Colleen E Clancy

Title(s)Professor, Physiology and Membrane Biology
SchoolSchool of Medicine
AddressTupper Hall 4206
CA 95616
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of the Predictive NeuroCardiovascular Simulator
    NIH OT2OD026580Aug 1, 2018 - Jul 31, 2022
    Role: Principal Investigator
    In silico Safety Pharmacology
    NIH R01HL128537Jul 5, 2016 - Dec 31, 2024
    Role: Principal Investigator
    A Systems Biology Approach to Study Cardiac Arrhythmias: iPS Cells and In Silico Modeling
    NIH/NHLBI R01HL128170Sep 15, 2015 - May 31, 2019
    Role: Co-Principal Investigator
    Predictive multiscale in silico cardio-pharmacology
    NIH/NHLBI U01HL126273Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Pharmacogenomics and antiarrhythmic therapy: An in silico investigation
    NIH/NHLBI R01HL085592Apr 15, 2007 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle. Elife. 2024 Feb 09; 12. Hernandez-Hernandez G, O'Dwyer SC, Yang PC, Matsumoto C, Tieu M, Fong Z, Lewis TJ, Santana LF, Clancy CE. PMID: 38335126; PMCID: PMC10942543.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Empowering Women in Electrophysiology: Insights on National Women's Heart Day. JACC Clin Electrophysiol. 2024 Feb; 10(2):189-192. Clancy CE, Parkash R, Shah M, Tedrow U. PMID: 38310490.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Harnessing AlphaFold to reveal state secrets: Prediction of hERG closed and inactivated states. bioRxiv. 2024 Jan 30. Ngo K, Yarov-Yarovoy V, Clancy CE, Vorobyov I. PMID: 38352360; PMCID: PMC10862728.
      View in: PubMed   Mentions:
    4. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle. bioRxiv. 2024 Jan 06. Hernandez-Hernandez G, O'Dwyer SC, Matsumoto C, Tieu M, Fong Z, Yang PC, Lewis TJ, Fernando Santana L, Clancy CE. PMID: 37425682; PMCID: PMC10327109.
      View in: PubMed   Mentions:
    5. Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel. J Gen Physiol. 2024 Feb 05; 156(2). Ngo K, Lopez Mateos D, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 38127314; PMCID: PMC10737443.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Toward Digital Twin Technology for Precision Pharmacology. JACC Clin Electrophysiol. 2024 Feb; 10(2):359-364. Yang PC, Jeng MT, Yarov-Yarovoy V, Santana LF, Vorobyov I, Clancy CE. PMID: 38069976.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Commun Biol. 2023 11 14; 6(1):1165. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Fernando Santana L. PMID: 37963972; PMCID: PMC10645748.
      View in: PubMed   Mentions: Translation:HumansCells
    8. Structural modeling of hERG channel-drug interactions using Rosetta. Front Pharmacol. 2023; 14:1244166. Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 38035013; PMCID: PMC10682396.
      View in: PubMed   Mentions: 1  
    9. Rate-dependent effects of state-specific sodium channel blockers in cardiac tissue: Insights from idealized models. J Theor Biol. 2023 09 21; 573:111595. Docken SS, Clancy CE, Lewis TJ. PMID: 37562674.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A multiscale predictive digital twin for neurocardiac modulation. J Physiol. 2023 09; 601(17):3789-3812. Yang PC, Rose A, DeMarco KR, Dawson JRD, Han Y, Jeng MT, Harvey RD, Santana LF, Ripplinger CM, Vorobyov I, Lewis TJ, Clancy CE. PMID: 37528537; PMCID: PMC10528740.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Res Sq. 2023 Jul 19. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Santana LF. PMID: 37502980; PMCID: PMC10371172.
      View in: PubMed   Mentions:
    12. The formation of K V 2.1 macro-clusters is required for sex-specific differences in L-type Ca V 1.2 clustering and function in arterial myocytes. bioRxiv. 2023 Jun 29. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Santana LF. PMID: 37425816; PMCID: PMC10327069.
      View in: PubMed   Mentions:
    13. Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel. bioRxiv. 2023 Jun 15. Ngo K, Mateos DL, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. PMID: 36909474; PMCID: PMC10002706.
      View in: PubMed   Mentions:
    14. Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein. Proc Natl Acad Sci U S A. 2023 03 07; 120(10):e2215916120. Han Y, Dawson JRD, DeMarco KR, Rouen KC, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Vorobyov I. PMID: 36853938; PMCID: PMC10013855.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    15. Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 2022; 13:966463. Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. PMID: 36188564; PMCID: PMC9523588.
      View in: PubMed   Mentions: 6  
    16. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Mol Pharmacol. 2022 Aug 30. Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. PMID: 36041862; PMCID: PMC9595204.
      View in: PubMed   Mentions: 2     Fields:    
    17. Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling. J Gen Physiol. 2022 09 05; 154(9). Guarina L, Moghbel AN, Pourhosseinzadeh MS, Cudmore RH, Sato D, Clancy CE, Santana LF. PMID: 35482009; PMCID: PMC9059386.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    18. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC Basic Transl Sci. 2022 Mar; 7(3):265-293. Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K. PMID: 35411324; PMCID: PMC8993767.
      View in: PubMed   Mentions: 10  
    19. Mechanisms of cAMP compartmentation in cardiac myocytes: experimental and computational approaches to understanding. J Physiol. 2021 10; 599(20):4527-4544. Harvey RD, Clancy CE. PMID: 34510451; PMCID: PMC8526402.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. Ivabradine for Postoperative JET: Clear for Take-Off? JACC Clin Electrophysiol. 2021 08; 7(8):1061-1063. Janson CM, Clancy CE. PMID: 34412869.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. A deep learning algorithm to translate and classify cardiac electrophysiology. Elife. 2021 07 02; 10. Aghasafari P, Yang PC, Kernik DC, Sakamoto K, Kanda Y, Kurokawa J, Vorobyov I, Clancy CE. PMID: 34212860; PMCID: PMC8282335.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    22. Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model. PLoS Comput Biol. 2021 06; 17(6):e1009145. Docken SS, Clancy CE, Lewis TJ. PMID: 34185778; PMCID: PMC8274935.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 09; 158:163-177. DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger JC, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. PMID: 34062207; PMCID: PMC8906354.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Mechanisms of flecainide induced negative inotropy: An in silico study. J Mol Cell Cardiol. 2021 09; 158:26-37. Yang PC, Giles WR, Belardinelli L, Clancy CE. PMID: 34004185; PMCID: PMC8772296.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 08; 110(2):380-391. Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. PMID: 33772748; PMCID: PMC8316283.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    26. Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment. J Theor Biol. 2021 06 21; 519:110619. Meyer EE, Clancy CE, Lewis TJ. PMID: 33740423; PMCID: PMC8650805.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants. PLoS Comput Biol. 2020 08; 16(8):e1008109. Kernik DC, Yang PC, Kurokawa J, Wu JC, Clancy CE. PMID: 32797034; PMCID: PMC7449496.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    28. Evolving Discovery of the Origin of the Heartbeat: A New Perspective on Sinus Rhythm. JACC Clin Electrophysiol. 2020 08; 6(8):932-934. Clancy CE, Santana LF. PMID: 32819527.
      View in: PubMed   Mentions: 12     Fields:    
    29. When Does the IC50 Accurately Assess the Blocking Potency of a Drug? J Chem Inf Model. 2020 03 23; 60(3):1779-1790. Gomis-Tena J, Brown BM, Cano J, Trenor B, Yang PC, Saiz J, Clancy CE, Romero L. PMID: 32105478; PMCID: PMC7357848.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. A Computational Pipeline to Predict Cardiotoxicity: From the Atom to the Rhythm. Circ Res. 2020 04 10; 126(8):947-964. Yang PC, DeMarco KR, Aghasafari P, Jeng MT, Dawson JRD, Bekker S, Noskov SY, Yarov-Yarovoy V, Vorobyov I, Clancy CE. PMID: 32091972; PMCID: PMC7155920.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    31. Selectivity filter modalities and rapid inactivation of the hERG1 channel. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):2795-2804. Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. PMID: 31980532; PMCID: PMC7022143.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    32. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 01; 107(1):102-111. Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. PMID: 31709525; PMCID: PMC6977398.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    33. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 09 02; 151(9):1116-1134. Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. PMID: 31371391; PMCID: PMC6719406.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    34. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 09; 597(17):4533-4564. Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. PMID: 31278749; PMCID: PMC6767694.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    35. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. PLoS Comput Biol. 2019 03; 15(3):e1006856. Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altintas I, Amaro RE, Clancy CE. PMID: 30849072; PMCID: PMC6426265.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2945-2954. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. PMID: 30728299; PMCID: PMC6386684.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    37. Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes. Front Pharmacol. 2018; 9:332. Agarwal SR, Gratwohl J, Cozad M, Yang PC, Clancy CE, Harvey RD. PMID: 29740315; PMCID: PMC5925456.
      View in: PubMed   Mentions: 19  
    38. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Front Physiol. 2018; 9:207. Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. PMID: 29706893; PMCID: PMC5907531.
      View in: PubMed   Mentions: 19  
    39. Sex, drugs, and funky rhythms. Heart Rhythm. 2018 04; 15(4):485-486. Vorobyov I, Clancy CE. PMID: 29605014.
      View in: PubMed   Mentions: 1     Fields:    
    40. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Front Pharmacol. 2018; 9:26. DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. PMID: 29449809; PMCID: PMC5799612.
      View in: PubMed   Mentions: 11  
    41. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep; 3(9):e00388. Sato D, Clancy CE, Bers DM. PMID: 28924617; PMCID: PMC5591396.
      View in: PubMed   Mentions: 8  
    42. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. J Physiol. 2017 07 15; 595(14):4695-4723. Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE. PMID: 28516454; PMCID: PMC5509858.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. PMID: 27808412; PMCID: PMC5374105.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    44. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. PMID: 27800622; PMCID: PMC5088243.
      View in: PubMed   Mentions: 1     Fields:    
    45. Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes. Pharmacol Ther. 2016 12; 168:23-28. Kurokawa J, Kodama M, Clancy CE, Furukawa T. PMID: 27595633; PMCID: PMC5140718.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    46. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. J Mol Cell Cardiol. 2016 Oct; 99:151-161. Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. PMID: 27545042; PMCID: PMC5453509.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. PLoS Comput Biol. 2016 07; 12(7):e1005005. Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy CE. PMID: 27409243; PMCID: PMC4943723.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    48. Cardiac Na Channels: Structure to Function. Curr Top Membr. 2016; 78:287-311. DeMarco KR, Clancy CE. PMID: 27586288; PMCID: PMC5398315.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    49. A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2016 08; 13(8):1652-60. Gray B, Bagnall RD, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang PC, Clancy CE, Sy RW, Semsarian C. PMID: 27157848; PMCID: PMC5453511.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    50. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Ann Biomed Eng. 2016 09; 44(9):2642-60. Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. PMID: 27138523; PMCID: PMC4983486.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    51. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. PLoS One. 2016; 11(3):e0150761. Moreno JD, Lewis TJ, Clancy CE. PMID: 26963710; PMCID: PMC4786197.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    52. Multiscale Modeling in the Clinic: Drug Design and Development. Ann Biomed Eng. 2016 09; 44(9):2591-610. Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. PMID: 26885640; PMCID: PMC4983472.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    53. Mechanisms Restricting Diffusion of Intracellular cAMP. Sci Rep. 2016 Jan 22; 6:19577. Agarwal SR, Clancy CE, Harvey RD. PMID: 26795432; PMCID: PMC4726171.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    54. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. PMID: 26515697; PMCID: PMC4784170.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    55. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016 Jan 29; 291(5):2499-509. Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. PMID: 26515070; PMCID: PMC4732230.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    56. Corrigendum to “In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome” [J. Mol. Cell. Cardiol. 2014 126–137]. Journal of Molecular and Cellular Cardiology. 2015 Oct 1; 87:270. Romero RL, Trenor TB, Yang YP, Saiz SJ, Clancy CC. .
      View in: Publisher Site   Mentions:
    57. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2015 Oct; 87:271-82. Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. PMID: 26859003; PMCID: PMC4935925.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    58. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophys J. 2015 Mar 24; 108(6):1414-1424. Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. PMID: 25809254; PMCID: PMC4375712.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    59. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. J Physiol. 2015 Mar 15; 593(6):1429-42. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. PMID: 25545172; PMCID: PMC4376422.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    60. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. PMID: 25772291; PMCID: PMC4376416.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    61. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. PMID: 25772290; PMCID: PMC4376415.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    62. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. PMID: 25772289; PMCID: PMC4376414.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    63. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discov Today Dis Models. 2014; 14:3-10. Yarov-Yarovoy V, Allen TW, Clancy CE. PMID: 26635886; PMCID: PMC4665638.
      View in: PubMed   Mentions: 7  
    64. Role of membrane microdomains in compartmentation of cAMP signaling. PLoS One. 2014; 9(4):e95835. Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. PMID: 24752595; PMCID: PMC3994114.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    65. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2014 Jul; 72:126-37. Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. PMID: 24631769; PMCID: PMC4066959.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    66. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. Clancy CE, Xiang YK. PMID: 24598634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Cardiac electrophysiological dynamics from the cellular level to the organ level. Biomed Eng Comput Biol. 2013; 5:69-75. Sato D, Clancy CE. PMID: 25288904; PMCID: PMC4147771.
      View in: PubMed   Mentions: 8  
    68. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. PMID: 23897695; PMCID: PMC3896218.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    69. Correction: Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons. PLoS ONE. 2013 May 28; 8(5). Lewin LN, Aksay AE, Clancy CC. .
      View in: Publisher Site   Mentions:
    70. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. J Cardiovasc Electrophysiol. 2013 Sep; 24(9):1021-7. Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. PMID: 23631727; PMCID: PMC4059362.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    71. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One. 2012; 7(10):e47250. Lewin N, Aksay E, Clancy CE. PMID: 23071770; PMCID: PMC3470566.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    72. In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Front Physiol. 2012; 3:360. Yang PC, Clancy CE. PMID: 23049511; PMCID: PMC3442371.
      View in: PubMed   Mentions: 25  
    73. Computational approaches to understand cardiac electrophysiology and arrhythmias. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H766-83. Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. PMID: 22886409; PMCID: PMC3774200.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    74. Sex and gender aspects in antiarrhythmic therapy. Handb Exp Pharmacol. 2012; (214):237-63. Kurokawa J, Kodama M, Furukawa T, Clancy CE. PMID: 23027454.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    75. Pathophysiology of the cardiac late Na current and its potential as a drug target. J Mol Cell Cardiol. 2012 Mar; 52(3):608-19. Moreno JD, Clancy CE. PMID: 22198344; PMCID: PMC3816394.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    76. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 2011 Aug 31; 3(98):98ra83. Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. PMID: 21885405; PMCID: PMC3328405.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimals
    77. Gender-based differences in cardiac diseases. J Biomed Res. 2011 Mar; 25(2):81-9. Yang PC, Clancy CE. PMID: 23554675; PMCID: PMC3596698.
      View in: PubMed   Mentions: 8  
    78. Non-Genomic Regulation of K+ and Ca2+ Channels by Sex Hormones. Journal of Arrhythmia. 2011 Jan 1; 27(Supplement):ss2_1. Furukawa FT, Kurokawa KJ, Asada AK, Bai BC, Nakamura NH, Isobe IM, Clancy CC. .
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    79. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput Biol. 2010 Dec 23; 6(12):e1001041. Oren RV, Clancy CE. PMID: 21203483; PMCID: PMC3009599.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    80. Effects of sex hormones on cardiac repolarization. J Cardiovasc Pharmacol. 2010 Aug; 56(2):123-9. Yang PC, Clancy CE. PMID: 20164789.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    81. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput Biol. 2010 Jan 29; 6(1):e1000658. Yang PC, Kurokawa J, Furukawa T, Clancy CE. PMID: 20126530; PMCID: PMC2813260.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    82. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. J Mol Cell Cardiol. 2010 Jan; 48(1):172-80. Protas L, Oren RV, Clancy CE, Robinson RB. PMID: 19665465; PMCID: PMC2813407.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    83. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovasc Res. 2009 Jun 01; 82(3):439-47. Ahrens-Nicklas RC, Clancy CE, Christini DJ. PMID: 19264765; PMCID: PMC2682617.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    84. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. J Physiol. 2009 Apr 01; 587(Pt 7):1513-25. Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. PMID: 19171659; PMCID: PMC2678222.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    85. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discov Today Dis Models. 2009; 6(3):71-84. Moreno JD, Clancy CE. PMID: 20652086; PMCID: PMC2905809.
      View in: PubMed   Mentions: 7  
    86. Arrhythmia models: in vivo, in vitro and in silico. Drug Discov Today Dis Models. 2009; 6(3):55-56. Akar FG, Clancy CE. PMID: 21072326; PMCID: PMC2976541.
      View in: PubMed   Mentions:
    87. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Curr Cardiol Rev. 2008 Nov; 4(4):244-50. Furukawa T, Kurokawa J, Clancy CE. PMID: 20066131; PMCID: PMC2801855.
      View in: PubMed   Mentions:    Fields:    
    88. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 2008 Sep 09; 118(11):1202-11. Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. PMID: 18779456; PMCID: PMC2908516.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    89. Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS One. 2008 Apr 30; 3(4):e2056. Xu J, Clancy CE. PMID: 18446231; PMCID: PMC2323611.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    90. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 2007 Dec 18; 116(25):2913-22. Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. PMID: 18056530.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    91. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13; 116(20):2325-45. Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. PMID: 17998470.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    92. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S47-50. Zhu ZI, Clancy CE. PMID: 17993328.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    93. L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3480-9. Zhu ZI, Clancy CE. PMID: 17933974.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    94. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52. Clancy CE, Wehrens XH. PMID: 17761312.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    95. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H66-75. Clancy CE, Zhu ZI, Rudy Y. PMID: 16997895; PMCID: PMC2034498.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    96. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet. 2006 Oct 01; 15(19):2888-902. Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. PMID: 16923798.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    97. Cardiac Na+ channels as therapeutic targets for antiarrhythmic agents. Handb Exp Pharmacol. 2006; (171):99-121. Glaaser IW, Clancy CE. PMID: 16610342.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    98. From mutation to clinical presentation: mechanisms in the black box. J Mol Cell Cardiol. 2005 Jun; 38(6):965-8. Zhu ZI, Clancy CE. PMID: 15878172.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    99. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res. 2005 Mar 18; 96(5):e25-34. Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. PMID: 15731462.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    100. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiol Rev. 2005 Jan; 85(1):33-47. Clancy CE, Kass RS. PMID: 15618477.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    101. Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovasc Res. 2005 Jan 01; 65(1):128-37. Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, Charpentier F. PMID: 15621040.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    102. Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J. 2004 Apr; 86(4):2606-14. Clancy CE, Kass RS. PMID: 15041696; PMCID: PMC1304107.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    103. Pharmacogenomics in the treatment of epilepsy. Pharmacogenomics. 2003 Nov; 4(6):747-51. Clancy CE, Kass RS. PMID: 14596638.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    104. Mechanisms of genetic arrhythmias: from DNA to ECG. Prog Cardiovasc Dis. 2003 Nov-Dec; 46(3):259-70. Glaaser IW, Kass RS, Clancy CE. PMID: 14685943.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    105. Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. J Biol Chem. 2003 Nov 21; 278(47):46718-26. Tateyama M, Rivolta I, Clancy CE, Kass RS. PMID: 14500710.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    106. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. PMID: 12695286.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    107. Mutations in cardiac sodium channels: clinical implications. Am J Pharmacogenomics. 2003; 3(3):173-9. Liu H, Clancy C, Cormier J, Kass R. PMID: 12814325.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    108. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest. 2002 Nov; 110(9):1251-62. Clancy CE, Tateyama M, Kass RS. PMID: 12417563; PMCID: PMC151612.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    109. Defective cardiac ion channels: from mutations to clinical syndromes. J Clin Invest. 2002 Oct; 110(8):1075-7. Clancy CE, Kass RS. PMID: 12393842; PMCID: PMC150807.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    110. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiol Genomics. 2002 Sep 03; 10(3):191-7. Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. PMID: 12209021.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    111. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002 Aug 23; 297(5585):1333-6. Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. PMID: 12193783.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    112. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. J Gen Physiol. 2002 Jul; 120(1):39-51. Liu H, Tateyama M, Clancy CE, Abriel H, Kass RS. PMID: 12084774; PMCID: PMC2311398.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    113. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 2002 Mar 12; 105(10):1208-13. Clancy CE, Rudy Y. PMID: 11889015; PMCID: PMC1997279.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    114. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. PMID: 12540747.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    115. Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med. 2001 Sep; 7(9):1021-7. Nuyens D, Stengl M, Dugarmaa S, Rossenbacker T, Compernolle V, Rudy Y, Smits JF, Flameng W, Clancy CE, Moons L, Vos MA, Dewerchin M, Benndorf K, Collen D, Carmeliet E, Carmeliet P. PMID: 11533705.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimals
    116. Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc Res. 2001 May; 50(2):301-13. Clancy CE, Rudy Y. PMID: 11334834.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    117. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 1999 Aug 05; 400(6744):566-9. Clancy CE, Rudy Y. PMID: 10448858.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    118. Identification of a protein kinase from Dictyostelium with homology to the novel catalytic domain of myosin heavy chain kinase A. J Biol Chem. 1997 May 02; 272(18):11812-5. Clancy CE, Mendoza MG, Naismith TV, Kolman MF, Egelhoff TT. PMID: 9115238.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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