Ruiwu Liu

Title(s)Researcher, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
Address4635 2nd Ave., Research Building I, room 2208
CA 95817
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    Collapse Biography 
    Collapse Education and Training
    West China University of Medical Sciences , Chengdu, P.R. ChinaBS07/1990Medicinal Chemistry
    Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. ChinaPhD07/1995Medicinal Chemistry
    UC Davis, School of Medicine, Sacramento, CA, USAPostdoc10/2004Combinatorial Chemistry

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    Collapse Research Activities and Funding
    Integrin-Targeting Transformable Nanomedicine for treatment of Non-small Cell Lung Cancer
    DoD CDMRP LCRP HT9425-23-1-0358Jul 1, 2023 - Jun 30, 2025
    Role: Principal Investigator
    Description: The goal is to develop a novel pre-targeting two-component two-step (TCTS) transformable peptide nanoparticle (TNP) platform for treatment of NSCLC
    A novel small molecule targeting protein translation for pancreatic cancer treatment
    NIH/NCI 1R21CA273506-01Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Description: The objective of this project is to develop our novel small molecule into an effective new drug combination for pancreatic ductal adenocarcinoma .
    A Novel Class of Galectin-1 Inhibitors for Prostate Cancer Therapy
    DoD CDMRP PCRP W81XWH1910727Sep 15, 2019 - Sep 14, 2023
    Role: Principal Investigator
    Description: The goal of this project is to determine the mechanism of galectin-1 (Gal-1) involvement in docetaxel resistance, and investigate whether the newly identified Gal-1 inhibitor S-LLS30 sensitizes non-responders of docetaxel to this chemotherapeutic agent in AR positive and AR-negative CRPC tumors.
    Rapid development of neutralizing antiserum against Zika virus
    NIH R21AI132458Aug 17, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Dual imaging and therapeutic targeting agents for glioblastoma
    NIH R21CA135345Jul 1, 2008 - Jun 30, 2011
    Role: Principal Investigator

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engineered multi-functional, pro-angiogenic collagen-based scaffolds loaded with endothelial cells promote large deep burn wound healing. Front Pharmacol. 2023; 14:1125209. Song H, Gao K, Hao D, Li A, Liu R, Anggito B, Yin B, Jin Q, Dartora V, Lam KS, Smith LR, Panitch A, Zhou J, Farmer DL, Wang A. PMID: 36937891; PMCID: PMC10014525.
      View in: PubMed   Mentions: 2  
    2. Site-Specific Albumin-Selective Ligation to Human Serum Albumin under Physiological Conditions. Bioconjug Chem. 2022 12 21; 33(12):2332-2340. Yu X, Ruan M, Wang Y, Nguyen A, Xiao W, Ajena Y, Solano LN, Liu R, Lam KS. PMID: 36350013; PMCID: PMC9782315.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Programmable Bispecific Nano-immunoengager That Captures T Cells and Reprograms Tumor Microenvironment. Nano Lett. 2022 09 14; 22(17):6866-6876. Zhang L, Bo R, Wu Y, Li L, Zhu Z, Ma AH, Xiao W, Huang Y, Rojalin T, Yin X, Mao C, Wang F, Wang Y, Zhang H, Low KE, Lee K, Ajena Y, Jing D, Zhang D, Baehr CM, Liu R, Wang L, Li Y, Lam KS. PMID: 35926215; PMCID: PMC9479133.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Nuclear receptor RORγ inverse agonists/antagonists display tissue- and gene-context selectivity through distinct activities in altering chromatin accessibility and master regulator SREBP2 occupancy. Pharmacol Res. 2022 08; 182:106324. Zou H, Yang Y, Shi Z, Wu X, Liu R, Yu AM, Chen HW. PMID: 35750301; PMCID: PMC10158160.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Discovery and Characterization of a Potent Antifungal Peptide through One-Bead, One-Compound Combinatorial Library Screening. ACS Infect Dis. 2022 07 08; 8(7):1291-1302. Bansal S, Vu K, Liu R, Ajena Y, Xiao W, Menon SM, Bennett A, Gelli A, Lam KS. PMID: 35700987.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects. Bioact Mater. 2023 Feb; 20:179-193. Hao D, Liu R, Fernandez TG, Pivetti C, Jackson JE, Kulubya ES, Jiang HJ, Ju HY, Liu WL, Panitch A, Lam KS, Leach JK, Farmer DL, Wang A. PMID: 35663336; PMCID: PMC9160290.
      View in: PubMed   Mentions: 2  
    7. Novel Stilbene-Nitroxyl Hybrid Compounds Display Discrete Modulation of Amyloid Beta Toxicity and Structure. Front Chem. 2022; 10:896386. Hilt S, Liu R, Maezawa I, Rojalin T, Aung HH, Budamagunta M, Slez R, Gong Q, Carney RP, Voss JC. PMID: 35720993; PMCID: PMC9204515.
      View in: PubMed   Mentions: 1  
    8. A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation. BMC Pharmacol Toxicol. 2020 11 13; 21(1):76. Jiang M, Liu L, Liu R, Lam KS, Lane NE, Yao W. PMID: 33187558; PMCID: PMC7664094.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Identification of osteogenic progenitor cell-targeted peptides that augment bone formation. Nat Commun. 2020 08 27; 11(1):4278. Jiang M, Liu R, Liu L, Kot A, Liu X, Xiao W, Jia J, Li Y, Lam KS, Yao W. PMID: 32855388; PMCID: PMC7453024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    10. Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization. Front Bioeng Biotechnol. 2020; 8:890. Hao D, Liu R, Gao K, He C, He S, Zhao C, Sun G, Farmer DL, Panitch A, Lam KS, Wang A. PMID: 32850742; PMCID: PMC7403189.
      View in: PubMed   Mentions: 5  
    11. Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization. Front Bioeng Biotechnol. 2020; 8:633. Hao D, Swindell HS, Ramasubramanian L, Liu R, Lam KS, Farmer DL, Wang A. PMID: 32671037; PMCID: PMC7329993.
      View in: PubMed   Mentions: 24  
    12. Discovery and mechanistic characterization of a structurally-unique membrane active peptide. Biochim Biophys Acta Biomembr. 2020 10 01; 1862(10):183394. Bansal S, Su WC, Budamagunta M, Xiao W, Ajena Y, Liu R, Voss JC, Carney RP, Parikh AN, Lam KS. PMID: 32562695; PMCID: PMC7478859.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomater. 2020 05; 108:178-193. Hao D, Fan Y, Xiao W, Liu R, Pivetti C, Walimbe T, Guo F, Zhang X, Farmer DL, Wang F, Panitch A, Lam KS, Wang A. PMID: 32151698; PMCID: PMC8012081.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    14. Surface modification of polymeric electrospun scaffolds via a potent and high-affinity integrin α4β1 ligand improved the adhesion, spreading and survival of human chorionic villus-derived mesenchymal stem cells: a new insight for fetal tissue engineering. J Mater Chem B. 2020 02 26; 8(8):1649-1659. Hao D, Ma B, He C, Liu R, Farmer DL, Lam KS, Wang A. PMID: 32011618; PMCID: PMC7353926.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    15. Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing. Stem Cells. 2020 02; 38(2):231-245. Marusina AI, Merleev AA, Luna JI, Olney L, Haigh NE, Yoon D, Guo C, Ovadia EM, Shimoda M, Luxardi G, Boddu S, Lal NN, Takada Y, Lam KS, Liu R, Isseroff RR, Le S, Nolta JA, Kloxin AM, Maverakis E. PMID: 31648388.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Galectin-1 inhibition induces cell apoptosis through dual suppression of CXCR4 and Ras pathways in human malignant peripheral nerve sheath tumors. Neuro Oncol. 2019 11 04; 21(11):1389-1400. Shih TC, Fan Y, Kiss S, Li X, Deng XN, Liu R, Chen XJ, Carney R, Chen A, Ghosh PM, Lam KS. PMID: 31127849; PMCID: PMC6827838.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Correction to: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 Jul 26; 12(1):83. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31349855; PMCID: PMC6660960.
      View in: PubMed   Mentions: 1     Fields:    
    18. High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 06 10; 12(1):56. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31182116; PMCID: PMC6558829.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    19. Rapid Discovery of Illuminating Peptides for Instant Detection of Opioids in Blood and Body Fluids. Molecules. 2019 May 10; 24(9). Jafari S, Thillier Y, Ajena YH, Shorty D, Li J, Huynh JS, Pan BM, Pan T, Lam KS, Liu R. PMID: 31083395; PMCID: PMC6539258.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing. ACS Comb Sci. 2019 01 14; 21(1):6-10. Li J, Zhao S, Yang G, Liu R, Xiao W, Disano P, Lam KS, Pan T. PMID: 30521316; PMCID: PMC6335607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion. Clin Cancer Res. 2018 09 01; 24(17):4319-4331. Shih TC, Liu R, Wu CT, Li X, Xiao W, Deng X, Kiss S, Wang T, Chen XJ, Carney R, Kung HJ, Duan Y, Ghosh PM, Lam KS. PMID: 29666302; PMCID: PMC6125207.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    22. Microfluidic Print-to-Synthesis Platform for Efficient Preparation and Screening of Combinatorial Peptide Microarrays. Anal Chem. 2018 05 01; 90(9):5833-5840. Li J, Carney RP, Liu R, Fan J, Zhao S, Chen Y, Lam KS, Pan T. PMID: 29633611.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Corrigendum to 'Tumor-targeting peptides from combinatorial libraries' [Adv Drug Deliv Rev.110-111 (2017) 13-37]. Adv Drug Deliv Rev. 2018 02 01; 125:152. Liu R, Li X, Xiao W, Lam KS. PMID: 29530341.
      View in: PubMed   Mentions: 4     Fields:    
    24. Single-Bead Quantification of Peptide Loading Distribution for One-Bead One-Compound Library Synthesis Using Confocal Raman Spectroscopy. Anal Chem. 2017 07 05; 89(13):7000-7008. Tang Y, Thillier Y, Liu R, Li X, Lam KS, Gao T. PMID: 28530391.
      View in: PubMed   Mentions: 2     Fields:    
    25. Combinatorial chemistry in drug discovery. Curr Opin Chem Biol. 2017 Jun; 38:117-126. Liu R, Li X, Lam KS. PMID: 28494316; PMCID: PMC5645069.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    26. Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides. ACS Comb Sci. 2017 05 08; 19(5):299-307. Carney RP, Thillier Y, Kiss Z, Sahabi A, Heleno Campos JC, Knudson A, Liu R, Olivos D, Saunders M, Tian L, Lam KS. PMID: 28378995; PMCID: PMC5901688.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. A Novel Galectin-1 Inhibitor Discovered through One-Bead Two-Compound Library Potentiates the Antitumor Effects of Paclitaxel in vivo. Mol Cancer Ther. 2017 07; 16(7):1212-1223. Shih TC, Liu R, Fung G, Bhardwaj G, Ghosh PM, Lam KS. PMID: 28396365; PMCID: PMC5516795.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. ITK inhibition for the targeted treatment of CTCL. J Dermatol Sci. 2017 Jul; 87(1):88-91. Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E. PMID: 28434812; PMCID: PMC6459605.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides. Adv Biosyst. 2017 May; 1(5). Carney RP, Hazari S, Rojalin T, Knudson A, Gao T, Tang Y, Liu R, Viitala T, Yliperttula M, Lam KS. PMID: 29911169; PMCID: PMC6001286.
      View in: PubMed   Mentions: 19     Fields:    
    30. Synthesis of two fluorescent GTPγS molecules and their biological relevance. Nucleosides Nucleotides Nucleic Acids. 2017 Jun 03; 36(6):379-391. Trans DJ, Bai R, Addison JB, Liu R, Hamel E, Coleman MA, Henderson PT. PMID: 28282254; PMCID: PMC5522600.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    31. The C-reactive protein/albumin ratio, a validated prognostic score, predicts outcome of surgical renal cell carcinoma patients. BMC Cancer. 2017 03 06; 17(1):171. Guo S, He X, Chen Q, Yang G, Yao K, Dong P, Ye Y, Chen D, Zhang Z, Qin Z, Liu Z, Xue Y, Zhang M, Liu R, Zhou F, Han H. PMID: 28264659; PMCID: PMC5339967.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    32. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 04 21; 12(4):1075-1086. Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. PMID: 28195700; PMCID: PMC5875449.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    33. Improved Mobilization of Exogenous Mesenchymal Stem Cells to Bone for Fracture Healing and Sex Difference. Stem Cells. 2016 10; 34(10):2587-2600. Yao W, Lay YE, Kot A, Liu R, Zhang H, Chen H, Lam K, Lane NE. PMID: 27334693; PMCID: PMC5690802.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    34. Tumor-targeting peptides from combinatorial libraries. Adv Drug Deliv Rev. 2017 02; 110-111:13-37. Liu R, Li X, Xiao W, Lam KS. PMID: 27210583; PMCID: PMC5856482.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    35. The Effect of Preoperative Apolipoprotein A-I on the Prognosis of Surgical Renal Cell Carcinoma: A Retrospective Large Sample Study. Medicine (Baltimore). 2016 Mar; 95(12):e3147. Guo S, He X, Chen Q, Yang G, Yao K, Dong P, Ye Y, Chen D, Zhang Z, Qin Z, Liu Z, Li Z, Xue Y, Zhang M, Liu R, Zhou F, Han H. PMID: 27015197; PMCID: PMC4998392.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    36. Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors. EJNMMI Res. 2016 Dec; 6(1):18. Xiao W, Li T, Bononi FC, Lac D, Kekessie IA, Liu Y, Sanchez E, Mazloom A, Ma AH, Lin J, Tran J, Yang K, Lam KS, Liu R. PMID: 26922417; PMCID: PMC4769701.
      View in: PubMed   Mentions: 16  
    37. Covalent Chemical Ligation Strategy for Mono- and Polyclonal Immunoglobulins at Their Nucleotide Binding Sites. Bioconjug Chem. 2016 Jan 20; 27(1):159-69. Lac D, Feng C, Bhardwaj G, Le H, Tran J, Xing L, Fung G, Liu R, Cheng H, Lam KS. PMID: 26630124.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries. Cell Mol Immunol. 2017 Mar; 14(3):308-318. Leung NY, Wai CY, Ho MH, Liu R, Lam KS, Wang JJ, Shu SA, Chu KH, Leung PS. PMID: 26364917; PMCID: PMC5360880.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries. Methods Mol Biol. 2015; 1248:3-22. Liu R, Shih TC, Deng X, Anwar L, Ahadi S, Kumaresan P, Lam KS. PMID: 25616322; PMCID: PMC4625904.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    40. Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. Cell Death Dis. 2014 Sep 04; 5:e1409. Guo W, Liu R, Bhardwaj G, Yang JC, Changou C, Ma AH, Mazloom A, Chintapalli S, Xiao K, Xiao W, Kumaresan P, Sanchez E, Yeh CT, Evans CP, Patterson R, Lam KS, Kung HJ. PMID: 25188519; PMCID: PMC4540187.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014 Jul 24; 57(14):5975-85. Chu CH, Wang LY, Hsu KC, Chen CC, Cheng HH, Wang SM, Wu CM, Chen TJ, Li LT, Liu R, Hung CL, Yang JM, Kung HJ, Wang WC. PMID: 24971742; PMCID: PMC4216216.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    42. Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin. Nanomedicine (Lond). 2014; 9(12):1807-20. Zhang H, Li Y, Lin TY, Xiao K, Haddad AS, Henderson PT, Jonas BA, Chen M, Xiao W, Liu R, Lam KS, Pan CX. PMID: 24628688; PMCID: PMC4167557.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Reversing bone loss by directing mesenchymal stem cells to bone. Stem Cells. 2013 Sep; 31(9):2003-14. Yao W, Guan M, Jia J, Dai W, Lay YA, Amugongo S, Liu R, Olivos D, Saunders M, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. PMID: 23818248; PMCID: PMC3795809.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    44. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PLoS One. 2013; 8(8):e70910. Guo W, Liu R, Bhardwaj G, Ma AH, Changou C, Yang JC, Li Y, Feng C, Luo Y, Mazloom A, Sanchez E, Wang Y, Huang W, Patterson R, Evans CP, Lam KS, Kung HJ. PMID: 23967135; PMCID: PMC3744530.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    45. Immobilized OBOC combinatorial bead array to facilitate multiplicative screening. Comb Chem High Throughput Screen. 2013 Jul; 16(6):441-448. Xiao W, Bononi FC, Townsend J, Li Y, Liu R, Lam KS. PMID: 23488896; PMCID: PMC4560360.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    46. Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer. Future Med Chem. 2013 Jun; 5(9):991-4. Liu R, Wettersten HI, Park SH, Weiss RH. PMID: 23734682; PMCID: PMC4573579.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    47. Synthesis and characterization of a novel inhibitor of C-reactive protein-mediated proinflammatory effects. Metab Syndr Relat Disord. 2013 Jun; 11(3):177-84. Kumaresan PR, Devaraj S, Huang W, Lau EY, Liu R, Lam KS, Jialal I. PMID: 23445482; PMCID: PMC3848264.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    48. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43. Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. PMID: 23362666; PMCID: PMC4562383.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3. Bioorg Med Chem Lett. 2013 Jan 01; 23(1):340-5. Ye L, Dickerson T, Kaur H, Takada YK, Fujita M, Liu R, Knapp JM, Lam KS, Schore NE, Kurth MJ, Takada Y. PMID: 23164706; PMCID: PMC4570851.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    50. Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol Pharmacol. 2012 Nov; 82(5):938-47. Guo W, Liu R, Ono Y, Ma AH, Martinez A, Sanchez E, Wang Y, Huang W, Mazloom A, Li J, Ning J, Maverakis E, Lam KS, Kung HJ. PMID: 22899868; PMCID: PMC3477223.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. In-vivo biodistribution and safety of 99mTc-LLP2A-HYNIC in canine non-Hodgkin lymphoma. PLoS One. 2012; 7(4):e34404. Zwingenberger AL, Kent MS, Liu R, Kukis DL, Wisner ER, DeNardo SJ, Taylor SL, Chen X, Lam KS. PMID: 22545083; PMCID: PMC3335845.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    52. Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche. J Nucl Med. 2012 May; 53(5):779-86. Shokeen M, Zheleznyak A, Wilson JM, Jiang M, Liu R, Ferdani R, Lam KS, Schwarz JK, Anderson CJ. PMID: 22496586; PMCID: PMC8522701.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    53. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med. 2012 Feb 05; 18(3):456-62. Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE. PMID: 22306732; PMCID: PMC3755884.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    54. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J Clin Invest. 2011 Apr; 121(4):1549-60. Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. PMID: 21403397; PMCID: PMC3069774.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    55. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16; 100(4):1076-82. Li J, Liu R, Lam KS, Jin LW, Duan Y. PMID: 21320453; PMCID: PMC3037571.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    56. Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods. ACS Comb Sci. 2011 May 09; 13(3):259-64. Kumaresan PR, Wang Y, Saunders M, Maeda Y, Liu R, Wang X, Lam KS. PMID: 21302937.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    57. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct; 9(10):2714-23. Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, Liu R, Lightstone FC, Takada Y, Lam KS. PMID: 20858725; PMCID: PMC3571112.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    58. Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries. J Comb Chem. 2010 Sep 13; 12(5):700-12. Townsend JB, Shaheen F, Liu R, Lam KS. PMID: 20593859; PMCID: PMC3045263.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    59. LAS0811: from combinatorial chemistry to activation of antioxidant response element. J Biomed Biotechnol. 2009; 2009:420194. Zhu M, Baek H, Liu R, Song A, Lam K, Lau D. PMID: 19794825; PMCID: PMC2753787.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    60. 111In-LLP2A-DOTA Polyethylene Glycol-Targeting {alpha}4{beta}1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies. J Nucl Med. 2009 Apr; 50(4):625-34. Denardo SJ, Liu R, Albrecht H, Natarajan A, Sutcliffe JL, Anderson C, Peng L, Ferdani R, Cherry SR, Lam KS. PMID: 19289419.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    61. Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. J Med Chem. 2009 Jan 08; 52(1):14-9. Carpenter RD, Andrei M, Aina OH, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 19072684; PMCID: PMC3164867.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    62. Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC combinatorial small molecule libraries. J Comb Chem. 2009 Jan-Feb; 11(1):91-102. Baek HG, Liu R, Lam KS. PMID: 19061339; PMCID: PMC2693237.
      View in: PubMed   Mentions: 6     Fields:    
    63. A novel hydrogel functionalized with specific peptidomimetic ligands for 2-D and 3-D cell culture. Adv Exp Med Biol. 2009; 611:19-20. Luo J, Onofiok E, Shi C, Liu R, Lam KS. PMID: 19400076.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    64. High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers. Cancer Biol Ther. 2008 Dec; 7(12):2015-22. Park SH, Wang X, Liu R, Lam KS, Weiss RH. PMID: 18981726.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice. Eur J Pharmacol. 2009 Jan 28; 603(1-3):138-46. Kenyon NJ, Liu R, O'Roark EM, Huang W, Peng L, Lam KS. PMID: 19103195; PMCID: PMC2646171.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    66. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct; 31(10):1690-9. Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. PMID: 19022536; PMCID: PMC2888733.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    67. Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting alpha 3 integrin. Eur J Nucl Med Mol Imaging. 2009 Jan; 36(1):94-103. Xiao W, Yao N, Peng L, Liu R, Lam KS. PMID: 18712382; PMCID: PMC2842018.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    68. In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin. Mol Cancer Ther. 2008 Feb; 7(2):432-7. Peng L, Liu R, Andrei M, Xiao W, Lam KS. PMID: 18245670.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    69. Screening of a one bead-one compound combinatorial library for beta-actin identifies molecules active toward Ramos B-lymphoma cells. Anal Biochem. 2008 Mar 01; 374(1):112-20. Miyamoto S, Liu R, Hung S, Wang X, Lam KS. PMID: 18023409; PMCID: PMC2770001.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    70. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. PMID: 17953662.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    71. Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin. J Med Chem. 2007 Nov 15; 50(23):5863-7. Carpenter RD, Andrei M, Lau EY, Lightstone FC, Liu R, Lam KS, Kurth MJ. PMID: 17948981.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    72. From combinatorial chemistry to cancer-targeting peptides. Mol Pharm. 2007 Sep-Oct; 4(5):631-51. Aina OH, Liu R, Sutcliffe JL, Marik J, Pan CX, Lam KS. PMID: 17880166.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    73. A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. J Comb Chem. 2007 Jan-Feb; 9(1):143-57. Dixon SM, Milinkevich KA, Fujii J, Liu R, Yao N, Lam KS, Kurth MJ. PMID: 17206843.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    74. Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries. Bioconjug Chem. 2007 Jan-Feb; 18(1):175-82. Kumaresan PR, Natarajan A, Song A, Wang X, Liu R, DeNardo G, DeNardo S, Lam KS. PMID: 17226971.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    75. Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. Nat Chem Biol. 2006 Jul; 2(7):381-9. Peng L, Liu R, Marik J, Wang X, Takada Y, Lam KS. PMID: 16767086.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    76. Peptide ligands targeting integrin alpha3beta1 in non-small cell lung cancer. Lung Cancer. 2006 Jun; 52(3):291-7. Lau D, Guo L, Liu R, Marik J, Lam K. PMID: 16635537.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    77. Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem. 2006 Apr 20; 49(8):2388-97. Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD. PMID: 16610782.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    78. Structure-activity relationship studies of a series of peptidomimetic ligands for alpha(4) beta(1) integrin on Jurkat T-leukemia cells. Biopolymers. 2006; 84(6):595-604. Liu R, Peng L, Han H, Lam KS. PMID: 17041919.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    79. Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2938-42. Dixon S, Robins L, Elling RA, Liu R, Lam KS, Wilson DK, Kurth MJ. PMID: 15911284.
      View in: PubMed   Mentions:    Fields:    
    80. A topologically segregated one-bead-one-compound combinatorial glycopeptide library for identification of lectin ligands. J Comb Chem. 2005 May-Jun; 7(3):372-84. Ying L, Liu R, Zhang J, Lam K, Lebrilla CB, Gervay-Hague J. PMID: 15877466.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    81. Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries. Mol Cancer Ther. 2005 May; 4(5):806-13. Aina OH, Marik J, Liu R, Lau DH, Lam KS. PMID: 15897245.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    82. Partial alloc-deprotection approach for ladder synthesis of "one-bead one-compound" combinatorial libraries. J Comb Chem. 2005 Mar-Apr; 7(2):197-209. Wang X, Peng L, Liu R, Gill SS, Lam KS. PMID: 15762747.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    83. Applications of topologically segregated bilayer beads in 'one-bead one-compound' combinatorial libraries. J Pept Res. 2005 Jan; 65(1):130-8. Wang X, Peng L, Liu R, Xu B, Lam KS. PMID: 15686543.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    84. Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells. Mol Cancer Ther. 2004 Oct; 3(10):1329-34. Mikawa M, Wang H, Guo L, Liu R, Marik J, Takada Y, Lam K, Lau D. PMID: 15486200.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    85. New approaches in identifying drugs to inactivate oncogene products. Semin Cancer Biol. 2004 Feb; 14(1):13-21. Liu R, Hsieh CY, Lam KS. PMID: 14757532.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    86. Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach. J Pept Res. 2003 Dec; 62(6):260-8. Kamath JR, Liu R, Enstrom AM, Lou Q, Lam KS. PMID: 14632929.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    87. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc Chem Res. 2003 Jun; 36(6):370-7. Lam KS, Liu R, Miyamoto S, Lehman AL, Tuscano JM. PMID: 12809522.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    88. High-throughput one-bead-one-compound approach to peptide-encoded combinatorial libraries: MALDI-MS analysis of single TentaGel beads. J Comb Chem. 2003 Mar-Apr; 5(2):125-37. Franz AH, Liu R, Song A, Lam KS, Lebrilla CB. PMID: 12625702.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    89. Combinatorial peptide library methods for immunobiology research. Exp Hematol. 2003 Jan; 31(1):11-30. Liu R, Enstrom AM, Lam KS. PMID: 12543103.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    90. Synthesis and screening of "one-bead one-compound" combinatorial peptide libraries. Methods Enzymol. 2003; 369:298-322. Lam KS, Lehman AL, Song A, Doan N, Enstrom AM, Maxwell J, Liu R. PMID: 14722961.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    91. Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinatorial libraries. Methods Enzymol. 2003; 369:271-87. Liu R, Marik J, Lam KS. PMID: 14722959.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    92. A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J Am Chem Soc. 2002 Jul 03; 124(26):7678-80. Liu R, Marik J, Lam KS. PMID: 12083920.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    93. An unnatural amino acid that induces beta-sheet folding and interaction in peptides. J Am Chem Soc. 2002 May 08; 124(18):4972-3. Nowick JS, Lam KS, Khasanova TV, Kemnitzer WE, Maitra S, Mee HT, Liu R. PMID: 11982357.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    94. Automatic Edman microsequencing of peptides containing multiple unnatural amino acids. Anal Biochem. 2001 Aug 01; 295(1):9-16. Liu R, Lam KS. PMID: 11476539.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    95. [Synthesis and structure-activity relationships of novel 14 beta-side chain taxol derivatives]. Yao Xue Xue Bao. 1998 Dec; 33(12):910-8. Liu R, Yin D, Wang D, Li C, Guo J, Liang X. PMID: 12016856.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    96. [Synthesis and antiulcer activity of 3,4-dihydro-hainanensine analogs]. Yao Xue Xue Bao. 1998 Sep; 33(9):682-7. Liu R, Gao Y, Zhang S, Liang X. PMID: 12016872.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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