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Colleen E Clancy

Title(s)Professor, Physiology and Membrane Biology
SchoolUniversity of California, Davis
Phone530-754-0254
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of the Predictive NeuroCardiovascular Simulator
    NIH OT2OD026580Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    In silico Safety Pharmacology
    NIH/NHLBI R01HL128537Jul 5, 2016 - Jun 30, 2020
    Role: Principal Investigator
    A Systems Biology Approach to Study Cardiac Arrhythmias: iPS Cells and In Silico Modeling
    NIH/NHLBI R01HL128170Sep 15, 2015 - May 31, 2019
    Role: Co-Principal Investigator
    Predictive multiscale in silico cardio-pharmacology
    NIH/NHLBI U01HL126273Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Pharmacogenomics and antiarrhythmic therapy: An in silico investigation
    NIH/NHLBI R01HL085592Apr 15, 2007 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. Selectivity filter modalities and rapid inactivation of the hERG1 channel. Proc Natl Acad Sci U S A. 2020 Jan 24. PMID: 31980532.
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    2. Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 Jan; 107(1):102-111. PMID: 31709525.
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    3. Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 Sep 02; 151(9):1116-1134. PMID: 31371391.
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    4. Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 Sep; 597(17):4533-4564. PMID: 31278749.
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    5. Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altintas I, Amaro RE, Clancy CE. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. PLoS Comput Biol. 2019 03; 15(3):e1006856. PMID: 30849072.
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    6. Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):2945-2954. PMID: 30728299.
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    7. Agarwal SR, Gratwohl J, Cozad M, Yang PC, Clancy CE, Harvey RD. Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes. Front Pharmacol. 2018; 9:332. PMID: 29740315.
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    8. Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Front Physiol. 2018; 9:207. PMID: 29706893.
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    9. Vorobyov I, Clancy CE. Sex, drugs, and funky rhythms. Heart Rhythm. 2018 04; 15(4):485-486. PMID: 29605014.
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    10. DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Front Pharmacol. 2018; 9:26. PMID: 29449809.
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    11. Sato D, Clancy CE, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep; 3(9):e00388. PMID: 28924617.
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    12. Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. J Physiol. 2017 07 15; 595(14):4695-4723. PMID: 28516454.
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    13. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. PMID: 27808412.
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    14. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. PMID: 27800622.
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    15. Kurokawa J, Kodama M, Clancy CE, Furukawa T. Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes. Pharmacol Ther. 2016 12; 168:23-28. PMID: 27595633.
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    16. Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. J Mol Cell Cardiol. 2016 Oct; 99:151-161. PMID: 27545042.
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    17. Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy CE. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. PLoS Comput Biol. 2016 07; 12(7):e1005005. PMID: 27409243.
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    18. DeMarco KR, Clancy CE. Cardiac Na Channels: Structure to Function. Curr Top Membr. 2016; 78:287-311. PMID: 27586288.
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    19. Gray B, Bagnall RD, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang PC, Clancy CE, Sy RW, Semsarian C. A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. 2016 08; 13(8):1652-60. PMID: 27157848.
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    20. Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Ann Biomed Eng. 2016 09; 44(9):2642-60. PMID: 27138523.
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    21. Moreno JD, Lewis TJ, Clancy CE. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. PLoS One. 2016; 11(3):e0150761. PMID: 26963710.
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    22. Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. Multiscale Modeling in the Clinic: Drug Design and Development. Ann Biomed Eng. 2016 09; 44(9):2591-610. PMID: 26885640.
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    23. Agarwal SR, Clancy CE, Harvey RD. Mechanisms Restricting Diffusion of Intracellular cAMP. Sci Rep. 2016 Jan 22; 6:19577. PMID: 26795432.
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    24. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697.
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    25. Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. J Biol Chem. 2016 Jan 29; 291(5):2499-509. PMID: 26515070.
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    26. Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2015 Oct; 87:271-82. PMID: 26859003.
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    27. Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophys J. 2015 Mar 24; 108(6):1414-1424. PMID: 25809254.
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    28. Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. J Physiol. 2015 Mar 15; 593(6):1429-42. PMID: 25545172.
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    29. Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, Sipido KR, Xie ZJ. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. J Physiol. 2015 Mar 15; 593(6):1361-82. PMID: 25772291.
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    30. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol. 2015 Mar 15; 593(6):1347-60. PMID: 25772290.
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    31. Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A. Deranged sodium to sudden death. J Physiol. 2015 Mar 15; 593(6):1331-45. PMID: 25772289.
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    32. Yarov-Yarovoy V, Allen TW, Clancy CE. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discov Today Dis Models. 2014; 14:3-10. PMID: 26635886.
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    33. Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling. PLoS One. 2014; 9(4):e95835. PMID: 24752595.
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    34. Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. J Mol Cell Cardiol. 2014 Jul; 72:126-37. PMID: 24631769.
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    35. Clancy CE, Xiang YK. Biological techniques: Wrapped around the heart. Nature. 2014 Mar 06; 507(7490):43-4. PMID: 24598634.
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    36. Sato D, Clancy CE. Cardiac electrophysiological dynamics from the cellular level to the organ level. Biomed Eng Comput Biol. 2013; 5:69-75. PMID: 25288904.
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    37. Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circ Res. 2013 Sep 13; 113(7):e50-e61. PMID: 23897695.
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    38. Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. J Cardiovasc Electrophysiol. 2013 Sep; 24(9):1021-7. PMID: 23631727.
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    39. Lewin N, Aksay E, Clancy CE. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PLoS One. 2012; 7(10):e47250. PMID: 23071770.
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    40. Yang PC, Clancy CE. In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Front Physiol. 2012; 3:360. PMID: 23049511.
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    41. Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. Computational approaches to understand cardiac electrophysiology and arrhythmias. Am J Physiol Heart Circ Physiol. 2012 Oct 01; 303(7):H766-83. PMID: 22886409.
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    42. Kurokawa J, Kodama M, Furukawa T, Clancy CE. Sex and gender aspects in antiarrhythmic therapy. Handb Exp Pharmacol. 2012; (214):237-63. PMID: 23027454.
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    43. Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. J Mol Cell Cardiol. 2012 Mar; 52(3):608-19. PMID: 22198344.
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    44. Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 2011 Aug 31; 3(98):98ra83. PMID: 21885405.
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    45. Yang PC, Clancy CE. Gender-based differences in cardiac diseases. J Biomed Res. 2011 Mar; 25(2):81-9. PMID: 23554675.
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    46. Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. PLoS Comput Biol. 2010 Dec 23; 6(12):e1001041. PMID: 21203483.
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    47. Yang PC, Clancy CE. Effects of sex hormones on cardiac repolarization. J Cardiovasc Pharmacol. 2010 Aug; 56(2):123-9. PMID: 20164789.
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    48. Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput Biol. 2010 Jan 29; 6(1):e1000658. PMID: 20126530.
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    49. Protas L, Oren RV, Clancy CE, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. J Mol Cell Cardiol. 2010 Jan; 48(1):172-80. PMID: 19665465.
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    50. Ahrens-Nicklas RC, Clancy CE, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovasc Res. 2009 Jun 01; 82(3):439-47. PMID: 19264765.
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    51. Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. J Physiol. 2009 Apr 01; 587(Pt 7):1513-25. PMID: 19171659.
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    52. Moreno JD, Clancy CE. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discov Today Dis Models. 2009; 6(3):71-84. PMID: 20652086.
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    53. Akar FG, Clancy CE. Arrhythmia models: in vivo, in vitro and in silico. Drug Discov Today Dis Models. 2009; 6(3):55-56. PMID: 21072326.
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    54. Furukawa T, Kurokawa J, Clancy CE. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Curr Cardiol Rev. 2008 Nov; 4(4):244-50. PMID: 20066131.
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    55. Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 2008 Sep 09; 118(11):1202-11. PMID: 18779456.
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    56. Xu J, Clancy CE. Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS One. 2008 Apr 30; 3(4):e2056. PMID: 18446231.
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    57. Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 2007 Dec 18; 116(25):2913-22. PMID: 18056530.
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    58. Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 2007 Nov 13; 116(20):2325-45. PMID: 17998470.
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    59. Zhu ZI, Clancy CE. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S47-50. PMID: 17993328.
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    60. Zhu ZI, Clancy CE. L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3480-9. PMID: 17933974.
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    61. Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52. PMID: 17761312.
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    62. Clancy CE, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H66-75. PMID: 16997895.
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    63. Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet. 2006 Oct 01; 15(19):2888-902. PMID: 16923798.
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    64. Glaaser IW, Clancy CE. Cardiac Na+ channels as therapeutic targets for antiarrhythmic agents. Handb Exp Pharmacol. 2006; (171):99-121. PMID: 16610342.
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    65. Zhu ZI, Clancy CE. From mutation to clinical presentation: mechanisms in the black box. J Mol Cell Cardiol. 2005 Jun; 38(6):965-8. PMID: 15878172.
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    66. Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circ Res. 2005 Mar 18; 96(5):e25-34. PMID: 15731462.
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    67. Clancy CE, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiol Rev. 2005 Jan; 85(1):33-47. PMID: 15618477.
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    68. Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, Charpentier F. Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovasc Res. 2005 Jan 01; 65(1):128-37. PMID: 15621040.
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    69. Clancy CE, Kass RS. Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J. 2004 Apr; 86(4):2606-14. PMID: 15041696.
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    70. Clancy CE, Kass RS. Pharmacogenomics in the treatment of epilepsy. Pharmacogenomics. 2003 Nov; 4(6):747-51. PMID: 14596638.
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    71. Glaaser IW, Kass RS, Clancy CE. Mechanisms of genetic arrhythmias: from DNA to ECG. Prog Cardiovasc Dis. 2003 Nov-Dec; 46(3):259-70. PMID: 14685943.
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    72. Tateyama M, Rivolta I, Clancy CE, Kass RS. Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. J Biol Chem. 2003 Nov 21; 278(47):46718-26. PMID: 14500710.
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    73. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. PMID: 12695286.
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    74. Liu H, Clancy C, Cormier J, Kass R. Mutations in cardiac sodium channels: clinical implications. Am J Pharmacogenomics. 2003; 3(3):173-9. PMID: 12814325.
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    75. Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest. 2002 Nov; 110(9):1251-62. PMID: 12417563.
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    76. Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. J Clin Invest. 2002 Oct; 110(8):1075-7. PMID: 12393842.
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    77. Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiol Genomics. 2002 Sep 03; 10(3):191-7. PMID: 12209021.
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    78. Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science. 2002 Aug 23; 297(5585):1333-6. PMID: 12193783.
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    79. Liu H, Tateyama M, Clancy CE, Abriel H, Kass RS. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. J Gen Physiol. 2002 Jul; 120(1):39-51. PMID: 12084774.
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    80. Clancy CE, Rudy Y. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 2002 Mar 12; 105(10):1208-13. PMID: 11889015.
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    81. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. PMID: 12540747.
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    82. Nuyens D, Stengl M, Dugarmaa S, Rossenbacker T, Compernolle V, Rudy Y, Smits JF, Flameng W, Clancy CE, Moons L, Vos MA, Dewerchin M, Benndorf K, Collen D, Carmeliet E, Carmeliet P. Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med. 2001 Sep; 7(9):1021-7. PMID: 11533705.
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    83. Clancy CE, Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc Res. 2001 May; 50(2):301-13. PMID: 11334834.
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    84. Clancy CE, Rudy Y. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 1999 Aug 05; 400(6744):566-9. PMID: 10448858.
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    85. Clancy CE, Mendoza MG, Naismith TV, Kolman MF, Egelhoff TT. Identification of a protein kinase from Dictyostelium with homology to the novel catalytic domain of myosin heavy chain kinase A. J Biol Chem. 1997 May 02; 272(18):11812-5. PMID: 9115238.
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