Dennis J Hartigan-OConnor

Title(s)Associate Professor, Medical Microbiology and Immunology
SchoolSchool of Medicine
Address3228 Tupper Hall
CA 95616
Phone530-752-7358
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    Collapse Research 
    Collapse Research Activities and Funding
    Memory-promoting Ad vaccine for long-lived protection against SARS-CoV-2
    NIH R41AI157626Jan 1, 2021 - Jul 31, 2021
    Role: Principal Investigator
    Nucleic acid-based formulation of cytomegalovirus-vectored HIV vaccines
    NIH R41AI150232Apr 7, 2020 - Oct 31, 2021
    Role: Principal Investigator
    Vaccination with self-launching RhCMV/SIV DNA vaccine vectors
    NIH R21AI150553Mar 10, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Effective CMV-based SIV vaccine regimens for newborn infants via IL-10 modulation
    NIH R01AI150554Dec 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools
    NIH U42OD027094Apr 15, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Improved RhCMV/SIV vaccine efficacy via IL-10 pathway modulation
    NIH R01AI143554Sep 24, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of reservoir composition and T cell immunity in HIV rebound kinetics
    NIH P01AI131568Jul 19, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Congenital Zika Syndrome and Postnatal Outcomes in Nonhuman Primates
    NIH R21NS103658Jun 15, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Short and long-term effects of infant microbiota on (RhCMV) SIV vaccine efficacy
    NIH R56AI120737Jul 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Reservoir depletion and anti-retroviral therapy for infant functional cure
    NIH R01AI118451Jun 1, 2015 - May 31, 2020
    Role: Principal Investigator
    Effective lethal agents for CCR5+ expressing cells
    NIH R21AI116230Sep 1, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Regulatory T cell influence on infant and adult immune responses to HIV
    NIH K23AI081540Feb 1, 2009 - Jan 31, 2014
    Role: Principal Investigator
    Impact of T-regulatory cells on SIV disease progression
    NIH F32AI067088Nov 1, 2005 - Oct 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):13036-13041. Deere JD, Chang WLW, Villalobos A, Schmidt KA, Deshpande A, Castillo LD, Fike J, Walter MR, Barry PA, Hartigan-O'Connor DJ. PMID: 31189602; PMCID: PMC6601001.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019 04 04; 4(7). Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S. PMID: 30944245; PMCID: PMC6483647.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsCTClinical Trials
    3. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019 01; 25(1):141-151. Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM. PMID: 30420753; PMCID: PMC6324991.
      View in: PubMed   Mentions: 354     Fields:    Translation:HumansAnimalsCells
    4. Idiopathic Colitis in Rhesus Macaques Is Associated With Dysbiosis, Abundant Enterochromaffin Cells and Altered T-Cell Cytokine Expression. Vet Pathol. 2018 09; 55(5):741-752. Laing ST, Merriam D, Shock BC, Mills S, Spinner A, Reader R, Hartigan-O'Connor DJ. PMID: 29929446.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    5. Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses. J Virol. 2018 07 01; 92(13). Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O'Connor DJ, Dandekar S. PMID: 29669841; PMCID: PMC6002712.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    6. The Effect of Early Limited Formula on Breastfeeding, Readmission, and Intestinal Microbiota: A Randomized Clinical Trial. J Pediatr. 2018 05; 196:84-90.e1. Flaherman VJ, Narayan NR, Hartigan-O'Connor D, Cabana MD, McCulloch CE, Paul IM. PMID: 29550235.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    7. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 2018 03 01; 128(3):1190-1198. Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S. PMID: 29457784; PMCID: PMC5824862.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    8. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. PMID: 29263212; PMCID: PMC5780234.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S81-S92. Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. PMID: 29140110; PMCID: PMC5684667.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S70-S80. Merriam D, Chen C, Méndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ. PMID: 28918646; PMCID: PMC5684671.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge. Sci Transl Med. 2015 Aug 12; 7(300):300ra125. Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM. PMID: 26268312; PMCID: PMC5100009.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Persistent effects of early infant diet and associated microbiota on the juvenile immune system. Gut Microbes. 2015 Jul 04; 6(4):284-9. Narayan NR, Méndez-Lagares G, Ardeshir A, Lu D, Van Rompay KK, Hartigan-O'Connor DJ. PMID: 26177107; PMCID: PMC4615596.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems. Sci Transl Med. 2014 Sep 03; 6(252):252ra120. Ardeshir A, Narayan NR, Méndez-Lagares G, Lu D, Rauch M, Huang Y, Van Rompay KK, Lynch SV, Hartigan-O'Connor DJ. PMID: 25186175; PMCID: PMC4362692.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    14. Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection. J Infect Dis. 2014 May 15; 209(10):1602-12. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. PMID: 24325966; PMCID: PMC3997582.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000; PMCID: PMC3720065.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    16. SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Sci Transl Med. 2012 May 30; 4(136):136ra69. Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM. PMID: 22649090; PMCID: PMC3520607.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    17. Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS. 2011 May; 6(3):221-7. Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S. PMID: 21399494; PMCID: PMC4079838.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    18. The human fetal immune response to hepatitis C virus exposure in utero. J Infect Dis. 2011 Jan 15; 203(2):196-206. Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM. PMID: 21288819; PMCID: PMC3071071.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    19. Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis. 2011 Feb 01; 52(3):409-17. Hartigan-O'Connor DJ, Jacobson MA, Tan QX, Sinclair E, Studies of Ocular Complications of AIDS Research Group. PMID: 21189271; PMCID: PMC3060886.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    20. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007 Oct 29; 204(11):2679-92. Hartigan-O'Connor DJ, Abel K, McCune JM. PMID: 17954571; PMCID: PMC2118477.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    21. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods. 2007 Jan 30; 319(1-2):41-52. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. PMID: 17173927.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    22. Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12979-84. DelloRusso C, Scott JM, Hartigan-O'Connor D, Salvatori G, Barjot C, Robinson AS, Crawford RW, Brooks SV, Chamberlain JS. PMID: 12271128; PMCID: PMC130572.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    23. Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses. J Gene Med. 2002 Sep-Oct; 4(5):480-9. Barjot C, Hartigan-O'Connor D, Salvatori G, Scott JM, Chamberlain JS. PMID: 12221641.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Efficient rescue of gutted adenovirus genomes allows rapid production of concentrated stocks without negative selection. Hum Gene Ther. 2002 Mar 01; 13(4):519-31. Hartigan-O'Connor D, Barjot C, Crawford R, Chamberlain JS. PMID: 11874630.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    25. Generation and growth of gutted adenoviral vectors. Methods Enzymol. 2002; 346:224-46. Hartigan-O'Connor D, Barjot C, Salvatori G, Chamberlain JS. PMID: 11883070.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    26. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res. 2001 Dec 15; 61(24):8794-802. Kirk CJ, Hartigan-O'Connor D, Mulé JJ. PMID: 11751401.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    27. Immune evasion by muscle-specific gene expression in dystrophic muscle. Mol Ther. 2001 Dec; 4(6):525-33. Hartigan-O'Connor D, Kirk CJ, Crawford R, Mulé JJ, Chamberlain JS. PMID: 11735336.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    28. T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy. Cancer Res. 2001 Mar 01; 61(5):2062-70. Kirk CJ, Hartigan-O'Connor D, Nickoloff BJ, Chamberlain JS, Giedlin M, Aukerman L, Mule JJ. PMID: 11280767.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    29. Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. Mol Ther. 2000 Jul; 2(1):16-25. Hauser MA, Robinson A, Hartigan-O'Connor D, Williams-Gregory DA, Buskin JN, Apone S, Kirk CJ, Hardy S, Hauschka SD, Chamberlain JS. PMID: 10899824.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    30. Replication of lengthened Moloney murine leukemia virus genomes is impaired at multiple stages. J Virol. 2000 Mar; 74(6):2694-702. Shin NH, Hartigan-O'Connor D, Pfeiffer JK, Telesnitsky A. PMID: 10684285; PMCID: PMC111759.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    31. Developments in gene therapy for muscular dystrophy. Microsc Res Tech. 2000 Feb 1-15; 48(3-4):223-38. Hartigan-O'Connor D, Chamberlain JS. PMID: 10679969.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase. J Virol. 1999 Sep; 73(9):7835-41. Hartigan-O'Connor D, Amalfitano A, Chamberlain JS. PMID: 10438876; PMCID: PMC104313.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. PMID: 10217145.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    34. Progress toward gene therapy of Duchenne muscular dystrophy. Semin Neurol. 1999; 19(3):323-32. Hartigan-O'Connor D, Chamberlain JS. PMID: 12194388.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    35. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, Rubenstein JL, German MS. PMID: 9584121.
      View in: PubMed   Mentions: 223     Fields:    Translation:Animals
    36. The cDNA sequence of murine Nkx-2.2. Gene. 1996 Feb 12; 168(2):271-2. Hartigan DJ, Rubenstein JL. PMID: 8654958.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec; 121(12):3923-33. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL. PMID: 8575293.
      View in: PubMed   Mentions: 161     Fields:    Translation:Animals
    38. Basic fibroblast growth factor increases the number of excitatory neurons containing glutamate in the cerebral cortex. Cereb Cortex. 1995 Jan-Feb; 5(1):64-78. Vaccarino FM, Schwartz ML, Hartigan D, Leckman JF. PMID: 7719131.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Enhancement of antineoplastic activity of 5-fluorouracil in mice bearing colon 38 tumor by (6R)5,10-dideazatetrahydrofolic acid. Biochem Pharmacol. 1994 Jun 01; 47(11):1981-8. Pizzorno G, Davis SJ, Hartigan DJ, Russello O. PMID: 7516657.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    40. Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Res Mol Brain Res. 1993 Jul; 19(1-2):76-82. Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ. PMID: 8103187.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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