01; 100(1):67-79. PMID: 27679514.
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    9. Yao W, Lay YE, Kot A, Liu R, Zhang H, Chen H, Lam K, Lane NE. Improved Mobilization of Exogenous Mesenchymal Stem Cells to Bone for Fracture Healing and Sex Difference. Stem Cells. 2016 10; 34(10):2587-2600. PMID: 27334693.
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    10. Zhong ZA, Sun W, Chen H, Zhang H, Lane NE, Yao W. Inactivation of the Progesterone Receptor in Mx1+ Cells Potentiates Osteogenesis in Calvaria but Not in Long Bone. PLoS One. 2015; 10(10):e0139490. PMID: 26431032.
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    11. Yao W, Dai W, Jiang L, Lay EY, Zhong Z, Ritchie RO, Li X, Ke H, Lane NE. Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength. Osteoporos Int. 2016 Jan; 27(1):283-294. PMID: 26384674.
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    12. Dai W, Zhang H, Zhong ZA, Jiang L, Chen H, Lay YA, Kot A, Ritchie RO, Lane NE, Yao W. ß-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes. Clin Orthop Relat Res. 2015 Aug; 473(8):2495-504. PMID: 25822452.
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    13. Zhong ZA, Sun W, Chen H, Zhang H, Lay YE, Lane NE, Yao W. Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice. Bone. 2015 Dec; 81:614-619. PMID: 26232373.
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    14. Dai W, Jiang L, Lay YA, Chen H, Jin G, Zhang H, Kot A, Ritchie RO, Lane NE, Yao W. Prevention of glucocorticoid induced bone changes with beta-ecdysone. Bone. 2015 May; 74:48-57. PMID: 25585248.
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    15. Yao W, Lane NE. Targeted delivery of mesenchymal stem cells to the bone. Bone. 2015 Jan; 70:62-5. PMID: 25173607.
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    16. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91. PMID: 25106873.
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    17. Amugongo SK, Yao W, Jia J, Dai W, Lay YA, Jiang L, Harvey D, Zimmermann EA, Schaible E, Dave N, Ritchie RO, Kimmel DB, Lane NE. Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats. Bone. 2014 Oct; 67:257-68. PMID: 25016965.
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    18. Lane NE, Parimi N, Lui LY, Wise BL, Yao W, Lay YA, Cawthon PM, Orwoll E. Association of serum uric acid and incident nonspine fractures in elderly men: the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2014 Jul; 29(7):1701-7. PMID: 24347506.
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    19. Amugongo SK, Yao W, Jia J, Lay YA, Dai W, Jiang L, Walsh D, Li CS, Dave NK, Olivera D, Panganiban B, Ritchie RO, Lane NE. Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass. Osteoporos Int. 2014 Jun; 25(6):1735-50. PMID: 24722767.
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    20. Lane NE, Parimi N, Corr M, Yao W, Cauley JA, Nielson CM, Ix JH, Kado D, Orwoll E. Association of serum fibroblast growth factor 23 (FGF23) and incident fractures in older men: the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2013 Nov; 28(11):2325-32. PMID: 23677793.
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    21. Yao W, Guan M, Jia J, Dai W, Lay YA, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells. 2013 Sep; 31(9):2003-14. PMID: 23818248.
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    22. Yao W, Dai W, Jiang JX, Lane NE. Glucocorticoids and osteocyte autophagy. Bone. 2013 Jun; 54(2):279-84. PMID: 23356984.
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    23. Jia J, Yao W, Amugongo S, Shahnazari M, Dai W, Lay YA, Olvera D, Zimmermann EA, Ritchie RO, Li CS, Alliston T, Lane NE. Prolonged alendronate treatment prevents the decline in serum TGF-ß1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model. Bone. 2013 Jan; 52(1):424-32. PMID: 23088940.
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    24. Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG. Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14092-7. PMID: 22886088.
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    25. Zhong Z, Zylstra-Diegel CR, Schumacher CA, Baker JJ, Carpenter AC, Rao S, Yao W, Guan M, Helms JA, Lane NE, Lang RA, Williams BO. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):E2197-204. PMID: 22745162.
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    26. Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med. 2012 Feb 05; 18(3):456-62. PMID: 22306732.
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    27. Jia J, Yao W, Guan M, Dai W, Shahnazari M, Kar R, Bonewald L, Jiang JX, Lane NE. Glucocorticoid dose determines osteocyte cell fate. FASEB J. 2011 Oct; 25(10):3366-76. PMID: 21705669.
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    28. Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, Chou CC, Pierce RH, Yao W, Lane NE, Laface D, Bowman EP. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011 Jul 15; 187(2):951-9. PMID: 21670317.
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    29. Shahnazari M, Yao W, Wang B, Panganiban B, Ritchie RO, Hagar Y, Lane NE. Differential maintenance of cortical and cancellous bone strength following discontinuation of bone-active agents. J Bone Miner Res. 2011 Mar; 26(3):569-81. PMID: 20839286.
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    30. Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid-induced autophagy in osteocytes. J Bone Miner Res. 2010 Nov; 25(11):2479-88. PMID: 20564240.
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    31. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93. PMID: 20941479.
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    32. Yao W, Dai W, Shahnazari M, Pham A, Chen Z, Chen H, Guan M, Lane NE. Inhibition of the progesterone nuclear receptor during the bone linear growth phase increases peak bone mass in female mice. PLoS One. 2010 Jul 01; 5(7):e11410. PMID: 20625385.
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    33. Finch JL, Tokumoto M, Nakamura H, Yao W, Shahnazari M, Lane N, Slatopolsky E. Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. Am J Physiol Renal Physiol. 2010 Jun; 298(6):F1315-22. PMID: 20200094.
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    34. Lane NE, Yao W. Glucocorticoid-induced bone fragility. Ann N Y Acad Sci. 2010 Mar; 1192:81-3. PMID: 20392221.
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    35. Yao W, Cheng Z, Shahnazari M, Dai W, Johnson ML, Lane NE. Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects. J Bone Miner Res. 2010 Feb; 25(2):190-9. PMID: 19594295.
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    36. Shahnazari M, Yao W, Dai W, Wang B, Ionova-Martin SS, Ritchie RO, Heeren D, Burghardt AJ, Nicolella DP, Kimiecik MG, Lane NE. Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats. Bone. 2010 May; 46(5):1267-74. PMID: 19931661.
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    37. Henley C, Davis J, Miller G, Shatzen E, Cattley R, Li X, Martin D, Yao W, Lane N, Shalhoub V. The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats. Eur J Pharmacol. 2009 Aug 15; 616(1-3):306-13. PMID: 19470383.
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    38. Lane NE, Yao W. Developments in the scientific understanding of osteoporosis. Arthritis Res Ther. 2009; 11(3):228. PMID: 19497136.
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    39. Cheng Z, Yao W, Zimmermann EA, Busse C, Ritchie RO, Lane NE. Prolonged treatments with antiresorptive agents and PTH have different effects on bone strength and the degree of mineralization in old estrogen-deficient osteoporotic rats. J Bone Miner Res. 2009 Feb; 24(2):209-20. PMID: 18847326.
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    40. Shahnazari M, Yao W, Corr M, Lane NE. Targeting the Wnt signaling pathway to augment bone formation. Curr Osteoporos Rep. 2008 Dec; 6(4):142-8. PMID: 19032924.
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    41. Yao W, Cheng Z, Pham A, Busse C, Zimmermann EA, Ritchie RO, Lane NE. Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization. Arthritis Rheum. 2008 Nov; 58(11):3485-97. PMID: 18975341.
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    42. Nicolella DP, Feng JQ, Moravits DE, Bonivitch AR, Wang Y, Dusecich V, Yao W, Lane N, Bonewald LF. Effects of nanomechanical bone tissue properties on bone tissue strain: implications for osteocyte mechanotransduction. J Musculoskelet Neuronal Interact. 2008 Oct-Dec; 8(4):330-1. PMID: 19147962.
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    43. Ritchie RO, Koester KJ, Ionova S, Yao W, Lane NE, Ager JW. Measurement of the toughness of bone: a tutorial with special reference to small animal studies. Bone. 2008 Nov; 43(5):798-812. PMID: 18647665.
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    44. Yao W, Cheng Z, Busse C, Pham A, Nakamura MC, Lane NE. Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice. Arthritis Rheum. 2008 Jun; 58(6):1674-86. PMID: 18512788.
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    45. Johnson KA, Yao W, Lane NE, Naquet P, Terkeltaub RA. Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice. Am J Pathol. 2008 Feb; 172(2):440-53. PMID: 18187567.
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    46. Balooch G, Yao W, Ager JW, Balooch M, Nalla RK, Porter AE, Ritchie RO, Lane NE. The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids. Arthritis Rheum. 2007 Nov; 56(11):3726-37. PMID: 17968931.
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    47. Chaganti RK, Kelman A, Lui L, Yao W, Javaid MK, Bauer D, Nevitt M, Lane NE. Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. Osteoarthritis Cartilage. 2008 May; 16(5):566-71. PMID: 17950630.
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    48. You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. 2008 Jan; 42(1):172-9. PMID: 17997378.
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    49. Sabsovich I, Clark JD, Liao G, Peltz G, Lindsey DP, Jacobs CR, Yao W, Guo TZ, Kingery WS. Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone. 2008 Feb; 42(2):439-51. PMID: 17967568.
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    50. Yao W, Su M, Zhang Q, Tian X, Setterberg RB, Blanton C, Lundy MW, Phipps R, Jee WS. Risedronate did not block the maximal anabolic effect of PTH in aged rats. Bone. 2007 Nov; 41(5):813-9. PMID: 17716965.
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    51. Yao W, Cheng Z, Koester KJ, Ager JW, Balooch M, Pham A, Chefo S, Busse C, Ritchie RO, Lane NE. The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and is a strong predictor of bone strength. Bone. 2007 Nov; 41(5):804-12. PMID: 17825637.
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    52. Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB. Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS One. 2007 Jul 04; 2(7):e586. PMID: 17611621.
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    53. Yao W, Tian XY, Chen J, Setterberg RB, Lundy MW, Chmielzwski P, Froman CA, Jee WS. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats. J Musculoskelet Neuronal Interact. 2007 Apr-Jun; 7(2):119-30. PMID: 17627081.
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    54. Yao W, Farmer R, Cooper R, Chmielewski PA, Tian XY, Setterberg RB, Jee WS, Lundy MW. Simvastatin did not prevent nor restore ovariectomy-induced bone loss in adult rats. J Musculoskelet Neuronal Interact. 2006 Jul-Sep; 6(3):277-83. PMID: 17142950.
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    55. Yao W, Balooch G, Balooch M, Jiang Y, Nalla RK, Kinney J, Wronski TJ, Lane NE. Sequential treatment of ovariectomized mice with bFGF and risedronate restored trabecular bone microarchitecture and mineralization. Bone. 2006 Sep; 39(3):460-9. PMID: 16713415.
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    56. Kelman A, Lui L, Yao W, Krumme A, Nevitt M, Lane NE. Association of higher levels of serum cartilage oligomeric matrix protein and N-telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women. Arthritis Rheum. 2006 Jan; 54(1):236-43. PMID: 16385523.
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    57. Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res. 2006 Mar; 21(3):466-76. PMID: 16491295.
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    58. Hurley M, Yao W, Lane NE. Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). Osteoporos Int. 2005 Dec; 16(12):2080-4. PMID: 16133640.
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    59. Yao W, Hadi T, Jiang Y, Lotz J, Wronski TJ, Lane NE. Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats. Osteoporos Int. 2005 Dec; 16(12):1939-47. PMID: 16086094.
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    60. Offley SC, Guo TZ, Wei T, Clark JD, Vogel H, Lindsey DP, Jacobs CR, Yao W, Lane NE, Kingery WS. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res. 2005 Feb; 20(2):257-67. PMID: 15647820.
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    61. Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res. 2005 Jan; 20(1):58-66. PMID: 15619670.
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    62. Buxton EC, Yao W, Lane NE. Changes in serum receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and interleukin-6 levels in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). J Clin Endocrinol Metab. 2004 Jul; 89(7):3332-6. PMID: 15240611.
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    63. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res. 2004 Feb; 19(2):224-34. PMID: 14969392.
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    64. Lane NE, Yao W, Kinney JH, Modin G, Balooch M, Wronski TJ. Both hPTH(1-34) and bFGF increase trabecular bone mass in osteopenic rats but they have different effects on trabecular bone architecture. J Bone Miner Res. 2003 Dec; 18(12):2105-15. PMID: 14672345.
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    65. Lane NE, Kumer J, Yao W, Breunig T, Wronski T, Modin G, Kinney JH. Basic fibroblast growth factor forms new trabeculae that physically connect with pre-existing trabeculae, and this new bone is maintained with an anti-resorptive agent and enhanced with an anabolic agent in an osteopenic rat model. Osteoporos Int. 2003 Jun; 14(5):374-82. PMID: 12768279.
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    66. Ma YL, Bryant HU, Zeng Q, Schmidt A, Hoover J, Cole HW, Yao W, Jee WS, Sato M. New bone formation with teriparatide [human parathyroid hormone-(1-34)] is not retarded by long-term pretreatment with alendronate, estrogen, or raloxifene in ovariectomized rats. Endocrinology. 2003 May; 144(5):2008-15. PMID: 12697709.
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    67. Li CY, Jee WS, Chen JL, Mo A, Setterberg RB, Su M, Tian XY, Ling YF, Yao W. Estrogen and "exercise" have a synergistic effect in preventing bone loss in the lumbar vertebra and femoral neck of the ovariectomized rat. Calcif Tissue Int. 2003 Jan; 72(1):42-9. PMID: 12370795.
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    68. Mo A, Yao W, Li C, Tian X, Su M, Ling Y, Zhang Q, Setterberg RB, Jee WS. Bipedal stance exercise and prostaglandin E2 (PGE2) and its synergistic effect in increasing bone mass and in lowering the PGE2 dose required to prevent ovariectomized-induced cancellous bone loss in aged rats. Bone. 2002 Sep; 31(3):402-6. PMID: 12231413.
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    69. Soper DL, Milbank JB, Mieling GE, Dirr MJ, Kende AS, Cooper R, Jee WS, Yao W, Chen JL, Bodman M, Lundy MW, De B, Stella ME, Ebetino FH, Wang Y, deLong MA, Wos JA. Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. J Med Chem. 2001 Nov 22; 44(24):4157-69. PMID: 11708917.
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    70. Chen JL, Yao W, Frost HM, Li CY, Setterberg RB, Jee WS. Bipedal stance exercise enhances antiresorption effects of estrogen and counteracts its inhibitory effect on bone formation in sham and ovariectomized rats. Bone. 2001 Aug; 29(2):126-33. PMID: 11502473.
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    71. Zhou H, Ma YF, Yao W, Cui L, Setterberg R, Liang CT, Jee WS. Lumbar vertebral cancellous bone is capable of responding to PGE2 treatment by stimulating both modeling and remodeling-dependent bone gain in aged male rats. Calcif Tissue Int. 2001 Mar; 68(3):179-84. PMID: 11351502.
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    72. Cui L, Ma YF, Yao W, Zhou H, Setterberg RB, Liang TC, Jee WS. Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain. J Bone Miner Metab. 2001; 19(1):29-37. PMID: 11156470.
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    73. Yao W, Jee WS, Chen J, Tam CS, Setterberg RB, Frost HM. Erect bipedal stance exercise partially prevents orchidectomy-induced bone loss in the lumbar vertebrae of rats. Bone. 2000 Nov; 27(5):667-75. PMID: 11062354.
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    74. Yao W, Jee WS, Chen J, Liu H, Tam CS, Cui L, Zhou H, Setterberg RB, Frost HM. Making rats rise to erect bipedal stance for feeding partially prevented orchidectomy-induced bone loss and added bone to intact rats. J Bone Miner Res. 2000 Jun; 15(6):1158-68. PMID: 10841185.
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    75. Yao W, Jee WS, Zhou H, Lu J, Cui L, Setterberg R, Liang T, Ma Y. Anabolic effect of prostaglandin E2 on cortical bone of aged male rats comes mainly from modeling-dependent bone gain. Bone. 1999 Dec; 25(6):697-702. PMID: 10593415.
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