Loading...

Ye Chen-Izu

Title(s)Professor, Pharmacology
SchoolUniversity of California, Davis
Phone530-752-3232
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. J Physiol. 2019 Dec 02. PMID: 31789427.
      View in: PubMed
    2. Hegyi B, Chen-Izu Y, Izu LT, Bányász T. Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and ß-adrenergic stimulation. Can J Physiol Pharmacol. 2019 Aug; 97(8):773-780. PMID: 31091413.
      View in: PubMed
    3. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and ß-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. PMID: 30879336.
      View in: PubMed
    4. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. PMID: 30242036.
      View in: PubMed
    5. Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y. ß-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018 10; 123:168-179. PMID: 30240676.
      View in: PubMed
    6. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 03 16; 8(1):4670. PMID: 29549309.
      View in: PubMed
    7. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. PMID: 29531045.
      View in: PubMed
    8. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and ß-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005852. PMID: 29437761.
      View in: PubMed
    9. Coulibaly Z, Chen-Izu Y, Izu LT. Avoiding phantasms. Cardiovasc Res. 2017 12 01; 113(14):1703-1704. PMID: 29036639.
      View in: PubMed
    10. Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). PMID: 29025768.
      View in: PubMed
    11. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu LT, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 08; 109:27-37. PMID: 28668303.
      View in: PubMed
    12. Bers DM, Chen-Izu Y. K+ channels and cardiac electrophysiology. J Physiol. 2017 04 01; 595(7):2205-2207. PMID: 28370016.
      View in: PubMed
    13. Chen-Izu Y, Izu LT. Mechano-chemo-transduction in cardiac myocytes. J Physiol. 2017 06 15; 595(12):3949-3958. PMID: 28098356.
      View in: PubMed
    14. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. PMID: 27808412.
      View in: PubMed
    15. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. PMID: 27861921.
      View in: PubMed
    16. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu LT. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. PMID: 27653489.
      View in: PubMed
    17. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. PMID: 27500929.
      View in: PubMed
    18. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036.
      View in: PubMed
    19. Izu LT, Bányász T, Chen-Izu Y. Optimizing Population Variability to Maximize Benefit. PLoS One. 2015; 10(12):e0143475. PMID: 26650247.
      View in: PubMed
    20. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. PMID: 26643875.
      View in: PubMed
    21. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu LT, Banyasz T. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):173-6. PMID: 26463508.
      View in: PubMed
    22. Nakajima KI, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 2015 Oct 09; 6:8532. PMID: 26449415.
      View in: PubMed
    23. Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. J Mol Cell Cardiol. 2015 Aug; 85:240-8. PMID: 26092277.
      View in: PubMed
    24. Chen-Izu Y, Izu LT. Measuring the metrics: Correlating t-tubule structure and muscle contraction in the intact heart. J Mol Cell Cardiol. 2015 Aug; 85:153-4. PMID: 26031703.
      View in: PubMed
    25. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. J Physiol. 2015 Mar 15; 593(6):1429-42. PMID: 25545172.
      View in: PubMed
    26. Bers DM, Chen-Izu Y. Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia. J Physiol. 2015 Mar 15; 593(6):1327-9. PMID: 25772288.
      View in: PubMed
    27. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289.
      View in: PubMed
    28. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
      View in: PubMed
    29. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291.
      View in: PubMed
    30. Banyasz T, Szentandrássy N, Magyar J, Szabo Z, Nánási PP, Chen-Izu Y, Izu LT. An emerging antiarrhythmic target: late sodium current. Curr Pharm Des. 2015; 21(8):1073-90. PMID: 25354179.
      View in: PubMed
    31. Makris EA, Huang BJ, Hu JC, Chen-Izu Y, Athanasiou KA. Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Eng Part A. 2015 Mar; 21(5-6):884-94. PMID: 25473799.
      View in: PubMed
    32. Svensson B, Oda T, Nitu FR, Yang Y, Cornea I, Chen-Izu Y, Fessenden JD, Bers DM, Thomas DD, Cornea RL. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophys J. 2014 Nov 04; 107(9):2037-48. PMID: 25418089.
      View in: PubMed
    33. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. PMID: 24643800.
      View in: PubMed
    34. Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu LT, Chen-Izu Y. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov; 466(11):2067-76. PMID: 24535581.
      View in: PubMed
    35. Shaw J, Izu L, Chen-Izu Y. Mechanical analysis of single myocyte contraction in a 3-D elastic matrix. PLoS One. 2013; 8(10):e75492. PMID: 24098388.
      View in: PubMed
    36. Horvath B, Banyasz T, Jian Z, Hegyi B, Kistamas K, Nanasi PP, Izu LT, Chen-Izu Y. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol. 2013 Nov; 64:59-68. PMID: 24012538.
      View in: PubMed
    37. Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. The force-frequency relationship: insights from mathematical modeling. Adv Physiol Educ. 2013 Mar; 37(1):28-34. PMID: 23471245.
      View in: PubMed
    38. Izu LT, Xie Y, Sato D, Bányász T, Chen-Izu Y. Ca²? waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. PMID: 23220129.
      View in: PubMed
    39. Izu LT, Chen-Izu Y. Une cellule type? J Mol Cell Cardiol. 2012 May; 52(5):921-2. PMID: 22326436.
      View in: PubMed
    40. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes. Heart Rhythm. 2012 Jan; 9(1):134-42. PMID: 21884673.
      View in: PubMed
    41. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol. 2011 Mar; 50(3):578-81. PMID: 21215755.
      View in: PubMed
    42. Bányász T, Szentandrássy N, Tóth A, Nánási PP, Magyar J, Chen-Izu Y. Cardiac calmodulin kinase: a potential target for drug design. Curr Med Chem. 2011; 18(24):3707-13. PMID: 21774758.
      View in: PubMed
    43. Chen-Izu Y, Izu LT. Cellular cartography. Biophys J. 2010 Dec 15; 99(12):3861-2. PMID: 21156126.
      View in: PubMed
    44. Chen-Izu Y. Multiple levels of the single L-type Ca2+ channel conductance in adult mammalian ventricular myocytes. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):604-8. PMID: 19932083.
      View in: PubMed
    45. Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu LT, Balke CW. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol. 2008 Mar; 93(3):370-82. PMID: 18156167.
      View in: PubMed
    46. Chen L, Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 Jan; 104(1):218-23. PMID: 18006871.
      View in: PubMed
    47. Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, Izu LT, Balke CW. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3301-10. PMID: 17873027.
      View in: PubMed
    48. Izu LT, Bányász T, Balke CW, Chen-Izu Y. Eavesdropping on the social lives of Ca(2+) sparks. Biophys J. 2007 Nov 15; 93(10):3408-20. PMID: 17675349.
      View in: PubMed
    49. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. PMID: 17630346.
      View in: PubMed
    50. Bányász T, Chen-Izu Y, Balke CW, Izu LT. A new approach to the detection and statistical classification of Ca2+ sparks. Biophys J. 2007 Jun 15; 92(12):4458-65. PMID: 17400702.
      View in: PubMed
    51. Chen-Izu Y, William Balke C. Progress in the development of a unifying hypothesis on the mechanisms underlying the electrical and mechanical abnormalities of the failing heart: one step backward but two steps forward. J Mol Cell Cardiol. 2006 Sep; 41(3):424-5. PMID: 16884736.
      View in: PubMed
    52. Izu LT, Means SA, Shadid JN, Chen-Izu Y, Balke CW. Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J. 2006 Jul 01; 91(1):95-112. PMID: 16603499.
      View in: PubMed
    53. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu LT. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006 Jul 01; 91(1):1-13. PMID: 16603500.
      View in: PubMed
    54. Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003 Mar 01; 547(Pt 2):441-51. PMID: 12562899.
      View in: PubMed
    55. Chen-Izu Y, Moreno AP, Spangler RA. Opposing gates model for voltage gating of gap junction channels. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1604-13. PMID: 11600424.
      View in: PubMed
    56. Chen-Izu Y, Sha Q, Shorofsky SR, Robinson SW, Wier WG, Goldman L, Balke CW. I(Ca(TTX)) channels are distinct from those generating the classical cardiac Na(+) current. Biophys J. 2001 Nov; 81(5):2647-59. PMID: 11606278.
      View in: PubMed
    57. Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J. 2000 Nov; 79(5):2547-56. PMID: 11053129.
      View in: PubMed
    58. Kuschel M, Zhou YY, Cheng H, Zhang SJ, Chen Y, Lakatta EG, Xiao RP. G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. J Biol Chem. 1999 Jul 30; 274(31):22048-52. PMID: 10419531.
      View in: PubMed
    59. Sham JS, Song LS, Chen Y, Deng LH, Stern MD, Lakatta EG, Cheng H. Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15096-101. PMID: 9844021.
      View in: PubMed
    60. Dahl E, Manthey D, Chen Y, Schwarz HJ, Chang YS, Lalley PA, Nicholson BJ, Willecke K. Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin. J Biol Chem. 1996 Jul 26; 271(30):17903-10. PMID: 8663509.
      View in: PubMed
    61. Chen Y, Simasko SM, Niggel J, Sigurdson WJ, Sachs F. Ca2+ uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels. Am J Physiol. 1996 Jun; 270(6 Pt 1):C1790-8. PMID: 8764163.
      View in: PubMed
    62. Izu YC, Sachs F. Inhibiting synthesis of extracellular matrix improves patch clamp seal formation. Pflugers Arch. 1991 Sep; 419(2):218-20. PMID: 1720520.
      View in: PubMed