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Michael Toney

TitlePROF-AY
InstitutionUniversity of California Davis
DepartmentChemistry
Address2469 Chemistry Bldg
CA 95616
Phone530-754-5282
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Peng Z, Peralta MDR, Toney M. Extraordinarily Stable Amyloid Fibrils Engineered from Structurally Defined ß-Solenoid Proteins. Biochemistry. 2017 11 14; 56(45):6041-6050. PMID: 29064686.
      View in: PubMed
    2. Chung DH, Potter SC, Tanomrat AC, Ravikumar KM, Toney M. Site-directed mutant libraries for isolating minimal mutations yielding functional changes. Protein Eng Des Sel. 2017 05 01; 30(5):347-357. PMID: 28338893.
      View in: PubMed
    3. Slavney AH, Leppert L, Bartesaghi D, Gold-Parker A, Toney M, Savenije TJ, Neaton JB, Karunadasa HI. Defect-Induced Band-Edge Reconstruction of a Bismuth-Halide Double Perovskite for Visible-Light Absorption. J Am Chem Soc. 2017 Apr 04. PMID: 28353345.
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    4. Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415. PMID: 27689936.
      View in: PubMed
    5. Desai SH, Koryakina I, Case AE, Toney M, Atsumi S. Biological conversion of gaseous alkenes to liquid chemicals. Metab Eng. 2016 11; 38:98-104. PMID: 27424209.
      View in: PubMed
    6. Culbertson JE, Chung Dh, Ziebart KT, Espiritu E, Toney M. Conversion of aminodeoxychorismate synthase into anthranilate synthase with Janus mutations: mechanism of pyruvate elimination catalyzed by chorismate enzymes. Biochemistry. 2015 Apr 14; 54(14):2372-84. PMID: 25710100.
      View in: PubMed
    7. Peralta MD, Karsai A, Ngo A, Sierra C, Fong KT, Hayre NR, Mirzaee N, Ravikumar KM, Kluber AJ, Chen X, Liu GY, Toney M, Singh RR, Cox DL. Engineering amyloid fibrils from ß-solenoid proteins for biomaterials applications. ACS Nano. 2015 Jan 27; 9(1):449-63. PMID: 25562726.
      View in: PubMed
    8. Taylor JL, Price JE, Toney M. Directed evolution of the substrate specificity of dialkylglycine decarboxylase. Biochim Biophys Acta. 2015 Feb; 1854(2):146-55. PMID: 25500286; PMCID: PMC4334570.
    9. Fleischman NM, Das D, Kumar A, Xu Q, Chiu HJ, Jaroszewski L, Knuth MW, Klock HE, Miller MD, Elsliger MA, Godzik A, Lesley SA, Deacon AM, Wilson IA, Toney M. Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome. Protein Sci. 2014 Aug; 23(8):1060-76. PMID: 24888348; PMCID: PMC4116655.
    10. Chan-Huot M, Dos A, Zander R, Sharif S, Tolstoy PM, Compton S, Fogle E, Toney M, Shenderovich I, Denisov GS, Limbach HH. NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5'-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine. J Am Chem Soc. 2013 Dec 04; 135(48):18160-75. PMID: 24147985.
      View in: PubMed
    11. Toney M. Aspartate aminotransferase: an old dog teaches new tricks. Arch Biochem Biophys. 2014 Feb 15; 544:119-27. PMID: 24121043; PMCID: PMC3946379.
    12. Toney M. Common enzymological experiments allow free energy profile determination. Biochemistry. 2013 Aug 27; 52(34):5952-65. PMID: 23906433; PMCID: PMC4286415.
    13. Chan-Huot M, Lesot P, Pelupessy P, Duma L, Bodenhausen G, Duchambon P, Toney M, Reddy UV, Suryaprakash N. "On-the-fly" kinetics of enzymatic racemization using deuterium NMR in DNA-based chiral oriented media. Anal Chem. 2013 May 07; 85(9):4694-7. PMID: 23547756.
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    14. Addington TA, Mertz RW, Siegel JB, Thompson JM, Fisher AJ, Filkov V, Fleischman NM, Suen AA, Zhang C, Toney M. Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J Mol Biol. 2013 Apr 26; 425(8):1378-89. PMID: 23396064; PMCID: PMC3615137.
    15. Toney M, Castro JN, Addington TA. Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase. J Am Chem Soc. 2013 Feb 20; 135(7):2509-11. PMID: 23373756; PMCID: PMC3579662.
    16. Culbertson JE, Toney M. Expression and characterization of PhzE from P. aeruginosa PAO1: aminodeoxyisochorismate synthase involved in pyocyanin and phenazine-1-carboxylate production. Biochim Biophys Acta. 2013 Jan; 1834(1):240-6. PMID: 23099261.
      View in: PubMed
    17. Griswold WR, Castro JN, Fisher AJ, Toney M. Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase. J Am Chem Soc. 2012 May 23; 134(20):8436-8. PMID: 22551424; PMCID: PMC3425665.
    18. Griswold WR, Toney M. Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate. J Am Chem Soc. 2011 Sep 21; 133(37):14823-30. PMID: 21827189.
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    19. Limbach HH, Chan-Huot M, Sharif S, Tolstoy PM, Shenderovich IG, Denisov GS, Toney M. Critical hydrogen bonds and protonation states of pyridoxal 5'-phosphate revealed by NMR. Biochim Biophys Acta. 2011 Nov; 1814(11):1426-37. PMID: 21703367.
      View in: PubMed
    20. Griswold WR, Fisher AJ, Toney M. Crystal structures of aspartate aminotransferase reconstituted with 1-deazapyridoxal 5'-phosphate: internal aldimine and stable L-aspartate external aldimine. Biochemistry. 2011 Jul 05; 50(26):5918-24. PMID: 21627105.
      View in: PubMed
    21. Toney M. Controlling reaction specificity in pyridoxal phosphate enzymes. Biochim Biophys Acta. 2011 Nov; 1814(11):1407-18. PMID: 21664990; PMCID: PMC3359020.
    22. Fogle EJ, Toney M. Analysis of catalytic determinants of diaminopimelate and ornithine decarboxylases using alternate substrates. Biochim Biophys Acta. 2011 Sep; 1814(9):1113-9. PMID: 21640851; PMCID: PMC3124589.
    23. Chan-Huot M, Sharif S, Tolstoy PM, Toney M, Limbach HH. NMR studies of the stability, protonation States, and tautomerism of (13)C- AND (15)N-labeled aldimines of the coenzyme pyridoxal 5'-phosphate in water. Biochemistry. 2010 Dec 28; 49(51):10818-30. PMID: 21067170.
      View in: PubMed
    24. Hill MP, Carroll EC, Vang MC, Addington TA, Toney M, Larsen DS. Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase. J Am Chem Soc. 2010 Dec 01; 132(47):16953-61. PMID: 21058708; PMCID: PMC3021986.
    25. Mascal M, Hafezi N, Toney M. 1,4,7-Trimethyloxatriquinane: S(N)2 reaction at tertiary carbon. J Am Chem Soc. 2010 Aug 11; 132(31):10662-4. PMID: 20681692.
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    26. Butler JD, Coffman KC, Ziebart KT, Toney M, Kurth MJ. Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry. 2010 Aug 09; 16(30):9002-5. PMID: 20623732.
      View in: PubMed
    27. Fogle EJ, Toney M. Mutational analysis of substrate interactions with the active site of dialkylglycine decarboxylase. Biochemistry. 2010 Aug 03; 49(30):6485-93. PMID: 20540501; PMCID: PMC2994807.
    28. Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth MJ, Toney M. Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem. 2010 May 13; 53(9):3718-29. PMID: 20359225.
      View in: PubMed
    29. Ziebart KT, Toney M. Nucleophile specificity in anthranilate synthase, aminodeoxychorismate synthase, isochorismate synthase, and salicylate synthase. Biochemistry. 2010 Apr 06; 49(13):2851-9. PMID: 20170126.
      View in: PubMed
    30. Neiner D, Okamoto NL, Yu P, Leonard S, Condron CL, Toney M, Ramasse QM, Browning ND, Kauzlarich SM. Synthesis and characterization of K(8-x)(H2)ySi46. Inorg Chem. 2010 Feb 01; 49(3):815-22. PMID: 20039690.
      View in: PubMed
    31. Griswold WR, Toney M. Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1352-4. PMID: 20097067; PMCID: PMC3357107.
    32. Hill MP, Carroll EC, Toney M, Larsen DS. Rapid photodynamics of vitamin B6 coenzyme pyridoxal 5'-phosphate and its Schiff bases in solution. J Phys Chem B. 2008 May 08; 112(18):5867-73. PMID: 18416573.
      View in: PubMed
    33. Scott D, Toney M, Muzikár M. Harnessing the mechanism of glutathione reductase for synthesis of active site bound metallic nanoparticles and electrical connection to electrodes. J Am Chem Soc. 2008 Jan 23; 130(3):865-74. PMID: 18166048.
      View in: PubMed
    34. Spies MA, Toney M. Intrinsic primary and secondary hydrogen kinetic isotope effects for alanine racemase from global analysis of progress curves. J Am Chem Soc. 2007 Sep 05; 129(35):10678-85. PMID: 17691728.
      View in: PubMed
    35. Sharif S, Denisov GS, Toney M, Limbach HH. NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5'-phosphate model systems in polar solution. J Am Chem Soc. 2007 May 16; 129(19):6313-27. PMID: 17455937.
      View in: PubMed
    36. Sharif S, Schagen D, Toney M, Limbach HH. Coupling of functional hydrogen bonds in pyridoxal-5'-phosphate-enzyme model systems observed by solid-state NMR spectroscopy. J Am Chem Soc. 2007 Apr 11; 129(14):4440-55. PMID: 17371021.
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    37. Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney M, Kurth MJ. Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem. 2006 Dec 14; 49(25):7413-26. PMID: 17149871.
      View in: PubMed
    38. Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney M. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97. PMID: 16610782.
      View in: PubMed
    39. Sharif S, Denisov GS, Toney M, Limbach HH. NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: toward a distinction of geometric and equilibrium H-bond isotope effects. J Am Chem Soc. 2006 Mar 15; 128(10):3375-87. PMID: 16522119.
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    40. Fogle EJ, Liu W, Woon ST, Keller JW, Toney M. Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase. Biochemistry. 2005 Dec 20; 44(50):16392-404. PMID: 16342932.
      View in: PubMed
    41. Liu W, Peterson PE, Langston JA, Jin X, Zhou X, Fisher AJ, Toney M. Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2005 Mar 01; 44(8):2982-92. PMID: 15723541.
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    42. Toney M. Reaction specificity in pyridoxal phosphate enzymes. Arch Biochem Biophys. 2005 Jan 01; 433(1):279-87. PMID: 15581583.
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    43. Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney M. Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2004 Aug 31; 43(34):10896-905. PMID: 15323550.
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    44. Tu SL, Gunn A, Toney M, Britt RD, Lagarias JC. Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J Am Chem Soc. 2004 Jul 21; 126(28):8682-93. PMID: 15250720.
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    45. Spies MA, Woodward JJ, Watnik MR, Toney M. Alanine racemase free energy profiles from global analyses of progress curves. J Am Chem Soc. 2004 Jun 23; 126(24):7464-75. PMID: 15198593.
      View in: PubMed
    46. Liu W, Toney M. Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase. Biochemistry. 2004 May 04; 43(17):4998-5010. PMID: 15109259.
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    47. He Z, Stigers Lavoie KD, Bartlett PA, Toney M. Conservation of mechanism in three chorismate-utilizing enzymes. J Am Chem Soc. 2004 Mar 03; 126(8):2378-85. PMID: 14982443.
      View in: PubMed
    48. Christenson SD, Wu W, Spies MA, Shen B, Toney M. Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Biochemistry. 2003 Nov 04; 42(43):12708-18. PMID: 14580219.
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    49. Zhou X, Medhekar R, Toney M. A continuous-flow system for high-precision kinetics using small volumes. Anal Chem. 2003 Aug 01; 75(15):3681-7. PMID: 14572030.
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    50. Christenson SD, Liu W, Toney M, Shen B. A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2003 May 21; 125(20):6062-3. PMID: 12785829.
      View in: PubMed
    51. Spies MA, Toney M. Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase. Biochemistry. 2003 May 06; 42(17):5099-107. PMID: 12718553.
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    52. Liu W, Rogers CJ, Fisher AJ, Toney M. Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition. Biochemistry. 2002 Oct 15; 41(41):12320-8. PMID: 12369820.
      View in: PubMed
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