Xiaodong Zhang

Title(s)Associate Adjunct Professor, Cardiovascular Medicine
SchoolSchool of Medicine
Phone530-754-7158
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat Commun. 2024 Jan 16; 15(1):526. Lee JH, Perez-Flores MC, Park S, Kim HJ, Chen Y, Kang M, Kersigo J, Choi J, Thai PN, Woltz RL, Perez-Flores DC, Perkins G, Sihn CR, Trinh P, Zhang XD, Sirish P, Dong Y, Feng WW, Pessah IN, Dixon RE, Sokolowski B, Fritzsch B, Chiamvimonvat N, Yamoah EN. PMID: 38228630; PMCID: PMC10791687.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Targeting Small-Conductance Calcium-Activated Potassium Channels in Atrial Fibrillation: Therapeutic Opportunities. Circ Res. 2023 04 28; 132(9):1104-1106. Zhang XD, Chiamvimonvat N. PMID: 37104564; PMCID: PMC10155264.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2206708119. Ren L, Gopireddy RR, Perkins G, Zhang H, Timofeyev V, Lyu Y, Diloretto DA, Trinh P, Sirish P, Overton JL, Xu W, Grainger N, Xiang YK, Dedkova EN, Zhang XD, Yamoah EN, Navedo MF, Thai PN, Chiamvimonvat N. PMID: 36044551; PMCID: PMC9456763.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. Protocol to record and quantify the intracellular pH in contracting cardiomyocytes. STAR Protoc. 2022 06 17; 3(2):101301. Lyu Y, Timofeyev V, Overton J, Thai PN, Yamoah EN, Chiamvimonvat N, Zhang XD. PMID: 35463464; PMCID: PMC9026584.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Beat-to-beat dynamic regulation of intracellular pH in cardiomyocytes. iScience. 2022 Jan 21; 25(1):103624. Lyu Y, Thai PN, Ren L, Timofeyev V, Jian Z, Park S, Ginsburg KS, Overton J, Bossuyt J, Bers DM, Yamoah EN, Chen-Izu Y, Chiamvimonvat N, Zhang XD. PMID: 35005560; PMCID: PMC8718820.
      View in: PubMed   Mentions: 5  
    6. Protocol to assess two distinct components of the nonlinear capacitance in mouse cardiomyocytes. STAR Protoc. 2021 12 17; 2(4):100891. Zhang XD, Flores MCP, Timofeyev V, Yamoah EN, Chiamvimonvat N. PMID: 34704077; PMCID: PMC8521203.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Disruption of protein quality control of the human ether-à-go-go related gene K+ channel results in profound long QT syndrome. Heart Rhythm. 2022 02; 19(2):281-292. Ledford HA, Ren L, Thai PN, Park S, Timofeyev V, Sirish P, Xu W, Emigh AM, Priest JR, Perez MV, Ashley EA, Yarov-Yarovoy V, Yamoah EN, Zhang XD, Chiamvimonvat N. PMID: 34634443; PMCID: PMC8810706.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Model Systems for Addressing Mechanism of Arrhythmogenesis in Cardiac Repair. Curr Cardiol Rep. 2021 05 29; 23(6):72. Zhang XD, Thai PN, Lieu DK, Chiamvimonvat N. PMID: 34050853; PMCID: PMC8164614.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Prestin amplifies cardiac motor functions. Cell Rep. 2021 05 04; 35(5):109097. Zhang XD, Thai PN, Ren L, Perez Flores MC, Ledford HA, Park S, Lee JH, Sihn CR, Chang CW, Chen WC, Timofeyev V, Zuo J, Chan JW, Yamoah EN, Chiamvimonvat N. PMID: 33951436; PMCID: PMC8720583.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. Transgene Delivery to Human Induced Pluripotent Stem Cells Using Nanoparticles. Pharmaceuticals (Basel). 2021 Apr 06; 14(4). Yamoah MA, Thai PN, Zhang XD. PMID: 33917388; PMCID: PMC8067386.
      View in: PubMed   Mentions: 1  
    11. Cardiac small-conductance calcium-activated potassium channels in health and disease. Pflugers Arch. 2021 03; 473(3):477-489. Zhang XD, Thai PN, Lieu DK, Chiamvimonvat N. PMID: 33624131; PMCID: PMC7940285.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    12. Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation. J Gen Physiol. 2020 12 07; 152(12). Ledford HA, Park S, Muir D, Woltz RL, Ren L, Nguyen PT, Sirish P, Wang W, Sihn CR, George AL, Knollmann BC, Yamoah EN, Yarov-Yarovoy V, Zhang XD, Chiamvimonvat N. PMID: 33211795; PMCID: PMC7681919.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    13. NODAL inhibition promotes differentiation of pacemaker-like cardiomyocytes from human induced pluripotent stem cells. Stem Cell Res. 2020 12; 49:102043. Yechikov S, Kao HKJ, Chang CW, Pretto D, Zhang XD, Sun YH, Smithers R, Sirish P, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK. PMID: 33128951; PMCID: PMC7814970.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    14. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med. 2020 12; 9(12):1570-1584. Sirish P, Thai PN, Lee JH, Yang J, Zhang XD, Ren L, Li N, Timofeyev V, Lee KSS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young N, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. PMID: 32790136; PMCID: PMC7695637.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. Sci Adv. 2020 04; 6(15):eaba1104. Perez-Flores MC, Lee JH, Park S, Zhang XD, Sihn CR, Ledford HA, Wang W, Kim HJ, Timofeyev V, Yarov-Yarovoy V, Chiamvimonvat N, Rabbitt RD, Yamoah EN. PMID: 32285007; PMCID: PMC7141818.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss. Aging (Albany NY). 2019 12 08; 11(23):11541-11564. Lee JH, Kang M, Park S, Perez-Flores MC, Zhang XD, Wang W, Gratton MA, Chiamvimonvat N, Yamoah EN. PMID: 31812952; PMCID: PMC6932877.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    17. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018; 13:6073-6078. Yamoah MA, Moshref M, Sharma J, Chen WC, Ledford HA, Lee JH, Chavez KS, Wang W, López JE, Lieu DK, Sirish P, Zhang XD. PMID: 30323594; PMCID: PMC6179720.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    18. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018 03 16; 8(1):4670. Zhang XD, Coulibaly ZA, Chen WC, Ledford HA, Lee JH, Sirish P, Dai G, Jian Z, Chuang F, Brust-Mascher I, Yamoah EN, Chen-Izu Y, Izu LT, Chiamvimonvat N. PMID: 29549309; PMCID: PMC5856806.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). Sirish P, Ledford HA, Timofeyev V, Thai PN, Ren L, Kim HJ, Park S, Lee JH, Dai G, Moshref M, Sihn CR, Chen WC, Timofeyeva MV, Jian Z, Shimkunas R, Izu LT, Chiamvimonvat N, Chen-Izu Y, Yamoah EN, Zhang XD. PMID: 29025768; PMCID: PMC5662469.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017 03 13; 7(1):169. O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. PMID: 28279024; PMCID: PMC5427828.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A. J Physiol. 2017 04 01; 595(7):2271-2284. Zhang Z, Ledford HA, Park S, Wang W, Rafizadeh S, Kim HJ, Xu W, Lu L, Lau VC, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 27779751; PMCID: PMC5374114.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2016 May; 9(5). Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, Young JN, Yamoah EN, Haj F, Ripplinger CM, Hammock BD, Chiamvimonvat N. PMID: 27162031; PMCID: PMC4869994.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    23. 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization. J Mol Cell Cardiol. 2016 05; 94:180-188. Sun C, Simon SI, Foster GA, Radecke CE, Hwang HV, Zhang X, Hammock BD, Chiamvimonvat N, Knowlton AA. PMID: 27079253; PMCID: PMC4972711.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    24. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016 Jan 29; 291(5):2499-509. Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. PMID: 26515070; PMCID: PMC4732230.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):942-50. Myers R, Timofeyev V, Li N, Kim C, Ledford HA, Sirish P, Lau V, Zhang Y, Fayyaz K, Singapuri A, Lopez JE, Knowlton AA, Zhang XD, Chiamvimonvat N. PMID: 25995211; PMCID: PMC4545299.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    26. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015 Aug; 12(8):1845-51. Zhang XD, Lieu DK, Chiamvimonvat N. PMID: 25956967; PMCID: PMC4662728.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    27. Identification of a key residue in Kv7.1 potassium channel essential for sensing external potassium ions. J Gen Physiol. 2015 Mar; 145(3):201-12. Wang W, Flores MC, Sihn CR, Kim HJ, Zhang Y, Doyle KJ, Chiamvimonvat N, Zhang XD, Yamoah EN. PMID: 25712016; PMCID: PMC4338162.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2575-80. Zhang XD, Lee JH, Lv P, Chen WC, Kim HJ, Wei D, Wang W, Sihn CR, Doyle KJ, Rock JR, Chiamvimonvat N, Yamoah EN. PMID: 25675481; PMCID: PMC4345570.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015 Feb 20; 290(8):4663-4676. Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N. PMID: 25538241; PMCID: PMC4335206.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    30. Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons. J Neurosci. 2014 May 21; 34(21):7383-93. Lv P, Kim HJ, Lee JH, Sihn CR, Fathabad Gharaie S, Mousavi-Nik A, Wang W, Wang HG, Gratton MA, Doyle KJ, Zhang XD, Chiamvimonvat N, Yamoah EN. PMID: 24849370; PMCID: PMC4028507.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    31. Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes. Cardiovasc Res. 2014 Feb 01; 101(2):317-25. Zhang XD, Timofeyev V, Li N, Myers RE, Zhang DM, Singapuri A, Lau VC, Bond CT, Adelman J, Lieu DK, Chiamvimonvat N. PMID: 24282291; PMCID: PMC3896251.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    32. Slc26a6 functions as an electrogenic Cl-/HCO3- exchanger in cardiac myocytes. Cardiovasc Res. 2013 Dec 01; 100(3):383-91. Kim HJ, Myers R, Sihn CR, Rafizadeh S, Zhang XD. PMID: 23933580.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumps. PLoS One. 2013; 8(4):e61509. Tran V, Zhang X, Cao L, Li H, Lee B, So M, Sun Y, Chen W, Zhao M. PMID: 23585907; PMCID: PMC3621860.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    34. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One. 2013; 8(2):e55930. Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, Chen SC, Chen TY, Tang CY. PMID: 23424641; PMCID: PMC3570542.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    35. Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryot Cell. 2011 Sep; 10(9):1251-6. Gao RC, Zhang XD, Sun YH, Kamimura Y, Mogilner A, Devreotes PN, Zhao M. PMID: 21743003; PMCID: PMC3187056.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. Binding of ATP to the CBS domains in the C-terminal region of CLC-1. J Gen Physiol. 2011 Apr; 137(4):357-68. Tseng PY, Yu WP, Liu HY, Zhang XD, Zou X, Chen TY. PMID: 21444658; PMCID: PMC3068280.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    37. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain Res. 2010 Dec 02; 1363:159-69. Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL, Lyeth B, Gorin FA. PMID: 20869350; PMCID: PMC2996276.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    38. Chloride channels and transporters in human corneal epithelium. Exp Eye Res. 2010 Jun; 90(6):771-9. Cao L, Zhang XD, Liu X, Chen TY, Zhao M. PMID: 20346358; PMCID: PMC2873124.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    39. Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. Biophys J. 2010 Feb 03; 98(3):377-85. Zhang XD, Yu WP, Chen TY. PMID: 20141750; PMCID: PMC2814198.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. Amphiphilic blockers punch through a mutant CLC-0 pore. J Gen Physiol. 2009 Jan; 133(1):59-68. Zhang XD, Chen TY. PMID: 19088382; PMCID: PMC2606939.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    41. Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J Gen Physiol. 2009 Jan; 133(1):43-58. Zhang XD, Tseng PY, Yu WP, Chen TY. PMID: 19088381; PMCID: PMC2606940.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. ATP inhibition of CLC-1 is controlled by oxidation and reduction. J Gen Physiol. 2008 Oct; 132(4):421-8. Zhang XD, Tseng PY, Chen TY. PMID: 18824589; PMCID: PMC2553389.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    43. Large movement in the C terminus of CLC-0 chloride channel during slow gating. Nat Struct Mol Biol. 2006 Dec; 13(12):1115-9. Bykova EA, Zhang XD, Chen TY, Zheng J. PMID: 17115052.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    44. Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations. J Gen Physiol. 2006 Apr; 127(4):435-47. Zhang XD, Li Y, Yu WP, Chen TY. PMID: 16567465; PMCID: PMC2151512.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    45. Expression of novel isoforms of the CIC-1 chloride channel in astrocytic glial cells in vitro. Glia. 2004 Jul; 47(1):46-57. Zhang XD, Morishima S, Ando-Akatsuka Y, Takahashi N, Nabekura T, Inoue H, Shimizu T, Okada Y. PMID: 15139012.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells