Lin Tian

Title(s)Associate Professor, Biochemistry and Molecular Medicine
SchoolSchool of Medicine
Address4453 Tupper Hall
CA 95616
Phone530-752-8667
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    Collapse Research 
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    Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across Species
    NIH UF1MH128336Sep 20, 2021 - Sep 19, 2024
    Role: Co-Principal Investigator
    Astrocyte Modulation of Neural Circuit Function and Behavior
    NIH U19NS123719Aug 15, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolution
    NIH U01NS120820May 1, 2021 - Apr 30, 2025
    Role: Principal Investigator
    Development of multi-color, bright chemigenetic indicators to image synaptic transmission
    NIH R21EY031858Sep 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuits
    NIH U01NS113295Aug 15, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Differentiation and Integration of Trisomy 21 iPSCs in an Animal Model
    NIH R01HD091325Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Genetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animals
    NIH U01NS103522Aug 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Large-scale analysis of functional synapses during circuit plasticity with novel optogenetic sensors
    NIH U01NS103571Jun 1, 2017 - May 31, 2021
    Role: Co-Principal Investigator
    Microsystems for Modeling Neurodevelopmental Disorders
    NIH R21NS095325Apr 1, 2016 - Mar 31, 2019
    Role: Principal Investigator
    Genetically encoded sensors for the biogenic amines: watching neuromodulation in action
    NIH U01NS090604Sep 30, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Fluorescent biosensors for imaging neurotransmitters: observing synapses in actio
    NIH DP2MH107056Sep 19, 2014 - May 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus. Elife. 2024 Apr 09; 12. Wilmot JH, Diniz CRAF, Crestani AP, Puhger KR, Roshgadol J, Tian L, Wiltgen BJ. PMID: 38592773; PMCID: PMC11003744.
      View in: PubMed   Mentions:
    2. Sexual differentiation of neural mechanisms of stress sensitivity during puberty. Proc Natl Acad Sci U S A. 2023 10 24; 120(43):e2306475120. Wright EC, Luo PX, Zakharenkov HC, Serna Godoy A, Lake AA, Prince ZD, Sekar S, Culkin HI, Ramirez AV, Dwyer T, Kapoor A, Corbett C, Tian L, Fox AS, Trainor BC. PMID: 37847733; PMCID: PMC10614610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Temporal transcriptome and metabolite analyses provide insights into the biochemical and physiological processes underlying endodormancy release in pistachio (Pistacia vera L.) flower buds. Front Plant Sci. 2023; 14:1240442. Yu S, Amaral D, Brown PH, Ferguson L, Tian L. . PMID: 37810399; PMCID: PMC10556704.
      View in: PubMed   Mentions:
    4. From plastids to the cytosol: Redefining boundaries for provitamin A biofortification in plants. Mol Plant. 2023 07 03; 16(7):1109-1112. Yu S, Bekkering CS, Tian L. . PMID: 37403360.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Lighting up action potentials with fast and bright voltage sensors. Nat Methods. 2023 07; 20(7):990-992. Andreoni A, Tian L. PMID: 37429963.
      View in: PubMed   Mentions: 2     Fields:    
    6. Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023 02 17; 379(6633):700-706. Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE. PMID: 36795823; PMCID: PMC10108900.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    7. Genetic dissection of the roles of β-hydroxylases in carotenoid metabolism, photosynthesis, and plant growth in tetraploid wheat (Triticum turgidum L.). Theor Appl Genet. 2023 Jan; 136(1):8. Bekkering CS, Yu S, Isaka NN, Sproul BW, Dubcovsky J, Tian L. . PMID: 36656368; PMCID: PMC9852137.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors. Annu Rev Neurosci. 2022 07 08; 45:273-294. Dong C, Zheng Y, Long-Iyer K, Wright EC, Li Y, Tian L. PMID: 35316611; PMCID: PMC9940643.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    9. Mutational Analysis of a Wheat O-methyltransferase Involved in Flavonoid Metabolism. Plants (Basel). 2022 Jan 08; 11(2). Cain AB, Yu S, Tian L. . PMID: 35050052; PMCID: PMC8780298.
      View in: PubMed   Mentions: 2  
    10. Letting the little light of mind shine: Advances and future directions in neurochemical detection. Neurosci Res. 2022 Jun; 179:65-78. Tjahjono N, Jin Y, Hsu A, Roukes M, Tian L. PMID: 34861294; PMCID: PMC9508992.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Mutant combinations of lycopene ɛ-cyclase and β-carotene hydroxylase 2 homoeologs increased β-carotene accumulation in endosperm of tetraploid wheat (Triticum turgidum L.) grains. Plant Biotechnol J. 2022 03; 20(3):564-576. Yu S, Li M, Dubcovsky J, Tian L. . PMID: 34695292; PMCID: PMC8882798.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    12. Assessing the Role of Carotenoid Cleavage Dioxygenase 4 Homoeologs in Carotenoid Accumulation and Plant Growth in Tetraploid Wheat. Front Nutr. 2021; 8:740286. Yu S, Tian L. . PMID: 34568408; PMCID: PMC8455956.
      View in: PubMed   Mentions: 1  
    13. Metabolic engineering in woody plants: challenges, advances, and opportunities. aBIOTECH. 2021 Sep; 2(3):299-313. Yu S, Bekkering CS, Tian L. . PMID: 36303882; PMCID: PMC9590576.
      View in: PubMed   Mentions:
    14. Psychedelic-inspired drug discovery using an engineered biosensor. Cell. 2021 05 13; 184(10):2779-2792.e18. Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L. PMID: 33915107; PMCID: PMC8122087.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    15. Flavonoids in Cannabis sativa: Biosynthesis, Bioactivities, and Biotechnology. ACS Omega. 2021 Mar 02; 6(8):5119-5123. Bautista JL, Yu S, Tian L. . PMID: 33681553; PMCID: PMC7931196.
      View in: PubMed   Mentions: 30  
    16. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020 12 23; 183(7):1986-2002.e26. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. PMID: 33333022; PMCID: PMC8025677.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    17. An expanded palette of dopamine sensors for multiplex imaging in vivo. Nat Methods. 2020 11; 17(11):1147-1155. Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L. PMID: 32895537; PMCID: PMC8169200.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    18. Imaging voltage and brain chemistry with genetically encoded sensors and modulators. Curr Opin Chem Biol. 2020 08; 57:166-176. Pal A, Tian L. PMID: 32823064.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Marker-free carotenoid-enriched rice generated through targeted gene insertion using CRISPR-Cas9. Nat Commun. 2020 03 04; 11(1):1178. Dong OX, Yu S, Jain R, Zhang N, Duong PQ, Butler C, Li Y, Lipzen A, Martin JA, Barry KW, Schmutz J, Tian L, Ronald PC. PMID: 32132530; PMCID: PMC7055238.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    20. Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 Feb; 23(2):293. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31911656; PMCID: PMC7333455.
      View in: PubMed   Mentions: 2     Fields:    
    21. Thinking Outside of the Cereal Box: Breeding Underutilized (Pseudo)Cereals for Improved Human Nutrition. Front Genet. 2019; 10:1289. Bekkering CS, Tian L. . PMID: 31921317; PMCID: PMC6933008.
      View in: PubMed   Mentions: 7  
    22. Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 01; 23(1):15-20. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31844313; PMCID: PMC7257994.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    23. Measuring brain chemistry with genetically encoded fluorescent sensors. Current Opinion in Biomedical Engineering. 2019 Dec 1; 12:59-67. Andreoni AA, Davis DC, Tian TL. .
      View in: Publisher Site   Mentions:
    24. Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators. Nat Protoc. 2019 12; 14(12):3471-3505. Patriarchi T, Cho JR, Merten K, Marley A, Broussard GJ, Liang R, Williams J, Nimmerjahn A, von Zastrow M, Gradinaru V, Tian L. PMID: 31732722.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    25. Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Front Cell Neurosci. 2019; 13:499. Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA. PMID: 31798415; PMCID: PMC6874132.
      View in: PubMed   Mentions: 6  
    26. Phylogenomic analysis of UDP-dependent glycosyltransferases provides insights into the evolutionary landscape of glycosylation in plant metabolism. Plant J. 2019 12; 100(6):1273-1288. Wilson AE, Tian L. . PMID: 31446648.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    27. Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. Elife. 2019 09 23; 8. Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V. PMID: 31545171; PMCID: PMC6819083.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Publisher Correction: Dissociable dopamine dynamics for learning and motivation. Nature. 2019 Jul; 571(7763):E3. Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD. PMID: 31217588.
      View in: PubMed   Mentions: 3     Fields:    
    29. Temporally and Spatially Distinct Thirst Satiation Signals. Neuron. 2019 07 17; 103(2):242-249.e4. Augustine V, Ebisu H, Zhao Y, Lee S, Ho B, Mizuno GO, Tian L, Oka Y. PMID: 31153646; PMCID: PMC7335596.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    30. Dissociable dopamine dynamics for learning and motivation. Nature. 2019 06; 570(7759):65-70. Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD. PMID: 31118513; PMCID: PMC6555489.
      View in: PubMed   Mentions: 217     Fields:    Translation:AnimalsCells
    31. Maps of neuronal activity across the mouse brain. Nat Biomed Eng. 2019 05; 3(5):335-336. Andreoni A, Tian L. PMID: 31073176.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    32. A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. Neuron. 2019 01 02; 101(1):133-151.e7. de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S. PMID: 30503173; PMCID: PMC6317997.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    33. PgUGT95B2 preferentially metabolizes flavones/flavonols and has evolved independently from flavone/flavonol UGTs identified in Arabidopsis thaliana. Phytochemistry. 2019 Jan; 157:184-193. Wilson AE, Wu S, Tian L. . PMID: 30419412.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    34. Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. Elife. 2018 10 30; 7. Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C. PMID: 30373717; PMCID: PMC6207421.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    35. Distinctive Patterns of Flavonoid Biosynthesis in Roots and Nodules of Datisca glomerata and Medicago spp. Revealed by Metabolomic and Gene Expression Profiles. Front Plant Sci. 2018; 9:1463. Gifford I, Battenberg K, Vaniya A, Wilson A, Tian L, Fiehn O, Berry AM. PMID: 30364174; PMCID: PMC6192435.
      View in: PubMed   Mentions: 13  
    36. In vivo measurement of afferent activity with axon-specific calcium imaging. Nat Neurosci. 2018 09; 21(9):1272-1280. Broussard GJ, Liang Y, Fridman M, Unger EK, Meng G, Xiao X, Ji N, Petreanu L, Tian L. PMID: 30127424; PMCID: PMC6697169.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    37. Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Cell Rep. 2018 07 10; 24(2):355-365. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L. PMID: 29996097; PMCID: PMC6631348.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    38. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science. 2018 06 29; 360(6396). Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L. PMID: 29853555; PMCID: PMC6287765.
      View in: PubMed   Mentions: 367     Fields:    Translation:HumansAnimalsCells
    39. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L. PMID: 29476125; PMCID: PMC5824837.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. Cloning and functional characterization of a p-coumaroyl quinate/shikimate 3'-hydroxylase from potato (Solanum tuberosum). Biochem Biophys Res Commun. 2018 02 05; 496(2):462-467. Knollenberg BJ, Liu J, Yu S, Lin H, Tian L. . PMID: 29337064.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Imaging Glutamate with Genetically Encoded Fluorescent Sensors. . 2018 Jan 1; 130:117-153. Broussard BG, Unger UE, Liang LR, McGrew MB, Tian TL. .
      View in: Publisher Site   Mentions:
    42. Characterization of a UGT84 Family Glycosyltransferase Provides New Insights into Substrate Binding and Reactivity of Galloylglucose Ester-Forming UGTs. Biochemistry. 2017 Dec 05; 56(48):6389-6400. Wilson AE, Feng X, Ono NN, Holland D, Amir R, Tian L. . PMID: 29140084.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Breeding Major Cereal Grains through the Lens of Nutrition Sensitivity. Mol Plant. 2018 01 08; 11(1):23-30. Yu S, Tian L. . PMID: 28827167.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    44. Automated Functional Analysis of Astrocytes from Chronic Time-Lapse Calcium Imaging Data. Front Neuroinform. 2017; 11:48. Wang Y, Shi G, Miller DJ, Wang Y, Wang C, Broussard G, Wang Y, Tian L, Yu G. PMID: 28769780; PMCID: PMC5509822.
      View in: PubMed   Mentions: 4  
    45. Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides. ACS Comb Sci. 2017 05 08; 19(5):299-307. Carney RP, Thillier Y, Kiss Z, Sahabi A, Heleno Campos JC, Knudson A, Liu R, Olivos D, Saunders M, Tian L, Lam KS. PMID: 28378995; PMCID: PMC5901688.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. Advancing Human Health through Exploration of Plant Metabolism and Reaping the Benefits of Edible Medicinal Plants. Mol Plant. 2017 03 06; 10(3):533-536. Tian L, Hu Y, Chen XY. PMID: 28153709.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    47. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Rep. 2016 09 27; 17(1):165-178. Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. PMID: 27681429; PMCID: PMC5076887.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    48. Distinct expression and function of carotenoid metabolic genes and homoeologs in developing wheat grains. BMC Plant Biol. 2016 07 12; 16(1):155. Qin X, Fischer K, Yu S, Dubcovsky J, Tian L. . PMID: 27405473; PMCID: PMC4943016.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    49. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum). PLoS One. 2016; 11(5):e0156319. Ono NN, Qin X, Wilson AE, Li G, Tian L. . PMID: 27227328; PMCID: PMC4882073.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    50. FASP: A Machine Learning Approach to Functional Astrocyte Phenotyping from Time-Lapse Calcium Imaging Data. . 2016 Apr 1; 351-354. Wang WY, Shi SG, Miller MD, Wang WY, Broussard BG, Wang WY, Tian TL, Yu YG. .
      View in: Publisher Site   Mentions:
    51. Erratum: Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst Nanoeng. 2016; 2:16014. Gao Y, Broussard J, Haque A, Revzin A, Tian L. PMID: 31063160; PMCID: PMC6444724.
      View in: PubMed   Mentions: 1  
    52. Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device. Microsyst Nanoeng. 2016; 2:15045. Gao Y, Broussard J, Haque A, Revzin A, Lin T. PMID: 31057811; PMCID: PMC6444726.
      View in: PubMed   Mentions: 12  
    53. CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. Cell Rep. 2015 Dec 15; 13(10):2056-63. Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ. PMID: 26670043; PMCID: PMC4684969.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    54. Recent advances in understanding carotenoid-derived signaling molecules in regulating plant growth and development. Front Plant Sci. 2015; 6:790. Tian L. . PMID: 26442092; PMCID: PMC4585149.
      View in: PubMed   Mentions: 17  
    55. Imaging chemical neurotransmission with genetically encoded fluorescent sensors. ACS Chem Neurosci. 2015 Jan 21; 6(1):84-93. Liang R, Broussard GJ, Tian L. PMID: 25565280.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    56. Using Hairy Roots for Production of Valuable Plant Secondary Metabolites. Adv Biochem Eng Biotechnol. 2015; 149:275-324. Tian L. . PMID: 25583225.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    57. Monitoring activity in neural circuits with genetically encoded indicators. Front Mol Neurosci. 2014; 7:97. Broussard GJ, Liang R, Tian L. PMID: 25538558; PMCID: PMC4256991.
      View in: PubMed   Mentions: 64  
    58. Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Front Mol Neurosci. 2013; 6:2. Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL. PMID: 23459413; PMCID: PMC3586699.
      View in: PubMed   Mentions: 351  
    59. An optimized fluorescent probe for visualizing glutamate neurotransmission. Nat Methods. 2013 Feb; 10(2):162-70. Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL. PMID: 23314171; PMCID: PMC4469972.
      View in: PubMed   Mentions: 440     Fields:    Translation:AnimalsCells
    60. Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci. 2012 Oct 03; 32(40):13819-40. Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL. PMID: 23035093; PMCID: PMC3482105.
      View in: PubMed   Mentions: 646     Fields:    Translation:HumansAnimalsCells
    61. Cloning and comparative analysis of carotenoid β-hydroxylase genes provides new insights into carotenoid metabolism in tetraploid (Triticum turgidum ssp. durum) and hexaploid (Triticum aestivum) wheat grains. Plant Mol Biol. 2012 Dec; 80(6):631-46. Qin X, Zhang W, Dubcovsky J, Tian L. . PMID: 23015203; PMCID: PMC4783145.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsPHPublic Health
    62. Activity in motor-sensory projections reveals distributed coding in somatosensation. Nature. 2012 Sep 13; 489(7415):299-303. Petreanu L, Gutnisky DA, Huber D, Xu NL, O'Connor DH, Tian L, Looger L, Svoboda K. PMID: 22922646; PMCID: PMC3443316.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    63. Establishment of pomegranate (Punica granatum) hairy root cultures for genetic interrogation of the hydrolyzable tannin biosynthetic pathway. Planta. 2012 Sep; 236(3):931-41. Ono NN, Bandaranayake PC, Tian L. . PMID: 22810948.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    64. Imaging neuronal activity with genetically encoded calcium indicators. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):647-56. Tian L, Hires SA, Looger LL. PMID: 22661439.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    65. Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature. 2012 Apr 25; 484(7395):473-8. Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K. PMID: 22538608; PMCID: PMC4601999.
      View in: PubMed   Mentions: 265     Fields:    Translation:Animals
    66. Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4756-61. Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD. PMID: 22411832; PMCID: PMC3323987.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    67. A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo. J Neurosci. 2012 Feb 29; 32(9):3131-41. Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW. PMID: 22378886; PMCID: PMC3315707.
      View in: PubMed   Mentions: 231     Fields:    Translation:HumansAnimalsCells
    68. Neural activity imaging with genetically encoded calcium indicators. Prog Brain Res. 2012; 196:79-94. Tian L, Akerboom J, Schreiter ER, Looger LL. PMID: 22341322.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    69. Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery(F). J Integr Plant Biol. 2011 Oct; 53(10):800-13. Ono NN, Britton MT, Fass JN, Nicolet CM, Lin D, Tian L. . PMID: 21910825.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    70. Expression, subcellular localization, and cis-regulatory structure of duplicated phytoene synthase genes in melon (Cucumis melo L.). Planta. 2011 Oct; 234(4):737-48. Qin X, Coku A, Inoue K, Tian L. . PMID: 21626149.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    71. Copigmentation triggers the development of skin burning disorder on peach and nectarine fruit [Prunus persica (L.) Batsch]. J Agric Food Chem. 2011 Mar 23; 59(6):2393-402. Cantín CM, Tian L, Qin X, Crisosto CH. PMID: 21361290.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    72. Imaging light responses of targeted neuron populations in the rodent retina. J Neurosci. 2011 Feb 23; 31(8):2855-67. Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL. PMID: 21414907; PMCID: PMC3521507.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    73. The multiplicity of hairy root cultures: prolific possibilities. Plant Sci. 2011 Mar; 180(3):439-46. Ono NN, Tian L. . PMID: 21421390.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    74. Toward the second generation of optogenetic tools. J Neurosci. 2010 Nov 10; 30(45):14998-5004. Knöpfel T, Lin MZ, Levskaya A, Tian L, Lin JY, Boyden ES. PMID: 21068304; PMCID: PMC2997431.
      View in: PubMed   Mentions: 51     Fields:    
    75. Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nat Neurosci. 2010 Nov; 13(11):1433-40. Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW. PMID: 20890294; PMCID: PMC2967725.
      View in: PubMed   Mentions: 377     Fields:    Translation:AnimalsCells
    76. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods. 2009 Dec; 6(12):875-81. Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL. PMID: 19898485; PMCID: PMC2858873.
      View in: PubMed   Mentions: 1058     Fields:    Translation:HumansAnimalsCells
    77. Antibacterial activity of phenolic compounds against the phytopathogen Xylella fastidiosa. Curr Microbiol. 2010 Jan; 60(1):53-8. Maddox CE, Laur LM, Tian L. . PMID: 19813054; PMCID: PMC2796966.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    78. Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. BMC Plant Biol. 2009 Jan 05; 9:1. Tian L, Peel GJ, Lei Z, Aziz N, Dai X, He J, Watson B, Zhao PX, Sumner LW, Dixon RA. PMID: 19123941; PMCID: PMC2630931.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    79. Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design. J Biol Chem. 2009 Mar 06; 284(10):6455-64. Akerboom J, Rivera JD, Guilbe MM, Malavé EC, Hernandez HH, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER. PMID: 19098007; PMCID: PMC2649101.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    80. Reporting neural activity with genetically encoded calcium indicators. Brain Cell Biol. 2008 Aug; 36(1-4):69-86. Hires SA, Tian L, Looger LL. PMID: 18941901; PMCID: PMC2755531.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    81. Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems. Drug Discov Today Dis Models. 2008; 5(1):27-35. Tian L, Looger LL. PMID: 19461949; PMCID: PMC2651031.
      View in: PubMed   Mentions: 7  
    82. Erratum: Where to start and when to stop. Nature Structural & Molecular Biology. 2006 Sep 1; 13(9):855-855. Tian TL, Matouschek MA. .
      View in: Publisher Site   Mentions:
    83. Where to start and when to stop. Nat Struct Mol Biol. 2006 Aug; 13(8):668-70. Tian L, Matouschek A. PMID: 16886005.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    84. A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB. Nat Struct Mol Biol. 2005 Dec; 12(12):1045-53. Tian L, Holmgren RA, Matouschek A. PMID: 16299518.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    85. An unstructured initiation site is required for efficient proteasome-mediated degradation. Nat Struct Mol Biol. 2004 Sep; 11(9):830-7. Prakash S, Tian L, Ratliff KS, Lehotzky RE, Matouschek A. PMID: 15311270.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
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