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Xi Chen, PhD

Title(s)Professor, Chemistry
SchoolUniversity of California, Davis
Phone530-754-6037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McArthur JB, Santra A, Li W, Kooner AS, Liu Z, Yu H, Chen X. L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues. Org Biomol Chem. 2020 01 28; 18(4):738-744. PMID: 31912849.
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    2. Li Y, Li R, Yu H, Sheng X, Wang J, Fisher AJ, Chen X. Enterococcus faecalis a1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS Lett. 2020 Feb; 594(3):439-451. PMID: 31552675.
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    3. Matthews MM, McArthur JB, Li Y, Yu H, Chen X, Fisher AJ. Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry. 2019 Oct 04. PMID: 31583886.
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    4. Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Arye S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP. Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation. 2019 Nov; 26(6):e12535. PMID: 31293002.
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    5. Leviatan Ben-Arye S, Schneider C, Yu H, Bashir S, Chen X, von Gunten S, Padler-Karavani V. Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies. Bioconjug Chem. 2019 05 15; 30(5):1565-1574. PMID: 30994337.
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    6. Reuven EM, Leviatan Ben-Arye S, Yu H, Duchi R, Perota A, Conchon S, Bachar Abramovitch S, Soulillou JP, Galli C, Chen X, Padler-Karavani V. Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy. ACS Nano. 2019 Mar 26; 13(3):2936-2947. PMID: 30840433.
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    7. Rousse J, Salama A, Leviatan Ben-Arye S, Hruba P, Slatinska J, Evanno G, Duvaux O, Blanchard D, Yu H, Chen X, Bach JM, Padler-Karavani V, Viklicky O, Soulillou JP. Quantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients. Eur J Clin Invest. 2019 Apr; 49(4):e13069. PMID: 30620396.
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    8. Li S, Wang J, Zang L, Zhu H, Guo J, Zhang J, Wen L, Chen Y, Li Y, Chen X, Wang PG, Li J. Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. Front Chem. 2018; 6:646. PMID: 30693278.
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    9. Yuen PK, Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS. Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry. ACS Chem Biol. 2019 01 18; 14(1):27-36. PMID: 30500207.
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    10. Bashir S, Leviatan Ben Arye S, Reuven EM, Yu H, Costa C, Galiñanes M, Bottio T, Chen X, Padler-Karavani V. Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies. Bioconjug Chem. 2019 01 16; 30(1):161-168. PMID: 30500162.
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    11. Tasnima N, Yu H, Yan X, Li W, Xiao A, Chen X. Facile chemoenzymatic synthesis of Lewis a (Lea) antigen in gram-scale and sialyl Lewis a (sLea) antigens containing diverse sialic acid forms. Carbohydr Res. 2019 Jan 15; 472:115-121. PMID: 30562693.
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    12. Santra A, Li Y, Ghosh T, Li R, Yu H, Chen X. Regioselective One-Pot Multienzyme (OPME) Chemoenzymatic Strategies for Systematic Synthesis of Sialyl Core 2 Glycans. ACS Catal. 2019 Jan 04; 9(1):211-215. PMID: 31304048.
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    13. Li W, McArthur JB, Chen X. Strategies for chemoenzymatic synthesis of carbohydrates. Carbohydr Res. 2019 Jan 15; 472:86-97. PMID: 30529493.
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    14. Slack TJ, Li W, Shi D, McArthur JB, Zhao G, Li Y, Xiao A, Khedri Z, Yu H, Liu Y, Chen X. Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem. 2018 11 15; 26(21):5751-5757. PMID: 30389408.
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    15. Xiao A, Slack TJ, Li Y, Shi D, Yu H, Li W, Liu Y, Chen X. Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic Acids as Selective Sialidase Inhibitors. J Org Chem. 2018 09 21; 83(18):10798-10804. PMID: 30105908.
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    16. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. PMID: 29912959.
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    17. Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, Varki A. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PLoS One. 2018; 13(6):e0197464. PMID: 29912879.
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    18. Yu H, Santra A, Li Y, McArthur JB, Ghosh T, Yang X, Wang PG, Chen X. Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens. Org Biomol Chem. 2018 06 06; 16(22):4076-4080. PMID: 29789847.
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    19. Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 06; 86(6). PMID: 29581195.
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    20. McArthur JB, Yu H, Tasnima N, Lee CM, Fisher AJ, Chen X. a2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase. ACS Chem Biol. 2018 05 18; 13(5):1228-1234. PMID: 29543427.
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    21. Mai HL, Treilhaud M, Ben-Arye SL, Yu H, Perreault H, Ang E, Trébern-Launay K, Laurent J, Malard-Castagnet S, Cesbron A, Nguyen TVH, Brouard S, Rostaing L, Houssel-Debry P, Legendre C, Girerd S, Kessler M, Morelon E, Sicard A, Garrigue V, Karam G, Chen X, Giral M, Padler-Karavani V, Soulillou JP. Poor Patient and Graft Outcome After Induction Treatment by Antithymocyte Globulin in Recipients of a Kidney Graft After Nonrenal Organ Transplantation. Transplant Direct. 2018 Apr; 4(4):e357. PMID: 29707628.
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    22. Santra A, Xiao A, Yu H, Li W, Li Y, Ngo L, McArthur JB, Chen X. A Diazido Mannose Analogue as a Chemoenzymatic Synthon for Synthesizing Di-N-acetyllegionaminic Acid-Containing Glycosides. Angew Chem Int Ed Engl. 2018 03 05; 57(11):2929-2933. PMID: 29349857.
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    23. Ming SA, Cottman-Thomas E, Black NC, Chen Y, Veeramachineni V, Peterson DC, Chen X, Tedaldi LM, Wagner GK, Cai C, Linhardt RJ, Vann WF. Interaction of Neisseria meningitidis Group X N-acetylglucosamine-1-phosphotransferase with its donor substrate. Glycobiology. 2018 02 01; 28(2):100-107. PMID: 29228283.
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    24. Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun. 2017 12 19; 8(1):2196. PMID: 29259165.
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    25. Amon R, Ben-Arye SL, Engler L, Yu H, Lim N, Berre LL, Harris KM, Ehlers MR, Gitelman SE, Chen X, Soulillou JP, Padler-Karavani V. Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy. Oncotarget. 2017 Dec 22; 8(68):112236-112244. PMID: 29348821.
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    26. Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. BMC Evol Biol. 2017 11 23; 17(1):228. PMID: 29169316.
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    27. Yu H, Yan X, Autran CA, Li Y, Etzold S, Latasiewicz J, Robertson BM, Li J, Bode L, Chen X. Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects. J Org Chem. 2017 12 15; 82(24):13152-13160. PMID: 29124935.
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    28. Xiao A, Li Y, Li X, Santra A, Yu H, Li W, Chen X. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018 Jan 05; 8(1):43-47. PMID: 29713561.
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    29. Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol. 2017 Dec; 2(12):1592-1599. PMID: 28993610.
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    30. Yu H, Li Y, Wu Z, Li L, Zeng J, Zhao C, Wu Y, Tasnima N, Wang J, Liu H, Gadi MR, Guan W, Wang PG, Chen X. H. pylori a1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides. Chem Commun (Camb). 2017 Oct 05; 53(80):11012-11015. PMID: 28936496.
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    31. Li W, Xiao A, Li Y, Yu H, Chen X. Chemoenzymatic synthesis of Neu5Ac9NAc-containing a2-3- and a2-6-linked sialosides and their use for sialidase substrate specificity studies. Carbohydr Res. 2017 Nov 08; 451:51-58. PMID: 28961426.
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    32. Wasik BR, Barnard KN, Ossiboff RJ, Khedri Z, Feng KH, Yu H, Chen X, Perez DR, Varki A, Parrish CR. Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. mSphere. 2017 Sep-Oct; 2(5). PMID: 28904995.
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    33. Monestier M, Latousakis D, Bell A, Tribolo S, Tailford LE, Colquhoun IJ, Le Gall G, Yu H, Chen X, Rejzek M, Dedola S, Field RA, Juge N. Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives. Carbohydr Res. 2017 Nov 08; 451:110-117. PMID: 28851488.
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    34. Cámara MLM, Cánepa GE, Lantos AB, Balouz V, Yu H, Chen X, Campetella O, Mucci J, Buscaglia CA. The Trypomastigote Small Surface Antigen (TSSA) regulates Trypanosoma cruzi infectivity and differentiation. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005856. PMID: 28800609.
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    35. Santra A, Li Y, Yu H, Slack TJ, Wang PG, Chen X. Highly efficient chemoenzymatic synthesis and facile purification of a-Gal pentasaccharyl ceramide Gala3nLc4ßCer. Chem Commun (Camb). 2017 Jul 20; 53(59):8280-8283. PMID: 28695219.
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    36. Leviatan Ben-Arye S, Yu H, Chen X, Padler-Karavani V. Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay. J Vis Exp. 2017 07 13; (125). PMID: 28745644.
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    37. Fu X, Shang W, Wang S, Liu Y, Qu J, Chen X, Wang PG, Fang J. A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. Chem Commun (Camb). 2017 Mar 23; 53(25):3555-3558. PMID: 28286894.
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    38. McArthur JB, Yu H, Zeng J, Chen X. Converting Pasteurella multocidaa2-3-sialyltransferase 1 (PmST1) to a regioselective a2-6-sialyltransferase by saturation mutagenesis and regioselective screening. Org Biomol Chem. 2017 Feb 21; 15(7):1700-1709. PMID: 28134951.
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    39. Tasnima N, Yu H, Li Y, Santra A, Chen X. Chemoenzymatic synthesis of para-nitrophenol (pNP)-tagged a2-8-sialosides and high-throughput substrate specificity studies of a2-8-sialidases. Org Biomol Chem. 2016 Dec 20; 15(1):160-167. PMID: 27924345.
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    40. Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X. A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids. ACS Chem Biol. 2017 01 20; 12(1):214-224. PMID: 27936566.
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    41. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E. J Biol Chem. 2017 01 20; 292(3):1029-1037. PMID: 27920204.
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    42. Tsering D, Chen C, Ye J, Han Z, Jing BQ, Liu XW, Chen X, Wang F, Ling P, Cao H. Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr Res. 2017 Jan 13; 438:39-43. PMID: 27960098.
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    43. Jinfeng Ye, Xian-wei Liu, Peng Peng, Wen Yi, Xi Chen, Fengshan Wang, Hongzhi Cao. Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens. ACS Catalysis. 2016 Dec 2; 6(12):8140-8144.
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    44. Wu Z, Liu Y, Ma C, Li L, Bai J, Byrd-Leotis L, Lasanajak Y, Guo Y, Wen L, Zhu H, Song J, Li Y, Steinhauer DA, Smith DF, Zhao B, Chen X, Guan W, Wang PG. Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes. Org Biomol Chem. 2016 Nov 29; 14(47):11106-11116. PMID: 27752690.
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    45. Zhipeng Han, Congcong Chen, Caicai Meng, Tian Gao, Peng Peng, Xi Chen, Fengshan Wang, Hongzhi Cao. Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. Journal of Carbohydrate Chemistry. 2016 Nov 21; 35(8-9):1-11.
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    46. Yu H, Li Y, Zeng J, Thon V, Nguyen DM, Ly T, Kuang HY, Ngo A, Chen X. Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans. J Org Chem. 2016 11 18; 81(22):10809-10824. PMID: 27736072.
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    47. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 25; 55(42):5927-5937. PMID: 27685666.
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    48. Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415. PMID: 27689936.
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    49. Reuven EM, Leviatan Ben-Arye S, Marshanski T, Breimer ME, Yu H, Fellah-Hebia I, Roussel JC, Costa C, Galiñanes M, Mañez R, Le Tourneau T, Soulillou JP, Cozzi E, Chen X, Padler-Karavani V. Characterization of immunogenic Neu5Gc in bioprosthetic heart valves. Xenotransplantation. 2016 09; 23(5):381-92. PMID: 27610947.
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    50. Yu H, Zeng J, Li Y, Thon V, Shi B, Chen X. Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid. Org Biomol Chem. 2016 Sep 28; 14(36):8586-97. PMID: 27548611.
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    51. Liu Y, Wen L, Li L, Gadi MR, Guan W, Huang K, Xiao Z, Wei M, Ma C, Zhang Q, Yu H, Chen X, Wang PG, Fang J. A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids. European J Org Chem. 2016 Sep; 2016(25):4315-4320. PMID: 28824290.
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    52. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. Correction: Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 May 21; 14(19):4542. PMID: 27139574.
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    53. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 Apr 26; 14(17):4027-31. PMID: 27080952.
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    54. Lantos AB, Carlevaro G, Araoz B, Ruiz Diaz P, Camara Mde L, Buscaglia CA, Bossi M, Yu H, Chen X, Bertozzi CR, Mucci J, Campetella O. Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. PLoS Pathog. 2016 Apr; 12(4):e1005559. PMID: 27058585.
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    55. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. PMID: 27037304.
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    56. Yu H, Chen X. One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates. Org Biomol Chem. 2016 Mar 14; 14(10):2809-18. PMID: 26881499.
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    57. Li Y, Xue M, Sheng X, Yu H, Zeng J, Thon V, Chen Y, Muthana MM, Wang PG, Chen X. Donor substrate promiscuity of bacterial ß1-3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of ß1-4-galactosyltransferases. Bioorg Med Chem. 2016 Apr 15; 24(8):1696-705. PMID: 26968649.
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    58. Zhao C, Wu Y, Yu H, Shah IM, Li Y, Zeng J, Liu B, Mills DA, Chen X. The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates a1-2-fucosyltransferase. Chem Commun (Camb). 2016 Mar 11; 52(20):3899-902. PMID: 26864394.
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    59. McArthur JB, Chen X. Glycosyltransferase engineering for carbohydrate synthesis. Biochem Soc Trans. 2016 Feb; 44(1):129-42. PMID: 26862198.
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    60. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem. 2016 Apr 01; 291(14):7230-40. PMID: 26833566.
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    61. Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLoS Pathog. 2016 Jan; 12(1):e1005411. PMID: 26816272.
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    62. Tiwari VK, Mishra BB, Mishra KB, Mishra N, Singh AS, Chen X. Cu-Catalyzed Click Reaction in Carbohydrate Chemistry. Chem Rev. 2016 Mar 09; 116(5):3086-240. PMID: 26796328.
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    63. Santra A, Yu H, Tasnima N, Muthana MM, Li Y, Zeng J, Kenyond NJ, Louie AY, Chen X. Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. Chem Sci. 2016 Apr 01; 7(4):2827-2831. PMID: 28138383.
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    64. Chen X. Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis. Adv Carbohydr Chem Biochem. 2015; 72:113-90. PMID: 26613816.
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    65. Zhang L, Muthana MM, Yu H, McArthur JB, Qu J, Chen X. Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives. Carbohydr Res. 2016 Jan; 419:18-28. PMID: 26598987.
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    66. Fei Y, Sun YS, Li Y, Yu H, Lau K, Landry JP, Luo Z, Baumgarth N, Chen X, Zhu X. Characterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform. Biomolecules. 2015 Jul 16; 5(3):1480-98. PMID: 26193329.
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    67. Li L, Liu Y, Li T, Wang W, Yu Z, Ma C, Qu J, Zhao W, Chen X, Wang PG. Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. Chem Commun (Camb). 2015 Jun 28; 51(51):10310-3. PMID: 26023910.
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    68. Zhang Y, Meng C, Jin L, Chen X, Wang F, Cao H. Chemoenzymatic synthesis of a-dystroglycan core M1 O-mannose glycans. Chem Commun (Camb). 2015 Jul 25; 51(58):11654-7. PMID: 26100261.
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    69. Li L, Liu Y, Ma C, Qu J, Calderon AD, Wu B, Wei N, Wang X, Guo Y, Xiao Z, Song J, Sugiarto G, Li Y, Yu H, Chen X, Wang PG. Efficient Chemoenzymatic Synthesis of an N-glycan Isomer Library. Chem Sci. 2015 Oct 01; 6(10):5652-5661. PMID: 26417422.
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    70. Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ. Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Rep. 2015 Jun 30; 11(12):1966-78. PMID: 26095364.
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    71. Wu B, Wei N, Thon V, Wei M, Yu Z, Xu Y, Chen X, Liu J, Wang PG, Li T. Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. Org Biomol Chem. 2015 May 14; 13(18):5098-101. PMID: 25858766.
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    72. Chen C, Zhang Y, Xue M, Liu XW, Li Y, Chen X, Wang PG, Wang F, Cao H. Sequential one-pot multienzyme (OPME) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives. Chem Commun (Camb). 2015 May 04; 51(36):7689-92. PMID: 25848722.
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    73. Ngo A, Fong KT, Cox DL, Chen X, Fisher AJ. Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Crystallogr D Biol Crystallogr. 2015 May; 71(Pt 5):1068-76. PMID: 25945572.
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    74. Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. J Virol. 2015 Jul; 89(13):6860-73. PMID: 25903329.
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    75. Muthana MM, Qu J, Xue M, Klyuchnik T, Siu A, Li Y, Zhang L, Yu H, Li L, Wang PG, Chen X. Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides. Chem Commun (Camb). 2015 Mar 18; 51(22):4595-8. PMID: 25686901.
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    76. Peralta MD, Karsai A, Ngo A, Sierra C, Fong KT, Hayre NR, Mirzaee N, Ravikumar KM, Kluber AJ, Chen X, Liu GY, Toney MD, Singh RR, Cox DL. Engineering amyloid fibrils from ß-solenoid proteins for biomaterials applications. ACS Nano. 2015 Jan 27; 9(1):449-63. PMID: 25562726.
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    77. Ding L, Zhao C, Qu J, Li Y, Sugiarto G, Yu H, Wang J, Chen X. A Photobacterium sp. a2-6-sialyltransferase (Psp2,6ST) mutant with an increased expression level and improved activities in sialylating Tn antigens. Carbohydr Res. 2015 May 18; 408:127-33. PMID: 25593075.
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    78. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 2014 Dec 04; 159(6):1290-9. PMID: 25480294.
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    166. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. PMID: 17646166.
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    167. Li Y, Sun M, Huang S, Yu H, Chokhawala HA, Thon V, Chen X. The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):555-60. PMID: 17662691.
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    168. Yu H, Chokhawala HA, Varki A, Chen X. Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Org Biomol Chem. 2007 Aug 07; 5(15):2458-63. PMID: 17637967.
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    169. Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29; 46(21):6288-98. PMID: 17487984.
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    170. Yu H, Chen X. Carbohydrate post-glycosylational modifications. Org Biomol Chem. 2007 Mar 21; 5(6):865-72. PMID: 17340000.
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    171. Chokhawala HA, Yu H, Chen X. High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries. Chembiochem. 2007 Jan 22; 8(2):194-201. PMID: 17195254.
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    172. Huang S, Yu H, Chen X. Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew Chem Int Ed Engl. 2007; 46(13):2249-53. PMID: 17309109.
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    173. Yu H, Huang S, Chokhawala H, Sun M, Zheng H, Chen X. Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity. Angew Chem Int Ed Engl. 2006 Jun 12; 45(24):3938-44. PMID: 16721893.
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    174. Yu H, Chen X. Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases. Org Lett. 2006 May 25; 8(11):2393-6. PMID: 16706534.
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    175. Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21; 45(7):2139-48. PMID: 16475803.
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    176. Yu H, Chokhawala HA, Huang S, Chen X. One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. Nat Protoc. 2006; 1(5):2485-92. PMID: 17406495.
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    177. Yu H, Ryan W, Yu H, Chen X. Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae. Biotechnol Lett. 2006 Jan; 28(2):107-13. PMID: 16369694.
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    178. Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, Chen X. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005 Dec 21; 127(50):17618-9. PMID: 16351087.
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    179. Yu H, Yu H, Karpel R, Chen X. Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases. Bioorg Med Chem. 2004 Dec 15; 12(24):6427-35. PMID: 15556760.
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    180. Saribas AS, Mobasseri A, Pristatsky P, Chen X, Barthelson R, Hakes D, Wang J. Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1). Glycobiology. 2004 Dec; 14(12):1217-28. PMID: 15253930.
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    181. Zhang J, Kowal P, Chen X, Wang PG. Large-scale synthesis of globotriose derivatives through recombinant E. coli. Org Biomol Chem. 2003 Sep 07; 1(17):3048-53. PMID: 14518127.
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    182. Chen X, Wu B, Wang PG. Glucuronides in anti-cancer therapy. Curr Med Chem Anticancer Agents. 2003 Mar; 3(2):139-50. PMID: 12678908.
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    183. Nahalka J, Liu Z, Chen X, Wang PG. Superbeads: immobilization in "sweet" chemistry. Chemistry. 2003 Jan 20; 9(2):372-7. PMID: 12532285.
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    184. Zhang J, Chen X, Shao J, Liu Z, Kowal P, Lu Y, Wang PG. Synthesis of galactose-containing oligosaccharides through superbeads and superbug approaches: substrate recognition along different biosynthetic pathways. Methods Enzymol. 2003; 362:106-24. PMID: 12968360.
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    185. Chen Y, Janczuk A, Chen X, Wang J, Ksebati M, Wang PG. Expeditious syntheses of two carbohydrate-linked cisplatin analogs. Carbohydr Res. 2002 Jun 05; 337(11):1043-6. PMID: 12039546.
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    186. Liu Z, Zhang J, Chen X, Wang PG. Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads. Chembiochem. 2002 Apr 02; 3(4):348-55. PMID: 11933236.
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    187. Chen X, Liu Z, Zhang J, Zhang W, Kowal P, Wang PG. Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug". Chembiochem. 2002 Jan 04; 3(1):47-53. PMID: 17590953.
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    188. Jianbo Zhang, Bingyuan Wu, Ziye Liu, Premzek Kowal, Xi Chen, Jun Shao, Peng Wang. Large-scale Synthesis of Carbohydrates for Pharmaceutical Development. Current Organic Chemistry. 2001 Dec 1; 5(12):1169-1176.
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    189. Chen X, Zhang J, Kowal P, Liu Z, Andreana PR, Lu Y, Wang PG. Transferring a biosynthetic cycle into a productive Escherichia coli strain: large-scale synthesis of galactosides. J Am Chem Soc. 2001 Sep 12; 123(36):8866-7. PMID: 11535100.
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    190. Chen X, Wen Z, Xian M, Wang K, Ramachandran N, Tang X, Schlegel HB, Mutus B, Wang PG. Fluorophore-labeled S-nitrosothiols. J Org Chem. 2001 Sep 07; 66(18):6064-73. PMID: 11529732.
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    191. Chen X, Fang J, Zhang J, Liu Z, Shao J, Kowal P, Andreana P, Wang PG. Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides. J Am Chem Soc. 2001 Mar 07; 123(9):2081-2. PMID: 11456841.
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    192. Fang J, Chen X, Zhang W, Janczuk A, Wang PG. Synthesis of alpha-Gal epitope derivatives with a galactosyltransferase-epimerase fusion enzyme. Carbohydr Res. 2000 Dec 01; 329(4):873-8. PMID: 11125830.
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    193. Chen X, Kowal P, Wang PG. Large-scale enzymatic synthesis of oligosaccharides. Curr Opin Drug Discov Devel. 2000 Nov; 3(6):756-63. PMID: 19649904.
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    194. Chen X, Liu Z, Wang J, Fang J, Fan H, Wang PG. Changing the donor cofactor of bovine alpha 1, 3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of alpha-Gal epitopes. J Biol Chem. 2000 Oct 13; 275(41):31594-600. PMID: 10913140.
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    195. Chen X, Zhang W, Wang J, Fang J, Wang PG. Production of alpha-galactosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and alpha-1,3-galactosyltransferase. Biotechnol Prog. 2000 Jul-Aug; 16(4):595-9. PMID: 10933834.
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    196. Xian M, Wang K, Chen X, Hou Y, McGill A, Zhou B, Zhang ZY, Cheng JP, Wang PG. Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin. Biochem Biophys Res Commun. 2000 Feb 16; 268(2):310-4. PMID: 10679200.
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    197. Xi Chen, Przemyslaw Kowal, Sarah Hamad, Hongni Fan, Peng George Wang. Cloning, expression and characterization of a UDP-galactose 4-epimerase from Escherichia coli. Biotechnology Letters. 1999 Dec 1; 21(12):1131-1135.
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    198. Chen X, Andreana PR, Wang PG. Carbohydrates in transplantation. Curr Opin Chem Biol. 1999 Dec; 3(6):650-8. PMID: 10600719.
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    199. Jianq-Qiang Wang, Xi Chen, Wei Zhang, Sima Zacharek, Yongsheng Chen, Peng George Wang. Enhanced Inhibition of Human Anti-Gal Antibody Binding to Mammalian Cells by Synthetic a-Gal Epitope Polymers. Journal of the American Chemical Society. 1999 Sep 1; 121(36):8174-8181.
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    200. Li J, Zacharek S, Chen X, Wang J, Zhang W, Janczuk A, Wang PG. Bacteria targeted by human natural antibodies using alpha-Gal conjugated receptor-specific glycopolymers. Bioorg Med Chem. 1999 Aug; 7(8):1549-58. PMID: 10482447.
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    201. Jianwen Fang, Xi Chen, Wei Zhang, Jianqiang Wang, Peter R. Andreana, Peng George Wang. A Unique Chemoenzymatic Synthesis of a-Galactosyl Epitope Derivatives Containing Free Amino Groups:  Efficient Separation and Further Manipulation. The Journal of Organic Chemistry. 1999 May 1; 64(11):4089-4094.
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    202. Janczuk A, Li J, Zhang W, Chen X, Chen Y, Fang J, Wang J, Wang PG. Alpha-Gal oligosaccharides: chemistry and potential biomedical application. Curr Med Chem. 1999 Feb; 6(2):155-64. PMID: 10189229.
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    203. Jianwen Fang, Jun Li, Xi Chen, Yingnan Zhang, Jianqiang Wang, Zhengmao Guo, Wei Zhang, Libing Yu, Keith Brew, Peng George Wang. Highly Efficient Chemoenzymatic Synthesis of a-Galactosyl Epitopes with a Recombinant a(1?3)-Galactosyltransferase. Journal of the American Chemical Society. 1998 Jul 1; 120(27):6635-6638.
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