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A Novel Glutathione S-Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS Vibrio parahaemolyticus Shrimp Pathogen. Toxins (Basel). 2021 09 17; 13(9).
Valenzuela-Chavira I, Corona-Martinez DO, Garcia-Orozco KD, Beltran-Torres M, Sanchez-Lopez F, Arvizu-Flores AA, Sugich-Miranda R, Lopez-Zavala AA, Robles-Zepeda RE, Islas-Osuna MA, Ochoa-Leyva A, Toney MD, Serrano-Posada H, Sotelo-Mundo RR. PMID: 34564668; PMCID: PMC8472993.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins. PLoS One. 2020; 15(2):e0229319.
Peng Z, Peralta MDR, Cox DL, Toney MD. PMID: 32084222; PMCID: PMC7034853.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells. Nucleic Acids Res. 2019 11 18; 47(20):10801-10814.
Wang Y, Chung DH, Monteleone LR, Li J, Chiang Y, Toney MD, Beal PA. PMID: 31552420; PMCID: PMC6846710.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Carbon Acidity in Enzyme Active Sites. Front Bioeng Biotechnol. 2019; 7:25.
Toney MD. PMID: 30838206; PMCID: PMC6389717.
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PubMed Mentions:
5
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In silico stress-strain measurements on self-assembled protein lattices. Soft Matter. 2018 Oct 17; 14(40):8095-8104.
Baarda RA, Marianchuk TL, Toney MD, Cox DL. PMID: 30159554.
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PubMed Mentions: Fields:
Translation:
Cells
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High Tensile Strength of Engineered β-Solenoid Fibrils via Sonication and Pulling. Biophys J. 2017 Nov 07; 113(9):1945-1955.
Peng Z, Parker AS, Peralta MDR, Ravikumar KM, Cox DL, Toney MD. PMID: 29117519; PMCID: PMC5685653.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Extraordinarily Stable Amyloid Fibrils Engineered from Structurally Defined β-Solenoid Proteins. Biochemistry. 2017 11 14; 56(45):6041-6050.
Peng Z, Peralta MDR, Toney MD. PMID: 29064686.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Site-directed mutant libraries for isolating minimal mutations yielding functional changes. Protein Eng Des Sel. 2017 05 01; 30(5):347-357.
Chung DH, Potter SC, Tanomrat AC, Ravikumar KM, Toney MD. PMID: 28338893.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415.
Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. PMID: 27689936.
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PubMed Mentions:
2 Fields:
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Biological conversion of gaseous alkenes to liquid chemicals. Metab Eng. 2016 11; 38:98-104.
Desai SH, Koryakina I, Case AE, Toney MD, Atsumi S. PMID: 27424209.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Conversion of aminodeoxychorismate synthase into anthranilate synthase with Janus mutations: mechanism of pyruvate elimination catalyzed by chorismate enzymes. Biochemistry. 2015 Apr 14; 54(14):2372-84.
Culbertson JE, Chung Dh, Ziebart KT, Espiritu E, Toney MD. PMID: 25710100.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Engineering amyloid fibrils from β-solenoid proteins for biomaterials applications. ACS Nano. 2015 Jan 27; 9(1):449-63.
Peralta MD, Karsai A, Ngo A, Sierra C, Fong KT, Hayre NR, Mirzaee N, Ravikumar KM, Kluber AJ, Chen X, Liu GY, Toney MD, Singh RR, Cox DL. PMID: 25562726.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Directed evolution of the substrate specificity of dialkylglycine decarboxylase. Biochim Biophys Acta. 2015 Feb; 1854(2):146-55.
Taylor JL, Price JE, Toney MD. PMID: 25500286; PMCID: PMC4334570.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Nitrate reductase (15)N discrimination in Arabidopsis thaliana, Zea mays, Aspergillus niger, Pichea angusta, and Escherichia coli. Front Plant Sci. 2014; 5:317.
Carlisle E, Yarnes C, Toney MD, Bloom AJ. PMID: 25071800; PMCID: PMC4078254.
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PubMed Mentions:
6
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Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome. Protein Sci. 2014 Aug; 23(8):1060-76.
Fleischman NM, Das D, Kumar A, Xu Q, Chiu HJ, Jaroszewski L, Knuth MW, Klock HE, Miller MD, Elsliger MA, Godzik A, Lesley SA, Deacon AM, Wilson IA, Toney MD. PMID: 24888348; PMCID: PMC4116655.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5'-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine. J Am Chem Soc. 2013 Dec 04; 135(48):18160-75.
Chan-Huot M, Dos A, Zander R, Sharif S, Tolstoy PM, Compton S, Fogle E, Toney MD, Shenderovich I, Denisov GS, Limbach HH. PMID: 24147985.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Aspartate aminotransferase: an old dog teaches new tricks. Arch Biochem Biophys. 2014 Feb 15; 544:119-27.
Toney MD. PMID: 24121043; PMCID: PMC3946379.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Common enzymological experiments allow free energy profile determination. Biochemistry. 2013 Aug 27; 52(34):5952-65.
Toney MD. PMID: 23906433; PMCID: PMC4286415.
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PubMed Mentions:
6 Fields:
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"On-the-fly" kinetics of enzymatic racemization using deuterium NMR in DNA-based chiral oriented media. Anal Chem. 2013 May 07; 85(9):4694-7.
Chan-Huot M, Lesot P, Pelupessy P, Duma L, Bodenhausen G, Duchambon P, Toney MD, Reddy UV, Suryaprakash N. PMID: 23547756.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Janus: prediction and ranking of mutations required for functional interconversion of enzymes. J Mol Biol. 2013 Apr 26; 425(8):1378-89.
Addington TA, Mertz RW, Siegel JB, Thompson JM, Fisher AJ, Filkov V, Fleischman NM, Suen AA, Zhang C, Toney MD. PMID: 23396064; PMCID: PMC3615137.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase. J Am Chem Soc. 2013 Feb 20; 135(7):2509-11.
Toney MD, Castro JN, Addington TA. PMID: 23373756; PMCID: PMC3579662.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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Expression and characterization of PhzE from P. aeruginosa PAO1: aminodeoxyisochorismate synthase involved in pyocyanin and phenazine-1-carboxylate production. Biochim Biophys Acta. 2013 Jan; 1834(1):240-6.
Culbertson JE, Toney MD. PMID: 23099261.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase. J Am Chem Soc. 2012 May 23; 134(20):8436-8.
Griswold WR, Castro JN, Fisher AJ, Toney MD. PMID: 22551424; PMCID: PMC3425665.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Temperature-induced transitions in the structure and interfacial rheology of human meibum. Biophys J. 2012 Jan 18; 102(2):369-76.
Leiske D, Leiske DL, Leiske C, Leiske CI, Leiske D, Leiske DR, Toney M, Toney MF, Senchyna M, Ketelson H, Ketelson HA, Meadows D, Meadows DL, Fuller GG. PMID: 22339874; PMCID: PMC3260664.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate. J Am Chem Soc. 2011 Sep 21; 133(37):14823-30.
Griswold WR, Toney MD. PMID: 21827189.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Pyridoxal phosphate enzymology. Biochim Biophys Acta. 2011 Nov; 1814(11):1405-6.
Toney MD. PMID: 21871586.
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PubMed Mentions:
4 Fields:
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Critical hydrogen bonds and protonation states of pyridoxal 5'-phosphate revealed by NMR. Biochim Biophys Acta. 2011 Nov; 1814(11):1426-37.
Limbach HH, Chan-Huot M, Sharif S, Tolstoy PM, Shenderovich IG, Denisov GS, Toney MD. PMID: 21703367.
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PubMed Mentions:
19 Fields:
Translation:
Cells
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Crystal structures of aspartate aminotransferase reconstituted with 1-deazapyridoxal 5'-phosphate: internal aldimine and stable L-aspartate external aldimine. Biochemistry. 2011 Jul 05; 50(26):5918-24.
Griswold WR, Fisher AJ, Toney MD. PMID: 21627105.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Controlling reaction specificity in pyridoxal phosphate enzymes. Biochim Biophys Acta. 2011 Nov; 1814(11):1407-18.
Toney MD. PMID: 21664990; PMCID: PMC3359020.
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PubMed Mentions:
53 Fields:
Translation:
Cells
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Analysis of catalytic determinants of diaminopimelate and ornithine decarboxylases using alternate substrates. Biochim Biophys Acta. 2011 Sep; 1814(9):1113-9.
Fogle EJ, Toney MD. PMID: 21640851; PMCID: PMC3124589.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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NMR studies of the stability, protonation States, and tautomerism of (13)C- AND (15)N-labeled aldimines of the coenzyme pyridoxal 5'-phosphate in water. Biochemistry. 2010 Dec 28; 49(51):10818-30.
Chan-Huot M, Sharif S, Tolstoy PM, Toney MD, Limbach HH. PMID: 21067170.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Light-enhanced catalysis by pyridoxal phosphate-dependent aspartate aminotransferase. J Am Chem Soc. 2010 Dec 01; 132(47):16953-61.
Hill MP, Carroll EC, Vang MC, Addington TA, Toney MD, Larsen DS. PMID: 21058708; PMCID: PMC3021986.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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1,4,7-Trimethyloxatriquinane: S(N)2 reaction at tertiary carbon. J Am Chem Soc. 2010 Aug 11; 132(31):10662-4.
Mascal M, Hafezi N, Toney MD. PMID: 20681692.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry. 2010 Aug 09; 16(30):9002-5.
Butler JD, Coffman KC, Ziebart KT, Toney MD, Kurth MJ. PMID: 20623732.
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PubMed Mentions:
4 Fields:
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Mutational analysis of substrate interactions with the active site of dialkylglycine decarboxylase. Biochemistry. 2010 Aug 03; 49(30):6485-93.
Fogle EJ, Toney MD. PMID: 20540501; PMCID: PMC2994807.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem. 2010 May 13; 53(9):3718-29.
Ziebart KT, Dixon SM, Avila B, El-Badri MH, Guggenheim KG, Kurth MJ, Toney MD. PMID: 20359225.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Nucleophile specificity in anthranilate synthase, aminodeoxychorismate synthase, isochorismate synthase, and salicylate synthase. Biochemistry. 2010 Apr 06; 49(13):2851-9.
Ziebart KT, Toney MD. PMID: 20170126.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1352-4.
Griswold WR, Toney MD. PMID: 20097067; PMCID: PMC3357107.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Rapid photodynamics of vitamin B6 coenzyme pyridoxal 5'-phosphate and its Schiff bases in solution. J Phys Chem B. 2008 May 08; 112(18):5867-73.
Hill MP, Carroll EC, Toney MD, Larsen DS. PMID: 18416573.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Harnessing the mechanism of glutathione reductase for synthesis of active site bound metallic nanoparticles and electrical connection to electrodes. J Am Chem Soc. 2008 Jan 23; 130(3):865-74.
Scott D, Toney M, Muzikár M. PMID: 18166048.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Intrinsic primary and secondary hydrogen kinetic isotope effects for alanine racemase from global analysis of progress curves. J Am Chem Soc. 2007 Sep 05; 129(35):10678-85.
Spies MA, Toney MD. PMID: 17691728.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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NMR localization of protons in critical enzyme hydrogen bonds. J Am Chem Soc. 2007 Aug 08; 129(31):9558-9.
Sharif S, Fogle E, Toney MD, Denisov GS, Shenderovich IG, Buntkowsky G, Tolstoy PM, Huot MC, Limbach HH. PMID: 17628065.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5'-phosphate model systems in polar solution. J Am Chem Soc. 2007 May 16; 129(19):6313-27.
Sharif S, Denisov GS, Toney MD, Limbach HH. PMID: 17455937.
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PubMed Mentions:
25 Fields:
Translation:
Cells
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15N nuclear magnetic resonance studies of acid-base properties of pyridoxal-5'-phosphate aldimines in aqueous solution. J Phys Chem B. 2007 Apr 19; 111(15):3869-76.
Sharif S, Huot MC, Tolstoy PM, Toney MD, Jonsson KH, Limbach HH. PMID: 17388551.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Coupling of functional hydrogen bonds in pyridoxal-5'-phosphate-enzyme model systems observed by solid-state NMR spectroscopy. J Am Chem Soc. 2007 Apr 11; 129(14):4440-55.
Sharif S, Schagen D, Toney MD, Limbach HH. PMID: 17371021.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem. 2006 Dec 14; 49(25):7413-26.
Dixon S, Ziebart KT, He Z, Jeddeloh M, Yoo CL, Wang X, Lehman A, Lam KS, Toney MD, Kurth MJ. PMID: 17149871.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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X-ray crystallographic structures of enamine and amine Schiff bases of pyridoxal and its 1:1 hydrogen-bonded complexes with benzoic acid derivatives: evidence for coupled inter- and intramolecular proton transfer. Acta Crystallogr B. 2006 Jun; 62(Pt 3):480-7.
Sharif S, Powell DR, Schagen D, Steiner T, Toney MD, Fogle E, Limbach HH. PMID: 16710068.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97.
Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD. PMID: 16610782.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Direct detection and kinetic analysis of covalent intermediate formation in the 4-amino-4-deoxychorismate synthase catalyzed reaction. Biochemistry. 2006 Apr 18; 45(15):5019-28.
He Z, Toney MD. PMID: 16605270.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: toward a distinction of geometric and equilibrium H-bond isotope effects. J Am Chem Soc. 2006 Mar 15; 128(10):3375-87.
Sharif S, Denisov GS, Toney MD, Limbach HH. PMID: 16522119.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase. Biochemistry. 2005 Dec 20; 44(50):16392-404.
Fogle EJ, Liu W, Woon ST, Keller JW, Toney MD. PMID: 16342932.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy. Biochim Biophys Acta. 2006 Feb; 1764(2):230-8.
Schnackerz KD, Keller J, Phillips RS, Toney MD. PMID: 16290167.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2005 Mar 01; 44(8):2982-92.
Liu W, Peterson PE, Langston JA, Jin X, Zhou X, Fisher AJ, Toney MD. PMID: 15723541.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Reaction specificity in pyridoxal phosphate enzymes. Arch Biochem Biophys. 2005 Jan 01; 433(1):279-87.
Toney MD. PMID: 15581583.
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PubMed Mentions:
79 Fields:
Translation:
Cells
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Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity. J Biol Chem. 2005 Jan 21; 280(3):1754-63.
Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, Shleper M, Li P, Toney MD, Kartvelishvily E, Wolosker H. PMID: 15536068.
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PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2004 Aug 31; 43(34):10896-905.
Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney MD. PMID: 15323550.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Biliverdin reduction by cyanobacterial phycocyanobilin:ferredoxin oxidoreductase (PcyA) proceeds via linear tetrapyrrole radical intermediates. J Am Chem Soc. 2004 Jul 21; 126(28):8682-93.
Tu SL, Gunn A, Toney MD, Britt RD, Lagarias JC. PMID: 15250720.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Alanine racemase free energy profiles from global analyses of progress curves. J Am Chem Soc. 2004 Jun 23; 126(24):7464-75.
Spies MA, Woodward JJ, Watnik MR, Toney MD. PMID: 15198593.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase. Biochemistry. 2004 May 04; 43(17):4998-5010.
Liu W, Toney MD. PMID: 15109259.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Conservation of mechanism in three chorismate-utilizing enzymes. J Am Chem Soc. 2004 Mar 03; 126(8):2378-85.
He Z, Stigers Lavoie KD, Bartlett PA, Toney MD. PMID: 14982443.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Biochemistry. 2003 Nov 04; 42(43):12708-18.
Christenson SD, Wu W, Spies MA, Shen B, Toney MD. PMID: 14580219.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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A continuous-flow system for high-precision kinetics using small volumes. Anal Chem. 2003 Aug 01; 75(15):3681-7.
Zhou X, Medhekar R, Toney MD. PMID: 14572030.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc. 2003 May 21; 125(20):6062-3.
Christenson SD, Liu W, Toney MD, Shen B. PMID: 12785829.
View in:
PubMed Mentions:
31 Fields:
Translation:
Cells
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Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase. Biochemistry. 2003 May 06; 42(17):5099-107.
Spies MA, Toney MD. PMID: 12718553.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
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Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition. Biochemistry. 2002 Oct 15; 41(41):12320-8.
Liu W, Rogers CJ, Fisher AJ, Toney MD. PMID: 12369820.
View in:
PubMed Mentions:
17 Fields:
Translation:
Cells