Lin Tian

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Title(s)	Adjunct Professor, Biochemistry and Molecular Medicine
School	School of Medicine
Address	4453 Tupper Hall CA 95616
Phone	530-752-8667
vCard	Download vCard

Research

research activities and funding

State-dependent control of nociception in opioid circuits
NIH R01NS140454Aug 1, 2025 - Jun 30, 2030
Role: Co-Principal Investigator

Magnetogenetic control of vulnerable brain cell types in Alzheimer's disease
NIH R61AG094651Aug 1, 2025 - Jul 31, 2027
Role: Co-Principal Investigator

Optimization of genetically encoded voltage and neurotransmitter indicators for multiwavelength in vivo analysis of brain circuits
NIH UM1MH136462Jul 1, 2024 - Jan 31, 2029
Role: Principal Investigator

Genetically-Encoded, Non-Invasive and Wireless Modulation of Calcium Dynamics in Astrocytes With Spatiotemporal Precision and Depth
NIH R01NS129888Feb 1, 2023 - Jan 31, 2028
Role: Co-Principal Investigator

Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species
NIH UF1MH128336Sep 20, 2021 - Sep 19, 2024
Role: Co-Principal Investigator

Astrocyte Modulation of Neural Circuit Function and Behavior
NIH U19NS123719Aug 15, 2021 - Jul 31, 2026
Role: Co-Principal Investigator

Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution
NIH U01NS120820May 1, 2021 - Jul 31, 2025
Role: Principal Investigator

Development of multi-color, bright chemigenetic indicators to image synaptic transmission
NIH R21EY031858Sep 1, 2020 - Jun 30, 2022
Role: Principal Investigator

Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuits
NIH U01NS113295Aug 15, 2019 - May 31, 2023
Role: Co-Principal Investigator

Differentiation and Integration of Trisomy 21 iPSCs in an Animal Model
NIH R01HD091325Aug 1, 2017 - Apr 30, 2022
Role: Principal Investigator

Genetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animals
NIH U01NS103522Aug 1, 2017 - Jun 30, 2021
Role: Principal Investigator

Large-scale analysis of functional synapses during circuit plasticity with novel optogenetic sensors
NIH U01NS103571Jun 1, 2017 - May 31, 2021
Role: Co-Principal Investigator

Microsystems for Modeling Neurodevelopmental Disorders
NIH R21NS095325Apr 1, 2016 - Mar 31, 2019
Role: Principal Investigator

Genetically encoded sensors for the biogenic amines: watching neuromodulation in action
NIH U01NS090604Sep 30, 2014 - Jul 31, 2018
Role: Principal Investigator

Fluorescent biosensors for imaging neurotransmitters: observing synapses in actio
NIH DP2MH107056Sep 19, 2014 - May 31, 2019
Role: Principal Investigator

Bibliographic

publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Vesicular Glutamate Release Is Necessary for Neural Tube Formation. J Neurosci. 2026 Mar 18; 46(11). Goyal R, Castro PA, Levin JB, Shim S, Balashova OA, Panoutsopoulos AA, Fuentes NA, Or Mizuno G, Tian L, Borodinsky LN. PMID: 41708332; PMCID: PMC12988593.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Comparison of simulated gastrointestinal digestion platforms with varying complexity and sample mass requirements, using common bean (Phaseolus vulgaris L.) as a model. J Sci Food Agric. 2026 Mar 15; 106(4):2065-2081. Bolt TM, Riggs M, Sun W, Yu S, Lerno L, Tian L, Gepts P, Palkovic A, Parker TA, Bornhorst GM, Diepenbrock CH. PMID: 41251189; PMCID: PMC12872248.

View in: PubMed Mentions: Fields:
Nut Nutritional Sciences
Translation:Humans Animals
Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum. Neuron. 2025 Dec 03; 113(23):4055-4068.e8. Kamath T, Lodder B, Bilsel E, Green I, Dalangin R, Raghubardayal M, Wang W, Capelli P, Legister J, Timmins J, Hulshof L, Wallace JB, Tian L, Uchida N, Watabe-Uchida M, Sabatini BL. PMID: 41043421; PMCID: PMC12712896.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals Cells
Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution. Neuron. 2025 Nov 05; 113(21):3554-3566.e7. Lodder B, Kamath T, Savenco E, Röring B, Siegel M, Chouinard JA, Lee SJ, Zagoren C, Rosen P, Hartman I, Timmins J, Adan R, Tian L, Sabatini BL. PMID: 40939592; PMCID: PMC12509219.

View in: PubMed Mentions: 6 Fields:
Neu Neurology
Translation:Animals Cells
Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit. Neuron. 2025 Jun 04; 113(11):1823-1840.e8. Sun Q, Liu M, Guan W, Xiao X, Dong C, Bruchas MR, Zweifel LS, Li Y, Tian L, Li B. PMID: 40239651; PMCID: PMC12640778.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals Cells
Meningeal regulatory T cells inhibit nociception in female mice. Science. 2025 04 04; 388(6742):96-104. Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Tian L, Domingos AI, Pintar JE, Basbaum AI, Kashem SW. PMID: 40179196; PMCID: PMC13222563.

View in: PubMed Mentions: 12 Fields:
Sci Science
Translation:Animals Cells
Changes in neurotensin signalling drive hedonic devaluation in obesity. Nature. 2025 05; 641(8065):1238-1247. Gazit Shimoni N, Tose AJ, Seng C, Jin Y, Lukacsovich T, Yang H, Verharen JPH, Liu C, Tanios M, Hu E, Read J, Tang LW, Lim BK, Tian L, Földy C, Lammel S. PMID: 40140571; PMCID: PMC12119351.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Animals Cells
Thalamic opioids from POMC satiety neurons switch on sugar appetite. Science. 2025 01 02; 387(6735):750-758. Minère M, Wilhelms H, Kuzmanovic B, Lundh S, Fusca D, Claßen A, Shtiglitz S, Prilutski Y, Talpir I, Tian L, Kieffer B, Davis J, Kloppenburg P, Tittgemeyer M, Livneh Y, Fenselau H. PMID: 39946455.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Humans Animals Cells
On the Power of Constructive Criticism. Neurophotonics. 2024 Oct; 11(4):040101. PMID: 39713177; PMCID: PMC11661393.

View in: PubMed Mentions:
Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states. Science. 2024 11 15; 386(6723):802-810. Muir J, Lin S, Aarrestad IK, Daniels HR, Ma J, Tian L, Olson DE, Kim CK. PMID: 39541450; PMCID: PMC11588385.

View in: PubMed Mentions: 17 Fields:
Sci Science
Translation:Animals Cells
Stochastic neuropeptide signals compete to calibrate the rate of satiation. Nature. 2025 01; 637(8044):137-144. Zhang SX, Kim A, Madara JC, Zhu PK, Christenson LF, Lutas A, Kalugin PN, Sunkavalli PS, Jin Y, Pal A, Tian L, Lowell BB, Andermann ML. PMID: 39506113; PMCID: PMC11981016.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals Cells
Editorial: Proanthocyanidins and isoflavonoids. Front Plant Sci. 2024; 15:1498989. Tian L, Xie D. PMID: 39416479; PMCID: PMC11480007.

View in: PubMed Mentions:
Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice. Appetite. 2024 12 01; 203:107673. Wu CT, Gonzalez Magaña D, Roshgadol J, Tian L, Ryan KK. PMID: 39260700.

View in: PubMed Mentions: 3 Fields:
Beh Behavioral Sciences Nut Nutritional Sciences
Translation:Animals Cells
What tool or method do you wish existed? Cell. 2024 Aug 22; 187(17):4433-4438. Chen YY, Evavold CL, Mann M, Davenport ER, McFall-Ngai M, Bienko M, Ueda HR, Tian L, Tjahjono N, Anikeeva P, Liu JG, Deans TL, Shen X. PMID: 39178826.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology
Seed color patterns in domesticated common bean are regulated by MYB-bHLH-WD40 transcription factors and temperature. Plant J. 2024 Sep; 119(6):2765-2781. Parker T, Bolt T, Williams T, Penmetsa RV, Mulube M, Celebioglu B, Palkovic A, Jochua CN, Del Mar Rubio Wilhelmi M, Lo S, Bornhorst G, Tian L, Kamfwa K, Farmer A, Diepenbrock C, Gepts P. PMID: 39152711.

View in: PubMed Mentions: 7 Fields:
Bot Botany Cel Cell Biology Mol Molecular Biology
Translation:Animals
Editorial: Building climate resilient deciduous tree crops by deciphering winter dormancy. Front Plant Sci. 2024; 15:1463405. Yu S, Wenden B, Ferguson L, Tian L. . PMID: 39129762; PMCID: PMC11310153.

View in: PubMed Mentions:
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Nat Neurosci. 2024 Sep; 27(9):1844-1857. Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR, Banghart MR, Tian L. PMID: 39009835; PMCID: PMC11374718.

View in: PubMed Mentions: 25 Fields:
Neu Neurology
Translation:Humans Animals Cells
Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research. Neuropsychopharmacology. 2024 11; 50(1):269-273. Wright EC, Scott E, Tian L. PMID: 38942957; PMCID: PMC11525779.

View in: PubMed Mentions: 4 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Humans Animals
Distinct growth patterns in seedling and tillering wheat plants suggests a developmentally restricted role of HYD2 in salt-stress response. Plant Cell Rep. 2024 Apr 17; 43(5):119. Bekkering C, Yu S, Kuo CC, Tian L. . PMID: 38632145; PMCID: PMC11024023.

View in: PubMed Mentions: 1 Fields:
Bot Botany
Translation:Animals
Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states. Neuron. 2024 06 19; 112(12):2062-2078.e7. Wang H, Flores RJ, Yarur HE, Limoges A, Bravo-Rivera H, Casello SM, Loomba N, Enriquez-Traba J, Arenivar M, Wang Q, Ganley R, Ramakrishnan C, Fenno LE, Kim Y, Deisseroth K, Or G, Dong C, Hoon MA, Tian L, Tejeda HA. PMID: 38614102; PMCID: PMC11250624.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Animals Cells
Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus. Elife. 2024 Apr 09; 12. Wilmot JH, Diniz CRAF, Crestani AP, Puhger KR, Roshgadol J, Tian L, Wiltgen BJ. PMID: 38592773; PMCID: PMC11003744.

View in: PubMed Mentions: 17 Fields:
Bio Biology
Translation:Animals
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior. Neuron. 2024 03 20; 112(6):909-923.e9. Vu MT, Brown EH, Wen MJ, Noggle CA, Zhang Z, Monk KJ, Bouabid S, Mroz L, Graham BM, Zhuo Y, Li Y, Otchy TM, Tian L, Davison IG, Boas DA, Howe MW. PMID: 38242115; PMCID: PMC10957316.

View in: PubMed Mentions: 15 Fields:
Neu Neurology
Translation:Animals
Sexual differentiation of neural mechanisms of stress sensitivity during puberty. Proc Natl Acad Sci U S A. 2023 10 24; 120(43):e2306475120. Wright EC, Luo PX, Zakharenkov HC, Serna Godoy A, Lake AA, Prince ZD, Sekar S, Culkin HI, Ramirez AV, Dwyer T, Kapoor A, Corbett C, Tian L, Fox AS, Trainor BC. PMID: 37847733; PMCID: PMC10614610.

View in: PubMed Mentions: 19 Fields:
Sci Science
Translation:Humans
Temporal transcriptome and metabolite analyses provide insights into the biochemical and physiological processes underlying endodormancy release in pistachio (Pistacia vera L.) flower buds. Front Plant Sci. 2023; 14:1240442. Yu S, Amaral D, Brown PH, Ferguson L, Tian L. . PMID: 37810399; PMCID: PMC10556704.

View in: PubMed Mentions: 1
From plastids to the cytosol: Redefining boundaries for provitamin A biofortification in plants. Mol Plant. 2023 07 03; 16(7):1109-1112. Yu S, Bekkering CS, Tian L. . PMID: 37403360.

View in: PubMed Mentions: Fields:
Bot Botany Mol Molecular Biology
Translation:Cells
Lighting up action potentials with fast and bright voltage sensors. Nat Methods. 2023 07; 20(7):990-992. Andreoni A, Tian L. PMID: 37429963.

View in: PubMed Mentions: 4 Fields:
Cli Clinical Laboratory Techniques
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 02 17; 379(6633):700-706. Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE. PMID: 36795823; PMCID: PMC10108900.

View in: PubMed Mentions: 179 Fields:
Sci Science
Translation:Animals Cells
Genetic dissection of the roles of β-hydroxylases in carotenoid metabolism, photosynthesis, and plant growth in tetraploid wheat (Triticum turgidum L.). Theor Appl Genet. 2023 Jan; 136(1):8. Bekkering CS, Yu S, Isaka NN, Sproul BW, Dubcovsky J, Tian L. . PMID: 36656368; PMCID: PMC9852137.

View in: PubMed Mentions: 1 Fields:
Gen Genetics
Translation:Animals Cells
Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors. Annu Rev Neurosci. 2022 07 08; 45:273-294. Dong C, Zheng Y, Long-Iyer K, Wright EC, Li Y, Tian L. PMID: 35316611; PMCID: PMC9940643.

View in: PubMed Mentions: 47 Fields:
Neu Neurology
Translation:Animals Cells
Mutational Analysis of a Wheat O-methyltransferase Involved in Flavonoid Metabolism. Plants (Basel). 2022 Jan 08; 11(2). Cain AB, Yu S, Tian L. . PMID: 35050052; PMCID: PMC8780298.

View in: PubMed Mentions: 2
Letting the little light of mind shine: Advances and future directions in neurochemical detection. Neurosci Res. 2022 Jun; 179:65-78. Tjahjono N, Jin Y, Hsu A, Roukes M, Tian L. PMID: 34861294; PMCID: PMC9508992.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Cells
Mutant combinations of lycopene ɛ-cyclase and β-carotene hydroxylase 2 homoeologs increased β-carotene accumulation in endosperm of tetraploid wheat (Triticum turgidum L.) grains. Plant Biotechnol J. 2022 03; 20(3):564-576. Yu S, Li M, Dubcovsky J, Tian L. . PMID: 34695292; PMCID: PMC8882798.

View in: PubMed Mentions: 13 Fields:
Bio Biotechnology Bot Botany
Translation:Animals
Assessing the Role of Carotenoid Cleavage Dioxygenase 4 Homoeologs in Carotenoid Accumulation and Plant Growth in Tetraploid Wheat. Front Nutr. 2021; 8:740286. Yu S, Tian L. . PMID: 34568408; PMCID: PMC8455956.

View in: PubMed Mentions: 2
Metabolic engineering in woody plants: challenges, advances, and opportunities. aBIOTECH. 2021 Sep; 2(3):299-313. Yu S, Bekkering CS, Tian L. . PMID: 36303882; PMCID: PMC9590576.

View in: PubMed Mentions:
Psychedelic-inspired drug discovery using an engineered biosensor. Cell. 2021 05 13; 184(10):2779-2792.e18. Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L. PMID: 33915107; PMCID: PMC8122087.

View in: PubMed Mentions: 106 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Flavonoids in Cannabis sativa: Biosynthesis, Bioactivities, and Biotechnology. ACS Omega. 2021 Mar 02; 6(8):5119-5123. Bautista JL, Yu S, Tian L. . PMID: 33681553; PMCID: PMC7931196.

View in: PubMed Mentions: 60
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020 12 23; 183(7):1986-2002.e26. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. PMID: 33333022; PMCID: PMC8025677.

View in: PubMed Mentions: 97 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators. Neuron. 2020 10 14; 108(1):17-32. Sabatini BL, Tian L. PMID: 33058762.

View in: PubMed Mentions: 121 Fields:
Neu Neurology
Translation:Humans Animals Cells
An expanded palette of dopamine sensors for multiplex imaging in vivo. Nat Methods. 2020 11; 17(11):1147-1155. Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L. PMID: 32895537; PMCID: PMC8169200.

View in: PubMed Mentions: 118 Fields:
Cli Clinical Laboratory Techniques
Translation:Humans Animals Cells
Imaging voltage and brain chemistry with genetically encoded sensors and modulators. Curr Opin Chem Biol. 2020 08; 57:166-176. Pal A, Tian L. PMID: 32823064.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9. Nat Commun. 2020 03 04; 11(1):1178. Dong OX, Yu S, Jain R, Zhang N, Duong PQ, Butler C, Li Y, Lipzen A, Martin JA, Barry KW, Schmutz J, Tian L, Ronald PC. PMID: 32132530; PMCID: PMC7055238.

View in: PubMed Mentions: 105 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 Feb; 23(2):293. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31911656; PMCID: PMC7333455.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Thinking Outside of the Cereal Box: Breeding Underutilized (Pseudo)Cereals for Improved Human Nutrition. Front Genet. 2019; 10:1289. Bekkering CS, Tian L. . PMID: 31921317; PMCID: PMC6933008.

View in: PubMed Mentions: 15
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 01; 23(1):15-20. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31844313; PMCID: PMC7257994.

View in: PubMed Mentions: 84 Fields:
Neu Neurology
Translation:Humans Animals Cells
Measuring brain chemistry with genetically encoded fluorescent sensors. Current Opinion in Biomedical Engineering. 2019 Dec 1; 12:59-67. Andreoni AA, Davis DC, Tian TL. .

View in: Publisher Site Mentions:
Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators. Nat Protoc. 2019 12; 14(12):3471-3505. Patriarchi T, Cho JR, Merten K, Marley A, Broussard GJ, Liang R, Williams J, Nimmerjahn A, von Zastrow M, Gradinaru V, Tian L. PMID: 31732722.

View in: PubMed Mentions: 30 Fields:
Cli Clinical Laboratory Techniques Sci Science
Translation:Humans Animals Cells
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Front Cell Neurosci. 2019; 13:499. Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA. PMID: 31798415; PMCID: PMC6874132.

View in: PubMed Mentions: 12
Phylogenomic analysis of UDP-dependent glycosyltransferases provides insights into the evolutionary landscape of glycosylation in plant metabolism. Plant J. 2019 12; 100(6):1273-1288. Wilson AE, Tian L. . PMID: 31446648.

View in: PubMed Mentions: 48 Fields:
Bot Botany Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. Elife. 2019 09 23; 8. Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V. PMID: 31545171; PMCID: PMC6819083.

View in: PubMed Mentions: 23 Fields:
Bio Biology
Translation:Animals Cells
Publisher Correction: Dissociable dopamine dynamics for learning and motivation. Nature. 2019 Jul; 571(7763):E3. Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD. PMID: 31217588.

View in: PubMed Mentions: 5 Fields:
Sci Science
Temporally and Spatially Distinct Thirst Satiation Signals. Neuron. 2019 07 17; 103(2):242-249.e4. Augustine V, Ebisu H, Zhao Y, Lee S, Ho B, Mizuno GO, Tian L, Oka Y. PMID: 31153646; PMCID: PMC7335596.

View in: PubMed Mentions: 46 Fields:
Neu Neurology
Translation:Animals Cells
Dissociable dopamine dynamics for learning and motivation. Nature. 2019 06; 570(7759):65-70. Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD. PMID: 31118513; PMCID: PMC6555489.

View in: PubMed Mentions: 341 Fields:
Sci Science
Translation:Animals Cells
Maps of neuronal activity across the mouse brain. Nat Biomed Eng. 2019 05; 3(5):335-336. Andreoni A, Tian L. PMID: 31073176.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering
Translation:Animals Cells
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. Neuron. 2019 01 02; 101(1):133-151.e7. de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S. PMID: 30503173; PMCID: PMC6317997.

View in: PubMed Mentions: 271 Fields:
Neu Neurology
Translation:Animals Cells
PgUGT95B2 preferentially metabolizes flavones/flavonols and has evolved independently from flavone/flavonol UGTs identified in Arabidopsis thaliana. Phytochemistry. 2019 Jan; 157:184-193. Wilson AE, Wu S, Tian L. . PMID: 30419412.

View in: PubMed Mentions: 16 Fields:
Bot Botany Che Chemistry
Translation:Animals Cells
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. Elife. 2018 10 30; 7. Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C. PMID: 30373717; PMCID: PMC6207421.

View in: PubMed Mentions: 103 Fields:
Bio Biology
Translation:Humans Animals Cells
Distinctive Patterns of Flavonoid Biosynthesis in Roots and Nodules of Datisca glomerata and Medicago spp. Revealed by Metabolomic and Gene Expression Profiles. Front Plant Sci. 2018; 9:1463. Gifford I, Battenberg K, Vaniya A, Wilson A, Tian L, Fiehn O, Berry AM. PMID: 30364174; PMCID: PMC6192435.

View in: PubMed Mentions: 15
In vivo measurement of afferent activity with axon-specific calcium imaging. Nat Neurosci. 2018 09; 21(9):1272-1280. Broussard GJ, Liang Y, Fridman M, Unger EK, Meng G, Xiao X, Ji N, Petreanu L, Tian L. PMID: 30127424; PMCID: PMC6697169.

View in: PubMed Mentions: 121 Fields:
Neu Neurology
Translation:Animals Cells
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Rep. 2018 07 10; 24(2):355-365. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. PMID: 29996097; PMCID: PMC6631348.

View in: PubMed Mentions: 36 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science. 2018 06 29; 360(6396). Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L. PMID: 29853555; PMCID: PMC6287765.

View in: PubMed Mentions: 535 Fields:
Sci Science
Translation:Humans Animals Cells
Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Xiang YK, Coleman MA, Tian L. PMID: 29476125; PMCID: PMC5824837.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Cells
Cloning and functional characterization of a p-coumaroyl quinate/shikimate 3'-hydroxylase from potato (Solanum tuberosum). Biochem Biophys Res Commun. 2018 02 05; 496(2):462-467. Knollenberg BJ, Liu J, Yu S, Lin H, Tian L. . PMID: 29337064.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals Cells
Imaging Glutamate with Genetically Encoded Fluorescent Sensors. . 2018 Jan 1; 130:117-153. Broussard BG, Unger UE, Liang LR, McGrew MB, Tian TL. .

View in: Publisher Site Mentions:
Characterization of a UGT84 Family Glycosyltransferase Provides New Insights into Substrate Binding and Reactivity of Galloylglucose Ester-Forming UGTs. Biochemistry. 2017 Dec 05; 56(48):6389-6400. Wilson AE, Feng X, Ono NN, Holland D, Amir R, Tian L. . PMID: 29140084.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Animals Cells
Breeding Major Cereal Grains through the Lens of Nutrition Sensitivity. Mol Plant. 2018 01 08; 11(1):23-30. Yu S, Tian L. . PMID: 28827167.

View in: PubMed Mentions: 26 Fields:
Bot Botany Mol Molecular Biology
Translation:Animals
Automated Functional Analysis of Astrocytes from Chronic Time-Lapse Calcium Imaging Data. Front Neuroinform. 2017; 11:48. Wang Y, Shi G, Miller DJ, Wang Y, Wang C, Broussard G, Wang Y, Tian L, Yu G. PMID: 28769780; PMCID: PMC5509822.

View in: PubMed Mentions: 5
Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides. ACS Comb Sci. 2017 05 08; 19(5):299-307. Carney RP, Thillier Y, Kiss Z, Sahabi A, Heleno Campos JC, Knudson A, Liu R, Olivos D, Saunders M, Tian L, Lam KS. PMID: 28378995; PMCID: PMC5901688.

View in: PubMed Mentions: 12 Fields:
Che Chemistry
Translation:Humans Cells
Advancing Human Health through Exploration of Plant Metabolism and Reaping the Benefits of Edible Medicinal Plants. Mol Plant. 2017 03 06; 10(3):533-536. Tian L, Hu Y, Chen XY. PMID: 28153709.

View in: PubMed Mentions: 2 Fields:
Bot Botany Mol Molecular Biology
Translation:Humans Animals
Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Rep. 2016 09 27; 17(1):165-178. Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. PMID: 27681429; PMCID: PMC5076887.

View in: PubMed Mentions: 90 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Distinct expression and function of carotenoid metabolic genes and homoeologs in developing wheat grains. BMC Plant Biol. 2016 07 12; 16(1):155. Qin X, Fischer K, Yu S, Dubcovsky J, Tian L. . PMID: 27405473; PMCID: PMC4943016.

View in: PubMed Mentions: 21 Fields:
Bot Botany
Translation:Animals
Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum). PLoS One. 2016; 11(5):e0156319. Ono NN, Qin X, Wilson AE, Li G, Tian L. . PMID: 27227328; PMCID: PMC4882073.

View in: PubMed Mentions: 25 Fields:
Med Medicine (General)Sci Science
Translation:Animals
FASP: A Machine Learning Approach to Functional Astrocyte Phenotyping from Time-Lapse Calcium Imaging Data. . 2016 Apr 1; 351-354. Wang WY, Shi SG, Miller MD, Wang WY, Broussard BG, Wang WY, Tian TL, Yu YG. .

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Erratum: Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst Nanoeng. 2016; 2:16014. Gao Y, Broussard J, Haque A, Revzin A, Tian L. PMID: 31063160; PMCID: PMC6444724.

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Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst Nanoeng. 2016; 2:15045. Gao Y, Broussard J, Haque A, Revzin A, Lin T. PMID: 31057811; PMCID: PMC6444726.

View in: PubMed Mentions: 17
CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. Cell Rep. 2015 Dec 15; 13(10):2056-63. Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ. PMID: 26670043; PMCID: PMC4684969.

View in: PubMed Mentions: 54 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Recent advances in understanding carotenoid-derived signaling molecules in regulating plant growth and development. Front Plant Sci. 2015; 6:790. Tian L. . PMID: 26442092; PMCID: PMC4585149.

View in: PubMed Mentions: 23
Imaging chemical neurotransmission with genetically encoded fluorescent sensors. ACS Chem Neurosci. 2015 Jan 21; 6(1):84-93. Liang R, Broussard GJ, Tian L. PMID: 25565280.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Humans Animals
Using Hairy Roots for Production of Valuable Plant Secondary Metabolites. Adv Biochem Eng Biotechnol. 2015; 149:275-324. Tian L. . PMID: 25583225.

View in: PubMed Mentions: 16 Fields:
Bio Biochemistry Bio Biotechnology
Translation:Animals Cells
Monitoring activity in neural circuits with genetically encoded indicators. Front Mol Neurosci. 2014; 7:97. Broussard GJ, Liang R, Tian L. PMID: 25538558; PMCID: PMC4256991.

View in: PubMed Mentions: 70
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Front Mol Neurosci. 2013; 6:2. Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL. PMID: 23459413; PMCID: PMC3586699.

View in: PubMed Mentions: 399
An optimized fluorescent probe for visualizing glutamate neurotransmission. Nat Methods. 2013 Feb; 10(2):162-70. Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL. PMID: 23314171; PMCID: PMC4469972.

View in: PubMed Mentions: 531 Fields:
Cli Clinical Laboratory Techniques
Translation:Animals Cells
Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci. 2012 Oct 03; 32(40):13819-40. Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL. PMID: 23035093; PMCID: PMC3482105.

View in: PubMed Mentions: 707 Fields:
Neu Neurology
Translation:Humans Animals Cells
Cloning and comparative analysis of carotenoid β-hydroxylase genes provides new insights into carotenoid metabolism in tetraploid (Triticum turgidum ssp. durum) and hexaploid (Triticum aestivum) wheat grains. Plant Mol Biol. 2012 Dec; 80(6):631-46. Qin X, Zhang W, Dubcovsky J, Tian L. . PMID: 23015203; PMCID: PMC4783145.

View in: PubMed Mentions: 22 Fields:
Bot Botany Mol Molecular Biology
Translation:Humans Animals PHPublic Health
Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature. 2012 Sep 13; 489(7415):299-303. Petreanu L, Gutnisky DA, Huber D, Xu NL, O'Connor DH, Tian L, Looger L, Svoboda K. PMID: 22922646; PMCID: PMC3443316.

View in: PubMed Mentions: 198 Fields:
Sci Science
Translation:Animals Cells
Establishment of pomegranate (Punica granatum) hairy root cultures for genetic interrogation of the hydrolyzable tannin biosynthetic pathway. Planta. 2012 Sep; 236(3):931-41. Ono NN, Bandaranayake PC, Tian L. . PMID: 22810948.

View in: PubMed Mentions: 15 Fields:
Bot Botany
Translation:Animals Cells
Imaging neuronal activity with genetically encoded calcium indicators. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):647-56. Tian L, Hires SA, Looger LL. PMID: 22661439.

View in: PubMed Mentions: 81 Fields:
Cli Clinical Laboratory Techniques
Translation:Cells
Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature. 2012 Apr 25; 484(7395):473-8. Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K. PMID: 22538608; PMCID: PMC4601999.

View in: PubMed Mentions: 301 Fields:
Sci Science
Translation:Animals
Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4756-61. Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD. PMID: 22411832; PMCID: PMC3323987.

View in: PubMed Mentions: 83 Fields:
Sci Science
Translation:Humans Animals Cells
A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci. 2012 Feb 29; 32(9):3131-41. Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW. PMID: 22378886; PMCID: PMC3315707.

View in: PubMed Mentions: 241 Fields:
Neu Neurology
Translation:Humans Animals Cells
Neural activity imaging with genetically encoded calcium indicators. Prog Brain Res. 2012; 196:79-94. Tian L, Akerboom J, Schreiter ER, Looger LL. PMID: 22341322.

View in: PubMed Mentions: 34 Fields:
Bra Brain
Translation:Animals Cells
Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery(F). J Integr Plant Biol. 2011 Oct; 53(10):800-13. Ono NN, Britton MT, Fass JN, Nicolet CM, Lin D, Tian L. . PMID: 21910825.

View in: PubMed Mentions: 22 Fields:
Bot Botany
Translation:Animals Cells
Expression, subcellular localization, and cis-regulatory structure of duplicated phytoene synthase genes in melon (Cucumis melo L.). Planta. 2011 Oct; 234(4):737-48. Qin X, Coku A, Inoue K, Tian L. . PMID: 21626149.

View in: PubMed Mentions: 23 Fields:
Bot Botany
Translation:Animals Cells
Copigmentation triggers the development of skin burning disorder on peach and nectarine fruit [Prunus persica (L.) Batsch]. J Agric Food Chem. 2011 Mar 23; 59(6):2393-402. Cantín CM, Tian L, Qin X, Crisosto CH. PMID: 21361290.

View in: PubMed Mentions: 1 Fields:
Che Chemistry Nut Nutritional Sciences
Translation:Animals
Imaging light responses of targeted neuron populations in the rodent retina. J Neurosci. 2011 Feb 23; 31(8):2855-67. Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL. PMID: 21414907; PMCID: PMC3521507.

View in: PubMed Mentions: 59 Fields:
Neu Neurology
Translation:Animals Cells
The multiplicity of hairy root cultures: prolific possibilities. Plant Sci. 2011 Mar; 180(3):439-46. Ono NN, Tian L. . PMID: 21421390.

View in: PubMed Mentions: 52 Fields:
Bot Botany
Translation:Humans Animals Cells
Toward the second generation of optogenetic tools. J Neurosci. 2010 Nov 10; 30(45):14998-5004. Knöpfel T, Lin MZ, Levskaya A, Tian L, Lin JY, Boyden ES. PMID: 21068304; PMCID: PMC2997431.

View in: PubMed Mentions: 51 Fields:
Neu Neurology
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nat Neurosci. 2010 Nov; 13(11):1433-40. Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW. PMID: 20890294; PMCID: PMC2967725.

View in: PubMed Mentions: 441 Fields:
Neu Neurology
Translation:Animals Cells
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods. 2009 Dec; 6(12):875-81. Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL. PMID: 19898485; PMCID: PMC2858873.

View in: PubMed Mentions: 1148 Fields:
Cli Clinical Laboratory Techniques
Translation:Humans Animals Cells
Antibacterial activity of phenolic compounds against the phytopathogen Xylella fastidiosa. Curr Microbiol. 2010 Jan; 60(1):53-8. Maddox CE, Laur LM, Tian L. . PMID: 19813054; PMCID: PMC2796966.

View in: PubMed Mentions: 88 Fields:
Mic Microbiology
Translation:Animals Cells
Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. BMC Plant Biol. 2009 Jan 05; 9:1. Tian L, Peel GJ, Lei Z, Aziz N, Dai X, He J, Watson B, Zhao PX, Sumner LW, Dixon RA. PMID: 19123941; PMCID: PMC2630931.

View in: PubMed Mentions: 20 Fields:
Bot Botany
Translation:Animals Cells
Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design. J Biol Chem. 2009 Mar 06; 284(10):6455-64. Akerboom J, Rivera JD, Guilbe MM, Malavé EC, Hernandez HH, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER. PMID: 19098007; PMCID: PMC2649101.

View in: PubMed Mentions: 141 Fields:
Bio Biochemistry
Translation:Animals Cells
Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biol. 2008 Aug; 36(1-4):69-86. Hires SA, Tian L, Looger LL. PMID: 18941901; PMCID: PMC2755531.

View in: PubMed Mentions: 69 Fields:
Bra Brain Cel Cell Biology
Translation:Animals Cells
Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems. Drug Discov Today Dis Models. 2008; 5(1):27-35. Tian L, Looger LL. PMID: 19461949; PMCID: PMC2651031.

View in: PubMed Mentions: 7
Erratum: Where to start and when to stop. Nature Structural & Molecular Biology. 2006 Sep 1; 13(9):855-855. Tian TL, Matouschek MA. .

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Where to start and when to stop. Nat Struct Mol Biol. 2006 Aug; 13(8):668-70. Tian L, Matouschek A. PMID: 16886005.

View in: PubMed Mentions: 4 Fields:
Mol Molecular Biology
Translation:Animals Cells
A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB. Nat Struct Mol Biol. 2005 Dec; 12(12):1045-53. Tian L, Holmgren RA, Matouschek A. PMID: 16299518.

View in: PubMed Mentions: 72 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
An unstructured initiation site is required for efficient proteasome-mediated degradation. Nat Struct Mol Biol. 2004 Sep; 11(9):830-7. Prakash S, Tian L, Ratliff KS, Lehotzky RE, Matouschek A. PMID: 15311270.

View in: PubMed Mentions: 251 Fields:
Mol Molecular Biology
Translation:Animals Cells