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Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 02 17; 379(6633):700-706.
Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE. PMID: 36795823; PMCID: PMC10108900.
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4 Fields:
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5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines. ACS Chem Neurosci. 2023 02 01; 14(3):351-358.
Cameron LP, Patel SD, Vargas MV, Barragan EV, Saeger HN, Warren HT, Chow WL, Gray JA, Olson DE. PMID: 36630260; PMCID: PMC9939288.
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2 Fields:
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HumansAnimals
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SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell Rep. 2022 12 20; 41(12):111842.
Wang Y, Zhang S, Lan Z, Doan V, Kim B, Liu S, Zhu M, Hull VL, Rihani S, Zhang CL, Gray JA, Guo F. PMID: 36543123; PMCID: PMC9875714.
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Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia. Neurobiol Dis. 2022 08; 170:105772.
Park DK, Petshow S, Anisimova M, Barragan EV, Gray JA, Stein IS, Zito K. PMID: 35605760; PMCID: PMC9352378.
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2 Fields:
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Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome. J Neurosci. 2021 10 20; 41(42):8801-8814.
Berg EL, Jami SA, Petkova SP, Berz A, Fenton TA, Lerch JP, Segal DJ, Gray JA, Ellegood J, Wöhr M, Silverman JL. PMID: 34475199; PMCID: PMC8528495.
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6 Fields:
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Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction. J Neurophysiol. 2021 07 01; 126(1):11-27.
Jami SA, Cameron S, Wong JM, Daly ER, McAllister AK, Gray JA. PMID: 34038186; PMCID: PMC8325603.
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5 Fields:
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AnimalsCells
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Basic and Clinical Pharmacology; Katzung BG (Ed.). Introduction to the Pharmacology of CNS Drugs. 2020; 381-394.
Gray JA.
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Postsynaptic Serine Racemase Regulates NMDA Receptor Function. J Neurosci. 2020 12 09; 40(50):9564-9575.
Wong JM, Folorunso OO, Barragan EV, Berciu C, Harvey TL, Coyle JT, Balu DT, Gray JA. PMID: 33158959; PMCID: PMC7726548.
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13 Fields:
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The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies. Neurosci Biobehav Rev. 2020 12; 119:217-241.
Li W, Kutas M, Gray JA, Hagerman RH, Olichney JM. PMID: 33039453.
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5 Fields:
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Humans
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019 07 09; 28(2):332-341.e5.
Chiu AM, Wang J, Fiske MP, Hubalkova P, Barse L, Gray JA, Sanz-Clemente A. PMID: 31291571; PMCID: PMC6639021.
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8 Fields:
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Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2019 03 01; 29(3):1217.
Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. PMID: 29474518; PMCID: PMC6373680.
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Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2019 02 01; 29(2):505-516.
Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. PMID: 29293918; PMCID: PMC6319175.
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5 Fields:
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AnimalsCells
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Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling. Sci Rep. 2018 11 30; 8(1):17522.
Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA. PMID: 30504838; PMCID: PMC6269523.
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13 Fields:
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Incomplete block of NMDA receptors by intracellular MK-801. Neuropharmacology. 2018 12; 143:122-129.
Sun W, Wong JM, Gray JA, Carter BC. PMID: 30227149; PMCID: PMC8920045.
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5 Fields:
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HumansAnimalsCells
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Psychedelics Promote Structural and Functional Neural Plasticity. Cell Rep. 2018 06 12; 23(11):3170-3182.
Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, Burbach KF, Soltanzadeh Zarandi S, Sood A, Paddy MR, Duim WC, Dennis MY, McAllister AK, Ori-McKenney KM, Gray JA, Olson DE. PMID: 29898390; PMCID: PMC6082376.
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211 Fields:
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Metaplasticity contributes to memory formation in the hippocampus. Neuropsychopharmacology. 2019 01; 44(2):408-414.
Crestani AP, Krueger JN, Barragan EV, Nakazawa Y, Nemes SE, Quillfeldt JA, Gray JA, Wiltgen BJ. PMID: 29849054; PMCID: PMC6300591.
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11 Fields:
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Long-Term Depression Is Independent of GluN2 Subunit Composition. J Neurosci. 2018 05 09; 38(19):4462-4470.
Wong JM, Gray JA. PMID: 29593052; PMCID: PMC5943974.
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16 Fields:
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AnimalsCells
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Basic and Clinical Pharmacology; Katzung BG (Ed.). Introduction to the Pharmacology of CNS Drugs. 2017; 367-380.
Gray JA.
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Kaplan & Sadock’s Comprehensive Textbook of Psychiatry; Sadock BJ, Sadock VA and Ruiz P (Eds.). Intraneuronal Signaling. 2017; 119-130.
Gray JA and Roth BL.
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Non-ionotropic signaling by the NMDA receptor: controversy and opportunity. F1000Res. 2016; 5.
Gray JA, Zito K, Hell JW. PMID: 27303637; PMCID: PMC4882754.
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9 Fields:
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Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage. J Neurosci. 2015 Sep 02; 35(35):12303-8.
Stein IS, Gray JA, Zito K. PMID: 26338340; PMCID: PMC4556794.
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62 Fields:
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AnimalsCells
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Basic and Clinical Pharmacology. Katzung BG (Ed.). Introduction to the Pharmacology of CNS Drugs. 2014; 355-368.
Gray JA and Nicoll RA .
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Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Cell Rep. 2013 Mar 28; 3(3):607-14.
Sanz-Clemente A, Gray JA, Ogilvie KA, Nicoll RA, Roche KW. PMID: 23478024; PMCID: PMC3615108.
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59 Fields:
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SAP102 mediates synaptic clearance of NMDA receptors. Cell Rep. 2012 Nov 29; 2(5):1120-8.
Chen BS, Gray JA, Sanz-Clemente A, Wei Z, Thomas EV, Nicoll RA, Roche KW. PMID: 23103165; PMCID: PMC3513525.
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40 Fields:
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Thinking outside the synapse: glycine at extrasynaptic NMDA receptors. Cell. 2012 Aug 03; 150(3):455-6.
Gray JA, Nicoll RA. PMID: 22863001.
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5 Fields:
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Parkinsonism and rabbit syndrome after discontinuation of low-dose ziprasidone and concomitant initiation of sertraline. J Clin Psychopharmacol. 2012 Feb; 32(1):142-3.
Gray JA. PMID: 22217953.
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Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron. 2011 Sep 22; 71(6):1085-101.
Gray JA, Shi Y, Usui H, During MJ, Sakimura K, Nicoll RA. PMID: 21943605; PMCID: PMC3183990.
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167 Fields:
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Genetic analysis of neuronal ionotropic glutamate receptor subunits. J Physiol. 2011 Sep 01; 589(17):4095-101.
Granger AJ, Gray JA, Lu W, Nicoll RA. PMID: 21768264; PMCID: PMC3180569.
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25 Fields:
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Cells
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Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit. J Neurophysiol. 2011 Feb; 105(2):923-8.
Lu W, Gray JA, Granger AJ, During MJ, Nicoll RA. PMID: 20980546; PMCID: PMC3059181.
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12 Fields:
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Metabolic control of vesicular glutamate transport and release. Neuron. 2010 Oct 06; 68(1):99-112.
Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y. PMID: 20920794; PMCID: PMC2978156.
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173 Fields:
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Kaplan & Sadock’s Comprehensive Textbook of Psychiatry; Sadock BJ, Sadock VA and Ruiz P (Eds.). Intraneuronal Signaling. 2009; 118-129.
Gray JA and Roth BL.
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The expanded biology of serotonin. Annu Rev Med. 2009; 60:355-66.
Berger M, Gray JA, Roth BL. PMID: 19630576; PMCID: PMC5864293.
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574 Fields:
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HumansAnimals
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The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct; 12(10):904-22.
Gray JA, Roth BL. PMID: 17667958.
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58 Fields:
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Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull. 2007 Sep; 33(5):1100-19.
Gray JA, Roth BL. PMID: 17617664; PMCID: PMC2632344.
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79 Fields:
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Handbook of Contemporary Neuropharmacology. Sibley DR, Hanin I, Kuhar M and Skolnick P (Eds.). Serotonin Systems. 2007; 257-298.
Gray JA and Roth BL.
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Developing selectively nonselective drugs for treating CNS disorders. Drug Discovery Today Therapeutic Strategies. 2006 Dec 1; 3(4):413-419.
Gray GJ, Roth RB. .
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Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization. Biochemistry. 2003 Sep 16; 42(36):10853-62.
Gray JA, Compton-Toth BA, Roth BL. PMID: 12962510.
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15 Fields:
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HumansAnimalsCells
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The interaction of a constitutively active arrestin with the arrestin-insensitive 5-HT(2A) receptor induces agonist-independent internalization. Mol Pharmacol. 2003 May; 63(5):961-72.
Gray JA, Bhatnagar A, Gurevich VV, Roth BL. PMID: 12695524.
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22 Fields:
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A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem. 2003 Jun 13; 278(24):21901-8.
Xia Z, Gray JA, Compton-Toth BA, Roth BL. PMID: 12682061.
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58 Fields:
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HumansCells
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The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro. Neuroscience. 2003; 122(4):907-20.
Xia Z, Hufeisen SJ, Gray JA, Roth BL. PMID: 14643760.
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29 Fields:
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HumansAnimalsCells
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Cell biology. A last GASP for GPCRs? Science. 2002 Jul 26; 297(5581):529-31.
Gray JA, Roth BL. PMID: 12142517.
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5 Fields:
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HumansCells
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Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists. Brain Res Bull. 2001 Nov 15; 56(5):441-51.
Gray JA, Roth BL. PMID: 11750789.
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95 Fields:
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HumansAnimalsCells
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Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol Pharmacol. 2001 Nov; 60(5):1020-30.
Gray JA, Sheffler DJ, Bhatnagar A, Woods JA, Hufeisen SJ, Benovic JL, Roth BL. PMID: 11641430.
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27 Fields:
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HumansAnimalsCells
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The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem. 2001 Mar 16; 276(11):8269-77.
Bhatnagar A, Willins DL, Gray JA, Woods J, Benovic JL, Roth BL. PMID: 11069907.
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36 Fields:
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HumansAnimals
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Structure and function of the third intracellular loop of the 5-hydroxytryptamine2A receptor: the third intracellular loop is alpha-helical and binds purified arrestins. J Neurochem. 1999 May; 72(5):2206-14.
Gelber EI, Kroeze WK, Willins DL, Gray JA, Sinar CA, Hyde EG, Gurevich V, Benovic J, Roth BL. PMID: 10217304.
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26 Fields:
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AnimalsCells