Angela Franciska Haczku

Title(s)Professor, Pulmonary, Critical Care, and Sleep Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zeki AA, Flayer CH, Haczku A. A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries. J Allergy Clin Immunol. 2018 Dec 05. PMID: 30529450.
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    2. Yousefi S, Sharma SK, Stojkov D, Germic N, Aeschlimann S, Ge MQ, Flayer CH, Larson ED, Redai IG, Zhang S, Koziol-White CJ, Karikó K, Simon HU, Haczku A. Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation. J Leukoc Biol. 2018 Jul; 104(1):205-214. PMID: 29733456.
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    3. Shen X, Pasha MA, Hidde K, Khan A, Liang M, Guan W, Ding Y, Haczku A, Yang Q. Group 2 innate lymphoid cells promote airway hyperresponsiveness through production of VEGFA. J Allergy Clin Immunol. 2018 May; 141(5):1929-1931.e4. PMID: 29382598.
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    4. Flayer CH, Larson ED, Haczku A. Breaking Steroid Resistance: Effect of Vitamin D on IL-23. Am J Respir Cell Mol Biol. 2017 09; 57(3):267-269. PMID: 28862504.
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    5. Nguyen DV, Linderholm A, Haczku A, Kenyon N. Glucagon-like peptide 1: A potential anti-inflammatory pathway in obesity-related asthma. Pharmacol Ther. 2017 Dec; 180:139-143. PMID: 28648831.
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    6. Schivo M, Albertson TE, Haczku A, Kenyon NJ, Zeki AA, Kuhn BT, Louie S, Avdalovic MV. Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease. J Investig Med. 2017 08; 65(6):953-963. PMID: 28258130.
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    7. Nguyen DV, Linderholm A, Haczku A, Kenyon N. Obesity-related, metabolic asthma: a new role for glucagon-like peptide 1 agonists. Lancet Respir Med. 2017 03; 5(3):162-164. PMID: 28266322.
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    8. Sklarz T, Guan P, Gohil M, Cotton RM, Ge MQ, Haczku A, Das R, Jordan MS. mTORC2 regulates multiple aspects of NKT-cell development and function. Eur J Immunol. 2017 03; 47(3):516-526. PMID: 28078715.
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    9. Zhang K, Xu X, Pasha MA, Siebel CW, Costello A, Haczku A, MacNamara K, Liang T, Zhu J, Bhandoola A, Maillard I, Yang Q. Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells. J Immunol. 2017 03 01; 198(5):1798-1803. PMID: 28115527.
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    10. Chua YL, Liong KH, Huang CH, Wong HS, Zhou Q, Ler SS, Tang Y, Low CP, Koh HY, Kuo IC, Zhang Y, Wong WS, Peh HY, Lim HY, Ge MQ, Haczku A, Angeli V, MacAry PA, Chua KY, Kemeny DM. Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism. J Immunol. 2016 11 15; 197(10):3771-3781. PMID: 27733553.
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    11. Ge MQ, Kokalari B, Flayer CH, Killingbeck SS, Redai IG, MacFarlane AW, Hwang JW, Kolupoti A, Kemeny DM, Campbell KS, Haczku A. Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure. J Immunol. 2016 Apr 01; 196(7):3212. PMID: 26994305.
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    12. Ge MQ, Kokalari B, Flayer CH, Killingbeck SS, Redai IG, MacFarlane AW, Hwang JW, Kolupoti A, Kemeny MD, Campbell KS, Haczku A. Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure. J Immunol. 2016 Jan 15; 196(2):553-7. PMID: 26673133.
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    13. Yang Q, Ge MQ, Kokalari B, Redai IG, Wang X, Kemeny DM, Bhandoola A, Haczku A. Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 2016 Feb; 137(2):571-8. PMID: 26282284.
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    14. Wang Y, Miwa T, Ducka-Kokalari B, Redai IG, Sato S, Gullipalli D, Zangrilli JG, Haczku A, Song WC. Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. J Immunol. 2015 Aug 01; 195(3):1171-81. PMID: 26116506; PMCID: PMC4506880.
    15. Myint M, Limberis MP, Bell P, Somanathan S, Haczku A, Wilson JM, Diamond SL. In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection. Hum Gene Ther. 2014 Nov; 25(11):966-76. PMID: 25144316; PMCID: PMC4235593.
    16. Adam VS, Crosariol M, Kumar S, Ge MQ, Czack SE, Roy S, Haczku A, Tretiakova A, Wilson JM, Limberis MP. Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus. Clin Vaccine Immunol. 2014 Nov; 21(11):1528-33. PMID: 25209558; PMCID: PMC4248762.
    17. Kim WK, Jain D, Sánchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA, Frieman MB, López CB. Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):437-48. PMID: 24417465; PMCID: PMC3977719.
    18. Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013 Apr 18; 38(4):694-704. PMID: 23601684; PMCID: PMC4029843.
    19. Jordan M, Haczku A. Autoreactive bronchus-associated lymphoid tissue in interstitial lung disease: friend or foe? Am J Respir Cell Mol Biol. 2013 Apr; 48(4):397-8. PMID: 23544886.
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    20. Jiang Z, Fehrenbach ML, Ravaioli G, Kokalari B, Redai IG, Sheardown SA, Wilson S, Macphee C, Haczku A. The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12; 13:100. PMID: 23140447; PMCID: PMC3546878.
    21. Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM). Sci Transl Med. 2012 Oct 03; 4(154):154ra134. PMID: 23035046; PMCID: PMC3684391.
    22. Haczku A. The dendritic cell niche in chronic obstructive pulmonary disease. Respir Res. 2012 Sep 19; 13:80. PMID: 22992180; PMCID: PMC3507810.
    23. Sziksz E, Vannay A, Haczku A. Galectin-9: a suppressor of food allergy? Allergy. 2012 Mar; 67(3):293-5. PMID: 22324313; PMCID: PMC3362590.
    24. Anderson AL, Zheng Y, Song D, Larosa D, Van Rooijen N, Kierstein G, Kierstein S, Haczku A, Levinson AI. The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins. Inflamm Res. 2012 Feb; 61(2):161-9. PMID: 22249932; PMCID: PMC3279619.
    25. Orgeig S, Hiemstra PS, Veldhuizen EJ, Casals C, Clark HW, Haczku A, Knudsen L, Possmayer F. Recent advances in alveolar biology: evolution and function of alveolar proteins. Respir Physiol Neurobiol. 2010 Aug 31; 173 Suppl:S43-54. PMID: 20433956; PMCID: PMC4097100.
    26. Wang M, Cooper PR, Jiang M, Zhao H, Hui Y, Yao Y, Tate JC, Damera G, Lawson JA, Jester WF, Haczku A, Panettieri RA, FitzGerald GA. Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. J Pharmacol Exp Ther. 2010 Jul; 334(1):63-8. PMID: 20371706; PMCID: PMC2912039.
    27. Damera G, Jester WF, Jiang M, Zhao H, Fogle HW, Mittelman M, Haczku A, Murphy E, Parikh I, Panettieri RA. Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation. Exp Lung Res. 2010 Mar; 36(2):75-84. PMID: 20205598.
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    28. Haczku A, Panettieri RA. Social stress and asthma: the role of corticosteroid insensitivity. J Allergy Clin Immunol. 2010 Mar; 125(3):550-8. PMID: 20153032; PMCID: PMC2839059.
    29. Bágyi K, Haczku A, Márton I, Szabó J, Gáspár A, Andrási M, Varga I, Tóth J, Klekner A. Role of pathogenic oral flora in postoperative pneumonia following brain surgery. BMC Infect Dis. 2009 Jun 29; 9:104. PMID: 19563632; PMCID: PMC2709628.
    30. Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri RA, Haczku A. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. J Immunol. 2009 Jun 15; 182(12):7888-96. PMID: 19494313; PMCID: PMC2767120.
    31. Haczku A. Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation. J Allergy Clin Immunol. 2008 Nov; 122(5):861-79; quiz 880-1. PMID: 19000577; PMCID: PMC4097097.
    32. Hortobágyi L, Kierstein S, Krytska K, Zhu X, Das AM, Poulain F, Haczku A. Surfactant protein D inhibits TNF-alpha production by macrophages and dendritic cells in mice. J Allergy Clin Immunol. 2008 Sep; 122(3):521-528. PMID: 18554706; PMCID: PMC4024109.
    33. Alexis NE, Lay JC, Haczku A, Gong H, Linn W, Hazucha MJ, Harris B, Tal-Singer R, Peden DB. Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers. Environ Health Perspect. 2008 Jun; 116(6):799-805. PMID: 18560537; PMCID: PMC2430237.
    34. Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, Panettieri RA, Haczku A, Amrani Y. Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness. Immunobiology. 2008; 213(6):499-509. PMID: 18514752; PMCID: PMC2587232.
    35. Sims MW, Tal-Singer RM, Kierstein S, Musani AI, Beers MF, Panettieri RA, Haczku A. Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res. 2008 Jan 28; 9:13. PMID: 18226251; PMCID: PMC2249580.
    36. McVay LD, Keilbaugh SA, Wong TM, Kierstein S, Shin ME, Lehrke M, Lefterova MI, Shifflett DE, Barnes SL, Cominelli F, Cohn SM, Hecht G, Lazar MA, Haczku A, Wu GD. Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. J Clin Invest. 2006 Nov; 116(11):2914-23. PMID: 17024245; PMCID: PMC1590268.
    37. Haczku A, Cao Y, Vass G, Kierstein S, Nath P, Atochina-Vasserman EN, Scanlon ST, Li L, Griswold DE, Chung KF, Poulain FR, Hawgood S, Beers MF, Crouch EC. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol. 2006 Mar 15; 176(6):3557-65. PMID: 16517724.
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    38. Haczku A, Emami K, Fischer MC, Kadlecek S, Ishii M, Panettieri RA, Rizi RR. Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results. Acad Radiol. 2005 Nov; 12(11):1362-70. PMID: 16253848.
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    39. Haczku A. Role and regulation of lung collectins in allergic airway sensitization. Pharmacol Ther. 2006 Apr; 110(1):14-34. PMID: 16226313.
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    40. Scanlon ST, Milovanova T, Kierstein S, Cao Y, Atochina EN, Tomer Y, Russo SJ, Beers MF, Haczku A. Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses. Respir Res. 2005 Aug 24; 6:97. PMID: 16120217; PMCID: PMC1208955.
    41. Atochina EN, Beck JM, Preston AM, Haczku A, Tomer Y, Scanlon ST, Fusaro T, Casey J, Hawgood S, Gow AJ, Beers MF. Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species. Infect Immun. 2004 Oct; 72(10):6002-11. PMID: 15385504; PMCID: PMC517574.
    42. Yang G, Haczku A, Chen H, Martin V, Galczenski H, Tomer Y, Van Besien CR, Evans JF, Panettieri RA, Funk CD, Van Beisen CR. Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5):L992-1001. PMID: 15064240.
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    43. Atochina EN, Gow AJ, Beck JM, Haczku A, Inch A, Kadire H, Tomer Y, Davis C, Preston AM, Poulain F, Hawgood S, Beers MF. Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice. J Infect Dis. 2004 Apr 15; 189(8):1528-39. PMID: 15073692.
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    44. Cao Y, Tao JQ, Bates SR, Beers MF, Haczku A. IL-4 induces production of the lung collectin surfactant protein-D. J Allergy Clin Immunol. 2004 Mar; 113(3):439-44. PMID: 15007344.
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    45. Atochina EN, Beers MF, Tomer Y, Scanlon ST, Russo SJ, Panettieri RA, Haczku A. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Respir Res. 2003; 4:15. PMID: 14748931; PMCID: PMC314399.
    46. Rha YH, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. J Immunol. 2002 Nov 01; 169(9):5300-7. PMID: 12391250.
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    47. Haczku A, Atochina EN, Tomer Y, Cao Y, Campbell C, Scanlon ST, Russo SJ, Enhorning G, Beers MF. The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L755-65. PMID: 12225952.
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