Xi Chen

Title(s)Professor, Chemistry
SchoolCollege of Letters and Sciences
Address212 Chemistry Bldg
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Chemoenzymatic synthesis of bacterial nonulosonic acids and glycans
    NIH R01GM141324Mar 5, 2021 - Jan 31, 2025
    Role: Principal Investigator
    2019 Carbohydrates Gordon Research Conference and Gordon Research Seminar
    NIH R13AI145089Feb 15, 2019 - Jul 31, 2019
    Role: Principal Investigator
    Exploring the biology of O-acetyl sialic acids using stable synthetic mimics
    NIH R01AI130684Sep 25, 2017 - Aug 31, 2021
    Role: Principal Investigator
    Facile chemoenzymatic synthesis and purification of glycolipids
    NIH U01GM120419Sep 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    New chemoenzymatic methods for synthesizing complex carbohydrates
    NIH R01GM094523Sep 20, 2013 - May 31, 2018
    Role: Principal Investigator
    Oligosaccharides as antimicrobials and prebiotics
    NIH R01HD065122Jul 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Chemical Glycobiology Symposium
    NIH R13AI073074Sep 11, 2006 - Aug 31, 2007
    Role: Principal Investigator
    Studies of naturally occurring structurally modified carbohydrates
    NIH R01GM076360Jan 1, 2006 - Dec 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues. Org Biomol Chem. 2020 01 28; 18(4):738-744. McArthur JB, Santra A, Li W, Kooner AS, Liu Z, Yu H, Chen X. PMID: 31912849; PMCID: PMC7098451.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    2. Enterococcus faecalis α1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS Lett. 2020 02; 594(3):439-451. Li Y, Li R, Yu H, Sheng X, Wang J, Fisher AJ, Chen X. PMID: 31552675; PMCID: PMC7012691.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    3. Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry. 2020 09 01; 59(34):3157-3168. Matthews MM, McArthur JB, Li Y, Yu H, Chen X, Fisher AJ. PMID: 31583886; PMCID: PMC7814854.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    4. Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. Front Immunol. 2019; 10:2004. Kooner AS, Yu H, Chen X. PMID: 31555264; PMCID: PMC6724515.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    5. Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation. 2019 11; 26(6):e12535. Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Arye S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP. PMID: 31293002.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. 9-Azido-9-deoxy-2,3-difluorosialic Acid as a Subnanomolar Inhibitor against Bacterial Sialidases. J Org Chem. 2019 06 07; 84(11):6697-6708. Li W, Santra A, Yu H, Slack TJ, Muthana MM, Shi D, Liu Y, Chen X. PMID: 31083938; PMCID: PMC6660241.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Biochemical characterization of Helicobacter pylori α1-3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides. Carbohydr Res. 2019 Jul 01; 480:1-6. Bai J, Wu Z, Sugiarto G, Gadi MR, Yu H, Li Y, Xiao C, Ngo A, Zhao B, Chen X, Guan W. PMID: 31132553; PMCID: PMC6613818.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. A substrate tagging and two-step enzymatic reaction strategy for large-scale synthesis of 2,7-anhydro-sialic acid. Carbohydr Res. 2019 Jun 01; 479:41-47. Li W, Ghosh T, Bai Y, Santra A, Xiao A, Chen X. PMID: 31132641; PMCID: PMC6660240.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies. Bioconjug Chem. 2019 05 15; 30(5):1565-1574. Leviatan Ben-Arye S, Schneider C, Yu H, Bashir S, Chen X, von Gunten S, Padler-Karavani V. PMID: 30994337; PMCID: PMC6756923.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy. ACS Nano. 2019 03 26; 13(3):2936-2947. Reuven EM, Leviatan Ben-Arye S, Yu H, Duchi R, Perota A, Conchon S, Bachar Abramovitch S, Soulillou JP, Galli C, Chen X, Padler-Karavani V. PMID: 30840433; PMCID: PMC6756924.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    11. Quantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients. Eur J Clin Invest. 2019 Apr; 49(4):e13069. Rousse J, Salama A, Leviatan Ben-Arye S, Hruba P, Slatinska J, Evanno G, Duvaux O, Blanchard D, Yu H, Chen X, Bach JM, Padler-Karavani V, Viklicky O, Soulillou JP. PMID: 30620396.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. Front Chem. 2018; 6:646. Li S, Wang J, Zang L, Zhu H, Guo J, Zhang J, Wen L, Chen Y, Li Y, Chen X, Wang PG, Li J. PMID: 30693278; PMCID: PMC6340312.
      View in: PubMed   Mentions: 4  
    13. Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry. ACS Chem Biol. 2019 01 18; 14(1):27-36. Yuen PK, Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS. PMID: 30500207; PMCID: PMC6825804.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies. Bioconjug Chem. 2019 01 16; 30(1):161-168. Bashir S, Leviatan Ben Arye S, Reuven EM, Yu H, Costa C, Galiñanes M, Bottio T, Chen X, Padler-Karavani V. PMID: 30500162; PMCID: PMC6768799.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    15. Facile chemoenzymatic synthesis of Lewis a (Lea) antigen in gram-scale and sialyl Lewis a (sLea) antigens containing diverse sialic acid forms. Carbohydr Res. 2019 Jan 15; 472:115-121. Tasnima N, Yu H, Yan X, Li W, Xiao A, Chen X. PMID: 30562693; PMCID: PMC6417886.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    16. Regioselective One-Pot Multienzyme (OPME) Chemoenzymatic Strategies for Systematic Synthesis of Sialyl Core 2 Glycans. ACS Catal. 2019 Jan 04; 9(1):211-215. Santra A, Li Y, Ghosh T, Li R, Yu H, Chen X. PMID: 31304048; PMCID: PMC6625783.
      View in: PubMed   Mentions: 3  
    17. Strategies for chemoenzymatic synthesis of carbohydrates. Carbohydr Res. 2019 Jan 15; 472:86-97. Li W, McArthur JB, Chen X. PMID: 30529493; PMCID: PMC6342554.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    18. Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem. 2018 11 15; 26(21):5751-5757. Slack TJ, Li W, Shi D, McArthur JB, Zhao G, Li Y, Xiao A, Khedri Z, Yu H, Liu Y, Chen X. PMID: 30389408; PMCID: PMC6326775.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic Acids as Selective Sialidase Inhibitors. J Org Chem. 2018 09 21; 83(18):10798-10804. Xiao A, Slack TJ, Li Y, Shi D, Yu H, Li W, Liu Y, Chen X. PMID: 30105908; PMCID: PMC6327951.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    20. A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. Sci Rep. 2018 Jul 17; 8(1):10786. Amon R, Grant OC, Leviatan Ben-Arye S, Makeneni S, Nivedha AK, Marshanski T, Norn C, Yu H, Glushka JN, Fleishman SJ, Chen X, Woods RJ, Padler-Karavani V. PMID: 30018351; PMCID: PMC6050261.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. PMID: 29912959; PMCID: PMC6023241.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    22. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PLoS One. 2018; 13(6):e0197464. Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, Varki A. PMID: 29912879; PMCID: PMC6005533.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    23. Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens. Org Biomol Chem. 2018 06 06; 16(22):4076-4080. Yu H, Santra A, Li Y, McArthur JB, Ghosh T, Yang X, Wang PG, Chen X. PMID: 29789847; PMCID: PMC5991974.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    24. Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 06; 86(6). Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. PMID: 29581195; PMCID: PMC5964516.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. α2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase. ACS Chem Biol. 2018 05 18; 13(5):1228-1234. McArthur JB, Yu H, Tasnima N, Lee CM, Fisher AJ, Chen X. PMID: 29543427; PMCID: PMC5978697.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    26. Poor Patient and Graft Outcome After Induction Treatment by Antithymocyte Globulin in Recipients of a Kidney Graft After Nonrenal Organ Transplantation. Transplant Direct. 2018 Apr; 4(4):e357. Mai HL, Treilhaud M, Ben-Arye SL, Yu H, Perreault H, Ang E, Trébern-Launay K, Laurent J, Malard-Castagnet S, Cesbron A, Nguyen TVH, Brouard S, Rostaing L, Houssel-Debry P, Legendre C, Girerd S, Kessler M, Morelon E, Sicard A, Garrigue V, Karam G, Chen X, Giral M, Padler-Karavani V, Soulillou JP. PMID: 29707628; PMCID: PMC5908458.
      View in: PubMed   Mentions: 6  
    27. A Diazido Mannose Analogue as a Chemoenzymatic Synthon for Synthesizing Di-N-acetyllegionaminic Acid-Containing Glycosides. Angew Chem Int Ed Engl. 2018 03 05; 57(11):2929-2933. Santra A, Xiao A, Yu H, Li W, Li Y, Ngo L, McArthur JB, Chen X. PMID: 29349857; PMCID: PMC5991975.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    28. Interaction of Neisseria meningitidis Group X N-acetylglucosamine-1-phosphotransferase with its donor substrate. Glycobiology. 2018 02 01; 28(2):100-107. Ming SA, Cottman-Thomas E, Black NC, Chen Y, Veeramachineni V, Peterson DC, Chen X, Tedaldi LM, Wagner GK, Cai C, Linhardt RJ, Vann WF. PMID: 29228283.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    29. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun. 2017 12 19; 8(1):2196. Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N. PMID: 29259165; PMCID: PMC5736709.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    30. Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy. Oncotarget. 2017 Dec 22; 8(68):112236-112244. Amon R, Ben-Arye SL, Engler L, Yu H, Lim N, Berre LL, Harris KM, Ehlers MR, Gitelman SE, Chen X, Soulillou JP, Padler-Karavani V. PMID: 29348821; PMCID: PMC5762506.
      View in: PubMed   Mentions: 20     Fields:    
    31. Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. BMC Evol Biol. 2017 11 23; 17(1):228. Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. PMID: 29169316; PMCID: PMC5701461.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    32. Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects. J Org Chem. 2017 12 15; 82(24):13152-13160. Yu H, Yan X, Autran CA, Li Y, Etzold S, Latasiewicz J, Robertson BM, Li J, Bode L, Chen X. PMID: 29124935; PMCID: PMC5764747.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    33. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018 Jan 05; 8(1):43-47. Xiao A, Li Y, Li X, Santra A, Yu H, Li W, Chen X. PMID: 29713561; PMCID: PMC5920526.
      View in: PubMed   Mentions: 7  
    34. Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol. 2017 Dec; 2(12):1592-1599. Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. PMID: 28993610; PMCID: PMC5705260.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    35. H. pylori α1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides. Chem Commun (Camb). 2017 Oct 05; 53(80):11012-11015. Yu H, Li Y, Wu Z, Li L, Zeng J, Zhao C, Wu Y, Tasnima N, Wang J, Liu H, Gadi MR, Guan W, Wang PG, Chen X. PMID: 28936496; PMCID: PMC5662472.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Chemoenzymatic synthesis of Neu5Ac9NAc-containing α2-3- and α2-6-linked sialosides and their use for sialidase substrate specificity studies. Carbohydr Res. 2017 Nov 08; 451:51-58. Li W, Xiao A, Li Y, Yu H, Chen X. PMID: 28961426; PMCID: PMC5662470.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    37. Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. mSphere. 2017 Sep-Oct; 2(5). Wasik BR, Barnard KN, Ossiboff RJ, Khedri Z, Feng KH, Yu H, Chen X, Perez DR, Varki A, Parrish CR. PMID: 28904995; PMCID: PMC5588038.
      View in: PubMed   Mentions: 40     Fields:    
    38. Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives. Carbohydr Res. 2017 Nov 08; 451:110-117. Monestier M, Latousakis D, Bell A, Tribolo S, Tailford LE, Colquhoun IJ, Le Gall G, Yu H, Chen X, Rejzek M, Dedola S, Field RA, Juge N. PMID: 28851488; PMCID: PMC5667892.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    39. The Trypomastigote Small Surface Antigen (TSSA) regulates Trypanosoma cruzi infectivity and differentiation. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005856. Cámara MLM, Cánepa GE, Lantos AB, Balouz V, Yu H, Chen X, Campetella O, Mucci J, Buscaglia CA. PMID: 28800609; PMCID: PMC5568413.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    40. Highly efficient chemoenzymatic synthesis and facile purification of α-Gal pentasaccharyl ceramide Galα3nLc4βCer. Chem Commun (Camb). 2017 Jul 20; 53(59):8280-8283. Santra A, Li Y, Yu H, Slack TJ, Wang PG, Chen X. PMID: 28695219; PMCID: PMC5597046.
      View in: PubMed   Mentions: 12     Fields:    
    41. Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay. J Vis Exp. 2017 07 13; (125). Leviatan Ben-Arye S, Yu H, Chen X, Padler-Karavani V. PMID: 28745644; PMCID: PMC5612302.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    42. A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. Chem Commun (Camb). 2017 Mar 23; 53(25):3555-3558. Fu X, Shang W, Wang S, Liu Y, Qu J, Chen X, Wang PG, Fang J. PMID: 28286894.
      View in: PubMed   Mentions: 4     Fields:    
    43. Converting Pasteurella multocidaα2-3-sialyltransferase 1 (PmST1) to a regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening. Org Biomol Chem. 2017 Feb 21; 15(7):1700-1709. McArthur JB, Yu H, Zeng J, Chen X. PMID: 28134951; PMCID: PMC5333693.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    44. Chemoenzymatic synthesis of para-nitrophenol (pNP)-tagged α2-8-sialosides and high-throughput substrate specificity studies of α2-8-sialidases. Org Biomol Chem. 2016 Dec 20; 15(1):160-167. Tasnima N, Yu H, Li Y, Santra A, Chen X. PMID: 27924345; PMCID: PMC5173422.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids. ACS Chem Biol. 2017 01 20; 12(1):214-224. Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X. PMID: 27936566; PMCID: PMC5704959.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    46. Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E. J Biol Chem. 2017 01 20; 292(3):1029-1037. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. PMID: 27920204; PMCID: PMC5247637.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    47. Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr Res. 2017 Jan 13; 438:39-43. Tsering D, Chen C, Ye J, Han Z, Jing BQ, Liu XW, Chen X, Wang F, Ling P, Cao H. PMID: 27960098.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    48. Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens. ACS Catalysis. 2016 Dec 2; 6(12):8140-8144. Ye YJ, Liu LX, Peng PP, Yi YW, Chen CX, Wang WF, Cao CH. .
      View in: Publisher Site   Mentions:
    49. Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes. Org Biomol Chem. 2016 Nov 29; 14(47):11106-11116. Wu Z, Liu Y, Ma C, Li L, Bai J, Byrd-Leotis L, Lasanajak Y, Guo Y, Wen L, Zhu H, Song J, Li Y, Steinhauer DA, Smith DF, Zhao B, Chen X, Guan W, Wang PG. PMID: 27752690; PMCID: PMC5951163.
      View in: PubMed   Mentions: 19     Fields:    
    50. Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. Journal of Carbohydrate Chemistry. 2016 Nov 21; 35(8-9):1-11. Han HZ, Chen CC, Meng MC, Gao GT, Peng PP, Chen CX, Wang WF, Cao CH. .
      View in: Publisher Site   Mentions:
    51. Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans. J Org Chem. 2016 11 18; 81(22):10809-10824. Yu H, Li Y, Zeng J, Thon V, Nguyen DM, Ly T, Kuang HY, Ngo A, Chen X. PMID: 27736072; PMCID: PMC5775905.
      View in: PubMed   Mentions: 26     Fields:    
    52. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 25; 55(42):5927-5937. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM. PMID: 27685666; PMCID: PMC5388602.
      View in: PubMed   Mentions: 17     Fields:    
    53. Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415. Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. PMID: 27689936.
      View in: PubMed   Mentions: 2     Fields:    
    54. Characterization of immunogenic Neu5Gc in bioprosthetic heart valves. Xenotransplantation. 2016 09; 23(5):381-92. Reuven EM, Leviatan Ben-Arye S, Marshanski T, Breimer ME, Yu H, Fellah-Hebia I, Roussel JC, Costa C, Galiñanes M, Mañez R, Le Tourneau T, Soulillou JP, Cozzi E, Chen X, Padler-Karavani V. PMID: 27610947; PMCID: PMC5036590.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    55. Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid. Org Biomol Chem. 2016 Sep 28; 14(36):8586-97. Yu H, Zeng J, Li Y, Thon V, Shi B, Chen X. PMID: 27548611; PMCID: PMC5036589.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    56. A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids. European J Org Chem. 2016 Sep; 2016(25):4315-4320. Liu Y, Wen L, Li L, Gadi MR, Guan W, Huang K, Xiao Z, Wei M, Ma C, Zhang Q, Yu H, Chen X, Wang PG, Fang J. PMID: 28824290; PMCID: PMC5560440.
      View in: PubMed   Mentions: 6  
    57. Correction: Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 May 21; 14(19):4542. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. PMID: 27139574.
      View in: PubMed   Mentions:    Fields:    
    58. Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 Apr 26; 14(17):4027-31. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. PMID: 27080952; PMCID: PMC4852481.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
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    132. Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 2011 May 01; 71(9):3352-63. Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. PMID: 21505105; PMCID: PMC3085609.
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    133. High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses. Virology. 2011 Jun 20; 415(1):12-9. Li Y, Cao H, Dao N, Luo Z, Yu H, Chen Y, Xing Z, Baumgarth N, Cardona C, Chen X. PMID: 21501853; PMCID: PMC3114948.
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    134. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol. 2011 May; 29(5):428-35. Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. PMID: 21478876; PMCID: PMC4090080.
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    135. Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives. Org Biomol Chem. 2011 Apr 21; 9(8):2784-9. Lau K, Yu H, Thon V, Khedri Z, Leon ME, Tran BK, Chen X. PMID: 21359399; PMCID: PMC3114947.
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    137. Fermenting next generation glycosylated therapeutics. ACS Chem Biol. 2011 Jan 21; 6(1):14-7. Chen X. PMID: 21250649.
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    138. Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies. Mol Biosyst. 2011 Apr; 7(4):1060-72. Li Y, Cao H, Yu H, Chen Y, Lau K, Qu J, Thon V, Sugiarto G, Chen X. PMID: 21206954; PMCID: PMC3114945.
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    139. Chemoenzymatic synthesis of α2-3-sialylated carbohydrate epitopes. Sci China Chem. 2011 Jan; 54(1):117-128. Shengshu H, Hai Y, Xi C. PMID: 21686057; PMCID: PMC3115702.
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    141. Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides. Chem Commun (Camb). 2010 Oct 28; 46(40):7507-9. Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X. PMID: 20830443; PMCID: PMC3114946.
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    144. Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family. Glycobiology. 2010 Sep; 20(9):1077-88. Zhang L, Lau K, Cheng J, Yu H, Li Y, Sugiarto G, Huang S, Ding L, Thon V, Wang PG, Chen X. PMID: 20466652; PMCID: PMC2948817.
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    145. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 2010 Jul; 20(7):833-42. Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, Bertozzi CR, Campetella O. PMID: 20354005; PMCID: PMC2900898.
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    147. Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J Am Chem Soc. 2009 Dec 30; 131(51):18467-77. Yu H, Cheng J, Ding L, Khedri Z, Chen Y, Chin S, Lau K, Tiwari VK, Chen X. PMID: 19947630; PMCID: PMC2811049.
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    148. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. PMID: 19828701; PMCID: PMC2792214.
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    149. Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides. Glycobiology. 2010 Feb; 20(2):260-8. Cheng J, Huang S, Yu H, Li Y, Lau K, Chen X. PMID: 19880425; PMCID: PMC2800248.
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    150. Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org Biomol Chem. 2009 Dec 21; 7(24):5137-45. Cao H, Li Y, Lau K, Muthana S, Yu H, Cheng J, Chokhawala HA, Sugiarto G, Zhang L, Chen X. PMID: 20024109.
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    151. Recent progress in chemical and chemoenzymatic synthesis of carbohydrates. Curr Opin Chem Biol. 2009 Dec; 13(5-6):573-81. Muthana S, Cao H, Chen X. PMID: 19833544; PMCID: PMC3097241.
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    153. Fabrication and characterization of a sialoside-based carbohydrate microarray biointerface for protein binding analysis with surface plasmon resonance imaging. ACS Appl Mater Interfaces. 2009 Aug; 1(8):1755-62. Linman MJ, Yu H, Chen X, Cheng Q. PMID: 20355792.
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    154. Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. J Org Chem. 2009 Apr 17; 74(8):2928-36. Muthana S, Yu H, Cao H, Cheng J, Chen X. PMID: 19296596.
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    155. Remodeling bacterial polysaccharides by metabolic pathway engineering. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4207-12. Yi W, Liu X, Li Y, Li J, Xia C, Zhou G, Zhang W, Zhao W, Chen X, Wang PG. PMID: 19251666; PMCID: PMC2657399.
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    156. Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS One. 2009; 4(1):e4241. Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM. PMID: 19156207; PMCID: PMC2626223.
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    158. Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 2008 Dec 04; 456(7222):648-52. Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. PMID: 18971931; PMCID: PMC2723748.
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    162. Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4. Adv Synth Catal. 2008 Aug 04; 350(11-12):1717-1728. Wang Z, Gilbert M, Eguchi H, Yu H, Cheng J, Muthana S, Zhou L, Wang PG, Chen X, Huang X. PMID: 20305750; PMCID: PMC2842016.
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    164. Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block. Carbohydr Res. 2008 Nov 24; 343(17):2863-9. Cao H, Huang S, Cheng J, Li Y, Muthana S, Son B, Chen X. PMID: 18639240; PMCID: PMC2783551.
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    165. Pasteurella multocida sialic acid aldolase: a promising biocatalyst. Appl Microbiol Biotechnol. 2008 Jul; 79(6):963-70. Li Y, Yu H, Cao H, Lau K, Muthana S, Tiwari VK, Son B, Chen X. PMID: 18521592; PMCID: PMC2588431.
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    166. Multifunctionality of Campylobacter jejuni sialyltransferase CstII: characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities. Glycobiology. 2008 Sep; 18(9):686-97. Cheng J, Yu H, Lau K, Huang S, Chokhawala HA, Li Y, Tiwari VK, Chen X. PMID: 18509108; PMCID: PMC2588429.
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    168. N-Terminal 112 amino acid residues are not required for the sialyltransferase activity of Photobacterium damsela alpha2,6-sialyltransferase. Biotechnol Lett. 2008 Apr; 30(4):671-6. Sun M, Li Y, Chokhawala HA, Henning R, Chen X. PMID: 17989925; PMCID: PMC2598773.
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    174. Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29; 46(21):6288-98. Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. PMID: 17487984.
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    175. Carbohydrate post-glycosylational modifications. Org Biomol Chem. 2007 Mar 21; 5(6):865-72. Yu H, Chen X. PMID: 17340000; PMCID: PMC2769254.
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    177. Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew Chem Int Ed Engl. 2007; 46(13):2249-53. Huang S, Yu H, Chen X. PMID: 17309109.
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    179. Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases. Org Lett. 2006 May 25; 8(11):2393-6. Yu H, Chen X. PMID: 16706534.
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    180. Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21; 45(7):2139-48. Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. PMID: 16475803.
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    181. One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. Nat Protoc. 2006; 1(5):2485-92. Yu H, Chokhawala HA, Huang S, Chen X. PMID: 17406495; PMCID: PMC2586341.
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    182. Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae. Biotechnol Lett. 2006 Jan; 28(2):107-13. Yu H, Ryan W, Yu H, Chen X. PMID: 16369694.
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    183. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005 Dec 21; 127(50):17618-9. Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, Chen X. PMID: 16351087.
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    185. Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1). Glycobiology. 2004 Dec; 14(12):1217-28. Saribas AS, Mobasseri A, Pristatsky P, Chen X, Barthelson R, Hakes D, Wang J. PMID: 15253930.
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    187. Glucuronides in anti-cancer therapy. Curr Med Chem Anticancer Agents. 2003 Mar; 3(2):139-50. Chen X, Wu B, Wang PG. PMID: 12678908.
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    188. Superbeads: immobilization in "sweet" chemistry. Chemistry. 2003 Jan 20; 9(2):372-7. Nahalka J, Liu Z, Chen X, Wang PG. PMID: 12532285.
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    190. Expeditious syntheses of two carbohydrate-linked cisplatin analogs. Carbohydr Res. 2002 Jun 05; 337(11):1043-6. Chen Y, Janczuk A, Chen X, Wang J, Ksebati M, Wang PG. PMID: 12039546.
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    191. Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads. Chembiochem. 2002 Apr 02; 3(4):348-55. Liu Z, Zhang J, Chen X, Wang PG. PMID: 11933236.
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    195. Fluorophore-labeled S-nitrosothiols. J Org Chem. 2001 Sep 07; 66(18):6064-73. Chen X, Wen Z, Xian M, Wang K, Ramachandran N, Tang X, Schlegel HB, Mutus B, Wang PG. PMID: 11529732.
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    196. Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides. J Am Chem Soc. 2001 Mar 07; 123(9):2081-2. Chen X, Fang J, Zhang J, Liu Z, Shao J, Kowal P, Andreana P, Wang PG. PMID: 11456841.
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    199. Changing the donor cofactor of bovine alpha 1, 3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of alpha-Gal epitopes. J Biol Chem. 2000 Oct 13; 275(41):31594-600. Chen X, Liu Z, Wang J, Fang J, Fan H, Wang PG. PMID: 10913140.
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    200. Production of alpha-galactosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and alpha-1,3-galactosyltransferase. Biotechnol Prog. 2000 Jul-Aug; 16(4):595-9. Chen X, Zhang W, Wang J, Fang J, Wang PG. PMID: 10933834.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    201. Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin. Biochem Biophys Res Commun. 2000 Feb 16; 268(2):310-4. Xian M, Wang K, Chen X, Hou Y, McGill A, Zhou B, Zhang ZY, Cheng JP, Wang PG. PMID: 10679200.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    202. Carbohydrates in transplantation. Curr Opin Chem Biol. 1999 Dec; 3(6):650-8. Chen X, Andreana PR, Wang PG. PMID: 10600719.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    203. Cloning, expression and characterization of a UDP-galactose 4-epimerase from Escherichia coli. Biotechnology Letters. 1999 Dec 1; 21(12):1131-1135. Chen CX, Kowal KP, Hamad HS, Fan FH, Wang WP. .
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    204. Enhanced Inhibition of Human Anti-Gal Antibody Binding to Mammalian Cells by Synthetic a-Gal Epitope Polymers. Journal of the American Chemical Society. 1999 Sep 1; 121(36):8174-8181. Wang WJ, Chen CX, Zhang ZW, Zacharek ZS, Chen CY, Wang WP. .
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    205. Bacteria targeted by human natural antibodies using alpha-Gal conjugated receptor-specific glycopolymers. Bioorg Med Chem. 1999 Aug; 7(8):1549-58. Li J, Zacharek S, Chen X, Wang J, Zhang W, Janczuk A, Wang PG. PMID: 10482447.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    206. A Unique Chemoenzymatic Synthesis of a-Galactosyl Epitope Derivatives Containing Free Amino Groups:  Efficient Separation and Further Manipulation. The Journal of Organic Chemistry. 1999 May 1; 64(11):4089-4094. Fang FJ, Chen CX, Zhang ZW, Wang WJ, Andreana AP, Wang WP. .
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    207. Alpha-Gal oligosaccharides: chemistry and potential biomedical application. Curr Med Chem. 1999 Feb; 6(2):155-64. Janczuk A, Li J, Zhang W, Chen X, Chen Y, Fang J, Wang J, Wang PG. PMID: 10189229.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    208. Highly Efficient Chemoenzymatic Synthesis of a-Galactosyl Epitopes with a Recombinant a(1?3)-Galactosyltransferase. Journal of the American Chemical Society. 1998 Jul 1; 120(27):6635-6638. Fang FJ, Li LJ, Chen CX, Zhang ZY, Wang WJ, Guo GZ, Zhang ZW, Yu YL, Brew BK, Wang WP. .
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