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Xi Chen

Title(s)Professor, Chemistry
SchoolUniversity of California, Davis
Phone530-754-6037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leviatan Ben-Arye S, Schneider C, Yu H, Bashir S, Chen X, von Gunten S, Padler-Karavani V. Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies. Bioconjug Chem. 2019 May 15; 30(5):1565-1574. PMID: 30994337.
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    2. Reuven EM, Leviatan Ben-Arye S, Yu H, Duchi R, Perota A, Conchon S, Bachar Abramovitch S, Soulillou JP, Galli C, Chen X, Padler-Karavani V. Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy. ACS Nano. 2019 Mar 26; 13(3):2936-2947. PMID: 30840433.
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    3. Rousse J, Salama A, Leviatan Ben-Arye S, Hruba P, Slatinska J, Evanno G, Duvaux O, Blanchard D, Yu H, Chen X, Bach JM, Padler-Karavani V, Viklicky O, Soulillou JP. Quantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients. Eur J Clin Invest. 2019 Apr; 49(4):e13069. PMID: 30620396.
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    4. Yuen PK, Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS. Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry. ACS Chem Biol. 2019 01 18; 14(1):27-36. PMID: 30500207.
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    5. Bashir S, Leviatan Ben Arye S, Reuven EM, Yu H, Costa C, Galiñanes M, Bottio T, Chen X, Padler-Karavani V. Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies. Bioconjug Chem. 2019 01 16; 30(1):161-168. PMID: 30500162.
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    6. Tasnima N, Yu H, Yan X, Li W, Xiao A, Chen X. Facile chemoenzymatic synthesis of Lewis a (Lea) antigen in gram-scale and sialyl Lewis a (sLea) antigens containing diverse sialic acid forms. Carbohydr Res. 2019 Jan 15; 472:115-121. PMID: 30562693.
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    7. Li W, McArthur JB, Chen X. Strategies for chemoenzymatic synthesis of carbohydrates. Carbohydr Res. 2019 Jan 15; 472:86-97. PMID: 30529493.
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    8. Slack TJ, Li W, Shi D, McArthur JB, Zhao G, Li Y, Xiao A, Khedri Z, Yu H, Liu Y, Chen X. Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem. 2018 11 15; 26(21):5751-5757. PMID: 30389408.
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    9. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. PMID: 29912959.
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    10. Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, Varki A. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PLoS One. 2018; 13(6):e0197464. PMID: 29912879.
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    11. Yu H, Santra A, Li Y, McArthur JB, Ghosh T, Yang X, Wang PG, Chen X. Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens. Org Biomol Chem. 2018 06 06; 16(22):4076-4080. PMID: 29789847.
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    12. Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 06; 86(6). PMID: 29581195.
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    13. McArthur JB, Yu H, Tasnima N, Lee CM, Fisher AJ, Chen X. a2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase. ACS Chem Biol. 2018 05 18; 13(5):1228-1234. PMID: 29543427.
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    14. Santra A, Xiao A, Yu H, Li W, Li Y, Ngo L, McArthur JB, Chen X. A Diazido Mannose Analogue as a Chemoenzymatic Synthon for Synthesizing Di-N-acetyllegionaminic Acid-Containing Glycosides. Angew Chem Int Ed Engl. 2018 03 05; 57(11):2929-2933. PMID: 29349857.
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    15. Ming SA, Cottman-Thomas E, Black NC, Chen Y, Veeramachineni V, Peterson DC, Chen X, Tedaldi LM, Wagner GK, Cai C, Linhardt RJ, Vann WF. Interaction of Neisseria meningitidis Group X N-acetylglucosamine-1-phosphotransferase with its donor substrate. Glycobiology. 2018 02 01; 28(2):100-107. PMID: 29228283.
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    16. Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun. 2017 12 19; 8(1):2196. PMID: 29259165.
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    17. Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. BMC Evol Biol. 2017 11 23; 17(1):228. PMID: 29169316.
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    18. Yu H, Yan X, Autran CA, Li Y, Etzold S, Latasiewicz J, Robertson BM, Li J, Bode L, Chen X. Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects. J Org Chem. 2017 12 15; 82(24):13152-13160. PMID: 29124935.
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    19. Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol. 2017 Dec; 2(12):1592-1599. PMID: 28993610.
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    20. Yu H, Li Y, Wu Z, Li L, Zeng J, Zhao C, Wu Y, Tasnima N, Wang J, Liu H, Gadi MR, Guan W, Wang PG, Chen X. H. pylori a1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides. Chem Commun (Camb). 2017 Oct 05; 53(80):11012-11015. PMID: 28936496.
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    21. Li W, Xiao A, Li Y, Yu H, Chen X. Chemoenzymatic synthesis of Neu5Ac9NAc-containing a2-3- and a2-6-linked sialosides and their use for sialidase substrate specificity studies. Carbohydr Res. 2017 Nov 08; 451:51-58. PMID: 28961426.
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    22. Monestier M, Latousakis D, Bell A, Tribolo S, Tailford LE, Colquhoun IJ, Le Gall G, Yu H, Chen X, Rejzek M, Dedola S, Field RA, Juge N. Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives. Carbohydr Res. 2017 Nov 08; 451:110-117. PMID: 28851488.
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    23. Cámara MLM, Cánepa GE, Lantos AB, Balouz V, Yu H, Chen X, Campetella O, Mucci J, Buscaglia CA. The Trypomastigote Small Surface Antigen (TSSA) regulates Trypanosoma cruzi infectivity and differentiation. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005856. PMID: 28800609.
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    24. Santra A, Li Y, Yu H, Slack TJ, Wang PG, Chen X. Highly efficient chemoenzymatic synthesis and facile purification of a-Gal pentasaccharyl ceramide Gala3nLc4ßCer. Chem Commun (Camb). 2017 Jul 20; 53(59):8280-8283. PMID: 28695219.
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    25. Leviatan Ben-Arye S, Yu H, Chen X, Padler-Karavani V. Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay. J Vis Exp. 2017 07 13; (125). PMID: 28745644.
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    26. Fu X, Shang W, Wang S, Liu Y, Qu J, Chen X, Wang PG, Fang J. A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. Chem Commun (Camb). 2017 Mar 23; 53(25):3555-3558. PMID: 28286894.
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    27. McArthur JB, Yu H, Zeng J, Chen X. Converting Pasteurella multocidaa2-3-sialyltransferase 1 (PmST1) to a regioselective a2-6-sialyltransferase by saturation mutagenesis and regioselective screening. Org Biomol Chem. 2017 Feb 21; 15(7):1700-1709. PMID: 28134951.
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    28. Tasnima N, Yu H, Li Y, Santra A, Chen X. Chemoenzymatic synthesis of para-nitrophenol (pNP)-tagged a2-8-sialosides and high-throughput substrate specificity studies of a2-8-sialidases. Org Biomol Chem. 2016 Dec 20; 15(1):160-167. PMID: 27924345.
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    29. Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X. A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids. ACS Chem Biol. 2017 01 20; 12(1):214-224. PMID: 27936566.
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    30. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E. J Biol Chem. 2017 01 20; 292(3):1029-1037. PMID: 27920204.
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    31. Tsering D, Chen C, Ye J, Han Z, Jing BQ, Liu XW, Chen X, Wang F, Ling P, Cao H. Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr Res. 2017 Jan 13; 438:39-43. PMID: 27960098.
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    32. Wu Z, Liu Y, Ma C, Li L, Bai J, Byrd-Leotis L, Lasanajak Y, Guo Y, Wen L, Zhu H, Song J, Li Y, Steinhauer DA, Smith DF, Zhao B, Chen X, Guan W, Wang PG. Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes. Org Biomol Chem. 2016 Nov 29; 14(47):11106-11116. PMID: 27752690.
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    33. Yu H, Li Y, Zeng J, Thon V, Nguyen DM, Ly T, Kuang HY, Ngo A, Chen X. Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans. J Org Chem. 2016 11 18; 81(22):10809-10824. PMID: 27736072.
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    34. Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415. PMID: 27689936.
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    35. Reuven EM, Leviatan Ben-Arye S, Marshanski T, Breimer ME, Yu H, Fellah-Hebia I, Roussel JC, Costa C, Galiñanes M, Mañez R, Le Tourneau T, Soulillou JP, Cozzi E, Chen X, Padler-Karavani V. Characterization of immunogenic Neu5Gc in bioprosthetic heart valves. Xenotransplantation. 2016 09; 23(5):381-92. PMID: 27610947.
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    36. Yu H, Zeng J, Li Y, Thon V, Shi B, Chen X. Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid. Org Biomol Chem. 2016 Sep 28; 14(36):8586-97. PMID: 27548611.
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    37. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 Apr 26; 14(17):4027-31. PMID: 27080952.
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    38. Lantos AB, Carlevaro G, Araoz B, Ruiz Diaz P, Camara Mde L, Buscaglia CA, Bossi M, Yu H, Chen X, Bertozzi CR, Mucci J, Campetella O. Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. PLoS Pathog. 2016 Apr; 12(4):e1005559. PMID: 27058585.
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    39. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. PMID: 27037304.
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    40. Yu H, Chen X. One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates. Org Biomol Chem. 2016 Mar 14; 14(10):2809-18. PMID: 26881499.
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    41. Li Y, Xue M, Sheng X, Yu H, Zeng J, Thon V, Chen Y, Muthana MM, Wang PG, Chen X. Donor substrate promiscuity of bacterial ß1-3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of ß1-4-galactosyltransferases. Bioorg Med Chem. 2016 Apr 15; 24(8):1696-705. PMID: 26968649.
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    42. Zhao C, Wu Y, Yu H, Shah IM, Li Y, Zeng J, Liu B, Mills DA, Chen X. The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates a1-2-fucosyltransferase. Chem Commun (Camb). 2016 Mar 11; 52(20):3899-902. PMID: 26864394.
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    43. McArthur JB, Chen X. Glycosyltransferase engineering for carbohydrate synthesis. Biochem Soc Trans. 2016 Feb; 44(1):129-42. PMID: 26862198.
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    44. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem. 2016 Apr 01; 291(14):7230-40. PMID: 26833566.
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    45. Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLoS Pathog. 2016 Jan; 12(1):e1005411. PMID: 26816272.
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    46. Santra A, Yu H, Tasnima N, Muthana MM, Li Y, Zeng J, Kenyond NJ, Louie AY, Chen X. Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. Chem Sci. 2016 Apr 01; 7(4):2827-2831. PMID: 28138383.
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    47. Chen X. Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis. Adv Carbohydr Chem Biochem. 2015; 72:113-90. PMID: 26613816.
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    48. Zhang L, Muthana MM, Yu H, McArthur JB, Qu J, Chen X. Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives. Carbohydr Res. 2016 Jan; 419:18-28. PMID: 26598987.
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    49. Fei Y, Sun YS, Li Y, Yu H, Lau K, Landry JP, Luo Z, Baumgarth N, Chen X, Zhu X. Characterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform. Biomolecules. 2015 Jul 16; 5(3):1480-98. PMID: 26193329.
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    50. Li L, Liu Y, Li T, Wang W, Yu Z, Ma C, Qu J, Zhao W, Chen X, Wang PG. Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. Chem Commun (Camb). 2015 Jun 28; 51(51):10310-3. PMID: 26023910.
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    51. Zhang Y, Meng C, Jin L, Chen X, Wang F, Cao H. Chemoenzymatic synthesis of a-dystroglycan core M1 O-mannose glycans. Chem Commun (Camb). 2015 Jul 25; 51(58):11654-7. PMID: 26100261.
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    52. Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ. Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Rep. 2015 Jun 30; 11(12):1966-78. PMID: 26095364.
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    53. Wu B, Wei N, Thon V, Wei M, Yu Z, Xu Y, Chen X, Liu J, Wang PG, Li T. Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. Org Biomol Chem. 2015 May 14; 13(18):5098-101. PMID: 25858766.
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    54. Chen C, Zhang Y, Xue M, Liu XW, Li Y, Chen X, Wang PG, Wang F, Cao H. Sequential one-pot multienzyme (OPME) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives. Chem Commun (Camb). 2015 May 04; 51(36):7689-92. PMID: 25848722.
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    55. Ngo A, Fong KT, Cox DL, Chen X, Fisher AJ. Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Crystallogr D Biol Crystallogr. 2015 May; 71(Pt 5):1068-76. PMID: 25945572.
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    56. Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. J Virol. 2015 Jul; 89(13):6860-73. PMID: 25903329.
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    57. Muthana MM, Qu J, Xue M, Klyuchnik T, Siu A, Li Y, Zhang L, Yu H, Li L, Wang PG, Chen X. Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides. Chem Commun (Camb). 2015 Mar 18; 51(22):4595-8. PMID: 25686901.
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    58. Peralta MD, Karsai A, Ngo A, Sierra C, Fong KT, Hayre NR, Mirzaee N, Ravikumar KM, Kluber AJ, Chen X, Liu GY, Toney MD, Singh RR, Cox DL. Engineering amyloid fibrils from ß-solenoid proteins for biomaterials applications. ACS Nano. 2015 Jan 27; 9(1):449-63. PMID: 25562726.
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    59. Ding L, Zhao C, Qu J, Li Y, Sugiarto G, Yu H, Wang J, Chen X. A Photobacterium sp. a2-6-sialyltransferase (Psp2,6ST) mutant with an increased expression level and improved activities in sialylating Tn antigens. Carbohydr Res. 2015 May 18; 408:127-33. PMID: 25593075.
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    60. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 2014 Dec 04; 159(6):1290-9. PMID: 25480294.
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    61. Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A. Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. PLoS Pathog. 2014 Dec; 10(12):e1004540. PMID: 25474103.
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    62. Huynh N, Li Y, Yu H, Huang S, Lau K, Chen X, Fisher AJ. Crystal structures of sialyltransferase from Photobacterium damselae. FEBS Lett. 2014 Dec 20; 588(24):4720-9. PMID: 25451227.
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    63. Yao W, Yan J, Chen X, Wang F, Cao H. Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. Carbohydr Res. 2015 Jan 12; 401:5-10. PMID: 25464075.
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    64. Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X, van de Vlekkert D, D'Azzo A, Zheng P, Liu Y. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. Elife. 2014 Sep 03; 3:e04066. PMID: 25187624.
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    65. Yu H, Lau K, Thon V, Autran CA, Jantscher-Krenn E, Xue M, Li Y, Sugiarto G, Qu J, Mu S, Ding L, Bode L, Chen X. Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis. Angew Chem Int Ed Engl. 2014 Jun 23; 53(26):6687-91. PMID: 24848971.
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    66. Meng X, Yao W, Cheng J, Zhang X, Jin L, Yu H, Chen X, Wang F, Cao H. Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes. J Am Chem Soc. 2014 Apr 09; 136(14):5205-8. PMID: 24649890.
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    67. Khedri Z, Li Y, Muthana S, Muthana MM, Hsiao CW, Yu H, Chen X. Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies. Carbohydr Res. 2014 May 07; 389:100-11. PMID: 24680514.
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    68. Hwang J, Yu H, Malekan H, Sugiarto G, Li Y, Qu J, Nguyen V, Wu D, Chen X. Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification. Chem Commun (Camb). 2014 Mar 25; 50(24):3159-62. PMID: 24473465.
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    69. Halder S, Cotmore S, Heimburg-Molinaro J, Smith DF, Cummings RD, Chen X, Trollope AJ, North SJ, Haslam SM, Dell A, Tattersall P, McKenna R, Agbandje-McKenna M. Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition. PLoS One. 2014; 9(1):e86909. PMID: 24475195.
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    70. Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014 Mar; 28(3):1280-93. PMID: 24308974.
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    71. Huynh N, Aye A, Li Y, Yu H, Cao H, Tiwari VK, Shin DW, Chen X, Fisher AJ. Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry. 2013 Nov 26; 52(47):8570-9. PMID: 24152047.
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    72. Fei Y, Landry JP, Li Y, Yu H, Lau K, Huang S, Chokhawala HA, Chen X, Zhu XD. An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support. Rev Sci Instrum. 2013 Nov; 84(11):114102. PMID: 24289409.
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    73. Li L, Liu Y, Wan Y, Li Y, Chen X, Zhao W, Wang PG. Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives. Org Lett. 2013 Nov 01; 15(21):5528-30. PMID: 24117142.
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    74. Deng L, Chen X, Varki A. Exploration of sialic acid diversity and biology using sialoglycan microarrays. Biopolymers. 2013 Oct; 99(10):650-65. PMID: 23765393.
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    75. Chen Y, Li Y, Yu H, Sugiarto G, Thon V, Hwang J, Ding L, Hie L, Chen X. Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems. Angew Chem Int Ed Engl. 2013 Nov 04; 52(45):11852-6. PMID: 24038939.
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    76. Scobie L, Padler-Karavani V, Le Bas-Bernardet S, Crossan C, Blaha J, Matouskova M, Hector RD, Cozzi E, Vanhove B, Charreau B, Blancho G, Bourdais L, Tallacchini M, Ribes JM, Yu H, Chen X, Kracikova J, Broz L, Hejnar J, Vesely P, Takeuchi Y, Varki A, Soulillou JP. Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol. 2013 Sep 15; 191(6):2907-15. PMID: 23945141.
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    77. Ma X, Liu P, Yan H, Sun H, Liu X, Zhou F, Li L, Chen Y, Muthana MM, Chen X, Wang PG, Zhang L. Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). PLoS One. 2013; 8(5):e63452. PMID: 23700425.
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    78. Li Y, Yu H, Thon V, Chen Y, Muthana MM, Qu J, Hie L, Chen X. Donor substrate promiscuity of the N-acetylglucosaminyltransferase activities of Pasteurella multocida heparosan synthase 2 (PmHS2) and Escherichia coli K5 KfiA. Appl Microbiol Biotechnol. 2014 Feb; 98(3):1127-34. PMID: 23661084.
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    79. Kikkeri R, Padler-Karavani V, Diaz S, Verhagen A, Yu H, Cao H, Langereis MA, De Groot RJ, Chen X, Varki A. Quantum dot nanometal surface energy transfer based biosensing of sialic acid compositions and linkages in biological samples. Anal Chem. 2013 Apr 16; 85(8):3864-70. PMID: 23489180.
      View in: PubMed
    80. Padler-Karavani V, Tremoulet AH, Yu H, Chen X, Burns JC, Varki A. A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. PLoS One. 2013; 8(3):e58443. PMID: 23520510.
      View in: PubMed
    81. Malekan H, Fung G, Thon V, Khedri Z, Yu H, Qu J, Li Y, Ding L, Lam KS, Chen X. One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid. Bioorg Med Chem. 2013 Aug 15; 21(16):4778-85. PMID: 23535562.
      View in: PubMed
    82. Yan J, Chen X, Wang F, Cao H. Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives. Org Biomol Chem. 2013 Feb 07; 11(5):842-8. PMID: 23241945.
      View in: PubMed
    83. Cánepa GE, Mesías AC, Yu H, Chen X, Buscaglia CA. Structural features affecting trafficking, processing, and secretion of Trypanosoma cruzi mucins. J Biol Chem. 2012 Jul 27; 287(31):26365-76. PMID: 22707724.
      View in: PubMed
    84. Khedri Z, Li Y, Cao H, Qu J, Yu H, Muthana MM, Chen X. Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2. Org Biomol Chem. 2012 Aug 14; 10(30):6112-20. PMID: 22641268.
      View in: PubMed
    85. Sugiarto G, Lau K, Qu J, Li Y, Lim S, Mu S, Ames JB, Fisher AJ, Chen X. A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX. ACS Chem Biol. 2012 Jul 20; 7(7):1232-40. PMID: 22583967.
      View in: PubMed
    86. Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 2012 Jun 29; 287(27):22593-608. PMID: 22549775.
      View in: PubMed
    87. Li Y, Chen X. Sialic acid metabolism and sialyltransferases: natural functions and applications. Appl Microbiol Biotechnol. 2012 May; 94(4):887-905. PMID: 22526796.
      View in: PubMed
    88. Lu Q, Padler-Karavani V, Yu H, Chen X, Wu SL, Varki A, Hancock WS. LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion. Anal Chem. 2012 Mar 20; 84(6):2761-8. PMID: 22390546.
      View in: PubMed
    89. Khedri Z, Muthana MM, Li Y, Muthana SM, Yu H, Cao H, Chen X. Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid. Chem Commun (Camb). 2012 Apr 04; 48(27):3357-9. PMID: 22361713.
      View in: PubMed
    90. Muthana MM, Qu J, Li Y, Zhang L, Yu H, Ding L, Malekan H, Chen X. Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP). Chem Commun (Camb). 2012 Mar 11; 48(21):2728-30. PMID: 22306833.
      View in: PubMed
    91. Cao H, Chen X. General consideration on sialic acid chemistry. Methods Mol Biol. 2012; 808:31-56. PMID: 22057516.
      View in: PubMed
    92. Linman MJ, Yu H, Chen X, Cheng Q. Surface plasmon resonance imaging analysis of protein binding to a sialoside-based carbohydrate microarray. Methods Mol Biol. 2012; 808:183-94. PMID: 22057526.
      View in: PubMed
    93. Thon V, Li Y, Yu H, Lau K, Chen X. PmST3 from Pasteurella multocida encoded by Pm1174 gene is a monofunctional a2-3-sialyltransferase. Appl Microbiol Biotechnol. 2012 May; 94(4):977-85. PMID: 22075637.
      View in: PubMed
    94. Fei Y, Sun YS, Li Y, Lau K, Yu H, Chokhawala HA, Huang S, Landry JP, Chen X, Zhu X. Fluorescent labeling agents change binding profiles of glycan-binding proteins. Mol Biosyst. 2011 Dec; 7(12):3343-52. PMID: 22009201.
      View in: PubMed
    95. Li Y, Yu H, Cao H, Muthana S, Chen X. Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity. Appl Microbiol Biotechnol. 2012 Mar; 93(6):2411-23. PMID: 21968653.
      View in: PubMed
    96. Bradley KC, Galloway SE, Lasanajak Y, Song X, Heimburg-Molinaro J, Yu H, Chen X, Talekar GR, Smith DF, Cummings RD, Steinhauer DA. Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics. J Virol. 2011 Dec; 85(23):12387-98. PMID: 21917953.
      View in: PubMed
    97. Urban I, Santurio LB, Chidichimo A, Yu H, Chen X, Mucci J, Agüero F, Buscaglia CA. Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins. Biochem J. 2011 Sep 01; 438(2):303-13. PMID: 21651499.
      View in: PubMed
    98. Chen Y, Thon V, Li Y, Yu H, Ding L, Lau K, Qu J, Hie L, Chen X. One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. Chem Commun (Camb). 2011 Oct 14; 47(38):10815-7. PMID: 21863157.
      View in: PubMed
    99. Sugiarto G, Lau K, Li Y, Khedri Z, Yu H, Le DT, Chen X. Decreasing the sialidase activity of multifunctional Pasteurella multocida a2-3-sialyltransferase 1 (PmST1) by site-directed mutagenesis. Mol Biosyst. 2011 Nov; 7(11):3021-7. PMID: 21858283.
      View in: PubMed
    100. Li Y, Yu H, Chen Y, Lau K, Cai L, Cao H, Tiwari VK, Qu J, Thon V, Wang PG, Chen X. Substrate promiscuity of N-acetylhexosamine 1-kinases. Molecules. 2011 Jul 28; 16(8):6396-407. PMID: 21799473.
      View in: PubMed
    101. Song X, Yu H, Chen X, Lasanajak Y, Tappert MM, Air GM, Tiwari VK, Cao H, Chokhawala HA, Zheng H, Cummings RD, Smith DF. A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses. J Biol Chem. 2011 Sep 09; 286(36):31610-22. PMID: 21757734.
      View in: PubMed
    102. Pourceau G, Chevolot Y, Goudot A, Giroux F, Meyer A, Moulés V, Lina B, Cecioni S, Vidal S, Yu H, Chen X, Ferraris O, Praly JP, Souteyrand E, Vasseur JJ, Morvan F. Measurement of enzymatic activity and specificity of human and avian influenza neuraminidases from whole virus by glycoarray and MALDI-TOF mass spectrometry. Chembiochem. 2011 Sep 05; 12(13):2071-80. PMID: 21739555.
      View in: PubMed
    103. Ding L, Yu H, Lau K, Li Y, Muthana S, Wang J, Chen X. Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. Chem Commun (Camb). 2011 Aug 14; 47(30):8691-3. PMID: 21725542.
      View in: PubMed
    104. Yu H, Cao H, Tiwari VK, Li Y, Chen X. Chemoenzymatic synthesis of C8-modified sialic acids and related a2-3- and a2-6-linked sialosides. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5037-40. PMID: 21592790.
      View in: PubMed
    105. Thon V, Lau K, Yu H, Tran BK, Chen X. PmST2: a novel Pasteurella multocida glycolipid a2-3-sialyltransferase. Glycobiology. 2011 Sep; 21(9):1206-16. PMID: 21515586.
      View in: PubMed
    106. Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 2011 May 01; 71(9):3352-63. PMID: 21505105.
      View in: PubMed
    107. Li Y, Cao H, Dao N, Luo Z, Yu H, Chen Y, Xing Z, Baumgarth N, Cardona C, Chen X. High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses. Virology. 2011 Jun 20; 415(1):12-9. PMID: 21501853.
      View in: PubMed
    108. Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol. 2011 May; 29(5):428-35. PMID: 21478876.
      View in: PubMed
    109. Lau K, Yu H, Thon V, Khedri Z, Leon ME, Tran BK, Chen X. Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives. Org Biomol Chem. 2011 Apr 21; 9(8):2784-9. PMID: 21359399.
      View in: PubMed
    110. Sela DA, Li Y, Lerno L, Wu S, Marcobal AM, German JB, Chen X, Lebrilla CB, Mills DA. An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides. J Biol Chem. 2011 Apr 08; 286(14):11909-18. PMID: 21288901.
      View in: PubMed
    111. Chen X. Fermenting next generation glycosylated therapeutics. ACS Chem Biol. 2011 Jan 21; 6(1):14-7. PMID: 21250649.
      View in: PubMed
    112. Li Y, Cao H, Yu H, Chen Y, Lau K, Qu J, Thon V, Sugiarto G, Chen X. Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies. Mol Biosyst. 2011 Apr; 7(4):1060-72. PMID: 21206954.
      View in: PubMed
    113. Sugiarto G, Lau K, Yu H, Vuong S, Thon V, Li Y, Huang S, Chen X. Cloning and characterization of a viral a2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx. Glycobiology. 2011 Mar; 21(3):387-96. PMID: 20978012.
      View in: PubMed
    114. Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X. Highly efficient chemoenzymatic synthesis of ß1-3-linked galactosides. Chem Commun (Camb). 2010 Oct 28; 46(40):7507-9. PMID: 20830443.
      View in: PubMed
    115. Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med. 2010 Aug 02; 207(8):1637-46. PMID: 20624889.
      View in: PubMed
    116. Lau K, Thon V, Yu H, Ding L, Chen Y, Muthana MM, Wong D, Huang R, Chen X. Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases. Chem Commun (Camb). 2010 Sep 07; 46(33):6066-8. PMID: 20625591.
      View in: PubMed
    117. Zhang L, Lau K, Cheng J, Yu H, Li Y, Sugiarto G, Huang S, Ding L, Thon V, Wang PG, Chen X. Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family. Glycobiology. 2010 Sep; 20(9):1077-88. PMID: 20466652.
      View in: PubMed
    118. Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, Bertozzi CR, Campetella O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 2010 Jul; 20(7):833-42. PMID: 20354005.
      View in: PubMed
    119. Chen X, Varki A. Advances in the biology and chemistry of sialic acids. ACS Chem Biol. 2010 Feb 19; 5(2):163-76. PMID: 20020717.
      View in: PubMed
    120. Yu H, Cheng J, Ding L, Khedri Z, Chen Y, Chin S, Lau K, Tiwari VK, Chen X. Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J Am Chem Soc. 2009 Dec 30; 131(51):18467-77. PMID: 19947630.
      View in: PubMed
    121. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. PMID: 19828701.
      View in: PubMed
    122. Cheng J, Huang S, Yu H, Li Y, Lau K, Chen X. Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides. Glycobiology. 2010 Feb; 20(2):260-8. PMID: 19880425.
      View in: PubMed
    123. Cao H, Li Y, Lau K, Muthana S, Yu H, Cheng J, Chokhawala HA, Sugiarto G, Zhang L, Chen X. Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org Biomol Chem. 2009 Dec 21; 7(24):5137-45. PMID: 20024109.
      View in: PubMed
    124. Muthana S, Cao H, Chen X. Recent progress in chemical and chemoenzymatic synthesis of carbohydrates. Curr Opin Chem Biol. 2009 Dec; 13(5-6):573-81. PMID: 19833544.
      View in: PubMed
    125. Cao H, Muthana S, Li Y, Cheng J, Chen X. Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. Bioorg Med Chem Lett. 2009 Oct 15; 19(20):5869-71. PMID: 19740656.
      View in: PubMed
    126. Linman MJ, Yu H, Chen X, Cheng Q. Fabrication and characterization of a sialoside-based carbohydrate microarray biointerface for protein binding analysis with surface plasmon resonance imaging. ACS Appl Mater Interfaces. 2009 Aug; 1(8):1755-62. PMID: 20355792.
      View in: PubMed
    127. Muthana S, Yu H, Cao H, Cheng J, Chen X. Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. J Org Chem. 2009 Apr 17; 74(8):2928-36. PMID: 19296596.
      View in: PubMed
    128. Yi W, Liu X, Li Y, Li J, Xia C, Zhou G, Zhang W, Zhao W, Chen X, Wang PG. Remodeling bacterial polysaccharides by metabolic pathway engineering. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4207-12. PMID: 19251666.
      View in: PubMed
    129. Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS One. 2009; 4(1):e4241. PMID: 19156207.
      View in: PubMed
    130. Wong JH, Sahni U, Li Y, Chen X, Gervay-Hague J. Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors. Org Biomol Chem. 2009 Jan 07; 7(1):27-9. PMID: 19081938.
      View in: PubMed
    131. Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 2008 Dec 04; 456(7222):648-52. PMID: 18971931.
      View in: PubMed
    132. Chokhawala HA, Huang S, Lau K, Yu H, Cheng J, Thon V, Hurtado-Ziola N, Guerrero JA, Varki A, Chen X. Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. ACS Chem Biol. 2008 Sep 19; 3(9):567-76. PMID: 18729452.
      View in: PubMed
    133. Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 2008 Oct; 18(10):818-30. PMID: 18669916.
      View in: PubMed
    134. Cao H, Huang S, Cheng J, Li Y, Muthana S, Son B, Chen X. Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block. Carbohydr Res. 2008 Nov 24; 343(17):2863-9. PMID: 18639240.
      View in: PubMed
    135. Li Y, Yu H, Cao H, Lau K, Muthana S, Tiwari VK, Son B, Chen X. Pasteurella multocida sialic acid aldolase: a promising biocatalyst. Appl Microbiol Biotechnol. 2008 Jul; 79(6):963-70. PMID: 18521592.
      View in: PubMed
    136. Cheng J, Yu H, Lau K, Huang S, Chokhawala HA, Li Y, Tiwari VK, Chen X. Multifunctionality of Campylobacter jejuni sialyltransferase CstII: characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities. Glycobiology. 2008 Sep; 18(9):686-97. PMID: 18509108.
      View in: PubMed
    137. Linman MJ, Taylor JD, Yu H, Chen X, Cheng Q. Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides. Anal Chem. 2008 Jun 01; 80(11):4007-13. PMID: 18461973.
      View in: PubMed
    138. Sun M, Li Y, Chokhawala HA, Henning R, Chen X. N-Terminal 112 amino acid residues are not required for the sialyltransferase activity of Photobacterium damsela alpha2,6-sialyltransferase. Biotechnol Lett. 2008 Apr; 30(4):671-6. PMID: 17989925.
      View in: PubMed
    139. Muthana S, Yu H, Huang S, Chen X. Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides. J Am Chem Soc. 2007 Oct 03; 129(39):11918-9. PMID: 17845050.
      View in: PubMed
    140. Chokhawala HA, Cao H, Yu H, Chen X. Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases. J Am Chem Soc. 2007 Sep 05; 129(35):10630-1. PMID: 17696347.
      View in: PubMed
    141. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. PMID: 17646166.
      View in: PubMed
    142. Li Y, Sun M, Huang S, Yu H, Chokhawala HA, Thon V, Chen X. The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):555-60. PMID: 17662691.
      View in: PubMed
    143. Yu H, Chokhawala HA, Varki A, Chen X. Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Org Biomol Chem. 2007 Aug 07; 5(15):2458-63. PMID: 17637967.
      View in: PubMed
    144. Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29; 46(21):6288-98. PMID: 17487984.
      View in: PubMed
    145. Yu H, Chen X. Carbohydrate post-glycosylational modifications. Org Biomol Chem. 2007 Mar 21; 5(6):865-72. PMID: 17340000.
      View in: PubMed
    146. Chokhawala HA, Yu H, Chen X. High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries. Chembiochem. 2007 Jan 22; 8(2):194-201. PMID: 17195254.
      View in: PubMed
    147. Huang S, Yu H, Chen X. Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew Chem Int Ed Engl. 2007; 46(13):2249-53. PMID: 17309109.
      View in: PubMed
    148. Yu H, Huang S, Chokhawala H, Sun M, Zheng H, Chen X. Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity. Angew Chem Int Ed Engl. 2006 Jun 12; 45(24):3938-44. PMID: 16721893.
      View in: PubMed
    149. Yu H, Chen X. Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases. Org Lett. 2006 May 25; 8(11):2393-6. PMID: 16706534.
      View in: PubMed
    150. Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21; 45(7):2139-48. PMID: 16475803.
      View in: PubMed
    151. Yu H, Chokhawala HA, Huang S, Chen X. One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. Nat Protoc. 2006; 1(5):2485-92. PMID: 17406495.
      View in: PubMed
    152. Yu H, Ryan W, Yu H, Chen X. Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae. Biotechnol Lett. 2006 Jan; 28(2):107-13. PMID: 16369694.
      View in: PubMed
    153. Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, Chen X. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005 Dec 21; 127(50):17618-9. PMID: 16351087.
      View in: PubMed
    154. Yu H, Yu H, Karpel R, Chen X. Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases. Bioorg Med Chem. 2004 Dec 15; 12(24):6427-35. PMID: 15556760.
      View in: PubMed
    155. Saribas AS, Mobasseri A, Pristatsky P, Chen X, Barthelson R, Hakes D, Wang J. Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1). Glycobiology. 2004 Dec; 14(12):1217-28. PMID: 15253930.
      View in: PubMed
    156. Zhang J, Kowal P, Chen X, Wang PG. Large-scale synthesis of globotriose derivatives through recombinant E. coli. Org Biomol Chem. 2003 Sep 07; 1(17):3048-53. PMID: 14518127.
      View in: PubMed
    157. Chen X, Wu B, Wang PG. Glucuronides in anti-cancer therapy. Curr Med Chem Anticancer Agents. 2003 Mar; 3(2):139-50. PMID: 12678908.
      View in: PubMed
    158. Nahalka J, Liu Z, Chen X, Wang PG. Superbeads: immobilization in "sweet" chemistry. Chemistry. 2003 Jan 20; 9(2):372-7. PMID: 12532285.
      View in: PubMed
    159. Zhang J, Chen X, Shao J, Liu Z, Kowal P, Lu Y, Wang PG. Synthesis of galactose-containing oligosaccharides through superbeads and superbug approaches: substrate recognition along different biosynthetic pathways. Methods Enzymol. 2003; 362:106-24. PMID: 12968360.
      View in: PubMed
    160. Chen Y, Janczuk A, Chen X, Wang J, Ksebati M, Wang PG. Expeditious syntheses of two carbohydrate-linked cisplatin analogs. Carbohydr Res. 2002 Jun 05; 337(11):1043-6. PMID: 12039546.
      View in: PubMed
    161. Liu Z, Zhang J, Chen X, Wang PG. Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads. Chembiochem. 2002 Apr 02; 3(4):348-55. PMID: 11933236.
      View in: PubMed
    162. Chen X, Liu Z, Zhang J, Zhang W, Kowal P, Wang PG. Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug". Chembiochem. 2002 Jan 04; 3(1):47-53. PMID: 17590953.
      View in: PubMed
    163. Chen X, Zhang J, Kowal P, Liu Z, Andreana PR, Lu Y, Wang PG. Transferring a biosynthetic cycle into a productive Escherichia coli strain: large-scale synthesis of galactosides. J Am Chem Soc. 2001 Sep 12; 123(36):8866-7. PMID: 11535100.
      View in: PubMed
    164. Chen X, Wen Z, Xian M, Wang K, Ramachandran N, Tang X, Schlegel HB, Mutus B, Wang PG. Fluorophore-labeled S-nitrosothiols. J Org Chem. 2001 Sep 07; 66(18):6064-73. PMID: 11529732.
      View in: PubMed
    165. Chen X, Fang J, Zhang J, Liu Z, Shao J, Kowal P, Andreana P, Wang PG. Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides. J Am Chem Soc. 2001 Mar 07; 123(9):2081-2. PMID: 11456841.
      View in: PubMed
    166. Fang J, Chen X, Zhang W, Janczuk A, Wang PG. Synthesis of alpha-Gal epitope derivatives with a galactosyltransferase-epimerase fusion enzyme. Carbohydr Res. 2000 Dec 01; 329(4):873-8. PMID: 11125830.
      View in: PubMed
    167. Chen X, Kowal P, Wang PG. Large-scale enzymatic synthesis of oligosaccharides. Curr Opin Drug Discov Devel. 2000 Nov; 3(6):756-63. PMID: 19649904.
      View in: PubMed
    168. Chen X, Liu Z, Wang J, Fang J, Fan H, Wang PG. Changing the donor cofactor of bovine alpha 1, 3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of alpha-Gal epitopes. J Biol Chem. 2000 Oct 13; 275(41):31594-600. PMID: 10913140.
      View in: PubMed
    169. Chen X, Zhang W, Wang J, Fang J, Wang PG. Production of alpha-galactosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and alpha-1,3-galactosyltransferase. Biotechnol Prog. 2000 Jul-Aug; 16(4):595-9. PMID: 10933834.
      View in: PubMed
    170. Xian M, Wang K, Chen X, Hou Y, McGill A, Zhou B, Zhang ZY, Cheng JP, Wang PG. Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin. Biochem Biophys Res Commun. 2000 Feb 16; 268(2):310-4. PMID: 10679200.
      View in: PubMed
    171. Chen X, Andreana PR, Wang PG. Carbohydrates in transplantation. Curr Opin Chem Biol. 1999 Dec; 3(6):650-8. PMID: 10600719.
      View in: PubMed
    172. Li J, Zacharek S, Chen X, Wang J, Zhang W, Janczuk A, Wang PG. Bacteria targeted by human natural antibodies using alpha-Gal conjugated receptor-specific glycopolymers. Bioorg Med Chem. 1999 Aug; 7(8):1549-58. PMID: 10482447.
      View in: PubMed
    173. Janczuk A, Li J, Zhang W, Chen X, Chen Y, Fang J, Wang J, Wang PG. Alpha-Gal oligosaccharides: chemistry and potential biomedical application. Curr Med Chem. 1999 Feb; 6(2):155-64. PMID: 10189229.
      View in: PubMed