Peter A Beal

Title(s)PROF-AY, Chemistry
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    Collapse Research 
    Collapse Research Activities and Funding
    UC Davis Training Program in Chemical Biology
    NIH/NIGMS T32GM113770Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Nucleobase analog for the next generation siRNa
    NIH/NIGMS R01GM080784Apr 1, 2007 - Aug 31, 2021
    Role: Principal Investigator
    RNA-specific ligands: An Approach to New Antivirals
    NIH/NIAID R21AI049062Jan 1, 2001 - Aug 31, 2005
    Role: Principal Investigator
    NIH/NIAID R01AI049062Jan 1, 2001 - Dec 31, 2004
    Role: Principal Investigator
    The Bioorganic Chemistry of RNA editing by ADARs
    NIH/NIGMS R01GM061115Apr 1, 2000 - Jul 31, 2019
    Role: Principal Investigator
    RNA-regulation and signal transduction by PKR
    NIH/NIGMS R01GM057214May 1, 1998 - Apr 30, 2008
    Role: Co-Principal Investigator
    NIH/NCI F32CA062585Sep 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. A Bump-Hole Approach for Directed RNA Editing. Cell Chem Biol. 2019 Feb 21; 26(2):269-277.e5. PMID: 30581135.
      View in: PubMed
    2. Palumbo CM, Beal PA. Nucleoside analogs in the study of the epitranscriptome. Methods. 2019 Mar 01; 156:46-52. PMID: 30827466.
      View in: PubMed
    3. Fisher AJ, Beal PA. Structural basis for eukaryotic mRNA modification. Curr Opin Struct Biol. 2018 Dec; 53:59-68. PMID: 29913347.
      View in: PubMed
    4. Wang Y, Park S, Beal PA. Selective Recognition of RNA Substrates by ADAR Deaminase Domains. Biochemistry. 2018 03 13; 57(10):1640-1651. PMID: 29457714.
      View in: PubMed
    5. Suter SR, Ball-Jones A, Mumbleau MM, Valenzuela R, Ibarra-Soza J, Owens H, Fisher AJ, Beal PA. Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. Org Biomol Chem. 2017 Dec 06; 15(47):10029-10036. PMID: 29164215.
      View in: PubMed
    6. Hu T, Suter SR, Mumbleau MM, Beal PA. TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length. Bioorg Med Chem. 2018 01 01; 26(1):77-83. PMID: 29174509.
      View in: PubMed
    7. Zheng Y, Lorenzo C, Beal PA. DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. Nucleic Acids Res. 2017 Apr 07; 45(6):3369-3377. PMID: 28132026.
      View in: PubMed
    8. Fisher AJ, Beal PA. Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures. RNA Biol. 2017 02; 14(2):164-170. PMID: 27937139.
      View in: PubMed
    9. Valenzuela RA, Onizuka K, Ball-Jones AA, Hu T, Suter SR, Beal PA. Guide Strand 3'-End Modifications Regulate siRNA Specificity. Chembiochem. 2016 Dec 14; 17(24):2340-2345. PMID: 27731539.
      View in: PubMed
    10. Wang Y, Beal PA. Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. Nucleic Acids Res. 2016 Nov 16; 44(20):9872-9880. PMID: 27614075.
      View in: PubMed
    11. Suter SR, Sheu-Gruttadauria J, Schirle NT, Valenzuela R, Ball-Jones AA, Onizuka K, MacRae IJ, Beal PA. Structure-Guided Control of siRNA Off-Target Effects. J Am Chem Soc. 2016 07 20; 138(28):8667-9. PMID: 27387838.
      View in: PubMed
    12. Matthews MM, Thomas JM, Zheng Y, Tran K, Phelps KJ, Scott AI, Havel J, Fisher AJ, Beal PA. Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol. 2016 05; 23(5):426-33. PMID: 27065196; PMCID: PMC4918759 [Available on 10/11/16].
    13. Zheng Y, Beal PA. Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1799-802. PMID: 26927424; PMCID: PMC4785081 [Available on 04/01/17].
    14. Wang Y, Havel J, Beal PA. A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1. ACS Chem Biol. 2015 Nov 20; 10(11):2512-9. PMID: 26372505; PMCID: PMC4900682 [Available on 11/20/16].
    15. Mizrahi RA, Shin D, Sinkeldam RW, Phelps KJ, Fin A, Tantillo DJ, Tor Y, Beal PA. A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8713-6. PMID: 26095193; PMCID: PMC4532316.
    16. Tran K, Arkin MR, Beal PA. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61. PMID: 25749683; PMCID: PMC4760646.
    17. Phelps KJ, Tran K, Eifler T, Erickson AI, Fisher AJ, Beal PA. Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res. 2015 Jan; 43(2):1123-32. PMID: 25564529; PMCID: PMC4333395.
    18. Valenzuela RA, Suter SR, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Beal PA. Base modification strategies to modulate immune stimulation by an siRNA. Chembiochem. 2015 Jan 19; 16(2):262-7. PMID: 25487859; PMCID: PMC4337945.
    19. Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA. Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem Biol. 2014 Aug 15; 9(8):1780-7. PMID: 24896732.
      View in: PubMed
    20. Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA. Short interfering RNA guide strand modifiers from computational screening. J Am Chem Soc. 2013 Nov 13; 135(45):17069-77. PMID: 24152142; PMCID: PMC3884816.
    21. Eifler T, Pokharel S, Beal PA. RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae. Biochemistry. 2013 Nov 12; 52(45):7857-69. PMID: 24124932; PMCID: PMC3856204.
    22. Harrison JG, Zheng YB, Beal PA, Tantillo DJ. Computational approaches to predicting the impact of novel bases on RNA structure and stability. ACS Chem Biol. 2013 Nov 15; 8(11):2354-9. PMID: 24063428; PMCID: PMC3856235.
    23. Mizrahi RA, Schirle NT, Beal PA. Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides. ACS Chem Biol. 2013 Apr 19; 8(4):832-9. PMID: 23394403; PMCID: PMC3631459.
    24. Ghanty U, Fostvedt E, Valenzuela R, Beal PA, Burrows CJ. Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding. J Am Chem Soc. 2012 Oct 24; 134(42):17643-52. PMID: 23030736; PMCID: PMC3491887.
    25. Mizrahi RA, Phelps KJ, Ching AY, Beal PA. Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases. Nucleic Acids Res. 2012 Oct; 40(19):9825-35. PMID: 22885375; PMCID: PMC3479202.
    26. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. 7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. PMID: 22766576; PMCID: PMC3417767.
    27. Onizuka K, Yeo J, David SS, Beal PA. NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing. Chembiochem. 2012 Jun 18; 13(9):1338-48. PMID: 22639086.
      View in: PubMed
    28. Goodman RA, Macbeth MR, Beal PA. ADAR proteins: structure and catalytic mechanism. Curr Top Microbiol Immunol. 2012; 353:1-33. PMID: 21769729.
      View in: PubMed
    29. Phelps K, Morris A, Beal PA. Novel modifications in RNA. ACS Chem Biol. 2012 Jan 20; 7(1):100-9. PMID: 22148740; PMCID: PMC3270579.
    30. Peacock H, Kannan A, Beal PA, Burrows CJ. Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem. 2011 Sep 16; 76(18):7295-300. PMID: 21834582; PMCID: PMC3170502.
    31. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA. Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc. 2011 Jun 22; 133(24):9200-3. PMID: 21612237; PMCID: PMC3116021.
    32. Peacock H, Bachu R, Beal PA. Covalent stabilization of a small molecule-RNA complex. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5002-5. PMID: 21601451; PMCID: PMC3156283.
    33. Yeo J, Goodman RA, Schirle NT, David SS, Beal PA. RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20715-9. PMID: 21068368; PMCID: PMC2996456.
    34. Peacock H, Fostvedt E, Beal PA. Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs. ACS Chem Biol. 2010 Dec 17; 5(12):1115-24. PMID: 20863128; PMCID: PMC3003776.
    35. Schirle NT, Goodman RA, Krishnamurthy M, Beal PA. Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide. Org Biomol Chem. 2010 Nov 07; 8(21):4898-904. PMID: 20820662.
      View in: PubMed
    36. Peacock H, Maydanovych O, Beal PA. N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA. Org Lett. 2010 Mar 05; 12(5):1044-7. PMID: 20108910; PMCID: PMC2830388.
    37. Wang SC, Beal PA, Tantillo DJ. Covalent hydration energies for purine analogs by quantum chemical methods. J Comput Chem. 2010 Mar; 31(4):721-5. PMID: 19569207.
      View in: PubMed
    38. Jayalath P, Pokharel S, Véliz E, Beal PA. Synthesis and evaluation of an RNA editing substrate bearing 2'-deoxy-2'-mercaptoadenosine. Nucleosides Nucleotides Nucleic Acids. 2009 Feb; 28(2):78-88. PMID: 19219738; PMCID: PMC2747504.
    39. Krishnamurthy M, Schirle NT, Beal PA. Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. Bioorg Med Chem. 2008 Oct 01; 16(19):8914-21. PMID: 18789700; PMCID: PMC2585546.
    40. Beal PA, Maydanovych O, Pokharel S. The chemistry and biology of RNA editing by adenosine deaminases. Nucleic Acids Symp Ser (Oxf). 2007; (51):83-4. PMID: 18029597.
      View in: PubMed
    41. Krishnamurthy M, Simon K, Orendt AM, Beal PA. Macrocyclic helix-threading peptides for targeting RNA. Angew Chem Int Ed Engl. 2007; 46(37):7044-7. PMID: 17691090.
      View in: PubMed
    42. Krishnamurthy M, Gooch BD, Beal PA. RNA binding and thiolytic stability of a quinoline-containing helix-threading peptide. Org Biomol Chem. 2006 Feb 21; 4(4):639-45. PMID: 16467938.
      View in: PubMed