Yang Kevin Xiang

Title(s)Professor, Pharmacology
SchoolSchool of Medicine
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    1. Monoamine Oxidases Desensitize Intracellular �1AR Signaling in Heart Failure. Circ Res. 2021 10 29; 129(10):965-967. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. PMID: 34530626; PMCID: PMC8556367.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Carvedilol induces biased �1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility. Cardiovasc Res. 2021 08 29; 117(10):2237-2251. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. PMID: 32956449; PMCID: PMC8502477.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Intracellular �1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 01 22; 128(2):246-261. Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. PMID: 33183171; PMCID: PMC7856104.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    4. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 10 20; 11(1):5303. Prada MP, Syed AU, Reddy GR, Mart?n-Arag?n Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintr?n M. PMID: 33082339; PMCID: PMC7575592.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    5. GRK5 Controls SAP97-Dependent Cardiotoxic �1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 08 28; 127(6):796-810. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. PMID: 32507058; PMCID: PMC7484403.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Empagliflozin Ameliorates Obesity-Related Cardiac Dysfunction by Regulating Sestrin2-Mediated AMPK-mTOR Signaling and Redox Homeostasis in High-Fat Diet-Induced Obese Mice. Diabetes. 2020 06; 69(6):1292-1305. Sun X, Han F, Lu Q, Li X, Ren D, Zhang J, Han Y, Xiang YK, Li J. PMID: 32234722.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    7. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 03 26; 5(6). Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. PMID: 32213702; PMCID: PMC7213803.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. Hyperinsulinemia promotes heterologous desensitization of �2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. PMID: 31960515.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. �-blockers augment L-type Ca2+ channel activity by targeting spatially restricted �2AR signaling in neurons. Elife. 2019 10 14; 8. Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. PMID: 31609201; PMCID: PMC6813027.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife. 2019 08 06; 8. Lee J, Taylor CA, Barnes KM, Shen A, Stewart EV, Chen A, Xiang YK, Bao Z, Shen K. PMID: 31386623; PMCID: PMC6684318.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Correction to: High-affinity peptide ligand LXY30 for targeting a3�1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 Jul 26; 12(1):83. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31349855; PMCID: PMC6660960.
      View in: PubMed   Mentions: 1     Fields:    
    12. Phosphodiesterase 5 Associates With �2 Adrenergic Receptor to Modulate Cardiac Function in Type 2 Diabetic Hearts. J Am Heart Assoc. 2019 08 06; 8(15):e012273. West TM, Wang Q, Deng B, Zhang Y, Barbagallo F, Reddy GR, Chen D, Phan KS, Xu B, Isidori A, Xiang YK. PMID: 31311394; PMCID: PMC6761630.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    13. Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters. Physiology (Bethesda). 2019 07 01; 34(4):240-249. Bers DM, Xiang YK, Zaccolo M. PMID: 31165682; PMCID: PMC6863374.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    14. High-affinity peptide ligand LXY30 for targeting a3�1 integrin in non-small cell lung cancer. J Hematol Oncol. 2019 06 10; 12(1):56. Xiao W, Ma W, Wei S, Li Q, Liu R, Carney RP, Yang K, Lee J, Nyugen A, Yoneda KY, Lam KS, Li T. PMID: 31182116; PMCID: PMC6558829.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    15. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 06 04; 129(8):3140-3152. Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. PMID: 31162142; PMCID: PMC6668679.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    16. �-adrenergic-mediated dynamic augmentation of sarcolemmal CaV 1.2 clustering and co-operativity in ventricular myocytes. J Physiol. 2019 04; 597(8):2139-2162. Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. PMID: 30714156; PMCID: PMC6462464.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Sim? S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintr?n M, Navedo MF. PMID: 30821687; PMCID: PMC6397001.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. PMID: 30242036; PMCID: PMC6219686.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B2 Adrenergic Receptor Gene. J Appl Bioinforma Comput Biol. 2018; 7(3). Zhou Y, Chen L, Zhou X, Pei Y, Wei S, Mehmood A, Xiang YK, Wang D. PMID: 31058201; PMCID: PMC6497178.
      View in: PubMed   Mentions: 1  
    20. The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell. 2018 09 06; 174(6):1436-1449.e20. Maeder CI, Kim JI, Liang X, Kaganovsky K, Shen A, Li Q, Li Z, Wang S, Xu XZS, Li JB, Xiang YK, Ding JB, Shen K. PMID: 30146163; PMCID: PMC6542560.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators to Drive Efficient F-Actin Assembly and Branching. Dev Cell. 2018 05 07; 45(3):362-375.e3. Zou W, Dong X, Broederdorf TR, Shen A, Kramer DA, Shi R, Liang X, Miller DM, Xiang YK, Yasuda R, Chen B, Shen K. PMID: 29738713; PMCID: PMC6292511.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain. J Med Chem. 2018 04 26; 61(8):3541-3550. Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. PMID: 29614224; PMCID: PMC5933862.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 03 13; 9(1):1050. Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. PMID: 29535304; PMCID: PMC5849717.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Sci Rep. 2018 02 23; 8(1):3556. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L. PMID: 29476125; PMCID: PMC5824837.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. �2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. Mittal S, Bj?rnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Sch?le B, Park DS, Riise T, Scherzer CR. PMID: 28860381; PMCID: PMC5761666.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    26. �1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes. Sci Rep. 2017 08 11; 7(1):7890. Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF. PMID: 28801655; PMCID: PMC5554155.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    27. Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors. J Cardiovasc Pharmacol. 2017 Aug; 70(2):74-86. Fu Q, Shi Q, West TM, Xiang YK. PMID: 28328746; PMCID: PMC5734060.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes. Cardiovasc Res. 2017 May 01; 113(6):656-670. Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. PMID: 28339772; PMCID: PMC5852637.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    29. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7. Sci Rep. 2017 03 15; 7:44584. Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA. PMID: 28294194; PMCID: PMC5353686.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    30. Insulin and � Adrenergic Receptor Signaling: Crosstalk in Heart. Trends Endocrinol Metab. 2017 06; 28(6):416-427. Fu Q, Wang Q, Xiang YK. PMID: 28256297; PMCID: PMC5535765.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    31. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of �2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017 03 15; 595(6):1973-1986. Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK. PMID: 27983752; PMCID: PMC5350441.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Inhibiting Insulin-Mediated �2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 03; 135(1):73-88. Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. PMID: 27815373; PMCID: PMC5302024.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    33. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Elife. 2016 10 05; 5. Zou W, Shen A, Dong X, Tugizova M, Xiang YK, Shen K. PMID: 27705746; PMCID: PMC5079751.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    34. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circ Res. 2016 09 30; 119(8):888-90. Chen X, O'Connell TD, Xiang YK. PMID: 27688302; PMCID: PMC5361738.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    35. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30; 119(8):931-43. Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. PMID: 27576469; PMCID: PMC5307331.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    36. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and �-arrestins. Cell Signal. 2016 08; 28(8):1001-14. Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K. PMID: 27155323.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    37. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the �2 adrenergic receptor. EMBO J. 2016 06 15; 35(12):1330-45. Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. PMID: 27103070; PMCID: PMC4910527.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    38. Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity. PLoS One. 2016; 11(3):e0150125. Zhao H, Shen A, Xiang YK, Corey DP. PMID: 26943906; PMCID: PMC4778845.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    39. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised �-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 02; 17(1):89-100. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. PMID: 26095046; PMCID: PMC4546705.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    40. Trafficking of �-Adrenergic Receptors: Implications in Intracellular Receptor Signaling. Prog Mol Biol Transl Sci. 2015; 132:151-88. Fu Q, Xiang YK. PMID: 26055058; PMCID: PMC7328190.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. Inhibition of type 5 phosphodiesterase counteracts �2-adrenergic signalling in beating cardiomyocytes. Cardiovasc Res. 2015 Jun 01; 106(3):408-20. Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, Naro F. PMID: 25852085.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    42. Insulin induces IRS2-dependent and GRK2-mediated �2AR internalization to attenuate �AR signaling in cardiomyocytes. Cell Signal. 2015 Mar; 27(3):707-15. Fu Q, Xu B, Parikh D, Cervantes D, Xiang YK. PMID: 25460042; PMCID: PMC4333100.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    43. A module of human peripheral blood mononuclear cell transcriptional network containing primitive and differentiation markers is related to specific cardiovascular health variables. PLoS One. 2014; 9(4):e95124. Moldovan L, Anghelina M, Kantor T, Jones D, Ramadan E, Xiang Y, Huang K, Kolipaka A, Malarkey W, Ghasemzadeh N, Mohler PJ, Quyyumi A, Moldovan NI. PMID: 24759906; PMCID: PMC3997360.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    44. A long lasting �1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem. 2014 May 23; 289(21):14771-81. Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. PMID: 24713698; PMCID: PMC4031532.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. Insulin inhibits cardiac contractility by inducing a Gi-biased �2-adrenergic signaling in hearts. Diabetes. 2014 Aug; 63(8):2676-89. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. PMID: 24677713; PMCID: PMC4113065.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    46. Genetic suppression of �2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies. Hum Mol Genet. 2014 Aug 01; 23(15):4024-34. Wisely EV, Xiang YK, Oddo S. PMID: 24626633; PMCID: PMC4082366.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. Clancy CE, Xiang YK. PMID: 24598634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Gadd45� is transcriptionally activated by p53 via p38a-mediated phosphorylation during myocardial ischemic injury. J Mol Med (Berl). 2013 Nov; 91(11):1303-13. Kim YA, Kim MY, Yu HY, Mishra SK, Lee JH, Choi KS, Kim JH, Xiang YK, Jung YS. PMID: 23948959.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    49. SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains. PLoS One. 2013; 8(5):e63379. Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW. PMID: 23696820; PMCID: PMC3656048.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic �-adrenergic signaling. J Biol Chem. 2013 Jun 14; 288(24):17918-31. Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW. PMID: 23649627; PMCID: PMC3682589.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    51. Compartmentalization of �-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med. 2013 Oct; 23(7):250-6. Fu Q, Chen X, Xiang YK. PMID: 23528751; PMCID: PMC4264830.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    52. �2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem. 2013 Apr 12; 288(15):10298-307. Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK. PMID: 23430246; PMCID: PMC3624413.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    53. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1a complex. J Biol Chem. 2013 Mar 08; 288(10):7117-26. Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P. PMID: 23329830; PMCID: PMC3591621.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    54. Cardiotoxic and cardioprotective features of chronic �-adrenergic signaling. Circ Res. 2013 Feb 01; 112(3):498-509. Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. PMID: 23104882; PMCID: PMC3562387.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    55. Palmitoylation regulates intracellular trafficking of �2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. PLoS One. 2012; 7(8):e42658. Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK. PMID: 22912718; PMCID: PMC3415400.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    56. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6578-83. Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. PMID: 22493261; PMCID: PMC3340097.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    57. MRP4 and CFTR in the regulation of cAMP and �-adrenergic contraction in cardiac myocytes. Eur J Pharmacol. 2012 Apr 15; 681(1-3):80-7. Sellers ZM, Naren AP, Xiang Y, Best PM. PMID: 22381067; PMCID: PMC3307910.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    58. Single-molecule pull-down for studying protein interactions. Nat Protoc. 2012 Feb 09; 7(3):445-52. Jain A, Liu R, Xiang YK, Ha T. PMID: 22322217; PMCID: PMC3654178.
      View in: PubMed   Mentions: 82     Fields:    
    59. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia. Adv Exp Med Biol. 2012; 758:287-94. Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. PMID: 23080174; PMCID: PMC3715042.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    60. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci Transl Med. 2011 Sep 14; 3(100):100ra88. Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, Kass DA. PMID: 21918105; PMCID: PMC3329869.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    61. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem. 2011 Sep 09; 286(36):31852-63. Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. PMID: 21757762; PMCID: PMC3173113.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    62. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res. 2011 Jul 08; 109(2):231-44. Xiang YK. PMID: 21737818; PMCID: PMC3493619.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
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