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Nicholas J. Kenyon

TitleProfessor
InstitutionUniversity of California Davis
DepartmentPulmonary, Critical Care, and Sleep Medicine
AddressPSSB/UCDMC
CA 95817
Phone530-754-6935
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    Collapse Research 
    Collapse Research Activities and Funding
    NRSA Training Core
    NIH/NCATS TL1TR001861Jul 1, 2016 - May 31, 2021
    Role: Principal Investigator
    A wearable monitor for pediatric asthma: Developing environmental and breath sensors linked to spirometry
    NIH/NIBIB U01EB022003Sep 30, 2015 - Sep 29, 2019
    Role: Co-Principal Investigator
    L-arginine as a therapy in severe asthma
    NIH/NHLBI R01HL105573Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator
    PROTECTIVE ROLE FOR NITRIC OXIDE IN AIRWAY INFLAMMATION
    NIH/NHLBI K08HL076415Sep 26, 2005 - Aug 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zamuruyev KO, Schmidt AJ, Borras E, McCartney MM, Schivo M, Kenyon NJ, Delplanque JP, Davis CE. Power efficient, self-cleaning hydrophilic condenser surface for portable exhaled breath condensate (EBC) metabolomic sampling. J Breath Res. 2018 May 17. PMID: 29771240.
      View in: PubMed
    2. Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA. Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. J Immunol. 2018 Apr 27. PMID: 29703864.
      View in: PubMed
    3. Showalter MR, Nonnecke EB, Linderholm AL, Cajka T, Sa MR, Lönnerdal B, Kenyon NJ, Fiehn O. Obesogenic diets alter metabolism in mice. PLoS One. 2018; 13(1):e0190632. PMID: 29324762.
      View in: PubMed
    4. Zamuruyev KO, Borras E, Pettit DR, Aksenov AA, Simmons JD, Weimer BC, Schivo M, Kenyon NJ, Delplanque JP, Davis CE. Effect of temperature control on the metabolite content in exhaled breath condensate. Anal Chim Acta. 2018 May 02; 1006:49-60. PMID: 30016264.
      View in: PubMed
    5. Cagle LA, Franzi LM, Linderholm AL, Last JA, Adams JY, Harper RW, Kenyon NJ. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model. PLoS One. 2017; 12(11):e0187419. PMID: 29112971.
      View in: PubMed
    6. Tan LD, Kenyon N, Yoneda KY, Louie S. Bronchial thermoplasty: implementing best practice in the era of cost containment. J Asthma Allergy. 2017; 10:225-230. PMID: 28794646.
      View in: PubMed
    7. Aksenov AA, Zamuruyev KO, Pasamontes A, Brown JF, Schivo M, Foutouhi S, Weimer BC, Kenyon NJ, Davis CE. Analytical methodologies for broad metabolite coverage of exhaled breath condensate. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 01; 1061-1062:17-25. PMID: 28697414.
      View in: PubMed
    8. Schivo M, Albertson TE, Haczku A, Kenyon NJ, Zeki AA, Kuhn BT, Louie S, Avdalovic MV. Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease. J Investig Med. 2017 Aug; 65(6):953-963. PMID: 28258130.
      View in: PubMed
    9. Nguyen DV, Linderholm A, Haczku A, Kenyon N. Obesity-related, metabolic asthma: a new role for glucagon-like peptide 1 agonists. Lancet Respir Med. 2017 03; 5(3):162-164. PMID: 28266322.
      View in: PubMed
    10. Cagle LA, Franzi LM, Epstein SE, Kass PH, Last JA, Kenyon NJ. Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol. Anesthesiol Res Pract. 2017; 2017:9161040. PMID: 28210272.
      View in: PubMed
    11. Zeki AA, Yeganeh B, Kenyon NJ, Ghavami S. Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II). Curr Mol Pharmacol. 2017; 10(2):74-76. PMID: 28440195.
      View in: PubMed
    12. Zamuruyev KO, Aksenov AA, Pasamontes A, Brown JF, Pettit DR, Foutouhi S, Weimer BC, Schivo M, Kenyon NJ, Delplanque JP, Davis CE. Human breath metabolomics using an optimized non-invasive exhaled breath condensate sampler. J Breath Res. 2016 12 22; 11(1):016001. PMID: 28004639.
      View in: PubMed
    13. Sriratanaviriyakul N, Kivler C, Vidovszky TJ, Yoneda KY, Kenyon NJ, Murin S, Louie S. LINX®, a novel treatment for patients with refractory asthma complicated by gastroesophageal reflux disease: a case report. J Med Case Rep. 2016 May 24; 10(1):124. PMID: 27220906; PMCID: PMC4878099.
      View in: PubMed, PubMed Central
    14. Tan LD, Bratt JM, Godor D, Louie S, Kenyon NJ. Benralizumab: a unique IL-5 inhibitor for severe asthma. J Asthma Allergy. 2016; 9:71-81. PMID: 27110133; PMCID: PMC4831605.
      View in: PubMed, PubMed Central
    15. Zeki AA, Bratt JM, Chang KY, Franzi LM, Ott S, Silveria M, Fiehn O, Last JA, Kenyon NJ. Intratracheal instillation of pravastatin for the treatment of murine allergic asthma: a lung-targeted approach to deliver statins. Physiol Rep. 2015 May 11; 3(5). PMID: 25969462; PMCID: PMC4463814.
      View in: PubMed, PubMed Central
    16. Calhoun G, Wang L, Almeida LE, Kenyon N, Afsar N, Nouraie M, Finkel JC, Quezado ZM. Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice. Eur J Pharmacol. 2015 May 05; 754:125-33. PMID: 25724786; PMCID: PMC4397100.
      View in: PubMed, PubMed Central
    17. Kenyon N, Zeki AA, Albertson TE, Louie S. Definition of critical asthma syndromes. Clin Rev Allergy Immunol. 2015 Feb; 48(1):1-6. PMID: 24213844.
      View in: PubMed
    18. Yang J, Bratt J, Franzi L, Liu JY, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2015 Jan; 52(1):46-55. PMID: 24922186; PMCID: PMC4370250.
      View in: PubMed, PubMed Central
    19. Almeida LE, Kamimura S, Kenyon N, Khaibullina A, Wang L, de Souza Batista CM, Quezado ZM. Validation of a method to directly and specifically measure nitrite in biological matrices. Nitric Oxide. 2015 Feb 15; 45:54-64. PMID: 25445633.
      View in: PubMed
    20. Linderholm AL, Bratt JM, Schuster GU, Zeki AA, Kenyon NJ. Novel therapeutic strategies for adult obese asthmatics. Immunol Allergy Clin North Am. 2014 Nov; 34(4):809-23. PMID: 25282293; PMCID: PMC4185374.
      View in: PubMed, PubMed Central
    21. Zamuruyev KO, Bardaweel HK, Carron CJ, Kenyon NJ, Brand O, Delplanque JP, Davis CE. Continuous droplet removal upon dropwise condensation of humid air on a hydrophobic micropatterned surface. Langmuir. 2014 Aug 26; 30(33):10133-42. PMID: 25073014; PMCID: PMC4148149.
      View in: PubMed, PubMed Central
    22. Kenyon NJ, Bratt JM, Lee J, Luo J, Franzi LM, Zeki AA, Lam KS. Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. PLoS One. 2013; 8(10):e77730. PMID: 24204939; PMCID: PMC3808398.
      View in: PubMed, PubMed Central
    23. Zeki AA, Oldham J, Wilson M, Fortenko O, Goyal V, Last M, Last A, Patel A, Last JA, Kenyon NJ. Statin use and asthma control in patients with severe asthma. BMJ Open. 2013 Aug 13; 3(8). PMID: 23943778; PMCID: PMC3752054.
      View in: PubMed, PubMed Central
    24. Chang S, Linderholm A, Franzi L, Kenyon N, Grasberger H, Harper R. Dual oxidase regulates neutrophil recruitment in allergic airways. Free Radic Biol Med. 2013 Dec; 65:38-46. PMID: 23770197.
      View in: PubMed
    25. Schivo M, Seichter F, Aksenov AA, Pasamontes A, Peirano DJ, Mizaikoff B, Kenyon NJ, Davis CE. A mobile instrumentation platform to distinguish airway disorders. J Breath Res. 2013 Mar; 7(1):017113. PMID: 23446184; PMCID: PMC3633523.
      View in: PubMed, PubMed Central
    26. Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE. Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy. Eur Respir J. 2013 Aug; 42(2):350-61. PMID: 23180589.
      View in: PubMed
    27. Price D, Kenyon NJ, Stollenwerk N. A fresh look at paralytics in the critically ill: real promise and real concern. Ann Intensive Care. 2012 Oct 12; 2(1):43. PMID: 23062076; PMCID: PMC3519794.
      View in: PubMed, PubMed Central
    28. Louie S, Morrissey BM, Kenyon NJ, Albertson TE, Avdalovic M. The critically ill asthmatic--from ICU to discharge. Clin Rev Allergy Immunol. 2012 Aug; 43(1-2):30-44. PMID: 21573915.
      View in: PubMed
    29. Kenyon NJ, Morrissey BM, Schivo M, Albertson TE. Occupational asthma. Clin Rev Allergy Immunol. 2012 Aug; 43(1-2):3-13. PMID: 21573916.
      View in: PubMed
    30. Zeki AA, Kenyon NJ, Yoneda K, Louie S. The adult asthmatic. Clin Rev Allergy Immunol. 2012 Aug; 43(1-2):138-55. PMID: 21424682.
      View in: PubMed
    31. Zeki AA, Thai P, Kenyon NJ, Wu R. Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells. Respir Res. 2012 May 14; 13:38. PMID: 22583375; PMCID: PMC3445818.
      View in: PubMed, PubMed Central
    32. Kenyon N, Liu FT. Pulmonary effects of diesel exhaust: neutrophilic inflammation, oxidative injury, and asthma. Am J Pathol. 2011 Dec; 179(6):2678-82. PMID: 22005277; PMCID: PMC3263604.
      View in: PubMed, PubMed Central
    33. Bratt JM, Zeki AA, Last JA, Kenyon NJ. Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma. J Biomed Res. 2011 Sep; 25(5):299-308. PMID: 23554705; PMCID: PMC3596726.
      View in: PubMed, PubMed Central
    34. Liu J, Sakurai R, O'Roark EM, Kenyon NJ, Torday JS, Rehan VK. PPAR? agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring. Am J Physiol Lung Cell Mol Physiol. 2011 May; 300(5):L710-7. PMID: 21355041; PMCID: PMC3094026.
      View in: PubMed, PubMed Central
    35. Zeki AA, Kenyon NJ, Goldkorn T. Statin drugs, metabolic pathways, and asthma: a therapeutic opportunity needing further research. Drug Metab Lett. 2011 Jan; 5(1):40-4. PMID: 21198438.
      View in: PubMed
    36. Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? Transl Res. 2010 Dec; 156(6):335-49. PMID: 21078495; PMCID: PMC2990975.
      View in: PubMed, PubMed Central
    37. Bratt JM, Williams K, Rabowsky MF, Last MS, Franzi LM, Last JA, Kenyon NJ. Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent. Mediators Inflamm. 2010; 2010. PMID: 20953358; PMCID: PMC2952819.
      View in: PubMed, PubMed Central
    38. Strand N, Bhushan A, Schivo M, Kenyon NJ, Davis CE. Chemically Polymerized Polypyrrole for On-Chip Concentration of Volatile Breath Metabolites. Sens Actuators B Chem. 2010 Jan 07; 143(2):516-523. PMID: 20161533.
      View in: PubMed
    39. Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. Endogenous Levels of Five Fatty Acid Metabolites in Exhaled Breath Condensate to Monitor Asthma by High-Performance Liquid Chromatography: Electrospray Tandem Mass Spectrometry. IEEE Sens J. 2010 Jan 01; 10(1):123-130. PMID: 21103452.
      View in: PubMed
    40. Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, Rosenquist GL, Louie S. Geoepidemiology of COPD and idiopathic pulmonary fibrosis. J Autoimmun. 2010 May; 34(3):J327-38. PMID: 20018478.
      View in: PubMed
    41. Bratt JM, Franzi LM, Linderholm AL, O'Roark EM, Kenyon NJ, Last JA. Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2010 Jan 01; 242(1):1-8. PMID: 19800904; PMCID: PMC3221650.
      View in: PubMed, PubMed Central
    42. De Cruz SJ, Kenyon NJ, Sandrock CE. Bench-to-bedside review: the role of nitric oxide in sepsis. Expert Rev Respir Med. 2009 Oct; 3(5):511-21. PMID: 20477340.
      View in: PubMed
    43. Zeki AA, Franzi L, Last J, Kenyon NJ. Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):731-40. PMID: 19608720; PMCID: PMC2778150.
      View in: PubMed, PubMed Central
    44. Asmuth D, Wun T, Mullen N, Garcia E, Chedin E, Whitney E, Gillis M, Anderson K, Tarantal A, Kenyon N, Curry FR, Berglund L. UC Davis CTSA: coming of age: integrated programs help put the spotlight on clinical and translational science. Clin Transl Sci. 2009 Apr; 2(2):98-101. PMID: 20443878.
      View in: PubMed
    45. Kenyon NJ, Liu R, O'Roark EM, Huang W, Peng L, Lam KS. An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice. Eur J Pharmacol. 2009 Jan 28; 603(1-3):138-46. PMID: 19103195; PMCID: PMC2646171.
      View in: PubMed, PubMed Central
    46. Bratt JM, Franzi LM, Linderholm AL, Last MS, Kenyon NJ, Last JA. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol. 2009 Feb 01; 234(3):273-80. PMID: 19027033; PMCID: PMC2666129.
      View in: PubMed, PubMed Central
    47. Molina MA, Zhao W, Sankaran S, Schivo M, Kenyon NJ, Davis CE. Design-of-experiment optimization of exhaled breath condensate analysis using a miniature differential mobility spectrometer (DMS). Anal Chim Acta. 2008 Nov 03; 628(2):155-61. PMID: 18929003; PMCID: PMC2600869.
      View in: PubMed, PubMed Central
    48. Loyola BR, Bhushan A, Schivo M, Kenyon NJ, Davis CE. Temperature changes in exhaled breath condensate collection devices affect observed acetone concentrations. J Breath Res. 2008 Sep; 2(3):037005. PMID: 21386166.
      View in: PubMed
    49. Lim Y, Vasu VT, Valacchi G, Leonard S, Aung HH, Schock BC, Kenyon NJ, Li CS, Traber MG, Cross CE. Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model. Free Radic Res. 2008 Apr; 42(4):387-96. PMID: 18404538; PMCID: PMC2770006.
      View in: PubMed, PubMed Central
    50. Kenyon NJ, Bratt JM, Linderholm AL, Last MS, Last JA. Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences. Toxicol Appl Pharmacol. 2008 Aug 01; 230(3):269-75. PMID: 18439639; PMCID: PMC2578817.
      View in: PubMed, PubMed Central
    51. Schuster GU, Kenyon NJ, Stephensen CB. Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol. 2008 Feb 01; 180(3):1834-42. PMID: 18209081.
      View in: PubMed
    52. Mealey FH, Kenyon NJ, Avdalovic MV, Louie S. Difficult-to-control asthma in adults. Am J Med. 2007 Sep; 120(9):760-3. PMID: 17765041.
      View in: PubMed
    53. Kenyon NJ, Last MS, Eiserich JP, Morrissey BM, Temple LM, Last JA. Differentiation of the roles of NO from airway epithelium and inflammatory cells in ozone-induced lung inflammation. Toxicol Appl Pharmacol. 2006 Sep 15; 215(3):250-9. PMID: 16643973; PMCID: PMC1594585.
      View in: PubMed, PubMed Central
    54. Last JA, Gohil K, Mathrani VC, Kenyon NJ. Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicol Appl Pharmacol. 2005 Oct 15; 208(2):117-26. PMID: 16183385.
      View in: PubMed
    55. Last JA, Ward R, Temple L, Pinkerton KE, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ultrafine particles. Inhal Toxicol. 2004 Feb; 16(2):93-102. PMID: 15204782.
      View in: PubMed
    56. Last JA, Ward R, Temple L, Kenyon NJ. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. Inhal Toxicol. 2004 Jan; 16(1):33-43. PMID: 14744663.
      View in: PubMed
    57. Kenyon NJ, Jarjour NN. Severe asthma. Clin Rev Allergy Immunol. 2003 Oct; 25(2):131-49. PMID: 14573881.
      View in: PubMed
    58. Kenyon NJ, Gohil K, Last JA. Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: mechanisms and consequences. Toxicol Appl Pharmacol. 2003 Aug 15; 191(1):2-11. PMID: 12915099.
      View in: PubMed
    59. Kenyon NJ, Ward RW, Last JA. Airway fibrosis in a mouse model of airway inflammation. Toxicol Appl Pharmacol. 2003 Jan 15; 186(2):90-100. PMID: 12639500.
      View in: PubMed
    60. Kenyon NJ, van der Vliet A, Schock BC, Okamoto T, McGrew GM, Last JA. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L540-5. PMID: 11839550.
      View in: PubMed
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