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Yang Kevin Xiang

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-6895
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. Hyperinsulinemia promotes heterologous desensitization of ß2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 Jan 21. PMID: 31960515.
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    2. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. ß-blockers augment L-type Ca2+ channel activity by targeting spatially restricted ß2AR signaling in neurons. Elife. 2019 10 14; 8. PMID: 31609201.
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    3. Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife. 2019 08 06; 8. PMID: 31386623.
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    4. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. Correction to: High-affinity peptide ligand LXY30 for targeting a3ß1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 Jul 26; 12(1):83. PMID: 31349855.
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    5. West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK. Phosphodiesterase 5 Associates With ß2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts. J Am Heart Assoc. 2019 Aug 06; 8(15):e012273. PMID: 31311394.
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    6. Bers DM, Xiang YK, Zaccolo M. Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda). 2019 07 01; 34(4):240-249. PMID: 31165682.
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    7. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. High-affinity peptide ligand LXY30 for targeting a3ß1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 Jun 10; 12(1):56. PMID: 31182116.
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    8. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. PMID: 31162142.
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    9. Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. ß-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 Apr; 597(8):2139-2162. PMID: 30714156.
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    10. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. PMID: 30821687.
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    11. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. PMID: 30242036.
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    12. Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene. J Appl Bioinforma Comput Biol. 2018; 7(3). PMID: 31058201.
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    13. Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. PMID: 30146163.
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    14. Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM, Xiang YK, Yasuda R, Chen B, Shen K. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Dev Cell. 2018 05 07; 45(3):362-375.e3. PMID: 29738713.
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    15. Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 04 26; 61(8):3541-3550. PMID: 29614224.
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    16. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. PMID: 29535304.
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    17. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. PMID: 29476125.
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    18. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. ß2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. PMID: 28860381.
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    19. Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF. ß1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes. Sci Rep. 2017 08 11; 7(1):7890. PMID: 28801655.
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    20. Fu Q, Shi Q, West TM, Xiang YK. Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors. J Cardiovasc Pharmacol. 2017 Aug; 70(2):74-86. PMID: 28328746.
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    21. Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. Heterologous desensitization of cardiac ß-adrenergic signal via hormone-induced ßAR/arrestin/PDE4 complexes. Cardiovasc Res. 2017 May 01; 113(6):656-670. PMID: 28339772.
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    22. Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7. Sci Rep. 2017 03 15; 7:44584. PMID: 28294194.
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    23. Fu Q, Wang Q, Xiang YK. Insulin and ß Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. PMID: 28256297.
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    24. Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of ß2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 03 15; 595(6):1973-1986. PMID: 27983752.
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    25. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated ß2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. PMID: 27815373.
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    26. Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Elife. 2016 10 05; 5. PMID: 27705746.
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    27. Chen X, O'Connell TD, Xiang YK. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circ Res. 2016 09 30; 119(8):888-90. PMID: 27688302.
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    28. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. PMID: 27576469.
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    29. Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and ß-arrestins. Cell Signal. 2016 08; 28(8):1001-14. PMID: 27155323.
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    30. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ß2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. PMID: 27103070.
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    31. Zhao H, Shen A, Xiang YK, Corey DP. Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity. PLoS One. 2016; 11(3):e0150125. PMID: 26943906.
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    32. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. PMID: 26095046.
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    33. Fu Q, Xiang YK. Trafficking of ß-Adrenergic Receptors: Implications in Intracellular Receptor Signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88. PMID: 26055058.
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    34. Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F. Inhibition of type 5 phosphodiesterase counteracts ß2-adrenergic signalling in beating cardiomyocytes. Cardiovasc Res. 2015 Jun 01; 106(3):408-20. PMID: 25852085.
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    35. Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated ß2AR internalization to attenuate ßAR signaling in cardiomyocytes. Cell Signal. 2015 Mar; 27(3):707-15. PMID: 25460042.
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    36. Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. A long lasting ß1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem. 2014 May 23; 289(21):14771-81. PMID: 24713698.
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    37. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased ß2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. PMID: 24677713.
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    38. Wisely EV, Xiang YK, Oddo S. Genetic suppression of ß2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet. 2014 Aug 01; 23(15):4024-34. PMID: 24626633.
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    39. Clancy CE, Xiang YK. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. PMID: 24598634.
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    40. Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS. Gadd45ß is transcriptionally activated by p53 via p38a-mediated phosphorylation during myocardial ischemic injury. J Mol Med (Berl). 2013 Nov; 91(11):1303-13. PMID: 23948959.
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    41. Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW. SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. PLoS One. 2013; 8(5):e63379. PMID: 23696820.
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    42. Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic ß-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. PMID: 23649627.
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    43. Fu Q, Chen X, Xiang YK. Compartmentalization of ß-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct; 23(7):250-6. PMID: 23528751.
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    44. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. ß2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. PMID: 23430246.
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    45. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1a complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. PMID: 23329830.
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    46. Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. Cardiotoxic and cardioprotective features of chronic ß-adrenergic signaling. Circ Res. 2013 Feb 01; 112(3):498-509. PMID: 23104882.
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    47. Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. Palmitoylation regulates intracellular trafficking of ß2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. PLoS One. 2012; 7(8):e42658. PMID: 22912718.
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    48. Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6578-83. PMID: 22493261.
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    49. Sellers ZM, Naren AP, Xiang Y, Best PM. MRP4 and CFTR in the regulation of cAMP and ß-adrenergic contraction in cardiac myocytes. Eur J Pharmacol. 2012 Apr 15; 681(1-3):80-7. PMID: 22381067.
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    50. Jain A, Liu R, Xiang YK, Ha T. Single-molecule pull-down for studying protein interactions. Nat Protoc. 2012 Feb 09; 7(3):445-52. PMID: 22322217.
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    51. Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia. Adv Exp Med Biol. 2012; 758:287-94. PMID: 23080174.
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    52. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. PMID: 21918105.
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    53. Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem. 2011 Sep 09; 286(36):31852-63. PMID: 21757762.
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    54. Xiang YK. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011 Jul 08; 109(2):231-44. PMID: 21737818.
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    55. He Y, Kapoor A, Cook S, Liu S, Xiang Y, Rao CV, Kenis PJ, Wang F. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci. 2011 Jul 01; 124(Pt 13):2153-64. PMID: 21628423.
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    56. Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T. Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26; 473(7348):484-8. PMID: 21614075.
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    57. Wang D, Xiang YK. ß-adrenergic receptor, amyloid ß-peptide, and Alzheimer's disease. Curr Top Membr. 2011; 67:205-28. PMID: 21771492.
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    58. Liu S, Zhang J, Xiang YK. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes. Biochem Biophys Res Commun. 2011 Jan 14; 404(2):581-6. PMID: 21130738.
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    59. De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK. Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol. 2010 Sep; 78(3):340-9. PMID: 20530128.
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    60. Yum K, Yu MF, Wang N, Xiang YK. Biofunctionalized nanoneedles for the direct and site-selective delivery of probes into living cells. Biochim Biophys Acta. 2011 Mar; 1810(3):330-8. PMID: 20580773.
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    61. Sellers ZM, De Arcangelis V, Xiang Y, Best PM. Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate. J Physiol. 2010 Jul 01; 588(Pt 13):2417-29. PMID: 20442264.
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    62. Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 2010 Sep; 24(9):3511-21. PMID: 20395454.
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    63. Cervantes D, Crosby C, Xiang Y. Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK. Circ Res. 2010 Jan 08; 106(1):79-88. PMID: 19926878.
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    64. De Arcangelis V, Liu R, Soto D, Xiang Y. Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem. 2009 Dec 04; 284(49):33824-32. PMID: 19801680.
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    65. Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes. J Biol Chem. 2009 Nov 20; 284(47):32279-87. PMID: 19706594.
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    66. Yum K, Na S, Xiang Y, Wang N, Yu MF. Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living cells. Nano Lett. 2009 May; 9(5):2193-8. PMID: 19366190.
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    67. Soto D, De Arcangelis V, Zhang J, Xiang Y. Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res. 2009 Mar 27; 104(6):770-9. PMID: 19213958.
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    68. Zhang HT, Whisler LR, Huang Y, Xiang Y, O'Donnell JM. Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology. 2009 Mar; 34(4):1067-77. PMID: 18923403.
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    69. De Arcangelis V, Soto D, Xiang Y. Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. Mol Pharmacol. 2008 Nov; 74(5):1453-62. PMID: 18703669.
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    70. Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y. Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. J Biol Chem. 2008 Jan 25; 283(4):1799-807. PMID: 18056263.
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    71. Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol. 2007 Aug; 72(2):429-39. PMID: 17510209.
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    72. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol. 2007 Feb 12; 176(4):521-33. PMID: 17296797.
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    73. Sun Y, Huang J, Xiang Y, Bastepe M, Jüppner H, Kobilka BK, Zhang JJ, Huang XY. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 2007 Jan 10; 26(1):53-64. PMID: 17170700.
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    74. Simmen T, Aslan JE, Blagoveshchenskaya AD, Thomas L, Wan L, Xiang Y, Feliciangeli SF, Hung CH, Crump CM, Thomas G. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J. 2005 Feb 23; 24(4):717-29. PMID: 15692567.
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    75. Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):909-14. PMID: 15644445.
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    76. Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G. The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J. 2003 Dec 01; 22(23):6234-44. PMID: 14633983.
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    77. Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP. The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. Mol Pharmacol. 2003 Nov; 64(5):1048-58. PMID: 14573753.
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    78. Swaminath G, Xiang Y, Lee TW, Steenhuis J, Parnot C, Kobilka BK. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J Biol Chem. 2004 Jan 02; 279(1):686-91. PMID: 14559905.
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    79. Xiang Y, Kobilka B. The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10776-81. PMID: 12954981.
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    80. Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science. 2003 Jun 06; 300(5625):1530-2. PMID: 12791980.
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    81. Xiang Y, Devic E, Kobilka B. The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem. 2002 Sep 13; 277(37):33783-90. PMID: 12097326.
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    82. Xiang Y, Rybin VO, Steinberg SF, Kobilka B. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 2002 Sep 13; 277(37):34280-6. PMID: 12097322.
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    83. Devic E, Xiang Y, Gould D, Kobilka B. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol. 2001 Sep; 60(3):577-83. PMID: 11502890.
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    84. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem. 2001 Nov 09; 276(45):42063-9. PMID: 11533056.
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    85. Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G. PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO J. 2001 May 01; 20(9):2191-201. PMID: 11331585.
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    86. Xiang Y, Molloy SS, Thomas L, Thomas G. The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell. 2000 Apr; 11(4):1257-73. PMID: 10749928.
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    87. Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24; 94(2):205-16. PMID: 9695949.
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    88. Jean F, Stella K, Thomas L, Liu G, Xiang Y, Reason AJ, Thomas G. alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7293-8. PMID: 9636142.
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