Kazuhiro Shiozaki

Title(s)Professor, Microbiology and Molecular Genetics
SchoolCollege of Biological Sciences
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    Collapse Research 
    Collapse Research Activities and Funding
    Dissection of Stress Signaling Pathways to a MAP Kinase
    NIH R01GM059788Aug 1, 1999 - Aug 31, 2014
    Role: Principal Investigator

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    1. Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif. J Cell Sci. 2021 10 01; 134(19). Morozumi Y, Hishinuma A, Furusawa S, Sofyantoro F, Tatebe H, Shiozaki K. PMID: 34499159; PMCID: PMC8542387.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Neu1 deficiency induces abnormal emotional behavior in zebrafish. Sci Rep. 2021 06 29; 11(1):13477. Ikeda A, Komamizu M, Hayashi A, Yamasaki C, Okada K, Kawabe M, Komatsu M, Shiozaki K. PMID: 34188220; PMCID: PMC8241872.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    3. Multiplexed suppression of TOR complex 1 induces autophagy during starvation. Autophagy. 2021 07; 17(7):1794-1795. Fukuda T, Shiozaki K. PMID: 34085593; PMCID: PMC8354673.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Host lactosylceramide enhances Edwardsiella tarda infection. Cell Microbiol. 2021 09; 23(9):e13365. Oishi K, Morise M, Vo LK, Tran NT, Sahashi D, Ueda-Wakamatsu R, Nishimura W, Komatsu M, Shiozaki K. PMID: 33988901.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis. Biochimie. 2021 Jun; 185:105-116. Honda A, Hayasaka O, Mio K, Fujimura K, Kotani T, Komatsu M, Shiozaki K. PMID: 33746065.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides. 2021 Jun; 87:102136. Kawabe M, Hayashi A, Komatsu M, Inui A, Shiozaki K. PMID: 33721592.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase. Elife. 2021 02 03; 10. Fukuda T, Sofyantoro F, Tai YT, Chia KH, Matsuda T, Murase T, Morozumi Y, Tatebe H, Kanki T, Shiozaki K. PMID: 33534698; PMCID: PMC7857730.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Conserved and Divergent Mechanisms That Control TORC1 in Yeasts and Mammals. Genes (Basel). 2021 01 12; 12(1). Morozumi Y, Shiozaki K. PMID: 33445779; PMCID: PMC7828246.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Identification of novel fish sialidase genes responsible for KDN-cleaving activity. Glycoconj J. 2020 12; 37(6):745-753. Shiozaki K, Uezono K, Hirai G, Honda A, Minoda M, Wakata R. PMID: 32980954.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes. Biochem J. 2020 08 14; 477(15):2841-2857. Okada K, Takase R, Hamaoka Y, Honda A, Ikeda A, Hokazono Y, Maeda Y, Hayasaka O, Kotani T, Komatsu M, Shiozaki K. PMID: 32686823.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio). Sci Rep. 2020 04 03; 10(1):5913. Shiozaki K, Kawabe M, Karasuyama K, Kurachi T, Hayashi A, Ataka K, Iwai H, Takeno H, Hayasaka O, Kotani T, Komatsu M, Inui A. PMID: 32246073; PMCID: PMC7125123.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Novel Nile tilapia Neu1 sialidases: Molecular cloning and biochemical characterization of the sialidases Neu1a and Neu1b. Gene. 2020 Jun 05; 742:144538. Honda A, Chigwechokha PK, Takase R, Hayasaka O, Fujimura K, Kotani T, Komatsu M, Shiozaki K. PMID: 32184168.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge. Nat Commun. 2020 01 17; 11(1):370. Tatebe H, Lim CT, Konno H, Shiozaki K, Shinohara A, Uchihashi T, Furukohri A. PMID: 31953386; PMCID: PMC6969161.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan. Aging Cell. 2020 02; 19(2):e13068. Shetty M, Noguchi C, Wilson S, Martinez E, Shiozaki K, Sell C, Mell JC, Noguchi E. PMID: 31833215; PMCID: PMC6996946.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Regulation of triglyceride metabolism in medaka (Oryzias latipes) hepatocytes by Neu3a sialidase. Fish Physiol Biochem. 2020 Apr; 46(2):563-574. Oishi K, Miyazaki M, Takase R, Chigwechokha PK, Komatsu M, Shiozaki K. PMID: 31792756.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. Desialylation by Edwardsiella tarda is the initial step in the regulation of its invasiveness. Biochem J. 2019 11 15; 476(21):3183-3196. Vo LK, Tsuzuki T, Kamada-Futagami Y, Chigwechokha PK, Honda A, Oishi K, Komatsu M, Shiozaki K. PMID: 31654066.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Elucidation of the Interleukin 12 Production Mechanism during Intracellular Bacterial Infection in Amberjack, Seriola dumerili. Infect Immun. 2019 11; 87(11). Matsumoto M, Kubota T, Fujita S, Shiozaki K, Kishida S, Yamamoto A. PMID: 31501250; PMCID: PMC6803335.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast. J Cell Sci. 2019 10 10; 132(19). Morigasaki S, Chin LC, Hatano T, Emori M, Iwamoto M, Tatebe H, Shiozaki K. PMID: 31477575.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate. Sci Adv. 2019 06; 5(6):eaav0184. Candiracci J, Migeot V, Chionh YH, Bauer F, Brochier T, Russell B, Shiozaki K, Dedon P, Hermand D. PMID: 31223645; PMCID: PMC6584457.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    20. Green light irradiation during sex differentiation induces female-to-male sex reversal in the medaka Oryzias latipes. Sci Rep. 2019 02 20; 9(1):2383. Hayasaka O, Takeuchi Y, Shiozaki K, Anraku K, Kotani T. PMID: 30787482; PMCID: PMC6382872.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. Nutrient Signaling via the TORC1-Greatwall-PP2AB55δ Pathway Is Responsible for the High Initial Rates of Alcoholic Fermentation in Sake Yeast Strains of Saccharomyces cerevisiae. Appl Environ Microbiol. 2019 01 01; 85(1). Watanabe D, Kajihara T, Sugimoto Y, Takagi K, Mizuno M, Zhou Y, Chen J, Takeda K, Tatebe H, Shiozaki K, Nakazawa N, Izawa S, Akao T, Shimoi H, Maeda T, Takagi H. PMID: 30341081; PMCID: PMC6293112.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. The Rag GTPase-Ragulator complex attenuates TOR complex 1 signaling in fission yeast. Autophagy. 2018; 14(6):1105-1106. Fukuda T, Shiozaki K. PMID: 29799770; PMCID: PMC6103401.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria. Dev Comp Immunol. 2018 08; 85:142-149. Matsumoto M, Araki K, Nishimura S, Kuriyama H, Nakanishi T, Shiozaki K, Takeuchi Y, Yamamoto A. PMID: 29665356.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Unique nuclear localization of Nile tilapia (Oreochromis niloticus) Neu4 sialidase is regulated by nuclear transport receptor importin α/β. Biochimie. 2018 Jun; 149:92-104. Honda A, Chigwechokha PK, Kamada-Futagami Y, Komatsu M, Shiozaki K. PMID: 29635043.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. Biological and Pathological Roles of Ganglioside Sialidases. Prog Mol Biol Transl Sci. 2018; 156:121-150. Miyagi T, Takahashi K, Yamamoto K, Shiozaki K, Yamaguchi K. PMID: 29747812.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    26. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Elife. 2017 12 04; 6. Chia KH, Fukuda T, Sofyantoro F, Matsuda T, Amai T, Shiozaki K. PMID: 29199950; PMCID: PMC5752196.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. Evolutionary Conservation of the Components in the TOR Signaling Pathways. Biomolecules. 2017 11 01; 7(4). Tatebe H, Shiozaki K. PMID: 29104218; PMCID: PMC5745459.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    28. Adjuvant effect of recombinant interleukin-12 in the Nocardiosis formalin-killed vaccine of the amberjack Seriola dumerili. Fish Shellfish Immunol. 2017 Aug; 67:263-269. Matsumoto M, Araki K, Hayashi K, Takeuchi Y, Shiozaki K, Suetake H, Yamamoto A. PMID: 28602739.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife. 2017 03 07; 6. Tatebe H, Murayama S, Yonekura T, Hatano T, Richter D, Furuya T, Kataoka S, Furuita K, Kojima C, Shiozaki K. PMID: 28264193; PMCID: PMC5340527.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    30. Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Apr; 194:22-27. Takumi S, Shimono T, Ikema S, Hotta Y, Chigwechokha PK, Shiozaki K, Sugiyama Y, Hashimoto M, Furukawa T, Komatsu M. PMID: 28163251.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    31. Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias latipes) accompanied with the accumulation of α2-3 sialo-glycoproteins. Biochimie. 2017 Apr; 135:63-71. Ryuzono S, Takase R, Kamada Y, Ikenaga T, Chigwechokha PK, Komatsu M, Shiozaki K. PMID: 28111290.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    32. Naringenin suppresses Edwardsiella tarda infection in GAKS cells by NanA sialidase inhibition. Fish Shellfish Immunol. 2017 Feb; 61:86-92. Shinyoshi S, Kamada Y, Matsusaki K, Chigwechokha PK, Tepparin S, Araki K, Komatsu M, Shiozaki K. PMID: 27988309.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. Eur J Pharmacol. 2016 Jul 05; 782:21-9. Yoshinaga A, Kajiya N, Oishi K, Kamada Y, Ikeda A, Chigwechokha PK, Kibe T, Kishida M, Kishida S, Komatsu M, Shiozaki K. PMID: 27105818.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice. PLoS One. 2016; 11(3):e0150796. Kanouchi H, Kakimoto T, Nakano H, Suzuki M, Nakai Y, Shiozaki K, Akikoka K, Otomaru K, Nagano M, Matsumoto M. PMID: 26943920; PMCID: PMC4778952.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    35. Positive regulation of myoblast differentiation by medaka Neu3b sialidase through gangliosides desialylation. Biochimie. 2016 Apr; 123:65-72. Shiozaki K, Harasaki Y, Fukuda M, Yoshinaga A, Ryuzono S, Chigwechokha PK, Komatsu M, Miyagi T. PMID: 26805383.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. Eel green fluorescent protein is associated with resistance to oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2016 Mar-Apr; 181-182:35-9. Funahashi A, Komatsu M, Furukawa T, Yoshizono Y, Yoshizono H, Orikawa Y, Takumi S, Shiozaki K, Hayashi S, Kaminishi Y, Itakura T. PMID: 26746389.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human. Gene. 2016 Jan 10; 575(2 Pt 2):513-523. Ryuzono S, Takase R, Oishi K, Ikeda A, Chigwechokha PK, Funahashi A, Komatsu M, Miyagi T, Shiozaki K. PMID: 26432003.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    38. Recombinant sialidase NanA (rNanA) cleaves α2-3 linked sialic acid of host cell surface N-linked glycoprotein to promote Edwardsiella tarda infection. Fish Shellfish Immunol. 2015 Nov; 47(1):34-45. Chigwechokha PK, Tabata M, Shinyoshi S, Oishi K, Araki K, Komatsu M, Itakura T, Shiozaki K. PMID: 26291491.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3. Food Chem Toxicol. 2015 Sep; 83:229-36. Ikema S, Takumi S, Maeda Y, Kurimoto T, Bohda S, Chigwechokha PK, Sugiyama Y, Shiozaki K, Furukawa T, Komatsu M. PMID: 26134461.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    40. Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation. PLoS One. 2015; 10(3):e0120578. Yamamoto K, Takahashi K, Shiozaki K, Yamaguchi K, Moriya S, Hosono M, Shima H, Miyagi T. PMID: 25803810; PMCID: PMC4372364.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum. Cancer Sci. 2015 Apr; 106(4):383-9. Hata K, Tochigi T, Sato I, Kawamura S, Shiozaki K, Wada T, Takahashi K, Moriya S, Yamaguchi K, Hosono M, Miyagi T. PMID: 25652216; PMCID: PMC4409881.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Naringin attenuates the cytotoxicity of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells. Environ Toxicol Pharmacol. 2015 Mar; 39(2):974-81. Takumi S, Ikema S, Hanyu T, Shima Y, Kurimoto T, Shiozaki K, Sugiyama Y, Park HD, Ando S, Furukawa T, Komatsu M. PMID: 25818985.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Phosphatidic acid-mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration. FASEB J. 2015 May; 29(5):2099-111. Shiozaki K, Takahashi K, Hosono M, Yamaguchi K, Hata K, Shiozaki M, Bassi R, Prinetti A, Sonnino S, Nitta K, Miyagi T. PMID: 25678627.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle. 2015; 14(6):848-56. Hatano T, Morigasaki S, Tatebe H, Ikeda K, Shiozaki K. PMID: 25590601; PMCID: PMC4612450.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    45. Plasma membrane-associated sialidase confers cancer initiation, promotion and progression. Adv Exp Med Biol. 2015; 842:139-45. Miyagi T, Takahashi K, Shiozaki K, Yamaguchi K, Hosono M. PMID: 25408341.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints. J Biomol NMR. 2015 Jan; 61(1):55-64. Furuita K, Kataoka S, Sugiki T, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C. PMID: 25428765.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    47. Microcystin-LR induces anoikis resistance to the hepatocyte uptake transporter OATP1B3-expressing cell lines. Toxicology. 2014 Dec 04; 326:53-61. Takano H, Takumi S, Ikema S, Mizoue N, Hotta Y, Shiozaki K, Sugiyama Y, Furukawa T, Komatsu M. PMID: 25456266.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    48. Nile Tilapia Neu3 sialidases: molecular cloning, functional characterization and expression in Oreochromis niloticus. Gene. 2014 Nov 15; 552(1):155-64. Chigwechokha PK, Komatsu M, Itakura T, Shiozaki K. PMID: 25234733.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    49. Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase. Fish Physiol Biochem. 2014 Oct; 40(5):1461-72. Shiozaki K, Ryuzono S, Matsushita N, Ikeda A, Takeshita K, Chigwechokha PK, Komatsu M, Miyagi T. PMID: 24744226.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. (1)H, (15)N and (13)C resonance assignments of the conserved region in the middle domain of S. pombe Sin1 protein. Biomol NMR Assign. 2015 Apr; 9(1):89-92. Kataoka S, Furuita K, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C. PMID: 24610629.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    51. Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation. ACS Med Chem Lett. 2013 Aug 08; 4(8):752-6. Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K. PMID: 24900742; PMCID: PMC4027534.
      View in: PubMed   Mentions: 3  
    52. Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast. Commun Integr Biol. 2013 Sep 01; 6(5):e25020. Morigasaki S, Shiozaki K. PMID: 24255738; PMCID: PMC3829895.
      View in: PubMed   Mentions: 5  
    53. A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. Org Biomol Chem. 2013 Apr 28; 11(16):2567-70. Komeda C, Ikeda A, Kikuchi J, Ishida-Kitagawa N, Tatebe H, Shiozaki K, Akiyama M. PMID: 23307046.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    54. Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol Biol Cell. 2013 Apr; 24(7):1083-92. Morigasaki S, Ikner A, Tatebe H, Shiozaki K. PMID: 23389634; PMCID: PMC3608495.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes). Biochimie. 2013 Feb; 95(2):280-9. Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T. PMID: 23032629.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    56. Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012; 7(7):e41132. Yamaguchi K, Shiozaki K, Moriya S, Koseki K, Wada T, Tateno H, Sato I, Asano M, Iwakura Y, Miyagi T. PMID: 22815940; PMCID: PMC3398939.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    57. Sialidase significance for cancer progression. Glycoconj J. 2012 Dec; 29(8-9):567-77. Miyagi T, Takahashi K, Hata K, Shiozaki K, Yamaguchi K. PMID: 22644327.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    58. Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. J Biol Chem. 2012 Apr 27; 287(18):14816-26. Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T. PMID: 22393058; PMCID: PMC3340223.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    59. Purification and identification of two carnosine-cleaving enzymes, carnosine dipeptidase I and Xaa-methyl-His dipeptidase, from Japanese eel (Anguilla japonica). Biochimie. 2012 Jun; 94(6):1281-90. Oku T, Ando S, Tsai HC, Yamashita Y, Ueno H, Shiozaki K, Nishi R, Yamada S. PMID: 22525515.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    60. Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4. J Biol Chem. 2011 Jun 17; 286(24):21052-61. Shiozaki K, Yamaguchi K, Takahashi K, Moriya S, Miyagi T. PMID: 21521691; PMCID: PMC3122166.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    61. Purification and identification of a novel primitive secretory enzyme catalyzing the hydrolysis of imidazole-related dipeptides in the jawless vertebrate Lethenteron reissneri. Peptides. 2011 Apr; 32(4):648-55. Oku T, Ando S, Hayakawa T, Baba K, Nishi R, Shiozaki K, Yamada S. PMID: 21262300.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    62. Rab small GTPase emerges as a regulator of TOR complex 2. Small GTPases. 2010 Nov; 1(3):180-182. Tatebe H, Shiozaki K. PMID: 21625337; PMCID: PMC3103070.
      View in: PubMed   Mentions: 9     Fields:    
    63. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol. 2010 Nov 23; 20(22):1975-82. Tatebe H, Morigasaki S, Murayama S, Zeng CT, Shiozaki K. PMID: 21035342; PMCID: PMC3008323.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    64. Two-component signaling to the stress MAP kinase cascade in fission yeast. Methods Enzymol. 2010; 471:279-89. Morigasaki S, Shiozaki K. PMID: 20946853.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    65. Nutrition-minded cell cycle. Sci Signal. 2009 Nov 10; 2(96):pe74. Shiozaki K. PMID: 19903940.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    66. Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. J Biol Chem. 2009 Aug 07; 284(32):21157-64. Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T. PMID: 19506080; PMCID: PMC2755838.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    67. Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Cancer Sci. 2009 Apr; 100(4):588-94. Shiozaki K, Yamaguchi K, Sato I, Miyagi T. PMID: 19215228.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    68. Human sialidase as a cancer marker. Proteomics. 2008 Aug; 8(16):3303-11. Miyagi T, Wada T, Yamaguchi K, Shiozaki K, Sato I, Kakugawa Y, Yamanami H, Fujiya T. PMID: 18651674.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    69. Plasma membrane-associated sialidase as a crucial regulator of transmembrane signalling. J Biochem. 2008 Sep; 144(3):279-85. Miyagi T, Wada T, Yamaguchi K, Hata K, Shiozaki K. PMID: 18632803.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    70. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Mol Cell. 2008 Apr 11; 30(1):108-13. Morigasaki S, Shimada K, Ikner A, Yanagida M, Shiozaki K. PMID: 18406331; PMCID: PMC2374695.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    71. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Curr Biol. 2008 Mar 11; 18(5):322-30. Tatebe H, Nakano K, Maximo R, Shiozaki K. PMID: 18328707; PMCID: PMC2277499.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    72. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle. 2008 Feb 01; 7(3):358-64. Ikeda K, Morigasaki S, Tatebe H, Tamanoi F, Shiozaki K. PMID: 18235227; PMCID: PMC2274895.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    73. Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers. Cancer Sci. 2007 Mar; 98(3):299-307. Yamanami H, Shiozaki K, Wada T, Yamaguchi K, Uemura T, Kakugawa Y, Hujiya T, Miyagi T. PMID: 17270019.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    74. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Lett. 2006 May 01; 580(10):2409-13. Wang LY, Shiozaki K. PMID: 16603158.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    75. Inhibitory effects of hot water extract of the Stevia stem on the contractile response of the smooth muscle of the guinea pig ileum. Biosci Biotechnol Biochem. 2006 Feb; 70(2):489-94. Shiozaki K, Fujii A, Nakano T, Yamaguchi T, Sato M. PMID: 16495667.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    76. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Biochem J. 2005 Aug 15; 390(Pt 1):85-93. Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, Moriya S, Miyagi T. PMID: 15847605; PMCID: PMC1184564.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    77. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Curr Biol. 2005 Jun 07; 15(11):1006-15. Tatebe H, Shimada K, Uzawa S, Morigasaki S, Shiozaki K. PMID: 15936270.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    78. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase. Mol Cell Biol. 2005 May; 25(10):3945-55. Wang LY, Shimada K, Morishita M, Shiozaki K. PMID: 15870269; PMCID: PMC1087739.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    79. Yeast signaling pathways in the oxidative stress response. Mutat Res. 2005 Jan 06; 569(1-2):13-27. Ikner A, Shiozaki K. PMID: 15603750.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    80. Phosphorelay signaling in yeast in response to changes in osmolarity. Sci STKE. 2004 Dec 07; 2004(262):tr12. Santos JL, Shiozaki K. PMID: 15585692.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    81. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Mol Cell Biol. 2003 Aug; 23(15):5132-42. Tatebe H, Shiozaki K. PMID: 12861001; PMCID: PMC165716.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    82. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Mol Biol Cell. 2002 Aug; 13(8):2651-63. Nguyen AN, Ikner AD, Shiozaki M, Warren SM, Shiozaki K. PMID: 12181336; PMCID: PMC117932.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    83. SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans. Mol Microbiol. 2002 Aug; 45(4):1153-63. Kawasaki L, Sánchez O, Shiozaki K, Aguirre J. PMID: 12180932.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    84. Fungal histidine kinases. Sci STKE. 2001 Sep 04; 2001(98):re1. Santos JL, Shiozaki K. PMID: 11752677.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
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