Stefan Rothenburg

Title(s)Associate Professor, Medical Microbiology and Immunology
SchoolSchool of Medicine
AddressRm 3141 Tupper Hall
CA 95616
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    Molecular mechanisms and ramifications of horizontal gene transfer into poxviruses
    NIH R01AI146915Feb 18, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Importance of Species-Specific Interactions of PKR with Poxvirus Inhibitors for Virus Replication and Host Range
    NIH R01AI114851Jun 24, 2015 - May 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Molecular basis for the host range function of the poxvirus PKR inhibitor E3. bioRxiv. 2024 May 16. Haller SL, Park C, Bruneau RC, Megawati D, Zhang C, Vipat S, Peng C, Senkevich TG, Brennan G, Tazi L, Rothenburg S. PMID: 38798513; PMCID: PMC11118487.
      View in: PubMed   Mentions:
    2. Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats. Biomolecules. 2023 02 08; 13(2). Bruneau RC, Tazi L, Rothenburg S. PMID: 36830694; PMCID: PMC9953750.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. Molecular Mechanisms of Poxvirus Evolution. mBio. 2023 02 28; 14(1):e0152622. Brennan G, Stoian AMM, Yu H, Rahman MJ, Banerjee S, Stroup JN, Park C, Tazi L, Rothenburg S. PMID: 36515529; PMCID: PMC9973261.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    4. Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions. Sci Adv. 2022 Nov 25; 8(47):eadd7540. Jacquet S, Culbertson M, Zhang C, El Filali A, De La Myre Mory C, Pons JB, Filippi-Codaccioni O, Lauterbur ME, Ngoubangoye B, Duhayer J, Verez C, Park C, Dahoui C, Carey CM, Brennan G, Enard D, Cimarelli A, Rothenburg S, Elde NC, Pontier D, Etienne L. PMID: 36417524; PMCID: PMC9683710.
      View in: PubMed   Mentions: 6     Fields:    
    5. Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways. Virus Evol. 2022; 8(2):veac105. Banerjee S, Smith C, Geballe AP, Rothenburg S, Kitzman JO, Brennan G. PMID: 36483110; PMCID: PMC9724558.
      View in: PubMed   Mentions:
    6. Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways. bioRxiv. 2022 Oct 06. Banerjee S, Smith C, Geballe A, Rothenburg S, Kitzman JO, Brennan G. PMID: 35702158; PMCID: PMC9196108.
      View in: PubMed   Mentions: 1  
    7. Poxviruses capture host genes by LINE-1 retrotransposition. Elife. 2022 09 07; 11. Fixsen SM, Cone KR, Goldstein SA, Sasani TA, Quinlan AR, Rothenburg S, Elde NC. PMID: 36069526; PMCID: PMC9578705.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    8. LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses. Elife. 2022 09 07; 11. Rahman MJ, Haller SL, Stoian AMM, Li J, Brennan G, Rothenburg S. PMID: 36069678; PMCID: PMC9578709.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Monkeypox emergency: Urgent questions and perspectives. Cell. 2022 09 01; 185(18):3279-3281. Rothenburg S, Yang Z, Beard P, Sawyer SL, Titanji B, Gonsalves G, Kindrachuk J. PMID: 35998628; PMCID: PMC9395144.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    10. Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R. Viruses. 2022 07 19; 14(7). Rahman MJ, Tazi L, Haller SL, Rothenburg S. PMID: 35891544; PMCID: PMC9318007.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-κB pathway. Proc Natl Acad Sci U S A. 2022 05 17; 119(20):e2115354119. Yu H, Peng C, Zhang C, Stoian AMM, Tazi L, Brennan G, Rothenburg S. PMID: 35549551; PMCID: PMC9171774.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion. Biomedicines. 2021 Jul 01; 9(7). Yu H, Bruneau RC, Brennan G, Rothenburg S. PMID: 34356829; PMCID: PMC8301327.
      View in: PubMed   Mentions: 33  
    13. SARS-CoV-2 detection and genomic sequencing from hospital surface samples collected at UC Davis. PLoS One. 2021; 16(6):e0253578. Coil DA, Albertson T, Banerjee S, Brennan G, Campbell AJ, Cohen SH, Dandekar S, Díaz-Muñoz SL, Eisen JA, Goldstein T, Jose IR, Juarez M, Robinson BA, Rothenburg S, Sandrock C, Stoian AMM, Tompkins DG, Tremeau-Bravard A, Haczku A. PMID: 34166421; PMCID: PMC8224861.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR. PLoS Pathog. 2021 01; 17(1):e1009183. Park C, Peng C, Rahman MJ, Haller SL, Tazi L, Brennan G, Rothenburg S. PMID: 33444388; PMCID: PMC7840043.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Rapid, Seamless Generation of Recombinant Poxviruses using Host Range and Visual Selection. J Vis Exp. 2020 05 24; (159). Vipat S, Brennan G, Park C, Haller SL, Rothenburg S. PMID: 32510495; PMCID: PMC8051324.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Species-Specific Host-Virus Interactions: Implications for Viral Host Range and Virulence. Trends Microbiol. 2020 01; 28(1):46-56. Rothenburg S, Brennan G. PMID: 31597598; PMCID: PMC6925338.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    17. Species-specific inhibition of antiviral protein kinase R by capripoxviruses and vaccinia virus. Ann N Y Acad Sci. 2019 02; 1438(1):18-29. Park C, Peng C, Brennan G, Rothenburg S. PMID: 30644558; PMCID: PMC7989821.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. AC dielectrophoretic manipulation and electroporation of vaccinia virus using carbon nanoelectrode arrays. Electrophoresis. 2017 06; 38(11):1515-1525. Madiyar FR, Haller SL, Farooq O, Rothenburg S, Culbertson C, Li J. PMID: 28211116.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    19. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Res. 2016 Oct 14; 44(18):8704-8713. Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. PMID: 27325740; PMCID: PMC5062967.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    20. Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3855-60. Peng C, Haller SL, Rahman MM, McFadden G, Rothenburg S. PMID: 26903626; PMCID: PMC4833222.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. Evolution of eIF2a Kinases: Adapting Translational Control to Diverse Stresses. . 2016 Jan 1; 235-260. Rothenburg RS, Georgiadis GM, Wek WR. .
      View in: Publisher Site   Mentions:
    22. Ectopic expression of vaccinia virus E3 and K3 cannot rescue ectromelia virus replication in rabbit RK13 cells. PLoS One. 2015; 10(3):e0119189. Hand ES, Haller SL, Peng C, Rothenburg S, Hersperger AR. PMID: 25734776; PMCID: PMC4348479.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. PLoS Genet. 2015 Feb; 11(2):e1004991. Lageix S, Zhang J, Rothenburg S, Hinnebusch AG. PMID: 25695491; PMCID: PMC4335047.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    24. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression. Nucleic Acids Res. 2014; 42(16):10321-30. Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. PMID: 25147208; PMCID: PMC4176352.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cells. PLoS Genet. 2014 May; 10(5):e1004326. Lageix S, Rothenburg S, Dever TE, Hinnebusch AG. PMID: 24811037; PMCID: PMC4014428.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. Adaptive gene amplification as an intermediate step in the expansion of virus host range. PLoS Pathog. 2014 Mar; 10(3):e1004002. Brennan G, Kitzman JO, Rothenburg S, Shendure J, Geballe AP. PMID: 24626510; PMCID: PMC3953438.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    27. Poxviruses and the evolution of host range and virulence. Infect Genet Evol. 2014 Jan; 21:15-40. Haller SL, Peng C, McFadden G, Rothenburg S. PMID: 24161410; PMCID: PMC3945082.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    28. Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. PLoS Pathog. 2013; 9(7):e1003465. Rahman MM, Liu J, Chan WM, Rothenburg S, McFadden G. PMID: 23853588; PMCID: PMC3701710.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    29. A survey of host range genes in poxvirus genomes. Infect Genet Evol. 2013 Mar; 14:406-25. Bratke KA, McLysaght A, Rothenburg S. PMID: 23268114; PMCID: PMC4080715.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    30. The poxvirus C7L host range factor superfamily. Curr Opin Virol. 2012 Dec; 2(6):764-72. Liu J, Rothenburg S, McFadden G. PMID: 23103013; PMCID: PMC3508084.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. BMC Microbiol. 2011 Mar 18; 11:56. Rothenburg S, Chinchar VG, Dever TE. PMID: 21418572; PMCID: PMC3068933.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo. EMBO J. 2011 Jan 19; 30(2):302-16. Park EH, Walker SE, Lee JM, Rothenburg S, Lorsch JR, Hinnebusch AG. PMID: 21139564; PMCID: PMC3025458.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    33. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J Virol. 2010 Jan; 84(1):585-98. DeFilippis VR, Alvarado D, Sali T, Rothenburg S, Früh K. PMID: 19846511; PMCID: PMC2798427.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    34. Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol. 2009 Sep 25; 392(3):701-22. Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG. PMID: 19616556; PMCID: PMC2937263.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    35. Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. Nat Struct Mol Biol. 2009 Jan; 16(1):63-70. Rothenburg S, Seo EJ, Gibbs JS, Dever TE, Dittmar K. PMID: 19043413; PMCID: PMC3142916.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    36. IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol. 2008 Dec; 10(12):2579-88. Lippmann J, Rothenburg S, Deigendesch N, Eitel J, Meixenberger K, van Laak V, Slevogt H, N'guessan PD, Hippenstiel S, Chakraborty T, Flieger A, Suttorp N, Opitz B. PMID: 18771559.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    37. Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. BMC Biol. 2008 Mar 03; 6:12. Rothenburg S, Deigendesch N, Dey M, Dever TE, Tazi L. PMID: 18312693; PMCID: PMC2291453.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    38. Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo. FASEB J. 2007 Nov; 21(13):3490-8. Koch-Nolte F, Reyelt J, Schössow B, Schwarz N, Scheuplein F, Rothenburg S, Haag F, Alzogaray V, Cauerhff A, Goldbaum FA. PMID: 17575259.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    39. ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains. Nucleic Acids Res. 2006; 34(18):5007-20. Deigendesch N, Koch-Nolte F, Rothenburg S. PMID: 16990255; PMCID: PMC1636418.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    40. Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats. Immunogenetics. 2005 Nov; 57(10):739-49. Rothenburg S, Haag F, Koch-Nolte F, Carter C, Graham M, Butcher GW. PMID: 16195877.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    41. A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1602-7. Rothenburg S, Deigendesch N, Dittmar K, Koch-Nolte F, Haag F, Lowenhaupt K, Rich A. PMID: 15659550; PMCID: PMC547857.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    42. Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus. J Mol Evol. 2002 Sep; 55(3):251-9. Rothenburg S, Eiben M, Koch-Nolte F, Haag F. PMID: 12187378.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    43. Complex regulation of the human gene for the Z-DNA binding protein DLM-1. Nucleic Acids Res. 2002 Feb 15; 30(4):993-1000. Rothenburg S, Schwartz T, Koch-Nolte F, Haag F. PMID: 11842111; PMCID: PMC100341.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    44. DNA methylation and Z-DNA formation as mediators of quantitative differences in the expression of alleles. Immunol Rev. 2001 Dec; 184:286-98. Rothenburg S, Koch-Nolte F, Haag F. PMID: 12086319.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    45. A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):8985-90. Rothenburg S, Koch-Nolte F, Rich A, Haag F. PMID: 11447254; PMCID: PMC55360.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    46. DNA methylation contributes to tissue- and allele-specific expression of the T-cell differentiation marker RT6. Immunogenetics. 2001; 52(3-4):231-41. Rothenburg S, Koch-Nolte F, Thiele HG, Haag F. PMID: 11220625.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. Expression of the T-cell differentiation antigen RT6.2 in T-cell lines is correlated with hypomethylation of the RT6 promoter. Transplant Proc. 1999 May; 31(3):1624-5. Rothenburg S, Koch-Nolte F, Thiele HG, Haag F. PMID: 10331027.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    48. Evidence that allelic variations in the main RT6 promoter modulate transcriptional activity. Transplant Proc. 1999 May; 31(3):1626-8. Rothenburg S, Koch-Nolte F, Thiele HG, Haag F. PMID: 10331028.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Mutation of a putative TATA motif does not affect transcription by the promoter of the rat T cell differentiation marker RT6. Transplant Proc. 1999 May; 31(3):1629-30. Fang J, Rothenburg S, Koch-Nolte F, Thiele HG, Haag F. PMID: 10331029.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    50. Polymorphic microsatellite within the main promoter of the rat T cell differentiation antigen RT6 on chromosome 1. Transplant Proc. 1997 May; 29(3):1703-4. Haag F, Rothenburg S, Koch-Nolte F, Thiele HG. PMID: 9142239.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. Expression of the RT6 mono(ADP-ribosyl)transferases is regulated by two promoter regions. Adv Exp Med Biol. 1997; 419:265-70. Kuhlenbäumer G, Rothenburg S, Matthes M, Hollmann C, Wingender E, Thiele HG, Koch-Nolte F, Haag F. PMID: 9193664.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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