Yang Kevin Xiang

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-6895
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovasc Res. 2021 Aug 29; 117(10):2237-2251. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. PMID: 32956449.
      View in: PubMed   Mentions: 3     Fields:    
    2. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 01 22; 128(2):246-261. Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. PMID: 33183171.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 10 20; 11(1):5303. Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. PMID: 33082339.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. PMID: 32507058.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice. Diabetes. 2020 06; 69(6):1292-1305. Sun X, Han F, Lu Q, Li X, Ren D, Zhang J, Han Y, Xiang YK, Li J. PMID: 32234722.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. PMID: 32213702.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. PMID: 31960515.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 10 14; 8. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. PMID: 31609201.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife. 2019 08 06; 8. Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. PMID: 31386623.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Correction to: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 Jul 26; 12(1):83. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31349855.
      View in: PubMed   Mentions:    Fields:    
    11. Phosphodiesterase 5 Associates With β2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts. J Am Heart Assoc. 2019 08 06; 8(15):e012273. West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK. PMID: 31311394.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    12. Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda). 2019 07 01; 34(4):240-249. Bers DM, Xiang YK, Zaccolo M. PMID: 31165682.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 06 10; 12(1):56. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31182116.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    14. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. β-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 04; 597(8):2139-2162. Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. PMID: 30714156.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 30821687.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. PMID: 30242036.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene. J Appl Bioinforma Comput Biol. 2018; 7(3). Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D. PMID: 31058201.
      View in: PubMed   Mentions: 1  
    19. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. PMID: 30146163.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Dev Cell. 2018 05 07; 45(3):362-375.e3. Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM, Xiang YK, Yasuda R, Chen B, Shen K. PMID: 29738713.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    21. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 04 26; 61(8):3541-3550. Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. PMID: 29614224.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. PMID: 29535304.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    23. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L. PMID: 29476125.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. PMID: 28860381.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    25. β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes. Sci Rep. 2017 08 11; 7(1):7890. Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF. PMID: 28801655.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors. J Cardiovasc Pharmacol. 2017 Aug; 70(2):74-86. Fu Q, Shi Q, West TM, Xiang YK. PMID: 28328746.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes. Cardiovasc Res. 2017 May 01; 113(6):656-670. Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. PMID: 28339772.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7. Sci Rep. 2017 03 15; 7:44584. Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA. PMID: 28294194.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    29. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. Fu Q, Wang Q, Xiang YK. PMID: 28256297.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 03 15; 595(6):1973-1986. Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK. PMID: 27983752.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. PMID: 27815373.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    32. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Elife. 2016 10 05; 5. Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K. PMID: 27705746.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    33. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circ Res. 2016 09 30; 119(8):888-90. Chen X, O'Connell TD, Xiang YK. PMID: 27688302.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    34. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK, Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. PMID: 27576469; PMCID: PMC5307331.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    35. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins. Cell Signal. 2016 08; 28(8):1001-14. Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K, Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K. PMID: 27155323.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW, Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. PMID: 27103070; PMCID: PMC4910527.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity. PLoS One. 2016; 11(3):e0150125. Zhao H, Shen A, Xiang YK, Corey DP, Zhao H, Shen A, Xiang YK, Corey DP. PMID: 26943906; PMCID: PMC4778845.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC, Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. PMID: 26095046; PMCID: PMC4546705.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    39. Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88. Fu Q, Xiang YK, Fu Q, Xiang YK. PMID: 26055058; PMCID: PMC7328190.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes. Cardiovasc Res. 2015 Jun 01; 106(3):408-20. Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F, Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F. PMID: 25852085.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    41. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes. Cell Signal. 2015 Mar; 27(3):707-15. Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK, Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK. PMID: 25460042; PMCID: PMC4333100.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem. 2014 May 23; 289(21):14771-81. Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK, Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. PMID: 24713698; PMCID: PMC4031532.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    43. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK, Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. PMID: 24677713; PMCID: PMC4113065.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    44. Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet. 2014 Aug 01; 23(15):4024-34. Wisely EV, Xiang YK, Oddo S, Wisely EV, Xiang YK, Oddo S. PMID: 24626633; PMCID: PMC4082366.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. Clancy CE, Xiang YK, Clancy CE, Xiang YK. PMID: 24598634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Gadd45β is transcriptionally activated by p53 via p38α-mediated phosphorylation during myocardial ischemic injury. J Mol Med (Berl). 2013 Nov; 91(11):1303-13. Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS, Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS. PMID: 23948959.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. PLoS One. 2013; 8(5):e63379. Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW, Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW. PMID: 23696820; PMCID: PMC3656048.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    48. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW, Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. PMID: 23649627; PMCID: PMC3682589.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    49. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct; 23(7):250-6. Fu Q, Chen X, Xiang YK, Fu Q, Chen X, Xiang YK. PMID: 23528751; PMCID: PMC4264830.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK, Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. PMID: 23430246; PMCID: PMC3624413.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    51. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P, Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. PMID: 23329830; PMCID: PMC3591621.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    52. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circ Res. 2013 Feb 01; 112(3):498-509. Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X, Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. PMID: 23104882; PMCID: PMC3562387.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    53. Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. PLoS One. 2012; 7(8):e42658. Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK, Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. PMID: 22912718; PMCID: PMC3415400.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    54. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6578-83. Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK, Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. PMID: 22493261; PMCID: PMC3340097.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    55. MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes. Eur J Pharmacol. 2012 Apr 15; 681(1-3):80-7. Sellers ZM, Naren AP, Xiang Y, Best PM, Sellers ZM, Naren AP, Xiang Y, Best PM. PMID: 22381067; PMCID: PMC3307910.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    56. Single-molecule pull-down for studying protein interactions. Nat Protoc. 2012 Feb 09; 7(3):445-52. Jain A, Liu R, Xiang YK, Ha T, Jain A, Liu R, Xiang YK, Ha T. PMID: 22322217; PMCID: PMC3654178.
      View in: PubMed   Mentions: 68     Fields:    
    57. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia. Adv Exp Med Biol. 2012; 758:287-94. Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J, Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. PMID: 23080174; PMCID: PMC3715042.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    58. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA, Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. PMID: 21918105; PMCID: PMC3329869.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    59. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem. 2011 Sep 09; 286(36):31852-63. Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK, Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. PMID: 21757762; PMCID: PMC3173113.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    60. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011 Jul 08; 109(2):231-44. Xiang YK, Xiang YK. PMID: 21737818; PMCID: PMC3493619.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    61. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci. 2011 Jul 01; 124(Pt 13):2153-64. He Y, Kapoor A, Cook S, Liu S, Xiang Y, Rao CV, Kenis PJ, Wang F, He Y, Kapoor A, Cook S, Liu S, Xiang Y, Rao CV, Kenis PJ, Wang F. PMID: 21628423; PMCID: PMC3113669.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    62. Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26; 473(7348):484-8. Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T, Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T. PMID: 21614075; PMCID: PMC3103084.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansCells
    63. β-adrenergic receptor, amyloid β-peptide, and Alzheimer's disease. Curr Top Membr. 2011; 67:205-28. Wang D, Xiang YK, Wang D, Xiang YK. PMID: 21771492.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    64. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. Biochem Biophys Res Commun. 2011 Jan 14; 404(2):581-6. Liu S, Zhang J, Xiang YK, Liu S, Zhang J, Xiang YK. PMID: 21130738; PMCID: PMC3025313.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    65. Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol. 2010 Sep; 78(3):340-9. De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK, De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK. PMID: 20530128; PMCID: PMC2939479.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    66. Biofunctionalized nanoneedles for the direct and site-selective delivery of probes into living cells. Biochim Biophys Acta. 2011 Mar; 1810(3):330-8. Yum K, Yu MF, Wang N, Xiang YK, Yum K, Yu MF, Wang N, Xiang YK. PMID: 20580773; PMCID: PMC2948073.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    67. Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate. J Physiol. 2010 Jul 01; 588(Pt 13):2417-29. Sellers ZM, De Arcangelis V, Xiang Y, Best PM, Sellers ZM, De Arcangelis V, Xiang Y, Best PM. PMID: 20442264; PMCID: PMC2915517.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    68. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 2010 Sep; 24(9):3511-21. Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK, Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK. PMID: 20395454; PMCID: PMC2923357.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    69. Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK. Circ Res. 2010 Jan 08; 106(1):79-88. Cervantes D, Crosby C, Xiang Y, Cervantes D, Crosby C, Xiang Y. PMID: 19926878; PMCID: PMC2818802.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    70. Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem. 2009 Dec 04; 284(49):33824-32. De Arcangelis V, Liu R, Soto D, Xiang Y, De Arcangelis V, Liu R, Soto D, Xiang Y. PMID: 19801680; PMCID: PMC2797152.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    71. Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes. J Biol Chem. 2009 Nov 20; 284(47):32279-87. Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y, Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. PMID: 19706594; PMCID: PMC2781641.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    72. Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living cells. Nano Lett. 2009 May; 9(5):2193-8. Yum K, Na S, Xiang Y, Wang N, Yu MF, Yum K, Na S, Xiang Y, Wang N, Yu MF. PMID: 19366190; PMCID: PMC2710808.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    73. Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res. 2009 Mar 27; 104(6):770-9. Soto D, De Arcangelis V, Zhang J, Xiang Y, Soto D, De Arcangelis V, Zhang J, Xiang Y. PMID: 19213958; PMCID: PMC3075876.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    74. Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology. 2009 Mar; 34(4):1067-77. Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM, Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. PMID: 18923403; PMCID: PMC2727683.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    75. Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. Mol Pharmacol. 2008 Nov; 74(5):1453-62. De Arcangelis V, Soto D, Xiang Y, De Arcangelis V, Soto D, Xiang Y. PMID: 18703669; PMCID: PMC2654611.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    76. Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. J Biol Chem. 2008 Jan 25; 283(4):1799-807. Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y, Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y. PMID: 18056263.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    77. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol. 2007 Aug; 72(2):429-39. Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y, Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. PMID: 17510209.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    78. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol. 2007 Feb 12; 176(4):521-33. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK, Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. PMID: 17296797; PMCID: PMC2063986.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    79. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 2007 Jan 10; 26(1):53-64. Sun Y, Huang J, Xiang Y, Bastepe M, Jüppner H, Kobilka BK, Zhang JJ, Huang XY, Sun Y, Huang J, Xiang Y, Bastepe M, Jüppner H, Kobilka BK, Zhang JJ, Huang XY. PMID: 17170700; PMCID: PMC1782364.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    80. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J. 2005 Feb 23; 24(4):717-29. Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G, Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G. PMID: 15692567; PMCID: PMC549619.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCells
    81. Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):909-14. Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B, Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. PMID: 15644445; PMCID: PMC544184.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    82. The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J. 2003 Dec 01; 22(23):6234-44. Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G, Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G. PMID: 14633983; PMCID: PMC291837.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    83. The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. Mol Pharmacol. 2003 Nov; 64(5):1048-58. Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP, Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP. PMID: 14573753.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    84. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem. 2004 Jan 02; 279(1):686-91. Swaminath G, Xiang Y, Lee TW, Steenhuis J, Parnot C, Kobilka BK, Swaminath G, Xiang Y, Lee TW, Steenhuis J, Parnot C, Kobilka BK. PMID: 14559905.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    85. The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10776-81. Xiang Y, Kobilka B, Xiang Y, Kobilka B. PMID: 12954981; PMCID: PMC196879.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    86. Myocyte adrenoceptor signaling pathways. Science. 2003 Jun 06; 300(5625):1530-2. Xiang Y, Kobilka BK, Xiang Y, Kobilka BK. PMID: 12791980.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    87. The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem. 2002 Sep 13; 277(37):33783-90. Xiang Y, Devic E, Kobilka B, Xiang Y, Devic E, Kobilka B. PMID: 12097326.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    88. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 2002 Sep 13; 277(37):34280-6. Xiang Y, Rybin VO, Steinberg SF, Kobilka B, Xiang Y, Rybin VO, Steinberg SF, Kobilka B. PMID: 12097322.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    89. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol. 2001 Sep; 60(3):577-83. Devic E, Xiang Y, Gould D, Kobilka B, Devic E, Xiang Y, Gould D, Kobilka B. PMID: 11502890.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    90. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem. 2001 Nov 09; 276(45):42063-9. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA, Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. PMID: 11533056.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    91. PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO J. 2001 May 01; 20(9):2191-201. Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G, Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G. PMID: 11331585; PMCID: PMC125242.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    92. The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell. 2000 Apr; 11(4):1257-73. Xiang Y, Molloy SS, Thomas L, Thomas G, Xiang Y, Molloy SS, Thomas L, Thomas G. PMID: 10749928; PMCID: PMC14845.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    93. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24; 94(2):205-16. Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G, Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G. PMID: 9695949.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    94. alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7293-8. Jean F, Stella K, Thomas L, Liu G, Xiang Y, Reason AJ, Thomas G, Jean F, Stella K, Thomas L, Liu G, Xiang Y, Reason AJ, Thomas G. PMID: 9636142; PMCID: PMC22594.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells