Fuzheng Guo

Title(s)	Associate Professor, Neurology
School	School of Veterinary Medicine
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Research

Research Activities and Funding

Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
NIH R01NS123080May 1, 2021 - Feb 28, 2026
Role: Principal Investigator

A paradigm shift in our understanding of oligodendroglial HIFa-regulated CNS angiogenesis
NIH R21NS109790Sep 1, 2018 - Aug 31, 2021
Role: Principal Investigator

The Wnt-independent role of TCF7l2 in CNS myelin formation and repair
NIH R01NS094559Aug 1, 2016 - Jun 30, 2021
Role: Principal Investigator

The curious case of Wnt effector TCF712 in CNS myelination and remyelination
NIH R21NS093559Feb 1, 2016 - Jul 31, 2016
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions. bioRxiv. 2024 Apr 29. Wang Y, Kim B, Gong S, Park J, Zhu M, Wong EM, Park AY, Chernoff J, Guo F. PMID: 38746444; PMCID: PMC11092442.

View in: PubMed Mentions:
Regulation of CNS pathology by Serpina3n/SERPINA3: The knowns and the puzzles. Neuropathol Appl Neurobiol. 2024 Apr; 50(2):e12980. Zhu M, Lan Z, Park J, Gong S, Wang Y, Guo F. PMID: 38647003; PMCID: PMC11131959.

View in: PubMed Mentions: 1 Fields:
Bio Biology Neu Neurology Pat Pathology
Translation:Humans Animals
Dispensable regulation of brain development and myelination by Serpina3n. bioRxiv. 2024 Feb 07. Zhu M, Wang Y, Park J, Gong S, Guo F. PMID: 38370831; PMCID: PMC10871299.

View in: PubMed Mentions:
Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy. Ann Clin Transl Neurol. 2024 Jan 28. Hull VL, Wang Y, McDonough J, Zhu M, Burns T, Al Ramel N, Dehghani A, Guo F, Pleasure D. PMID: 38282243.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice. Glia. 2023 12; 71(12):2832-2849. Hull VL, Wang Y, Burns T, Sternbach S, Gong S, McDonough J, Guo F, Borodinsky LN, Pleasure D. PMID: 37610133; PMCID: PMC10591969.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Humans Animals Cells
SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell Rep. 2022 12 20; 41(12):111842. Wang Y, Zhang S, Lan Z, Doan V, Kim B, Liu S, Zhu M, Hull VL, Rihani S, Zhang CL, Gray JA, Guo F. PMID: 36543123; PMCID: PMC9875714.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression. Glia. 2023 02; 71(2):143-154. Guo F, Wang Y. PMID: 35841271; PMCID: PMC9772070.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Animals Cells
Transmission electron microscopic analysis of myelination in the murine central nervous system. STAR Protoc. 2022 06 17; 3(2):101304. Wang Y, Sun B, Shibata B, Guo F. PMID: 35496778; PMCID: PMC9043565.

View in: PubMed Mentions: 2 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Hypoxia inducible factor and diffuse white matter injury in the premature brain: perspectives from genetic studies in mice. Neural Regen Res. 2022 Jan; 17(1):105-107. Guo F, Zhang S. PMID: 34100442; PMCID: PMC8451551.

View in: PubMed Mentions:
Therapeutic Potentials of Poly (ADP-Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting. Adv Sci (Weinh). 2022 02; 9(5):e2102853. Wang Y, Pleasure D, Deng W, Guo F. PMID: 34935305; PMCID: PMC8844485.

View in: PubMed Mentions: 7 Fields:
Bio Biomedical Engineering
Translation:Humans Animals Cells
Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how. Biol Rev Camb Philos Soc. 2022 04; 97(2):615-639. Wang Y, Guo F. PMID: 34811887; PMCID: PMC8917091.

View in: PubMed Mentions: 2 Fields:
Bio Biology
Translation:Cells
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination. Cell Rep. 2021 10 05; 37(1):109695. Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F. PMID: 34610310; PMCID: PMC9586836.

View in: PubMed Mentions: 21 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2021 11; 90(5):845-850. Wang Y, Hull V, Sternbach S, Popovich B, Burns T, McDonough J, Guo F, Pleasure D. PMID: 34498299; PMCID: PMC9549923.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Animals Cells
The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling. J Neurosci. 2021 02 24; 41(8):1650-1664. Zhang S, Wang Y, Zhu X, Song L, Zhan X, Ma E, McDonough J, Fu H, Cambi F, Grinspan J, Guo F. PMID: 33452226; PMCID: PMC8115879.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Animals Cells
HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021 01 13; 41(2):251-268. Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. PMID: 33208471; PMCID: PMC7810654.

View in: PubMed Mentions: 9 Fields:
Neu Neurology
Translation:Humans Animals Cells
Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nat Commun. 2020 04 24; 11(1):2027. Zhang S, Kim B, Zhu X, Gui X, Wang Y, Lan Z, Prabhu P, Fond K, Wang A, Guo F. PMID: 32332719; PMCID: PMC7181614.

View in: PubMed Mentions: 26 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomater. 2020 05; 108:178-193. Hao D, Fan Y, Xiao W, Liu R, Pivetti C, Walimbe T, Guo F, Zhang X, Farmer DL, Wang F, Panitch A, Lam KS, Wang A. PMID: 32151698; PMCID: PMC8012081.

View in: PubMed Mentions: 21 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2020 03; 87(3):480-485. Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. PMID: 31925837; PMCID: PMC8523037.

View in: PubMed Mentions: 17 Fields:
Neu Neurology
Translation:Animals Cells
Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells. 2019 11 23; 8(12). Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A. PMID: 31771176; PMCID: PMC6952942.

View in: PubMed Mentions: 56 Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem Cells Int. 2019; 2019:9695239. Hao D, He C, Ma B, Lankford L, Reynaga L, Farmer DL, Guo F, Wang A. PMID: 31781252; PMCID: PMC6874947.

View in: PubMed Mentions: 16
Pathophysiology and Treatment of Canavan Disease. Neurochem Res. 2020 03; 45(3):561-565. Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. PMID: 30535831.

View in: PubMed Mentions: 9 Fields:
Che Chemistry Neu Neurology
Translation:Humans Animals Cells
The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol Neurobiol. 2018 Dec; 55(12):9001-9015. Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F. PMID: 29623612; PMCID: PMC6173662.

View in: PubMed Mentions: 18 Fields:
Mol Molecular Biology Neu Neurology
Translation:Animals Cells
Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination. J Neurosci. 2018 02 14; 38(7):1802-1820. Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F. PMID: 29335358; PMCID: PMC5815459.

View in: PubMed Mentions: 45 Fields:
Neu Neurology
Translation:Animals Cells
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 03 07; 26(3):793-800. Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. PMID: 29456021; PMCID: PMC5910673.

View in: PubMed Mentions: 9 Fields:
Mol Molecular Biology The Therapeutics
Translation:Animals Cells
Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 04 21; 12(4):1075-1086. Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. PMID: 28195700; PMCID: PMC5875449.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy. J Neurosci. 2017 01 11; 37(2):413-421. Sohn J, Bannerman P, Guo F, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D. PMID: 28077719; PMCID: PMC5242397.

View in: PubMed Mentions: 10 Fields:
Neu Neurology
Translation:Animals Cells
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res. 2017 01; 235(1):279-292. Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F, Pleasure D, Freeman E, Shriver L, McDonough J. PMID: 27709268; PMCID: PMC5875422.

View in: PubMed Mentions: 24 Fields:
Bra Brain
Translation:Humans Animals Cells
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. Int J Mol Sci. 2016 Apr 20; 17(4). Tian Z, Guo F, Biswas S, Deng W. PMID: 27104529; PMCID: PMC4849048.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Cells
Chronological protein synthesis in regenerating rat liver. Electrophoresis. 2015 Jul; 36(14):1622-32. He J, Hao S, Zhang H, Guo F, Huang L, Xiao X, He D. PMID: 25873423.

View in: PubMed Mentions: Fields:
Che Chemistry Techniques
Translation:Animals Cells
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol. 2015 May; 77(5):884-8. Guo F, Bannerman P, Mills Ko E, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough JA, Pleasure D. PMID: 25712859.

View in: PubMed Mentions: 24 Fields:
Neu Neurology
Translation:Animals
The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling. J Neurosci. 2015 Mar 25; 35(12):5007-22. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. PMID: 25810530; PMCID: PMC6705374.

View in: PubMed Mentions: 50 Fields:
Neu Neurology
Translation:Animals Cells
Canonical Wnt signaling in the oligodendroglial lineage--puzzles remain. Glia. 2015 Oct; 63(10):1671-93. Guo F, Lang J, Sohn J, Hammond E, Chang M, Pleasure D. PMID: 25782433.

View in: PubMed Mentions: 58 Fields:
Neu Neurology
Translation:Humans Animals Cells
The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 04; 35(9):3756-63. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. PMID: 25740506; PMCID: PMC6605576.

View in: PubMed Mentions: 37 Fields:
Neu Neurology
Translation:Animals Cells
Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation. 2014 Jun 12; 11:105. Mills Ko E, Ma JH, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika AM, Pleasure D. PMID: 24924222; PMCID: PMC4066277.

View in: PubMed Mentions: 42 Fields:
Neu Neurology
Translation:Animals Cells
Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci. 2014 Jun 11; 34(24):8175-85. Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika AM, Pleasure D. PMID: 24920622; PMCID: PMC4051973.

View in: PubMed Mentions: 64 Fields:
Neu Neurology
Translation:Animals Cells
Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Dec; 19(12):1275-1283. Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty A, Krishnamurthy A, Tsai MK, Covarrubias D, Wong A, Francis D, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D. PMID: 24514565; PMCID: PMC4128957.

View in: PubMed Mentions: 94 Fields:
Mol Molecular Biology Psy Psychiatry
Translation:Animals Cells
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death Dis. 2013 Mar 14; 4:e546. Chung SH, Guo F, Jiang P, Pleasure DE, Deng W. PMID: 23492777; PMCID: PMC3615735.

View in: PubMed Mentions: 17 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Animals Cells
Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013 Feb 13; 33(7):3113-30. Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, Guo F. PMID: 23407966; PMCID: PMC3711764.

View in: PubMed Mentions: 62 Fields:
Neu Neurology
Translation:Animals Cells
Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. 2013 Oct 15; 333(1-2):55-9. Moreno M, Guo F, Mills Ko E, Bannerman P, Soulika A, Pleasure D. PMID: 23294494; PMCID: PMC3624040.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Humans Animals Cells
PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 2012 Aug 29; 32(35):12152-64. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D. PMID: 22933798; PMCID: PMC3457640.

View in: PubMed Mentions: 11 Fields:
Neu Neurology
Translation:Animals Cells
Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci. 2012 Jan 11; 32(2):639-45. Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D. PMID: 22238099; PMCID: PMC3403747.

View in: PubMed Mentions: 43 Fields:
Neu Neurology
Translation:Animals Cells
Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration. Hepatol Res. 2011 Dec; 41(12):1230-9. Wu Y, Guo F, Liu J, Xiao X, Huang L, He D. PMID: 21917088.

View in: PubMed Mentions: 4
Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci. 2011 Aug 17; 31(33):11914-28. Guo F, Maeda Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D. PMID: 21849552; PMCID: PMC3167226.

View in: PubMed Mentions: 39 Fields:
Neu Neurology
Translation:Animals Cells
Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci. 2010 Sep 08; 30(36):12036-49. Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. PMID: 20826667; PMCID: PMC2940828.

View in: PubMed Mentions: 85 Fields:
Neu Neurology
Translation:Animals Cells
Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci. 2009 Jun 03; 29(22):7256-70. Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. PMID: 19494148; PMCID: PMC2717630.

View in: PubMed Mentions: 78 Fields:
Neu Neurology
Translation:Animals Cells
A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS One. 2008 Aug 20; 3(8):e2991. Zhang Z, Chen J, Guo F, He L, Wu Y, Zeng C, Xiao X, He D. PMID: 18714357; PMCID: PMC2500177.

View in: PubMed Mentions: 1 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics. 2006 May; 6(10):3075-86. Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D. PMID: 16619303.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Animals Cells
Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Sci China C Life Sci. 2004 Jun; 47(3):219-23. Xiao X, Zhao X, Liu J, Guo F, Liu D, He D. PMID: 15524278.

View in: PubMed Mentions: 3 Fields:
Bio Biology Sci Science
Translation:Humans
Development of proteomic patterns for detecting lung cancer. Dis Markers. 2003-2004; 19(1):33-9. Xiao X, Liu D, Tang Y, Guo F, Xia L, Liu J, He D. PMID: 14757945; PMCID: PMC3851077.

View in: PubMed Mentions: 17 Fields:
Bio Biochemistry
Translation:Humans