Daisuke Sato

Title(s)Associate Professor, Pharmacology
SchoolSchool of Medicine
AddressTupper Hall 2215
CA 95616
Phone530-752-4440
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    Collapse Research 
    Collapse Research Activities and Funding
    Modelling structural and functional heterogeneity in heart failure reveals arrhythmic impact
    NIH R01HL149349Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced Arrhythmias
    NIH R00HL111334Dec 1, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced Arrhythmias
    NIH K99HL111334Aug 21, 2012 - May 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Commun Biol. 2023 11 14; 6(1):1165. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Fernando Santana L. PMID: 37963972; PMCID: PMC10645748.
      View in: PubMed   Mentions: Translation:HumansCells
    2. The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Res Sq. 2023 Jul 19. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Santana LF. PMID: 37502980; PMCID: PMC10371172.
      View in: PubMed   Mentions:
    3. The formation of K V 2.1 macro-clusters is required for sex-specific differences in L-type Ca V 1.2 clustering and function in arterial myocytes. bioRxiv. 2023 Jun 29. Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Santana LF. PMID: 37425816; PMCID: PMC10327069.
      View in: PubMed   Mentions:
    4. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. J Physiol. 2023 Jul; 601(13):2655-2683. Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E. PMID: 36094888; PMCID: PMC10008525.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation. J Physiol. 2023 Jul; 601(13):2685-2710. Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. PMID: 36114707; PMCID: PMC10017376.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling. J Gen Physiol. 2022 09 05; 154(9). Guarina L, Moghbel AN, Pourhosseinzadeh MS, Cudmore RH, Sato D, Clancy CE, Santana LF. PMID: 35482009; PMCID: PMC9059386.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    7. Automated Object Detection in Experimental Data Using Combination of Unsupervised and Supervised Methods. Front Physiol. 2022; 13:805161. Wu Y, Wang Z, Ripplinger CM, Sato D. PMID: 35464087; PMCID: PMC9019745.
      View in: PubMed   Mentions: 1  
    8. Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives. Front Physiol. 2022; 13:836622. Colman MA, Alvarez-Lacalle E, Echebarria B, Sato D, Sutanto H, Heijman J. PMID: 35370783; PMCID: PMC8964409.
      View in: PubMed   Mentions: 6  
    9. Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves. J Physiol. 2021 07; 599(13):3267-3278. Sato D, Uchinoumi H, Bers DM. PMID: 33963531; PMCID: PMC8249358.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    10. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26; 22(11). Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. PMID: 34073281; PMCID: PMC8198068.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    11. Acute Low-Intensity Aerobic Exercise Modulates Intracortical Inhibitory and Excitatory Circuits in an Exercised and a Non-exercised Muscle in the Primary Motor Cortex. Front Physiol. 2019; 10:1361. Yamazaki Y, Sato D, Yamashiro K, Nakano S, Onishi H, Maruyama A. PMID: 31787901; PMCID: PMC6853900.
      View in: PubMed   Mentions: 12  
    12. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 09 02; 151(9):1116-1134. Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. PMID: 31371391; PMCID: PMC6719406.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    13. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 03 01; 8. Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. PMID: 30821687; PMCID: PMC6397001.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    14. Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves. Biophys J. 2019 02 05; 116(3):530-539. Xie Y, Yang Y, Galice S, Bers DM, Sato D. PMID: 30686487; PMCID: PMC6369574.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    15. Mathematical Analysis of the Role of Heterogeneous Distribution of Excitable and Non-excitable Cells on Early Afterdepolarizations. Frontiers in Physics. 2018 Oct 12; 6:117. Kim KS, Sato SD. .
      View in: Publisher Site   Mentions:
    16. Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release. J Am Heart Assoc. 2018 06 21; 7(13). Galice S, Xie Y, Yang Y, Sato D, Bers DM. PMID: 29929992; PMCID: PMC6064922.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    17. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 2018 01; 14(1):e1005906. Sato D, Dixon RE, Santana LF, Navedo MF. PMID: 29338006; PMCID: PMC5786340.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart. Circ Res. 2017 Dec 08; 121(12):1379-1391. Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM. PMID: 28970285; PMCID: PMC5722688.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep; 3(9):e00388. Sato D, Clancy CE, Bers DM. PMID: 28924617; PMCID: PMC5591396.
      View in: PubMed   Mentions: 8  
    20. Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying. Int J Mol Sci. 2017 Jun 16; 18(6). Sato D, Morino K, Nakagawa F, Murata K, Sekine O, Beppu F, Gotoh N, Ugi S, Maegawa H. PMID: 28621714; PMCID: PMC5486104.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    21. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes. J Gen Physiol. 2017 Jun 05; 149(6):639-659. Tajada S, Moreno CM, O'Dwyer S, Woods S, Sato D, Navedo MF, Santana LF. PMID: 28507079; PMCID: PMC5460949.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans. J Physiol. 2017 04 01; 595(7):2285-2297. Kennedy M, Bers DM, Chiamvimonvat N, Sato D. PMID: 27902841; PMCID: PMC5374119.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    23. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248. Shaw ND, Brand H, Kupchinsky ZA, Bengani H, Plummer L, Jones TI, Erdin S, Williamson KA, Rainger J, Stortchevoi A, Samocha K, Currall BB, Dunican DS, Collins RL, Willer JR, Lek A, Lek M, Nassan M, Pereira S, Kammin T, Lucente D, Silva A, Seabra CM, Chiang C, An Y, Ansari M, Rainger JK, Joss S, Smith JC, Lippincott MF, Singh SS, Patel N, Jing JW, Law JR, Ferraro N, Verloes A, Rauch A, Steindl K, Zweier M, Scheer I, Sato D, Okamoto N, Jacobsen C, Tryggestad J, Chernausek S, Schimmenti LA, Brasseur B, Cesaretti C, García-Ortiz JE, Buitrago TP, Silva OP, Hoffman JD, Mühlbauer W, Ruprecht KW, Loeys BL, Shino M, Kaindl AM, Cho CH, Morton CC, Meehan RR, van Heyningen V, Liao EC, Balasubramanian R, Hall JE, Seminara SB, Macarthur D, Moore SA, Yoshiura KI, Gusella JF, Marsh JA, Graham JM, Lin AE, Katsanis N, Jones PL, Crowley WF, Davis EE, FitzPatrick DR, Talkowski ME. PMID: 28067909; PMCID: PMC5473428.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    24. Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction. Biophys J. 2016 Jun 21; 110(12):2671-2677. Galice S, Bers DM, Sato D. PMID: 27332125; PMCID: PMC4919541.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophys J. 2016 Jan 19; 110(2):382-390. Sato D, Shannon TR, Bers DM. PMID: 26789761; PMCID: PMC4724649.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue. Biophys J. 2014 Sep 16; 107(6):1313-7. Sato D, Bartos DC, Ginsburg KS, Bers DM. PMID: 25229139; PMCID: PMC4167289.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Arrhythmogenic transient dynamics in cardiac myocytes. Biophys J. 2014 Mar 18; 106(6):1391-7. Xie Y, Izu LT, Bers DM, Sato D. PMID: 24655514; PMCID: PMC3984988.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation? Europace. 2014 Mar; 16(3):452-7. Xie Y, Grandi E, Bers DM, Sato D. PMID: 24569900; PMCID: PMC3934848.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Formation of spatially discordant alternans due to fluctuations and diffusion of calcium. PLoS One. 2013; 8(12):e85365. Sato D, Bers DM, Shiferaw Y. PMID: 24392005; PMCID: PMC3877395.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    30. Cardiac electrophysiological dynamics from the cellular level to the organ level. Biomed Eng Comput Biol. 2013; 5:69-75. Sato D, Clancy CE. PMID: 25288904; PMCID: PMC4147771.
      View in: PubMed   Mentions: 8  
    31. β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets. J Mol Cell Cardiol. 2013 May; 58:153-61. Xie Y, Grandi E, Puglisi JL, Sato D, Bers DM. PMID: 23481579; PMCID: PMC3628092.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    32. Ca²⁺ waves in the heart. J Mol Cell Cardiol. 2013 May; 58:118-24. Izu LT, Xie Y, Sato D, Bányász T, Chen-Izu Y. PMID: 23220129; PMCID: PMC3660086.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes? Biophys J. 2012 Apr 18; 102(8):L31-3. Sato D, Despa S, Bers DM. PMID: 22768959; PMCID: PMC3328690.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    34. How does stochastic ryanodine receptor-mediated Ca leak fail to initiate a Ca spark? Biophys J. 2011 Nov 16; 101(10):2370-9. Sato D, Bers DM. PMID: 22098735; PMCID: PMC3218344.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    35. Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias. Heart Rhythm. 2012 Jan; 9(1):115-22. Chang MG, Sato D, de Lange E, Lee JH, Karagueuzian HS, Garfinkel A, Weiss JN, Qu Z. PMID: 21855520; PMCID: PMC3246094.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    36. So little source, so much sink: requirements for afterdepolarizations to propagate in tissue. Biophys J. 2010 Sep 08; 99(5):1408-15. Xie Y, Sato D, Garfinkel A, Qu Z, Weiss JN. PMID: 20816052; PMCID: PMC2931729.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    37. Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos? Biophys J. 2010 Aug 04; 99(3):765-73. Sato D, Xie LH, Nguyen TP, Weiss JN, Qu Z. PMID: 20682253; PMCID: PMC2913181.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    38. Acceleration of cardiac tissue simulation with graphic processing units. Med Biol Eng Comput. 2009 Sep; 47(9):1011-5. Sato D, Xie Y, Weiss JN, Qu Z, Garfinkel A, Sanderson AR. PMID: 19655187; PMCID: PMC2734265.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    39. Bifurcation and chaos in a model of cardiac early afterdepolarizations. Phys Rev Lett. 2009 Jun 26; 102(25):258103. Tran DX, Sato D, Yochelis A, Weiss JN, Garfinkel A, Qu Z. PMID: 19659123; PMCID: PMC2726623.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    40. Glycosylation of fluorophenols by plant cell cultures. Int J Mol Sci. 2009 Apr 27; 10(5):1942-1949. Shimoda K, Kubota N, Kondo Y, Sato D, Hamada H. PMID: 19564930; PMCID: PMC2695258.
      View in: PubMed   Mentions: 2     Fields:    Translation:CellsPHPublic Health
    41. Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):2983-8. Sato D, Xie LH, Sovari AA, Tran DX, Morita N, Xie F, Karagueuzian H, Garfinkel A, Weiss JN, Qu Z. PMID: 19218447; PMCID: PMC2651322.
      View in: PubMed   Mentions: 129     Fields:    Translation:Animals
    42. Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation. Circ J. 2008 Aug; 72(8):1351-8. Tatsumi K, Otani H, Sato D, Enoki C, Iwasaka T, Imamura H, Taniuchi S, Kaneko K, Adachi Y, Ikehara S. PMID: 18654025.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    43. Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak. Biophys J. 2008 Sep 15; 95(6):3100-10. Xie LH, Sato D, Garfinkel A, Qu Z, Weiss JN. PMID: 18539635; PMCID: PMC2527258.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    44. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008 Jan 15; 94(2):411-23. Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. PMID: 18160661; PMCID: PMC2157257.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    45. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J. 2008 Jan 15; 94(2):392-410. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. PMID: 18160660; PMCID: PMC2157228.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    46. Dispersion of refractoriness and induction of reentry due to chaos synchronization in a model of cardiac tissue. Phys Rev Lett. 2007 Sep 14; 99(11):118101. Xie Y, Hu G, Sato D, Weiss JN, Garfinkel A, Qu Z. PMID: 17930473.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. Inferring the cellular origin of voltage and calcium alternans from the spatial scales of phase reversal during discordant alternans. Biophys J. 2007 Feb 15; 92(4):L33-5. Sato D, Shiferaw Y, Qu Z, Garfinkel A, Weiss JN, Karma A. PMID: 17172300; PMCID: PMC1783870.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    48. Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J. 2007 Jan 15; 92(2):448-60. Hayashi H, Shiferaw Y, Sato D, Nihei M, Lin SF, Chen PS, Garfinkel A, Weiss JN, Qu Z. PMID: 17071663; PMCID: PMC1751420.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    49. Spatially discordant alternans in cardiac tissue: role of calcium cycling. Circ Res. 2006 Sep 01; 99(5):520-7. Sato D, Shiferaw Y, Garfinkel A, Weiss JN, Qu Z, Karma A. PMID: 16902177.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    50. Clinical significance of the electrophysiologic study (EPS)-guided therapy for the secondary prevention of ventricular tachycardia. Circ J. 2006 Mar; 70(3):268-72. Yuge M, Niwano S, Moriguchi M, Sasaki T, Hirasawa S, Imaki R, Sato D, Izumi T. PMID: 16501291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    51. Coupled dynamics of voltage and calcium in paced cardiac cells. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Feb; 71(2 Pt 1):021903. Shiferaw Y, Sato D, Karma A. PMID: 15783348; PMCID: PMC4278950.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
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