Ye Chen-Izu

Title(s)Professor, Med: Pharmacology
SchoolSchool of Medicine
AddressDavis Campsu
CA 95616
Phone530-752-3232
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    Other Positions
    Title(s)Professor, Biomedical Engineering

    Title(s)Professor in Residence, MED: Int Med Cardiology (Sac)


    Collapse Research 
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    Decipher Mechano-Chemo-Transduction Pathway and Function in Cardiomyocytes
    NIH R01HL159993Sep 1, 2021 - Jul 31, 2025
    Role: Principal Investigator
    The Functional Connectome of the Mechanically Loaded Cardiomyocyte
    NIH R01HL149431Dec 10, 2019 - Nov 30, 2023
    Role: Co-Principal Investigator
    Systems Approach to Understanding Cardiac Arrhythmias Mechanisms
    NIH R13HL147532May 1, 2019 - Apr 30, 2020
    Role: Principal Investigator
    MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLING
    NIH R01HL141460Jan 1, 2019 - Nov 30, 2022
    Role: Principal Investigator
    Mechanics and Energetics in Cardiac Arrhythmias and Heart Failure
    NIH R13HL139086Feb 15, 2018 - Jan 31, 2019
    Role: Principal Investigator
    Systems Approach to understanding Excitation-Coupling and Cardiac Arrhythmias
    NIH R13HL132515Mar 2, 2016 - Feb 28, 2017
    Role: Principal Investigator
    Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell Level
    NIH R01HL123526Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias
    NIH R13HL110618Apr 1, 2012 - Mar 31, 2013
    Role: Principal Investigator
    CaMKII Inhibition as a New Therapeutic Strategy for Treating Hypertension-induced
    NIH R03AG031944Jan 15, 2009 - Dec 31, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Heart is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect. Annu Rev Physiol. 2024 Dec 03. Chen-Izu Y, Banyasz T, Shaw JA, Izu LT. PMID: 39626239.
      View in: PubMed   Mentions:    Fields:    
    2. α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure. J Am Heart Assoc. 2024 Oct 15; 13(20):e035375. Flores-Tamez VA, Martín-Aragón Baudel M, Hong J, Taylor JL, Ren L, Le T, Syed AU, Moustafa Y, Singhrao N, Lemus-Martinez WR, Reddy GR, Ramer V, Man KNM, Bartels P, Chen-Izu Y, Chen CY, Simo S, Dickson EJ, Morotti S, Grandi E, Santana LF, Hell JW, Horne MC, Nieves-Cintrón M, Navedo MF. PMID: 39377203.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2. Proc Natl Acad Sci U S A. 2024 Sep 24; 121(39):e2318900121. Woltz RL, Zheng Y, Choi W, Ngo K, Trinh P, Ren L, Thai PN, Harris BJ, Han Y, Rouen KC, Mateos DL, Jian Z, Chen-Izu Y, Dickson EJ, Yamoah EN, Yarov-Yarovoy V, Vorobyov I, Zhang XD, Chiamvimonvat N. PMID: 39288178; PMCID: PMC11441529.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. On QSAR-based cardiotoxicity modeling with the expressiveness-enhanced graph learning model and dual-threshold scheme. Front Physiol. 2023; 14:1156286. Wang H, Zhu G, Izu LT, Chen-Izu Y, Ono N, Altaf-Ul-Amin MD, Kanaya S, Huang M. PMID: 37228825; PMCID: PMC10203956.
      View in: PubMed   Mentions: 1  
    5. INNOVATIVE TECHNIQUES AND NEW INSIGHTS: Studying cardiac ionic currents and action potentials in physiologically relevant conditions. Physiol Mini Rev. 2023 May-Jun; 16(3):22-34. Chen-Izu Y, Hegyi B, Jian Z, Horvath B, Shaw JA, Banyasz T, Izu LT. PMID: 38107545; PMCID: PMC10722976.
      View in: PubMed   Mentions:
    6. A training pipeline of an arrhythmia classifier for atrial fibrillation detection using Photoplethysmography signal. Front Physiol. 2023; 14:1084837. Kudo S, Chen Z, Zhou X, Izu LT, Chen-Izu Y, Zhu X, Tamura T, Kanaya S, Huang M. PMID: 36744032; PMCID: PMC9892629.
      View in: PubMed   Mentions: 2  
    7. Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload-induced increases in Ca2+ transient and Ca2+ sparks. J Physiol. 2022 11; 600(22):4865-4879. Alim CC, Ko CY, Mira Hernandez J, Shen EY, Baidar S, Chen-Izu Y, Bers DM, Bossuyt J. PMID: 36227145; PMCID: PMC9827875.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Erratum: Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback. iScience. 2022 Sep 16; 25(9):104810. Kazemi-Lari MA, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw JA, Wineman AS, Chen-Izu Y. PMID: 36034223; PMCID: PMC9399277.
      View in: PubMed   Mentions:
    9. Modeling cardiomyocyte mechanics and autoregulation of contractility by mechano-chemo-transduction feedback. iScience. 2022 Jul 15; 25(7):104667. Kazemi-Lari MA, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw JA, Wineman AS, Chen-Izu Y. PMID: 35860762; PMCID: PMC9289640.
      View in: PubMed   Mentions: 1  
    10. Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique. Front Physiol. 2022; 13:864002. Horváth B, Szentandrássy N, Dienes C, Kovács ZM, Nánási PP, Chen-Izu Y, Izu LT, Banyasz T. PMID: 35370800; PMCID: PMC8966222.
      View in: PubMed   Mentions: 1  
    11. Beat-to-beat dynamic regulation of intracellular pH in cardiomyocytes. iScience. 2022 Jan 21; 25(1):103624. Lyu Y, Thai PN, Ren L, Timofeyev V, Jian Z, Park S, Ginsburg KS, Overton J, Bossuyt J, Bers DM, Yamoah EN, Chen-Izu Y, Chiamvimonvat N, Zhang XD. PMID: 35005560; PMCID: PMC8718820.
      View in: PubMed   Mentions: 5  
    12. Mechanoelectric coupling and arrhythmogenesis in cardiomyocytes contracting under mechanical afterload in a 3D viscoelastic hydrogel. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Hegyi B, Shimkunas R, Jian Z, Izu LT, Bers DM, Chen-Izu Y. PMID: 34326268; PMCID: PMC8346795.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. A viscoelastic Eshelby inclusion model and analysis of the Cell-in-Gel system. Int J Eng Sci. 2021 Aug 01; 165. Kazemi-Lari MA, Shaw JA, Wineman AS, Shimkunas R, Jian Z, Hegyi B, Izu L, Chen-Izu Y. PMID: 34629507; PMCID: PMC8500226.
      View in: PubMed   Mentions: 4  
    14. Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes. Life (Basel). 2021 May 29; 11(6). Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, Shaw J, Banyasz T, Chen-Izu Y. PMID: 34072584; PMCID: PMC8227646.
      View in: PubMed   Mentions: 3  
    15. Mechanical Load Regulates Excitation-Ca2+ Signaling-Contraction in Cardiomyocyte. Circ Res. 2021 03 19; 128(6):772-774. Shimkunas R, Hegyi B, Jian Z, Shaw JA, Kazemi-Lari MA, Mitra D, Leach JK, Li X, Jaradeh M, Balardi N, Chen YJ, Escobar AL, Baker AJ, Bossuyt J, Banyasz T, Chiamvimonvat N, Lam KS, Bers DM, Izu LT, Chen-Izu Y. PMID: 33601939; PMCID: PMC7979518.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Mechanics and energetics in cardiac arrhythmias and heart failure. J Physiol. 2020 04; 598(7):1275-1277. Bers DM, Kohl P, Chen-Izu Y. PMID: 31998965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Balance Between Rapid Delayed Rectifier K+ Current and Late Na+ Current on Ventricular Repolarization: An Effective Antiarrhythmic Target? Circ Arrhythm Electrophysiol. 2020 04; 13(4):e008130. Hegyi B, Chen-Izu Y, Izu LT, Rajamani S, Belardinelli L, Bers DM, Bányász T. PMID: 32202931; PMCID: PMC7331791.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    18. Mechano-electric and mechano-chemo-transduction in cardiomyocytes. J Physiol. 2020 04; 598(7):1285-1305. Izu LT, Kohl P, Boyden PA, Miura M, Banyasz T, Chiamvimonvat N, Trayanova N, Bers DM, Chen-Izu Y. PMID: 31789427; PMCID: PMC7127983.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. Altered K+ current profiles underlie cardiac action potential shortening in hyperkalemia and β-adrenergic stimulation. Can J Physiol Pharmacol. 2019 Aug; 97(8):773-780. Hegyi B, Chen-Izu Y, Izu LT, Bányász T. PMID: 31091413; PMCID: PMC10286692.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and β-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 03; 12(3):e007061. Hegyi B, Morotti S, Liu C, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Bányász T, Grandi E, Bers DM. PMID: 30879336; PMCID: PMC6720130.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    21. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 11 05; 150(11):1567-1582. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. PMID: 30242036; PMCID: PMC6219686.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018 10; 123:168-179. Hegyi B, Bányász T, Izu LT, Belardinelli L, Bers DM, Chen-Izu Y. PMID: 30240676; PMCID: PMC6201263.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    23. Viscoelastic Eshelby Analysis of Cardiomyocyte Contraction in the Cell-in-Gel System. . 2018 Sep 10; v002t02a016-v002t02a016. Kazemi-Lari KM, Shaw SJ, Wineman WA, Shimkunas SR, Izu IL, Chen-Izu CY. .
      View in: Publisher Site   Mentions:
    24. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 03 16; 8(1):4670. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. PMID: 29549309; PMCID: PMC5856806.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    25. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E3036-E3044. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varró A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Bányász T, Bers DM, Chen-Izu Y. PMID: 29531045; PMCID: PMC5879679.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    26. Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005852. Hegyi B, Bossuyt J, Ginsburg KS, Mendoza LM, Talken L, Ferrier WT, Pogwizd SM, Izu LT, Chen-Izu Y, Bers DM. PMID: 29437761; PMCID: PMC5813707.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    27. Avoiding phantasms. Cardiovasc Res. 2017 12 01; 113(14):1703-1704. Coulibaly Z, Chen-Izu Y, Izu LT. PMID: 29036639; PMCID: PMC5852615.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    28. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. PMID: 29025768; PMCID: PMC5662469.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Ca2+-activated Cl- current is antiarrhythmic by reducing both spatial and temporal heterogeneity of cardiac repolarization. J Mol Cell Cardiol. 2017 08; 109:27-37. Hegyi B, Horváth B, Váczi K, Gönczi M, Kistamás K, Ruzsnavszky F, Veress R, Izu LT, Chen-Izu Y, Bányász T, Magyar J, Csernoch L, Nánási PP, Szentandrássy N. PMID: 28668303; PMCID: PMC5995131.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. K+ channels and cardiac electrophysiology. J Physiol. 2017 04 01; 595(7):2205-2207. Bers DM, Chen-Izu Y. PMID: 28370016; PMCID: PMC5374116.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Mechano-chemo-transduction in cardiac myocytes. J Physiol. 2017 06 15; 595(12):3949-3958. Chen-Izu Y, Izu LT. PMID: 28098356; PMCID: PMC5471413.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. PMID: 27808412; PMCID: PMC5374105.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    33. Multimodal second harmonic generation and two photon fluorescence imaging of microdomain calcium contraction coupling in single cardiomyocytes. Proceedings of SPIE. 2016 Nov 24; 10013:1001304-1001304-7. Chan CJ, Awasthi AS, Izu IL, Mao MZ, Jian JZ, Landas LT, Lerner LA, Shimkunas SR, Woldeyesus WR, Bossuyt BJ, Wood WB, Chen CY, Matthews MD, Lieu LD, Chiamvimonvat CN, Lam LK, Chen-Izu CY. .
      View in: Publisher Site   Mentions:
    34. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 04 01; 595(7):2209-2228. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. PMID: 27861921; PMCID: PMC5374109.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    35. Electrophysiological Determination of Submembrane Na(+) Concentration in Cardiac Myocytes. Biophys J. 2016 Sep 20; 111(6):1304-1315. Hegyi B, Bányász T, Shannon TR, Chen-Izu Y, Izu LT. PMID: 27653489; PMCID: PMC5034366.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    36. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. PLoS One. 2016; 11(8):e0160605. Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. PMID: 27500929; PMCID: PMC4976940.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. PMID: 27318036; PMCID: PMC5026590.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    38. Optimizing Population Variability to Maximize Benefit. PLoS One. 2015; 10(12):e0143475. Izu LT, Bányász T, Chen-Izu Y. PMID: 26650247; PMCID: PMC4674128.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Multimodal SHG-2PF Imaging of Microdomain Ca2+-Contraction Coupling in Live Cardiac Myocytes. Circ Res. 2016 01 22; 118(2):e19-28. Awasthi S, Izu LT, Mao Z, Jian Z, Landas T, Lerner A, Shimkunas R, Woldeyesus R, Bossuyt J, Wood BM, Chen YJ, Matthews DL, Lieu DK, Chiamvimonvat N, Lam KS, Chen-Izu Y, Chan JW. PMID: 26643875; PMCID: PMC4740258.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. KN-93 inhibits IKr in mammalian cardiomyocytes. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):173-6. Hegyi B, Chen-Izu Y, Jian Z, Shimkunas R, Izu LT, Banyasz T. PMID: 26463508; PMCID: PMC4689637.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    41. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 2015 Oct 09; 6:8532. Nakajima KI, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. PMID: 26449415; PMCID: PMC4603535.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    42. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. J Mol Cell Cardiol. 2015 Aug; 85:240-8. Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. PMID: 26092277; PMCID: PMC4530019.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    43. Measuring the metrics: Correlating t-tubule structure and muscle contraction in the intact heart. J Mol Cell Cardiol. 2015 Aug; 85:153-4. Chen-Izu Y, Izu LT. PMID: 26031703.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. J Physiol. 2015 Mar 15; 593(6):1429-42. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. PMID: 25545172; PMCID: PMC4376422.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia. J Physiol. 2015 Mar 15; 593(6):1327-9. Bers DM, Chen-Izu Y. PMID: 25772288; PMCID: PMC4376413.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    46. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. PMID: 25772289; PMCID: PMC4376414.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    47. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    48. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291; PMCID: PMC4376416.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    49. An emerging antiarrhythmic target: late sodium current. Curr Pharm Des. 2015; 21(8):1073-90. Banyasz T, Szentandrássy N, Magyar J, Szabo Z, Nánási PP, Chen-Izu Y, Izu LT. PMID: 25354179.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    50. Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Eng Part A. 2015 Mar; 21(5-6):884-94. Makris EA, Huang BJ, Hu JC, Chen-Izu Y, Athanasiou KA. PMID: 25473799; PMCID: PMC4356188.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophys J. 2014 Nov 04; 107(9):2037-48. Svensson B, Oda T, Nitu FR, Yang Y, Cornea I, Chen-Izu Y, Fessenden JD, Bers DM, Thomas DD, Cornea RL. PMID: 25418089; PMCID: PMC4223179.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    52. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Sci Signal. 2014 Mar 18; 7(317):ra27. Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, Banyasz T, Tardiff JC, Chiamvimonvat N, Bers DM, Lam KS, Chen-Izu Y. PMID: 24643800; PMCID: PMC4103414.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    53. Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential. Pflugers Arch. 2014 Nov; 466(11):2067-76. Banyasz T, Jian Z, Horvath B, Khabbaz S, Izu LT, Chen-Izu Y. PMID: 24535581; PMCID: PMC4138296.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    54. Mechanical analysis of single myocyte contraction in a 3-D elastic matrix. PLoS One. 2013; 8(10):e75492. Shaw J, Izu L, Chen-Izu Y. PMID: 24098388; PMCID: PMC3789722.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    55. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations. J Mol Cell Cardiol. 2013 Nov; 64:59-68. Horvath B, Banyasz T, Jian Z, Hegyi B, Kistamas K, Nanasi PP, Izu LT, Chen-Izu Y. PMID: 24012538; PMCID: PMC3856763.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    56. The force-frequency relationship: insights from mathematical modeling. Adv Physiol Educ. 2013 Mar; 37(1):28-34. Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. PMID: 23471245; PMCID: PMC3776472.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    57. Ca²⁺ waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. Izu LT, Xie Y, Sato D, Bányász T, Chen-Izu Y. PMID: 23220129; PMCID: PMC3660086.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    58. Une cellule type? J Mol Cell Cardiol. 2012 May; 52(5):921-2. Izu LT, Chen-Izu Y. PMID: 22326436; PMCID: PMC3727390.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    59. Profile of L-type Ca(2+) current and Na(+)/Ca(2+) exchange current during cardiac action potential in ventricular myocytes. Heart Rhythm. 2012 Jan; 9(1):134-42. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. PMID: 21884673; PMCID: PMC3252888.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    60. Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp. J Mol Cell Cardiol. 2011 Mar; 50(3):578-81. Banyasz T, Horvath B, Jian Z, Izu LT, Chen-Izu Y. PMID: 21215755; PMCID: PMC3047417.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    61. Cardiac calmodulin kinase: a potential target for drug design. Curr Med Chem. 2011; 18(24):3707-13. Bányász T, Szentandrássy N, Tóth A, Nánási PP, Magyar J, Chen-Izu Y. PMID: 21774758; PMCID: PMC3940595.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    62. Cellular cartography. Biophys J. 2010 Dec 15; 99(12):3861-2. Chen-Izu Y, Izu LT. PMID: 21156126; PMCID: PMC3000499.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    63. Multiple levels of the single L-type Ca2+ channel conductance in adult mammalian ventricular myocytes. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):604-8. Chen-Izu Y. PMID: 19932083; PMCID: PMC2818605.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    64. Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol. 2008 Mar; 93(3):370-82. Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu LT, Balke CW. PMID: 18156167.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    65. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 Jan; 104(1):218-23. Chen L, Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM. PMID: 18006871.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    66. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3301-10. Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, Izu LT, Balke CW. PMID: 17873027.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    67. Eavesdropping on the social lives of Ca(2+) sparks. Biophys J. 2007 Nov 15; 93(10):3408-20. Izu LT, Bányász T, Balke CW, Chen-Izu Y. PMID: 17675349; PMCID: PMC2072070.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    68. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. PMID: 17630346.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    69. A new approach to the detection and statistical classification of Ca2+ sparks. Biophys J. 2007 Jun 15; 92(12):4458-65. Bányász T, Chen-Izu Y, Balke CW, Izu LT. PMID: 17400702; PMCID: PMC1877760.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    70. Progress in the development of a unifying hypothesis on the mechanisms underlying the electrical and mechanical abnormalities of the failing heart: one step backward but two steps forward. J Mol Cell Cardiol. 2006 Sep; 41(3):424-5. Chen-Izu Y, William Balke C. PMID: 16884736.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    71. Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J. 2006 Jul 01; 91(1):95-112. Izu LT, Means SA, Shadid JN, Chen-Izu Y, Balke CW. PMID: 16603499; PMCID: PMC1479049.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    72. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J. 2006 Jul 01; 91(1):1-13. Chen-Izu Y, McCulle SL, Ward CW, Soeller C, Allen BM, Rabang C, Cannell MB, Balke CW, Izu LT. PMID: 16603500; PMCID: PMC1479079.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    73. Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003 Mar 01; 547(Pt 2):441-51. Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. PMID: 12562899; PMCID: PMC2342655.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    74. I(Ca(TTX)) channels are distinct from those generating the classical cardiac Na(+) current. Biophys J. 2001 Nov; 81(5):2647-59. Chen-Izu Y, Sha Q, Shorofsky SR, Robinson SW, Wier WG, Goldman L, Balke CW. PMID: 11606278; PMCID: PMC1301732.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    75. Opposing gates model for voltage gating of gap junction channels. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1604-13. Chen-Izu Y, Moreno AP, Spangler RA. PMID: 11600424.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    76. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels. Biophys J. 2000 Nov; 79(5):2547-56. Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. PMID: 11053129; PMCID: PMC1301137.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    77. G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. J Biol Chem. 1999 Jul 30; 274(31):22048-52. Kuschel M, Zhou YY, Cheng H, Zhang SJ, Chen Y, Lakatta EG, Xiao RP. PMID: 10419531.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    78. Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15096-101. Sham JS, Song LS, Chen Y, Deng LH, Stern MD, Lakatta EG, Cheng H. PMID: 9844021; PMCID: PMC24581.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    79. Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin. J Biol Chem. 1996 Jul 26; 271(30):17903-10. Dahl E, Manthey D, Chen Y, Schwarz HJ, Chang YS, Lalley PA, Nicholson BJ, Willecke K. PMID: 8663509.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    80. Ca2+ uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels. Am J Physiol. 1996 Jun; 270(6 Pt 1):C1790-8. Chen Y, Simasko SM, Niggel J, Sigurdson WJ, Sachs F. PMID: 8764163.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    81. Inhibiting synthesis of extracellular matrix improves patch clamp seal formation. Pflugers Arch. 1991 Sep; 419(2):218-20. Izu YC, Sachs F. PMID: 1720520.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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