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Robert B Rebhun

Title(s)Associate Professor, SCHOOL OF VETERINARY MEDICINE
SchoolUniversity of California, Davis
Phone530-754-5028
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    Collapse Research 
    Collapse Research Activities and Funding
    Enhancing natural killer immunotherapy with first-in-dog trials of inhaled recombinant IL-15 and super-agonist IL-15 in naturally occurring canine cancers
    NIH/NCI U01CA224166Sep 30, 2017 - Aug 31, 2020
    Role: Co-Principal Investigator
    The relationship between epidermal growth factor receptor and hedgehog signaling
    NIH K01OD011111Jul 15, 2011 - May 31, 2016
    Role: Principal Investigator
    The relationship between epidermal growth factor receptor and hedgehog signaling
    NIH/NCRR K01RR031272Jul 15, 2011 - May 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Griffin MA, Culp WTN, Giuffrida MA, Ellis P, Tuohy J, Perry JA, Gedney A, Lux CN, Milovancev M, Wallace ML, Hash J, Mathews K, Liptak JM, Selmic LE, Singh A, Palm CA, Balsa IM, Mayhew PD, Steffey MA, Rebhun RB, Burton JH, Kent MS. Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases. J Vet Intern Med. 2019 Nov 13. PMID: 31721288.
      View in: PubMed
    2. Culp WTN, Johnson EG, Giuffrida MA, Palm CA, Mayhew PD, Kent MS, Rebhun RB, Burton JH. Use of transrectal ultrasonography for assessment of the size and location of prostatic carcinoma in dogs. Am J Vet Res. 2019 Nov; 80(11):1012-1019. PMID: 31644342.
      View in: PubMed
    3. Nam A, Kim T, Li Q, Rebhun RB, Youn HY, Seo KW. Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling. J Vet Med Sci. 2019 Oct 22. PMID: 31645504.
      View in: PubMed
    4. Kent MS, Emami S, Rebhun R, Theon A, Hansen K, Sparger E. The effects of local irradiation on circulating lymphocytes in dogs receiving fractionated radiotherapy. Vet Comp Oncol. 2019 Aug 19. PMID: 31424596.
      View in: PubMed
    5. Withers SS, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Burton JH, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma. Vet Comp Oncol. 2019 Sep; 17(3):242-252. PMID: 30684301.
      View in: PubMed
    6. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Döring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. PLoS Genet. 2018 12; 14(12):e1007850. PMID: 30521570.
      View in: PubMed
    7. Seo KW, Hong H, An SA, Lee JK, Rebhun R. Secondary inappropriate polycythemia with splenic hemangiosarcoma in a young adult cat. Can Vet J. 2018 12; 59(12):1320-1324. PMID: 30532290.
      View in: PubMed
    8. Griffin MA, Culp WTN, Rebhun RB. Lower Urinary Tract Neoplasia. Vet Sci. 2018 Nov 27; 5(4). PMID: 30486368.
      View in: PubMed
    9. Al-Nadaf S, Rebhun RB, Curran KM, Venable RO, Skorupski KA, Willcox JL, Burton JH. Retrospective analysis of doxorubicin and prednisone as first-line therapy for canine B-cell lymphoma. BMC Vet Res. 2018 Nov 20; 14(1):356. PMID: 30458771.
      View in: PubMed
    10. Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019 01; 25(1):141-151. PMID: 30420753.
      View in: PubMed
    11. Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB. Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol. 2019 Mar; 17(1):49-60. PMID: 30156029.
      View in: PubMed
    12. Shin H, Nam A, Song KH, Lee K, Rebhun RB, Seo KW. Anticancer effects of high-dose ascorbate on canine melanoma cell lines. Vet Comp Oncol. 2018 Dec; 16(4):616-621. PMID: 30188000.
      View in: PubMed
    13. Withers SS, York D, Johnson E, Al-Nadaf S, Skorupski KA, Rodriguez CO, Burton JH, Guerrero T, Sein K, Wittenburg L, Rebhun RB. In vitro and in vivo activity of liposome-encapsulated curcumin for naturally occurring canine cancers. Vet Comp Oncol. 2018 Dec; 16(4):571-579. PMID: 30088848.
      View in: PubMed
    14. Skorupski KA, Alarcón CN, de Lorimier LP, LaDouceur EEB, Rodriguez CO, Rebhun RB. Outcome and clinical, pathological, and immunohistochemical factors associated with prognosis for dogs with early-stage anal sac adenocarcinoma treated with surgery alone: 34 cases (2002-2013). J Am Vet Med Assoc. 2018 Jul 01; 253(1):84-91. PMID: 29911942.
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    15. Withers SS, Moore PF, Chang H, Choi JW, McSorley SJ, Kent MS, Monjazeb AM, Canter RJ, Murphy WJ, Sparger EE, Rebhun RB. Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Dev Comp Immunol. 2018 10; 87:64-74. PMID: 29859828.
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    16. Kent MS, Burton JH, Dank G, Bannasch DL, Rebhun RB. Association of cancer-related mortality, age and gonadectomy in golden retriever dogs at a veterinary academic center (1989-2016). PLoS One. 2018; 13(2):e0192578. PMID: 29408871.
      View in: PubMed
    17. Moore EL, Vernau W, Rebhun RB, Skorupski KA, Burton JH. Patient characteristics, prognostic factors and outcome of dogs with high-grade primary mediastinal lymphoma. Vet Comp Oncol. 2018 Mar; 16(1):E45-E51. PMID: 28660709.
      View in: PubMed
    18. Murphy BG, Mok MY, York D, Rebhun R, Woolard KD, Hillman C, Dickinson P, Skorupski K. Evaluation of P16 expression in canine appendicular osteosarcoma. BMC Vet Res. 2017 Jun 20; 13(1):189. PMID: 28633676.
      View in: PubMed
    19. Burton JH, Knych HK, Stanley SD, Rebhun RB. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide. Vet Comp Oncol. 2017 Dec; 15(4):1558-1563. PMID: 28120478.
      View in: PubMed
    20. Park JS, Withers SS, Modiano JF, Kent MS, Chen M, Luna JI, Culp WTN, Sparger EE, Rebhun RB, Monjazeb AM, Murphy WJ, Canter RJ. Canine cancer immunotherapy studies: linking mouse and human. J Immunother Cancer. 2016; 4:97. PMID: 28031824.
      View in: PubMed
    21. York D, Withers SS, Watson KD, Seo KW, Rebhun RB. Enrofloxacin enhances the effects of chemotherapy in canine osteosarcoma cells with mutant and wild-type p53. Vet Comp Oncol. 2017 Sep; 15(3):1087-1100. PMID: 27333821.
      View in: PubMed
    22. Withers SS, Lawson CM, Burton AG, Rebhun RB, Steffey MA. Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. Can Vet J. 2016 Mar; 57(3):299-304. PMID: 26933269.
      View in: PubMed
    23. Rebhun RB, Kass PH, Kent MS, Watson KD, Withers SS, Culp WTN, King AM. Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs. Vet Comp Oncol. 2017 Jun; 15(2):441-449. PMID: 26762869.
      View in: PubMed
    24. Burton JH, Stanley SD, Knych HK, Rodriguez CO, Skorupski KA, Rebhun RB. Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. J Vet Intern Med. 2016 Jan-Feb; 30(1):242-6. PMID: 26682700.
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    25. Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. Companion animals: Translational scientist's new best friends. Sci Transl Med. 2015 Oct 07; 7(308):308ps21. PMID: 26446953.
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    26. Shahi MH, York D, Gandour-Edwards R, Withers SS, Holt R, Rebhun RB. BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance. PLoS One. 2015; 10(6):e0131006. PMID: 26110620.
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    27. Collette SA, Allstadt SD, Chon EM, Vernau W, Smith AN, Garrett LD, Choy K, Rebhun RB, Rodriguez CO, Skorupski KA. Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012). Vet Comp Oncol. 2016 Aug; 14 Suppl 1:136-46. PMID: 26109275.
      View in: PubMed
    28. Budreckis DM, Byrne BA, Pollard RE, Rebhun RB, Rodriguez CO, Skorupski KA. Bacterial urinary tract infections associated with transitional cell carcinoma in dogs. J Vet Intern Med. 2015 May-Jun; 29(3):828-33. PMID: 25940672.
      View in: PubMed
    29. Allstadt SD, Rodriguez CO, Boostrom B, Rebhun RB, Skorupski KA. Randomized phase III trial of piroxicam in combination with mitoxantrone or carboplatin for first-line treatment of urogenital tract transitional cell carcinoma in dogs. J Vet Intern Med. 2015 Jan; 29(1):261-7. PMID: 25619518.
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    30. Shahi MH, Zazpe I, Afzal M, Sinha S, Rebhun RB, Meléndez B, Rey JA, Castresana JS. Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples. Tumour Biol. 2015 Apr; 36(4):2383-91. PMID: 25416442.
      View in: PubMed
    31. Culp WT, Olea-Popelka F, Sefton J, Aldridge CF, Withrow SJ, Lafferty MH, Rebhun RB, Kent MS, Ehrhart N. Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997-2008). J Am Vet Med Assoc. 2014 Nov 15; 245(10):1141-6. PMID: 25356715.
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    32. Withers SS, Kass PH, Rodriguez CO, Skorupski KA, O'Brien D, Guerrero TA, Sein KD, Rebhun RB. Fasting Reduces the Incidence of Delayed-Type Vomiting Associated with Doxorubicin Treatment in Dogs with Lymphoma. Transl Oncol. 2014 May 12. PMID: 24831580.
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    33. Shahi MH, Holt R, Rebhun RB. Blocking signaling at the level of GLI regulates downstream gene expression and inhibits proliferation of canine osteosarcoma cells. PLoS One. 2014; 9(5):e96593. PMID: 24810746.
      View in: PubMed
    34. Seo KW, Coh YR, Rebhun RB, Ahn JO, Han SM, Lee HW, Youn HY. Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines. Res Vet Sci. 2014 Jun; 96(3):482-6. PMID: 24656746.
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    35. Skorupski KA, Uhl JM, Szivek A, Allstadt Frazier SD, Rebhun RB, Rodriguez CO. Carboplatin versus alternating carboplatin and doxorubicin for the adjuvant treatment of canine appendicular osteosarcoma: a randomized, phase III trial. Vet Comp Oncol. 2016 Mar; 14(1):81-7. PMID: 24118677.
      View in: PubMed
    36. O'Brien D, Moore PF, Vernau W, Peauroi JR, Rebhun RB, Rodriguez CO, Skorupski KA. Clinical characteristics and outcome in dogs with splenic marginal zone lymphoma. J Vet Intern Med. 2013 Jul-Aug; 27(4):949-54. PMID: 23734665.
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    37. Lejeune A, Skorupski K, Frazier S, Vanhaezebrouck I, Rebhun RB, Reilly CM, Rodriguez CO. Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012). Vet Comp Oncol. 2015 Sep; 13(3):267-80. PMID: 23721492.
      View in: PubMed
    38. Lux CN, Culp WT, Mayhew PD, Tong K, Rebhun RB, Kass PH. Perioperative outcome in dogs with hemoperitoneum: 83 cases (2005-2010). J Am Vet Med Assoc. 2013 May 15; 242(10):1385-91. PMID: 23634683.
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    39. Culp WT, Ehrhart N, Withrow SJ, Rebhun RB, Boston S, Buracco P, Reiter AM, Schallberger SP, Aldridge CF, Kent MS, Mayhew PD, Brown DC. Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases (1995-2008). J Am Vet Med Assoc. 2013 May 15; 242(10):1392-7. PMID: 23634684.
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    40. Boostrom BO, Good KL, Maggs DJ, Rebhun RB, Johns JL, Kent MS. Unilateral intraocular mastocytosis and anterior uveitis in a dog with subcutaneous mast cell tumors. Vet Ophthalmol. 2014 Mar; 17(2):131-8. PMID: 23578200.
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    41. Withers SS, Johnson EG, Culp WT, Rodriguez CO, Skorupski KA, Rebhun RB. Paraneoplastic hypertrophic osteopathy in 30 dogs. Vet Comp Oncol. 2015 Sep; 13(3):157-65. PMID: 23489591.
      View in: PubMed
    42. Seo Kw, Holt R, Jung YS, Rodriguez CO, Chen X, Rebhun RB. Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. PLoS One. 2012; 7(8):e42960. PMID: 22927942.
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    43. Rebhun RB, Kent MS, Borrofka SA, Frazier S, Skorupski K, Rodriguez CO. CHOP chemotherapy for the treatment of canine multicentric T-cell lymphoma. Vet Comp Oncol. 2011 Mar; 9(1):38-44. PMID: 21303452.
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    44. Balhorn RL, Skorupski KA, Hok S, Balhorn MC, Guerrero T, Rebhun RB. A selective high affinity ligand (SHAL) designed to bind to an over-expressed human antigen on non-Hodgkin's lymphoma also binds to canine B-cell lymphomas. Vet Immunol Immunopathol. 2010 Oct 15; 137(3-4):235-42. PMID: 20576295.
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    45. Rebhun RB, Cheng H, Gershenwald JE, Fan D, Fidler IJ, Langley RR. Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma. Neoplasia. 2010 Feb; 12(2):173-82. PMID: 20126475.
      View in: PubMed
    46. Rebhun RB, Thamm DH. Multiple distinct malignancies in dogs: 53 cases. J Am Anim Hosp Assoc. 2010 Jan-Feb; 46(1):20-30. PMID: 20045833.
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    47. Rebhun RB, Greenberg MJ, Silver TI. What is your diagnosis? Necrotic lipoma. J Am Vet Med Assoc. 2008 Dec 01; 233(11):1691-2. PMID: 19046024.
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    48. Sasaki T, Nakamura T, Rebhun RB, Cheng H, Hale KS, Tsan RZ, Fidler IJ, Langley RR. Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model. Am J Pathol. 2008 Jul; 173(1):205-16. PMID: 18583324.
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    49. Rebhun RB, Lana SE, Ehrhart EJ, Charles JB, Thamm DH. Comparative analysis of survivin expression in untreated and relapsed canine lymphoma. J Vet Intern Med. 2008 Jul-Aug; 22(4):989-95. PMID: 18647159.
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    50. Rebhun RB, Lazar AJ, Fidler IJ, Gershenwald JE. Impact of sentinel lymphadenectomy on survival in a murine model of melanoma. Clin Exp Metastasis. 2008; 25(3):191-9. PMID: 18264782.
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    51. Rebhun RB, Langley RR, Yokoi K, Fan D, Gershenwald JE, Fidler IJ. Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis. Neoplasia. 2006 Sep; 8(9):747-57. PMID: 16984732.
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    52. Thaker PH, Yokoi K, Jennings NB, Li Y, Rebhun RB, Rousseau DL, Fan D, Sood AK. Inhibition of experimental colon cancer metastasis by the GABA-receptor agonist nembutal. Cancer Biol Ther. 2005 Jul; 4(7):753-8. PMID: 15970706.
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    53. Yokoi K, Thaker PH, Yazici S, Rebhun RR, Nam DH, He J, Kim SJ, Abbruzzese JL, Hamilton SR, Fidler IJ. Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. Cancer Res. 2005 May 01; 65(9):3716-25. PMID: 15867367.
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    54. Langley RR, Fan D, Tsan RZ, Rebhun R, He J, Kim SJ, Fidler IJ. Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells. Cancer Res. 2004 Jun 01; 64(11):3727-30. PMID: 15172974.
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    55. McDonough PL, Rossiter CA, Rebhun RB, Stehman SM, Lein DH, Shin SJ. Prevalence of Escherichia coli O157:H7 from cull dairy cows in New York state and comparison of culture methods used during preharvest food safety investigations. J Clin Microbiol. 2000 Jan; 38(1):318-22. PMID: 10618108.
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