Wendy M Campana

Title(s)Professor, MED: Cell Biology & Human Anat
SchoolSchool of Medicine
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    Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy
    NIH R01DE033674Sep 20, 2024 - Aug 31, 2027
    Role: Co-Principal Investigator
    Targeting LRP1 in Neuroinflammation and Neuropathic Pain
    NIH I01BX006386Feb 1, 2024 - Jan 31, 2028
    Role: Principal Investigator
    Regulation of Schwann Cell Mitochondria Homeostasis in Painful Peripheral Neuropathy
    NIH R21NS135430Sep 18, 2023 - Aug 31, 2025
    Role: Principal Investigator
    Targeting Schwann cell exosomes for treating neuropathic pain
    NIH I01RX003363Oct 1, 2020 - Sep 30, 2024
    Role: Principal Investigator
    Identifying novel proteins in injured nerves that promote functional regeneration
    NIH I01RX002484Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    Schwann Cell NMDA Receptor in PNS Injury
    NIH R01NS097590Feb 1, 2017 - Jan 31, 2021
    Role: Co-Principal Investigator
    LRP-1 is a multifunctional regulator during peripheral nerve injury and pain.
    NIH R01NS057456Jan 15, 2008 - Dec 31, 2013
    Role: Principal Investigator
    Epo-dependent JAK2 Signaling in Painful Neuropathy
    NIH R01NS041983Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity. J Headache Pain. 2025 Dec 22; 26(1):290. Gong Z, Zhang M, Liu N, Asam K, Martellucci S, Aouizerat B, Campana W, Ye Y. PMID: 41430102; PMCID: PMC12750843.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. The low-density lipoprotein receptor-related protein-1 (LRP1) in Schwann cells controls mitochondria homeostasis in peripheral nerves. Prog Neurobiol. 2025 08; 251:102796. Martellucci S, Heredia M, Wang Z, Whisenant T, Strickland DK, Sanchez R, Arai T, Zhang M, Wang H, Gong Z, Asam K, Aouizerat BE, Pekkurnaz G, Ye Y, Campana WM. PMID: 40541732.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9. Biochemistry. 2024 03 19; 63(6):725-732. Kim JH, Shivkumar A, Norimoto M, Castro Lingl S, Seitz C, Amaro RE, Gonias SL, Yang J, Campana WM. PMID: 38450612.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities. Glia. 2024 05; 72(5):916-937. Martellucci S, Flütsch A, Carter M, Norimoto M, Pizzo D, Mantuano E, Sadri M, Wang Z, Chillin-Fuentes D, Rosenthal SB, Azmoon P, Gonias SL, Campana WM. PMID: 38372375; PMCID: PMC13189221.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Schwann cell extracellular vesicles: judging a book by its cover. Neural Regen Res. 2023 Feb; 18(2):325-326. Gonias SL, Campana WM. PMID: 35900418; PMCID: PMC9396481.
      View in: PubMed   Mentions: 1  
    6. Advances in Head and Neck Cancer Pain. J Dent Res. 2022 08; 101(9):1025-1033. Ye Y, Jensen DD, Viet CT, Pan HL, Campana WM, Amit M, Boada MD. PMID: 35416080; PMCID: PMC9305840.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    7. Brain organoids, consciousness, ethics and moral status. Semin Cell Dev Biol. 2023 07 30; 144:97-102. Jeziorski J, Brandt R, Evans JH, Campana W, Kalichman M, Thompson E, Goldstein L, Koch C, Muotri AR. PMID: 35339359.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    8. Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system. J Biol Chem. 2022 03; 298(3):101642. Gonias SL, Banki MA, Azmoon P, Romero HK, Sigurdson CJ, Mantuano E, Campana WM. PMID: 35090893; PMCID: PMC8861162.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. α1-Antitrypsin derived SP16 peptide demonstrates efficacy in rodent models of acute and neuropathic pain. FASEB J. 2022 01; 36(1):e22093. Wang Z, Martellucci S, Van Enoo A, Austin D, Gelber C, Campana WM. PMID: 34888951; PMCID: PMC8669735.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. J Immunol. 2022 01 01; 208(1):85-96. Mantuano E, Azmoon P, Banki MA, Sigurdson CJ, Campana WM, Gonias SL. PMID: 34810220; PMCID: PMC8702456.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy. Glia. 2022 02; 70(2):256-272. Sadri M, Hirosawa N, Le J, Romero H, Martellucci S, Kwon HJ, Pizzo D, Ohtori S, Gonias SL, Campana WM. PMID: 34559433; PMCID: PMC10656730.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    12. Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion. Pain. 2020 11; 161(11):2592-2602. Salvo E, Campana WM, Scheff NN, Nguyen TH, Jeong SH, Wall I, Wu AK, Zhang S, Kim H, Bhattacharya A, Janal MN, Liu C, Albertson DG, Schmidt BL, Dolan JC, Schmidt RE, Boada MD, Ye Y. PMID: 32658150; PMCID: PMC7572698.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    13. Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing. J Neurosci. 2020 11 18; 40(47):9121-9136. Brifault C, Romero H, Van-Enoo A, Pizzo D, Azmoon P, Kwon H, Nasamran C, Gonias SL, Campana WM. PMID: 33051351; PMCID: PMC7672997.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. Sci Rep. 2019 12 17; 9(1):19291. Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM. PMID: 31848365; PMCID: PMC6917728.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. Front Neurosci. 2019; 13:1005. Winston CN, Romero HK, Ellisman M, Nauss S, Julovich DA, Conger T, Hall JR, Campana W, O'Bryant SE, Nievergelt CM, Baker DG, Risbrough VB, Rissman RA. PMID: 31680797; PMCID: PMC6797846.
      View in: PubMed   Mentions: 65  
    16. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. 2019 06; 67(6):1210-1224. Brifault C, Kwon H, Campana WM, Gonias SL. PMID: 30746765; PMCID: PMC6462253.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    17. PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 07 26; 131(14). Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PMID: 29930084; PMCID: PMC6080607.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia. 2018 08; 66(8):1577-1590. Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM. PMID: 29520865; PMCID: PMC6129445.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    19. Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit. J Biomed Mater Res A. 2017 Dec; 105(12):3392-3399. Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28804998; PMCID: PMC6611669.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    20. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. PMID: 28684538; PMCID: PMC5600142.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    21. Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords. Tissue Eng Part A. 2017 05; 23(9-10):415-425. Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. PMID: 28107810; PMCID: PMC5444512.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 04; 31(4):1744-1755. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL. PMID: 28073836; PMCID: PMC5349802.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. PMID: 27824728; PMCID: PMC5123743.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    24. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM. PMID: 26808661; PMCID: PMC13189222.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    25. Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. PLoS One. 2013; 8(9):e75497. Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM. PMID: 24086544; PMCID: PMC3781060.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. Erythropoietin: not just about erythropoiesis. Lancet. 2010 Jun 19; 375(9732):2142. Ghezzi P, Bernaudin M, Bernaudinb M, Bianchi R, Bianchic R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C. PMID: 20609950; PMCID: PMC4894326.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    27. Schwann cells: activated peripheral glia and their role in neuropathic pain. Brain Behav Immun. 2007 Jul; 21(5):522-7. Campana WM. PMID: 17321718; PMCID: PMC2219463.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    28. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. PMID: 12950462.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    29. Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury. FASEB J. 2001 Aug; 15(10):1804-6. Campana WM, Myers RR. PMID: 11481236.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    30. Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury. Muscle Nerve. 2001 Jun; 24(6):799-808. Rende M, Brizi E, Donato R, Provenzano C, Bruno R, Mizisin AP, Garrett RS, Calcutt NA, Campana WM, O'Brien JS. PMID: 11360264.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. A retro-inverso Prosaptide D5 promotes a myelination process in developing rats. Brain Res Dev Brain Res. 2001 May 31; 128(1):73-6. Hiraiwa M, Campana WM, Wang CY, Otero DA, O'Brien JS. PMID: 11356264.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. FASEB J. 2001 Feb; 15(2):467-74. Misasi R, Sorice M, Di Marzio L, Campana WM, Molinari S, Cifone MG, Pavan A, Pontieri GM, O'Brien JS. PMID: 11156962.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. Prosaposin-derived peptides enhanced sprouting of sensory neurons in vitro and induced sprouting at motor endplates in vivo. J Peripher Nerv Syst. 2000 Sep; 5(3):126-30. Campana WM, Mohiuddin L, Misasi R, O'Brien JS, Calcutt NA. PMID: 11442168.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in Schwann cells. J Neurosci Res. 1999 Aug 01; 57(3):332-41. Campana WM, Darin SJ, O'Brien JS. PMID: 10412024.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    35. Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats. J Neuropathol Exp Neurol. 1999 Jun; 58(6):628-36. Calcutt NA, Campana WM, Eskeland NL, Mohiuddin L, Dines KC, Mizisin AP, O'Brien JS. PMID: 10374753.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    36. Prosaposin: a myelinotrophic protein that promotes expression of myelin constituents and is secreted after nerve injury. Glia. 1999 Jun; 26(4):353-60. Hiraiwa M, Campana WM, Mizisin AP, Mohiuddin L, O'Brien JS. PMID: 10383054.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    37. Secretion of prosaposin, a multifunctional protein, by breast cancer cells. Biochim Biophys Acta. 1999 May 24; 1427(3):392-400. Campana WM, O'Brien JS, Hiraiwa M, Patton S. PMID: 10350655.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Necrotizing myopathy induced by overexpression of interferon-gamma in transgenic mice. Muscle Nerve. 1999 Feb; 22(2):156-65. Shelton GD, Calcutt NA, Garrett RS, Gu D, Sarvetnick N, Campana WM, Powell HC. PMID: 10024128.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. Prosaptide prevents paclitaxel neurotoxicity. Neurotoxicology. 1998 Apr; 19(2):237-44. Campana WM, Eskeland N, Calcutt NA, Misasi R, Myers RR, O'Brien JS. PMID: 9553960.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    40. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998 Mar; 12(3):307-14. Campana WM, Hiraiwa M, O'Brien JS. PMID: 9506474.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    41. Identification of a neurotrophic sequence in erythropoietin. Int J Mol Med. 1998 Jan; 1(1):235-41. Campana WM, Misasi R, O'Brien JS. PMID: 9852225.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    42. Prosaposin receptor: evidence for a G-protein-associated receptor. Biochem Biophys Res Commun. 1997 Nov 17; 240(2):415-8. Hiraiwa M, Campana WM, Martin BM, O'Brien JS. PMID: 9388493.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    43. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4778-81. Hiraiwa M, Taylor EM, Campana WM, Darin SJ, O'Brien JS. PMID: 9114068; PMCID: PMC20801.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    44. Induction of MAPK phosphorylation by prosaposin and prosaptide in PC12 cells. Biochem Biophys Res Commun. 1996 Dec 24; 229(3):706-12. Campana WM, Hiraiwa M, Addison KC, O'Brien JS. PMID: 8954961.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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