Justin Siegel

Title(s)Associate Professor, Biochemistry and Molecular Medicine
SchoolSchool of Veterinary Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Discovery of Potent Glycosidases Enables Quantification of Smoke-Derived Phenolic Glycosides through Enzymatic Hydrolysis. J Agric Food Chem. 2024 May 22; 72(20):11617-11628. Cui Y, Riley M, Moreno MV, Cepeda MM, Perez IA, Wen Y, Lim LX, Andre E, Nguyen A, Liu C, Lerno L, Nichols PK, Schmitz H, Tagkopoulos I, Kennedy JA, Oberholster A, Siegel JB. PMID: 38728580; PMCID: PMC11117406.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Docking carbocations into terpene synthase active sites using chemically meaningful constraints-The TerDockin approach. Methods Enzymol. 2024; 699:231-263. Torrence IS, O'Brien TE, Siegel JB, Tantillo DJ. PMID: 38942505.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Acid-active proteases to optimize dietary protein digestibility: a step towards sustainable nutrition. Front Nutr. 2024; 11:1291685. Mak WS, Jones CP, McBride KE, Fritz EAP, Hirsch J, German JB, Siegel JB. PMID: 38389801; PMCID: PMC10881760.
      View in: PubMed   Mentions:
    4. Missing a "Missing Self" Mechanism: Modeling and Detection of Ly49 Expression in Canine NK Cells. Immunohorizons. 2023 Nov 01; 7(11):760-770. Gingrich AA, Razmara AM, Gingrich PW, Rebhun RB, Murphy WJ, Kent MS, Brown CT, Siegel JB, Canter RJ. PMID: 37971282; PMCID: PMC10696421.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Awakening the natural capability of psicose production in Escherichia coli. NPJ Sci Food. 2023 Oct 14; 7(1):54. Taylor JE, Palur DSK, Zhang A, Gonzales JN, Arredondo A, Coulther TA, Lechner ABJ, Rodriguez EP, Fiehn O, Didzbalis J, Siegel JB, Atsumi S. PMID: 37838768; PMCID: PMC10576766.
      View in: PubMed   Mentions:
    6. Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor. bioRxiv. 2023 Aug 30. Aspacio D, Zhang Y, Cui Y, King E, Black WB, Perea S, Luu E, Siegel JB, Li H. PMID: 37693387; PMCID: PMC10491207.
      View in: PubMed   Mentions:
    7. Computational Drug Design of Novel Agonists of the μ -Opioid Receptor to Inhibit Pain Signaling. bioRxiv. 2023 Aug 26. Daoud N, Mateos DL, Riley MA, Siegel JB. PMID: 37662242; PMCID: PMC10473735.
      View in: PubMed   Mentions:
    8. Design to Data for mutants of B-glucosidase B from Paenibacillus polymyxa : V311D, F248N, Y166H, Y166K, M221K. bioRxiv. 2023 May 11. Chan M, Siegel JB, Vater A. PMID: 37214998; PMCID: PMC10197662.
      View in: PubMed   Mentions:
    9. Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase. Nat Commun. 2022 11 26; 13(1):7282. King E, Maxel S, Zhang Y, Kenney KC, Cui Y, Luu E, Siegel JB, Weiss GA, Luo R, Li H. PMID: 36435948; PMCID: PMC9701214.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform. Nat Commun. 2022 08 26; 13(1):5021. Zhang L, King E, Black WB, Heckmann CM, Wolder A, Cui Y, Nicklen F, Siegel JB, Luo R, Paul CE, Li H. PMID: 36028482; PMCID: PMC9418148.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    11. Structural plasticity enables evolution and innovation of RuBisCO assemblies. Sci Adv. 2022 Aug 26; 8(34):eadc9440. Liu AK, Pereira JH, Kehl AJ, Rosenberg DJ, Orr DJ, Chu SKS, Banda DM, Hammel M, Adams PD, Siegel JB, Shih PM. PMID: 36026446; PMCID: PMC9417184.
      View in: PubMed   Mentions: 5     Fields:    
    12. Engineering Embden-Meyerhof-Parnas Glycolysis to Generate Noncanonical Reducing Power. ACS Catal. 2022 Jul 15; 12(14):8582-8592. King E, Cui Y, Aspacio D, Nicklen F, Zhang L, Maxel S, Luo R, Siegel JB, Aitchison E, Li H. PMID: 37622090; PMCID: PMC10449333.
      View in: PubMed   Mentions:
    13. Investigation of Acid-Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence. ACS Bio Med Chem Au. 2022 Oct 19; 2(5):490-498. Lemke C, Roach K, Ortega T, Tantillo DJ, Siegel JB, Peters RJ. PMID: 36281298; PMCID: PMC9585517.
      View in: PubMed   Mentions: 3  
    14. Foodomics: A Data-Driven Approach to Revolutionize Nutrition and Sustainable Diets. Front Nutr. 2022; 9:874312. Ahmed S, de la Parra J, Elouafi I, German B, Jarvis A, Lal V, Lartey A, Longvah T, Malpica C, Vázquez-Manjarrez N, Prenni J, Aguilar-Salinas CA, Srichamnong W, Rajasekharan M, Shafizadeh T, Siegel JB, Steiner R, Tohme J, Watkins S. PMID: 35592635; PMCID: PMC9113044.
      View in: PubMed   Mentions: 8  
    15. The pyruvate decarboxylase activity of IpdC is a limitation for isobutanol production by Klebsiella pneumoniae. Biotechnol Biofuels Bioprod. 2022 May 02; 15(1):41. Shu L, Gu J, Wang Q, Sun S, Cui Y, Fell J, Mak WS, Siegel JB, Shi J, Lye GJ, Baganz F, Hao J. PMID: 35501883; PMCID: PMC9063327.
      View in: PubMed   Mentions:
    16. Assessing Alkene Reactivity toward Cytochrome P450-Mediated Epoxidation through Localized Descriptors and Regression Modeling. J Chem Inf Model. 2022 04 25; 62(8):1979-1987. Gingrich PW, Siegel JB, Tantillo DJ. PMID: 35421306.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Treatment of experimental anthrax with pegylated circularly permuted capsule depolymerase. Sci Transl Med. 2021 12 08; 13(623):eabh1682. Legler PM, Little SF, Senft J, Schokman R, Carra JH, Compton JR, Chabot D, Tobery S, Fetterer DP, Siegel JB, Baker D, Friedlander AM. PMID: 34878819.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nat Commun. 2021 11 29; 12(1):6947. Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetic A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, Ó Conchúir S, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, Bahl CD, Bailey-Kellogg C, Baker D, Das R, DiMaio F, Khare SD, Kortemme T, Labonte JW, Lindorff-Larsen K, Meiler J, Schief W, Schueler-Furman O, Siegel JB, Stein A, Yarov-Yarovoy V, Kuhlman B, Leaver-Fay A, Gront D, Gray JJ, Bonneau R. PMID: 34845212; PMCID: PMC8630030.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.). Plant J. 2021 11; 108(4):1053-1068. Muchlinski A, Jia M, Tiedge K, Fell JS, Pelot KA, Chew L, Davisson D, Chen Y, Siegel J, Lovell JT, Zerbe P. PMID: 34514645; PMCID: PMC9292899.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design. Biophysicist (Rockv). 2021 Apr; 2(1):108-122. Le KH, Adolf-Bryfogle J, Klima JC, Lyskov S, Labonte J, Bertolani S, Burman SSR, Leaver-Fay A, Weitzner B, Maguire J, Rangan R, Adrianowycz MA, Alford RF, Adal A, Nance ML, Wu Y, Willis J, Kulp DW, Das R, Dunbrack RL, Schief W, Kuhlman B, Siegel JB, Gray JJ. PMID: 35128343; PMCID: PMC8813091.
      View in: PubMed   Mentions: 4  
    21. Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue. Sci Adv. 2021 04; 7(15). Denish PR, Fenger JA, Powers R, Sigurdson GT, Grisanti L, Guggenheim KG, Laporte S, Li J, Kondo T, Magistrato A, Moloney MP, Riley M, Rusishvili M, Ahmadiani N, Baroni S, Dangles O, Giusti M, Collins TM, Didzbalis J, Yoshida K, Siegel JB, Robbins RJ. PMID: 33827818; PMCID: PMC8026139.
      View in: PubMed   Mentions: 11     Fields:    
    22. Preliminary Techno-Economic Assessment of Animal Cell-Based Meat. Foods. 2020 Dec 22; 10(1). Risner D, Li F, Fell JS, Pace SA, Siegel JB, Tagkopoulos I, Spang ES. PMID: 33374916; PMCID: PMC7821941.
      View in: PubMed   Mentions: 6  
    23. Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c. Biochemistry. 2020 12 01; 59(47):4507-4515. Zhang Y, Prach LM, O'Brien TE, DiMaio F, Prigozhin DM, Corn JE, Alber T, Siegel JB, Tantillo DJ. PMID: 33182997; PMCID: PMC8120997.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    24. High-throughput mutagenesis reveals unique structural features of human ADAR1. Nat Commun. 2020 10 12; 11(1):5130. Park S, Doherty EE, Xie Y, Padyana AK, Fang F, Zhang Y, Karki A, Lebrilla CB, Siegel JB, Beal PA. PMID: 33046702; PMCID: PMC7550611.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily. Biochemistry. 2020 10 13; 59(40):3834-3843. Mak WS, Wang X, Arenas R, Cui Y, Bertolani S, Deng WQ, Tagkopoulos I, Wilson DK, Siegel JB. PMID: 32935984.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    26. Functional characterization and reclassification of an enzyme previously proposed to be a limonoid UDP-glucosyltransferase. J Sci Food Agric. 2020 Oct; 100(13):4870-4878. Cui Y, Allmon SD, Siegel JB. PMID: 32483918; PMCID: PMC7920543.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    27. Macromolecular modeling and design in Rosetta: recent methods and frameworks. Nat Methods. 2020 07; 17(7):665-680. Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, Bradley P, Bystroff C, Conway P, Cooper S, Correia BE, Coventry B, Das R, De Jong RM, DiMaio F, Dsilva L, Dunbrack R, Ford AS, Frenz B, Fu DY, Geniesse C, Goldschmidt L, Gowthaman R, Gray JJ, Gront D, Guffy S, Horowitz S, Huang PS, Huber T, Jacobs TM, Jeliazkov JR, Johnson DK, Kappel K, Karanicolas J, Khakzad H, Khar KR, Khare SD, Khatib F, Khramushin A, King IC, Kleffner R, Koepnick B, Kortemme T, Kuenze G, Kuhlman B, Kuroda D, Labonte JW, Lai JK, Lapidoth G, Leaver-Fay A, Lindert S, Linsky T, London N, Lubin JH, Lyskov S, Maguire J, Malmström L, Marcos E, Marcu O, Marze NA, Meiler J, Moretti R, Mulligan VK, Nerli S, Norn C, Ó'Conchúir S, Ollikainen N, Ovchinnikov S, Pacella MS, Pan X, Park H, Pavlovicz RE, Pethe M, Pierce BG, Pilla KB, Raveh B, Renfrew PD, Burman SSR, Rubenstein A, Sauer MF, Scheck A, Schief W, Schueler-Furman O, Sedan Y, Sevy AM, Sgourakis NG, Shi L, Siegel JB, Silva DA, Smith S, Song Y, Stein A, Szegedy M, Teets FD, Thyme SB, Wang RY, Watkins A, Zimmerman L, Bonneau R. PMID: 32483333; PMCID: PMC7603796.
      View in: PubMed   Mentions: 263     Fields:    Translation:Cells
    28. Evaluating Protein Engineering Thermostability Prediction Tools Using an Independently Generated Dataset. ACS Omega. 2020 Mar 31; 5(12):6487-6493. Huang P, Chu SKS, Frizzo HN, Connolly MP, Caster RW, Siegel JB. PMID: 32258884; PMCID: PMC7114132.
      View in: PubMed   Mentions: 21  
    29. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem. 2020 May 01; 193:112206. Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD. PMID: 32203787; PMCID: PMC7366823.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    30. A Benchmark for Homomeric Enzyme Active Site Structure Prediction Highlights the Importance of Accurate Modeling of Protein Symmetry. ACS Omega. 2019 Dec 31; 4(27):22356-22362. Contreras SC, Bertolani SJ, Siegel JB. PMID: 31909318; PMCID: PMC6941179.
      View in: PubMed   Mentions: 1  
    31. Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis. Nat Chem Biol. 2020 01; 16(1):87-94. Black WB, Zhang L, Mak WS, Maxel S, Cui Y, King E, Fong B, Sanchez Martinez A, Siegel JB, Li H. PMID: 31768035; PMCID: PMC7546441.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    32. Toward Development of Fluorescence-Quenching-Based Biosensors for Drought Stress in Plants. Anal Chem. 2019 12 17; 91(24):15644-15651. Sharmah A, Kraus M, Cutler SR, Siegel JB, Brady SM, Guo T. PMID: 31698903; PMCID: PMC7990104.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Switching on a Nontraditional Enzymatic Base - Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum. ACS Catal. 2019 Oct 04; 9(10):8867-8871. Jia M, Zhang Y, Siegel JB, Tantillo DJ, Peters RJ. PMID: 32489716; PMCID: PMC7266162.
      View in: PubMed   Mentions: 9  
    34. Molecular annotation of food - towards personalized diet and precision health. Trends Food Sci Technol. 2019 Sep; 91:675-680. Gan J, Siegel JB, German JB. PMID: 33299266; PMCID: PMC7723349.
      View in: PubMed   Mentions: 4  
    35. Computer-Aided Drug Design for Undergraduates. Journal of Chemical Education. 2019 May 14; 96(5):920-925. Tantillo TD, Siegel SJ, Saunders SC, Palazzo PT, Painter PP, O’Brien OT, Nuñez NN, Nouri ND, Lodewyk LM, Hudson HB, Hare HS, Davis DR. .
      View in: Publisher Site   Mentions:
    36. A new benchmark illustrates that integration of geometric constraints inferred from enzyme reaction chemistry can increase enzyme active site modeling accuracy. PLoS One. 2019; 14(4):e0214126. Bertolani SJ, Siegel JB. PMID: 30947258; PMCID: PMC6448891.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    37. β-Glucosidase Discovery and Design for the Degradation of Oleuropein. ACS Omega. 2018 Nov 30; 3(11):15754-15762. Guggenheim KG, Crawford LM, Paradisi F, Wang SC, Siegel JB. PMID: 30556012; PMCID: PMC6288900.
      View in: PubMed   Mentions: 2  
    38. The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. J Am Chem Soc. 2018 10 17; 140(41):13260-13271. Nuñez NN, Khuu C, Babu CS, Bertolani SJ, Rajavel AN, Spear JE, Armas JA, Wright JD, Siegel JB, Lim C, David SS. PMID: 30208271; PMCID: PMC6443246.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. X-ray-Mediated Release of Molecules and Engineered Proteins from Nanostructure Surfaces. ACS Appl Mater Interfaces. 2018 Sep 26; 10(38):31860-31864. Su M, Guggenheim KG, Lien J, Siegel JB, Guo T. PMID: 30212177.
      View in: PubMed   Mentions: 2     Fields:    
    40. Repurposing Citizen Science Games as Software Tools for Professional Scientists. FDG. 2018 Aug; 2018. Cooper S, Sterling ALR, Kleffner R, Silversmith WM, Siegel JB. PMID: 30465045; PMCID: PMC6241531.
      View in: PubMed   Mentions: 2  
    41. Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene Synthases-Bornyl Diphosphate Synthase as a Representative Case. ACS Catal. 2018 Apr 06; 8(4):3322-3330. O'Brien TE, Bertolani SJ, Zhang Y, Siegel JB, Tantillo DJ. PMID: 30034923; PMCID: PMC6049084.
      View in: PubMed   Mentions: 14  
    42. Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase. ACS Catal. 2018 Apr 06; 8(4):3133-3137. Jia M, O'Brien TE, Zhang Y, Siegel JB, Tantillo DJ, Peters RJ. PMID: 29713562; PMCID: PMC5921835.
      View in: PubMed   Mentions: 10  
    43. Combination of type II fatty acid biosynthesis enzymes and thiolases supports a functional β-oxidation reversal. Metab Eng. 2018 01; 45:11-19. Clomburg JM, Contreras SC, Chou A, Siegel JB, Gonzalez R. PMID: 29146470.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    44. Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta. Bioinformatics. 2017 Sep 01; 33(17):2765-2767. Kleffner R, Flatten J, Leaver-Fay A, Baker D, Siegel JB, Khatib F, Cooper S. PMID: 28481970; PMCID: PMC5860063.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    45. Elucidating Substrate Promiscuity within the FabI Enzyme Family. ACS Chem Biol. 2017 09 15; 12(9):2465-2473. Freund GS, O'Brien TE, Vinson L, Carlin DA, Yao A, Mak WS, Tagkopoulos I, Facciotti MT, Tantillo DJ, Siegel JB. PMID: 28820936.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. Systematic Functional Analysis of Active-Site Residues in l-Threonine Dehydrogenase from Thermoplasma volcanium. ACS Omega. 2017 Jul 31; 2(7):3308-3314. Desjardins M, Mak WS, O'Brien TE, Carlin DA, Tantillo DJ, Siegel JB. PMID: 31457655; PMCID: PMC6641618.
      View in: PubMed   Mentions: 2  
    47. Thermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designed. PLoS One. 2017; 12(5):e0176255. Carlin DA, Hapig-Ward S, Chan BW, Damrau N, Riley M, Caster RW, Bethards B, Siegel JB. PMID: 28531185; PMCID: PMC5439667.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    48. Engineering a Thermostable Keto Acid Decarboxylase Using Directed Evolution and Computationally Directed Protein Design. ACS Synth Biol. 2017 04 21; 6(4):610-618. Soh LMJ, Mak WS, Lin PP, Mi L, Chen FY, Damoiseaux R, Siegel JB, Liao JC. PMID: 28052191.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    49. Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4. Autophagy. 2016 11; 12(11):2054-2068. Seo E, Woo J, Park E, Bertolani SJ, Siegel JB, Choi D, Dinesh-Kumar SP. PMID: 27540766; PMCID: PMC5103345.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    50. Corrigendum: Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway. Nat Commun. 2016 06 07; 7:11912. Mak WS, Tran S, Marcheschi R, Bertolani S, Thompson J, Baker D, Liao JC, Siegel JB. PMID: 27271283; PMCID: PMC4899625.
      View in: PubMed   Mentions: 1     Fields:    
    51. Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction. Chem Sci. 2016 Jul 01; 7(7):4009-4015. O'Brien TE, Bertolani SJ, Tantillo DJ, Siegel JB. PMID: 30155043; PMCID: PMC6013805.
      View in: PubMed   Mentions: 16  
    52. Erratum: Quantitative functional characterization of conserved molecular interactions in the active site of mannitol 2-dehydrogenase. Protein Sci. 2016 Mar; 25(3):769-70. Lucas JE, Siegel JB. PMID: 26898461; PMCID: PMC4815420.
      View in: PubMed   Mentions:    Fields:    
    53. Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants. PLoS One. 2016; 11(1):e0147596. Carlin DA, Caster RW, Wang X, Betzenderfer SA, Chen CX, Duong VM, Ryklansky CV, Alpekin A, Beaumont N, Kapoor H, Kim N, Mohabbot H, Pang B, Teel R, Whithaus L, Tagkopoulos I, Siegel JB. PMID: 26815142; PMCID: PMC4729467.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    54. Computational Introduction of Catalytic Activity into Proteins. Methods Mol Biol. 2016; 1414:213-31. Bertolani SJ, Carlin DA, Siegel JB. PMID: 27094294.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    55. Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway. Nat Commun. 2015 Nov 24; 6:10005. Mak WS, Tran S, Marcheschi R, Bertolani S, Thompson J, Baker D, Liao JC, Siegel JB. PMID: 26598135; PMCID: PMC4673503.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    56. Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions. J Am Chem Soc. 2015 Oct 14; 137(40):13106-13. Wolf C, Siegel JB, Tinberg C, Camarca A, Gianfrani C, Paski S, Guan R, Montelione G, Baker D, Pultz IS. PMID: 26374198; PMCID: PMC4958374.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    57. Mechanistic Analysis of an Engineered Enzyme that Catalyzes the Formose Reaction. Chembiochem. 2015 Sep 07; 16(13):1950-1954. Poust S, Piety J, Bar-Even A, Louw C, Baker D, Keasling JD, Siegel JB. PMID: 26109266.
      View in: PubMed   Mentions: 7     Fields:    
    58. RiboTALE: A modular, inducible system for accurate gene expression control. Sci Rep. 2015 May 29; 5:10658. Rai N, Ferreiro A, Neckelmann A, Soon A, Yao A, Siegel J, Facciotti MT, Tagkopoulos I. PMID: 26023068; PMCID: PMC4650599.
      View in: PubMed   Mentions: 2     Fields:    
    59. Quantitative functional characterization of conserved molecular interactions in the active site of mannitol 2-dehydrogenase. Protein Sci. 2015 Jun; 24(6):936-45. Lucas JE, Siegel JB. PMID: 25752240; PMCID: PMC4456107.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    60. Reassigning the Structures of Natural Products Using NMR Chemical Shifts Computed with Quantum Mechanics: A Laboratory Exercise. Journal of Chemical Education. 2015 Mar 10; 92(3):561-566. Palazzo PT, Truong TT, Wong WS, Mack ME, Lodewyk LM, Harrison HJ, Gamage GR, Siegel SJ, Kurth KM, Tantillo TD. .
      View in: Publisher Site   Mentions:
    61. Computational protein design enables a novel one-carbon assimilation pathway. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3704-9. Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E, Gallaher JL, Bale J, Yoshikuni Y, Gelb MH, Keasling JD, Stoddard BL, Lidstrom ME, Baker D. PMID: 25775555; PMCID: PMC4378393.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    62. Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase. Chem Commun (Camb). 2015 Feb 11; 51(12):2283-5. Carlin DA, Bertolani SJ, Siegel JB. PMID: 25558486.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    63. Computational enzyme design: transitioning from catalytic proteins to enzymes. Curr Opin Struct Biol. 2014 Aug; 27:87-94. Mak WS, Siegel JB. PMID: 25005925.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    64. Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8013-8. Preiswerk N, Beck T, Schulz JD, Milovník P, Mayer C, Siegel JB, Baker D, Hilvert D. PMID: 24847076; PMCID: PMC4050586.
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