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Kazuhiro Shiozaki

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InstitutionUniversity of California Davis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fukuda T, Shiozaki K. The Rag GTPase-Ragulator complex attenuates TOR complex 1 signaling in fission yeast. Autophagy. 2018 May 25; 1-2. PMID: 29799770.
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    2. Matsumoto M, Araki K, Nishimura S, Kuriyama H, Nakanishi T, Shiozaki K, Takeuchi Y, Yamamoto A. Adjuvant effect in aquaculture fish of cell-wall glycolipids isolated from acid-fast bacteria. Dev Comp Immunol. 2018 Aug; 85:142-149. PMID: 29665356.
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    3. Honda A, Chigwechokha PK, Kamada-Futagami Y, Komatsu M, Shiozaki K. Unique nuclear localization of Nile tilapia (Oreochromis niloticus) Neu4 sialidase is regulated by nuclear transport receptor importin a/ß. Biochimie. 2018 Jun; 149:92-104. PMID: 29635043.
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    4. Miyagi T, Takahashi K, Yamamoto K, Shiozaki K, Yamaguchi K. Biological and Pathological Roles of Ganglioside Sialidases. Prog Mol Biol Transl Sci. 2018; 156:121-150. PMID: 29747812.
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    5. Chia KH, Fukuda T, Sofyantoro F, Matsuda T, Amai T, Shiozaki K. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Elife. 2017 12 04; 6. PMID: 29199950.
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    6. Tatebe H, Shiozaki K. Evolutionary Conservation of the Components in the TOR Signaling Pathways. Biomolecules. 2017 Nov 01; 7(4). PMID: 29104218.
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    7. Matsumoto M, Araki K, Hayashi K, Takeuchi Y, Shiozaki K, Suetake H, Yamamoto A. Adjuvant effect of recombinant interleukin-12 in the Nocardiosis formalin-killed vaccine of the amberjack Seriola dumerili. Fish Shellfish Immunol. 2017 Aug; 67:263-269. PMID: 28602739.
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    8. Tatebe H, Murayama S, Yonekura T, Hatano T, Richter D, Furuya T, Kataoka S, Furuita K, Kojima C, Shiozaki K. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife. 2017 03 07; 6. PMID: 28264193.
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    9. Takumi S, Shimono T, Ikema S, Hotta Y, Chigwechokha PK, Shiozaki K, Sugiyama Y, Hashimoto M, Furukawa T, Komatsu M. Overexpression of carboxylesterase contributes to the attenuation of cyanotoxin microcystin-LR toxicity. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Apr; 194:22-27. PMID: 28163251.
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    10. Ryuzono S, Takase R, Kamada Y, Ikenaga T, Chigwechokha PK, Komatsu M, Shiozaki K. Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias latipes) accompanied with the accumulation of a2-3 sialo-glycoproteins. Biochimie. 2017 Apr; 135:63-71. PMID: 28111290.
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    11. Shinyoshi S, Kamada Y, Matsusaki K, Chigwechokha PK, Tepparin S, Araki K, Komatsu M, Shiozaki K. Naringenin suppresses Edwardsiella tarda infection in GAKS cells by NanA sialidase inhibition. Fish Shellfish Immunol. 2017 Feb; 61:86-92. PMID: 27988309.
      View in: PubMed
    12. Yoshinaga A, Kajiya N, Oishi K, Kamada Y, Ikeda A, Chigwechokha PK, Kibe T, Kishida M, Kishida S, Komatsu M, Shiozaki K. NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. Eur J Pharmacol. 2016 Jul 05; 782:21-9. PMID: 27105818.
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    13. Kanouchi H, Kakimoto T, Nakano H, Suzuki M, Nakai Y, Shiozaki K, Akikoka K, Otomaru K, Nagano M, Matsumoto M. The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice. PLoS One. 2016; 11(3):e0150796. PMID: 26943920; PMCID: PMC4778952.
    14. Shiozaki K, Harasaki Y, Fukuda M, Yoshinaga A, Ryuzono S, Chigwechokha PK, Komatsu M, Miyagi T. Positive regulation of myoblast differentiation by medaka Neu3b sialidase through gangliosides desialylation. Biochimie. 2016 Apr; 123:65-72. PMID: 26805383.
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    15. Funahashi A, Komatsu M, Furukawa T, Yoshizono Y, Yoshizono H, Orikawa Y, Takumi S, Shiozaki K, Hayashi S, Kaminishi Y, Itakura T. Eel green fluorescent protein is associated with resistance to oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol. 2016 Mar-Apr; 181-182:35-9. PMID: 26746389.
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    16. Ryuzono S, Takase R, Oishi K, Ikeda A, Chigwechokha PK, Funahashi A, Komatsu M, Miyagi T, Shiozaki K. Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human. Gene. 2016 Jan 10; 575(2 Pt 2):513-523. PMID: 26432003.
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    17. Chigwechokha PK, Tabata M, Shinyoshi S, Oishi K, Araki K, Komatsu M, Itakura T, Shiozaki K. Recombinant sialidase NanA (rNanA) cleaves a2-3 linked sialic acid of host cell surface N-linked glycoprotein to promote Edwardsiella tarda infection. Fish Shellfish Immunol. 2015 Nov; 47(1):34-45. PMID: 26291491.
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    18. Ikema S, Takumi S, Maeda Y, Kurimoto T, Bohda S, Chigwechokha PK, Sugiyama Y, Shiozaki K, Furukawa T, Komatsu M. Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3. Food Chem Toxicol. 2015 Sep; 83:229-36. PMID: 26134461.
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    19. Yamamoto K, Takahashi K, Shiozaki K, Yamaguchi K, Moriya S, Hosono M, Shima H, Miyagi T. Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation. PLoS One. 2015; 10(3):e0120578. PMID: 25803810; PMCID: PMC4372364.
    20. Hata K, Tochigi T, Sato I, Kawamura S, Shiozaki K, Wada T, Takahashi K, Moriya S, Yamaguchi K, Hosono M, Miyagi T. Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum. Cancer Sci. 2015 Apr; 106(4):383-9. PMID: 25652216; PMCID: PMC4409881.
    21. Takumi S, Ikema S, Hanyu T, Shima Y, Kurimoto T, Shiozaki K, Sugiyama Y, Park HD, Ando S, Furukawa T, Komatsu M. Naringin attenuates the cytotoxicity of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells. Environ Toxicol Pharmacol. 2015 Mar; 39(2):974-81. PMID: 25818985.
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    22. Shiozaki K, Takahashi K, Hosono M, Yamaguchi K, Hata K, Shiozaki M, Bassi R, Prinetti A, Sonnino S, Nitta K, Miyagi T. Phosphatidic acid-mediated activation and translocation to the cell surface of sialidase NEU3, promoting signaling for cell migration. FASEB J. 2015 May; 29(5):2099-111. PMID: 25678627.
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    23. Miyagi T, Takahashi K, Shiozaki K, Yamaguchi K, Hosono M. Plasma membrane-associated sialidase confers cancer initiation, promotion and progression. Adv Exp Med Biol. 2015; 842:139-45. PMID: 25408341.
      View in: PubMed
    24. Hatano T, Morigasaki S, Tatebe H, Ikeda K, Shiozaki K. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Cell Cycle. 2015; 14(6):848-56. PMID: 25590601; PMCID: PMC4612450.
    25. Furuita K, Kataoka S, Sugiki T, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C. Utilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraints. J Biomol NMR. 2015 Jan; 61(1):55-64. PMID: 25428765.
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    26. Takano H, Takumi S, Ikema S, Mizoue N, Hotta Y, Shiozaki K, Sugiyama Y, Furukawa T, Komatsu M. Microcystin-LR induces anoikis resistance to the hepatocyte uptake transporter OATP1B3-expressing cell lines. Toxicology. 2014 Dec 04; 326:53-61. PMID: 25456266.
      View in: PubMed
    27. Chigwechokha PK, Komatsu M, Itakura T, Shiozaki K. Nile Tilapia Neu3 sialidases: molecular cloning, functional characterization and expression in Oreochromis niloticus. Gene. 2014 Nov 15; 552(1):155-64. PMID: 25234733.
      View in: PubMed
    28. Shiozaki K, Ryuzono S, Matsushita N, Ikeda A, Takeshita K, Chigwechokha PK, Komatsu M, Miyagi T. Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase. Fish Physiol Biochem. 2014 Oct; 40(5):1461-72. PMID: 24744226.
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    29. Kataoka S, Furuita K, Hattori Y, Kobayashi N, Ikegami T, Shiozaki K, Fujiwara T, Kojima C. (1)H, (15)N and (13)C resonance assignments of the conserved region in the middle domain of S. pombe Sin1 protein. Biomol NMR Assign. 2015 Apr; 9(1):89-92. PMID: 24610629.
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    30. Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K. Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation. ACS Med Chem Lett. 2013 Aug 08; 4(8):752-6. PMID: 24900742; PMCID: PMC4027534.
    31. Morigasaki S, Shiozaki K. Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast. Commun Integr Biol. 2013 Sep 01; 6(5):e25020. PMID: 24255738; PMCID: PMC3829895.
    32. Komeda C, Ikeda A, Kikuchi J, Ishida-Kitagawa N, Tatebe H, Shiozaki K, Akiyama M. A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen. Org Biomol Chem. 2013 Apr 28; 11(16):2567-70. PMID: 23307046.
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    33. Morigasaki S, Ikner A, Tatebe H, Shiozaki K. Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast. Mol Biol Cell. 2013 Apr; 24(7):1083-92. PMID: 23389634; PMCID: PMC3608495.
    34. Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T. Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes). Biochimie. 2013 Feb; 95(2):280-9. PMID: 23032629.
      View in: PubMed
    35. Yamaguchi K, Shiozaki K, Moriya S, Koseki K, Wada T, Tateno H, Sato I, Asano M, Iwakura Y, Miyagi T. Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012; 7(7):e41132. PMID: 22815940; PMCID: PMC3398939.
    36. Miyagi T, Takahashi K, Hata K, Shiozaki K, Yamaguchi K. Sialidase significance for cancer progression. Glycoconj J. 2012 Dec; 29(8-9):567-77. PMID: 22644327.
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    37. Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T. Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. J Biol Chem. 2012 Apr 27; 287(18):14816-26. PMID: 22393058; PMCID: PMC3340223.
    38. Oku T, Ando S, Tsai HC, Yamashita Y, Ueno H, Shiozaki K, Nishi R, Yamada S. Purification and identification of two carnosine-cleaving enzymes, carnosine dipeptidase I and Xaa-methyl-His dipeptidase, from Japanese eel (Anguilla japonica). Biochimie. 2012 Jun; 94(6):1281-90. PMID: 22525515.
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    39. Shiozaki K, Yamaguchi K, Takahashi K, Moriya S, Miyagi T. Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4. J Biol Chem. 2011 Jun 17; 286(24):21052-61. PMID: 21521691; PMCID: PMC3122166.
    40. Oku T, Ando S, Hayakawa T, Baba K, Nishi R, Shiozaki K, Yamada S. Purification and identification of a novel primitive secretory enzyme catalyzing the hydrolysis of imidazole-related dipeptides in the jawless vertebrate Lethenteron reissneri. Peptides. 2011 Apr; 32(4):648-55. PMID: 21262300.
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    41. Tatebe H, Shiozaki K. Rab small GTPase emerges as a regulator of TOR complex 2. Small GTPases. 2010 Nov; 1(3):180-182. PMID: 21625337.
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    42. Tatebe H, Morigasaki S, Murayama S, Zeng CT, Shiozaki K. Rab-family GTPase regulates TOR complex 2 signaling in fission yeast. Curr Biol. 2010 Nov 23; 20(22):1975-82. PMID: 21035342; PMCID: PMC3008323.
    43. Morigasaki S, Shiozaki K. Two-component signaling to the stress MAP kinase cascade in fission yeast. Methods Enzymol. 2010; 471:279-89. PMID: 20946853.
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    44. Shiozaki K. Nutrition-minded cell cycle. Sci Signal. 2009 Nov 10; 2(96):pe74. PMID: 19903940.
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    45. Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T. Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. J Biol Chem. 2009 Aug 07; 284(32):21157-64. PMID: 19506080; PMCID: PMC2755838.
    46. Shiozaki K, Yamaguchi K, Sato I, Miyagi T. Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Cancer Sci. 2009 Apr; 100(4):588-94. PMID: 19215228.
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    47. Miyagi T, Wada T, Yamaguchi K, Shiozaki K, Sato I, Kakugawa Y, Yamanami H, Fujiya T. Human sialidase as a cancer marker. Proteomics. 2008 Aug; 8(16):3303-11. PMID: 18651674.
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    48. Miyagi T, Wada T, Yamaguchi K, Hata K, Shiozaki K. Plasma membrane-associated sialidase as a crucial regulator of transmembrane signalling. J Biochem. 2008 Sep; 144(3):279-85. PMID: 18632803.
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    49. Morigasaki S, Shimada K, Ikner A, Yanagida M, Shiozaki K. Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade. Mol Cell. 2008 Apr 11; 30(1):108-13. PMID: 18406331; PMCID: PMC2374695.
    50. Tatebe H, Nakano K, Maximo R, Shiozaki K. Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Curr Biol. 2008 Mar 11; 18(5):322-30. PMID: 18328707; PMCID: PMC2277499.
    51. Ikeda K, Morigasaki S, Tatebe H, Tamanoi F, Shiozaki K. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle. 2008 Feb 01; 7(3):358-64. PMID: 18235227; PMCID: PMC2274895.
    52. Yamanami H, Shiozaki K, Wada T, Yamaguchi K, Uemura T, Kakugawa Y, Hujiya T, Miyagi T. Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers. Cancer Sci. 2007 Mar; 98(3):299-307. PMID: 17270019.
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    53. Wang LY, Shiozaki K. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Lett. 2006 May 01; 580(10):2409-13. PMID: 16603158.
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    54. Shiozaki K, Fujii A, Nakano T, Yamaguchi T, Sato M. Inhibitory effects of hot water extract of the Stevia stem on the contractile response of the smooth muscle of the guinea pig ileum. Biosci Biotechnol Biochem. 2006 Feb; 70(2):489-94. PMID: 16495667.
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    55. Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, Moriya S, Miyagi T. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Biochem J. 2005 Aug 15; 390(Pt 1):85-93. PMID: 15847605; PMCID: PMC1184564.
    56. Tatebe H, Shimada K, Uzawa S, Morigasaki S, Shiozaki K. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Curr Biol. 2005 Jun 07; 15(11):1006-15. PMID: 15936270.
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    57. Wang LY, Shimada K, Morishita M, Shiozaki K. Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase. Mol Cell Biol. 2005 May; 25(10):3945-55. PMID: 15870269; PMCID: PMC1087739.
    58. Ikner A, Shiozaki K. Yeast signaling pathways in the oxidative stress response. Mutat Res. 2005 Jan 06; 569(1-2):13-27. PMID: 15603750.
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    59. Santos JL, Shiozaki K. Phosphorelay signaling in yeast in response to changes in osmolarity. Sci STKE. 2004 Dec 07; 2004(262):tr12. PMID: 15585692.
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    60. Tatebe H, Shiozaki K. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Mol Cell Biol. 2003 Aug; 23(15):5132-42. PMID: 12861001; PMCID: PMC165716.
    61. Kawasaki L, Sánchez O, Shiozaki K, Aguirre J. SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans. Mol Microbiol. 2002 Aug; 45(4):1153-63. PMID: 12180932.
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    62. Nguyen AN, Ikner AD, Shiozaki M, Warren SM, Shiozaki K. Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast. Mol Biol Cell. 2002 Aug; 13(8):2651-63. PMID: 12181336; PMCID: PMC117932.
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