Peter A Beal

Title(s)Professor, Chemistry
SchoolUniversity of California, Davis
Address5469 Chemistry Bldg
CA 95616
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    UC Davis Training Program in Chemical Biology
    NIH/NIGMS T32GM113770Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Nucleobase analog for the next generation siRNa
    NIH/NIGMS R01GM080784Apr 1, 2007 - Aug 31, 2021
    Role: Principal Investigator
    RNA-specific ligands: An Approach to New Antivirals
    NIH/NIAID R21AI049062Jan 1, 2001 - Aug 31, 2005
    Role: Principal Investigator
    NIH/NIAID R01AI049062Jan 1, 2001 - Dec 31, 2004
    Role: Principal Investigator
    The Bioorganic Chemistry of RNA editing by ADARs
    NIH/NIGMS R01GM061115Apr 1, 2000 - Jul 31, 2019
    Role: Principal Investigator
    RNA-regulation and signal transduction by PKR
    NIH/NIGMS R01GM057214May 1, 1998 - Apr 30, 2008
    Role: Co-Principal Investigator
    NIH/NCI F32CA062585Sep 30, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 2021 May 12; 143(18):6865-6876. Doherty EE, Wilcox XE, van Sint Fiet L, Kemmel C, Turunen JJ, Klein B, Tantillo DJ, Fisher AJ, Beal PA. PMID: 33939417.
      View in: PubMed   Mentions:    Fields:    
    2. Ester modification at the 3' end of anti-microRNA oligonucleotides increases potency of microRNA inhibition. Bioorg Med Chem. 2021 01 01; 29:115894. Pham KM, Suter SR, Lu SS, Beal PA. PMID: 33290908.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res. 2020 08 20; 48(14):7958-7972. Thuy-Boun AS, Thomas JM, Grajo HL, Palumbo CM, Park S, Nguyen LT, Fisher AJ, Beal PA. PMID: 32597966.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Versatile 3' Functionalization of CRISPR Single Guide RNA. Chembiochem. 2020 06 02; 21(11):1633-1640. Palumbo CM, Gutierrez-Bujari JM, O'Geen H, Segal DJ, Beal PA. PMID: 31943634.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells. Nucleic Acids Res. 2019 11 18; 47(20):10801-10814. Wang Y, Chung DH, Monteleone LR, Li J, Chiang Y, Toney MD, Beal PA. PMID: 31552420.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Off-Target Editing by CRISPR-Guided DNA Base Editors. Biochemistry. 2019 09 10; 58(36):3727-3734. Park S, Beal PA. PMID: 31433621.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. A Bump-Hole Approach for Directed RNA Editing. Cell Chem Biol. 2019 02 21; 26(2):269-277.e5. Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. PMID: 30581135.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Nucleoside analogs in the study of the epitranscriptome. Methods. 2019 03 01; 156:46-52. Palumbo CM, Beal PA. PMID: 30827466.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Structural basis for eukaryotic mRNA modification. Curr Opin Struct Biol. 2018 12; 53:59-68. Fisher AJ, Beal PA. PMID: 29913347.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Selective Recognition of RNA Substrates by ADAR Deaminase Domains. Biochemistry. 2018 03 13; 57(10):1640-1651. Wang Y, Park S, Beal PA. PMID: 29457714.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    11. Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. Org Biomol Chem. 2017 Dec 06; 15(47):10029-10036. Suter SR, Ball-Jones A, Mumbleau MM, Valenzuela R, Ibarra-Soza J, Owens H, Fisher AJ, Beal PA. PMID: 29164215.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    12. TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length. Bioorg Med Chem. 2018 01 01; 26(1):77-83. Hu T, Suter SR, Mumbleau MM, Beal PA. PMID: 29174509.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. Nucleic Acids Res. 2017 04 07; 45(6):3369-3377. Zheng Y, Lorenzo C, Beal PA. PMID: 28132026.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    14. Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures. RNA Biol. 2017 02; 14(2):164-170. Fisher AJ, Beal PA. PMID: 27937139.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Guide Strand 3'-End Modifications Regulate siRNA Specificity. Chembiochem. 2016 Dec 14; 17(24):2340-2345. Valenzuela RA, Onizuka K, Ball-Jones AA, Hu T, Suter SR, Beal PA. PMID: 27731539.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. Nucleic Acids Res. 2016 Nov 16; 44(20):9872-9880. Wang Y, Beal PA. PMID: 27614075.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Structure-Guided Control of siRNA Off-Target Effects. J Am Chem Soc. 2016 07 20; 138(28):8667-9. Suter SR, Sheu-Gruttadauria J, Schirle NT, Valenzuela R, Ball-Jones AA, Onizuka K, MacRae IJ, Beal PA. PMID: 27387838.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol. 2016 05; 23(5):426-33. Matthews MM, Thomas JM, Zheng Y, Tran K, Phelps KJ, Scott AI, Havel J, Fisher AJ, Beal PA. PMID: 27065196.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    19. Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1799-802. Zheng Y, Beal PA. PMID: 26927424.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1. ACS Chem Biol. 2015 Nov 20; 10(11):2512-9. Wang Y, Havel J, Beal PA. PMID: 26372505.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8713-6. Mizrahi RA, Shin D, Sinkeldam RW, Phelps KJ, Fin A, Tantillo DJ, Tor Y, Beal PA. PMID: 26095193.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61. Tran K, Arkin MR, Beal PA. PMID: 25749683.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res. 2015 Jan; 43(2):1123-32. Phelps KJ, Tran K, Eifler T, Erickson AI, Fisher AJ, Beal PA. PMID: 25564529.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    24. Base modification strategies to modulate immune stimulation by an siRNA. Chembiochem. 2015 Jan 19; 16(2):262-7. Valenzuela RA, Suter SR, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Beal PA. PMID: 25487859.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    25. Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem Biol. 2014 Aug 15; 9(8):1780-7. Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA. PMID: 24896732.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    26. Short interfering RNA guide strand modifiers from computational screening. J Am Chem Soc. 2013 Nov 13; 135(45):17069-77. Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA. PMID: 24152142.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae. Biochemistry. 2013 Nov 12; 52(45):7857-69. Eifler T, Pokharel S, Beal PA. PMID: 24124932.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    28. Computational approaches to predicting the impact of novel bases on RNA structure and stability. ACS Chem Biol. 2013 Nov 15; 8(11):2354-9. Harrison JG, Zheng YB, Beal PA, Tantillo DJ. PMID: 24063428.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    29. Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides. ACS Chem Biol. 2013 Apr 19; 8(4):832-9. Mizrahi RA, Schirle NT, Beal PA. PMID: 23394403.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding. J Am Chem Soc. 2012 Oct 24; 134(42):17643-52. Ghanty U, Fostvedt E, Valenzuela R, Beal PA, Burrows CJ. PMID: 23030736.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    31. Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases. Nucleic Acids Res. 2012 Oct; 40(19):9825-35. Mizrahi RA, Phelps KJ, Ching AY, Beal PA. PMID: 22885375.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    32. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. PMID: 22766576.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing. Chembiochem. 2012 Jun 18; 13(9):1338-48. Onizuka K, Yeo J, David SS, Beal PA. PMID: 22639086.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    34. ADAR proteins: structure and catalytic mechanism. Curr Top Microbiol Immunol. 2012; 353:1-33. Goodman RA, Macbeth MR, Beal PA. PMID: 21769729.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    35. Novel modifications in RNA. ACS Chem Biol. 2012 Jan 20; 7(1):100-9. Phelps K, Morris A, Beal PA. PMID: 22148740.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    36. Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem. 2011 Sep 16; 76(18):7295-300. Peacock H, Kannan A, Beal PA, Burrows CJ. PMID: 21834582.
      View in: PubMed   Mentions: 22     Fields:    
    37. Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc. 2011 Jun 22; 133(24):9200-3. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA. PMID: 21612237.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    38. Covalent stabilization of a small molecule-RNA complex. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5002-5. Peacock H, Bachu R, Beal PA. PMID: 21601451.
      View in: PubMed   Mentions: 5     Fields:    
    39. RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20715-9. Yeo J, Goodman RA, Schirle NT, David SS, Beal PA. PMID: 21068368.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    40. Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs. ACS Chem Biol. 2010 Dec 17; 5(12):1115-24. Peacock H, Fostvedt E, Beal PA. PMID: 20863128.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide. Org Biomol Chem. 2010 Nov 07; 8(21):4898-904. Schirle NT, Goodman RA, Krishnamurthy M, Beal PA. PMID: 20820662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    42. N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA. Org Lett. 2010 Mar 05; 12(5):1044-7. Peacock H, Maydanovych O, Beal PA. PMID: 20108910.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    43. Covalent hydration energies for purine analogs by quantum chemical methods. J Comput Chem. 2010 Mar; 31(4):721-5. Wang SC, Beal PA, Tantillo DJ. PMID: 19569207.
      View in: PubMed   Mentions: 3     Fields:    
    44. Synthesis and evaluation of an RNA editing substrate bearing 2'-deoxy-2'-mercaptoadenosine. Nucleosides Nucleotides Nucleic Acids. 2009 Feb; 28(2):78-88. Jayalath P, Pokharel S, Véliz E, Beal PA. PMID: 19219738.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    45. Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. Bioorg Med Chem. 2008 Oct 01; 16(19):8914-21. Krishnamurthy M, Schirle NT, Beal PA. PMID: 18789700.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    46. The chemistry and biology of RNA editing by adenosine deaminases. Nucleic Acids Symp Ser (Oxf). 2007; (51):83-4. Beal PA, Maydanovych O, Pokharel S. PMID: 18029597.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    47. Macrocyclic helix-threading peptides for targeting RNA. Angew Chem Int Ed Engl. 2007; 46(37):7044-7. Krishnamurthy M, Simon K, Orendt AM, Beal PA. PMID: 17691090.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    48. RNA binding and thiolytic stability of a quinoline-containing helix-threading peptide. Org Biomol Chem. 2006 Feb 21; 4(4):639-45. Krishnamurthy M, Gooch BD, Beal PA. PMID: 16467938.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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