Helene G Margolis

Title(s)Associate Adjunct Professor, General Medicine, Geriatrics, and Bioethics
SchoolSchool of Medicine
Address4150 V Street, Ste. 2400
CA 95817
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    Collapse Education and Training
    Southampton College, Long Island University, Southampton, NYBA06/1976Marine Sciences/General Biology
    City College of New York, New York, NY06/1979Pre-Medicine/-Veterinary Studies
    California State University, Sacramento , Sacramento, CAMA05/1985Immunology/Biology
    University of California, Davis, School of Medicine, Davis, CAPhD12/2003Epidemiology

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    Collapse Overview
    Dr. Margolis is a chronic disease and environmental epidemiologist, nationally and internationally recognized for her expertise and research on health impacts of climate change-mediated stressors, with a focus on implications for clinical practice and population health, as well as her expertise on children’s environmental health. She has particular expertise on the health effects of heat stress and air pollution, and the pathophysiology/mechanisms and influence of environmental factors on the natural history of chronic diseases (respiratory, cardiovascular, metabolic, immunologic, and neurologic). Prior to and overlapping her UCD Faculty appointment, Dr. Margolis had a distinguished 20-year career as a California State government-based scientist and policy analyst, holding a number of leadership positions. The mission of her current research and its translation is to reduce health and social inequities and tackle ethical issues in local-to-global health, and the challenges of healthcare access that are long-standing and are now being amplified by climate change. Central to the research is conceptualization and implementation of multiple determinants of health/health disparities models that holistically consider biological, environmental, behavioral, and socioeconomic factors at individual- and community-levels and assess vulnerability across the life-span. Dr. Margolis is committed to translating complex interdisciplinary science to actionable knowledge for diverse professional and lay audiences, especially community groups; she shares that knowledge through numerous invited lectures and community engagement.

    Dr. Margolis is a dedicated mentor and educator, with a special interest in the integration of clinically-relevant and population health-relevant climate change topics into medical school curricula. Key among her teaching objectives is to foster students’ skills and comfort with systems thinking and collaborating within transdisciplinary/transprofessional teams.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Comparison of PM2.5 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women's Health Initiative Memory Study (WHIMS). Environ Health Perspect. 2024 Jan; 132(1):17003. Power MC, Bennett EE, Lynch KM, Stewart JD, Xu X, Park ES, Smith RL, Vizuete W, Margolis HG, Casanova R, Wallace R, Sheppard L, Ying Q, Serre ML, Szpiro AA, Chen JC, Liao D, Wellenius GA, van Donkelaar A, Yanosky JD, Whitsel E. PMID: 38226465; PMCID: PMC10790222.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Short-term Air Pollution Levels and Blood Pressure in Older Women. Epidemiology. 2023 03 01; 34(2):271-281. Wen T, Liao D, Wellenius GA, Whitsel EA, Margolis HG, Tinker LF, Stewart JD, Kong L, Yanosky JD. PMID: 36722810; PMCID: PMC9891284.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    3. Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children. J Expo Sci Environ Epidemiol. 2022 07; 32(4):530-537. Zhang AL, Balmes JR, Lutzker L, Mann JK, Margolis HG, Tyner T, Holland N, Noth EM, Lurmann F, Hammond SK, Holm SM. PMID: 34417545; PMCID: PMC8858324.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    4. Greening the International Society for Environmental Epidemiology. Epidemiology. 2021 07 01; 32(4):466-468. Pascal M, Margolis HG, Etzel RA. PMID: 33788794.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children. Environ Res. 2021 04; 195:110870. Mann JK, Lutzker L, Holm SM, Margolis HG, Neophytou AM, Eisen EA, Costello S, Tyner T, Holland N, Tindula G, Prunicki M, Nadeau K, Noth EM, Lurmann F, Hammond SK, Balmes JR. PMID: 33587949; PMCID: PMC8520413.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    6. Ambient air pollution and lung cancer risk among never-smokers in the Women's Health Initiative. Environ Epidemiol. 2019 Dec; 3(6):e076. Gowda SN, DeRoos AJ, Hunt RP, Gassett AJ, Mirabelli MC, Bird CE, Margolis HG, Lane D, Bonner MR, Anderson G, Whitsel EA, Kaufman JD, Bhatti P. PMID: 33778344; PMCID: PMC7939397.
      View in: PubMed   Mentions: 7  
    7. Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. Environ Int. 2018 07; 116:239-247. Wong JYY, Margolis HG, Machiela M, Zhou W, Odden MC, Psaty BM, Robbins J, Jones RR, Rotter JI, Chanock SJ, Rothman N, Lan Q, Lee JS. PMID: 29698900; PMCID: PMC5971001.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsPHPublic Health
    8. Residential proximity to major roadways and incident hypertension in post-menopausal women. Environ Res. 2015 Oct; 142:522-8. Kingsley SL, Eliot MN, Whitsel EA, Wang Y, Coull BA, Hou L, Margolis HG, Margolis KL, Mu L, Wu WC, Johnson KC, Allison MA, Manson JE, Eaton CB, Wellenius GA. PMID: 26282224; PMCID: PMC4609282.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansPHPublic Health
    9. Heat Waves and Rising Temperatures: Human Health Impacts and the Determinants of Vulnerability. . 2014 Jan 1; 85-120. Margolis MH. .
      View in: Publisher Site   Mentions:
    10. Correlation between aerial insecticide spraying to interrupt west nile virus transmission and emergency department visits in Sacramento County, California. Public Health Rep. 2013 May-Jun; 128(3):221-30. Geraghty EM, Margolis HG, Kjemtrup A, Reisen W, Franks P. PMID: 23633737; PMCID: PMC3610074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    11. Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study. Am J Epidemiol. 2012 Aug 01; 176(3):214-23. Eckel SP, Louis TA, Chaves PH, Fried LP, Margolis AH. PMID: 22811494; PMCID: PMC3491964.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansPHPublic Health
    12. An official American Thoracic Society workshop report: Climate change and human health. Proc Am Thorac Soc. 2012 Mar; 9(1):3-8. Pinkerton KE, Rom WN, Akpinar-Elci M, Balmes JR, Bayram H, Brandli O, Hollingsworth JW, Kinney PL, Margolis HG, Martin WJ, Sasser EN, Smith KR, Takaro TK, American Thoracic Society Environmental Health Policy Committee. PMID: 22421581; PMCID: PMC5821002.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    13. Evaluation of a heat vulnerability index on abnormally hot days: an environmental public health tracking study. Environ Health Perspect. 2012 May; 120(5):715-20. Reid CE, Mann JK, Alfasso R, English PB, King GC, Lincoln RA, Margolis HG, Rubado DJ, Sabato JE, West NL, Woods B, Navarro KM, Balmes JR. PMID: 22538066; PMCID: PMC3346770.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansPHPublic Health
    14. Ambient particulate matter air pollution and venous thromboembolism in the Women's Health Initiative Hormone Therapy trials. Environ Health Perspect. 2011 Mar; 119(3):326-31. Shih RA, Griffin BA, Salkowski N, Jewell A, Eibner C, Bird CE, Liao D, Cushman M, Margolis HG, Eaton CB, Whitsel EA. PMID: 21036692; PMCID: PMC3059994.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    15. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environ Health Perspect. 2010 Oct; 118(10):1497-502. Mann JK, Balmes JR, Bruckner TA, Mortimer KM, Margolis HG, Pratt B, Hammond SK, Lurmann FW, Tager IB. PMID: 20570778; PMCID: PMC2957935.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    16. Altered pulmonary function in children with asthma associated with highway traffic near residence. Int J Environ Health Res. 2009 Apr; 19(2):139-55. Margolis HG, Mann JK, Lurmann FW, Mortimer KM, Balmes JR, Hammond SK, Tager IB. PMID: 19370464.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansPHPublic Health
    17. The 2006 California heat wave: impacts on hospitalizations and emergency department visits. Environ Health Perspect. 2009 Jan; 117(1):61-7. Knowlton K, Rotkin-Ellman M, King G, Margolis HG, Smith D, Solomon G, Trent R, English P. PMID: 19165388; PMCID: PMC2627866.
      View in: PubMed   Mentions: 223     Fields:    
    18. Inflammatory markers and longitudinal lung function decline in the elderly. Am J Epidemiol. 2008 Sep 15; 168(6):602-10. Jiang R, Burke GL, Enright PL, Newman AB, Margolis HG, Cushman M, Tracy RP, Wang Y, Kronmal RA, Barr RG. PMID: 18687665; PMCID: PMC2727196.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    19. Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study. Environ Health Perspect. 2005 Nov; 113(11):1638-44. Salam MT, Millstein J, Li YF, Lurmann FW, Margolis HG, Gilliland FD. PMID: 16263524; PMCID: PMC1310931.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansPHPublic Health
    20. Mode of delivery is associated with asthma and allergy occurrences in children. Ann Epidemiol. 2006 May; 16(5):341-6. Salam MT, Margolis HG, McConnell R, McGregor JA, Avol EL, Gilliland FD. PMID: 16242961.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    21. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004 Sep 09; 351(11):1057-67. Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. PMID: 15356303.
      View in: PubMed   Mentions: 369     Fields:    Translation:HumansPHPublic Health
    22. Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. PMID: 12091175.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansPHPublic Health
    23. Indoor risk factors for asthma in a prospective study of adolescents. Epidemiology. 2002 May; 13(3):288-95. McConnell R, Berhane K, Gilliland F, Islam T, Gauderman WJ, London SJ, Avol E, Rappaport EB, Margolis HG, Peters JM. PMID: 11964930.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsPHPublic Health
    24. Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002 Feb 02; 359(9304):386-91. McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. PMID: 11844508.
      View in: PubMed   Mentions: 178     Fields:    Translation:Humans
    25. Dietary magnesium, potassium, sodium, and children's lung function. Am J Epidemiol. 2002 Jan 15; 155(2):125-31. Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. PMID: 11790675.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    26. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology. 2001 Jan; 12(1):43-54. Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. PMID: 11138819.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansPHPublic Health
    27. Sex-specific effects of asthma on pulmonary function in children. Am J Respir Crit Care Med. 2000 Nov; 162(5):1723-30. Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. PMID: 11069803.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    28. Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1383-90. Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. PMID: 11029349.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansPHPublic Health
    29. Quality of spirometry test performance in children and adolescents : experience in a large field study. Chest. 2000 Sep; 118(3):665-71. Enright PL, Linn WS, Avol EL, Margolis HG, Gong H, Peters JM. PMID: 10988187.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    30. Air pollution and bronchitic symptoms in Southern California children with asthma. Environ Health Perspect. 1999 Sep; 107(9):757-60. McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. PMID: 10464077; PMCID: PMC1566453.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansPHPublic Health
    31. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med. 1999 Mar; 159(3):768-75. Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong H, Thomas DC. PMID: 10051249.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    32. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med. 1999 Mar; 159(3):760-7. Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong H, Thomas DC. PMID: 10051248.
      View in: PubMed   Mentions: 128     Fields:    Translation:Humans
    33. Acidic deposition in California: Findings from a program of monitoring and effects research. Water, Air, & Soil Pollution. 1995 Dec 1; 85(1):261-272. Takemoto TB, Croes CB, Brown BS, Motallebi MN, Westerdahl WF, Margolis MH, Cahill CB, Mueller MM, Holmes HJ. .
      View in: Publisher Site   Mentions:
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