Peter A Beal

Title(s)Professor, Chemistry
SchoolSchool of Veterinary Medicine
Address5469 Chemistry Bldg
CA 95616
Phone530-752-4132
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    UC Davis Training Program in Chemical Biology
    NIH/NIGMS T32GM113770Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Nucleobase analog for the next generation siRNa
    NIH/NIGMS R01GM080784Apr 1, 2007 - Aug 31, 2021
    Role: Principal Investigator
    RNA-specific ligands: An Approach to New Antivirals
    NIH/NIAID R21AI049062Jan 1, 2001 - Aug 31, 2005
    Role: Principal Investigator
    RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALS
    NIH/NIAID R01AI049062Jan 1, 2001 - Dec 31, 2004
    Role: Principal Investigator
    The Bioorganic Chemistry of RNA editing by ADARs
    NIH/NIGMS R01GM061115Apr 1, 2000 - Jul 31, 2019
    Role: Principal Investigator
    RNA-regulation and signal transduction by PKR
    NIH/NIGMS R01GM057214May 1, 1998 - Apr 30, 2008
    Role: Co-Principal Investigator
    RECEPTOR FOR A TUMOR-REVERSING NATURAL PRODUCT--TRAPOXIN
    NIH/NCI F32CA062585Sep 30, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Site-specific regulation of RNA editing with ribose-modified nucleoside analogs in ADAR guide strands. Nucleic Acids Res. 2024 Jun 03. Jauregui-Matos V, Jacobs O, Ouye R, Mozumder S, Salvador PJ, Fink KD, Beal PA. PMID: 38828787.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Non-Targeted Detection of Synthetic Oligonucleotides in Equine Serum Using Liquid Chromatography-High-Resolution Mass Spectrometry. Int J Mol Sci. 2024 May 25; 25(11). Helmes E, Montgomery J, Alarcio G, Mendoza HG, Blea JA, Beal PA, Moeller BC. PMID: 38891955; PMCID: PMC11172053.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine. Bioorg Med Chem. 2024 Mar 29; 104:117700. Wong BL, Mendoza HG, Jacobsen CS, Beal PA. PMID: 38583236.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Structural and functional effects of inosine modification in mRNA. RNA. 2024 Mar 26. Mendoza HG, Beal PA. PMID: 38531652.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1. Biochemistry. 2024 Feb 06; 63(3):282-293. Karki A, Campbell KB, Mozumder S, Fisher AJ, Beal PA. PMID: 38190734; PMCID: PMC10872254.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Chemical Modifications in RNA: Elucidating the Chemistry of dsRNA-Specific Adenosine Deaminases (ADARs). Acc Chem Res. 2023 09 19; 56(18):2489-2499. Mendoza HG, Beal PA. PMID: 37665999; PMCID: PMC10826463.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites. ACS Chem Biol. 2023 10 20; 18(10):2188-2199. Jacobsen CS, Salvador P, Yung JF, Kragness S, Mendoza HG, Mandel G, Beal PA. PMID: 37040436; PMCID: PMC10581013.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes. Biochemistry. 2023 04 18; 62(8):1376-1387. Mendoza HG, Matos VJ, Park S, Pham KM, Beal PA. PMID: 36972568; PMCID: PMC10804918.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Nucleoside analogs in ADAR guide strands targeting 5'-UA̲ sites. RSC Chem Biol. 2023 Jan 04; 4(1):74-83. Brinkman HF, Jauregui Matos V, Mendoza HG, Doherty EE, Beal PA. PMID: 36685257; PMCID: PMC9811522.
      View in: PubMed   Mentions: 2  
    10. ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site. Nucleic Acids Res. 2022 10 28; 50(19):10857-10868. Doherty EE, Karki A, Wilcox XE, Mendoza HG, Manjunath A, Matos VJ, Fisher AJ, Beal PA. PMID: 36243986; PMCID: PMC9638939.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. Oligonucleotide-directed RNA editing in primates. Mol Ther. 2022 06 01; 30(6):2117-2119. Doherty EE, Beal PA. PMID: 35460609; PMCID: PMC9171251.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 2021 05 12; 143(18):6865-6876. Doherty EE, Wilcox XE, van Sint Fiet L, Kemmel C, Turunen JJ, Klein B, Tantillo DJ, Fisher AJ, Beal PA. PMID: 33939417; PMCID: PMC8608393.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. Regulation of RNA editing by intracellular acidification. Nucleic Acids Res. 2021 04 19; 49(7):4020-4036. Malik TN, Doherty EE, Gaded VM, Hill TM, Beal PA, Emeson RB. PMID: 33721028; PMCID: PMC8053123.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Ester modification at the 3' end of anti-microRNA oligonucleotides increases potency of microRNA inhibition. Bioorg Med Chem. 2021 01 01; 29:115894. Pham KM, Suter SR, Lu SS, Beal PA. PMID: 33290908; PMCID: PMC8610567.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. High-throughput mutagenesis reveals unique structural features of human ADAR1. Nat Commun. 2020 10 12; 11(1):5130. Park S, Doherty EE, Xie Y, Padyana AK, Fang F, Zhang Y, Karki A, Lebrilla CB, Siegel JB, Beal PA. PMID: 33046702; PMCID: PMC7550611.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res. 2020 08 20; 48(14):7958-7972. Thuy-Boun AS, Thomas JM, Grajo HL, Palumbo CM, Park S, Nguyen LT, Fisher AJ, Beal PA. PMID: 32597966; PMCID: PMC7641318.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    17. DNA capture by a CRISPR-Cas9-guided adenine base editor. Science. 2020 07 31; 369(6503):566-571. Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. PMID: 32732424; PMCID: PMC8598131.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    18. Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide. Chemistry. 2020 Aug 06; 26(44):9874-9878. Knutson SD, Korn MM, Johnson RP, Monteleone LR, Dailey DM, Swenson CS, Beal PA, Heemstra JM. PMID: 32428320; PMCID: PMC7674219.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    19. Versatile 3' Functionalization of CRISPR Single Guide RNA. Chembiochem. 2020 Jun 02; 21(11):1633-1640. Palumbo CM, Gutierrez-Bujari JM, O'Geen H, Segal DJ, Beal PA. PMID: 31943634; PMCID: PMC7323579.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells. Nucleic Acids Res. 2019 11 18; 47(20):10801-10814. Wang Y, Chung DH, Monteleone LR, Li J, Chiang Y, Toney MD, Beal PA. PMID: 31552420; PMCID: PMC6846710.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. Off-Target Editing by CRISPR-Guided DNA Base Editors. Biochemistry. 2019 Sep 10; 58(36):3727-3734. Park S, Beal PA. PMID: 31433621; PMCID: PMC7309633.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    22. A Bump-Hole Approach for Directed RNA Editing. Cell Chem Biol. 2019 02 21; 26(2):269-277.e5. Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. PMID: 30581135; PMCID: PMC6386613.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. Nucleoside analogs in the study of the epitranscriptome. Methods. 2019 03 01; 156:46-52. Palumbo CM, Beal PA. PMID: 30827466; PMCID: PMC6400310.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Structural basis for eukaryotic mRNA modification. Curr Opin Struct Biol. 2018 12; 53:59-68. Fisher AJ, Beal PA. PMID: 29913347.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Differentiating Positional Isomers of Nucleoside Modifications by Higher-Energy Collisional Dissociation Mass Spectrometry (HCD MS). J Am Soc Mass Spectrom. 2018 08; 29(8):1745-1756. Jora M, Burns AP, Ross RL, Lobue PA, Zhao R, Palumbo CM, Beal PA, Addepalli B, Limbach PA. PMID: 29949056; PMCID: PMC6062210.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    26. Selective Recognition of RNA Substrates by ADAR Deaminase Domains. Biochemistry. 2018 03 13; 57(10):1640-1651. Wang Y, Park S, Beal PA. PMID: 29457714; PMCID: PMC5898644.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    27. Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. Org Biomol Chem. 2017 Dec 06; 15(47):10029-10036. Suter SR, Ball-Jones A, Mumbleau MM, Valenzuela R, Ibarra-Soza J, Owens H, Fisher AJ, Beal PA. PMID: 29164215; PMCID: PMC5734094.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    28. Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. Nat Methods. 2018 01; 15(1):53-56. Lai Z, Tsugawa H, Wohlgemuth G, Mehta S, Mueller M, Zheng Y, Ogiwara A, Meissen J, Showalter M, Takeuchi K, Kind T, Beal P, Arita M, Fiehn O. PMID: 29176591; PMCID: PMC6358022.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    29. TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length. Bioorg Med Chem. 2018 01 01; 26(1):77-83. Hu T, Suter SR, Mumbleau MM, Beal PA. PMID: 29174509; PMCID: PMC5733708.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Adenosine Deaminases That Act on RNA (ADARs). Enzymes. 2017; 41:215-268. Wang Y, Zheng Y, Beal PA. PMID: 28601223.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    31. DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. Nucleic Acids Res. 2017 04 07; 45(6):3369-3377. Zheng Y, Lorenzo C, Beal PA. PMID: 28132026; PMCID: PMC5389660.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    32. Synthesis of native-like crosslinked duplex RNA and study of its properties. Bioorg Med Chem. 2017 04 01; 25(7):2191-2199. Onizuka K, Hazemi ME, Thomas JM, Monteleone LR, Yamada K, Imoto S, Beal PA, Nagatsugi F. PMID: 28268052; PMCID: PMC5969911.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    33. How do ADARs bind RNA? New protein-RNA structures illuminate substrate recognition by the RNA editing ADARs. Bioessays. 2017 04; 39(4). Thomas JM, Beal PA. PMID: 28217931; PMCID: PMC5501306.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    34. Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures. RNA Biol. 2017 02; 14(2):164-170. Fisher AJ, Beal PA. PMID: 27937139; PMCID: PMC5324757.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    35. Guide Strand 3'-End Modifications Regulate siRNA Specificity. Chembiochem. 2016 Dec 14; 17(24):2340-2345. Valenzuela RA, Onizuka K, Ball-Jones AA, Hu T, Suter SR, Beal PA. PMID: 27731539; PMCID: PMC5161629.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    36. Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. Nucleic Acids Res. 2016 Nov 16; 44(20):9872-9880. Wang Y, Beal PA. PMID: 27614075; PMCID: PMC5175354.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    37. Structure-Guided Control of siRNA Off-Target Effects. J Am Chem Soc. 2016 07 20; 138(28):8667-9. Suter SR, Sheu-Gruttadauria J, Schirle NT, Valenzuela R, Ball-Jones AA, Onizuka K, MacRae IJ, Beal PA. PMID: 27387838; PMCID: PMC4962782.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    38. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol. 2016 05; 23(5):426-33. Matthews MM, Thomas JM, Zheng Y, Tran K, Phelps KJ, Scott AI, Havel J, Fisher AJ, Beal PA. PMID: 27065196; PMCID: PMC4918759.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    39. Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1799-802. Zheng Y, Beal PA. PMID: 26927424; PMCID: PMC4785081.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    40. A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1. ACS Chem Biol. 2015 Nov 20; 10(11):2512-9. Wang Y, Havel J, Beal PA. PMID: 26372505; PMCID: PMC4900682.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8713-6. Mizrahi RA, Shin D, Sinkeldam RW, Phelps KJ, Fin A, Tantillo DJ, Tor Y, Beal PA. PMID: 26095193; PMCID: PMC4532316.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61. Tran K, Arkin MR, Beal PA. PMID: 25749683; PMCID: PMC4760646.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    43. On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Cell. 2015 Feb 12; 160(4):644-658. Kuhn CD, Wilusz JE, Zheng Y, Beal PA, Joshua-Tor L. PMID: 25640237; PMCID: PMC4329729.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    44. Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res. 2015 Jan; 43(2):1123-32. Phelps KJ, Tran K, Eifler T, Erickson AI, Fisher AJ, Beal PA. PMID: 25564529; PMCID: PMC4333395.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    45. Base modification strategies to modulate immune stimulation by an siRNA. Chembiochem. 2015 Jan 19; 16(2):262-7. Valenzuela RA, Suter SR, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Beal PA. PMID: 25487859; PMCID: PMC4337945.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsPHPublic Health
    46. Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem Biol. 2014 Aug 15; 9(8):1780-7. Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA. PMID: 24896732; PMCID: PMC4136661.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    47. Short interfering RNA guide strand modifiers from computational screening. J Am Chem Soc. 2013 Nov 13; 135(45):17069-77. Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA. PMID: 24152142; PMCID: PMC3884816.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    48. RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae. Biochemistry. 2013 Nov 12; 52(45):7857-69. Eifler T, Pokharel S, Beal PA. PMID: 24124932; PMCID: PMC3856204.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    49. Computational approaches to predicting the impact of novel bases on RNA structure and stability. ACS Chem Biol. 2013 Nov 15; 8(11):2354-9. Harrison JG, Zheng YB, Beal PA, Tantillo DJ. PMID: 24063428; PMCID: PMC3856235.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    50. Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides. ACS Chem Biol. 2013 Apr 19; 8(4):832-9. Mizrahi RA, Schirle NT, Beal PA. PMID: 23394403; PMCID: PMC3631459.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    51. A screening protocol for identification of functional mutants of RNA editing adenosine deaminases. Curr Protoc Chem Biol. 2012 Dec 01; 4(4):357-69. Eifler T, Chan D, Beal PA. PMID: 23788559; PMCID: PMC3690185.
      View in: PubMed   Mentions: 2     Fields:    
    52. Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding. J Am Chem Soc. 2012 Oct 24; 134(42):17643-52. Ghanty U, Fostvedt E, Valenzuela R, Beal PA, Burrows CJ. PMID: 23030736; PMCID: PMC3491887.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    53. Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases. Nucleic Acids Res. 2012 Oct; 40(19):9825-35. Mizrahi RA, Phelps KJ, Ching AY, Beal PA. PMID: 22885375; PMCID: PMC3479202.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    54. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. PMID: 22766576; PMCID: PMC3417767.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    55. NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing. Chembiochem. 2012 Jun 18; 13(9):1338-48. Onizuka K, Yeo J, David SS, Beal PA. PMID: 22639086; PMCID: PMC3454477.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    56. ADAR proteins: structure and catalytic mechanism. Curr Top Microbiol Immunol. 2012; 353:1-33. Goodman RA, Macbeth MR, Beal PA. PMID: 21769729.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    57. Novel modifications in RNA. ACS Chem Biol. 2012 Jan 20; 7(1):100-9. Phelps K, Morris A, Beal PA. PMID: 22148740; PMCID: PMC3270579.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    58. Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem. 2011 Sep 16; 76(18):7295-300. Peacock H, Kannan A, Beal PA, Burrows CJ. PMID: 21834582; PMCID: PMC3170502.
      View in: PubMed   Mentions: 28     Fields:    
    59. Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc. 2011 Jun 22; 133(24):9200-3. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA. PMID: 21612237; PMCID: PMC3116021.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    60. Covalent stabilization of a small molecule-RNA complex. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5002-5. Peacock H, Bachu R, Beal PA. PMID: 21601451; PMCID: PMC3156283.
      View in: PubMed   Mentions: 5     Fields:    
    61. 8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves. J Am Chem Soc. 2011 Apr 27; 133(16):6343-51. Kannan A, Fostvedt E, Beal PA, Burrows CJ. PMID: 21452817; PMCID: PMC3086133.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    62. RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20715-9. Yeo J, Goodman RA, Schirle NT, David SS, Beal PA. PMID: 21068368; PMCID: PMC2996456.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    63. Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs. ACS Chem Biol. 2010 Dec 17; 5(12):1115-24. Peacock H, Fostvedt E, Beal PA. PMID: 20863128; PMCID: PMC3003776.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    64. Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide. Org Biomol Chem. 2010 Nov 07; 8(21):4898-904. Schirle NT, Goodman RA, Krishnamurthy M, Beal PA. PMID: 20820662.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    65. N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA. Org Lett. 2010 Mar 05; 12(5):1044-7. Peacock H, Maydanovych O, Beal PA. PMID: 20108910; PMCID: PMC2830388.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    66. Covalent hydration energies for purine analogs by quantum chemical methods. J Comput Chem. 2010 Mar; 31(4):721-5. Wang SC, Beal PA, Tantillo DJ. PMID: 19569207.
      View in: PubMed   Mentions: 3     Fields:    
    67. Matching active site and substrate structures for an RNA editing reaction. J Am Chem Soc. 2009 Aug 26; 131(33):11882-91. Pokharel S, Jayalath P, Maydanovych O, Goodman RA, Wang SC, Tantillo DJ, Beal PA. PMID: 19642681.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    68. Synthesis and evaluation of an RNA editing substrate bearing 2'-deoxy-2'-mercaptoadenosine. Nucleosides Nucleotides Nucleic Acids. 2009 Feb; 28(2):78-88. Jayalath P, Pokharel S, Véliz E, Beal PA. PMID: 19219738; PMCID: PMC2747504.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    69. Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. Bioorg Med Chem. 2008 Oct 01; 16(19):8914-21. Krishnamurthy M, Schirle NT, Beal PA. PMID: 18789700; PMCID: PMC2585546.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    70. Macrocyclic helix-threading peptides for targeting RNA. Angew Chem Int Ed Engl. 2007; 46(37):7044-7. Krishnamurthy M, Simon K, Orendt AM, Beal PA. PMID: 17691090.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    71. Probing adenosine-to-inosine editing reactions using RNA-containing nucleoside analogs. Methods Enzymol. 2007; 424:369-86. Maydanovych O, Easterwood LM, Cui T, Véliz EA, Pokharel S, Beal PA. PMID: 17662850.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    72. The chemistry and biology of RNA editing by adenosine deaminases. Nucleic Acids Symp Ser (Oxf). 2007; (51):83-4. Beal PA, Maydanovych O, Pokharel S. PMID: 18029597.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    73. High-throughput screening for functional adenosine to inosine RNA editing systems. ACS Chem Biol. 2006 Dec 15; 1(12):761-5. Pokharel S, Beal PA. PMID: 17240974.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    74. Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res. 2006; 34(17):4900-11. Puthenveetil S, Whitby L, Ren J, Kelnar K, Krebs JF, Beal PA. PMID: 16982647; PMCID: PMC1635244.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    75. C6-substituted analogues of 8-azanebularine: probes of an RNA-editing enzyme active site. Org Lett. 2006 Aug 17; 8(17):3753-6. Maydanovych O, Beal PA. PMID: 16898809.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    76. Breaking the central dogma by RNA editing. Chem Rev. 2006 Aug; 106(8):3397-411. Maydanovych O, Beal PA. PMID: 16895334.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    77. RNA binding and thiolytic stability of a quinoline-containing helix-threading peptide. Org Biomol Chem. 2006 Feb 21; 4(4):639-45. Krishnamurthy M, Gooch BD, Beal PA. PMID: 16467938.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    78. Binding of helix-threading peptides to E. coli 16S ribosomal RNA and inhibition of the S15-16S complex. Chembiochem. 2005 Dec; 6(12):2247-54. Gooch BD, Krishnamurthy M, Shadid M, Beal PA. PMID: 16245373.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    79. Duplex RNA-binding enzymes: headliners from neurobiology, virology, and development. Chembiochem. 2005 Feb; 6(2):257-66. Beal PA. PMID: 15645515.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    80. Inhibitory properties of nucleic acid-binding ligands on protein synthesis. FEBS Lett. 2005 Jan 03; 579(1):79-89. Malina A, Khan S, Carlson CB, Svitkin Y, Harvey I, Sonenberg N, Beal PA, Pelletier J. PMID: 15620694.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    81. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004 Sep 15; 126(36):11213-9. Haudenschild BL, Maydanovych O, Véliz EA, Macbeth MR, Bass BL, Beal PA. PMID: 15355102; PMCID: PMC1823040.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    82. The binding selectivity of ADAR2's dsRBMs contributes to RNA-editing selectivity. Chem Biol. 2004 Sep; 11(9):1239-50. Stephens OM, Haudenschild BL, Beal PA. PMID: 15380184.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    83. Recognition of duplex RNA by helix-threading peptides. J Am Chem Soc. 2004 Sep 01; 126(34):10603-10. Gooch BD, Beal PA. PMID: 15327318.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    84. Site-specific modification of Epstein-Barr virus-encoded RNA 1 with N2-benzylguanosine limits the binding sites occupied by PKR. Chembiochem. 2004 Mar 05; 5(3):383-6. Puthenveetil S, Véliz EA, Beal PA. PMID: 14997533.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    85. Peptide quinoline conjugates: a new class of RNA-binding molecules. Org Lett. 2004 Jan 08; 6(1):63-6. Krishnamurthy M, Gooch BD, Beal PA. PMID: 14703351.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    86. Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design. J Am Chem Soc. 2003 Sep 10; 125(36):10867-76. Véliz EA, Easterwood LM, Beal PA. PMID: 12952466.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    87. Recognition of double-stranded RNA by proteins and small molecules. Biopolymers. 2003 Sep; 70(1):86-102. Carlson CB, Stephens OM, Beal PA. PMID: 12925995.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    88. Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun. 2003 Aug 15; 308(1):50-7. Jammi NV, Whitby LR, Beal PA. PMID: 12890478.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    89. Preferred RNA binding sites for a threading intercalator revealed by in vitro evolution. Chem Biol. 2003 Jul; 10(7):663-72. Carlson CB, Vuyisich M, Gooch BD, Beal PA. PMID: 12890540.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    90. Selection of small-molecule mediators of the RNA regulation of PKR, the RNA-dependent protein kinase. Chembiochem. 2002 Sep 02; 3(9):859-65. Carlson CB, Spanggord RJ, Beal PA. PMID: 12210987.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    91. Point of attachment and sequence of immobilized peptide-acridine conjugates control affinity for nucleic acids. J Am Chem Soc. 2002 Jul 24; 124(29):8510-1. Carlson CB, Beal PA. PMID: 12121075.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    92. The binding site of the RNA-dependent protein kinase (PKR) on EBER1 RNA from Epstein-Barr virus. EMBO Rep. 2002 Jul; 3(7):622-7. Vuyisich M, Spanggord RJ, Beal PA. PMID: 12101093; PMCID: PMC1084191.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    93. Identification of binding sites for both dsRBMs of PKR on kinase-activating and kinase-inhibiting RNA ligands. Biochemistry. 2002 Apr 09; 41(14):4511-20. Spanggord RJ, Vuyisich M, Beal PA. PMID: 11926812.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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