Fuzheng Guo

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
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    Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology
    NIH R01NS123080May 1, 2021 - Feb 28, 2026
    Role: Principal Investigator
    A paradigm shift in our understanding of oligodendroglial HIFa-regulated CNS angiogenesis
    NIH R21NS109790Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    The Wnt-independent role of TCF7l2 in CNS myelin formation and repair
    NIH R01NS094559Aug 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    The curious case of Wnt effector TCF712 in CNS myelination and remyelination
    NIH R21NS093559Feb 1, 2016 - Jul 31, 2016
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dispensable regulation of brain development and myelination by Serpina3n. bioRxiv. 2024 Feb 07. Zhu M, Wang Y, Park J, Gong S, Guo F. PMID: 38370831; PMCID: PMC10871299.
      View in: PubMed   Mentions:
    2. Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy. Ann Clin Transl Neurol. 2024 Jan 28. Hull VL, Wang Y, McDonough J, Zhu M, Burns T, Al Ramel N, Dehghani A, Guo F, Pleasure D. PMID: 38282243.
      View in: PubMed   Mentions:    Fields:    
    3. Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice. Glia. 2023 12; 71(12):2832-2849. Hull VL, Wang Y, Burns T, Sternbach S, Gong S, McDonough J, Guo F, Borodinsky LN, Pleasure D. PMID: 37610133; PMCID: PMC10591969.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell Rep. 2022 12 20; 41(12):111842. Wang Y, Zhang S, Lan Z, Doan V, Kim B, Liu S, Zhu M, Hull VL, Rihani S, Zhang CL, Gray JA, Guo F. PMID: 36543123; PMCID: PMC9875714.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. TCF7l2, a nuclear marker that labels premyelinating oligodendrocytes and promotes oligodendroglial lineage progression. Glia. 2023 02; 71(2):143-154. Guo F, Wang Y. PMID: 35841271; PMCID: PMC9772070.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Transmission electron microscopic analysis of myelination in the murine central nervous system. STAR Protoc. 2022 06 17; 3(2):101304. Wang Y, Sun B, Shibata B, Guo F. PMID: 35496778; PMCID: PMC9043565.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Hypoxia inducible factor and diffuse white matter injury in the premature brain: perspectives from genetic studies in mice. Neural Regen Res. 2022 Jan; 17(1):105-107. Guo F, Zhang S. PMID: 34100442; PMCID: PMC8451551.
      View in: PubMed   Mentions:
    8. Therapeutic Potentials of Poly (ADP-Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting. Adv Sci (Weinh). 2022 02; 9(5):e2102853. Wang Y, Pleasure D, Deng W, Guo F. PMID: 34935305; PMCID: PMC8844485.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Group I PAKs in myelin formation and repair of the central nervous system: what, when, and how. Biol Rev Camb Philos Soc. 2022 04; 97(2):615-639. Wang Y, Guo F. PMID: 34811887; PMCID: PMC8917091.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    10. PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination. Cell Rep. 2021 10 05; 37(1):109695. Wang Y, Zhang Y, Zhang S, Kim B, Hull VL, Xu J, Prabhu P, Gregory M, Martinez-Cerdeno V, Zhan X, Deng W, Guo F. PMID: 34610310; PMCID: PMC9586836.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    11. Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2021 11; 90(5):845-850. Wang Y, Hull V, Sternbach S, Popovich B, Burns T, McDonough J, Guo F, Pleasure D. PMID: 34498299; PMCID: PMC9549923.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling. J Neurosci. 2021 02 24; 41(8):1650-1664. Zhang S, Wang Y, Zhu X, Song L, Zhan X, Ma E, McDonough J, Fu H, Cambi F, Grinspan J, Guo F. PMID: 33452226; PMCID: PMC8115879.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021 01 13; 41(2):251-268. Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. PMID: 33208471; PMCID: PMC7810654.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nat Commun. 2020 04 24; 11(1):2027. Zhang S, Kim B, Zhu X, Gui X, Wang Y, Lan Z, Prabhu P, Fond K, Wang A, Guo F. PMID: 32332719; PMCID: PMC7181614.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    15. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomater. 2020 05; 108:178-193. Hao D, Fan Y, Xiao W, Liu R, Pivetti C, Walimbe T, Guo F, Zhang X, Farmer DL, Wang F, Panitch A, Lam KS, Wang A. PMID: 32151698; PMCID: PMC8012081.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    16. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2020 03; 87(3):480-485. Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. PMID: 31925837; PMCID: PMC8523037.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells. 2019 11 23; 8(12). Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A. PMID: 31771176; PMCID: PMC6952942.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    18. Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem Cells Int. 2019; 2019:9695239. Hao D, He C, Ma B, Lankford L, Reynaga L, Farmer DL, Guo F, Wang A. PMID: 31781252; PMCID: PMC6874947.
      View in: PubMed   Mentions: 17  
    19. Pathophysiology and Treatment of Canavan Disease. Neurochem Res. 2020 03; 45(3):561-565. Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. PMID: 30535831.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol Neurobiol. 2018 Dec; 55(12):9001-9015. Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F. PMID: 29623612; PMCID: PMC6173662.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination. J Neurosci. 2018 02 14; 38(7):1802-1820. Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F. PMID: 29335358; PMCID: PMC5815459.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    22. Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 03 07; 26(3):793-800. Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. PMID: 29456021; PMCID: PMC5910673.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 04 21; 12(4):1075-1086. Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. PMID: 28195700; PMCID: PMC5875449.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    24. Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy. J Neurosci. 2017 01 11; 37(2):413-421. Sohn J, Bannerman P, Guo F, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D. PMID: 28077719; PMCID: PMC5242397.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res. 2017 01; 235(1):279-292. Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F, Pleasure D, Freeman E, Shriver L, McDonough J. PMID: 27709268; PMCID: PMC5875422.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. Int J Mol Sci. 2016 Apr 20; 17(4). Tian Z, Guo F, Biswas S, Deng W. PMID: 27104529; PMCID: PMC4849048.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    27. Chronological protein synthesis in regenerating rat liver. Electrophoresis. 2015 Jul; 36(14):1622-32. He J, Hao S, Zhang H, Guo F, Huang L, Xiao X, He D. PMID: 25873423.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol. 2015 May; 77(5):884-8. Guo F, Bannerman P, Mills Ko E, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough JA, Pleasure D. PMID: 25712859.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    29. The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling. J Neurosci. 2015 Mar 25; 35(12):5007-22. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. PMID: 25810530; PMCID: PMC6705374.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    30. Canonical Wnt signaling in the oligodendroglial lineage--puzzles remain. Glia. 2015 Oct; 63(10):1671-93. Guo F, Lang J, Sohn J, Hammond E, Chang M, Pleasure D. PMID: 25782433.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    31. The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 04; 35(9):3756-63. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. PMID: 25740506; PMCID: PMC6605576.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    32. Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation. 2014 Jun 12; 11:105. Mills Ko E, Ma JH, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika AM, Pleasure D. PMID: 24924222; PMCID: PMC4066277.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    33. Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci. 2014 Jun 11; 34(24):8175-85. Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika AM, Pleasure D. PMID: 24920622; PMCID: PMC4051973.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    34. Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Dec; 19(12):1275-1283. Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty A, Krishnamurthy A, Tsai MK, Covarrubias D, Wong A, Francis D, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D. PMID: 24514565; PMCID: PMC4128957.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    35. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death Dis. 2013 Mar 14; 4:e546. Chung SH, Guo F, Jiang P, Pleasure DE, Deng W. PMID: 23492777; PMCID: PMC3615735.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013 Feb 13; 33(7):3113-30. Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, Guo F. PMID: 23407966; PMCID: PMC3711764.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    37. Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. 2013 Oct 15; 333(1-2):55-9. Moreno M, Guo F, Mills Ko E, Bannerman P, Soulika A, Pleasure D. PMID: 23294494; PMCID: PMC3624040.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    38. PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 2012 Aug 29; 32(35):12152-64. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D. PMID: 22933798; PMCID: PMC3457640.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci. 2012 Jan 11; 32(2):639-45. Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D. PMID: 22238099; PMCID: PMC3403747.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    40. Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration. Hepatol Res. 2011 Dec; 41(12):1230-9. Wu Y, Guo F, Liu J, Xiao X, Huang L, He D. PMID: 21917088.
      View in: PubMed   Mentions: 4  
    41. Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci. 2011 Aug 17; 31(33):11914-28. Guo F, Maeda Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D. PMID: 21849552; PMCID: PMC3167226.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    42. Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci. 2010 Sep 08; 30(36):12036-49. Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. PMID: 20826667; PMCID: PMC2940828.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    43. Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci. 2009 Jun 03; 29(22):7256-70. Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. PMID: 19494148; PMCID: PMC2717630.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    44. A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS One. 2008 Aug 20; 3(8):e2991. Zhang Z, Chen J, Guo F, He L, Wu Y, Zeng C, Xiao X, He D. PMID: 18714357; PMCID: PMC2500177.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics. 2006 May; 6(10):3075-86. Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D. PMID: 16619303.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Sci China C Life Sci. 2004 Jun; 47(3):219-23. Xiao X, Zhao X, Liu J, Guo F, Liu D, He D. PMID: 15524278.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Development of proteomic patterns for detecting lung cancer. Dis Markers. 2003-2004; 19(1):33-9. Xiao X, Liu D, Tang Y, Guo F, Xia L, Liu J, He D. PMID: 14757945; PMCID: PMC3851077.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
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