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Dennis Hartigan-O'Connor, MD; PhD

Title(s)Associate Professor, Medical Microbiology And Immunology
SchoolUniversity of California, Davis
Phone530-752-7358
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Deere JD, Chang WLW, Villalobos A, Schmidt KA, Deshpande A, Castillo LD, Fike J, Walter MR, Barry PA, Hartigan-O'Connor DJ. Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity. Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26):13036-13041. PMID: 31189602.
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    2. Jiang G, Maverakis E, Cheng MY, Elsheikh MM, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O'Connor DJ, Thompson GR, Estes JD, Wong JK, Dandekar S. Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019 04 04; 4(7). PMID: 30944245.
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    3. Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019 01; 25(1):141-151. PMID: 30420753.
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    4. Laing ST, Merriam D, Shock BC, Mills S, Spinner A, Reader R, Hartigan-O'Connor DJ. Idiopathic Colitis in Rhesus Macaques Is Associated With Dysbiosis, Abundant Enterochromaffin Cells and Altered T-Cell Cytokine Expression. Vet Pathol. 2018 09; 55(5):741-752. PMID: 29929446.
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    5. Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O'Connor DJ, Dandekar S. Subclinical Cytomegalovirus Infection Is Associated with Altered Host Immunity, Gut Microbiota, and Vaccine Responses. J Virol. 2018 07 01; 92(13). PMID: 29669841.
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    6. Flaherman VJ, Narayan NR, Hartigan-O'Connor D, Cabana MD, McCulloch CE, Paul IM. The Effect of Early Limited Formula on Breastfeeding, Readmission, and Intestinal Microbiota: A Randomized Clinical Trial. J Pediatr. 2018 05; 196:84-90.e1. PMID: 29550235.
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    7. Jiang G, Nguyen D, Archin NM, Yukl SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR, Hartigan-O'Connor DJ, Margolis DM, Wong JK, Dandekar S. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest. 2018 03 01; 128(3):1190-1198. PMID: 29457784.
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    8. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 02 01; 200(3):1124-1132. PMID: 29263212.
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    9. Merriam D, Chen C, Méndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ. Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S70-S80. PMID: 28918646.
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    10. Méndez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8+ T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S81-S92. PMID: 29140110.
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    11. Baker CA, Swainson L, Lin DL, Wong S, Hartigan-O'Connor DJ, Lifson JD, Tarantal AF, McCune JM. Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge. Sci Transl Med. 2015 Aug 12; 7(300):300ra125. PMID: 26268312.
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    12. Narayan NR, Méndez-Lagares G, Ardeshir A, Lu D, Van Rompay KK, Hartigan-O'Connor DJ. Persistent effects of early infant diet and associated microbiota on the juvenile immune system. Gut Microbes. 2015 Jul 04; 6(4):284-9. PMID: 26177107.
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    13. Ardeshir A, Narayan NR, Méndez-Lagares G, Lu D, Rauch M, Huang Y, Van Rompay KK, Lynch SV, Hartigan-O'Connor DJ. Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems. Sci Transl Med. 2014 Sep 03; 6(252):252ra120. PMID: 25186175.
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    14. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. Monocyte activation by interferon a is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection. J Infect Dis. 2014 May 15; 209(10):1602-12. PMID: 24325966.
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    15. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. PMID: 23657000.
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    16. Hartigan-O'Connor DJ, Abel K, Van Rompay KK, Kanwar B, McCune JM. SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Sci Transl Med. 2012 May 30; 4(136):136ra69. PMID: 22649090.
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    17. Hartigan-O'Connor DJ, Hirao LA, McCune JM, Dandekar S. Th17 cells and regulatory T cells in elite control over HIV and SIV. Curr Opin HIV AIDS. 2011 May; 6(3):221-7. PMID: 21399494.
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    18. Babik JM, Cohan D, Monto A, Hartigan-O'Connor DJ, McCune JM. The human fetal immune response to hepatitis C virus exposure in utero. J Infect Dis. 2011 Jan 15; 203(2):196-206. PMID: 21288819.
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    19. Hartigan-O'Connor DJ, Jacobson MA, Tan QX, Sinclair E. Development of cytomegalovirus (CMV) immune recovery uveitis is associated with Th17 cell depletion and poor systemic CMV-specific T cell responses. Clin Infect Dis. 2011 Feb 01; 52(3):409-17. PMID: 21189271.
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    20. Hartigan-O'Connor DJ, Abel K, McCune JM. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007 Oct 29; 204(11):2679-92. PMID: 17954571.
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    21. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods. 2007 Jan 30; 319(1-2):41-52. PMID: 17173927.
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    22. DelloRusso C, Scott JM, Hartigan-O'Connor D, Salvatori G, Barjot C, Robinson AS, Crawford RW, Brooks SV, Chamberlain JS. Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12979-84. PMID: 12271128.
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    23. Barjot C, Hartigan-O'Connor D, Salvatori G, Scott JM, Chamberlain JS. Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses. J Gene Med. 2002 Sep-Oct; 4(5):480-9. PMID: 12221641.
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    24. Hartigan-O'Connor D, Barjot C, Crawford R, Chamberlain JS. Efficient rescue of gutted adenovirus genomes allows rapid production of concentrated stocks without negative selection. Hum Gene Ther. 2002 Mar 01; 13(4):519-31. PMID: 11874630.
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    25. Hartigan-O'Connor D, Barjot C, Salvatori G, Chamberlain JS. Generation and growth of gutted adenoviral vectors. Methods Enzymol. 2002; 346:224-46. PMID: 11883070.
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    26. Kirk CJ, Hartigan-O'Connor D, Mulé JJ. The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally. Cancer Res. 2001 Dec 15; 61(24):8794-802. PMID: 11751401.
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    27. Hartigan-O'Connor D, Kirk CJ, Crawford R, Mulé JJ, Chamberlain JS. Immune evasion by muscle-specific gene expression in dystrophic muscle. Mol Ther. 2001 Dec; 4(6):525-33. PMID: 11735336.
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    28. Kirk CJ, Hartigan-O'Connor D, Nickoloff BJ, Chamberlain JS, Giedlin M, Aukerman L, Mule JJ. T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy. Cancer Res. 2001 Mar 01; 61(5):2062-70. PMID: 11280767.
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    29. Hauser MA, Robinson A, Hartigan-O'Connor D, Williams-Gregory DA, Buskin JN, Apone S, Kirk CJ, Hardy S, Hauschka SD, Chamberlain JS. Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. Mol Ther. 2000 Jul; 2(1):16-25. PMID: 10899824.
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    30. Shin NH, Hartigan-O'Connor D, Pfeiffer JK, Telesnitsky A. Replication of lengthened Moloney murine leukemia virus genomes is impaired at multiple stages. J Virol. 2000 Mar; 74(6):2694-702. PMID: 10684285.
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    31. Hartigan-O'Connor D, Chamberlain JS. Developments in gene therapy for muscular dystrophy. Microsc Res Tech. 2000 Feb 1-15; 48(3-4):223-38. PMID: 10679969.
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    32. Hartigan-O'Connor D, Amalfitano A, Chamberlain JS. Improved production of gutted adenovirus in cells expressing adenovirus preterminal protein and DNA polymerase. J Virol. 1999 Sep; 73(9):7835-41. PMID: 10438876.
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    33. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. PMID: 10217145.
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    34. Hartigan-O'Connor D, Chamberlain JS. Progress toward gene therapy of Duchenne muscular dystrophy. Semin Neurol. 1999; 19(3):323-32. PMID: 12194388.
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    35. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. PMID: 9584121.
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    36. Hartigan DJ, Rubenstein JL. The cDNA sequence of murine Nkx-2.2. Gene. 1996 Feb 12; 168(2):271-2. PMID: 8654958.
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    37. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JL. Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec; 121(12):3923-33. PMID: 8575293.
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    38. Vaccarino FM, Schwartz ML, Hartigan D, Leckman JF. Basic fibroblast growth factor increases the number of excitatory neurons containing glutamate in the cerebral cortex. Cereb Cortex. 1995 Jan-Feb; 5(1):64-78. PMID: 7719131.
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    39. Pizzorno G, Davis SJ, Hartigan DJ, Russello O. Enhancement of antineoplastic activity of 5-fluorouracil in mice bearing colon 38 tumor by (6R)5,10-dideazatetrahydrofolic acid. Biochem Pharmacol. 1994 Jun 01; 47(11):1981-8. PMID: 7516657.
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    40. Vaccarino FM, Hayward MD, Le HN, Hartigan DJ, Duman RS, Nestler EJ. Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Res Mol Brain Res. 1993 Jul; 19(1-2):76-82. PMID: 8103187.
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