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Wenbin Deng

Title(s)Professor, Biochemistry and Molecular Medicine
SchoolUniversity of California, Davis
Phone916-453-2287
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wen H, Xiao W, Biswas S, Cong ZQ, Liu XM, Lam KS, Liao YH, Deng W. Alginate Hydrogel Modified with a Ligand Interacting with a3ß1 Integrin Receptor Promotes the Differentiation of 3D Neural Spheroids toward Oligodendrocytes in Vitro. ACS Appl Mater Interfaces. 2019 Feb 13; 11(6):5821-5833. PMID: 30645095.
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    2. Thai PN, Daugherty DJ, Frederich BJ, Lu X, Deng W, Bers DM, Dedkova EN, Schaefer S. Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Sci Rep. 2018 11 01; 8(1):16213. PMID: 30385779.
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    3. Mokhtarzadeh Khanghahi A, Satarian L, Deng W, Baharvand H, Javan M. In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis. PLoS One. 2018; 13(9):e0203785. PMID: 30212518.
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    4. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Rep. 2018 07 10; 24(2):355-365. PMID: 29996097.
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    5. Chung SH, Biswas S, Sohn J, Jiang P, Dehghan S, Marzban H, Deng W. The p38a MAPK Deletion in Oligodendroglia does not Attenuate Myelination Defects in a Mouse Model of Periventricular Leukomalacia. Neuroscience. 2018 08 21; 386:175-181. PMID: 29966722.
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    6. Cheng XY, Li SY, Mao CJ, Wang MX, Chen J, Wang F, Wang GH, Deng WB, Li XK, Liu CF. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. 2018 02 10; 371:288-295. PMID: 29196028.
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    7. Tian Z, Zhao Q, Biswas S, Deng W. Methods of reactivation and reprogramming of neural stem cells for neural repair. Methods. 2018 01 15; 133:3-20. PMID: 28864354.
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    8. Xiao J, Yang R, Biswas S, Zhu Y, Qin X, Zhang M, Zhai L, Luo Y, He X, Mao C, Deng W. Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis. Mol Neurobiol. 2018 Apr; 55(4):3152-3171. PMID: 28466274.
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    9. Zhang M, Biswas S, Deng W, Yu H. The Crystal Structure of Monovalent Streptavidin. Sci Rep. 2016 12 21; 6:35915. PMID: 28000673.
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    10. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology. Stem Cells. 2016 11; 34(11):2670-2680. PMID: 27434649.
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    11. Zhang M, Biswas S, Qin X, Gong W, Deng W, Yu H. Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? Cancer Med. 2016 08; 5(8):2048-60. PMID: 27228302.
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    12. Jiang P, Chen C, Liu XB, Pleasure DE, Liu Y, Deng W. Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion. Cell Rep. 2016 05 10; 15(6):1303-15. PMID: 27134175.
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    13. Tian Z, Guo F, Biswas S, Deng W. Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. Int J Mol Sci. 2016 Apr 20; 17(4). PMID: 27104529.
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    14. Daugherty DJ, Chechneva O, Mayrhofer F, Deng W. The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci Rep. 2016 Mar 01; 6:22556. PMID: 26925573.
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    15. Zhai L, Wang L, Teng F, Zhou L, Zhang W, Xiao J, Liu Y, Deng W. Argonaute and Argonaute-Bound Small RNAs in Stem Cells. Int J Mol Sci. 2016 Feb 04; 17(2):208. PMID: 26861290.
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    16. Liu XB, Shen Y, Pleasure DE, Deng W. The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci. 2016 Jan 05; 17:2. PMID: 26733225.
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    17. Li S, Xue H, Wu J, Rao MS, Kim DH, Deng W, Liu Y. Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev. 2015 Dec 15; 24(24):2925-42. PMID: 26414932.
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    18. Chen C, Chan A, Wen H, Chung SH, Deng W, Jiang P. Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases. Trends Mol Med. 2015 Nov; 21(11):715-729. PMID: 26443123.
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    19. Liu Y, Deng W. Reverse engineering human neurodegenerative disease using pluripotent stem cell technology. Brain Res. 2016 May 01; 1638(Pt A):30-41. PMID: 26423934.
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    20. Xiao J, Liu W, Chen Y, Deng W. Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. J Neuroinflammation. 2015 Jun 12; 12:117. PMID: 26068104.
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    21. Zhang M, Shao J, Xiao J, Deng W, Yu H. A novel approach to make homogeneous protease-stable monovalent streptavidin. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):1059-63. PMID: 26074145.
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    22. Chung SH, Biswas S, Selvaraj V, Liu XB, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W. The p38a mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS. Cell Death Dis. 2015 May 07; 6:e1748. PMID: 25950478.
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    23. Xiao J, Yang R, Biswas S, Qin X, Zhang M, Deng W. Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. Int J Mol Sci. 2015 Apr 24; 16(5):9283-302. PMID: 25918935.
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    24. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/ß-catenin signaling. J Neurosci. 2015 Mar 25; 35(12):5007-22. PMID: 25810530.
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    25. Xiao J, Yang R, Yang L, Fan X, Liu W, Deng W. Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. Sci Rep. 2015 Mar 12; 5:9022. PMID: 25762107.
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    26. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 04; 35(9):3756-63. PMID: 25740506.
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    27. Lo U, Selvaraj V, Plane JM, Chechneva OV, Otsu K, Deng W. p38a (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci Rep. 2014 Dec 12; 4:7405. PMID: 25502009.
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    28. Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23; 5:e1481. PMID: 25341035.
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    29. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944.
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    30. Jiang P, Chen C, Liu XB, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li RA, Deng W. Generation and characterization of spiking and nonspiking oligodendroglial progenitor cells from embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2620-31. PMID: 23940003.
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    31. Li Y, Xiao K, Zhu W, Deng W, Lam KS. Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Adv Drug Deliv Rev. 2014 Feb; 66:58-73. PMID: 24060922.
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    32. Daugherty DJ, Selvaraj V, Chechneva OV, Liu XB, Pleasure DE, Deng W. A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med. 2013 Jun; 5(6):891-903. PMID: 23681668.
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    33. Chung SH, Guo F, Jiang P, Pleasure DE, Deng W. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death Dis. 2013 Mar 14; 4:e546. PMID: 23492777.
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    34. Liu XB, Shen Y, Plane JM, Deng W. Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury. Neurosci Bull. 2013 Apr; 29(2):229-38. PMID: 23456565.
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    35. Liu W, Deng Y, Liu Y, Gong W, Deng W. Stem cell models for drug discovery and toxicology studies. J Biochem Mol Toxicol. 2013 Jan; 27(1):17-27. PMID: 23293059.
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    36. Jiang P, Chen C, Wang R, Chechneva OV, Chung SH, Rao MS, Pleasure DE, Liu Y, Zhang Q, Deng W. hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. Nat Commun. 2013; 4:2196. PMID: 23880652.
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    37. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D. PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 2012 Aug 29; 32(35):12152-64. PMID: 22933798.
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    38. Chen C, Daugherty D, Jiang P, Deng W. Oligodendrocyte progenitor cells derived from mouse embryonic stem cells give rise to type-1 and type-2 astrocytes in vitro. Neurosci Lett. 2012 Aug 15; 523(2):180-5. PMID: 22781495.
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    39. Plane JM, Grossenbacher SK, Deng W. PARP-1 deletion promotes subventricular zone neural stem cells toward a glial fate. J Neurosci Res. 2012 Aug; 90(8):1489-506. PMID: 22431411.
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    40. Selvaraj V, Jiang P, Chechneva O, Lo UG, Deng W. Differentiating human stem cells into neurons and glial cells for neural repair. Front Biosci (Landmark Ed). 2012 Jan 01; 17:65-89. PMID: 22201733.
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    41. Jantzie LL, Talos DM, Selip DB, An L, Jackson MC, Folkerth RD, Deng W, Jensen FE. Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia. Neuron Glia Biol. 2010 Nov; 6(4):277-88. PMID: 22169210.
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    42. Calafiore M, Copani A, Deng W. DNA polymerase-ß mediates the neurogenic effect of ß-amyloid protein in cultured subventricular zone neurospheres. J Neurosci Res. 2012 Mar; 90(3):559-67. PMID: 22057776.
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    43. Zhang J, Calafiore M, Zeng Q, Zhang X, Huang Y, Li RA, Deng W, Zhao M. Electrically guiding migration of human induced pluripotent stem cells. Stem Cell Rev Rep. 2011 Nov; 7(4):987-96. PMID: 21373881.
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    44. Shen Y, Liu XB, Pleasure DE, Deng W. Axon-glia synapses are highly vulnerable to white matter injury in the developing brain. J Neurosci Res. 2012 Jan; 90(1):105-21. PMID: 21812016.
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    45. Chechneva OV, Mayrhofer F, Daugherty DJ, Pleasure DE, Hong JS, Deng W. Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. Neurobiol Dis. 2011 Oct; 44(1):63-72. PMID: 21704706.
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    46. Soundarapandian MM, Selvaraj V, Lo UG, Golub MS, Feldman DH, Pleasure DE, Deng W. Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Sci Rep. 2011; 1:2. PMID: 22355521.
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    47. Lo KY, Sun YS, Landry JP, Zhu X, Deng W. Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy. Biotechniques. 2011 Jun; 50(6):381-8. PMID: 21781038.
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    48. Wang YZ, Plane JM, Jiang P, Zhou CJ, Deng W. Concise review: Quiescent and active states of endogenous adult neural stem cells: identification and characterization. Stem Cells. 2011 Jun; 29(6):907-12. PMID: 21557389.
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    49. Liu W, Shen Y, Plane JM, Pleasure DE, Deng W. Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. Exp Neurol. 2011 Aug; 230(2):227-39. PMID: 21596035.
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    50. Liu Y, Jiang P, Deng W. OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation. Nat Protoc. 2011 May; 6(5):640-55. PMID: 21527921.
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    51. Chung SH, Calafiore M, Plane JM, Pleasure DE, Deng W. Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiol Dis. 2011 Feb; 41(2):445-57. PMID: 20974255.
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    52. Plane JM, Shen Y, Pleasure DE, Deng W. Prospects for minocycline neuroprotection. Arch Neurol. 2010 Dec; 67(12):1442-8. PMID: 20697034.
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    53. Deng W. Exploiting pluripotency for therapeutic gain. Panminerva Med. 2010 Jun; 52(2):167-73. PMID: 20517198.
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    54. Jiang P, Selvaraj V, Deng W. Differentiation of embryonic stem cells into oligodendrocyte precursors. J Vis Exp. 2010 May 19; (39). PMID: 20489683.
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    55. Shen Y, Plane JM, Deng W. Mouse models of periventricular leukomalacia. J Vis Exp. 2010 May 18; (39). PMID: 20485263.
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    56. Deng W. Neurobiology of injury to the developing brain. Nat Rev Neurol. 2010 Jun; 6(6):328-36. PMID: 20479779.
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    57. Deng W. AID in reprogramming: quick and efficient: identification of a key enzyme called AID, and its activity in DNA demethylation, may help to overcome a pivotal epigenetic barrier in reprogramming somatic cells toward pluripotency. Bioessays. 2010 May; 32(5):385-7. PMID: 20394066.
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    58. Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol. 2010 Apr; 67(4):526-33. PMID: 20437588.
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    59. Deng W. Induced pluripotent stem cells: paths to new medicines. A catalyst for disease modelling, drug discovery and regenerative therapy. EMBO Rep. 2010 Mar; 11(3):161-5. PMID: 20168328.
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    60. Selvaraj V, Plane JM, Williams AJ, Deng W. Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends Biotechnol. 2010 Apr; 28(4):214-23. PMID: 20149468.
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    61. Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA. Electrophysiological properties of human induced pluripotent stem cells. Am J Physiol Cell Physiol. 2010 Mar; 298(3):C486-95. PMID: 19955484.
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    62. Deng W, Xu Y. Genome integrity: linking pluripotency and tumorgenicity. Trends Genet. 2009 Oct; 25(10):425-7. PMID: 19801173.
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    63. Deng W. PARylation: strengthening the connection between cancer and pluripotency. Cell Stem Cell. 2009 Oct 02; 5(4):349-50. PMID: 19796612.
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    64. Selvaraj V, Soundarapandian MM, Chechneva O, Williams AJ, Sidorov MK, Soulika AM, Pleasure DE, Deng W. PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. J Biol Chem. 2009 Sep 18; 284(38):26070-84. PMID: 19628872.
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    65. Deng W, Pleasure J, Pleasure D. Progress in periventricular leukomalacia. Arch Neurol. 2008 Oct; 65(10):1291-5. PMID: 18852342.
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    66. Deng W, Neve RL, Rosenberg PA, Volpe JJ, Jensen FE. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity. J Biol Chem. 2006 Nov 24; 281(47):36004-11. PMID: 16990276.
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    67. Deng W, Yue Q, Rosenberg PA, Volpe JJ, Jensen FE. Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function. J Neurochem. 2006 Jul; 98(1):213-22. PMID: 16606353.
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    68. Deng W, Wang H, Rosenberg PA, Volpe JJ, Jensen FE. Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7751-6. PMID: 15136737.
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    69. Follett PL, Deng W, Dai W, Talos DM, Massillon LJ, Rosenberg PA, Volpe JJ, Jensen FE. Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J Neurosci. 2004 May 05; 24(18):4412-20. PMID: 15128855.
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    70. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6801-6. PMID: 12743362.
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    71. Deng W, Poretz RD. Oligodendroglia in developmental neurotoxicity. Neurotoxicology. 2003 Mar; 24(2):161-78. PMID: 12606289.
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    72. Deng W, Poretz RD. Protein kinase C activation is required for the lead-induced inhibition of proliferation and differentiation of cultured oligodendroglial progenitor cells. Brain Res. 2002 Mar 01; 929(1):87-95. PMID: 11852034.
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    73. Deng W, Poretz RD. Lead alters the developmental profile of the galactolipid metabolic enzymes in cultured oligodendrocyte lineage cells. Neurotoxicology. 2001 Aug; 22(4):429-37. PMID: 11577801.
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    74. Deng W, McKinnon RD, Poretz RD. Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol Appl Pharmacol. 2001 Aug 01; 174(3):235-44. PMID: 11485384.
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    75. Deng W, Poretz RD. Lead exposure affects levels of galactolipid metabolic enzymes in the developing rat brain. Toxicol Appl Pharmacol. 2001 Apr 15; 172(2):98-107. PMID: 11298496.
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    76. Poretz RD, Yang A, Deng W, Manowitz P. The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts. Neurotoxicology. 2000 Jun; 21(3):379-87. PMID: 10894127.
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